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On Tuesday's Mark Levin Show, we lost an American legend: Dolly Parton passed away at the age of 80. The news was sudden and hits in a personal way. Dolly was the quintessential American: grew up dirt poor, she became a success not due to socialism or government programs, but through talent and hard work. She wasn't a political hack and had her opinions, but she loved this country and was a great patriot. There was never any hint of scandal in her private life. She had some health problems in the last years of her life and recently posted basically a goodbye to her fans. She'll be remembered along with legends like Elvis and Johnny Cash. Dolly Parton, American legend. She will be missed. Also, Social Security is in deep trouble. Founded in 1935 as government-funded retirement insurance, it's expanded massively from its original scope to more than 58 million recipients. Unlike in years past, soon there will not be enough workers to pay into the system. It's effectively broke. Social Security is meant to be funded by payroll taxes - effectively, a tax on employment. The money is supposed to be deposited into a trust fund, but that no longer exists. Today's retirees get less benefits than they paid in. And those who didn't pay into the system, like illegal aliens, get full benefits. Politicians are running Social Security into the ground like they did Medicare. Then, why are so many young people socialists? Because they don't read substantive stuff. And not these AI-generated books, but real books by real authors who did their own original research. Young people these days would rather get on TikTok and social media than read a book about America, the Constitution, the Third Reich, the Holocaust, or isolationism in the 1930s that led to Pearl Harbor. Ever see these videos where someone goes to college campuses and ask students basic questions about American civics? What does the Senate do? What is the Electoral College? What does packing the Supreme Court mean? They haven't a clue. This is why education is so important, especially early in life. We've handed education over to the government and teachers' unions, and we wonder why kids grow up loving socialism? Finally, Jeanne Allen, author of "The Education Avengers: How and Why a New Class of Heroes Is Fighting America's Biggest Battle," tells the stories of twelve remarkable individuals who, like The Avengers from the Marvel movie, fought for those who can't defend themselves: children. The Education Avengers took on the Hydra - aka the education establishment, the many-headed tangle of rules, compliance mandates, unions and apathy. These people come from different backgrounds: teachers, entrepreneurs, pastors, parents, innovators and business leaders. They're examples of what ordinary people can do when they band together and don't accept the status quo. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Why treating the cell, not the protein, could turn chronic disease treatment into something closer to a cure. You've built single-cell pipelines that spit out clusters, p-values and target lists, but nothing that survives contact with the clinic. What if the clustering method itself is quietly leading you astray? Adam Freund is Founder and CEO of Arda Therapeutics, a biotech using single-cell sequencing to find the pathogenic cells driving chronic disease. He spent seven years as a Principal Investigator at Calico Life Sciences, building a research lab on the biology of ageing and helping grow the company from 15 to more than 200 people, and holds a PhD in Molecular and Cell Biology from UC Berkeley. You'll get a working model for how Arda's discovery engine turns single-cell and spatial transcriptomic data into causal cell targets. Adam explains why a common statistical shortcut in single-cell analysis produces disease signals that don't hold up and how cell depletion could replace daily dosing with a handful of treatments that reset the immune system. Ross and Adam cover how Arda finds pathogenic cell populations across hundreds of donors, why chi-squared tests on cell clusters can substitute cell count for donor count without anyone noticing, and how B-cell depletion therapies proved that removing a cell can beat blocking its pathway. This one is for data science leaders and computational biologists building single-cell pipelines, not listeners after a general intro to drug discovery. Key Takeaways - Chi-squared tests on cell clusters draw their statistical power from the number of cells, not the number of donors, so a single oversampled patient can produce the same p-value as a hundred-donor study. - Rituximab clears 100% of B cells from circulation yet does nothing for lupus because the disease-driving cells live in tissue, not blood, a lesson now shaping where Arda tests its own molecules. - Neighborhood analysis scores each cell by the donor identity of its nearest neighbours rather than forcing cells into predefined clusters, producing a continuous disease-enrichment map with no cluster boundaries. - When depleted cells regrow, they often come back without the trait that made them harmful in the first place, which means a handful of doses can hold a chronic disease in remission for months. Chapter Markers 00:00 Why cell depletion beats pathway blocking 01:05 Welcome Adam Freund to the show 01:30 From Calico Life Sciences to founding Arda 03:29 Why blocking one pathway rarely works 05:32 B-cell depletion as the proof of concept 08:14 Building a modular library of depletion tools 10:46 Single-cell sequencing removes the need for a hypothesis 11:43 Why clustering is a dial, not ground truth 15:24 The chi-squared trap in single-cell analysis 20:40 Neighbourhood analysis and donor-weighted scoring 23:44 Moving from enrichment to causality 26:32 Inside Arda's lead fibrosis program 30:33 Why solid tissue testing beats blood samples 34:25 Simulating depletion in spatial transcriptomic data 38:49 The case for intermittent dosing over daily pills 43:58 The data infrastructure behind Arda's platform 48:46 Where spatial and protein data are heading Useful Links & Resources - Adam Freund on LinkedIn: https://www.linkedin.com/in/adam-freund-0657654 - CorrDyn: https://corrdyn.com Connect With the Show - Host Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/ - Host Ross Katz on X: https://x.com/brosskatz - CorrDyn on LinkedIn: https://www.linkedin.com/company/corrdyn/ If your team runs single-cell pipelines, how do you currently decide on the number of clusters, and have you ever checked whether your significance scales with donor count rather than cell count? Tell us in the comments; we're building a running list of data QA checks for biotech data science teams. Visit corrdyn.com to learn how CorrDyn can help your organization extract value from data.
