Podcasts about Anthropogeny

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  • 1,572EPISODES
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    Best podcasts about Anthropogeny

    Latest podcast episodes about Anthropogeny

    Science (Video)
    CARTA: Mismatch: Human Origins and Modern Disease - Questions Answers and Closing Remarks

    Science (Video)

    Play Episode Listen Later Jul 6, 2025 75:35


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40702]

    Science (Video)
    CARTA: The Industrialized Gut Microbiome with Justin and Erica Sonnenberg

    Science (Video)

    Play Episode Listen Later Jun 27, 2025 19:43


    The human gut microbiome is tightly linked our health. Our analyses of diverse human populations from around the globe, ranging from hunter-gatherer to industrialized, show that the gut microbiome is profoundly influenced by lifestyle. With a large collaborative team, we conducted deep metagenomic sequencing of the gut microbiomes of Tsimane horticulturalists from Bolivia and compared them to those of Hadza hunter-gatherers from Tanzania. We are also investigating whether diet and microbial therapies can address deficiencies in the industrialized gut community. Molecular mechanisms of host-microbial interaction are pursued using an array of technologies and experimental approaches including gnotobiotic and conventional mouse models, quantitative imaging, and a metabolomics pipeline focused on investigating microbiota-dependent metabolites. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40698]

    Science (Video)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    Science (Video)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    University of California Audio Podcasts (Audio)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    Humanities (Audio)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    Humanities (Audio)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    Science (Audio)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    Science (Audio)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    UC San Diego (Audio)
    CARTA: Biocultural Reproduction: The Human Style of Hyper-cooperation with Barry Bogin

    UC San Diego (Audio)

    Play Episode Listen Later Jun 23, 2025 17:57


    The essence of Being Human is the practice of Biocultural Reproduction (BCR). BCR is defined as the set of marriage and kinship based rules for extra-maternal cooperation in the production, feeding, and care of offspring. Human evolution theory needs to explain how people successfully combined a vastly extended period of offspring dependency and delayed reproduction with helpless newborns — with large heads and much body fat (even with problems giving birth) -- a short duration of breast-feeding, an adolescent growth spurt, and vigorous post-menopause valuable grandmothers. Are these characteristics a package or a mosaic? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40697]

    Science (Video)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    Science (Video)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    University of California Audio Podcasts (Audio)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    Humanities (Audio)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    Humanities (Audio)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    Science (Audio)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    Science (Audio)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    UC San Diego (Audio)
    CARTA: Does the Placenta Drive the Evolution of Cancer Malignancy with Günter Wagner

    UC San Diego (Audio)

    Play Episode Listen Later Jun 13, 2025 19:38


    The rate of cancer and cancer malignancy differ greatly among mammalian species. The placental – maternal interface is also highly variable between placental mammals. This lecture will discuss recent advances that suggest that there is a causal connection between the evolution of placental biology and the biology and rate of cancer malignancy. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40694]

    Science (Video)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    Science (Video)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    University of California Audio Podcasts (Audio)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    Humanities (Audio)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    Humanities (Audio)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    Science (Audio)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    Science (Audio)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    UC San Diego (Audio)
    CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera

    UC San Diego (Audio)

    Play Episode Listen Later Jun 9, 2025 24:17


    Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40693]

    Science (Video)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    Science (Video)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    Science (Video)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    Science (Video)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    University of California Audio Podcasts (Audio)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    University of California Audio Podcasts (Audio)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    Humanities (Audio)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    Humanities (Audio)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    Humanities (Audio)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    Humanities (Audio)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    Science (Audio)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    Science (Audio)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    Science (Audio)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    Science (Audio)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    UC San Diego (Audio)
    CARTA: Mismatch: Human Origins and Modern Disease - Welcome and Opening Remarks

    UC San Diego (Audio)

    Play Episode Listen Later May 28, 2025 7:52


    The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40701]

    UC San Diego (Audio)
    CARTA: Cancer is Normal Development Spun Out of Control with Steve Frank

    UC San Diego (Audio)

    Play Episode Listen Later May 28, 2025 16:47


    Cancer is normal development spun out of control. It is the great plasticity and power of development, without the overarching controls that guide normal development toward an integrated adult form. Instead, whenever a newly developed kind of tissue acquires the ability to survive, grow, and resist control, there is nothing to stop it. That may be why normal adult cells are often terminally differentiated into a restricted cellular program. And it may be why wound healing, which releases the restricted cellular program and powerfully plastic tissue remodeling, is so tightly regulated and, when dysregulated, so often associates with cancer. With regard to evolutionary history, humans develop differently from their ape ancestors, and their lifestyle causes them to suffer different kinds of tissue damage. Those differences in development and wound healing likely led to new aspects of cancer disease over human history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40691]

    Science (Video)
    CARTA: Origins of Love - Questions Answers and Closing Remarks

