Podcasts about L1

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Best podcasts about L1

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Latest podcast episodes about L1

Thinking Crypto Interviews & News

Crypto News: Ripple drops appeal in SEC XRP case as Judge Torres pushes back on both parties. President Trump makes bullish statements about Bitcoin and Crypto. Dana White says he is all in on VeChain.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Thinking Crypto Interviews & News
The Crypto Market Structure Bill Won't Pass in 2025! Here's Why! with Kristin Smith

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 27, 2025 44:44


Kristin Smith, President at Solana Policy Institute, joined me to discuss the current state of Crypto & Stablecoin legislation in the US.Topics:- Solana Policy Institute Overview - Stablecoin bill passing in the Senate- Crypto market structure bill may not pass in 2025 - SEC's new approach to Crypto- Howey Test and Crypto- The continued crypto advocacy in DCShow Sponsor -

Thinking Crypto Interviews & News
MASSIVE! US GOVERNMENT WILL ISSUE MORTGAGES WITH CRYPTO!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 26, 2025 17:36


Crypto News: The US Government Fannie Mae and Freddie Mac to prepare their businesses to count cryptocurrency as an asset for a mortgage. Robinhood CEO Vlad Tenev says crypto will replace traditional finance.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Thinking Crypto Interviews & News
Why VivoPower Chose XRP for its Treasury Strategy!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 26, 2025 42:07


Kevin Chin, CEO of VivoPower, and Adam Traidman, Chairman of the Board of Advisors for VivoPower, joined me to discuss VivoPower's XRP Treasury Strategy.Topics: - VivoPower(VVPR) Overview - Why XRP was chosen as a Treasury Asset - Building a DeFi ecosystem with XRP and Flare - Using BitGo for custody - Future of Crypto Treasury Strategy - Risks with market downsides - Holding and using the RLUSD stablecoin Show Sponsor -

Fantasy Football Scout
EFL FIXTURES RELEASED: INSTANT REACTION!

Fantasy Football Scout

Play Episode Listen Later Jun 26, 2025 57:00


In this episode, Scott & Chris react to the EFL fixture launch, looking at the best picks from GW1 for L1 & L2 and the Championship fixtures from GW2!

Radio foot internationale
Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi !

Radio foot internationale

Play Episode Listen Later Jun 26, 2025 48:28


Au programme de ce jeudi 26 juin dans Radio Foot à 16h10 TU & 21h10 TU : - Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi ! ; - Algérie – Romain Folz, stratège discret et sauveur d'Akbou.   Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi ! L'Inter Milan s'impose face à River Plate (2‑0) au terme d'un match tendu, marqué par deux cartons rouges côté argentin. Pendant ce temps, les Mamelodi Sundowns concédaient un nul face à Fluminense, qui retrouvera les Nerazzurri en huitièmes. Résultat : aucun club africain en huitièmes, un constat amer. Pourquoi l'Afrique manque-t-elle les huitièmes ? Transfert : Moses Simon débarque au Paris FC ! À 29 ans, l'international nigérian quitte Nantes pour signer au Paris FC, promu en Ligue 1, pour 7 M€, avec un contrat de trois ans. Rapide, expérimenté, combatif : un gros coup pour le club de la capitale. Simon symbolise-t-il la politique de recrutement du club en L1 ?   Algérie – Romain Folz, stratège discret et sauveur d'Akbou Il a quitté les Sundowns en février, a pris les rênes de l'Olympique d'Akbou dans l'anonymat… et a réussi sa mission maintien. En Ligue 1 algérienne, Romain Folz a transformé le club dans l'ombre, loin des projecteurs. L'entraîneur français est notre invité du jour. Retour sur un sauvetage express et maîtrisé.   Présentation : Annie Gasnier | Édition : David Fintzel | TCR : Laurent Salerno | Consultants : Marina Lorenzo, Nabil Djellit, Bruno Constant.

Radio Foot Internationale
Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi !

Radio Foot Internationale

Play Episode Listen Later Jun 26, 2025 48:28


Au programme de ce jeudi 26 juin dans Radio Foot à 16h10 TU & 21h10 TU : - Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi ! ; - Algérie – Romain Folz, stratège discret et sauveur d'Akbou.   Mondial des clubs : l'Inter punit River, l'Afrique éjectée du tournoi ! L'Inter Milan s'impose face à River Plate (2‑0) au terme d'un match tendu, marqué par deux cartons rouges côté argentin. Pendant ce temps, les Mamelodi Sundowns concédaient un nul face à Fluminense, qui retrouvera les Nerazzurri en huitièmes. Résultat : aucun club africain en huitièmes, un constat amer. Pourquoi l'Afrique manque-t-elle les huitièmes ? Transfert : Moses Simon débarque au Paris FC ! À 29 ans, l'international nigérian quitte Nantes pour signer au Paris FC, promu en Ligue 1, pour 7 M€, avec un contrat de trois ans. Rapide, expérimenté, combatif : un gros coup pour le club de la capitale. Simon symbolise-t-il la politique de recrutement du club en L1 ?   Algérie – Romain Folz, stratège discret et sauveur d'Akbou Il a quitté les Sundowns en février, a pris les rênes de l'Olympique d'Akbou dans l'anonymat… et a réussi sa mission maintien. En Ligue 1 algérienne, Romain Folz a transformé le club dans l'ombre, loin des projecteurs. L'entraîneur français est notre invité du jour. Retour sur un sauvetage express et maîtrisé.   Présentation : Annie Gasnier | Édition : David Fintzel | TCR : Laurent Salerno | Consultants : Marina Lorenzo, Nabil Djellit, Bruno Constant.

Thinking Crypto Interviews & News
Buying Millions in Solana for a Treasury Reserve Strategy | DeFi Development Corp

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 25, 2025 42:54


Joseph Onorati, CEO of the Defi Development Corporation, joined me to discuss the company's Solana treasury strategy.Topics: - DeFi Development Corp overview - Choosing Solana as a treasury reserve asset - Cantor Fitzgerald coverage of Solana treasury companies - Trend of companies using Crypto as a treasury reserve asset - Risks that come with a bear marketShow Sponsor -

Thinking Crypto Interviews & News
Fed Jerome Powell Gives Banks Ability To Pump Crypto!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 25, 2025 23:25


Crypto News: Federal Reserve Chair Jerome Powell says "banks are free to conduct crypto activities.".Anthony Pompliano's ProCap buys 3,724 Bitcoin. Bill Pulte says US government will into crypto being used for mortgages.Show Sponsor -

Thinking Crypto Interviews & News
Nba Champion Tristan Thompson on How Crypto & AI Will Revolutionize Sports!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 24, 2025 47:39


Tristan Thompson, Chief Content Officer of TracyAI, joined me to discuss how crypto and AI will impact sports—and how his new AI solution aims to revolutionize basketball analysis. https://tracy.tech/Topics:- Can NBA Contracts include Bitcoin? - Players tokenizing themselves and contracts- Future of Crypto and Web3- TracyAI Overview - Cavs Season Outlook - NBA Finals and how the game has changed-2016 Cavs 3-1 Comeback Show Sponsor -

Thinking Crypto Interviews & News
CRYPTO RALLIES AS BITCOIN REVERSES! $1 BILLION BITCOIN TREASURY SPAC!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 24, 2025 17:55


Crypto News: Bitcoin reverses and price moves over $105,000 again, is the bottom in? Anthony Pompliano is doing a $1 billion BitcoinTreasury Company SPAC. The Federal reserve is easing crypto banking restrictions. Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/

Thinking Crypto Interviews & News
IS IT OVER FOR BITCOIN & ALTCOINS AS WAR CRASHES CRYPTO?

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 23, 2025 13:46


The Defiant
Emin Gün Sirer on Scaling Avalanche and Redefining Decentralization

The Defiant

Play Episode Listen Later Jun 23, 2025 67:23


What does the future of blockchain look like, and where do multi-chain systems fit in? On this episode, we're joined by Emin Gün Sirer, CEO and Founder of Ava Labs and one of the most prominent figures in blockchain innovation. Emin unpacks how Avalanche is reshaping the decentralized world with its groundbreaking consensus protocol, multi-chain scaling, and commitment to maintaining blockchain's core values. We also discuss:Avalanche vs. Bitcoin and EthereumGaming and DeFi innovations on Avalanche Fighting centralization and the challenges of scale The role of stablecoins and central banks in Avalanche's ecosystem Chapters:00:00 Defiant intro00:07 If the future of blockchain is centralized, I don't want to be here00:54 intro to Emin Gün Sirer, Founder and CEO of Ava Labs04:29 Building the fastest consensus protocol on the market04:43 How is Avalanche different from Bitcoin?08:10 Avalanche vs. other multi chain systems 12:16 L2 scaling vs. multi chain scaling16:55 Evaluating Ethereum's promises 19:45 Interoperability on Avalanche20:25 What's the narrative behind Avalanche?23:47 Avalanche's long term strategy

