Podcasts about Norepinephrine

Methylene Blue has been getting a lot of attention lately, and I wanted to cut through the noise with some real science. I sat down with my friend Dr. Scott to talk about why this compound might actually be a powerful and supportive tool for mitochondrial health, brain function, and overall vitality.Some recent conversations have raised questions about Methylene Blue, so we're here to bring clarity and context. In this episode, we break down the research, talk through safety considerations, and explore why Methylene Blue might be one of the most underrated interventions out there.TOPICS DISCUSSED→ What are the benefits of Methylene Blue for the brain and cells?→ What does current research say about Methylene Blue?→ Who shouldn't use Methylene Blue, especially with SSRIs?→ How does Methylene Blue boost energy and clarity?→ Is Methylene Blue safe for brain and energy support?TIMESTAMPS→ 00:00:00 - Introduction → 00:01:55 - Is Methlyne Blue dangerous? → 00:05:54 - Methlyne Blue dosing → 00:08:03 - Troches & titration → 00:09:57 - Therapeutic benefits of Methylene Blue→ 00:15:05 - Cells with the most mitochondria → 00:18:40 - SSRIs and other Methylene Blue contraindications→ 00:23:39 - Supplement cycling→ 00:27:49 - SSRI's dopamine and Norepinephrine→ 00:34:30 - Methylene Blue & metabolism → 00:35:29 - Mitochondria dysfunction & stress → 00:38:21 - The dangers of blue light → 00:43:30 - The science of Methalyne blue → 00:47:41 - Daily Methalyne Blue usage → 00:51:43 - Red light and Methalyne Blue  → 00:53:12 - Methylene Blue, energy, & sleep → 00:55:07 - How to take Methylene Blue→ 00:59:13 - Resources for clinicians and practitioners SPONSORED BY:→ Troscriptions | There's a completely new way to optimize your health. Give it a try at troscriptions.com/SARAHK, or enter SARAHK at checkout for 10% off your first order.SHOW LINKS:→ The Ultimate Methylene Blue Episode - What Is It & Can It Give Me More Energy? Dr. Scott SherrCheck Out Dr Scott: → Troscriptions | There's a completely new way to optimize your health. Give it a try at troscriptions.com/SARAHK, or enter SARAHK at checkout for 10% off your first order.→ Podcast→ Instagram This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________My free product guide with all product recommendations and discount codes:https://s3.amazonaws.com/kajabi-storefronts-production/file-uploads/sites/2147573344/themes/2150788813/downloads/eac4820-016-b500-7db-ba106ed8583_2024_SKW_Affiliate_Guide_6_.pdfCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesSign up for my newsletter to get special offers in the future! -https://www.sarahkleinerwellness.com/contact

Jason Yeatman is an expert in the neurobiology of literacy whose lab is fostering a virtuous research cycle between academia and school communities, aligning scientific inquiry with real-world needs of students, parents, and educators. His lab has developed ROAR – the Rapid Online Assessment of Reading—a gamified, web-based dyslexia screening tool. ROAR provides fast, precise, and scalable assessments, helping educators identify and get support to struggling students. We're aligning cutting-edge reading science with the challenges teachers face every day, Yeatman tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Listen to the end to hear a question from one of our listeners for Professor Renee Zhao, as well as Professor Zhao's response. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Jason YeatmanRapid Online Assessment of Reading (ROAR)Jason and his team just launched ROAR@Home BETA, a parent research portal. Any parent who listens can sign up for ROAR here - https://roar.stanford.edu/signup/Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Jason Yeatman, a professor of pediatrics education and psychology at Stanford University.(00:03:12) Why Reading?Why Jason dedicated his career to studying reading acquisition.(00:04:12) Are We Built to Read?How reading is a relatively new invention using older brain systems.(00:06:41) Reading as a ContinuumWhether reading ability is distributed like other genetic human traits.(00:07:53) Defining DyslexiaReframing dyslexia as a label for support, not a binary diagnosis.(00:10:19) Phonological AwarenessUnderstanding how speech sound recognition underpins reading.(00:13:37) Nature vs. NurtureThe influence of both genetics and environment in reading ability.(00:16:40) The Origin of ROARAn online reading assessment tool created during the pandemic.(00:19:06) ROAR's EffectivenessThe accuracy in which ROAR can assess reading capability.(00:22:45) Reading Interventions That WorkExpanding support with evidence-based interventions for all ages.(00:25:25) Personalized DiagnosesTailoring interventions based on detailed individual skill diagnostics.(00:26:36) Scaling ROARScaling ROAR via an academic research-practice partnership model.(00:29:34) Infrastructure Behind ROARThe team and technology required to scale ROAR in schools.(00:31:54) Future of Reading AssessmentExpanding ROAR to include other dimensions of reading development.(00:33:44) Reading Across LanguagesWhy English poses more reading difficulties than many languages.(00:35:34) Listener Q&ANew segment answering audience questions from past episodes.(00:37:46) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Neurobiologist Jamie Zeitzer is an expert on sleep – or, more accurately, an expert on why so many can't sleep. He notes that, ironically, it's often anxiety about sleep that prevents good sleep. In short, we lose sleep over lost sleep. Wearables and other tools can help but only to a point, and medications do not induce natural sleep. Instead, he counsels consistent routines, less stimulation at bedtime, and cognitive behavioral therapy to reduce worry about insomnia. Unfortunately, you can't work harder to get better sleep – you have to learn to relax, Zeitzer tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Jamie ZeitzerConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Jamie Zeitzer, professor of psychiatry and behavioral sciences at Stanford University.(00:03:12) Understanding Circadian RhythmsHow the biological clock regulates sleep and other body functions.(00:04:57) The Mystery of Sleep's PurposeWhat is still unknown about the fundamental need for sleep.(00:06:00) Light and the Circadian ClockThe impact light exposure has on the body's internal sleep timing.(00:08:13) Day and Night Light ContrastThe importance of creating a light-dark contrast for healthy rhythms.(00:11:18) Phones, Screens, and the Blue LightWhether blue light from screen use affects sleep quality.(00:13:49) Defining and Diagnosing Sleep ProblemsHow stress and over-focus on sleep quality worsen insomnia.(00:16:02) Sleep Anxiety and WearablesThe psychological downsides of sleep data from tracking devices.(00:17:14) CBT-I and Rethinking InsomniaMentally reframing sleep with cognitive behavioral therapy for insomnia.(00:21:21) Desynchronized Sleep PatternsStudying student sleep patterns to separate circadian vs. sleep effects.(00:23:49) Shift Work and Circadian MisalignmentThe difficulty of re-aligning circadian clocks in rotating shifts.(00:26:26) Effectiveness of Sleep MedicationsThe various drugs used to promote sleep and their pros and cons.(00:29:46) Circadian “Sleep Cliff” and MelatoninThe brain's “wake zone” before sleep and the limited effects of melatonin.(00:32:52) Do's & Don'ts for Better SleepAdvice for those looking to improve their sleep quality.(00:34:55) Alcohol and Caffeine EffectsHow metabolism influences the effects of alcohol and caffeine on sleep.(00:37:24) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

