Podcasts about retrotransposons

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in cave nectar bats (Cell Rep) Cave nectar bat colony (J Am Asso Lab An Sci) Retrotransposons activate erythropoiesis (Science) TLRs and ERVs (Immunity) Letters read on Immune 88 Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.04.531072v1?rss=1 Authors: Garza, R., Atacho, D., Adami, A., Gerdes, P., Vinod, M., Hsieh, P., Karlsson, O., Horvath, V., Johansson, P. A., Pandiloski, N., Matas, J., Quaegebeur, A., Kouli, A., Sharma, Y., Jonsson, M. E., Monni, E., Englund, E., Eichler, E. E., Gale Hammell, M., Barker, R. A., Kokaia, Z., Douse, C. H., Jakobsson, J. Abstract: The genetic mechanisms underlying the expansion in size and complexity of the human brain remains poorly understood. L1 retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution is largely unknown. Using multi-omic profiling we here demonstrate that L1-promoters are dynamically active in the developing and adult human brain. L1s generate hundreds of developmentally regulated and cell-type specific transcripts, many which are co-opted as chimeric transcripts or regulatory RNAs. One L1-derived lncRNA, LINC01876, is a human-specific transcript expressed exclusively during brain development. CRISPRi-silencing of LINC01876 results in reduced size of cerebral organoids and premature differentiation of neural progenitors, implicating L1s in human-specific developmental processes. In summary, our results demonstrate that L1-derived transcripts provide a previously undescribed layer of primate- and human-specific transcriptome complexity that contributes to the functional diversification of the human brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.246769v1?rss=1 Authors: Ipsaro, J. J., O'Brien, P. A., Bhattacharya, S., Palmer, A. G., Joshua-Tor, L. Abstract: The piRNA pathway safeguards genomic integrity by silencing transposable elements in the germline. While Piwi is the central piRNA factor, others including Asterix/Gtsf1 have also been demonstrated to be critical for effective silencing. Here, using eCLIP with a custom informatic pipeline, we show that Asterix/Gtsf1 specifically binds tRNAs in cellular contexts. We determined the structure of mouse Gtsf1 by NMR spectroscopy and identified the RNA binding interface on the protein's first zinc finger, which was corroborated by biochemical analysis as well as cryo-EM structures of Gtsf1 in complex with co-purifying tRNA. We further show that LTR retrotransposons are preferentially de-repressed in Asterix mutants. Given the role of tRNAs as LTR retrotransposon primers, our work implicates Asterix/Gtsf1 as exploiting tRNA dependence to identify transposon transcripts and promote piRNA silencing. Copy rights belong to original authors. Visit the link for more info

Hosts: Ed Brown, Dr. Shayne Joseph, Lucas Randall 00:01:31 While studying the enzyme produced by a bacteria that eats plastic, an international team has accidentally made it even better. 00:08:57 NASA's new planet-hunding spacecraft has launched. TESS will study 85% of the sky, and will be able to study the mass, size, density and orbit of thousands of exoplanets. 00:23:37 Retrotransposons - elements of DNA that can spread to other species - are being found more and more often. And they're almost ubiquitous in marine animals, especially shellfish.   This episode contains traces of French President Emmanuel Macron speaking before the US Congress.

Investigadores en el Programa de Células Madre en UC San Diego han utilizado un raro desorden, Aicardi Goutieres (AGS), para explorar mecanismos fundamentales del cerebro. Utilizando organoides corticales, o cerebros en una placa, han seguido el neurodesarrollo a medida que encontraban nueva información sobre la relación entre los retrotransposones y la neuroinflamación. Series: "El Canal de Células Madre" [Health and Medicine] [Spanish Language] [Show ID: 32917]

Pesquisadores do programa de células-tronco da Universidade da Califórnia em San Diego usaram uma doença rara, a Síndrome de Aicardi Goutieres (AGS), para investigar os mecanismos fundamentais do cérebro. Usando organóides corticais, ou cérebros, em um disco, eles monitoraram o neurodesenvolvimento enquanto descobriram novas informações sobre a correlação entre retrotransposão e neuroinflamação. Series: "O Canal de Células-Tronco" [Health and Medicine] [Spanish Language] [Show ID: 32916]

Investigadores en el Programa de Células Madre en UC San Diego han utilizado un raro desorden, Aicardi Goutieres (AGS), para explorar mecanismos fundamentales del cerebro. Utilizando organoides corticales, o cerebros en una placa, han seguido el neurodesarrollo a medida que encontraban nueva información sobre la relación entre los retrotransposones y la neuroinflamación. Series: "El Canal de Células Madre" [Health and Medicine] [Spanish Language] [Show ID: 32917]

Pesquisadores do programa de células-tronco da Universidade da Califórnia em San Diego usaram uma doença rara, a Síndrome de Aicardi Goutieres (AGS), para investigar os mecanismos fundamentais do cérebro. Usando organóides corticais, ou cérebros, em um disco, eles monitoraram o neurodesenvolvimento enquanto descobriram novas informações sobre a correlação entre retrotransposão e neuroinflamação. Series: "O Canal de Células-Tronco" [Health and Medicine] [Spanish Language] [Show ID: 32916]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms. By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation. Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms. By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation. Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms. By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation. Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms. By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation. Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]

Bartholomew Cubbins on RNA Episode 8: Current Papers - RNA Binding Sites, P-Bodies, and Retrotransposons Watch the video (pop) A rough look at the following papers:Virus-like particles of the Ty3 retrotransposon assemble in association with P-body components.andIntronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing.Kudos to PLoS and the Open Access option that allows the public real-time access of this great science.