Thinking Crypto Interviews & News
Coinbase Deribit Acquisition! The Largest in Crypto! with Aklil Ibssa

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 22, 2025 8:41


I interviewed Aklil Ibssa, Head of Corporate Development and M&A at Coinbase, at the Coinbase State of Crypto Summit. We discussed Coinbase's acquisition of Deribit — the largest in the crypto industry to date.

Thinking Crypto Interviews & News
SEC APPROVAL OF XRP & SOLANA ETFS CHANCES SURGE TO 90%!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 21, 2025 15:11


Crypto News: Bloomberg ETF analyst raise XRP and Solana ETF approvals to 90%. Depository Trust & Clearing Corporation(DTCC) met with SEC Crypto Task Force today to discuss tokenization. Show Sponsor -

Thinking Crypto Interviews & News
Anthony Scaramucci Talks Crypto, Stablecoins, Circle IPO, & Trump!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 21, 2025 11:23


I interviewed Anthony Scaramucci at the Coinbase State of Crypto Summit. We discussed crypto's continued growth, Donald Trump's crypto ventures, the Circle IPO, the stablecoin market, crypto regulation, and much more.

Thinking Crypto Interviews & News
Coinbase's Crypto Loans! Borrow Bitcoin for USDC! with Max Branzburg

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 20, 2025 10:48


I interviewed Max Branzburg, VP of Product at Coinbase, at the Coinbase State of Crypto Summit. We discussed Coinbase's crypto-backed loans, which allow users to borrow against their Bitcoin and receive the loan in USDC.

Thinking Crypto Interviews & News
TRUMP REDUCING HOLDINGS IN WORLD LIBERTY FINANCIAL! WHAT IT MEANS FOR CRYPTO!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 20, 2025 13:19


Crypto News: Trump family's company cuts stake in World Liberty Financial by 20%. Blockchain can solve world's largest data breach affecting Apple, Google, Facebook and more. Circle Rockets After Stablecoin Bill Clears Senate.Show Sponsor -

Thinking Crypto Interviews & News
Crypto Regulation News! Stablecoin Bill Passed in Senate & Moves to House! Market Structure Bill

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 19, 2025 25:38


Cody Carbone, CEO of The Digital Chamber, joined me to discuss the state of the Stablecoin and Crypto Market structure bills as they make their way through the legislative process.Topics:- Stablecoin Bill passes in the Senate, How fast can it pass in the House? - State of the Crypto Market Structure Bills - Is the Crypto Industry reviewing the Bills - Will Tether be affected by the US Stablecoin Legislation - SEC's new approach to Crypto - Upcoming Crypto Hearings Show Sponsor -

Thinking Crypto Interviews & News
Why BlackRock and Other Institutions Are Choosing Coinbase for Crypto!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 19, 2025 15:15


I interviewed Brett Tejpaul, Head of Coinbase Institutional, at the Coinbase State of Crypto Summit. We discussed the rising institutional demand for crypto and Coinbase's suite of institutional services.

Thinking Crypto Interviews & News
HUGE XRP NEWS! COINBASE XRP DEFI & ETF GOES LIVE! TRUMP READY TO SIGN CRYPTO & STABLECOIN BILLS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 19, 2025 12:21


Crypto News: XRP ETF goes live on Toronto Stock Exchange. Coinbase adds XRP DeFi via Base and Moonwell. Trump posts about stablecoin bill passing in Senate and that he is ready to sign. Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/

Thinking Crypto Interviews & News
The Future of Crypto Regulation with Coinbase's Top Lawyer Paul Grewal

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 18, 2025 8:09


I interviewed Paul Grewal, Chief Legal Officer at Coinbase, at the Coinbase State of Crypto Summit. We discussed the shifting approach to crypto by the SEC and the U.S. government, Coinbase's ongoing fight for regulatory clarity, and much more.