Most mainstream media outlets have spent the last several years convincing Americans that a recession is either here or just around the corner. But according to tech analyst Ray Wang and category design pioneer Christopher Lochhead, the real story about the US economy looks very different from what we are being fed. In a recent episode of Disrupt TV, the two thought leaders broke down the actual data behind American economic growth, the rise of AI-driven entrepreneurship, and a new investment program that could reshape generational wealth in this country. You're listening to Christopher Lochhead: Follow Your Different. We are the real dialogue podcast for people with a different mind. So get your mind in a different place, and hey ho, let's go. Record Business Starts Signal a Thriving US Economy Despite relentless recession predictions from commentators and media personalities, Americans are starting new companies at a record pace. More than 5.6 million business applications were filed in 2025 alone, with over 400,000 new companies being created every single month. This level of entrepreneurial activity has not been seen in the modern era. Layoffs are also at historic lows, GDP is still growing, and inflation has come down from 4.2% in May to 3.5%. Initial unemployment claims have recently fallen to their lowest level since 1969. Meanwhile, prediction markets like Kalshi and Polymarket have dropped recession odds from around 28 to 30% in April to just 4 to 11% today, showing that people putting real money on the line do not believe a recession is coming. AI Is Creating a New Class of Entrepreneur The rise of artificial intelligence is fundamentally changing who can build and run a successful business. Small teams of two to three people are now executing at a level that previously required thirty or more employees. This shift from knowledge worker to what Lochhead calls a “creator capitalist” is fueling much of the new company growth happening across the US economy. Ray Wang noted that we are beginning to see ten-person companies generating hundreds of millions in revenue, and the trend is only accelerating. As an example, the former CEO of Kirkland and Ellis, the largest law firm in the United States, left to launch an AI-first law firm called Irving with just twenty people. This signals a profound restructuring of professional services and virtually every other industry, driven entirely by AI innovation. Trump Accounts Could Close the Wealth Gap One of the most underreported developments in the US economy is the launch of the Invest America program, commonly referred to as Trump accounts. Every child born in America can now receive a $1,000 federal contribution into a protected investment account that grows through an index fund until the child turns eighteen. Family members and friends can contribute up to $5,000 per year into these accounts and receive a tax break for doing so. The math behind compounding returns is striking. A child who receives $5,000 per year from birth to age eighteen, invested in the S&P 500, could have approximately $250,000 by their eighteenth birthday. Michael and Susan Dell have already pledged $6.25 billion to give $250 to twenty-five million American children aged ten and under, making it the largest charitable investment gift in American history. Lochhead believes this new model of charitable investing, giving gifts that compound over time rather than providing temporary relief, represents a powerful and lasting solution to economic inequality. To hear more from Ray Wang and Christopher’s discussions, download and listen to this episode. Bio R “Ray” Wang (pronounced WAHNG) is the Founder, Chairman, and Principal Analyst of Silicon Valley based Constellation Research Inc. He co-hosts DisrupTV, a weekly enterprise tech and leadership webcast that averages 50,000 views per episode and authors a business strategy and technology blog that has received millions of page views per month. Wang also serves as a non-resident Senior Fellow at The Atlantic Council's GeoTech Center. Since 2003, Ray has delivered thousands of live and virtual keynotes around the world that are inspiring and legendary. Wang has spoken at almost every major tech conference. His ground-breaking bestselling book on digital transformation, Disrupting Digital Business, was published by Harvard Business Review Press in 2015. Ray's new book about Digital Giants and the future of business titled, Everybody Wants to Rule the World will be released July 2021 by Harper Collins Leadership. Ray Wang is well quoted and frequently interviewed in media outlets such as the Wall Street Journal, Fox Business News, CNBC, Yahoo Finance, Cheddar, CGTN America, Bloomberg, Tech Crunch, ZDNet, Forbes, and Fortune. He is one of the top technology analysts in the world. Links Follow Ray Wang! Website | Twitter | LinkedIn | Constellation Research | DisrupTV We hope you enjoyed this episode of Christopher Lochhead: Follow Your Different™! Christopher loves hearing from his listeners. Feel free to email him, connect on Facebook, X (formerly Twitter), Instagram, and subscribe on Apple Podcast / Spotify!
Clarence Ford spoke to Inzalo co-founder Diego Avila about the new agave brand & its recognition of 4 international awards. Views and News with Clarence Ford is the mid-morning show on CapeTalk. This 3-hour long programme shares and reflects a broad array of perspectives. It is inspirational, passionate and positive. Host Clarence Ford’s gentle curiosity and dapper demeanour leave listeners feeling motivated and empowered. Known for his love of jazz and golf, Clarrie covers a range of themes including relationships, heritage and philosophy. Popular segments include Barbs’ Wire at 9:30am (Mon-Thurs) and The Naked Scientist at 9:30 on Fridays. Thank you for listening to a podcast from Views & News with Clarence Ford Listen live on Primedia+ weekdays between 09:00 and 12:00 (SA Time) to Views and News with Clarence Ford broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/erjiQj2 or find all the catch-up podcasts here https://buff.ly/BdpaXRn Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567See omnystudio.com/listener for privacy information.
SYNGAP1-related disorder negatively impacts synaptic signalling during critical periods of brain development, leading to a range of cognitive, epileptic, behavioural, and motor symptoms. In a new episode of the pharmaphorum podcast, web editor Nicole Raleigh spoke with Kelly Gold, CFO of CAMP4 Therapeutics, about antisense oligonucleotides (or ASOs) - medicines designed to selectively restore natural protein production in diseases caused by gene under expression. Gold discusses the space and CAMP4's CMP-002 study, targeting the regRNA associated SYNGAP1 gene. You can listen to episode 269 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
From celebrity wedding details to the timing of military strikes, prediction markets have opened the door to gambling on almost anything. They’ve also created a new class of insider trader that platforms and US regulators are racing to stop. On today’s Big Take podcast, Bloomberg’s Denitsa Tsekova and Leonardo Nicoletti join host Sarah Holder to break down a $200 million surge in unusual bets on Polymarket — and explore what it will take for regulators to rein them in. Read more: Prediction Markets Are Minting a New Type of Insider Trader We have a special Bloomberg subscription offer for podcast listeners at Bloomberg.com/podcastoffer. Hosted by Sarah Holder; Produced by Rachael Lewis-Krisky and Victor Swezey; Reported by Denitsa Tsekova and Leonardo Nicoletti; Edited by Aaron Edwards and Julia Weaver. Fact-checking by Victor Swezey, Laura Newcombe and David Fox; Engineering by Emma Munger. Senior Producer: Naomi Shavin; Deputy Executive Producer: Julia Weaver. Executive Producer: Nicole Beemsterboer.See omnystudio.com/listener for privacy information.
