Podcasts about L1

Crypto News: Bloomberg ETF analyst raise XRP and Solana ETF approvals to 90%. Depository Trust & Clearing Corporation(DTCC) met with SEC Crypto Task Force today to discuss tokenization. Show Sponsor -

I interviewed Max Branzburg, VP of Product at Coinbase, at the Coinbase State of Crypto Summit. We discussed Coinbase's crypto-backed loans, which allow users to borrow against their Bitcoin and receive the loan in USDC.

Brian from Santiment joined me to review the current state of the crypto bull market and dive into key metrics for Bitcoin, XRP, Ethereum, and Solana.

Crypto News: Trump family's company cuts stake in World Liberty Financial by 20%. Blockchain can solve world's largest data breach affecting Apple, Google, Facebook and more. Circle Rockets After Stablecoin Bill Clears Senate.Show Sponsor -

Cody Carbone, CEO of The Digital Chamber, joined me to discuss the state of the Stablecoin and Crypto Market structure bills as they make their way through the legislative process.Topics:- Stablecoin Bill passes in the Senate, How fast can it pass in the House? - State of the Crypto Market Structure Bills - Is the Crypto Industry reviewing the Bills - Will Tether be affected by the US Stablecoin Legislation - SEC's new approach to Crypto - Upcoming Crypto Hearings Show Sponsor -

I interviewed Brett Tejpaul, Head of Coinbase Institutional, at the Coinbase State of Crypto Summit. We discussed the rising institutional demand for crypto and Coinbase's suite of institutional services.

Crypto News: XRP ETF goes live on Toronto Stock Exchange. Coinbase adds XRP DeFi via Base and Moonwell. Trump posts about stablecoin bill passing in Senate and that he is ready to sign. Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/

Tu passes en L2 ?Tu es sur le point de te prendre un gros revers si tu crois que ça va ressembler à ta L1.Prof moins indulgents, matières plus techniques, copies massacrées dès septembre…Chaque année, j'ai des étudiantes brillantes qui se ramassent parce qu'elles n'ont pas compris que la L2, ça se prépare autrement.Dans cet épisode, je t'explique :– ce qui change vraiment entre la L1 et la L2– pourquoi ta méthode de travail doit évoluer– et comment éviter de finir avec des 3 ou des 4 aux premières colles

I interviewed Paul Grewal, Chief Legal Officer at Coinbase, at the Coinbase State of Crypto Summit. We discussed the shifting approach to crypto by the SEC and the U.S. government, Coinbase's ongoing fight for regulatory clarity, and much more.

Crypto News: Senate passes the stablecoin legislation bill the GENIUS Act. JPMorgan launches a deposit token on Base, Coinbase's Ethereum Layer 2.Show Sponsor -

Hyperliquid is one of the most talked-about platforms in crypto right now. It's an onchain perpetuals exchange that sidestepped VCs, built a deeply loyal user base, and launched with transparency most rivals avoid. But it's also staring down some massive challenges—from incoming competitors like Coinbase and Robinhood, to the technical hurdles of decentralizing its core exchange engine. Arthur Hayes, CIO of Maelstrom and one of crypto's most iconic traders, and Hanson Birringer of Flowdesk discuss: What actually drove Hyperliquid's success How a user-first approach is outpacing venture-backed models Whether the James Wynn saga was legit Why the HIP-3 proposal could be the “holy grail” for DEXes And whether Hyperliquid can survive its next big test: the entrance of giants Visit our website for breaking news, analysis, op-eds, articles to learn about crypto, and much more: unchainedcrypto.com Thank you to our sponsors! Xapo Bank Bitwise Guests: Arthur Hayes, CIO of Maelstrom Hanson Birringer, Head of US Sales at Flowdesk Links Stats: CoinGlass: Total BTC Futures Open Interest Hyperliquid Stats James Wynn Unchained: Hyperliquid Trader Makes $87M in 70 Days, Loses It In Five James Wynn's address  Transparency Hyperliquid's founder's post on X saying that he felt like transparency results in better execution for whales compared to on private venues. Hyperliquid vs Binance: Unchained: Hyperliquid Saved Itself a $15 Million Loss, but Sparked Criticism Arthur Hayes' tweet on whether $HYPE perp volumes will flip Binance's this cycle. CZ's tweet on dark pool DEXs Cointelegraph: Binance co-founder CZ proposes dark pool DEXs to tackle manipulation Tokenomics: DL News: Hyperliquid's token buyback machine just hit $1b — is it sustainable? HIP-3: Hyperliquid Docs: HIP-3: Builder-Deployed Perpetuals Timestamps:

Crypto News: JPMorgan files for Stablecoin trademark. XRP ETF will go live on the Toronto stock exchange. Donald Trump's Truth Social files for Dual Bitcoin and Ether ETF.Show Sponsor -

Ash Pampati, Head of Ecosystem at the Aptos Foundation, joined me to discuss the future of Web3 and Aptos' role in shaping it.Topics:- How platforms such as YouTube and Spotify will embrace Web3 - Creator Economy and Web3 - What makes Aptos different from other Blockchains - $200 Million DeFi grants - Rhuna, an AI-driven white-label event infrastructure platform, partnership - US Crypto Legislation Outlook Show Sponsor -

I interviewed Jesse Pollak,Head of Base and Coinbase Wallet, at the Coinbase State of Crypto Summit. He discusses the latest and great with adoption on Base and the Coinbase wallet.