Thinking Crypto Interviews & News
HISTORIC! SENATE PASSES STABLECOIN LEGISLATION BILL! JPMORGAN LAUNCHES TOKEN ON COINBASE'S BASE!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 18, 2025 17:10


Unchained
Arthur Hayes and Hanson Birringer on Hyperliquid's Success (And What Could Stop It) - Ep. 852

Unchained

Play Episode Listen Later Jun 17, 2025 80:38


Hyperliquid is one of the most talked-about platforms in crypto right now. It's an onchain perpetuals exchange that sidestepped VCs, built a deeply loyal user base, and launched with transparency most rivals avoid. But it's also staring down some massive challenges—from incoming competitors like Coinbase and Robinhood, to the technical hurdles of decentralizing its core exchange engine. Arthur Hayes, CIO of Maelstrom and one of crypto's most iconic traders, and Hanson Birringer of Flowdesk discuss: What actually drove Hyperliquid's success How a user-first approach is outpacing venture-backed models Whether the James Wynn saga was legit Why the HIP-3 proposal could be the “holy grail” for DEXes And whether Hyperliquid can survive its next big test: the entrance of giants Visit our website for breaking news, analysis, op-eds, articles to learn about crypto, and much more: unchainedcrypto.com Thank you to our sponsors! Xapo Bank Bitwise Guests: Arthur Hayes, CIO of Maelstrom Hanson Birringer, Head of US Sales at Flowdesk Links Stats: CoinGlass: Total BTC Futures Open Interest Hyperliquid Stats James Wynn Unchained: Hyperliquid Trader Makes $87M in 70 Days, Loses It In Five James Wynn's address  Transparency Hyperliquid's founder's post on X saying that he felt like transparency results in better execution for whales compared to on private venues. Hyperliquid vs Binance: Unchained: Hyperliquid Saved Itself a $15 Million Loss, but Sparked Criticism Arthur Hayes' tweet on whether $HYPE perp volumes will flip Binance's this cycle. CZ's tweet on dark pool DEXs Cointelegraph: Binance co-founder CZ proposes dark pool DEXs to tackle manipulation Tokenomics: DL News: Hyperliquid's token buyback machine just hit $1b — is it sustainable? HIP-3: Hyperliquid Docs: HIP-3: Builder-Deployed Perpetuals Timestamps:

Thinking Crypto Interviews & News
Base and Coinbase Wallet Secrets Revealed! | Jesse Pollak

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 17, 2025 12:07


Thinking Crypto Interviews & News
JPMORGAN'S BIG CRYPTO MOVE REVEALED! XRP ETF GOES LIVE THIS WEEK! TRUMP BTC & ETH ETF

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 17, 2025 17:00


Thinking Crypto Interviews & News
Web3 Will Revolutionize Media & the Creator Economy | Aptos Ash Pampati

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 17, 2025 48:47


Ash Pampati, Head of Ecosystem at the Aptos Foundation, joined me to discuss the future of Web3 and Aptos' role in shaping it.Topics:- How platforms such as YouTube and Spotify will embrace Web3 - Creator Economy and Web3 - What makes Aptos different from other Blockchains - $200 Million DeFi grants - Rhuna, an AI-driven white-label event infrastructure platform, partnership - US Crypto Legislation Outlook Show Sponsor -

Rooster and the Devil
Interview Series: Bill Taylor of Boise Pro Soccer (USL League One and USL Super League)

Rooster and the Devil

Play Episode Listen Later Jun 17, 2025 29:21


USL League One spreading out West is an essential part of the plan over the next few years (“Manifest Destiny for L1”). Forming a Western Division would cut down on travel costs and make a 3rd tier professional club more affordable to operate. It is cities like Boise that are the perfect fit for joining the USL Western Front. The intrigue for the city as a potential soccer hotbed piqued after two friendlies produced sell-out results in the recent history. There was an Athletic Bilbao vs Liga MX Club Tijuana in 2015 that drew nearly 22k people into Boise State (where the infamous blue turf was covered with grass for the event…). Then there was a very unique event - where a USL Championship regular season league game took place (Portland Timbers II vs Swope Park Rangers) in 2016 at a High School in Boise and sold out the field at 4,350 people. The feeling of it being a good fit for USL is proving to be true as the club have already sold 3,500 season tickets for their USL League One Inaugural year. That is even without the branding in place (which is set to be released on June 27th). There was a brief period where the local Minor League Ownership group (of Boise Hawks) was speaking with USL to get a USL Championship squad. But Covid changed the narrative there. Now the timing is right and an All Star Front Office composed of four individuals - each with a different, unique specialty, are the ones backing this new project. There's NBA Executive experience, US Soccer Experience, Idaho Youth Soccer, and Real Estate Development experience all coming together to give this project legs. The Stadium project is perhaps one of the best stadium projects in the Country at the moment as well. They are converting an old horse racing track into a 6,000 fan soccer-specific stadium that has an incredible mountain backdrop. Phase 2 of the stadium project, which will hopefully be necessary as USL institutes promotion/relegation, would add an additional 5,000 seats for a capacity of 11,000 people. Needless to say, I'm looking forward to watching how things unfold in Boise, Idaho and I appreciate Bill Taylor for taking the time to speak with me. Here's a snippet of our conversation. If you want the full videos, visit our YouTube channel here.