New Class of Pittsburgh Walk of Fame, Joe Bartnick, Raiding the Aglorithm, Big Cat, Guy Junker, and more.
New Class of Pittsburgh Walk of Fame, Joe Bartnick, Raiding the Aglorithm, Big Cat, Guy Junker, and more.See omnystudio.com/listener for privacy information.
July 10, 2026: Axios warns about AI's new class divide: the haves, the have-nots, and the "no-nots" who are already being shaped by AI without realizing it. Then I get into new Indeed and Business Insider data showing that AI is moving into job titles far beyond tech, from physical therapy to legal, finance, marketing, and management. The bigger issue is not just who has access to AI. It's who knows how to use it, who is being quietly managed by it, and whether leaders use AI to make people better or slowly de-skill them.
Peacewarts returns tomorrow with a brand-new department, but first, a brief pause. In this informal update, Avis Kalfsbeek shares what she's been working on over the past month—from launching Bullet Poof and caring for her mother to working on the latest Pedro novella and developing a new long-term project called The Peace Experiments. She also offers heartfelt thanks to everyone who joined her for the 30 days of Kitty O'Compost during National Gun Violence Awareness Month. The episode introduces a new idea that will weave through the remainder of the Peacewarts curriculum: the commons. Throughout the upcoming classes, listeners will explore peace not simply as the absence of violence, but as something built together through the care of shared resources, relationships, and community spaces. Whether you're returning to Peacewarts or discovering it for the first time, this episode serves as a welcoming bridge to the next department, Resonant Charms 101, beginning in the next episode. Join the Community / Get the Books:AvisKalfsbeek.com Podcast Music:Javier Peke Rodriguez “I am late, madame Curie” Bandcamp: https://javierpekerodriguez.bandcamp.com/ Spotify: https://open.spotify.com/artist/3QuyqfXEKzrpUl6b12I3KW
There's a new cohort of journalists learning how to make radio in California prisons. Today, we introduce you to this year's Uncuffed class at the California Institution for Women - through their favorite songs.
Whether it's his BMW 2000 CS, his BMW 1800 Ti or his Son of Cobra BMW 2002 Tii, David Smothers refreshes his New Class models by integrating modern technology. He also fuels his SoCal Vintage BMW community with pies from his own Julian Pie Company.Discover more and follow us:David Smothers' pies on Instagram @julianpiecompanyBMW Classic on Instagram @bmwclassicMini Classic on Instagram @official_miniclassicJP on Instagram @jprathgenClassic Driver on Instagram @classicdriver Become a guest on the Classic Heart podcast: You have an exciting story about classic BMW to tell? Send us an email bmwgroup-classic@shot-one.de
Take the Daybreak listener survey here.Meet Ranjan. He works at Deloitte by day and spends his evenings strapping a camera to his forehead, recording himself doing household chores by evening. He's a physical AI trainer, a part of a growing gig economy built around creating training data to teach humanoid robots human behaviour.Reporter Sakshi Sadashiv joins host Rachel Varghese to break down how this supply chain works: from gig workers in Delhi, to the firms like Tesla and Nvidia that eventually buy their footage from the companies that vet, annotate and package it for sale. And why this feels like a pattern India has been in before.*Read Sakshi's original story here.
We've got RAF 10 this weekend, a New '28 Big Board, and Final X next weekend - let's dive into it!TIMESTAMPS:0:00 - It's RAF Week!06:55 - Class of 2028 Big Board13:20 - New ‘28 Top 1024:05 - Stock Up28:10 - Final X31:00 - Spencer Lee vs Luke Lilledahl39:30 - Jax Forrest vs Marcus Blaze46:25 - Bo Bassett vs Real Woods58:10 - Zain Retherford vs Ridge Lovett01:02:00 - David Carr vs James Green01:04:30 - Levi Haines vs Chance Marsteller01:10:15 - Zahid Valencia vs Kyle Dake01:20:40 - Kyle Snyder vs Stephen Buchanan01:26:30 - Mason Parris vs Wyatt Hendrickson01:31:00 - Kennedy Blades Going Full Time RAF/WFSRokfin.com/MatScouts for all of Willie's Content!Be sure to SUBSCRIBE to the podcast. NEW EPISODES WEEKLY! Support the show & leave a 5-star rating and review on Apple Podcasts, and shop some apparel on BASCHAMANIA.com! For all partnership and sponsorship inquiries, email info@baschamania.com.BASCHAMANIA is a Basch Solutions Production. Learn more about Basch Solutions, a digital marketing agency specializing in custom websites, content creation, and digital strategy, at BaschSolutions.com.