N Engl J Med 1996;334:1349-1355Background Before 1990, the prevailing idea held that the negative inotropy of beta-blockers would harm patients with impaired systolic function. Yet part of the progression of systolic heart failure involved over stimulation of the sympathetic nervous system. Norepinephrine can exert adverse effects on the circulation, both directly and indirectly. Smaller trials of beta-blockers in systolic heart failure found trends for benefit with beta-blockers, however, a mortality benefit had not yet been proven. The U.S. Carvedilol Heart Failure Study aimed to study mortality in patients with heart failure with a reduced ejection fraction.Cardiology Trial's Substack remains free of industry ads because of your support. Thank you. Please consider becoming a free or paid subscriber.Patients The study enrolled 1094 patients with chronic heart failure symptoms for at least 3 months, LVEF ≤ 0.35%, at least 2 months of treatment with diuretics and an angiotensin-converting enzyme (ACE) inhibitor (if tolerated). Treatment with digoxin, hydralazine, or nitrates was permitted but not required.Exclusion criteria were extensive and important to understand. These included any recent major cardiac events or surgery within the previous 3 months, uncorrected valvular disease, active myocarditis, sustained VT or higher degrees of AV block not controlled by pacing, systolic blood pressure of more than 160 or less than 85 mm Hg or diastolic blood pressure of more than 100 mm Hg, clinically significant kidney or liver disease or use of calcium-channel blockers, adrenergic agonists/antagonists, or class IC/III antiarrhythmic agents. Patients receiving β-adrenergic agonists or antagonists (presumably for another indication) were not enrolled.Baseline Characteristics The results of this and other beta-blocker trials in heart failure will be clear. One of the most important points for translating this evidence to patients will be the baseline characteristics. It is vital to understand who these patients were.The mean age was 58 years and approximately 76% were male. Most patients had mild to moderate heart failure, with 53% in NYHA Class II, 44% in Class III, and only 3% in Class IV. The etiology of heart failure was nearly evenly split between coronary artery disease (47%) and nonischemic cardiomyopathy (53%). Patients had significantly impaired cardiac function with a mean LVEF of 0.23. The mean six-minute walk distance ranged from 386 to 390 meters. Hemodynamic parameters were relatively stable, with mean systolic blood pressure of 116 mmHg, and mean heart rate of 83-84 beats per minute. Most patients were receiving standard heart failure therapy at baseline, including digitalis (90-91%), loop diuretics (95%), and ACE inhibitors (95%), while approximately one-third (32%) were on direct-acting vasodilators.Trial Procedures Patients were assessed for eligibility during a 3-week screening period during which exercise capacity was assessed with a 6-minute walk test. Notable was that these were outpatients able to complete a 6-minute walk test. Enrollment was stratified to one of four treatment protocols on the basis of the patients' performance on the exercise test: patients able to walk between 426 and 550 m when tested were assigned to the mild-heart-failure protocol; those able to walk between 150 and 425 m were assigned either to the moderate-heart-failure protocol or to a dose-ranging protocol, depending on the location of the study center; and those able to walk only less than 150 m were assigned to the severe-heart-failure protocol.After this base-line testing, all patients received 6.25mg of carvedilol twice daily for two weeks in an open-label run-in period. Those who tolerated this initial dose were then randomized to receive either placebo (n=398) or carvedilol (n=696) on a double-blind basis, in addition to their usual medications.The allocation ratio (carvedilol:placebo) was 2:1 in the mild and severe heart failure protocols and 1:1 in the moderate heart failure protocol. The dose was gradually increased to target levels of 25-50mg twice daily over 2-10 weeks, followed by maintenance therapy for an additional 6 months (12 months for mild heart failure).Endpoints At the time of trial planning, the original intent was safety. That is, to show that carvedilol did not increase mortality. The original intent was to enroll 1100 patients. As smaller trials on beta-blockers were published, the statistical plan included the possibility of beta-blocker benefit. The trialists therefore planned two sided statistical analysis.Cumulative survival curves were constructed as time-to-first-event plots by Kaplan–Meier survivorship methods and differences between the curves were tested for significance by the log-rank statistic with use of a Cox proportional-hazards regression model (which included the protocol as a covariate).Results Median follow-up was only 6.5 months due to early termination for benefit. The patients mean total daily dose of carvedilol was 45±27 mg. Overall mortality was 7.8% in the placebo group vs. 3.2% in carvedilol group. The relative risk reduction from carvedilol vs placebo was 65% (95% CI, 39-80%; p

Show notes at pharmacyjoe.com/episode1024. In this episode, I'll discuss the use of adjuvant midodrine in patients with septic shock. The post 1024: Adjuvant Midodrine Lowers Norepinephrine Dose But Not Length of Stay in Patients With Septic Shock appeared first on Pharmacy Joe.

Ever feel like your body is working against you no matter how “healthy” you try to be?That's exactly where I found myself—exhausted, bloated, moody, wired yet tired, and frustrated that nothing was working. So I decided to dig deeper. I ran a DUTCH hormone test on myself… and let's just say, the results were humbling.In this raw and honest episode, I'm walking you through what my DUTCH test revealed—and why I now lovingly refer to my hormones as a bit of a “dumpster fire.”Here's what I discovered:

Episode Highlights With Dr. Erika GrayImportant perspective about genetics and how to use this information for the biggest advantageThe nuance when it comes to children and genes Genes do not exist in isolation and why focusing on one gene is not helpfulHow understanding genetics helped her teens (and mine)What COMT is and how this comes into play with influencing our worldviewFast COMT break down dopamine and norepinephrine faster (linked to moving around, not sitting still, etc.)How this understanding of genetics can relate directly to how we parent Yet another reason protein is so important, especially for kids and teens Genes related to serotonin and dopamine and neurotransmittersWe have 2-5 lbs of bacteria in our gut, and there is a gene called FUT2 that ties to lower levels of bifidobacteria, and this can be linked to anxiety, longevity, and moreUnderstanding choline genes and why this is a game changer for so many people, and this is critical for pregnancy and brain development Some caveat around MTHFR and why we might be overdoing our response to thisSerotonin-related genes to look at if you get your kids' genes testedWhat BDNF genes can tell youMC4R is a snacking gene, and how to understand thisBitter taste receptor genes and how these can make kids more pickyResources We MentionMy Toolbox Genomics - Use code wellnessmama for a discountKion Aminos

Can cold exposure improve your mental health? In this episode, we explore the science behind cold therapy methods like ice baths, cryotherapy, cold-water swimming, and cold showers. Backed by research, we dive into the physiological and psychological effects of cold exposure, including its impact on mood, anxiety, dopamine, norepinephrine, and stress resilience. We discuss historical practices, benefits for mental and physical health, and common misconceptions around claims like immune boosting and inflammation reduction. Learn practical tips, safety precautions, and how cold immersion could fit into your mental health or wellness routine. Whether you're curious about the Wim Hof Method, the dopamine-boosting effects of cold plunges, or the latest studies on cold exposure's antidepressant potential, this episode offers insights you won't want to miss.   By listening to this episode, you can earn 1.5 Psychiatry CME Credits. Link to blog. Link to YouTube video.

Discover the transformative powers of the brain with our incredible guest, Brandon Davis. Today, we uncover the science behind neuroplasticity, the incredible impact of cold plunges, and how neurofeedback can reshape mental well-being. Join us as Brandon shares poignant stories, groundbreaking therapies, and personal experiences that highlight the astonishing resilience and adaptability of the human mind.  This episode is a must-listen for anyone seeking to unlock their fullest potential and find freedom through mental and physical renewal..   00:00 - Introduction 06:09 Cold exposure aids brain rewiring and visualisation. 12:22 Joined the military for structure, purpose; became a pilot. 23:34 Mindfulness drastically reduced negative thoughts duration. 30:58 Norepinephrine solidifies memory with environmental factors. 35:42 Beliefs shape reality; self-empowerment starts early. 37:51 Cold plunge immediately impactful; neurofeedback rewires brain. 45:12 Dopamine-driven brain training for psychological improvement. 52:08 Preparing for a cold plunge with a guided protocol. 58:11 Comfort and gratitude change reactions to negativity. 01:01:28 Visualise identity; body believes; become it.   About your host Aleks: Aleks Chojnacka has been on a health journey for many years, learning so much along the way. At a young age, she experienced debilitating fatigue but was unable to solve it through a Western medicine approach. Eventually, she turned to alternative methods and experienced a transformative shift in her health. By discovering the power of the mind, body, and spirit connection through different tools and practices, she was able to regulate her nervous system and step back into the most energized version of herself. Knowing that so many others have had similar struggles, Aleks pursued credentials in health coaching and breathwork and started her own wellness studio. Detox House provides people with what Aleks found to be the MOST effective tools in her own healing–the trifecta of saunas, cold plunges, and breathwork. Her end goal is to empower individuals to get rid of the things that no longer serve them, whether a difficult mindset or physical ailment, and step back into their truest selves so they can live their most joyful lives. Aleks' dedication to sharing these life-giving practices establishes Detox House as a community marked by positivity and transformation. Find out more about Detox House: https://detox-house.com/ Connect with Aleks: Instagram: https://www.instagram.com/thedetoxhouse/ About Brandon D. Davis Brandon D. Davis is the founder of The Davis Focus Project, a Non-Profit for Human Performance. While serving in the Army, Brandon was the Distinguished Honor Graduate of his flight school class and went on to become a Black Hawk instructor pilot in the 160th Special Operations Aviation Regiment.   Retiring from the military this year, Brandon is the owner of Adrenaline Luxury Rentals, the largest luxury and exotic rental car company in Tennessee, and prior owner and creator of Freedom Flyers Academy in Hopkinsville, KY. Brandon formed The Davis Focus Project after surviving a 3-year deep depression. During this time of hardship, he studied psychology and human performance to devise a plan to recover and regain his resiliency.   Realising how powerful these scientifically proven modalities were in aiding his own recovery, Brandon was inspired to create a Non-Profit to help others in their path to recovery and maximizing human performance.    Brandon is a man of faith and dedicated to serving the community. He prides himself in being direct, honest, efficient and a man of his word. Brandon lives in Nashville, TN with his wife, Chelsea, and his two daughters, Carson and Brittany. Find out more: https://www.thedavisfocusproject.com  