Thinking Crypto Interviews & News
WILL WAR END THE CRYPTO BULL MARKET?

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 16, 2025 16:09


Crypto News: Uncertainty hits investors in the Crypto market as Bitcoin stalls and War rises in the middle east. Trump Media gets SEC Approval for share sell to buy Bitcoin.Show Sponsor -

Thinking Crypto Interviews & News
Avalanche (AVAX) Adoption is Surging! FIFA, Gaming, & $290 Billion Real Estate Tokenization! with Luigi D'Onorio DeMeo

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 16, 2025 46:04


Luigi D'Onorio DeMeo, Chief Strategy Officer at Ava Labs, joined me to discuss the latest developments and major projects being built on the Avalanche blockchain.Topics:- Why Avalanche is different from other Blockchains - How Avalanche achieves high speed and low transaction fees - FIFA building on Avalanche - $290 Billion in Real Estate on Avalanche - Gaming on Avalanche - US Crypto Outlook Show Sponsor -

Thinking Crypto Interviews & News
Coinbase CEO Brian Armstrong Talks the Future of Crypto!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 16, 2025 5:46


I interviewed Coinbase CEO Brian Armstrong at the Coinbase State of Crypto Summit. He shares his outlook on Coinbase, discusses new products such as the Coinbase One credit card and the Shopify partnership, and gives his perspective on crypto legislation in the U.S.

Thinking Crypto Interviews & News
AMAZON & WALMART TO LAUNCH STABLECOINS! HUGE XRP, CARDANO, & ETHEREUM NEWS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 14, 2025 12:09


Crypto News: The WSJ is reporting that Amazon and Walmart are looking to launch their own stablecoins. Stablecoin bill could get passed on Tuesday. Trident Digital aims to raise $500 million to create a corporate treasury focused on XRP. Cardano's Charles Hoskinson proposed converting $100M of ADA into bitcoin and stablecoins.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Thinking Crypto Interviews & News
BLACKROCK WANTS TO TAKEOVER CRYPTO! USDC STABLECOIN XRP LEDGER!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 13, 2025 11:12


Crypto News: BlackRock looks to become the world's largest crypto asset manager by 2030. Circle launches USDC stablecoin on the XRP Ledger. Stablecoin Bill Genius Act could be passed by next week. Show Sponsor -

Thinking Crypto Interviews & News
HUGE ALTCOIN NEWS! XRP FLARE ADOPTION! ONDO TOKENIZATION XRPL! STABLECOIN BILL PROGRESS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 12, 2025 12:12


The Edge Podcast
FAIR: SKALE's New L1 To Eliminate MEV and Unlock AI-Powered DeFi

The Edge Podcast

Play Episode Listen Later Jun 11, 2025 56:42


Jack O'Holleran is the CoFounder of SKALE and CEO at SKALE Labs.In this episode, Jack breaks down why they built FAIR, a new L1 blockchain designed to eliminate MEV at the consensus level and unlock a new wave of AI and DeFi applications.------

The PainExam podcast
The Phenol Celiac Plexus Block & the Pain Boards Community Chat Room!