USL League One spreading out West is an essential part of the plan over the next few years (“Manifest Destiny for L1”). Forming a Western Division would cut down on travel costs and make a 3rd tier professional club more affordable to operate. It is cities like Boise that are the perfect fit for joining the USL Western Front. The intrigue for the city as a potential soccer hotbed piqued after two friendlies produced sell-out results in the recent history. There was an Athletic Bilbao vs Liga MX Club Tijuana in 2015 that drew nearly 22k people into Boise State (where the infamous blue turf was covered with grass for the event…). Then there was a very unique event - where a USL Championship regular season league game took place (Portland Timbers II vs Swope Park Rangers) in 2016 at a High School in Boise and sold out the field at 4,350 people. The feeling of it being a good fit for USL is proving to be true as the club have already sold 3,500 season tickets for their USL League One Inaugural year. That is even without the branding in place (which is set to be released on June 27th). There was a brief period where the local Minor League Ownership group (of Boise Hawks) was speaking with USL to get a USL Championship squad. But Covid changed the narrative there. Now the timing is right and an All Star Front Office composed of four individuals - each with a different, unique specialty, are the ones backing this new project. There's NBA Executive experience, US Soccer Experience, Idaho Youth Soccer, and Real Estate Development experience all coming together to give this project legs. The Stadium project is perhaps one of the best stadium projects in the Country at the moment as well. They are converting an old horse racing track into a 6,000 fan soccer-specific stadium that has an incredible mountain backdrop. Phase 2 of the stadium project, which will hopefully be necessary as USL institutes promotion/relegation, would add an additional 5,000 seats for a capacity of 11,000 people. Needless to say, I'm looking forward to watching how things unfold in Boise, Idaho and I appreciate Bill Taylor for taking the time to speak with me. Here's a snippet of our conversation. If you want the full videos, visit our YouTube channel here.

Hyperliquid is one of the most talked-about platforms in crypto right now. It's an onchain perpetuals exchange that sidestepped VCs, built a deeply loyal user base, and launched with transparency most rivals avoid. But it's also staring down some massive challenges—from incoming competitors like Coinbase and Robinhood, to the technical hurdles of decentralizing its core exchange engine. Arthur Hayes, CIO of Maelstrom and one of crypto's most iconic traders, and Hanson Birringer of Flowdesk discuss: What actually drove Hyperliquid's success How a user-first approach is outpacing venture-backed models Whether the James Wynn saga was legit Why the HIP-3 proposal could be the “holy grail” for DEXes And whether Hyperliquid can survive its next big test: the entrance of giants Visit our website for breaking news, analysis, op-eds, articles to learn about crypto, and much more: unchainedcrypto.com Thank you to our sponsors! Xapo Bank Bitwise Guests: Arthur Hayes, CIO of Maelstrom Hanson Birringer, Head of US Sales at Flowdesk Links Stats: CoinGlass: Total BTC Futures Open Interest Hyperliquid Stats James Wynn Unchained: Hyperliquid Trader Makes $87M in 70 Days, Loses It In Five James Wynn's address  Transparency Hyperliquid's founder's post on X saying that he felt like transparency results in better execution for whales compared to on private venues. Hyperliquid vs Binance: Unchained: Hyperliquid Saved Itself a $15 Million Loss, but Sparked Criticism Arthur Hayes' tweet on whether $HYPE perp volumes will flip Binance's this cycle. CZ's tweet on dark pool DEXs Cointelegraph: Binance co-founder CZ proposes dark pool DEXs to tackle manipulation Tokenomics: DL News: Hyperliquid's token buyback machine just hit $1b — is it sustainable? HIP-3: Hyperliquid Docs: HIP-3: Builder-Deployed Perpetuals Timestamps:

I interviewed Coinbase CEO Brian Armstrong at the Coinbase State of Crypto Summit. He shares his outlook on Coinbase, discusses new products such as the Coinbase One credit card and the Shopify partnership, and gives his perspective on crypto legislation in the U.S.

Crypto News: Uncertainty hits investors in the Crypto market as Bitcoin stalls and War rises in the middle east. Trump Media gets SEC Approval for share sell to buy Bitcoin.Show Sponsor -

Luigi D'Onorio DeMeo, Chief Strategy Officer at Ava Labs, joined me to discuss the latest developments and major projects being built on the Avalanche blockchain.Topics:- Why Avalanche is different from other Blockchains - How Avalanche achieves high speed and low transaction fees - FIFA building on Avalanche - $290 Billion in Real Estate on Avalanche - Gaming on Avalanche - US Crypto Outlook Show Sponsor -

Crypto News: The WSJ is reporting that Amazon and Walmart are looking to launch their own stablecoins. Stablecoin bill could get passed on Tuesday. Trident Digital aims to raise $500 million to create a corporate treasury focused on XRP. Cardano's Charles Hoskinson proposed converting $100M of ADA into bitcoin and stablecoins.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Crypto News: BlackRock looks to become the world's largest crypto asset manager by 2030. Circle launches USDC stablecoin on the XRP Ledger. Stablecoin Bill Genius Act could be passed by next week. Show Sponsor -

Crypto News: Vivo Power will put $100 Million in XRP on Flare (FLR) to arn yield. Ondo Finance tokenization on the XRP Ledger. Bank of America confirms stablecoin development.Show Sponsor -

Crypto News: Bloomberg iETF analysts are reporting that the SEC could approve Altcoin ETF such as XRP, Solana and more this summer.Show Sponsor -

Jack O'Holleran is the CoFounder of SKALE and CEO at SKALE Labs.In this episode, Jack breaks down why they built FAIR, a new L1 blockchain designed to eliminate MEV at the consensus level and unlock a new wave of AI and DeFi applications.------