ADHD has been well understood in the classroom. For a long time, ADHD has been well understood in children and treated for optimal growth in their maturing years. What about adults? What does ADHD look like later in life? How should we understand its effect on life and relationships? How do we treat the disorder for optimal living in the mature years?    Show notes:  What is ADHD?  ADHD stands for Attention Deficit and Hyperactivity Disorder. It is a brain disorder. Individuals with ADHD might find it difficult to focus, stay on task, calm and quiet themselves.  What is the neuroscience behind ADHD?  ADHD is a delay in brain development. When certain neurotransmitters are unable to be balanced in the brain, ADHD will result. Two significant neurotransmitters out of balance in the ADHD brain are dopamine and norepinephrine. Dopamine promotes focus, motivation and reward. Norepinephrine regulates judgement and control.  When does ADHD show up?  When ADHD is present, it will show up in childhood. However, the disorder does persist into adulthood. How ADHD is manifested through the aging process differs. For example, hyperactivity which manifests itself outward in youth is still present in an adult but is often experienced more inwardly. ADHD adults have an advantage over ADHD children because they have more control over their environment. For example, the classroom is imposed on the life of a child but a career conducive to an ADHD adult is within their control.  How is ADHD diagnosed?  ADHD can be diagnosed at any point in a person's life. Two methods for diagnosis are available:  A clinical diagnosis happens when a professional evaluates the presence of the disorder by interview. Through a holistic battery of questions to the client as well as those who live and work closely with them an ADHD determination can be given.   A neuro-psychological evaluation can be given by a professional. This approach includes cognitive skills assessments.  It is important to note that before “ruling in” ADHD, many things need to be “ruled out.” There are many confounding matters such as anxiety and depression that conflate the ADHD diagnosis.     If someone suspects ADHD, should they get a diagnosis?  Yes and no.  Knowing what is contributing to pain is helpful in working through and finding remedies for it. If what an individual suspects to be ADHD is causing ongoing pain in their relationships and responsibilities, a diagnosis has purpose.   If very mild ADHD is present but not causing ongoing life disruption and pain, then a diagnosis may not be necessary.  What are some “helps” for those with ADHD?  Two routes can be taken for assisting those with ADHD:  Therapy can be helpful in learning good coping, lifestyle management and relationship skills. These skills can help mitigate the pain ADHD can cause.  Because ADHD is an imbalance of neurotransmitters, medication is available to help bring balance where imbalance is present.  Is having ADHD only negative in a person's life?  Fortunately, many have lived well with their ADHD. Their brain is able to take in a lot of stimuli at the same time. Their activated state can produce many benefits such as creativity and ambition. 

Send us a text- On-Demand Programme Link - https://mailchi.mp/bb2a7b851246/kairos-centreI like this article by Luke Gilkerson (as long ago as 2012), when he interviewed a Neuroscientist called Dr William Struthers - author of the book "How pornograpghy Hijacks the male brain"Dr Struthers explains what hormones and neurotransmitters are involved in porn addiction. Hope you find this intriguing and interesting:Testosterone: Testosterone drives a man's interest in sex. Fantasizing or viewing images, will release testosterone. This creates an intense and growing desire for sexual release.Norepinephrine: Is the brain's version of adrenaline. It is responsible for making us alert, help us to wake up, fall asleep and to stay alert upon the task in hand. During sexual arousal, it alerts the brain to “Something is about to happen and we need to get ready for it.” It “ramps up” the brain for activity.Serotonin: is a neurotransmitter tied to mood. Low serotonin levels can lead to struggling with depression. Although not specifically tied to sex, when sexual arousal happens, serotonin is released in small packets in the brain. It elevates the overall sense of excitement and enjoyment. Dopamine: Dopamine is not sexually specific (like testosterone). The brain is wired in such a way that it wants to remember where our natural drives are satisfied; Just like when we are thirsty, we know where to find water. The brain is wired to place significance on the place we found it so we can return to that place. Dopamine is the drive-related neurotransmitter that accomplishes this mental focus for us. When we have a dopamine surge, the sense we feel is, “I have got to have this thing. This is what I need right now, and here's where I get it.” Dopamine is the way your brain remembers how sexual craving was satisfied in the past, pushing you to seek out the same thing in the future. For the porn addict, Dopamine creates a sharp focus on finding porn.Endogenous Opiates: The body produces natural forms of opium called endorphins. Endorphins relieve pain. Like opium, it gives a euphoric feeling of well-being. When a man ejaculates, these opiates create a “high” and a wave of pleasure coursing over the body.Oxytocin and Vasopressin: These are hormones released in the brain in response to ejaculation. They help lay down the long-term memories for the cells. They “bind” a person's memories to the object that gave the sexual pleasure. When someone returns to pornography again and again, this cements a “relationship” with what he has seen.So, bringing them all together: As a male goes through his day, testosterone levels begin to increase as he stares at the source of his sexual attraction or fantasizes. He creates a desire for sexual release. Norepinephrine is being released, making his brain more and more primed and ready for action. Serotonin is also released, creating a sense of excitement about the pending sexual “payoff.” Dopamine is focusing the mind, telling the brain, “You have to go back to the attraction where that reliable payoff is at.” As he seeks out the attraction, he masturbates, releasing endogenous opiates into the brain, giving him a rush of euphoria. Oxytocin and vasopressin are released, binding him to the images he sees.Repeat, beckons in the immediate future – when it will all start again and again, and again and again….Until the cycle is interrupted. Interesting hey?No quick fixes guys. Quick fixes does not exist!Want to know more? Click the link and come get me. Get the help you need:

Send us a textIn this insightful episode of Wildly Curious, hosts Katy Reiss and Laura Fawks Lapole dive deep into the world of ADHD. From the brain's unique wiring to the day-to-day challenges and incredible strengths of those with ADHD, this episode explores it all. Learn about the science behind impulsivity, forgetfulness, and hyperfocus, as well as how reframing ADHD can uncover the power and potential within. Whether you have ADHD, love someone who does, or simply want to learn more, join Katy and Laura for a heartfelt and humorous exploration of what it means to live with an ADHD brain.Perfect for anyone curious about neuroscience, personal growth, or strategies for thriving with ADHD!Want to see behind the scenes and unedited footage?!

We recently implemented a "push-dose" norepinephrine protocol at MCHD and have already learned some valuable lessons. Join us for some vasopressor pharmacology and protocol review, accompanied by some of our new teaching points that have arisen following the protocol's release into the wild. REFERENCES: 1. Berkenbush, M., Singh, L., Sessa, K., & Saadi, R. (2024). Scoping Review: Is Push-Dose Norepinephrine a Better Choice? The western journal of emergency medicine, 25(5), 708–714. 2. Permpikul, C., Tongyoo, S., Viarasilpa, T., Trainarongsakul, T., Chakorn, T., & Udompanturak, S. (2019). Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A Randomized Trial. American journal of respiratory and critical care medicine, 199(9), 1097–1105.

In this episode of the PFC Podcast, Dennis and JP Kolcun, a neurosurgery resident, delve into the complexities of spinal trauma. They discuss the differences between spinal shock and neurogenic shock, the assessment and management of penetrating and blunt spinal injuries, and the critical importance of addressing secondary injuries. The conversation emphasizes the need for timely intervention and the nuances of trauma care in both field and hospital settings. This conversation delves into the complexities of spinal cord injury treatment, emphasizing the importance of timely surgical decompression, understanding spinal cord perfusion, and the role of intrathecal pressure. The discussion highlights the need for optimizing spinal cord perfusion pressure and the implications of using vasopressors. Innovations in treatment, including the potential for intrathecal medication delivery and advancements in brain-computer interfaces, are explored as future avenues for improving patient outcomes. Takeaways Spinal shock is a neurologic phenomenon, while neurogenic shock is hemodynamic. Penetrating spinal cord injuries are often more severe than blunt injuries. Immediate stabilization and ABCs are crucial in trauma care. Understanding the difference between spinal shock and spinal cord injury is vital. Secondary injury can worsen outcomes if not addressed promptly. Timely decompression of the spinal cord can improve recovery chances. Assessment of spinal stability is essential in blunt trauma cases. The presence of a bulbocavernous reflex can indicate spinal cord injury. Norepinephrine is preferred for treating neurogenic shock. Avoid hypotension to prevent further complications in spinal injuries. The timing of surgical decompression can significantly impact recovery. Surgical decisions must consider the overall health of the patient, not just the injury. Spinal cord perfusion is critical for recovery post-injury. Intrathecal pressure varies and can affect spinal cord perfusion. Targeting spinal cord perfusion pressure may improve outcomes over traditional MAP goals. Vasopressors can constrict blood vessels, potentially reducing perfusion to the spinal cord. Innovative treatments, such as lumbar drains, can enhance spinal cord perfusion. Research is ongoing into the use of intrathecal medications for spinal cord injury. The ultimate goal is to improve quality of life for spinal cord injury patients. Advancements in technology may lead to breakthroughs in treating chronic spinal cord injuries. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠

This week, during the Metabolic Classroom lecture, Dr. Ben Bikman examines the metabolic consequences of medications used for mental health, such as antidepressants and anti-anxiety drugs. Ben highlights the close connection between mental health disorders like depression and anxiety with metabolic issues, particularly insulin resistance and type 2 diabetes. These medications, while effective for managing mental health symptoms, often lead to metabolic side effects such as weight gain and insulin resistance, complicating the relationship between mental and metabolic health.Dr. Bikman reviews key neurotransmitters—serotonin, dopamine, and norepinephrine—that influence both mental and metabolic functions. Serotonin helps regulate mood and appetite but can promote fat accumulation and inhibit fat breakdown. Dopamine is associated with pleasure and reward systems but also plays a role in regulating energy expenditure and fat metabolism. Norepinephrine, closely related to adrenaline, is involved in the body's stress response and can stimulate fat breakdown and thermogenesis.The lecture then shifts to the metabolic effects of common mental health medications, such as SSRIs, tricyclic antidepressants, and antipsychotics. While these drugs can stabilize mood, they are often linked to significant metabolic disturbances, including weight gain, insulin resistance, and cravings for carbohydrate-heavy foods. Ben notes that these medications may exacerbate underlying metabolic issues, potentially worsening the mental health conditions they are meant to treat.Dr. Bikman concludes by emphasizing the importance of addressing metabolic health when treating mental health disorders. He highlights the role of brain glucose hypometabolism, where insulin resistance in the brain may contribute to anxiety and depression. He suggests that improving metabolic health through approaches like ketogenic diets could potentially enhance mental health outcomes by better nourishing the brain and restoring neurotransmitter balance.https://www.insuliniq.com Ben's favorite meal-replacement shake: https://gethlth.com (discount: BEN10)Ben's favorite electrolytes (and more): https://redmond.life (discount: BEN15)Ben's favorite allulose source: https://rxsugar.com (discount: BEN20)Ben's favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15)Ben's favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15)References:Due to character length constraints, references are not posted here. However, for a complete list, we respond quickly. Please email: support@insuliniq.com with your request, and be sure to mention which Metabolic Classroom episode you are referring to.#MentalHealth #MetabolicHealth #Antidepressants #AnxietyMedications #WeightGain #InsulinResistance #DrBenBikman #MentalHealthMedications #DepressionTreatment #MetabolismMatters #HealthAndWellness #Neurotransmitters #Type2Diabetes #BrainHealth #SSRIs #Antipsychotics #FatMetabolism #MentalWellness #HealthyLiving #NutritionAndMentalHealth Hosted on Acast. See acast.com/privacy for more information.

Yessss, it's FALL! That means it's time for Hallmark, Nora Ephron, and Nancy Meyers! Or if you're Beth, Norepinephrine. Please like, subscribe, share with a friend, and give us five stars!!!!Join Patreon for ad-free, and check out our instagram for our limited DON'T F*CK WITH MR ZERO shirt! Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Show notes at pharmacyjoe.com/episode958. In this episode, I'll discuss differences in heart rate in patients with sepsis and AFib between phenylephrine and norepineprhine. The post 958: Sepsis and AFib heart rate differences with phenylephrine vs norepinephrine appeared first on Pharmacy Joe.

Why are some of us anxious and some of us excited (or a combo platter of both)? And is it possible to turn anxiety, or anger, or shame spirals, into something else?  David and Isabelle swap stories, talk transgenerational trauma, and get curious about how we are socialized to mask and behave...and that perhaps the solution for being overly apologetic lies in the midwestern gem: "ope.”-----Isabelle starts by expanding on the idea of how you think about things, how that inner landscape can connect into tapping into norepinephrine—if you're practicing going “I see you anxiety, I see what you're trying to do, and I'm so grateful I have you because it helps me…” what it means to not shame or blame yourself for having an instinct to worry versus what you do know to be true. Short of someone giving you direct feedback, you don't have data either way, so saying hi to your anxiety or feeling, and taking a few breaths to be grateful. Then when you do have a tough moment, like a hard meeting at work, you won't beat yourself up about it as much. David even says: you can skip the shame spiral. Norepinephrine is so much about the inertia and movement of something. People with kids who have ADHD either have a very very clean room, or very very messy room. For those with a messy room, they're like “where to start? Do I burn it and start over again?” Then you give them one specific thing to do, they earn dopamine from that one thing. So you build momentum by building a feedback loop between dopamine and norepinephrine, because you judge yourself on a very reasonable scale. If you make a broad request, it's like “whaaa?” If you say “pick up your legos” or “Hunt for all the legos you can, you have 7 minutes, you earn 3 snarf points? What's a snarf point? I'll tell you in 7 minutes”—you now have specificity, and time pressure, and reward. Isabelle describes that she lives in the anxious side of the spectrum, and David lives in the excitement of it. If anxiety and excitement are the same physiological symptoms, how can you replace the two things? Isabelle wonders at her anxiety, which she is not bummed about, but knows that it's a part of her, and also knows that it has served her and her people across the generations—like she feels less anxious when she has a very stocked pantry or fridge. How can that be turned into excitement? We're talking about the interplay of epigenetics, and the interplay of how you lean into the anxiety. If you're in the United States, you'd be hard pressed to not have a transgenerational history of trauma, and as men and women (and non-binary folx), we are treated differently and are rewarded for going to anger or anxiety.  Men are traditionally reinforced for getting angry in the U.S.—it's reinforcing for them, and it's not great, and in the same way anxiety may be reinforced for women. Not that it's so cut and dry and binary-based. David elaborates that his impulsivity has been viewed as confidence, whereas for women, it can be viewed as overemotionality, and can be shamed, or put in corners. David had to work really hard to find excitement, he was way more in that angry place, fighting any system, any person he could. When you get angry, you feel yucky afterwards for like two hours, and he met really good friends, had an amazing brother, and had good supports, and a lot of people don't have that. And he had a choice in that moment whether to get anxious or excited. Isabelle is so grateful David shared that about himself and felt so seen, really resonating with the idea that whereas David's impulsivity was viewed as confidence, hers was read as overreacting, or overdramatic. She describes how she makes big gestures and shrieks and has big reactions to things and how often she has to blunt them or try to mask them in her daily life. She also recognizes the layers of privilege she carries as a white, cisgendered woman, that she has gotten a lot of reinforcement for her anxiety. Her asking, let's say, her kid's teacher a detail-oriented question seems almost assumed, that she would be the one who needs to be vigilant about the details of things, whereas her husband, Bobby, is seen as winning the day if he gets the kids to school, even though he is more effective at this. How we're socially viewed impacts how we think about it—perhaps Bobby running late is viewed as he was busy doing important things, whereas Isabelle names she has been conditioned to be extra apologetic and nervous and take it on as some awful thing that she's running late. David goes into Tavistock group dynamics stuff (see show notes below)—based around the work of Wilfred Bion—where people learn how they are in a group. David was in a group and someone came in late and were overly explaining it, the group ended up attacking her about all her apologies—David named there is an art to being late, and it is this: acknowledging the inconvenience, being very small, and apologizing at the end. Don't talk too much or give too many specifics, just say “my bad” and be quiet and wait to figure out what's happening. David and Isabelle both agree that they are habitually late, and hate being late, but will be late because of who they are. They just will be. Isabelle names an old meme: “Sorry I was late, it's because of who I am as a person.” She mentions connecting with her friends, one of whom says instead of saying “I'm so sorry” for being late, reserve sorries for deep relational healing moments where you feel harm was caused, intentionally or not. For example, being late, or accidentally bumping into someone, or dropping something off late—is not always the context for an “I'm sorry,” but instead, you could use the phrase “thank you for your patience.” David agrees, except for the bumping into someone else part—he has to say he's sorry. Isabelle thinks a simple midwestern “ope!” Will suffice, which David recently witnessed himself doing in the wild. Ope: (according to Urban Dictionary) - a midwestern U.S. way of acknowledging another person or thing they have encountered. Ope! Sorry I bumped into you, Jim. Ope, there's my wallet. Ope! I missed my bus! (added by us): Also known as an interjection of surprise and implied apology.DAVID'S DEFINITIONS Epigenetics - from CDC “Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence.” (source: CDC)Transgenerational trauma: from wikipedia“is the psychological and physiological effects that the trauma experienced by people has on subsequent generations in that group.” (source: Wikipedia) Imagine the collective trauma experienced by groups of people surviving slavery, wars, famine, natural disasters, etc. and the ways in which epigenetic (see definition above) may alter the way even our genes can express themselves and how we adapt and respond to stressors. For more on this, check out the pioneering work of Yehuda and Lehrner (Article on intergenerational transmission of trauma)Dopamine deficiency? ADHD is often understood as neurobiological (brain) difference, that includes lower levels of dopamine, the neurotransmitter (messenger chemical) in our br...