The MatScouts Class of 2027 Senior Big Board is OUT, and on today's show, we take a look at the big board & its data!TIMESTAMPS:0:00 - Start of Show01:55 - U23 World Team Criteria17:35 - Ben Askren Competing at RAF25:05 - RAF Georgia27:55 - New Class of 2027 Big Board31:30 - The Top Ten46:30 - The 5 Biggest Stock Up55:50 - Content Coming Up57:00 - Instagram Talk & Show Goes Off The Rails01:06:55 - RAF & Busy Summer01:13:10 - Macch/Hidlay in VARokfin.com/MatScouts for all of Willie's Content!Be sure to SUBSCRIBE to the podcast. NEW EPISODES WEEKLY! Support the show & leave a 5-star rating and review on Apple Podcasts, and shop some apparel on BASCHAMANIA.com! For all partnership and sponsorship inquiries, email info@baschamania.com.BASCHAMANIA is a Basch Solutions Production. Learn more about Basch Solutions, a digital marketing agency specializing in custom websites, content creation, and digital strategy, at BaschSolutions.com.
0:00: Rex made his first visit to PGA Frisco, site of next year's PGA Championship. What'd he think? 09:30: The winners and losers of the new-look Florida swing 19:00: The Tier 1/Tier 2 split for 2028 is the talk of the Tour at Colonial 30:00: What else to watch for this week in Fort Worth Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
On April 23, the Wilson County Extension Master Gardeners (WCEMGs) had the wonderful opportunity of having Dr. Calvin Finch present on monarch butterflies and milkweed. Free milkweed plants and seeds were provided to everyone in attendance! The next monthly meeting and presentation will be on Thursday, May 28, from 6-7:30 p.m. at the Wilson County Justice Center Annex, 800 10th St. in Floresville. There will be a special presentation by the Urban Ag Renaissance. This presentation will provide education on urban farming and self-sustaining ecosystems. The WCEMG monthly meetings and presentations are free and open to the public! The WCEMGs... Article Link
Shawn, Sam, and Jacob give their thoughts on trading up for Mansoor Delane, give their thoughts on the Chiefs' selections, and ask what they can expect from each player selected in the NFL draft.
ACT-IAC has relaunched its Partners Program with a 2026 class built for a moment when government and industry are looking for steadier leadership. The new cohort brings together senior leaders who want to deepen their impact and learn from a Pathfinder team drawn from across agencies and major contractors. We get the big-picture view of this new chapter from ACT-IAC President and CEO, Dave Wennergren.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
We've got some important changes coming to our safety points system, and we believe these adjustments are going to provide much more clarity to our driving force while continuing our commitment to safety accountability. Listen in as Jason Bolton of our safety leadership talks with David Broyles about the particulars and what you can expect beginning April 1.
Spencer Klavan joins Bridget for a fascinating conversation about why Plato's 2,000-year-old warning about the invention of writing perfectly explains our AI panic, what it's like to invent an entire language for Daily Wire's Pendragon Cycle (and how it made him finally understand Tolkien), and why AI can only reproduce the "outer word" while humans alone possess the "inner word." They discuss how Instagram reels have replaced sitcoms as the shared cultural touchstone for exhausted parents, why students can't finish movies anymore and what that means for the future, the death of observational comedy after Hannah Gadsby turned standup into trauma porn, and why the real class divide is between people who can sustain attention and people who can't. They also cover how liberal arts education might be the most economically valuable thing you can do in the age of AI, the embodiment problem (why Bridget asked humans about cancer instead of ChatGPT), the fatal mistake of thinking truth is whatever the opposite of politeness is, the soul in a truly great work of art, and what happens when you realize learning comes with pain but knowing comes with joy.Check out Spencer's Substack - https://rejoiceevermore.substack.com/
Today's episode has a little bit of everything. You'll hear about some sportspeople taking on the best in the world at the Paralympic Winter Games, then meet a sporty, speedy teen travelling the world to follow her dream.After that, we'll get a little bit sticky learning something new about sweet, runny honey before grabbing a turtle and a toothbrush for the Wow of the Week!Quiz Questions1.Aussie flag bearer and Paralympian Ben Tudhope has already won a medal at the games… was it a gold, silver or bronze medal?2.What bee behaviour made the honey even stronger at fighting germs?3.What country is Joanne going to for her racing career?4.What is it called when someone is both Deaf and blind?5.What part of the turtle did Josh fix with the dental supplies?Answers1.A silver medal. 2.The bees visited lots of different kinds of flowers. 3.Japan. 4.Deafblind. 5.It's shell.
Even though boutique studio clients are creatures of habit, stagnant class schedules can breed boredom over time. Done right, adding new formats sparks excitement and attendance. It's a smart balance of discipline and evolution. Get guidance on trying new class formats strategically in Episode 715: How to Test New Class Formats Without Losing Money. Lead with the ledger: tie new formats to a revenue goal or retention gap Guard the brand: ensure new formats align with your positioning and don't muddy it Pilot, not plunge: launch a minimum viable schedule with a defined trial window Protect payroll: incorporate into the existing schedule to avoid adding new expenses Define success early: set utilization benchmarks and a clear exit plan upfront Testing new formats should boost enthusiasm and revenue with low risk. Lead with a business mind, not just emotions. Make your next schedule update a calculated win with Episode 715. Catch you there, Lise PS: Join 2,000+ studio owners who've decided to take control of their studio business and build their freedom empire. Subscribe HERE and join the party! www.studiogrow.co www.linkedin.com/company/studio-growco/
This is the sixty-first episode in the Crypto Hipster's Curtain Calls Series, which includes 3–4-minute clips from Seasons 6-8. This compilation draws upon my conversations with:Lindsey Lim, board member @ Radix Foundation (2/10/2025, Season 8)Kathy Roberts, CEO @ Switch Reward Card (9/26/2024, Season 8)Amir Forouzani, Core Contributor @ Puffer Finance (7/19/2024, Season 7)John Vibes, Content Lead @ Somnia Network (1/20/2025, Season 8)
Today we discuss this new iteration of VPR, and if we think it can possibly capture the messiness, drama, and sincerity of our beloved OGs! What do you think???Send us an email: PATCPOD@gmail.comThis month on PATREON:3/1 Vanderpump Rules S1 Reunion3/8 Rupaul's Drag Race All Stars 2 Episode 5 “Revenge of the Queens”3/15 Smash S1 E12 “The Movie Star”3/22 Pillow Talk 3/29 Vanderpump Rules S1 Reunion Secrete LEAVE US A VOICEMAIL FOR OUR MAILBAG AND WE WILL PLAY IT ON AN EPISODE :)https://www.speakpipe.com/podandthecityLEAVE US A VOICEMAIL FOR OUR MAILBAG AND WE WILL PLAY IT ON AN EPISODE :)https://www.speakpipe.com//podandthecity Hosted on Acast. See acast.com/privacy for more information.