  Summary In this Pain Exam Podcast episode, Dr. David Rosenblum discusses a journal club article on low volume neurolytic retrocrural celiac plexus blocks for visceral cancer pain. The study reviewed 507 patients with severe malignancy-related abdominal pain, with data retained for 455 patients at the 5-month mark. Dr. Rosenblum explains that the procedure involves injecting 3-5ml of 6% aqueous phenol at the T12-L1 level under fluoroscopic guidance, with an average procedure time of 16.3 minutes. The study found significant pain relief lasting up to six months, reduced opioid consumption, and improved quality of life for patients with primary abdominal cancer or metastatic disease. Dr. Rosenblum shares his personal experience with celiac plexus blocks, including the trans-aortic approach he trained on, and mentions his interest in ultrasound-guided approaches. He also announces upcoming teaching engagements at ASPN, Pain Week, and other conferences, as well as CME ultrasound courses available through nrappain.org. Additionally, he mentions a new community page on the website where users can share board preparation information, though he emphasizes that remembered board questions should not be posted as he is a board question writer himself. Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights Introduction and Upcoming Events Dr. David Rosenblum introduces the Pain Exam Podcast and shares information about upcoming events. He mentions teaching ultrasound at ASPN in July, attending Pain Week in September, and participating in the Latin American Pain Society conference. Dr. Rosenblum also promotes his CME ultrasound courses available at nrappain.org and mentions he's considering organizing another regenerative medicine course in fall or winter. He offers private training for those wanting more intensive ultrasound instruction. Board Prep Community Announcement Dr. Rosenblum announces a new community page on the nrappain.org website for board preparation. He explains that registered users can access free information and keywords relevant to board exams. He emphasizes that users should not post remembered questions as this would be inappropriate, noting that he himself is a board question writer for various pain boards. Dr. Rosenblum mentions that a post about phenol in this community inspired today's podcast topic. Journal Article Overview on Celiac Plexus Block Dr. Rosenblum introduces a journal article on low volume neurolytic retrocrural celiac plexus block for visceral cancer pain, a retrospective review of 507 patients with severe malignancy-related abdominal pain. He explains that the study assessed pain relief provided by this procedure, its duration, reduction in daily opioid consumption, and quality of life improvements. The patients received neurolytic blocks without previous diagnostic blocks due to multiple comorbidities, which Dr. Rosenblum acknowledges is sometimes necessary with very sick patients despite the typical preference for diagnostic blocks before neurolysis. Dr. Rosenblum's Personal Experience with Celiac Plexus Blocks Dr. Rosenblum shares his personal training experience with trans-aortic celiac plexus blocks, where a needle is inserted through the aorta after confirming no plaques or aneurysms are present. He describes it as a safe and effective procedure despite sounding intimidating. He mentions he's only performed a handful of these procedures and doesn't do many now as an outpatient pain doctor. Study Methods and Results Dr. Rosenblum details the study methods, noting that of 507 patients studied, data for 455 was retained at the end of the review. Patients were evaluated before and after the neurolytic retrocrural celiac plexus block under fluoroscopic guidance. Assessment included procedure duration, pain scores (0-10 scale), daily opioid consumption, and quality of life improvement. Follow-up was completed six months after the procedure, showing improved pain scores, reduced opioid consumption, and better quality of life throughout the study period. Some pain returned during months 4-6 due to disease progression and the anticipated duration of the neurolytic agent. The study noted a 6.7% initial vascular contrast uptake during the procedure while using digital subtraction angiography with fluoroscopy. Study Limitations and Conclusions Dr. Rosenblum discusses the study's limitations, including the need for a larger sample size and a prospective trial with a control group, though he acknowledges this is unrealistic given the patient population. He mentions that a proven quality of life questionnaire would be beneficial, and that comparing alcohol, phenol, and RF thermocoagulation would be interesting to evaluate duration effects and side effects. The study concluded that low volume neurolytic retrocrural celiac plexus block with phenol is safe, providing up to six months of pain relief for abdominal pain due to primary malignancy or metastatic spread. Detailed Procedure Technique Dr. Rosenblum explains the detailed procedure technique used in the study. The retrocrural celiac plexus was targeted at L1 level with aim towards T12. Anterior and posterior radiographic imaging aligning the spinous process of T12-L1 junction was used with 15-20 degree oblique rotation. Local anesthetic (1% lidocaine with sodium bicarbonate) was infiltrated along the injection path. A 22 or 25 gauge 3.5-7 inch curved spinal needle was used depending on patient body habitus. Dr. Rosenblum notes he typically uses a 6-inch Chiba needle or 25 gauge spinal needle for such procedures. Procedure Execution and Monitoring Dr. Rosenblum continues describing the procedure, noting that the needle was advanced to the anterior border of T12-L1 under multiple imaging views. Contrast dye studies verified spread and location, with digital subtraction angiography used to check for intravascular uptake. A test dose of 1ml of 0.5% bupivacaine with epinephrine per site was administered, which Dr. Rosenblum finds interesting as he typically doesn't mix bupivacaine with epinephrine. After confirming no vascular uptake, 3-5ml of 6% aqueous phenol was injected in 1ml aliquots while communicating with the patient. The average procedure time was 16.3 minutes with minimal or no sedation. Patients remained prone for 30 minutes afterward to avoid neuroforaminal spread, as phenol is heavier and more viscous than alcohol. Post-Procedure Care and Study Evaluation Dr. Rosenblum explains that patients were monitored in recovery for one hour for adverse events and their ability to eat and void easily. They were discharged once hospital post-anesthetic criteria were met and received a follow-up call 24 hours later. Dr. Rosenblum praises the study and notes that the procedure looks similar to a lumbar sympathetic plexus block, which is also a sympathetic block. Ultrasound Considerations and Alternative Approaches Dr. Rosenblum shares his interest in ultrasound-guided celiac plexus blocks but acknowledges concerns about bowel perforation. He mentions a conversation with an interventional radiology colleague who suggested a transhepatic approach. Dr. Rosenblum recalls scanning a very thin patient where the aorta was easily visible and close to the anterior abdominal wall, making the celiac plexus potentially accessible if bowel perforation, liver bleeding, or gallbladder perforation could be avoided. He shares an experience with a patient suffering from severe pancreatitis pain who received temporary relief from a paravertebral thoracic nerve block at T8-T10, noting that paravertebral blocks provide some sympathetic spread. Conclusion and Community Resource Reminder Dr. Rosenblum concludes by recommending the article, noting its well-written analysis and graphs showing morphine consumption dropping over months following the procedure. He suggests neurolytic procedures are underutilized because they sound intimidating. He again encourages listeners to check out the community he created with separate chat rooms for regenerative medicine, regional anesthesia, and pain boards, where users can share keywords but not specific board questions. Dr. Rosenblum reminds listeners about upcoming courses and his website resources, mentions an upcoming PRP lecture, and asks for five-star reviews if listeners enjoy the podcast. The episode ends with a standard medical disclaimer. Reference https://www.painphysicianjournal.com/current/pdf?article=NTQwOA%3D%3D&journal=113