    Science (Video)

    Play Episode Listen Later Mar 29, 2025 68:58


    Human beings show a range of emotional attachment, affection, and infatuation often referred to as “love”. Love promotes long-lasting and secure relationships that involve nurturing and support. Biological mechanisms underlying such behavior involve ancient neuropeptides and their receptors in the brain. These systems are also involved in reproduction, ranging from mating and pair-bonding, to giving birth and lactation. They shape the earliest experiences of all mammals and their mothers. The concept of love and how we experience it are affected by culture and its diverse societal norms. This symposium will explore the evolutionary roots of human love, compare human love to corresponding emotions in other animals, consider human conditions that prevent the expression of such feelings, and examine the key role of love and affection for our development and daily lives.  Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40506]

    University of California Audio Podcasts (Audio)
    CARTA: Origins of Love - Questions Answers and Closing Remarks

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Mar 29, 2025 68:58


    Human beings show a range of emotional attachment, affection, and infatuation often referred to as “love”. Love promotes long-lasting and secure relationships that involve nurturing and support. Biological mechanisms underlying such behavior involve ancient neuropeptides and their receptors in the brain. These systems are also involved in reproduction, ranging from mating and pair-bonding, to giving birth and lactation. They shape the earliest experiences of all mammals and their mothers. The concept of love and how we experience it are affected by culture and its diverse societal norms. This symposium will explore the evolutionary roots of human love, compare human love to corresponding emotions in other animals, consider human conditions that prevent the expression of such feelings, and examine the key role of love and affection for our development and daily lives.  Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40506]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Origins of Love - Questions Answers and Closing Remarks

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Mar 29, 2025 68:58


    Human beings show a range of emotional attachment, affection, and infatuation often referred to as “love”. Love promotes long-lasting and secure relationships that involve nurturing and support. Biological mechanisms underlying such behavior involve ancient neuropeptides and their receptors in the brain. These systems are also involved in reproduction, ranging from mating and pair-bonding, to giving birth and lactation. They shape the earliest experiences of all mammals and their mothers. The concept of love and how we experience it are affected by culture and its diverse societal norms. This symposium will explore the evolutionary roots of human love, compare human love to corresponding emotions in other animals, consider human conditions that prevent the expression of such feelings, and examine the key role of love and affection for our development and daily lives.  Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40506]

    Humanities (Audio)
    CARTA: Origins of Love - Questions Answers and Closing Remarks

    Humanities (Audio)

    Play Episode Listen Later Mar 29, 2025 68:58


    Human beings show a range of emotional attachment, affection, and infatuation often referred to as “love”. Love promotes long-lasting and secure relationships that involve nurturing and support. Biological mechanisms underlying such behavior involve ancient neuropeptides and their receptors in the brain. These systems are also involved in reproduction, ranging from mating and pair-bonding, to giving birth and lactation. They shape the earliest experiences of all mammals and their mothers. The concept of love and how we experience it are affected by culture and its diverse societal norms. This symposium will explore the evolutionary roots of human love, compare human love to corresponding emotions in other animals, consider human conditions that prevent the expression of such feelings, and examine the key role of love and affection for our development and daily lives.  Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40506]

    Science (Audio)
    CARTA: Origins of Love - Questions Answers and Closing Remarks

    Science (Audio)

    Play Episode Listen Later Mar 29, 2025 68:58


    Human beings show a range of emotional attachment, affection, and infatuation often referred to as “love”. Love promotes long-lasting and secure relationships that involve nurturing and support. Biological mechanisms underlying such behavior involve ancient neuropeptides and their receptors in the brain. These systems are also involved in reproduction, ranging from mating and pair-bonding, to giving birth and lactation. They shape the earliest experiences of all mammals and their mothers. The concept of love and how we experience it are affected by culture and its diverse societal norms. This symposium will explore the evolutionary roots of human love, compare human love to corresponding emotions in other animals, consider human conditions that prevent the expression of such feelings, and examine the key role of love and affection for our development and daily lives.  Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40506]

    Science (Video)
    CARTA: The Biology of Fatherhood in Humans: Evolutionary Origins and Cross-Cultural Perspectives with Lee Gettler

    Science (Video)

    Play Episode Listen Later Mar 28, 2025 23:13


    Human fathers exhibit hormonal shifts in testosterone, prolactin, and oxytocin, enabling flexible responses to parenting. In species with costly paternal care, these shifts balance mating and parenting efforts, suggesting evolved neuroendocrine capacities that support fatherhood. Today, fathers collaborate with mothers worldwide, though their roles vary across cultures and family systems, much as they likely did evolutionarily. Using research from the Philippines, Congo-Brazzaville, and the U.S., alongside cross-cultural data, this talk examines how men's hormonal physiology adapts to parenthood and influences family behaviors and bonds within diverse ecological and cultural contexts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40387]