Another group of outstanding, even legendary local athletes are set to be inducted next month into the Hancock Sports Hall of Fame (at 13:58) --- NY Times bestselling novelist Steve Berry is out this month with his 20th thriller to feature fan favorite hero Cotton Malone... ''The Devil's Bible'' (at 24:23) --- Don't forget to spring forward this weekend... Why do we keep doing this twice every year? Let's Ask Google! (at 32:32) --- Another collection of delicious, easy-to-make recipes from Kyra's Kitchen (at 50:31)
According to national data, leukemia remains is the most common cancer in children under 15, over 90% of cases occur in adults. A new Yale study has identified a new class of drug to better target cases of aggressive leukemia. We spoke with Ruifeng Sun, the lead author on this study.For the full study: Yale Study Identifies a New Class of Drug Targets for Aggressive Leukemia | Yale Cancer Center
In this episode of Dead in Hip Hop, Rod and his guests dive into the latest beef between TI and 50 Cent. They discuss the origins of the beef, with TI calling out 50 Cent for not wanting to collaborate on a song, and 50 Cent's subsequent diss track. The conversation also touches on the current state of mainstream rap, with Rod and his guests sharing their thoughts on the decline of meaningful lyrics and the rise of commercialism. They also discuss the impact of social media on the music industry and the importance of staying true to one's art.See omnystudio.com/listener for privacy information.
Jeff and Christian welcome Jesse Norris from DayOne back to the show to discuss the huge new Sony State of Play, laying out many of Playstation's biggest upcoming releases, new content for a 26-year old masterpiece, and layoffs for Highguard.The Playlist:Jesse: High On Life 2, Mario Kart World, DK Bananza, GoW Sons of SpartaChristian: Mario Tennis Fever, Replaced DemoJeff: High on Life 2, Replaced DemoParting Gifts!
Clint Stoerner & Ron Hughley cuss & discuss what the expectations should be for Texans OC Nick Caley to improve. Plus the guys look at the remaining field of the AFC and how a new standard has stepped in. Then they also take a small look at the offseason.
We're back with another packed episode, covering all the latest Premier League headlines plus a round-up of key stories from across world football. We dive into the magic of domestic cups, spotlight the games to look forward to this weekend, and then tackle the big debate: who truly deserves the “world class” label?Using a strict definition, we break down which players have actually earned that status over the last few seasons — and ask the uncomfortable question: are we finally approaching a year where the sport moves on from the familiar GOATs of football?Plenty of takes, plenty of arguments, and no shortage of passion. Tune in and let us know who makes your world class list.
The Bangkok Podcast | Conversations on Life in Thailand's Buzzing Capital
Greg and Ed discuss Ed's new class at his Thai university: "Contemporary Thai Society in the Modern World." The guys have a laugh at the thought of a white guy from Ohio teaching young Thais about their own country, but Ed notes that he has been living in Thailand as an adult for 25 years, whereas his students are only 18-20 years old. One point for Ed! Further, there's considerable value to getting an 'outsider' view of one's own country. Greg admits that his knowledge of his own birth country is scant in many ways. Ed and Greg banter about different topics that should be covered. Ed notes that there are a few gimmes: the upcoming election is perfect fodder for the class, and the 'Middle Income Trap' is a much discussed problem in the development of the Thai economy. The guys weigh the pros and cons of discussing the darker side to Thai society, such gambling and prostitution, with Ed admitting he hasn't made up his mind yet. Greg talks about his brave attempt at a 'Facts About Thailand' quiz that Ed gave his students on the first day of class, and Ed scores his quiz. Greg got 36 questions out of 50 correct (apparently spot on with Greg's actual academic performance!). If you are interested in taking the quiz yourself, follow the link here. If you beat Greg's score, he'll personally send you a gift card for Central Department Store worth 10,000 baht!* *this is not even remotely true.