The PainExam podcast

Play Episode Listen Later Jun 11, 2025 14:34


  Summary In this Pain Exam Podcast episode, Dr. David Rosenblum discusses a journal club article on low volume neurolytic retrocrural celiac plexus blocks for visceral cancer pain. The study reviewed 507 patients with severe malignancy-related abdominal pain, with data retained for 455 patients at the 5-month mark. Dr. Rosenblum explains that the procedure involves injecting 3-5ml of 6% aqueous phenol at the T12-L1 level under fluoroscopic guidance, with an average procedure time of 16.3 minutes. The study found significant pain relief lasting up to six months, reduced opioid consumption, and improved quality of life for patients with primary abdominal cancer or metastatic disease. Dr. Rosenblum shares his personal experience with celiac plexus blocks, including the trans-aortic approach he trained on, and mentions his interest in ultrasound-guided approaches. He also announces upcoming teaching engagements at ASPN, Pain Week, and other conferences, as well as CME ultrasound courses available through nrappain.org. Additionally, he mentions a new community page on the website where users can share board preparation information, though he emphasizes that remembered board questions should not be posted as he is a board question writer himself. Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights Introduction and Upcoming Events Dr. David Rosenblum introduces the Pain Exam Podcast and shares information about upcoming events. He mentions teaching ultrasound at ASPN in July, attending Pain Week in September, and participating in the Latin American Pain Society conference. Dr. Rosenblum also promotes his CME ultrasound courses available at nrappain.org and mentions he's considering organizing another regenerative medicine course in fall or winter. He offers private training for those wanting more intensive ultrasound instruction. Board Prep Community Announcement Dr. Rosenblum announces a new community page on the nrappain.org website for board preparation. He explains that registered users can access free information and keywords relevant to board exams. He emphasizes that users should not post remembered questions as this would be inappropriate, noting that he himself is a board question writer for various pain boards. Dr. Rosenblum mentions that a post about phenol in this community inspired today's podcast topic. Journal Article Overview on Celiac Plexus Block Dr. Rosenblum introduces a journal article on low volume neurolytic retrocrural celiac plexus block for visceral cancer pain, a retrospective review of 507 patients with severe malignancy-related abdominal pain. He explains that the study assessed pain relief provided by this procedure, its duration, reduction in daily opioid consumption, and quality of life improvements. The patients received neurolytic blocks without previous diagnostic blocks due to multiple comorbidities, which Dr. Rosenblum acknowledges is sometimes necessary with very sick patients despite the typical preference for diagnostic blocks before neurolysis. Dr. Rosenblum's Personal Experience with Celiac Plexus Blocks Dr. Rosenblum shares his personal training experience with trans-aortic celiac plexus blocks, where a needle is inserted through the aorta after confirming no plaques or aneurysms are present. He describes it as a safe and effective procedure despite sounding intimidating. He mentions he's only performed a handful of these procedures and doesn't do many now as an outpatient pain doctor. Study Methods and Results Dr. Rosenblum details the study methods, noting that of 507 patients studied, data for 455 was retained at the end of the review. Patients were evaluated before and after the neurolytic retrocrural celiac plexus block under fluoroscopic guidance. Assessment included procedure duration, pain scores (0-10 scale), daily opioid consumption, and quality of life improvement. Follow-up was completed six months after the procedure, showing improved pain scores, reduced opioid consumption, and better quality of life throughout the study period. Some pain returned during months 4-6 due to disease progression and the anticipated duration of the neurolytic agent. The study noted a 6.7% initial