The PEC podcast team covers the Prehospital Emergency Care Journal Volume 28 Number 3...Kind of.  As the PEC Journal grows, the PEC podcast team is breaking up Volume 28 Number 3 to allow for more discussion.  In this episode we cover the Out of Hospital Cardiac Arrest section. We talk about engaging manuscripts in this journal like: COVID-19 Testing Among Out-of-Hospital Cardiac Arrest Patients: Implications for Public Health & Prehospital Administration of Norepinephrine and Epinephrine for Shock after Resuscitation from Cardiac Arrest Click here to download it today! As always THANK YOU for listening. Hawnwan Philip Moy MD (@pecpodcast) Scott Goldberg MD, MPH (@EMS_Boston) Jeremiah Escajeda MD, MPH (@jerescajeda) Joelle Donofrio-Odmann DO (@PEMems) Maia Dorsett MD PhD (@maiadorsett) Lekshmi Kumar MD, MPH(@Gradymed1) Greg Muller DO (@DrMuller_DO) Ariana Weber MD (@weberMD4) Rebecca Cash PhD (@CashRebeccaE) Michael Kim MD (@michaelkim_md) Rachel Stemerman PhD (@steminformatics) Nikolai Arendovich MD Elijah Robinson MD

TIME STAMPS: 02:00 REVIEW FROM LAST WEEK: Psalm 27:14 reads “WAIT for the LORD; be STRONG, and let your HEART be COURAGEOUS!” 03:50 THIS WEEK'S THEME: OPTIMIZING YOUR MORNING ROUTINE / Isaiah 51:9 reads “WAKE UP! WAKE UP! PUT ON THE STRENGTH OF THE LORD'S POWER!”  This verse is also a springboard into a big lesson that ISRAEL needed to hear shortly before their deportation to Babylon a little over 2000 years ago. 04:49 If you've been subscribed to EITHER OF OUR PODCASTS you probably know Marilu! THIS SHOW: E269 - BioHacking Brain & Gut Health, with Marilu Hayes OUR DEEP DIVE NUTRITION SHOW that I co-host with Coach Richard: 066: Norepinephrine, Dopamine, & Cortisol, with Behavior Scientist Marilu Hayes She's a BEHAVIORAL SCIENTIST, CONSULTANT, and ASPIRING NEUROPSYCHOLOGIST and you can also check out her recent interview on Carnivore Conversations with Dr. Robert Kiltz which was SPECTACULAR!!! Website www.mariluhayes.com / IG mariluluhayes 06:54 TODAY Isaiah's prophecy is EVEN MORE APPLICABLE to CHRISTIANS who interpret the Bible with a LITERAL HERMENEUTIC which is how I've been taught. 07:38 Does the Carnivore Diet cause SCURVY if you don't supplement vitamin C?! 10:21 Reading & discussion around Isaiah 51:1-17 NLT. 20:00 Discussion around our favorite Bible translations, resources & tools and what we recommend depending on your level of education & experience has been in your faith journey. 29:54 Reading & discussion around Revelation Chapter 3. 52:02 Quick summary of Colt's peak week coming into The Open Natural. 46:04 All about MORNING ROUTINES and how to do what you can if you're a busy mom or dad!!! MEAT & GREET BOOKING LINK: Select a Date & Time - Calendly   PURELY TALLOW ANIMAL BASED SKINCARE: Save 10% with code COLT10! 

This is the third and final episode of the series focused on basic anesthetic drugs. In this episode, we will explore vasopressors and inotropes.  After listening to this episode, you will be able to: 1. Outline the role of vasopressors 2. List the 5 main vasopressors used in the OR and their indications 3. Describe the mechanism of action for Phenylephrine, Ephedrine, Norepinephrine, Epinephrine, and Vasopressin  

TIME STAMPS: 02:04  Vitalijus Sivakovas - Lithuania - “Thank you both of you! So much good information and had a good laugh! Brilliant podcast.” 02:32 THIS WEEK'S L.I.S.S. - Danielle Fischer (WNBF PRO) Per her posing coach Laura Turtle she has a “noticeable increase in triceps mass since her last posing session 4 weeks ago” since we started focusing harder on her triceps! IG: @ danielleluvfischer01 04:38 MYTH: YOU CANNOT BUILD MUSCLE ON THE CARNIVORE DIET (wrong). 07:41 VEGETABLE OILS - the good, the bad, and the UGLY. Actually they're mostly bad but some of them aren't so bad like olive oil and avocado oil. 13:13 Recap of “The Great Olive Oil Debate!” 14:15 EMILY - HAIR LOSS QUESTION - Troubleshooting HAIR LOSS after prolonged periods of being in ketosis. 20:00 ANONYMOUS (“EDDIE”) - Recently got off anxiety medications and currently consuming a meat-based diet very similar if not more strict than myself. Has PTSD (ex-army) Dietary recommendations for some who has recently embarked on a journey to live life free of anxiety meds? 26:36 All about EGGS: How to identify how much nutrition is really in the yolk! 29:04 The difference between DISCIPLINE and MOTIVATION (they are not mutually exclusive).  32:02 NOREPINEPHRINE + DOPAMINE, and their harmonious role in AROUSAL, REACTION TIME and MEMORY FORMATION. 33:30 How to pay attention to what you can control when you are in a stressed state of mind. 35:17 Tips on getting into a creative place, also known as a state of “flow.” 38:01 Books, resources, and lessons around SUSTAINABLE GOAL SETTING. 45:54 Feeding your PET CATS like the miniature lions they are! 49:40 How to book a FREE DISCOVERY CALL with Coach Marilou! www.mariluhayes.com / IG mariluluhayes

Contributor: Travis Barlock MD Educational Pearls: Recent study assessed outcomes after ROSC with epinephrine vs. norepinephrine Observational multicenter study from 2011-2018 285 patients received epineprhine and 481 received norepinephrine Epinephrine was associated with an increase in all-cause mortality (primary outcome) Odds ratio 2.6; 95%CI 1.4-4.7; P = 0.002 Higher cardiovascular mortality (secondary outcome) Higher proportion of unfavorable neurological outcome (secondary outcome) Norepinephrine is the vasopressor of choice in post-cardiac arrest care References Bougouin W, Slimani K, Renaudier M, et al. Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock. Intensive Care Med. 2022;48(3):300-310. doi:10.1007/s00134-021-06608-7 Summarized by Jorge Chalit, OMSIII | Edited by Meg Joyce & Jorge Chalit  

In this episode, Rhea and Sachi discuss the most common vasopressors used in the OR, their indications, dose and mechanism of action. [FREE DOWNLOAD] FOR THE SRNA: GRAB YOUR FREE SEE/NCE STUDY PLAN HERE [FREE DOWNLOAD] FOR THE RN: GRAB YOUR FREE ICU DRUG CHART HEREFollow us on Instagram at: @Atomic_AnesthesiaCheck out our other free resources at AtomicAnesthesia.com

In this episode of the Saving Lives Podcast, we dive into a groundbreaking 2017 study comparing vasopressin and norepinephrine for treating vasoplegic shock after cardiac surgery. Discover the study's compelling results, how vasopressin outperformed norepinephrine in reducing severe complications, and the potential implications for clinical practice. The Vasopressor & Inotrope Handbook I have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy while supporting my endeavors. If you're in the US, you can order ⁠⁠⁠A SIGNED & PERSONALIZED COPY for $29.99⁠⁠⁠ or via ⁠⁠⁠AMAZON⁠⁠⁠ (for orders outside the US). Ebook versions: ⁠⁠⁠AMAZON KINDLE for $9.9⁠⁠⁠⁠⁠⁠9⁠⁠⁠. ⁠⁠⁠APPLE BOOKS⁠⁠⁠ and ⁠⁠⁠GOOGLE PLAY⁠⁠⁠.  ¡Excelentes noticias! Mi libro ha sido traducido al español y está disponible a traves de AMAZON. Las versiones electrónicas están disponibles para su compra for solo $9.99 en AMAZON KINDLE, APPLE BOOKS y GOOGLE PLAY. When you use these affiliate links, I earn an additional commission at no extra cost to you, which is a great way to support my work. Citation: Hajjar LA, Vincent JL, Barbosa Gomes Galas FR, Rhodes A, Landoni G, Osawa EA, Melo RR, Sundin MR, Grande SM, Gaiotto FA, Pomerantzeff PM, Dallan LO, Franco RA, Nakamura RE, Lisboa LA, de Almeida JP, Gerent AM, Souza DH, Gaiane MA, Fukushima JT, Park CL, Zambolim C, Rocha Ferreira GS, Strabelli TM, Fernandes FL, Camara L, Zeferino S, Santos VG, Piccioni MA, Jatene FB, Costa Auler JO Jr, Filho RK. Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial. Anesthesiology. 2017 Jan;126(1):85-93. doi: 10.1097/ALN.0000000000001434. PMID: 27841822. --- Support this podcast: https://podcasters.spotify.com/pod/show/eddyjoemd/support

In this episode of The Root Cause Medicine Podcast, Dr. Chip Watkins talks to us about neurotransmitters, what they are, what their functions are, the different types, and potential issues related to neurotransmitters. They dive into: 1. What is a neurotransmitter? 2. GABA deficiency symptoms 3. What are the main neurotransmitters? 4. How does the body make neurotransmitters? 5. Neurotransmitters and gut health Dr. Chip Watkins has over twenty years of experience in private practice, teaching, and corporate medicine. He uses mind-body medicine in his practice and nutritional approaches to care and has an understanding of traditional Chinese medicine, Ayurvedic medicine, and bioenergetics. Dr. Watkins is the President of NCHealthSPAN, Regional Medical Director at Community Care of NC, and Chief Medical Officer at Sanesco International. He is also a Member of the American Academy of Family Physicians and a past president and Chairman of the Board of the North Carolina Academy of Family Physicians.