  Summary In this Pain Exam Podcast episode, Dr. David Rosenblum discusses a journal club article on low volume neurolytic retrocrural celiac plexus blocks for visceral cancer pain. The study reviewed 507 patients with severe malignancy-related abdominal pain, with data retained for 455 patients at the 5-month mark. Dr. Rosenblum explains that the procedure involves injecting 3-5ml of 6% aqueous phenol at the T12-L1 level under fluoroscopic guidance, with an average procedure time of 16.3 minutes. The study found significant pain relief lasting up to six months, reduced opioid consumption, and improved quality of life for patients with primary abdominal cancer or metastatic disease. Dr. Rosenblum shares his personal experience with celiac plexus blocks, including the trans-aortic approach he trained on, and mentions his interest in ultrasound-guided approaches. He also announces upcoming teaching engagements at ASPN, Pain Week, and other conferences, as well as CME ultrasound courses available through nrappain.org. Additionally, he mentions a new community page on the website where users can share board preparation information, though he emphasizes that remembered board questions should not be posted as he is a board question writer himself. Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights Introduction and Upcoming Events Dr. David Rosenblum introduces the Pain Exam Podcast and shares information about upcoming events. He mentions teaching ultrasound at ASPN in July, attending Pain Week in September, and participating in the Latin American Pain Society conference. Dr. Rosenblum also promotes his CME ultrasound courses available at nrappain.org and mentions he's considering organizing another regenerative medicine course in fall or winter. He offers private training for those wanting more intensive ultrasound instruction. Board Prep Community Announcement Dr. Rosenblum announces a new community page on the nrappain.org website for board preparation. He explains that registered users can access free information and keywords relevant to board exams. He emphasizes that users should not post remembered questions as this would be inappropriate, noting that he himself is a board question writer for various pain boards. Dr. Rosenblum mentions that a post about phenol in this community inspired today's podcast topic. Journal Article Overview on Celiac Plexus Block Dr. Rosenblum introduces a journal article on low volume neurolytic retrocrural celiac plexus block for visceral cancer pain, a retrospective review of 507 patients with severe malignancy-related abdominal pain. He explains that the study assessed pain relief provided by this procedure, its duration, reduction in daily opioid consumption, and quality of life improvements. The patients received neurolytic blocks without previous diagnostic blocks due to multiple comorbidities, which Dr. Rosenblum acknowledges is sometimes necessary with very sick patients despite the typical preference for diagnostic blocks before neurolysis. Dr. Rosenblum's Personal Experience with Celiac Plexus Blocks Dr. Rosenblum shares his personal training experience with trans-aortic celiac plexus blocks, where a needle is inserted through the aorta after confirming no plaques or aneurysms are present. He describes it as a safe and effective procedure despite sounding intimidating. He mentions he's only performed a handful of these procedures and doesn't do many now as an outpatient pain doctor. Study Methods and Results Dr. Rosenblum details the study methods, noting that of 507 patients studied, data for 455 was retained at the end of the review. Patients were evaluated before and after the neurolytic retrocrural celiac plexus block under fluoroscopic guidance. Assessment included procedure duration, pain scores (0-10 scale), daily opioid consumption, and quality of life improvement. Follow-up was completed six months after the procedure, showing improved pain scores, reduced opioid consumption, and better quality of life throughout the study period. Some pain returned during months 4-6 due to disease progression and the anticipated duration of the neurolytic agent. The study noted a 6.7% initial vascular contrast uptake during the procedure while using digital subtraction angiography with fluoroscopy. Study Limitations and Conclusions Dr. Rosenblum discusses the study's limitations, including the need for a larger sample size and a prospective trial with a control group, though he acknowledges this is unrealistic given the patient population. He mentions that a proven quality of life questionnaire would be beneficial, and that comparing alcohol, phenol, and RF thermocoagulation would be interesting to evaluate duration effects and side effects. The study concluded that low volume neurolytic retrocrural celiac plexus block with phenol is safe, providing up to six months of pain relief for abdominal pain due to primary malignancy or metastatic spread. Detailed Procedure Technique Dr. Rosenblum explains the detailed procedure technique used in the study. The retrocrural celiac plexus was targeted at L1 level with aim towards T12. Anterior and posterior radiographic imaging aligning the spinous process of T12-L1 junction was used with 15-20 degree oblique rotation. Local anesthetic (1% lidocaine with sodium bicarbonate) was infiltrated along the injection path. A 22 or 25 gauge 3.5-7 inch curved spinal needle was used depending on patient body habitus. Dr. Rosenblum notes he typically uses a 6-inch Chiba needle or 25 gauge spinal needle for such procedures. Procedure Execution and Monitoring Dr. Rosenblum continues describing the procedure, noting that the needle was advanced to the anterior border of T12-L1 under multiple imaging views. Contrast dye studies verified spread and location, with digital subtraction angiography used to check for intravascular uptake. A test dose of 1ml of 0.5% bupivacaine with epinephrine per site was administered, which Dr. Rosenblum finds interesting as he typically doesn't mix bupivacaine with epinephrine. After confirming no vascular uptake, 3-5ml of 6% aqueous phenol was injected in 1ml aliquots while communicating with the patient. The average procedure time was 16.3 minutes with minimal or no sedation. Patients remained prone for 30 minutes afterward to avoid neuroforaminal spread, as phenol is heavier and more viscous than alcohol. Post-Procedure Care and Study Evaluation Dr. Rosenblum explains that patients were monitored in recovery for one hour for adverse events and their ability to eat and void easily. They were discharged once hospital post-anesthetic criteria were met and received a follow-up call 24 hours later. Dr. Rosenblum praises the study and notes that the procedure looks similar to a lumbar sympathetic plexus block, which is also a sympathetic block. Ultrasound Considerations and Alternative Approaches Dr. Rosenblum shares his interest in ultrasound-guided celiac plexus blocks but acknowledges concerns about bowel perforation. He mentions a conversation with an interventional radiology colleague who suggested a transhepatic approach. Dr. Rosenblum recalls scanning a very thin patient where the aorta was easily visible and close to the anterior abdominal wall, making the celiac plexus potentially accessible if bowel perforation, liver bleeding, or gallbladder perforation could be avoided. He shares an experience with a patient suffering from severe pancreatitis pain who received temporary relief from a paravertebral thoracic nerve block at T8-T10, noting that paravertebral blocks provide some sympathetic spread. Conclusion and Community Resource Reminder Dr. Rosenblum concludes by recommending the article, noting its well-written analysis and graphs showing morphine consumption dropping over months following the procedure. He suggests neurolytic procedures are underutilized because they sound intimidating. He again encourages listeners to check out the community he created with separate chat rooms for regenerative medicine, regional anesthesia, and pain boards, where users can share keywords but not specific board questions. Dr. Rosenblum reminds listeners about upcoming courses and his website resources, mentions an upcoming PRP lecture, and asks for five-star reviews if listeners enjoy the podcast. The episode ends with a standard medical disclaimer. Reference https://www.painphysicianjournal.com/current/pdf?article=NTQwOA%3D%3D&journal=113