vascular contrast uptake during the procedure while using digital subtraction angiography with fluoroscopy. Study Limitations and Conclusions Dr. Rosenblum discusses the study's limitations, including the need for a larger sample size and a prospective trial with a control group, though he acknowledges this is unrealistic given the patient population. He mentions that a proven quality of life questionnaire would be beneficial, and that comparing alcohol, phenol, and RF thermocoagulation would be interesting to evaluate duration effects and side effects. The study concluded that low volume neurolytic retrocrural celiac plexus block with phenol is safe, providing up to six months of pain relief for abdominal pain due to primary malignancy or metastatic spread. Detailed Procedure Technique Dr. Rosenblum explains the detailed procedure technique used in the study. The retrocrural celiac plexus was targeted at L1 level with aim towards T12. Anterior and posterior radiographic imaging aligning the spinous process of T12-L1 junction was used with 15-20 degree oblique rotation. Local anesthetic (1% lidocaine with sodium bicarbonate) was infiltrated along the injection path. A 22 or 25 gauge 3.5-7 inch curved spinal needle was used depending on patient body habitus. Dr. Rosenblum notes he typically uses a 6-inch Chiba needle or 25 gauge spinal needle for such procedures. Procedure Execution and Monitoring Dr. Rosenblum continues describing the procedure, noting that the needle was advanced to the anterior border of T12-L1 under multiple imaging views. Contrast dye studies verified spread and location, with digital subtraction angiography used to check for intravascular uptake. A test dose of 1ml of 0.5% bupivacaine with epinephrine per site was administered, which Dr. Rosenblum finds interesting as he typically doesn't mix bupivacaine with epinephrine. After confirming no vascular uptake, 3-5ml of 6% aqueous phenol was injected in 1ml aliquots while communicating with the patient. The average procedure time was 16.3 minutes with minimal or no sedation. Patients remained prone for 30 minutes afterward to avoid neuroforaminal spread, as phenol is heavier and more viscous than alcohol. Post-Procedure Care and Study Evaluation Dr. Rosenblum explains that patients were monitored in recovery for one hour for adverse events and their ability to eat and void easily. They were discharged once hospital post-anesthetic criteria were met and received a follow-up call 24 hours later. Dr. Rosenblum praises the study and notes that the procedure looks similar to a lumbar sympathetic plexus block, which is also a sympathetic block. Ultrasound Considerations and Alternative Approaches Dr. Rosenblum shares his interest in ultrasound-guided celiac plexus blocks but acknowledges concerns about bowel perforation. He mentions a conversation with an interventional radiology colleague who suggested a transhepatic approach. Dr. Rosenblum recalls scanning a very thin patient where the aorta was easily visible and close to the anterior abdominal wall, making the celiac plexus potentially accessible if bowel perforation, liver bleeding, or gallbladder perforation could be avoided. He shares an experience with a patient suffering from severe pancreatitis pain who received temporary relief from a paravertebral thoracic nerve block at T8-T10, noting that paravertebral blocks provide some sympathetic spread. Conclusion and Community Resource Reminder Dr. Rosenblum concludes by recommending the article, noting its well-written analysis and graphs showing morphine consumption dropping over months following the procedure. He suggests neurolytic procedures are underutilized because they sound intimidating. He again encourages listeners to check out the community he created with separate chat rooms for regenerative medicine, regional anesthesia, and pain boards, where users can share keywords but not specific board questions. Dr. Rosenblum reminds listeners about upcoming courses and his website resources, mentions an upcoming PRP lecture, and asks for five-star reviews if listeners enjoy the podcast. The episode ends with a standard medical disclaimer. Reference https://www.painphysicianjournal.com/current/pdf?article=NTQwOA%3D%3D&journal=113