Glutamate, GABA, Dopamine, Norepinephrine, Serotonin, and the whole HPA axis (stress response). These are some of the important systems in your brain that get messed up when you blast your brain with alcohol all the time. Then when we quit drinking, these get even more messed up. In this episode you'll learn what these 6 do, how alcohol messes them up, how they get more messed up when we quit drinking, and how long it takes for them to recover in sobriety. (TW: link between addiction and suicide when I discuss serotonin) What to listen to next E38: Central Nervous System Depression E75: How Sleep Improves from Actively Drinking to Long Term Sobriety E170: Here's Why The First Year of Sobriety is So Hard E201: Your Dysregulated Stress Response Sober Powered Skills Episode: Feel Calm, Boost Dopamine, Improve Your Mood, and Reduce Stress https://www.soberpowered.com/skills Sober Support: Community & Meetings: Living a Sober Powered Life https://www.soberpowered.com/membership Anger Management Program https://www.soberpowered.com/anger Sober Powered Skills (bonus episodes with practical application and coping skills) https://www.soberpowered.com/skills Weekly emails on Thursdays https://www.soberpowered.com/email Free resources https://www.soberpowered.com/free   Thank you for supporting this show by supporting my sponsors. Learn more: https://www.soberpowered.com/sponsors If you enjoyed this episode please consider buying me a coffee to support my work https://www.buymeacoffee.com/soberpowered Sources are posted on my website Disclaimer: all of the information described in this podcast is my interpretation of the research combined with my opinion. This is not medical advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Doug and Dennis discuss the appropriate use of vasopressors, specifically epinephrine and norepinephrine, in the management of shock. They highlight the importance of fluids in sepsis resuscitation and the potential dangers of using high concentrations of epinephrine. They also discuss the different effects of epinephrine and norepinephrine on heart rate and blood pressure, and the potential side effects of epinephrine, such as arrhythmias and lactic acidosis. The conversation concludes with a discussion on the use of epinephrine in anaphylaxis and the importance of individualizing treatment based on the patient's response. Takeaways Epinephrine is commonly used as a vasopressor in the management of shock, but it should be used with caution due to its potential side effects. Norepinephrine is often preferred over epinephrine in sepsis resuscitation due to its more selective vasoconstrictive effects and lower risk of arrhythmias. Fluid resuscitation is an important component of sepsis management and should be prioritized before initiating vasopressor therapy. Monitoring the patient's response to vasopressor therapy, including blood pressure, heart rate, and organ perfusion, is crucial in determining the effectiveness and safety of the treatment. Individualizing treatment based on the patient's specific needs and response is essential in optimizing outcomes in shock management. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠ or ⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

Ketogenic diets that are overdone may be hazardous according to new data, ultraviolet light exposure may boost metabolism, and muscle sport athletes have weird motivation. How can you pass all this up on your long holiday weekend?!  -------- Donate to the show: https://www.paypal.com/donate/?hosted_button_id=3J6ZFPPKG6E6N Subscribe at Apple iTunes: https://podcasts.apple.com/us/podcast/nutritionradio-org/id1688282387  Podcast on Spotify: https://open.spotify.com/show/1ECHrnjxjn33DBNWgErPtp Subscribe to our YouTube backup: https://www.youtube.com/lonman07?sub_confirmation=1 Podcast on Amazon/ Audible: https://www.audible.com/pd/NutritionRadioorg-Podcast/B0BS8LFLLX?qid=1675812257&sr=1-1&ref=a_search_c3_lProduct_1_1&pf_rd_p=83218cca-c308-412f-bfcf-90198b687a2f&pf_rd_r=YKEZ8DX192TQF0CQV8KX&pageLoadId=u3x6bJ1 Podcast network web site: https://sites.libsyn.com/455769/site

Curious about ADHD meds & not sure where to start? This episode covers:Understanding ADHD Medication: We explore what ADHD medication is and how it helps manage symptoms.Types of Medications: A look at stimulant and non-stimulant options and how they work.Addressing Fears: Discussing common concerns about addiction and side effects.Immediate Effects: How quickly can you notice changes, and what to expect.Personal Insights: I share my personal journey with ADHD medication, including challenges and positive changes.Advocacy and Choice: Encouraging you to advocate for yourself and discuss options with your doctor.Remember, the decision to use medication should be made with a healthcare provider. This episode aims to arm you with knowledge to make informed discussions about your health.Connect with Us:Are you a high-achieving woman with ADHD looking for a coach? Event planner looking for a wildly captivating speaker? Go to outsmartadhd.co to get in touch!

Hi and welcome back to The ADHD Skills Lab podcast! This is Producer Sarah speaking, thrilled to be bringing you this LIVE interview with Jamie Cutino, founder of Outsmart ADHD.Curious what Jamie has to share?Her origin story: ADHD diagnosis, loss of a parent, etc.HOT take: Impulsivity can be a strength for an entrepreneurNeuroscience & other research mentions: Dopamine, Norepinephrine, and Risk-Taking *BONUS: How do you think I (still Sarah) met Skye? Find me on IG and let me know!Thanks for being here! Until next time,~ Sarah R (Podcast Producer)ADHD Skills Discussed:Find creative outlets for impulsivity (for examples, listen to the episode!)The benefits of a "done list"Adding stimulation to mundane/repetitive tasksReferences:1. UO Article: Is ADHD Good for Entrepreneurship?2. Neurobiology of Attention Deficit Hyperactivity Disorder (ADHD): A brief reviewLooking for Jamie?IG @jamie_outsmartadhdFB: Women with ADHD - Support & Strategies - Outsmart ADHDhttps://outsmartadhd.co/Looking for more content? Want to get in touch?We would love to hear from you! Feel free to @ us and drop a line or two!IG: Skye @unconventionalorganisationIG: Sarah @theadhdskillslabpodcastYT: Unconventional Organisation ADHDBuild ADHD-friendly Flexible Routines You'll Love. We'll guide you through the system we've used to help 800+ academics, entrepreneurs, and working professionals with ADHD reach their goal within one month.https://www.unconventionalorganisation.com/the-adhd-academyClick here to learn more and looking forward to seeing you there!

Can MDMA make you a better person? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly learn about the neuroscience of empathy, psychopathy, and MDMA in the brain with neuroscientist Ben Rein, PhD. NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here:https://startalkmedia.com/show/the-science-of-mdma-with-ben-rein/Thanks to our Patrons Jason Hostens, John Lewis, Maria Dorman, Alejandro Reynoso, Radiel Cardentey, Amir Littman, Allan Rayer, Whitney, Tom Stidham, and Christopher Becks for supporting us this week.

Gina Poe has been working since 1995 on the mechanisms through which sleep serves memory consolidation and restructuring. Dr. Poe is a southern California native who graduated from Stanford University then worked for two post-baccalaureate years at the VA researching Air Force Test Pilots' brainwave signatures under high-G maneuvers. She then earned her PhD in Basic Sleep in the Neuroscience Interdepartmental Program at UCLA under the guidance of Ronald Harper then moved to the University of Arizona for her postdoctoral studies with Carol Barnes and Bruce McNaughtons looking at graceful degradation of hippocampal function in aged rats as well as hippocampal coding in a 3-D maze navigated in the 1998 space shuttle mission. She brought these multiunit teachings to answer a burning question of whether REM sleep were for remembering or forgetting and found that activity of neurons during REM sleep is consistent both with the consolidation of novel memories and the elimination of already consolidated memories from the hippocampus, readying the associative memory network for new learning the next day. Moving first to Washington State University then to the University of Michigan before joining UCLA in 2016, Poe has over 80 undergraduates, 6 graduate students, and 6 postdoctoral scholars, and has served in university faculty governance as well as leading 5 different programs designed to diversify the neuroscience workforce and increase representation of people of the global majority in the STEM fields. At UCLA she continues research and teaching and Directs the COMPASS-Life Sciences and BRI-SURE programs and co-Directs the MARC-U*STAR program. Nationally she is course director of the Marine Biological Lab's SPINES course and co-Directs the Society for Neuroscience's NSP program which earned the nation's highest mentoring honor in 2018. These programs have served over 600 PhD level trainees over the years.The Poe lab investigates the mechanisms by which sleep traits serve learning and memory consolidation. Memories are encoded by the pattern of synaptic connections between neurons. We employ tetrode recording and optogenetic techniques in learning animals to see how neural patterns underlying learning are reactivated during sleep, and how activity during sleep influences the neural memory code. Both strengthening and weakening of synapses is important to the process of sculpting a network when we make new memories and integrate them into old schema. Results from our studies suggest that while synaptic strengthening can be efficiently accomplished during the waking learning process, the synaptic weakening part of memory integration requires conditions unique to sleep. The absence of noradrenaline during sleep spindles and REM sleep as well as the low levels of serotonin during REM sleep allow the brain to integrate new memories and to refresh and renew old synapses so that we are ready to build new associations the next waking period. Memory difficulties involved in post-traumatic stress disorder, Schizophrenia, Alzheimer's disease and even autism involve abnormalities in the sleep-dependent memory consolidation process that my lab studies. Keywords: Sleep, learning and memory, PTSD, memory consolidation, reconsolidation, REM sleep, sleep spindles, Norepinephrine, LTP, depotentiation, reversal learning, optogenetics, electrophysiology, tetrode recordings, hippocampus, prefrontal cortex.Website: https://poe-sleeplab.weebly.com/