The OKR Trio is back with Part 2 of their brutally honest Q2 2025 forecast, and they're not holding back. Sara Lobkovich, Maria Rowcliffe, and Natalie Webb tackle the questions you've been asking about rigid vs. flexible OKR approaches, timing models that actually work, and trends we're seeing in tool choices.But here's where it gets spicy: they're sharing their most controversial OKR opinions, speed round style! From leaders trying to weaponize OKRs as surveillance tools to the popular (but problematic) advice to limit teams to just one strategic priority, this conversation will challenge norms you might not be able to imagine actually exist out there.You'll discover why monthly check-ins might mean you're tracking instead of managing, how geography is shaping OKR strategy differently across continents, and why Excel is making a surprising comeback in the enterprise. Plus, Sara drops a financial metrics hot take that might make your CFO squirm.This isn't your typical goal-setting advice. It's three veteran practitioners sharing what they're really seeing in the field, complete with the controversies, contradictions, and hard-won insights that only come from years in the trenches.Episode Highlights:Quarterly vs. Trimesterly Planning: why the Q4 “drop-off” is real—and how cadence choices impact OKR adoption across teamsBiweekly Reinforcement Loops: how one leadership team's consistent review rhythm is accelerating organization-wide buy-inTool Sprawl & Excel Resurgence: why many orgs are ditching premium OKR platforms for scrappier, process-first setupsWhen Tools Hurt More Than Help: the danger of letting project management tools define your key resultsHot Takes on OKRs: financial metrics don't belong in key results (and one-size-fits-all “just one OKR” advice? Hard pass)Big Brother OKRs?: pushing back when leadership wants to use OKRs for surveillance instead of strategyQ3 Preview: a deep dive on execution, achievement—and how to actually decide what OKR tooling makes sense for your orgKey Concepts Explored:Hybrid Localization ApproachesLeadership sets objectives, teams shape Key ResultsThemes as bridges when objectives don't translate locallyKRs and Sub-KRs for fast-moving Scrum teamsMoving away from rigid objective cascadingTiming Model EvolutionBiweekly check-ins integrated with Scrum cyclesThe discipline of at least twice-weekly KR managementQuarterly vs. trimester cycle trade-offsEvent-triggered OKR adjustments for volatile environmentsTool Integration StrategiesProcess-first, tool-second implementation approachExcel resurgence due to cost considerationsAvoiding dueling OKR and project management platformsRecognition that L1 and L2 math doesn't require specialty softwareControversial Practices and Hot TakesOKRs as surveillance tools (problematic)Arbitrary "one OKR only" mandates (counterproductive)Financial metrics as KPIs vs. Key Results (contentious)Project deliverables masquerading as OKRs (misleading)Notable Quotes: "If you have a KR that you only manage monthly, you are not managing it, you're tracking it. Because you essentially have two data points, and then the quarter is over." — Maria Rowcliffe [00:06:00]"Once we learn the words and leadership is modeling the words and meanings, then the rigidity can come out of the framework." — Sara Lobkovich [00:04:00]"Financial metrics belong in mandatories and budgets. They're KPIs, they aren't key results." — Sara Lobkovich [00:15:00]"Bad news only gets worse with time. So the earlier they can

Crypto News: SEC Chair Paul Atkins talks crypto self custody at SEC roundtable today. Nasdaq confirms XRP, SOL, ADA, and XLM in benchmark index via new SEC filing. The Stablecoin Genius ACT Bill could be passed this week.Show Sponsor -

Nic Roberts-Huntley, co-founder and CEO of Blueprint Finance, joined me to discuss how institutions can earn yield with new DeFi platforms on Ethereum and Solana.Topics: - Blueprint Finance DeFi Solutions - Building on Ethereum and Solana - Institutional demand for DeFi - Future of DeFi - Outlook on Crypto in the US Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Security leaders from Anthropic and AWS discuss how agentic AI is transforming cybersecurity functions to autonomously handle everything from code reviews to SOC operations.Topics Include:Agentic AI differs from traditional AI through autonomy and agencyTraditional AI handles single workflow nodes, agents collapse multiple stepsHigher model intelligence enables understanding of broader business contextsAgents make intelligent decisions across complex multi-step workflows processesEnterprise security operations are seeing workflow consolidation through GenAIOrganizations embedding GenAI directly into customer-facing production applicationsSoftware-as-a-service transitioning to service-as-software through AI agentsSecuring AI requires guardrails to prevent hallucinations in applicationsNew vulnerabilities appear at interaction points between system componentsAttackers target RAG systems and identity/authorization layers insteadLLMs hallucinate non-existent packages, attackers create malicious honeypotsGovernance frameworks must be machine-readable for autonomous agent reasoningAmazon investing in automated reasoning to prove software correctnessAnthropic uses Claude to write over 50% of codeAutomated code review systems integrated into CI/CD pipelinesSecurity design reviews use MITRE ATT&CK framework automationLow-risk assessments enable developers to self-approve security reviews40% reduction in application security team review workloadAnthropic eliminated SOC, replaced entirely with Claude-based automationIT support roles transitioning to engineering as automation replaces frontlineCompliance questionnaires fully automated using agentic AI workflowsISO 42001 framework manages AI deployment risks alongside securityExecutive risk councils evaluate AI risks using traditional enterprise processesAWS embeds GenAI into testing, detection, and user experienceFinding summarization helps L1 analysts understand complex AWS environmentsAmazon encourages teams to "live in the future" with AIInterview candidates expected to demonstrate Claude usage during interviewsSecurity remains biggest barrier to enterprise AI adoption beyond POCsVirtual employees predicted to arrive within next 12 monthsModel Context Protocol (MCP) creates new supply chain security risksParticipants:Jason Clinton – Chief Information Security Officer, AnthropicGee Rittenhouse – Vice President, Security Services, AWSHart Rossman – Vice President, Global Services Security, AWSBrian Shadpour – GM of Security and B2B Software Sales, AWSSee how Amazon Web Services gives you the freedom to migrate, innovate, and scale your software company at https://aws.amazon.com/isv/