Many New Year's traditions are meant to bring prosperity in the months ahead, but America's relationship to wealth is complicated. As billionaires' influence has grown, so too has skepticism. In a recent Washington Post/Ipsos poll, 58% of respondents said billionaires' spending on campaigns is bad for the country. Lisa Desjardins discussed the intersection of money and politics with Beth Reinhard. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy
Many New Year's traditions are meant to bring prosperity in the months ahead, but America's relationship to wealth is complicated. As billionaires' influence has grown, so too has skepticism. In a recent Washington Post/Ipsos poll, 58% of respondents said billionaires' spending on campaigns is bad for the country. Lisa Desjardins discussed the intersection of money and politics with Beth Reinhard. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy
Lawmakers in the US have reintroduced a bipartisan bill to help commercial satellite owners and operators defend against growing cybersecurity threats to satellites. Satellite manufacturer K2 Space has raised $250 million in Series C funding at a $3 billion valuation. Fortastra has emerged from stealth and has raised over $8 million in seed financing, and more. Remember to leave us a 5-star rating and review in your favorite podcast app. Be sure to follow T-Minus on LinkedIn and Instagram. T-Minus Guest Elysia Segal brings us the Space Traffic Report from NASASpaceflight.com. Selected Reading Lawmakers revive satellite cybersecurity bill to shield commercial space systems from rising threats - Industrial Cyber K2 Space Raises $250M at $3B Valuation to Roll Out a New Class of High-Capability Satellites Strength Among the Stars: Fortastra Emerges to Build Maneuverable Spacecraft for National Security New Orders Signed With MBDA For Over 35m€- Avio NASA Selects Two Heliophysics Missions for Continued Development NASA JPL Unveils Rover Operations Center for Moon, Mars Missions Share your feedback. What do you think about T-Minus Space Daily? Please take a few minutes to share your thoughts with us by completing our brief listener survey. Thank you for helping us continue to improve our show. Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at space@n2k.com to request more info. Want to join us for an interview? Please send your pitch to space-editor@n2k.com and include your name, affiliation, and topic proposal. T-Minus is a production of N2K Networks, your source for strategic workforce intelligence. © N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, Andreas Munk Holm sits down with Ole Lehmann to explore the rise of the solopreneur movement, what AI unlocks for solo founders, and how blockchain may finally have its moment as the infrastructure layer for AI. Ole also unpacks his new initiative, Built in Europe, and why he's betting on a future where ambitious company builders thrive without moving to the U.S.Here's what's covered:00:52 Ole's Journey: From Music Production to Crypto to AI Education03:57 Crypto Disillusionment & the Promise of Blockchain Infrastructure10:08 Inside the Solopreneur Mindset: Freedom, Curiosity & Leverage16:32 Content Market Fit > Product Market Fit: A New Way to Build21:18 Why Interest Graphs Beat Follower Counts in 202528:43 A New Class of Founders—and the Portfolio Play to Back Them39:10 How AI Tools Empower a One-Person Media Company43:31 Building in Europe: More Than a Narrative Play47:05 The Cultural and Regulatory Hurdles Still Holding Europe Back50:08 Why European Tech Founders Need to Enter the Political Arena
What if America's “anti-intellectualism” isn't a decline in smarts but a culture built to distrust theory? We trace that paradox from Puritan moral rigor and pragmatist “cash value” truths to the postwar professional class that speaks in a neutral tone while hiding its class origins. With Hofstadter, Lasch, and Gouldner as our guides, we unpack how speech codes, funding models, and media ecosystems shape who gets to be an “intellectual” and whose knowledge counts.We dig into Lasch's portraits of turn‑of‑the‑century radicals—Jane Addams, Randolph Bourne, Lincoln Steffens—showing how bohemia, policy reform, and romantic revolt often masked a middle‑class distance from worker life. Hofstadter helps explain why theory gets cast as elitist, how evangelical charisma and “common sense” produce a populism that can slip into conspiracy, and why so many bright people end up suspicious of abstraction. Then Gouldner reframes the post‑WWII landscape: a technical‑professional new class whose legitimacy depends on universality, even as its language quietly excludes working‑class speech and experience.From there, we get practical. We compare elite “neutrality” to the hard realities of endowments and medical revenue, and we explore what counter‑publics look like now: labor clubs that teach Robert's Rules and strike strategy alongside Marx, Bourdieu, and Joe Burns. We talk code‑switching without erasing origins, and we sketch ways to build worker‑centered study that doesn't pander—spaces where rigor and relevance live together. Gramsci's “organic intellectual” still matters here: every worker thinks and theorizes, with or without credentials.If this resonates, help us grow the counter‑public: subscribe, share the episode with a friend who loves big ideas, and leave a review with one question you want us to tackle next. These are the primary readings we discuss:-The American Intellectual Elite by Charles Kadushin- Anti-Intellectualism in American Life by Richard Hofstadter - The New Radicalism in America: The Intellectual as Social Type by Christopher Lasch - The Future of Intellectuals and the Rise of the New Class by Alvin Gouldner- The Missing Generation: Academics and the Communist Party from theDepression to the Cold War by Ellen SchreckerSend us a text Musis by Bitterlake, Used with Permission, all rights to BitterlakeSupport the showCrew:Host: C. Derick VarnIntro and Outro Music by Bitter Lake.Intro Video Design: Jason MylesArt Design: Corn and C. Derick VarnLinks and Social Media:twitter: @varnvlogblue sky: @varnvlog.bsky.socialYou can find the additional streams on YoutubeCurrent Patreon at the Sponsor Tier: Jordan Sheldon, Mark J. Matthews, Lindsay Kimbrough, RedWolf, DRV, Kenneth McKee, JY Chan, Matthew Monahan, Parzival, Adriel Mixon, Buddy Roark, Daniel Petrovic
Think you need to go harder to get fitter? We make a different case: the people who win are the ones who keep showing up. After 30, muscle and VO2 max trend downward unless you fight back with smart strength training, purposeful conditioning, and daily movement. We break down a simple plan you can follow all year: three to five intentional sessions weekly, protein-forward nutrition, sleep that actually restores you, and a bias toward training you can repeat tomorrow.We also walk through our updated programming. “Sweat” delivers full-body, simple, 40–50 minute sessions designed for muscular endurance and metabolic conditioning without heavy complexity. Build Welded Warrior remains the backbone for year-round general physical preparedness, blending strength, mixed conditioning, and skill work that supports real life. For athletes eyeing HYROX, we explain how to layer goal-specific running intervals, aerobic base work, and event-focused sessions on top of group class to create the right stimulus without burning out.Expect straight talk on expectations for your 30s, 40s, and 50s—why you can outpace your untrained 20s, and why chasing old PRs from college may not serve you. We cover injury prevention through intelligent scaling, why long layoffs cost more as you age, and how community tools like WhatsApp groups, class caps, and clear policies keep training accessible and high quality for everyone. We close with key dates, fee updates to protect prime hours, and a heads-up on our limited annual paid-in-full special.If you're ready to trade six-week sprints for steady progress, press play, subscribe, and share this with someone who needs a nudge. Leave a review with your weekly consistency goal—how many intentional sessions will you hit next week?Follow us on Instagram here! https://www.instagram.com/doubleedgefitness/