Thinking Crypto Interviews & News
SEC CHAIR PAUL ATKINS BULLISH CRYPTO STATEMENTS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 10, 2025 14:13


Crypto News: SEC Chair Paul Atkins talks crypto self custody at SEC roundtable today. Nasdaq confirms XRP, SOL, ADA, and XLM in benchmark index via new SEC filing. The Stablecoin Genius ACT Bill could be passed this week.Show Sponsor -

Thinking Crypto Interviews & News
Ethereum & Solana Institutional DeFi is on the Rise! - Nic Roberts-Huntley

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 10, 2025 41:15


Nic Roberts-Huntley, co-founder and CEO of Blueprint Finance, joined me to discuss how institutions can earn yield with new DeFi platforms on Ethereum and Solana.Topics: - Blueprint Finance DeFi Solutions - Building on Ethereum and Solana - Institutional demand for DeFi - Future of DeFi - Outlook on Crypto in the US Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

AWS for Software Companies Podcast
Ep106: Building Secure and Agile AI Agents at Scale with Anthropic and AWS

AWS for Software Companies Podcast

Play Episode Listen Later Jun 10, 2025 37:20


Security leaders from Anthropic and AWS discuss how agentic AI is transforming cybersecurity functions to autonomously handle everything from code reviews to SOC operations.Topics Include:Agentic AI differs from traditional AI through autonomy and agencyTraditional AI handles single workflow nodes, agents collapse multiple stepsHigher model intelligence enables understanding of broader business contextsAgents make intelligent decisions across complex multi-step workflows processesEnterprise security operations are seeing workflow consolidation through GenAIOrganizations embedding GenAI directly into customer-facing production applicationsSoftware-as-a-service transitioning to service-as-software through AI agentsSecuring AI requires guardrails to prevent hallucinations in applicationsNew vulnerabilities appear at interaction points between system componentsAttackers target RAG systems and identity/authorization layers insteadLLMs hallucinate non-existent packages, attackers create malicious honeypotsGovernance frameworks must be machine-readable for autonomous agent reasoningAmazon investing in automated reasoning to prove software correctnessAnthropic uses Claude to write over 50% of codeAutomated code review systems integrated into CI/CD pipelinesSecurity design reviews use MITRE ATT&CK framework automationLow-risk assessments enable developers to self-approve security reviews40% reduction in application security team review workloadAnthropic eliminated SOC, replaced entirely with Claude-based automationIT support roles transitioning to engineering as automation replaces frontlineCompliance questionnaires fully automated using agentic AI workflowsISO 42001 framework manages AI deployment risks alongside securityExecutive risk councils evaluate AI risks using traditional enterprise processesAWS embeds GenAI into testing, detection, and user experienceFinding summarization helps L1 analysts understand complex AWS environmentsAmazon encourages teams to "live in the future" with AIInterview candidates expected to demonstrate Claude usage during interviewsSecurity remains biggest barrier to enterprise AI adoption beyond POCsVirtual employees predicted to arrive within next 12 monthsModel Context Protocol (MCP) creates new supply chain security risksParticipants:Jason Clinton – Chief Information Security Officer, AnthropicGee Rittenhouse – Vice President, Security Services, AWSHart Rossman – Vice President, Global Services Security, AWSBrian Shadpour – GM of Security and B2B Software Sales, AWSSee how Amazon Web Services gives you the freedom to migrate, innovate, and scale your software company at https://aws.amazon.com/isv/

Thinking Crypto Interviews & News
XRP ADOPTION TO SURGE IN JAPAN & DEUTSCHE BANK WANTS STABLECOINS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 9, 2025 21:25


Crypto News: Ripple and Web3 Salon are launching a new partnership for Japan-based Web3 startups to build on the XRP Ledger. Deutsche Bank is exploring stablecoins and tokenized deposits as part of its digital assets strategy. Show Sponsor -

Thinking Crypto Interviews & News
Why Web3 Will Change the World with Yat Siu

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 9, 2025 79:22


Yat Siu, Co-founder and Chairman of Animoca Brands, joined me to discuss how Web3 will transform the world and how businesses and individuals can adapt to this emerging technology. Topics:- Why people should care about Web3 - How Bitcoin fits in Web3 - How Businesses can use Web3 tech to improve customer retention - Sony's Blockchain - Web3 Gaming - Digital currency in the Space economy - Tokenized assets & NFTs Show Sponsor -

Thinking Crypto Interviews & News
BIG CRYPTO NEWS! UBER, APPLE, AIRBNB & MORE WILL ADOPT STABLECOINS!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 7, 2025 14:26


Crypto News: Uber CEO says they are looking at integrating stablecoins. Apple, X, Airbnb, Google are also exploring stablecoins. Gemini crypto exchange files for an IPO.Show Sponsor -

Thinking Crypto Interviews & News
Will Crypto Rebound Soon? Bitcoin, XRP, Ethereum, & Solana Analysis!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 7, 2025 38:32


Thinking Crypto Interviews & News
Bitcoin Drops as Trump and Musk Go Wild Online! Circle Goes Public on NYSE!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 6, 2025 15:46


Crypto News: Bitcoin dumps as uncertainty with President Trump and Elon Musk rises. Circle goes public on the NYSE.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/

Thinking Crypto Interviews & News
Former Head of IRS Digital Assets Reveals What Happens Next for Crypto - Sulolit Raj Mukherjee

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 5, 2025 64:20


Sulolit Raj Mukherjee, Founder and CEO of Bodin Advisory, joined me to discuss his time at the IRS and how the IRS will handle crypto moving forward. https://bodin-advisory.com/Topics:- Raj's time in TradFi, Crypto, & at the IRS - IRS' approach to Crypto - IRS DeFi Broker Rule repealed - Upcoming Tax Docs for Crypto - Future of Crypto in the US Show Sponsor -

Thinking Crypto Interviews & News
Robinhood Just Made a Big Crypto Move! BitGo Vivo Power $100 Million XRP!

Thinking Crypto Interviews & News

Play Episode Listen Later Jun 3, 2025 11:02