    University of California Audio Podcasts (Audio)
    CARTA: The Biology of Fatherhood in Humans: Evolutionary Origins and Cross-Cultural Perspectives with Lee Gettler

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Mar 28, 2025 23:13


    Human fathers exhibit hormonal shifts in testosterone, prolactin, and oxytocin, enabling flexible responses to parenting. In species with costly paternal care, these shifts balance mating and parenting efforts, suggesting evolved neuroendocrine capacities that support fatherhood. Today, fathers collaborate with mothers worldwide, though their roles vary across cultures and family systems, much as they likely did evolutionarily. Using research from the Philippines, Congo-Brazzaville, and the U.S., alongside cross-cultural data, this talk examines how men's hormonal physiology adapts to parenthood and influences family behaviors and bonds within diverse ecological and cultural contexts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40387]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: The Biology of Fatherhood in Humans: Evolutionary Origins and Cross-Cultural Perspectives with Lee Gettler

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Mar 28, 2025 23:13


    Human fathers exhibit hormonal shifts in testosterone, prolactin, and oxytocin, enabling flexible responses to parenting. In species with costly paternal care, these shifts balance mating and parenting efforts, suggesting evolved neuroendocrine capacities that support fatherhood. Today, fathers collaborate with mothers worldwide, though their roles vary across cultures and family systems, much as they likely did evolutionarily. Using research from the Philippines, Congo-Brazzaville, and the U.S., alongside cross-cultural data, this talk examines how men's hormonal physiology adapts to parenthood and influences family behaviors and bonds within diverse ecological and cultural contexts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40387]

    Humanities (Audio)
    CARTA: The Biology of Fatherhood in Humans: Evolutionary Origins and Cross-Cultural Perspectives with Lee Gettler

    Humanities (Audio)

    Play Episode Listen Later Mar 28, 2025 23:13


    Human fathers exhibit hormonal shifts in testosterone, prolactin, and oxytocin, enabling flexible responses to parenting. In species with costly paternal care, these shifts balance mating and parenting efforts, suggesting evolved neuroendocrine capacities that support fatherhood. Today, fathers collaborate with mothers worldwide, though their roles vary across cultures and family systems, much as they likely did evolutionarily. Using research from the Philippines, Congo-Brazzaville, and the U.S., alongside cross-cultural data, this talk examines how men's hormonal physiology adapts to parenthood and influences family behaviors and bonds within diverse ecological and cultural contexts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40387]

    Science (Audio)
    CARTA: The Biology of Fatherhood in Humans: Evolutionary Origins and Cross-Cultural Perspectives with Lee Gettler

    Science (Audio)

    Play Episode Listen Later Mar 28, 2025 23:13


    Human fathers exhibit hormonal shifts in testosterone, prolactin, and oxytocin, enabling flexible responses to parenting. In species with costly paternal care, these shifts balance mating and parenting efforts, suggesting evolved neuroendocrine capacities that support fatherhood. Today, fathers collaborate with mothers worldwide, though their roles vary across cultures and family systems, much as they likely did evolutionarily. Using research from the Philippines, Congo-Brazzaville, and the U.S., alongside cross-cultural data, this talk examines how men's hormonal physiology adapts to parenthood and influences family behaviors and bonds within diverse ecological and cultural contexts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40387]

    Science (Video)
    CARTA: Love Monogamy and Fatherhood in Latin American Monkeys with Eduardo Fernandez-Duque

    Science (Video)

    Play Episode Listen Later Mar 24, 2025 18:25


    The titi and owl monkeys of South America live in socially-monogamous groups where the male and female establish a pair bond and share parental duties. Why do males of these species mate in a monogamous relationship presumably foregoing other reproductive opportunities? And why are titi and owl monkey males such good fathers, investing heavily in the care of offspring that they cannot be certain they sired? Relying on ecological, behavioral and genetic data collected during 28 years from wild populations in Argentina, Peru and Ecuador. This lecture will discuss the role of food distribution, mate guarding and infant care in the evolution of pair-bonds, monogamy and paternal care. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40382]

    University of California Audio Podcasts (Audio)
    CARTA: Love Monogamy and Fatherhood in Latin American Monkeys with Eduardo Fernandez-Duque

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Mar 24, 2025 18:25


    The titi and owl monkeys of South America live in socially-monogamous groups where the male and female establish a pair bond and share parental duties. Why do males of these species mate in a monogamous relationship presumably foregoing other reproductive opportunities? And why are titi and owl monkey males such good fathers, investing heavily in the care of offspring that they cannot be certain they sired? Relying on ecological, behavioral and genetic data collected during 28 years from wild populations in Argentina, Peru and Ecuador. This lecture will discuss the role of food distribution, mate guarding and infant care in the evolution of pair-bonds, monogamy and paternal care. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40382]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: Love Monogamy and Fatherhood in Latin American Monkeys with Eduardo Fernandez-Duque