What to listen for:Our hosts Robin Greubel and Stacy Barnett explore generalization as the foundation of reliable detection work.Together, they reveal generalization as extending far beyond simple obedience across locations. It encompasses odor variability, environmental context, behavioral chains, and handler presentation.They explain how explosive and narcotic sources vary like chocolate-cake recipes: different manufacturers, cutting agents, and absorption materials create distinct odor profiles.Dogs trained on limited sources may fail to recognize the "same" target odor prepared differently. That's why handlers must expose dogs to diverse training aids and seek out other teams' materials.Next, they talk behavioral generalization. Does "search" mean the same thing in a familiar training field versus a novel parking lot, rubble pile, or aircraft? Robin and Stacy stress that context cues (vehicles, wilderness, buildings) and environmental distractions require deliberate proofing so dogs maintain focus regardless of setting, weather, or ambient noise.Robin describes her area-search class methodology, which emphasizes that handlers can proof refind behaviors solo by generalizing the chain across handler positions. You could even do jumping jacks or lie turtle-like after falling into a hole.The goal is stimulus control, which means the cue triggers the behavior everywhere, every time.Our hosts warn against training disengagement by repeatedly working in overly distracting environments (woods full of "trail mix") without first building a clean chain in controlled settings like big-box stores with clean floors.If dogs routinely self-employ or search lackadaisically, handlers must assess whether hides exceed the dog's skill level, reinforcement is insufficient, or engagement was never properly conditioned.Their green-eggs-and-ham framework captures the essence of generalization: master the skill (row your boat), then generalize it everywhere (here, there, everywhere).Key Topics:Odor Generalization Across Sources and Absorption Materials (01:41)Training-Aid Availability and Pairing New Sources (04:56)Directionals and Platform Generalization (FEMA, Rubble Piles) (12:40)Training for Test vs. Application (Go-Outs, Distance, Body Language) (16:51)Area Search, Refind/TFR and Robin's New Class (18:50)Search Cue Stimulus Control in Blank and Novel Areas (20:45)Context Cues, Vehicles, and High-Likelihood Targets (23:38)Distraction Management and Clean Behavior Chains (37:45)Green Eggs and Ham: Progression Plans for Young Dogs (42:56) Resources:Study about the need for generalization in Explosives Detection DogsEpisodes with Dr. Lauryn DeGreeffRobin's Area Search/Wilderness Dog ClassStacy's course on Reading Pre-alert BehaviorMake sure to register for Stacy's upcoming term!We want to hear from you:Check out the K9 Detection Collaborative FB page and comment on the episode post!You can follow us for notifications of upcoming episodes, find us at k9detectioncollaborative.com
In the first half of the show, we discuss the newly elected female Democratic leadership, several reasons people dislike Trump, and how the president has been flip-flopping with his position on whether or not to allow SNAP benefit payoutsSupport the show: https://www.patreon.com/civiccipher?utm_source=searchSee omnystudio.com/listener for privacy information.
The New Class of Female Democratic Leadership Is Emerging. Hear more on this topic on today's podcast.See omnystudio.com/listener for privacy information.
Generative AI tools are changing software development, but how does that impact how we teach it? In this episode of Stories from the Hackery, NSS Founder John Wark sits down with Lead Instructor Steve Brownlee to discuss the intentional way generative AI has been integrated into NSS's full-stack software development bootcamp. They cover NSS's AI journey: from initially coaching students to use AI as a personalized learning assistant (and not for code generation) to teaching "reverse engineering" workshops where students learn to prompt AI to build projects they just completed themselves. Steve shares how NSS remains focused on building strong foundational skills first, emphasizing that students must know how to write good code before they can effectively review and manage AI-generated code. They also look ahead at new professional development courses, like Agentic AI for Developers, and what the rise of AI Engineering means for the tech industry. SHOW NOTES: 04:00 The Evolution: Integrating GenAI into the Bootcamp 07:17 Using NotebookLM as a Personalized Learning Tool 09:58 Creating Sample Data with an LLM 11:31 The "Reverse Engineering Workshop": Learning to Prompt 18:27 Using AI to Complete Features in a Final Project 23:25 The Most Important Skill: Learning How to Learn 25:09 Beyond the Bootcamp: The Agentic AI for Developers Workshop 30:48 How Agentic AI Works: Your "Coding Intern" 35:24 What's Next? A New Class on Debugging Existing Code 43:09 The Future: What is AI Engineering? 51:38 Final Thoughts: An Exciting Time for Developers LINKS: ChatGPT: https://chatgpt.com/ NotebookLM: https://notebooklm.google/
Eric Fischer, a professor at Dana-Farber Cancer Institute, on creating a new class medicines -- targeted protein degraders.
The start of the new school year brings the usual set of challenges for students as they navigate new schedules, lesson plans and social dynamics. Those changes can also take a toll on a student’s mental health. A survey conducted in 2023 by the Centers for Disease Control and Prevention found, for example, that 40% of high school students nationwide reported depressive symptoms - an increase of more than 10% since 2013. Former U.S. Surgeon General Dr. Vivek Murthy issued an advisory in 2021 warning about worsening youth mental health, exacerbated by the pandemic and excessive use of social media. The Ballmer Institute for Children’s Behavioral Health at University of Oregon is working to help address this crisis of youth mental health. Launched in 2022, the institute is pioneering the first program of its kind in the nation to educate and train a new class of healthcare workers: child behavioral health specialists. The 4-year program provides an alternative to the additional years and cost a student would typically have to spend in graduate school to become, for example, a school psychologist or social worker. Instead, the undergraduates in the program obtain 700 hours of applied training that starts their junior year with internships at Portland area schools, clinics and community organizations. While they can’t provide diagnoses or conduct psychological evaluations, the interns can help prevent and mitigate behavioral health challenges by teaching, for example, problem-solving strategies or coping skills kids can use during stressful situations. Joining us for more details are Cody Ghion, an assistant clinical professor at UO’s Ballmer Institute for Children’s Behavioral Health; Sophia Morgan, a UO senior and child behavioral health intern who is currently working at a high school in Portland for students in recovery from substance use; and Anne Libby, who is also a UO senior and child behavioral health intern currently working at a pediatric clinic in Hillsboro.