  Summary In this Pain Exam Podcast episode, Dr. David Rosenblum discusses a journal club article on low volume neurolytic retrocrural celiac plexus blocks for visceral cancer pain. The study reviewed 507 patients with severe malignancy-related abdominal pain, with data retained for 455 patients at the 5-month mark. Dr. Rosenblum explains that the procedure involves injecting 3-5ml of 6% aqueous phenol at the T12-L1 level under fluoroscopic guidance, with an average procedure time of 16.3 minutes. The study found significant pain relief lasting up to six months, reduced opioid consumption, and improved quality of life for patients with primary abdominal cancer or metastatic disease. Dr. Rosenblum shares his personal experience with celiac plexus blocks, including the trans-aortic approach he trained on, and mentions his interest in ultrasound-guided approaches. He also announces upcoming teaching engagements at ASPN, Pain Week, and other conferences, as well as CME ultrasound courses available through nrappain.org. Additionally, he mentions a new community page on the website where users can share board preparation information, though he emphasizes that remembered board questions should not be posted as he is a board question writer himself. Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights Introduction and Upcoming Events Dr. David Rosenblum introduces the Pain Exam Podcast and shares information about upcoming events. He mentions teaching ultrasound at ASPN in July, attending Pain Week in September, and participating in the Latin American Pain Society conference. Dr. Rosenblum also promotes his CME ultrasound courses available at nrappain.org and mentions he's considering organizing another regenerative medicine course in fall or winter. He offers private training for those wanting more intensive ultrasound instruction. Board Prep Community Announcement Dr. Rosenblum announces a new community page on the nrappain.org website for board preparation. He explains that registered users can access free information and keywords relevant to board exams. He emphasizes that users should not post remembered questions as this would be inappropriate, noting that he himself is a board question writer for various pain boards. Dr. Rosenblum mentions that a post about phenol in this community inspired today's podcast topic. Journal Article Overview on Celiac Plexus Block Dr. Rosenblum introduces a journal article on low volume neurolytic retrocrural celiac plexus block for visceral cancer pain, a retrospective review of 507 patients with severe malignancy-related abdominal pain. He explains that the study assessed pain relief provided by this procedure, its duration, reduction in daily opioid consumption, and quality of life improvements. The patients received neurolytic blocks without previous diagnostic blocks due to multiple comorbidities, which Dr. Rosenblum acknowledges is sometimes necessary with very sick patients despite the typical preference for diagnostic blocks before neurolysis. Dr. Rosenblum's Personal Experience with Celiac Plexus Blocks Dr. Rosenblum shares his personal training experience with trans-aortic celiac plexus blocks, where a needle is inserted through the aorta after confirming no plaques or aneurysms are present. He describes it as a safe and effective procedure despite sounding intimidating. He mentions he's only performed a handful of these procedures and doesn't do many now as an outpatient pain doctor. Study Methods and Results Dr. Rosenblum details the study methods, noting that of 507 patients studied, data for 455 was retained at the end of the review. Patients were evaluated before and after the neurolytic retrocrural celiac plexus block under fluoroscopic guidance. Assessment included procedure duration, pain scores (0-10 scale), daily opioid consumption, and quality of life improvement. Follow-up was completed six months after the procedure, showing improved pain scores, reduced opioid consumption, and better quality of life throughout the study period. Some pain returned during months 4-6 due to disease progression and the anticipated duration of the neurolytic agent. The study noted a 6.7% initial vascular contrast uptake during the procedure while using digital subtraction angiography with fluoroscopy. Study Limitations and Conclusions Dr. Rosenblum discusses the study's limitations, including the need for a larger sample size and a prospective trial with a control group, though he acknowledges this is unrealistic given the patient population. He mentions that a proven quality of life questionnaire would be beneficial, and that comparing alcohol, phenol, and RF thermocoagulation would be interesting to evaluate duration effects and side effects. The study concluded that low volume neurolytic retrocrural celiac plexus block with phenol is safe, providing up to six months of pain relief for abdominal pain due to primary malignancy or metastatic spread. Detailed Procedure Technique Dr. Rosenblum explains the detailed procedure technique used in the study. The retrocrural celiac plexus was targeted at L1 level with aim towards T12. Anterior and posterior radiographic imaging aligning the spinous process of T12-L1 junction was used with 15-20 degree oblique rotation. Local anesthetic (1% lidocaine with sodium bicarbonate) was infiltrated along the injection path. A 22 or 25 gauge 3.5-7 inch curved spinal needle was used depending on patient body habitus. Dr. Rosenblum notes he typically uses a 6-inch Chiba needle or 25 gauge spinal needle for such procedures. Procedure Execution and Monitoring Dr. Rosenblum continues describing the procedure, noting that the needle was advanced to the anterior border of T12-L1 under multiple imaging views. Contrast dye studies verified spread and location, with digital subtraction angiography used to check for intravascular uptake. A test dose of 1ml of 0.5% bupivacaine with epinephrine per site was administered, which Dr. Rosenblum finds interesting as he typically doesn't mix bupivacaine with epinephrine. After confirming no vascular uptake, 3-5ml of 6% aqueous phenol was injected in 1ml aliquots while communicating with the patient. The average procedure time was 16.3 minutes with minimal or no sedation. Patients remained prone for 30 minutes afterward to avoid neuroforaminal spread, as phenol is heavier and more viscous than alcohol. Post-Procedure Care and Study Evaluation Dr. Rosenblum explains that patients were monitored in recovery for one hour for adverse events and their ability to eat and void easily. They were discharged once hospital post-anesthetic criteria were met and received a follow-up call 24 hours later. Dr. Rosenblum praises the study and notes that the procedure looks similar to a lumbar sympathetic plexus block, which is also a sympathetic block. Ultrasound Considerations and Alternative Approaches Dr. Rosenblum shares his interest in ultrasound-guided celiac plexus blocks but acknowledges concerns about bowel perforation. He mentions a conversation with an interventional radiology colleague who suggested a transhepatic approach. Dr. Rosenblum recalls scanning a very thin patient where the aorta was easily visible and close to the anterior abdominal wall, making the celiac plexus potentially accessible if bowel perforation, liver bleeding, or gallbladder perforation could be avoided. He shares an experience with a patient suffering from severe pancreatitis pain who received temporary relief from a paravertebral thoracic nerve block at T8-T10, noting that paravertebral blocks provide some sympathetic spread. Conclusion and Community Resource Reminder Dr. Rosenblum concludes by recommending the article, noting its well-written analysis and graphs showing morphine consumption dropping over months following the procedure. He suggests neurolytic procedures are underutilized because they sound intimidating. He again encourages listeners to check out the community he created with separate chat rooms for regenerative medicine, regional anesthesia, and pain boards, where users can share keywords but not specific board questions. Dr. Rosenblum reminds listeners about upcoming courses and his website resources, mentions an upcoming PRP lecture, and asks for five-star reviews if listeners enjoy the podcast. The episode ends with a standard medical disclaimer. Reference https://www.painphysicianjournal.com/current/pdf?article=NTQwOA%3D%3D&journal=113

Crypto News: Ripple and Web3 Salon are launching a new partnership for Japan-based Web3 startups to build on the XRP Ledger. Deutsche Bank is exploring stablecoins and tokenized deposits as part of its digital assets strategy. Show Sponsor -

Yat Siu, Co-founder and Chairman of Animoca Brands, joined me to discuss how Web3 will transform the world and how businesses and individuals can adapt to this emerging technology. Topics:- Why people should care about Web3 - How Bitcoin fits in Web3 - How Businesses can use Web3 tech to improve customer retention - Sony's Blockchain - Web3 Gaming - Digital currency in the Space economy - Tokenized assets & NFTs Show Sponsor -

Crypto News: Uber CEO says they are looking at integrating stablecoins. Apple, X, Airbnb, Google are also exploring stablecoins. Gemini crypto exchange files for an IPO.Show Sponsor -

Brian from Santiment joined me to discuss the current state of the Crypto market. When will Bitcoin and altcoins such as XRP, Ethereum, and Solana see a reversal?

Crypto News: Bitcoin dumps as uncertainty with President Trump and Elon Musk rises. Circle goes public on the NYSE.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/

In this conversation, Camila Russo interviews Tomasz Stanczak, Co-Executive Director of the Ethereum Foundation, discussing the evolution of Ethereum, addressing criticisms, and the foundation's strategic initiatives. They explore the importance of communication, the restructuring of the foundation, and the focus on scaling Ethereum through L1 and L2 dynamics. Tomasz shares insights on the vision for Ethereum as a global economy, balancing user needs with core values, and the foundation's treasury management and DeFi strategies. The conversation concludes with a look at future developments and milestones for Ethereum.Takeaways:Ethereum has evolved significantly since its inception, focusing on scaling and communication.The Ethereum Foundation has faced criticism regarding its communication strategies.Restructuring within the foundation aims to enhance protocol development and management.Funding and support for developers are crucial for the ecosystem's growth.The relationship between L1 and L2 is vital for Ethereum's scaling strategy.Ethereum aims to position itself as a global economy hub.User needs and core values must be balanced for long-term success.Treasury management strategies are evolving to include DeFi protocols.The foundation is committed to transparency and community engagement.Future milestones include significant scaling and security improvements.Chapters:00:00 Defiant Intro00:07 Episode Teaser01:24 Hero Quote01:35 Introduction to Tomasz Stańczak, Co-Executive Director of the Ethereum Foundation03:18 Community Criticism and Foundation Response06:45 Strategic Actions by the Ethereum Foundation 09:39 Building a Supportive Ecosystem for Developers13:50 The strengths of Ethereum as a Network17:17 Scaling Ethereum: L1 and L2 Dynamics20:55 The One Trillion Security Initiative23:00 Specific Milestones in the Short Term25:53 Navigating the Tension: World Computer vs. Store of Value29:15 Ethereum as a Global Economy30:43 Will Solana Become An Ethereum L2?32:43 User Priorities: Decentralization vs. Usability37:02 Treasury Management and ETH Sales36:55 The Role of Stablecoins in Ethereum's Future39:55 The Impact of Ethereum Foundation's DeFi Allocations42:00 Guiding DeFi Protocols Towards Security and Decentralization51:10 The Future of Ethereum: Use Cases and Community Expectations54:50 Upcoming Milestones for Ethereum56:50 Closing Remarks

Sulolit Raj Mukherjee, Founder and CEO of Bodin Advisory, joined me to discuss his time at the IRS and how the IRS will handle crypto moving forward. https://bodin-advisory.com/Topics:- Raj's time in TradFi, Crypto, & at the IRS - IRS' approach to Crypto - IRS DeFi Broker Rule repealed - Upcoming Tax Docs for Crypto - Future of Crypto in the US Show Sponsor -

Crypto News: JP Morgan will offer clients loans on Bitcoin ETFs. California passes a new Bitcoin bill. Top holders of BTC & Ethereum ETFs revealed.Show Sponsor -

Crypto News: Lots of drama raises for Trump and crypto as a Trump Wallet is launched for the memecoin. Truth Social files for a Bitcoin ETF. Brad Garlinghouse says Ripple never made a bid to acquire Circle. Show Sponsor -

Send us a textOn today's episode, The crew met with a few local contractors from the Chicago area LIVE! at the Borinquen Restaurant in Chicago, Illinois to talk about voltages. We talked jabaritos, L1 and L2, and communication voltage in this episode, with some real world examples of the importance of these checks.Check out our youtube channel called the METUS Training Network.Thanks for listening! Please visit www.mitsubishicomfort.comContact us at metustechshow@hvac.mea.com

Crypto News: Robinhood completes Bitstamp crypto exchange acquisition. BitGo will custody Vivo Power's $100 Million XRP assets. Show Sponsor -

Gm and Happy Monday! This week, Dan Smith, a Lead Blockworks Researcher and Jonah Weinstein, a Portfolio Manager of SkyCatcher, join Jason to dive into the timely conversation about which metric is better/best to evaluate L1 tokens – REV or RSOV? Start your day with the Empire newsletter by Katherine Ross: https://blockworks.co/newsletter/empire?utm_source=podcasts Follow Santi: https://x.com/santiagoroel Follow Jason: https://x.com/JasonYanowitz Follow Empire: https://twitter.com/theempirepod Join the Empire Telegram: https://t.me/+CaCYvTOB4Eg1OWJh -- Grab your tickets to Permissionless IV. Use code EMPIRE10 for 10% off: https://blockworks.co/event/permissionless-iv -- SKALE is the next evolution in Layer 1 blockchains with a gas-free invisible user experience, instant finality, high speed, and robust security. SKALE is built different as it allows for limitless scalability and has already saved its 50 Million users over $11 Billion in gas fees. SKALE is high-performance and cost-effective, making it ideal for compute-intensive applications like AI, gaming, and consumer-facing dApps. Learn more at https://skale.space and stay up to date with the gas-free invisible blockchain on X at @skalenetwork -- Marinade Labs develops staking technologies that strengthen Solana.In 2021, our protocol was the first to bring liquid staking to the network; today, our sophisticated, high-performance staking delegation platform brings billions in liquidity and security to the SOL market. We have solutions for both DeFi and TradFi, including liquid and native staking, as well as direct enterprise integrations. Our best-in-market features include user downside protection (through protected staking rewards) and optimized delegation (via our automated auction marketplace). Cryptoasset investors worldwide, from individual traders to global institutions, use Marinade to earn rewards on their SOL treasuries and holdings. We are headquartered in New York, with offices in the European Union, including Prague. To learn more about Marinade, visit https://www.marinade.finance. -- Crypto never sleeps. So we built an Al analyst that never blinks. Meet Focal by FalconX: a GenAI insights engine built for institutional crypto. Already used by 80+ funds managing $10B+ in AUM.  - Screen, chart, and analyze 1300+ tokens - Summarize market-moving news instantly - Integrates data from CoinGecko, Kaito, Token Terminal, Tokenomist, The Tie Get started today: https://askfocal.com -- Ledn is the leading platform for Bitcoin-backed loans, offering a secure and transparent way to unlock liquidity without selling your Bitcoin. Ledn has issued over $9 billion in loans since 2018 and has never lost a single satoshi of client assets, earning a reputation as the name you can trust in the crypto space.Visit https://www.ledn.io to learn more. -- Chapters: 00:00 - Intro 02:31 - Why Do We Need Better Valuation Frameworks? 05:00 - What's Wrong With The Metrics Today? 08:07 - What's The Proper Reference Point To Understand Value? 09:33 - Are L1 Tokens Money? 11:10 - Ads (Skale Marinade) 12:48 - Is A L1 Token A Commodity Or Company? 19:32 - Why RSOV Valuation Is So Important 23:48 - Ads (Skale Marinade) 29:07 - Valuation Litmus Test 31:38 - RSOV & Capital Inflows 37:53 - What's REV? 42:58 - RSOV's Valuation Mechanism 44:43 - Where RSOV and REV differ 47:27 - If Native Assets 10X, Do The Hotspots? 49:05 - Ads (Falcon x, LEDN) 50:52 - Monetary L1 Premium Factor In? 55:36 - RSOV vs REV Valuation Trends Over Time 01:00:49 - How Does Staking / DeFi Deposits Impact Valuation? 01:02:47 - PE Values In RSOV 01:05:25 - Audience Question From Telegram — Disclaimer: Nothing said on Empire is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Santiago, Jason, and our guests may hold positions in the companies, funds, or projects discussed.

Crypto News: Bitcoin pullsback, what happens next for BTC and Altcoins. Elon Musk mentions Bitcoin with new XChat. Paul Krugman crypto fud.Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

Crypto News: Bitcoin pulls back , when will we see a major move for altcoins and he crypto market. Trump Media closed a $2.44 billion capital raise with funds planned to be used to create a bitcoin (BTC) treasury.Show Sponsor -

Sid Powell, CEO and Co-Founder of Maple Finance, joined me to discuss Cantor Fitzgerald's $2 Billion Bitcoin lending program and how Maple Finance is participating.Topics:- Maple Finance overview - Institutional DeFi - Maple's Hybrid DeFi service - Cantor Fitzgerald's Bitcoin Lending - Bitcoin as a Reserve asset - US Crypto Outlook Show Sponsor -

Crypto News: Two new companies are going to buy Millions in XRP for treasury reserve. Congress introduces CLARITY Act, a bipartisan bill which would establish a regulatory framework for digital assets in the US. SEC gives clarity on staking and drops Binance case.Show Sponsor -

Crypto News: VivoPower International will create XRP Treasury. Bergen County, NJ plans to tokenize all property deeds on the Avalanche network. US Labor Department rescinds guidance against Crypto in 401(k) Plans. Pakistan to launch Strategic Bitcoin Reserve.Show Sponsor -

Crypto News: Circle files with NYSE for IPO. Trump Media raising $2.5 billion for Bitcoin treasury. Cantor Fitzgerald officially kicked off a $2 billion Bitcoin-backed lending program with financing deals for FalconX and Maple Finance. SharpLink launches Ethereum treasury. Show Sponsor - ✅ VeChain is a versatile enterprise-grade L1 smart contract platform https://www.vechain.org/ 

How should we value L1 tokens in crypto? Today's guest, Jonah Weinstein of Skycatcher, introduces RSOV—“Realized Store of Value”—a new metric designed to fundamentally rethink how we evaluate Layer 1 assets like ETH, SOL, and BTC. In this episode, we explore why traditional models like DCF and REV fall short for monetary assets, how RSOV works, and why it may be a better way to understand crypto's total addressable market. Tune in for a fresh perspective that could change how you analyze L1s forever. ------