What goes on in your mind has a profound effect on your body. Thoughts and emotions affect all organs, including the immune, nervous, hormonal, circulatory, and reproductive systems. Emotional wellness is a vital part of your health & total wellness. When our emotions become excessive or repressed for a long time, they negatively impact the energy flow through our meridians. Your Heart and Your Emotions The heart pumps blood to nourish the cells but can get weakened due to anxiety and stress. Anxiety can affect the heart's normal functioning, raising your blood pressure and white blood cell count and increasing blood sugar through the action of adrenalin. Stress affects circulation, the heart, and the nervous system. In early Western medicine, doctors already believed emotions caused diseases. A powerful mind-body connection through which emotional, mental, social, spiritual, and behavioral factors can directly affect our health. Living with fear often leads to depression and negatively impacts health. Learning to unwind before bed and nourishing a grateful heart with optimistic thinking by writing in a gratitude journal is good for your health. Connecting Emotions and Wellness The connection between emotions and the human body has been a core topic throughout the history of science. Research indicates there are close relationships between emotions and bodily reactions during the formation of mental experiences. Physiological responses, such as cardiovascular, neuroendocrine, skeletomuscular, and autonomic nervous systems, trigger emotional experiences. Now, we understand that direct and instantaneous interactions within the body allow an emotion to be a mental recognition and a feeling within the body. The mind and body are within a unified framework. Different functions and components of the bodily system are related to corresponding categorical emotions. A 2017 research on “Understanding Mind-Body Interaction from the Perspective of East Asian Medicine” analyzed relationships between the visceral system and emotions according to the principles of East Asian medicine. The research concluded the following: -anger was related to the liver, -happiness to the heart, -thoughtfulness to the heart and spleen, -sadness to the heart and lungs, -fear to the kidneys, heart, liver, and gallbladder, -surprise to the heart and gallbladder, and -anxiety to the heart and the lungs. The research also demonstrated that specific patterns existed between the visceral system and corresponding emotions, which suggests that each emotion is primarily associated with a connected body system and corresponds to the principles of East Asian medicine. For example, the DongUiBoGam, the Korean book compiled by the royal physician Heo Jun and was first published in 1613, states the following: “The liver is in charge of anger, the heart is in charge of happiness, the spleen is in charge of thoughtfulness, the lungs are in charge of sadness, and the kidneys are in charge of fear.” Imbalances in emotions can lead to illnesses in their corresponding organs, such as -anger damages the liver, -happiness damages the heart, -thoughts damages the spleen, -anxiety damages the lungs, -fear damages the kidneys, and -surprise damages the gallbladder. The relationship between the mind and the body is horizontal, meaning the heart is significantly prevalent in most emotions. Experts consider the heart as common visceral system that influences emotions. The Korean book states the heart stores the mind, and feelings of sadness, thoughtfulness, and worries all damage the heart, signifying the heart's role in processing thoughts and emotions. Western medicine and East Asian medicine have different understanding of emotions and their relationship to the body, which leads to distinct interpretations of illness. Western medicine deals with emotional disorders using neural language, and East Asian medicine uses somatic language. Understanding this difference can offer a comprehensive perspective when healing the human body and its symptoms. Both viewpoints help us understand emotional health. The somatic language uses intuition to unlock your powers to soothe, calm, and heal. From the moment we're born, we instinctively seek ways to help and nourish our human condition. Neuroscience Lense on Emotions Neuroscience offers a look at how emotions impact the body. Neurophysiological factors play a vital role in the process of emotions. In 1985, neuroscientist Candace Pert discovered small proteins known as neuropeptides activate the circuits linked to emotions. Therefore, it's helpful to look at both Western and East Asian medicine approaches and to gain insight into how your body is functioning and take the guesswork out; getting tested with a non-invasive urine test to check over 70 markers, including your neurotransmitters, is essential. Why is it so essential to check neurotransmitters in balancing your emotions? First, conventional doctors never check your markers, so how will they offer the best solution for you? Do you know what your neurotransmitter levels are? Here are some of the important markers that we check with our specialized labs and why it is imperative to check the following markers: Norepinephrine marker: Responsible for the regulation of cardiovascular activity, body temperature, and pain sensation. Research has shown that there is a close link between this marker and anxiety and a relationship between depression and disturbance of norepinephrine in the brain. Serotonin marker: Found in the central nervous system, the gastrointestinal tract, and blood platelets influences biological and neurological processes, such as anxiety, aggression, appetite, sleep, mood, and thermoregulation. Dopamine marker: Responsible for emotion regulation is associated with mood, behavior, and cognition mediation. Recent studies in Western medicine suggest dysregulation of neurotransmitters could be one of the most important causes of emotional issues. Interest in the neuroscientific investigation has increased dramatically in the past few decades, and that's where functional medicine lab testing comes in to provide further insight into your total wellness. Integrating East & West would look into supporting organs while testing for your neurotransmitters and GI health levels with an organic acid test bundle. Support the liver function by balancing the HPA axis, spleen function by aiding the digestive system, and heart function with blood circulation and brain activity regulation. The mind-body connection is natural and scientifically proven, as your body responds to how you think, feel, and act. Your body reacts physically when stressed, anxious, or upset. You may develop high blood pressure or stomachache after a stressful event. Learn to listen to your body and keep a journal of your symptoms and feelings. Take a personal body scan to see if you can feel where your emotions impact your body. How Emotions Affect Your Body Every organ corresponds to a particular emotion. Every disease stems from an organ or meridian/energy channel imbalance. Anger weakens your Liver Grief weakens your Lungs Worry weakens your Stomach Stress weakens your Heart and Brain Fear weakens your Kidneys. Love brings peace and harmony, strengthening your mind and body. Gaining insight into your neurotransmitters brings awareness and understanding. Dive into the East Meets West Approach to Understanding Emotion Dysregulation when you gain insight into your neurotransmitter levels and get them balanced. Bypass the appointment and the drive and get the convenience of lab testing sent to your home. Gain access to a variety of cutting-edge lab tests to get a deep dive into your health.  Your healthcare practitioner should know about your emotional health Discuss with your practitioner if your feelings are causing your physical problems and ways to manage not only your physical symptoms but also your emotional ones. Achieving emotional wellness is possible and can allow you to live a physically rewarding life as well. Order your lab test directly from the lab, complete it at home, and return it to the lab. Once your results are in, we will schedule our session to review your results. You'll receive actionable next steps to eliminate guesswork and start feeling better fast. Check your overall health with an Organic acid test and if you want a deep dive into neurotransmitters then add in the Neurotransmitter test. 