We left feudalism, with it's reciprocal obligations, rigid class structures, and lack of social mobility behind hundreds of years ago, right? Jodi Dean, professor of political science at Hobart and William Smith Colleges, argues that we might be headed back to the future into a system she terms as "neofeudalism."
Sponsor Details:This episode of Space Nuts is brought to you with the support of Insta360. Capture your adventures with their latest game-changer, the GOUltra. For a special Space Nuts offer, visit store.insta360.com and use the promo code SPACENUTS at checkout. Help support Space Nuts and get a great deal. Win/win!And NordVPN. Just visit nordvpn.com/spacenuts for the best price and 4 extra moths for free.Life on Mars? New Black Hole Stars and Quasi MoonsIn this riveting episode of Space Nuts, hosts Andrew Dunkley and Professor Fred Watson delve into some of the most exciting developments in astronomy. From the tantalising possibility of past life on Mars to the discovery of a new class of black hole stars, this episode is brimming with cosmic revelations that will keep you on the edge of your seat.Episode Highlights:- Evidence of Life on Mars: The hosts discuss recent claims about the discovery of biological processes on Mars, focusing on a rock sample named Chavaja Falls. They explore the implications of "leopard spots" and the potential for past life, while emphasising the need for further analysis and sample return missions.- New Class of Black Hole Stars: Andrew and Fred Watson examine the evolving understanding of red dots detected by the James Webb Telescope. What was once thought to be galaxies may actually be gigantic stars with black holes at their centres, reshaping our understanding of the early universe.- Quasi Moons: The episode wraps up with a discussion on the latest quasi moon discovered orbiting Earth. The hosts explain the unique characteristics of these objects and their temporary nature, as well as the implications for future studies.For more Space Nuts, including our continuously updating newsfeed and to listen to all our episodes, visit our website. Follow us on social media at SpaceNutsPod on Facebook, X, YouTube Music, Tumblr, Instagram, and TikTok. We love engaging with our community, so be sure to drop us a message or comment on your favourite platform.If you'd like to help support Space Nuts and join our growing family of insiders for commercial-free episodes and more, visit spacenutspodcast.com/aboutStay curious, keep looking up, and join us next time for more stellar insights and cosmic wonders. Until then, clear skies and happy stargazing.Got a question for our Q&A episode? https://spacenutspodcast.com/amaBecome a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.
Bret Taylor is the CEO of Sierra and Chairman of the Board of OpenAI. He previously served as co-CEO of Salesforce. I sat down with Bret to explore how the AI revolution compares to previous platform shifts and what it means for both startups and incumbents navigating this transition. (00:00) Introduction and Recent Milestone (00:38) AI Market and Historical Comparisons (02:30) Competitive Landscape and Business Models (06:02) Outcome-Based Pricing and Value Creation (13:52) Technological Shifts and Business Transitions (26:32) Adoption Challenges and Forward Deployed Engineering (37:21) Early Investment in Snowflake and Cloud Strategy (38:02) Enterprise Software Market Dynamics (38:38) AI Agents and Implementation Costs (41:06) Democratization of Software Development (43:35) The Future of Software Companies and AI Agents (49:36) Consumer Behavior and AI Agents (58:56) The Role of AI in Customer Experience (01:01:25) Career Advice in the Age of AI Executive Producer: Rashad Assir Mixing and editing: Justin Hrabovsky Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
[Bungacast is on holiday, so we're unlocking/re-releasing a July 2021 episode that was previously only available to higher-tier subscribers] We discuss Michael Lind's The New Class War. Lind identifies new lines in the class war, between working class and managerial overclass, between those in the "heartlands" and those in the "hubs". How convincing is this account? What is his critique of technocratic managerialism and its symptom, populism? How convincing - and realistic - is his solution of "democratic pluralism"? And is this only achievable as a result of a new cold war with China?
Today's show features: Luke Reymer, Student at Automotive Business School of Canada Quin Garcia, Managing Director at Autotech Ventures This episode is brought to you by: OPENLANE – The world's best online dealer marketplace for used cars. This August, OPENLANE is spinning up an entire month of excitement with DealerFest 2025. The more you buy and sell, the bigger prizes you earn. Never used OPENLANE before? New dealers can earn up to $2,500 in credits. Learn more at openlane.com/dealerfest. Interested in advertising with Car Dealership Guy? Drop us a line here: https://cdgpartner.com Interested in being considered as a guest on the podcast? Add your name here: https://bit.ly/3Suismu Check out Car Dealership Guy's stuff: CDG News ➤ https://news.dealershipguy.com/ CDG Jobs ➤ https://jobs.dealershipguy.com/ CDG Recruiting ➤ https://www.cdgrecruiting.com/ My Socials: X ➤ https://www.twitter.com/GuyDealership Instagram ➤ https://www.instagram.com/cardealershipguy/ TikTok ➤ https://www.tiktok.com/@guydealership LinkedIn ➤ https://www.linkedin.com/company/cardealershipguy/ Threads ➤ https://www.threads.net/@cardealershipguy Facebook ➤ https://www.facebook.com/profile.php?id=100077402857683 Everything else ➤ dealershipguy.com