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Mar 24, 2025 18:25


    The titi and owl monkeys of South America live in socially-monogamous groups where the male and female establish a pair bond and share parental duties. Why do males of these species mate in a monogamous relationship presumably foregoing other reproductive opportunities? And why are titi and owl monkey males such good fathers, investing heavily in the care of offspring that they cannot be certain they sired? Relying on ecological, behavioral and genetic data collected during 28 years from wild populations in Argentina, Peru and Ecuador. This lecture will discuss the role of food distribution, mate guarding and infant care in the evolution of pair-bonds, monogamy and paternal care. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40382]

    Humanities (Audio)
    CARTA: Love Monogamy and Fatherhood in Latin American Monkeys with Eduardo Fernandez-Duque

    Humanities (Audio)

    Play Episode Listen Later Mar 24, 2025 18:25


    The titi and owl monkeys of South America live in socially-monogamous groups where the male and female establish a pair bond and share parental duties. Why do males of these species mate in a monogamous relationship presumably foregoing other reproductive opportunities? And why are titi and owl monkey males such good fathers, investing heavily in the care of offspring that they cannot be certain they sired? Relying on ecological, behavioral and genetic data collected during 28 years from wild populations in Argentina, Peru and Ecuador. This lecture will discuss the role of food distribution, mate guarding and infant care in the evolution of pair-bonds, monogamy and paternal care. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40382]

    Science (Audio)
    CARTA: Love Monogamy and Fatherhood in Latin American Monkeys with Eduardo Fernandez-Duque

    Science (Audio)

    Play Episode Listen Later Mar 24, 2025 18:25


    The titi and owl monkeys of South America live in socially-monogamous groups where the male and female establish a pair bond and share parental duties. Why do males of these species mate in a monogamous relationship presumably foregoing other reproductive opportunities? And why are titi and owl monkey males such good fathers, investing heavily in the care of offspring that they cannot be certain they sired? Relying on ecological, behavioral and genetic data collected during 28 years from wild populations in Argentina, Peru and Ecuador. This lecture will discuss the role of food distribution, mate guarding and infant care in the evolution of pair-bonds, monogamy and paternal care. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40382]

    Science (Video)
    CARTA: The Biology of Grandmaternal Love with James Rilling

    Science (Video)

    Play Episode Listen Later Mar 10, 2025 17:17


    Grandmothers play a key role as alloparents in human families. A leading hypothesis suggests that the inclusive fitness benefits of grandmaternal care selected for an extended female lifespan after reproduction, a unique trait among primates. Beyond lifespan extension, grandmothers may have biological adaptations for caregiving. Research from our lab shows grandmothers have lower DNA methylation of the oxytocin receptor gene (OXTR) compared to non-grandmothers, with lower methylation linked to stronger bonds with grandchildren. MRI scans reveal grandmothers have a lower brain age than controls, further reduced among those with higher engagement. These findings suggest grandmotherhood may enhance oxytocin signaling, promoting bonding and slowing brain aging. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40383]

    University of California Audio Podcasts (Audio)
    CARTA: The Biology of Grandmaternal Love with James Rilling

    University of California Audio Podcasts (Audio)

    Play Episode Listen Later Mar 10, 2025 17:17


    Grandmothers play a key role as alloparents in human families. A leading hypothesis suggests that the inclusive fitness benefits of grandmaternal care selected for an extended female lifespan after reproduction, a unique trait among primates. Beyond lifespan extension, grandmothers may have biological adaptations for caregiving. Research from our lab shows grandmothers have lower DNA methylation of the oxytocin receptor gene (OXTR) compared to non-grandmothers, with lower methylation linked to stronger bonds with grandchildren. MRI scans reveal grandmothers have a lower brain age than controls, further reduced among those with higher engagement. These findings suggest grandmotherhood may enhance oxytocin signaling, promoting bonding and slowing brain aging. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40383]

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)
    CARTA: The Biology of Grandmaternal Love with James Rilling

    CARTA - Center for Academic Research and Training in Anthropogeny (Video)

    Play Episode Listen Later Mar 10, 2025 17:17


    Grandmothers play a key role as alloparents in human families. A leading hypothesis suggests that the inclusive fitness benefits of grandmaternal care selected for an extended female lifespan after reproduction, a unique trait among primates. Beyond lifespan extension, grandmothers may have biological adaptations for caregiving. Research from our lab shows grandmothers have lower DNA methylation of the oxytocin receptor gene (OXTR) compared to non-grandmothers, with lower methylation linked to stronger bonds with grandchildren. MRI scans reveal grandmothers have a lower brain age than controls, further reduced among those with higher engagement. These findings suggest grandmotherhood may enhance oxytocin signaling, promoting bonding and slowing brain aging. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40383]