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.https://www.nature.com/articles/s41398-023-02317-5https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/https://www.nature.com/articles/s41398-018-0155-1https://www.nature.com/articles/nature10360https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmedhttps://www.nature.com/articles/s41380-022-01506-w(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I(22:25) Wrap-up and understanding Autism, and Contact Info

Trial of the Week: SOAP II Special Guest: Jessica Casey, PharmD, BCPS, BCCP @jmc_cardspharmd   Jessica Casey joins to discuss the April Trial of the Week “Comparison of Dopamine and Norepinephrine in the Treatment of Shock,” the SOAP II study, published in NEJM in 2010. We set the scene by reviewing catecholamine vasopressor receptor physiology, guideline recommendations, and pre-SOAP II research. Then we do a deep dive into the SOAP II trial of the week. Did including all forms of shock help or hurt? How does the mortality in this study compare with others? Would this have been as positive of a study in 2024? What do the guidelines recommend now? Is dopamine dead? Will anyone take norepinephrine's throne? Jessica and I review trial fun facts, stand-out supplementary materials, and much, much more.   Reference list: https://pharmacytodose.files.wordpress.com/2024/04/soap-ii-trial-of-the-week-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Norepinephrine Position Paper and Sepsis Research Priorities Special Guests: Brittany Bissell Turpin, PharmD, PhD, FCCM, BCCCP @BissellBrittany Patrick Wieruszewski, PharmD, BCCCP @pwierusz Seth Bauer, PharmD, FCCM, FCCP, BCCCP @SethRBauer   07:30 – Norepinephrine position paper introduction 11:35 – When did we realize this and what are the implications? 36:00 – Key task force take-aways 51:00 – SSC Research Committee history 56:00 – Submitting and ranking research questions 27:00 – Top 5 clinical sepsis research priorities 62:00 – Basic science priorities   Reference List: https://pharmacytodose.files.wordpress.com/2024/04/norepi-position-paper-and-sepsis-research-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters.  Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition.  We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health.  From increased breakdown linked to mood disorders to decreased activity associated with elevated neurotransmitter levels, we unravel the complex interplay between genes and mental well-being. - Check out SelfDecode: https://selfdecode.com/ - Join Joe's online community: https://thejoecohenshow.com/ 

FREE! CRNA School Interview Prep Guide: https://www.cspaedu.com/uc9a5ih4

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠from the Psychiatry section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

CHEST February 2024, Volume 165, Issue 2 Jason R. Yerke, PharmD, and Eduardo Mireles-Cabodevila, MD, join CHEST Podcast Moderator, Alice Gallo de Moraes, MD, FCCP to discuss peripheral administration of norepinephrine. DOI: https://doi.org/10.1016/j.chest.2023.08.019   Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.

Take Home Points: Know clinical (cold extremities, oliguria, confusion, dizziness, narrow pulse pressure) and laboratory markers (metabolic acidosis, elevated creatinine, lactic acidosis) of hypoperfusion. An elevated lactate is a danger sign and requires explanation. Norepinephrine is a great first line vasopressor in Cardiogenic shock. Dobutamine is useful for inotropic support in Cardiogenic shock. Use POCUS ... Read more The post REBEL Core Cast 115.0 – Cardiogenic Shock appeared first on REBEL EM - Emergency Medicine Blog.

We recently made a significant vasopressor protocol change at MCHD, prioritizing norepinephrine in all shock situations except anaphylaxis and bradycardia. The evidence supporting norepinephrine in septic and even cariogenic shock is relatively solid. However, recent data has emerged suggesting norepinephrine may be safer in post-ROSC shock as well. REFERENCES 1. Bougouin W, Slimani K, Renaudier M, et al; Sudden Death Expertise Center Investigators. Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock. Intensive Care Med. 2022 Mar;48(3):300-310. 2. Wender ER, Counts CR, Van Dyke M, et al. Prehospital Administration of Norepinephrine and Epinephrine for Shock after Resuscitation from Cardiac Arrest. Prehosp Emerg Care. 2023 Sep 14:1-6.

Dr. Todd Cameron joins us again on Vitality Radio, this time to discuss a hot topic you've likely heard something about - Adrenal Fatigue. Jared and Dr. Cameron discuss what this term really means, how prevalent it is, what causes it, and what we can all do to work through it and prevent it. You'll learn about the phases of adrenal fatigue, natural cortisol patterns, and why it's so vitally important that we manage our stress response.Products:Precision Probiotic Vital SporesVital 5 Magnesium BisglycinateVital 5 Omega 3 + AntioxidantsUltra Strength RX Omega 3Sensoril AshwagandhaAnxiety ReleaseVital SleepL-Theanine chewables Redmond Real SaltAdditional Information:Cameron Wellness + Spa 801-486-42263378 South 2300 East, Salt Lake City, UTEpisode #327: The Natural Approach to Mental Health: How To Optimize Mood and Reduce Anxiety With Lifestyle and SupplementsEpisode #347: Thyroid Health: Why Your Doctor Might Be Looking at the Wrong Numbers With Dr. Todd CameronEpisode #331: The Functional Medicine Approach to Testosterone for Men and Women with Dr. Todd Cameron NMDVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Show notes at pharmacyjoe.com/episode855. In this episode, I’ll discuss the effect of phenylephrine push prior to continuous infusion norepinephrine in patients with septic shock. The post 855: Effect of phenylephrine push prior to continuous infusion norepinephrine in patients with septic shock appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode855. In this episode, I’ll discuss the effect of phenylephrine push prior to continuous infusion norepinephrine in patients with septic shock. The post 855: Effect of phenylephrine push prior to continuous infusion norepinephrine in patients with septic shock appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode848. In this episode, I’ll discuss the treatment of norepinephrine extravasation. The post 848: Treatment of norepinephrine extravasation appeared first on Pharmacy Joe.

Hi! I've been in the hospital with pneumonia! But enjoy this banger of an encore about: Serotonin! Dopamine! Norepinephrine! Neurotransmitters: what's their deal? Dr. Crystal Dilworth, aka Dr. Brain, stops by to have a spirited discussion about how chemical messengers change our moods and behaviors. We chat about depression, anxiety, what chemicals drive us to get off the couch, how antidepressants work, ADHD, addiction, the microbiome, new habits, quitting smoking, starting meditation, Oreos vs. cocaine, SSRIs vs. SNRIs, what it's like to hold a human brain in your hands and if she would donate hers to science. Also: what's up with "lizard brains?"Visit Dr. Dilworth's websiteFollow Dr. Dilworth on Instagram & TwitterA donation went to The Geena Davis Institute: seejane.orgMore episode sources and linksSmologies (short, classroom-safe) episodesOther episodes you may enjoy: Attention-Deficit Neuropsychology (ADHD) Part 1 with Dr. Russell Barkley, Attention-Deficit Neuropsychology (ADHD) Part 2, LIFE ADVICE: For anyone who needs some hacks, Dolorology (PAIN), Eudemonology (HAPPINESS), Chronobiology (CIRCADIAN RHYTHMS) Encore + 2023 Updates, FIELD TRIP: An Airport Full of Neuroscientists, Oneirology (DREAMS), Thanatology - NEW Interview (DEATH, GRIEF & MOURNING), Neuropathology (CONCUSSIONS), Molecular Biology (PROTEINS + SCIENCE COMMUNICATION), Awesomeology (GRATITUDE FOR LITTLE THINGS), Oikology (DECLUTTERING), Philematology (KISSING), Traumatology (PTSD), Victimology (CRIME VICTIMS), Personality Psychology (PERSONALITIES), Somnology (SLEEP),  Fearology (FEAR) Pt. 1, Fearology (FEAR) Pt. 2, Sports & Performance Psychology (ANXIETY & CONFIDENCE)Sponsors of OlogiesTranscripts and bleeped episodesBecome a patron of Ologies for as little as a buck a monthOlogiesMerch.com has hats, shirts, masks, totes!Follow @Ologies on Twitter and InstagramFollow @AlieWard on Twitter and InstagramEditing by Mercedes Maitland of Maitland Audio Productions, Jarrett Sleeper of MindJam Media, and Steven Ray Morris Transcripts by Emily White of The WordaryWebsite by Kelly R. DwyerTheme song by Nick Thorburn

In this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://www.livemomentous.com/huberman The Brain Body Contract https://hubermanlab.com/tour Timestamps (00:00:00) Stimulants & Attention-Deficient/Hyperactivity Disorder (ADHD) (00:03:21) Sponsors: Maui Nui, ROKA, HVMN (00:06:35) The Brain-Body Contract (00:07:22) Attention, Prefrontal Cortex & ADHD (00:16:27) Stimulants “Sympathomimetics” (00:21:29) Adderall, Dopamine & Norepinephrine (00:25:58) Sympathomimetics, Dopamine & Norepinephrine (00:31:05) Sponsor: AG1 (00:32:20) Vyvanse is Timed-Release D-Amp (00:36:36) Ritalin, Concerta (00:40:10) Dopamine & “Noise Reduction”; Norepinephrine & “Signal Amplification” (00:45:28) ADHD: Focus, Hyperactivity & Impulsivity; Drug Selection & Dose (00:50:57) How do Stimulants ‘Calm' ADHD? (00:54:480 Neuroplasticity & Neuromodulators (00:58:06) Kids, ADHD Diagnosis & Treatment; Predispose Addiction? (01:04:02) Sponsor: InsideTracker (01:05:12) ADHD Medications: Individuality, Doses, Tapering & Long-Term Use (01:13:28) Medication & Long-Term Effects: Height, Cardiovascular Risk, Alcohol (01:19:32) Cortisol & Hormones (01:27:45) Psychosis & Addiction; Methamphetamine (01:38:20) Recreational Use, Addiction & Psychosis; Habituation (01:42:30) Drug Holidays; Ritalin & Long-Term Effects (01:45:35) Modafinil, Armodafinil; Side-Effects (01:53:03) Guanfacine, Alcohol (01:58:03) ADHD Medications (02:00:26) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer