Podcasts about PLOS

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-435 Overview: In this episode, we discuss how screen time—from adolescence through adulthood—can disrupt sleep more than we might realize. Hear what the latest research says about topics like blue light and sleep duration, discover practical strategies to sleep smarter in this digital world, and learn how sleep deprivation can impact the health of your patients. Episode resource links: Zhong, C., Masters, M., Donzella, S. M., Diver, W. R., & Patel, A. V. (2025). Electronic Screen Use and Sleep Duration and Timing in Adults. JAMA Network Open, 8(3), e252493-e252493. Liu, Y. (2016). Prevalence of healthy sleep duration among adults—United States, 2014. MMWR. Morbidity and mortality weekly report, 65. Centers for Disease Control and Prevention (CDC). (2017). Announcement: sleep awareness week, April 23–29, 2017. Morb Mortal Wkly Rep (MMWR), 66(15), 411. Chaput, J. P., Dutil, C., Featherstone, R., Ross, R., Giangregorio, L., Saunders, T. J., ... & Carrier, J. (2020). Sleep duration and health in adults: an overview of systematic reviews. Applied Physiology, Nutrition, and Metabolism, 45(10), S218-S231. Hartley, S., Royant-Parola, S., Zayoud, A., Gremy, I., & Matulonga, B. (2022). Do both timing and duration of screen use affect sleep patterns in adolescents?. Plos one, 17(10), e0276226. Salfi, F., Amicucci, G., Corigliano, D., D'Atri, A., Viselli, L., Tempesta, D., & Ferrara, M. (2021). Changes of evening exposure to electronic devices during the COVID-19 lockdown affect the time course of sleep disturbances. Sleep, 44(9), zsab080. He, J. W., Tu, Z. H., Xiao, L., Su, T., & Tang, Y. X. (2020). Effect of restricting bedtime mobile phone use on sleep, arousal, mood, and working memory: a randomized pilot trial. PloS one, 15(2), e0228756. Guest: Mariyan L. Montaque, DNP, FNP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-435 Overview: In this episode, we discuss how screen time—from adolescence through adulthood—can disrupt sleep more than we might realize. Hear what the latest research says about topics like blue light and sleep duration, discover practical strategies to sleep smarter in this digital world, and learn how sleep deprivation can impact the health of your patients. Episode resource links: Zhong, C., Masters, M., Donzella, S. M., Diver, W. R., & Patel, A. V. (2025). Electronic Screen Use and Sleep Duration and Timing in Adults. JAMA Network Open, 8(3), e252493-e252493. Liu, Y. (2016). Prevalence of healthy sleep duration among adults—United States, 2014. MMWR. Morbidity and mortality weekly report, 65. Centers for Disease Control and Prevention (CDC). (2017). Announcement: sleep awareness week, April 23–29, 2017. Morb Mortal Wkly Rep (MMWR), 66(15), 411. Chaput, J. P., Dutil, C., Featherstone, R., Ross, R., Giangregorio, L., Saunders, T. J., ... & Carrier, J. (2020). Sleep duration and health in adults: an overview of systematic reviews. Applied Physiology, Nutrition, and Metabolism, 45(10), S218-S231. Hartley, S., Royant-Parola, S., Zayoud, A., Gremy, I., & Matulonga, B. (2022). Do both timing and duration of screen use affect sleep patterns in adolescents?. Plos one, 17(10), e0276226. Salfi, F., Amicucci, G., Corigliano, D., D'Atri, A., Viselli, L., Tempesta, D., & Ferrara, M. (2021). Changes of evening exposure to electronic devices during the COVID-19 lockdown affect the time course of sleep disturbances. Sleep, 44(9), zsab080. He, J. W., Tu, Z. H., Xiao, L., Su, T., & Tang, Y. X. (2020). Effect of restricting bedtime mobile phone use on sleep, arousal, mood, and working memory: a randomized pilot trial. PloS one, 15(2), e0228756. Guest: Mariyan L. Montaque, DNP, FNP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Let's go deeper into how to actually foster psychological safety in teams—not just what it is, but how to spot it, build it, and fix it.  In this Episode: Dr. Heather Morton, Tom Bradshaw, Dr. Juliette Nelson, Dr. Emi Barresi, Dr. Pamela Maurer, Lee Crowson, Rich Cruz, LindaAnn Rogers, Nic Krueger,   I/O Career Accelerator Course: https://www.seboc.com/job Visit us https://www.seboc.com/ Follow us on LinkedIn: https://bit.ly/sebocLI Join an open-mic event: https://www.seboc.com/events   References: Hoshina, Y., Shikino, K., Yamauchi, Y., Yanagita, Y., Yokokawa, D., Tsukamoto, T., ... & Ikusaka, M. (2021). Does a learner-centered approach using teleconference improve medical students' psychological safety and self-explanation in clinical reasoning conferences? a crossover study. Plos one, 16(7), e0253884.     Smith, E. V. (2025, March 17). Research 2024 - Elizabeth Vahey Smith. Elizabeth Vahey Smith.  https://elizabethvaheysmith.com/research-2024-survey/     Wang, C., & Ning, Y. (2024). The employee's perception of psychological safety: construct dimensions, scale development and validation. BMC psychology, 12(1), 770. 

Wir besitzen Meinungsfreiheit, haben frei von der Arbeit oder leben schmerzfrei - Freiheit scheint in jeglicher Hinsicht erstrebenswert. Doch was genau ist Freiheit überhaupt? Sinja und Boris versuchen in dieser Folge "Freiheit" philosophisch greifbar zu machen. Anschließend zeigen sie dir verschiedene Wege auf, mit Achtsamkeit und Meditation Freiheit erfahrbar zu machen.Umfrage: Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns ⁠hier⁠. Hintergründe und Studien:Brewer, J. A., Mallik, S., Babuscio, T. A., Nich, C., Johnson, H. E., Deleone, C. M., ... & Rounsaville, B. J. (2011). Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug and alcohol dependence, 119(1-2), 72-80. Link zur StudieSumantry, D., & Stewart, K. E. (2021). Meditation, mindfulness, and attention: A meta-analysis. Mindfulness, 12, 1332-1349. Link zur Studie Cortés Pascual, A., Moyano Muñoz, N., & Quílez Robres, A. (2019). The relationship between executive functions and academic performance in primary education: Review and meta-analysis. Frontiers in psychology, 10, 449759. Link zur Studie Bashir, K., Edstrom, S. B., Barlow, S. J., Gainer, D., & Lewis, J. D. (2025). Loving‐Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long‐Term Practitioners and Clinical Implications. Brain and Behavior, 15(3), e70372. Link zur Studie Almahayni, O., & Hammond, L. (2024). Does the Wim Hof Method have a beneficial impact on physiological and psychological outcomes in healthy and non-healthy participants? A systematic review. Plos one, 19(3), e0286933. Link zur Studie Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M., & Davidson, R. J. (2004). Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the national Academy of Sciences, 101(46), 16369-16373. Link zur Studie Mehr zum Thema WOOP: Hier Relevante philosophische Werke:Martin Buber – Ich und Du (1923), Gütersloher Verlagshaus Emmanuel Levinas – Totalität und Unendlichkeit (1961), Klostermann Verlag Hannah Arendt – Vita activa oder Vom tätigen Leben (1958), Piper Verlag Paul Tillich – Der Mut zum Sein (1952), Evangelisches Verlagswerk / später HarperOne Thich Nhat Hanh – Interbeing: Fourteen Guidelines for Engaged Buddhism (1987), Parallax Press

Bernhard Plos spielt Bass- und Kontrabassposaune.  Sein musikalisches Hauptaugenmerk liegt momentan bei der Synchron Stage in Wien, wo er regelmässig Movie Soundtracks, Trailer, Jingles und Aufnahmen aller Art einspielt. Diese Episode ist ein wahrer Ohrenschmaus für Low Brass Equipment Geeks und Alle, die es noch werden wollen.

Die Hälfte der Menschheit hat keinen Zugang zu sicherer, sauberer Sanitärversorgung. Doch Wasserklosetts sind nicht die Lösung. Wie also müssen wir umdenken?  Unsere Autorin Lena Bodewein hat als Korrespondentin in Südostasien an vielen Orten gesehen, was für Auswirkungen eine mangelnde Sanitärversorgung hat: Ohne Toiletten können sich Infektionskrankheiten verbreiten - 800 Kinder unter fünf Jahren sterben täglich an Durchfallerkrankungen. Aber auch Antibiotikaresistenzen spielen eine Rolle, Frauen sind mehr Gewaltverbrechen ausgesetzt, Mädchen gehen oft nicht zur Schule. Im Gespräch mit Host Lucie Kluth erklärt Lena, warum Forschende sich mit dem Problem auch kulturell beschäftigen und was für ungewohnte Lösungsansätze es gibt. Denn unser Abwasserkonzept lässt sich nicht einfach auf den globalen Süden übertragen, viel zu viel Trinkwasser wird dabei vergeudet. Die Recherche für diesen Podcast führt uns an Orte, die besser riechen als gedacht, zu Technologien, die Namen von Popstars tragen - und Unternehmern, die Kalauer lieben.  HINTERGRUNDINFORMATIONEN: 1. Pickering, Amy J et al.: Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial
The Lancet Global Health, Volume 3, Issue 11, e701 - e711. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(15)00144-8/fulltext 2. Sharma Waddington H, Masset E, Bick S, Cairncross S.: Impact on childhood mortality of interventions to improve drinking water, sanitation, and hygiene (WASH) to households: Systematic review and meta-analysis. PLoS medicine. 2023 Apr 20;20(4): e1004215. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004215 3. Cameron L, Olivia B S, Shah M.: Scaling up Sanitation: Evidence from an RCT in Indonesia. Journal of Development Economics 138(2019)1–16. https://www.sciencedirect.com/science/article/pii/S0304387818316298 4. Orgill-Meyer J, Pattanayak SK: Improved sanitation increases long-term cognitive test scores. World Development. 2020 Aug 1;132:104975. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3418412 5. Studie der German Toilet Organization über deutsche Schultoiletten: https://media.germantoilet.org/pages/schulen/toiletten-machen-schule-studie/2242471965-1692953784/tms_studie_2022-2023.pdf 6. Gu, Y., Zhou, W., Zheng, T. et al.: Health effects and externalities of the popularization of sanitary toilets: evidence from Rural China. BMC Public Health23, 2225 (2023). https://doi.org/10.1186/s12889-023-17192-4 7. Nunbogu AM, Elliott SJ: Characterizing gender-based violence in the context of water, sanitation, and hygiene: A scoping review of evidence in low-and middle-income countries. Water Security. 2022 Apr 1;15:100113. https://www.sciencedirect.com/science/article/abs/pii/S2468312422000049?via%3Dihub Mehr Wissenschaft bei NDR Info: https://www.ndr.de/nachrichten/info/sendungen/wissenschaft-und-bildung/index.html

Die Hälfte der Menschheit hat keinen Zugang zu sicherer, sauberer Sanitärversorgung. Doch Wasserklosetts sind nicht die Lösung. Wie also müssen wir umdenken?  Unsere Autorin Lena Bodewein hat als Korrespondentin in Südostasien an vielen Orten gesehen, was für Auswirkungen eine mangelnde Sanitärversorgung hat: Ohne Toiletten können sich Infektionskrankheiten verbreiten - 800 Kinder unter fünf Jahren sterben täglich an Durchfallerkrankungen. Aber auch Antibiotikaresistenzen spielen eine Rolle, Frauen sind mehr Gewaltverbrechen ausgesetzt, Mädchen gehen oft nicht zur Schule. Im Gespräch mit Host Lucie Kluth erklärt Lena, warum Forschende sich mit dem Problem auch kulturell beschäftigen und was für ungewohnte Lösungsansätze es gibt. Denn unser Abwasserkonzept lässt sich nicht einfach auf den globalen Süden übertragen, viel zu viel Trinkwasser wird dabei vergeudet. Die Recherche für diesen Podcast führt uns an Orte, die besser riechen als gedacht, zu Technologien, die Namen von Popstars tragen - und Unternehmern, die Kalauer lieben.  HINTERGRUNDINFORMATIONEN: 1. Pickering, Amy J et al.: Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial
The Lancet Global Health, Volume 3, Issue 11, e701 - e711. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(15)00144-8/fulltext 2. Sharma Waddington H, Masset E, Bick S, Cairncross S.: Impact on childhood mortality of interventions to improve drinking water, sanitation, and hygiene (WASH) to households: Systematic review and meta-analysis. PLoS medicine. 2023 Apr 20;20(4): e1004215. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004215 3. Cameron L, Olivia B S, Shah M.: Scaling up Sanitation: Evidence from an RCT in Indonesia. Journal of Development Economics 138(2019)1–16. https://www.sciencedirect.com/science/article/pii/S0304387818316298 4. Orgill-Meyer J, Pattanayak SK: Improved sanitation increases long-term cognitive test scores. World Development. 2020 Aug 1;132:104975. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3418412 5. Studie der German Toilet Organization über deutsche Schultoiletten: https://media.germantoilet.org/pages/schulen/toiletten-machen-schule-studie/2242471965-1692953784/tms_studie_2022-2023.pdf 6. Gu, Y., Zhou, W., Zheng, T. et al.: Health effects and externalities of the popularization of sanitary toilets: evidence from Rural China. BMC Public Health23, 2225 (2023). https://doi.org/10.1186/s12889-023-17192-4 7. Nunbogu AM, Elliott SJ: Characterizing gender-based violence in the context of water, sanitation, and hygiene: A scoping review of evidence in low-and middle-income countries. Water Security. 2022 Apr 1;15:100113. https://www.sciencedirect.com/science/article/abs/pii/S2468312422000049?via%3Dihub Mehr Wissenschaft bei NDR Info: https://www.ndr.de/nachrichten/info/sendungen/wissenschaft-und-bildung/index.html

Uwielbiam, kiedy pojawia się śmiały klient, rzuca wyzwanie i… udaje się to połączyć z psychoedukacją! I tu, moim zupełnie nieskromnym zdaniem, połączenie interesujące.Otóż…Przygotowujecie się na czarną godzinę? Trzymacie oszczędności? Wierzycie, że lepiej przygotować się na najgorsze, żeby pozytywnie się zaskoczyć?A co gdyby odwrócić narrację i przygotować się do realizacji… BIAŁYCH GODZIN?W tym odcinku wraz z @ingpolska rozpracowujemy ciasne sidła zachowań zabezpieczających: co tracimy szykując się na najgorsze, czy naprawdę nas to zabezpiecza, ile napięcia i czasu przepalamy na budowanie katastroficznych scenariuszy w głowie i czy są one gwarantem bezpieczeństwa, a także jak budować i realizować cele, plany i marzenia solo, w grupie lub na rzecz innych. A temat bierze się z akcji organizowanej przez patrona, czyli ING. ING Bank Śląski zachęca do tworzenia pozytywnych postanowień, które chce się realizować i odkładania na tzw. białą godzinę. W ramach akcji ING  zachęcał Polaków do zgłaszania swoich postanowień związanych z białą godziną i ciekawym przeżyciem z bliską osobą, które później zostały wyświetlone na ekranach multimedialnych w największych miastach Polski. Postanowienia zostały już wysłane, kilku z nich tutaj się przyjrzymy, ale Wy możecie samodzielnie zastanowić się nad tym co i dlaczego powstrzymuje Was przed przekłuciem swoich białych godzin w czyn. GROMKIE brawa dla partnera, a Was zapraszam do wysłuchania odcinka.Montaż: Eugeniusz KarlovLiteratura:DeHart, W. B., Friedel, J. E., Lown, J. M., & Odum, A. L. (2016). The Effects of Financial Education on Impulsive Decision Making. PloS one, 11(7), e0159561. https://doi.org/10.1371/journal.pone.0159561Gut, A., Miciuk, Ł., Gorbaniuk, O., Gut, P., & Karczmarczyk, A. (2021). Cultural management of terror and worry during the COVID-19 pandemic: How religiosity and a dream of human solidarity help the Polish people cope. Frontiers in Psychology, 12, 790333. https://doi.org/10.3389/fpsyg.2021.790333Friedline, T., Elliott, W., & Chowa, G. A. N. (2013). Testing an asset-building approach for young people: Early access to savings predicts later savings. Economics of Education Review, 33, 31–51. https://doi.org/10.1016/j.econedurev.2012.10.004

A large trial in cardiac pacing finally published, PVCs and cardiomyopathy, cannabis, CV risk and the danger of observational studies, and the tale of two disparate statin trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I BioPace Trial Trial manuscript https://doi.org/10.1093/europace/euaf029 II Another Belief Challenged in EP this week—PVCs and CM ‘ UC Paper https://doi.org/10.1016/j.jacep.2025.01.004 JACC Review https://doi.org/10.1016/j.jacc.2024.03.416 Lee et al https://heart.bmj.com/content/105/18/1408 III Cannabis and CV Risk Cannabis and MACE in JACC Advances: https://www.jacc.org/doi/10.1016/j.jacadv.2025.101698 Zeraatkar –Grilling the data https://doi.org/10.1016/j.jclinepi.2024.111278 PLOS-1 10.1371/journal.pone.0199705 IV Cardio-oncology Jacc Onc Substdy https://www.jacc.org/doi/10.1016/j.jaccao.2024.11.008 Editorial https://www.jacc.org/doi/10.1016/j.jaccao.2025.01.006 STOP CA JAMA 2023 https://jamanetwork.com/journals/jama/fullarticle/2807988 PREVENT https://evidence.nejm.org/doi/10.1056/EVIDoa2200097 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Estudo publicado no Plos one considera que dançar, seja a que ritmo for, e até sentado e sem música, tem tantos benefícios para saúde como fazer exercício físico.

In this episode we look at pharmacological treatments frequently used for children, particularly neurodivergent children. We discuss the evidence, the pros, the cons, the side effects and the stigma associated with medication for children.References cited:Mechler, K., Banaschewski, T., Hohmann, S., & Häge, A. (2022). Evidence-based pharmacological treatment options for ADHD in children and adolescents. Pharmacology & therapeutics, 230, 107940.Boland, H., DiSalvo, M., Fried, R., Woodworth, K. Y., Wilens, T., Faraone, S. V., & Biederman, J. (2020). A literature review and meta-analysis on the effects of ADHD medications on functional outcomes. Journal of Psychiatric Research, 123, 21-30.https://doi.org/10.1016/j.jpsychires.2020.01.006Garland, E. J., Kutcher, S., Virani, A., & Elbe, D. (2016). Update on the use of SSRIs and SNRIs with children and adolescents in clinical practice. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 25(1), 4.Hetrick, S. E., McKenzie, J. E., & Merry, S. N. (2010). The use of SSRIs in children and adolescents. Current Opinion in Psychiatry, 23(1), 53-57.Catalá-López, F., Hutton, B., Núñez-Beltrán, A., Page, M. J., Ridao, M., Macías Saint-Gerons, D., ... & Moher, D. (2017). The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: a systematic review with network meta-analyses of randomised trials. PloS one, 12(7), e0180355.Dalsgaard, S., Nielsen, H. S., & Simonsen, M. (2014). Consequences of ADHD medication use for children's outcomes. Journal of health economics, 37, 137-151. https://doi.org/10.1016/j.jhealeco.2014.05.005

Wir alle haben Träume, groß und kleine. Aber wie bleiben wir mit ihnen in Kontakt? Wie bereichern sie unser Leben? Wir wir es schaffen können Träumen für die Zukunft Raum in unserem Leben zu geben und dennoch im Hier zu Jetzt zu bleiben, leiten Sinja und Boris in dieser Podcastfolge an.Umfrage: Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier. Hintergründe und Studien:Mehr zum Thema WOOP: hier Carrillo, A., Rubio-Aparicio, M., Molinari, G., Enrique, A., Sanchez-Meca, J., & Banos, R. M. (2019). Effects of the best possible self intervention: A systematic review and meta-analysis. PloS one, 14(9), e0222386. Link zur Studie Heekerens, J. B., & Eid, M. (2021). Inducing positive affect and positive future expectations using the best-possible-self intervention: A systematic review and meta-analysis. The Journal of Positive Psycho Link zur Studie Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Folge ansehen auf YouTube https://youtu.be/1t5LIRGjcBgDanke an die Sponsoren: Ess-Wissen Club für PraktikerDein Schlüssel zu aktuellem Ernährungswissen und Vorlagen für die PraxisBleibst Du gerne auf dem Laufenden, ohne in Studienbergen zu versinken? Der EWiP-Club ist Deine Lösung! Wir filtern, übersetzen und kondensieren die neuesten Ernährungserkenntnisse direkt auf Deinen Schreibtisch - in deutscher Sprache und praxisnah aufbereitet.14 Tage ohne Risiko testen. Rabatt-Code PODCAST10 und du bekommst 10% auf die Jahresmitgliedschaft.https://esswissen-club.com/Heute spreche ich mit Dr. Josephine Worseck, einer absoluten Vorreiterin im Bereich Kälteexposition und der Wim Hof Methode. Josephine ist eine der Schlüsselfiguren, die die Wim Hof Methode in Deutschland bekannt gemacht und maßgeblich geprägt hat. Ihr erstes Eisbad nahm sie an seiner Seite von Wim Hof und seither ist sie begeistert von der Kraft der Kälte. Sie ist die Gründerin der ICE Academy und begleitet nun selbst Menschen in Eis.Josephine, als promovierte Molekularbiologin und bringt einen wissenschaftlich fundierten Blick auf die gesundheitlichen und biologischen Effekte der Kälte mit. Mit ihrer einzigartigen Kombination aus Wissenschaft und Praxis zeigt sie, wie du die transformative Kraft der Kälte sicher und effektiv für dich nutzen kannst.Sie erklärt die physiologischen Effekte der Kälteexposition und die Auswirkungen auf das Immunsystem und die mentale Gesundheit.Wir sprechen überKälte als Heilmittel: Kälteexposition fördert die Ausschüttung von Noradrenalin, das Entzündungen hemmt, die Fettverbrennung ankurbelt und das Immunsystem stärkt – eine einfache, aber effektive Methode für mehr Gesundheit.Mentale Stärke durch Kälte: Eisbaden und kalte Duschen sind kurze, prägnante Stressreize, die dir helfen, Stress zu regulieren und mentale Resilienz sowie Selbstvertrauen zu entwickeln.Die Wim Hof Methode: Diese innovative Technik kombiniert Atmung, Kälte und Mindset, um nicht nur deinen Körper, sondern auch deinen Geist zu stärken – ein ganzheitlicher Ansatz für nachhaltige Gesundheit.Der Schlüssel zur Kälte: Der Erfolg von Kälteanwendungen liegt in der Intention. Ob du dein Immunsystem stärken, Stress abbauen oder mentale Stärke entwickeln möchtest – klare Ziele führen zum besten Ergebnis.Sicher und effektiv starten: Kalte Duschen sind der ideale Einstieg in die Welt der Kälteexposition. Mit einer sanften Herangehensweise und eventuell Begleitung durch Workshops kannst du langfristig von den Vorteilen profitieren.KapitelEinführung in die Episode über Kälteexposition und die Wim Hof Methode.(00:00:00)Hintergrund von Dr. Josephine Worseck (00:03:10)Erste Eisbad-Erfahrung (00:09:09)Die Rolle von Adrenalin (00:12:17)Braunes Fettgewebe und Wärmeproduktion (00:14:27)Stress und Kälteexposition (00:19:09)Regulationsfähigkeit durch Kälte (00:23:52)Kälteexposition hilft, die Fähigkeit zur Selbstregulation unter Stress zurückzugewinnen.Kälteexpositionstechniken (00:24:11)Unterschiedliche Temperaturen und Techniken in der Kälteexposition werden besprochen.Optimale Kältebedingungen (00:26:18)Die ideale Temperatur und Dauer für Kältebäder zur Regeneration werden diskutiert.Immunsystem stärken (00:33:04)Kalte Duschen und Bäder können helfen, das Immunsystem schrittweise zu stärken.Buch über Kälteheilkraft (00:36:02)Einstieg in Kälteexposition (00:37:02)Gesundheitscheck vor Kälteexposition (00:38:17)Atemtechniken vor dem Eisbad (00:40:41)Dauer und Häufigkeit der Kälteexposition (00:44:19)Nach der Kälteexposition (00:45:05)Kälteschock-Proteine (00:45:31)Kursangebote und Workshops (00:50:01)Persönliche Erfahrungen (00:54:00)Alles über Dr. Josephine WorseckJosephine betreute im Jahr 2016 eine Studie über die Wim Hof Methode, wo sie von Wim Hof selbst dazu ermutigt wurde, ihr erstes Eisbad zu nehmen. Die transformative Wirkung der Kälte beeindruckte Josephine so sehr, dass sie 2017 ihre akademische Laufbahn aufgab, um sich voll und ganz der praktischen Anwendung und Lehre der Kälteexposition zu widmen. 2024 gründete sie die ICE Academy, deren Ziel es ist, qualifizierte Instruktoren auszubilden, die fundiertes Wissen, Sicherheit und Achtsamkeit im Umgang mit der Kälte vermitteln. In ihrem Buch "Die Heilkraft der Kälte"(2020) fasst Josephine ihre umfassenden Erfahrungen, wissenschaftlichen Erkenntnisse und persönlichen Einsichten zusammen. Als Autorin, Referentin und Kälteexpertin unterstützt sie Privatpersonen, Organisationen und Unternehmen dabei, die Kraft der Kälte auf sinnvolle Weise zu nutzen. Gemeinsam mit ihrem Partner Douwe van den Berg bildet sie Kältebegeisterte zu ICE Coaches aus, die Kälteexposition sicher, verantwortungsvoll und kompetent weitervermitteln.Eisbade Spickzettel: https://www.josephineworseck.com/mein-blog/sicherheit-beim-eisbadenSocial Media Links, WebsiteWEBSEITE: www.josephineworseck.comFACEBOOK: facebook.com/DrJosephineWorseck/INSTAGRAM: instagram.com/josephineworseck/TWITTER: twitter.com/DrWorseckLINKED INN: /www.linkedin.com/in/drworseck/XING: https://www.xing.com/profile/Josephine_WorseckManagement: josephine@schloesser-consulting.berlinKurse & EventsREISEN: https://www.josephineworseck.com/wim-hof-reisen.htmlWORKSHOPS: https://www.josephineworseck.com/wim-hof-workshops.htmlICE ACADEMY AUSBILDUNG:https://www.josephineworseck.com/ice-ausbildung.htmlBuchempfehlungDie Heilkraft der Kälte von Dr. Josephine WorseckAmazon Link: https://amzn.to/4fChXiGDie Wim-Hof-Methode: Sprenge deine Grenzen und aktiviere dein volles Potenzial. Mit der Kraft der Kälte, bewusster Atmung und mentaler Stärke gesünder, leistungsfähiger und glücklicher werdenAmazon Link: https://amzn.to/3OiTy5SRelevante ArtikelBlades, Robin, et al. "A Randomized Controlled Clinical Trial of a Wim Hof Method Intervention in Women with High Depressive Symptoms." Comprehensive Psychoneuroendocrinology (2024): 100272.https://www.sciencedirect.com/science/article/pii/S2666497624000481Almahayni, Omar, and Lucy Hammond. "Does the Wim Hof Method have a beneficial impact on physiological and psychological outcomes in healthy and non-healthy participants? A systematic review." Plos one 19.3 (2024): e0286933.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286933 Bitte beachte auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf meiner Webseite.

For much of history, the word 'epidemic' applied to infectious diseases. Large numbers of cases of disease caused by organisms such as bacteria and viruses that spread through water, air, or other means, sometimes transmitted from person to person, or back and forth between people and animals. Then came epidemics of chronic diseases such as obesity, diabetes, heart disease - diseases occurring in very large numbers and created not by infectious agents, but by drivers in our day to day lives, such as a bad food environment. A new paper was just published in the PLOS global health literature that I found fascinating. It focuses on another use of the concept of epidemics: market driven epidemics. Let's find out what these are and find out a little bit more about their implications for our health and wellbeing. Our guests today are two of the authors of that paper. Dr. Jonathan Quick is a physician and expert on global health and epidemics. He is an adjunct professor at Duke University's Global Health Institute. Eszter Rimanyi joins us as well. She works on chronic disease and addiction epidemiology at Duke university. Interview Summary Access the PLOS article “Dynamics of combatting market-driven epidemics: Insights from U.S. reduction of cigarette, sugar, and prescription opioid consumption.” So, Jono, let's start with you. Tell us what you mean by market driven epidemics. The pattern is familiar to people. There is a product that that humans like and the business community says we can make a lot of money on this unmet need. And so they do that and they start selling a lot of it. And then people start noticing that this thing that the humans like is killing some of them. And so, the scientists do the public health. And then the business community says these scientists are going to kill the golden goose. They buy up other scientists and try to defend themselves. And then it goes on and on before we really bend the epidemic curves. This pattern of consumer products that have harmful effects, those products are major contributors to the root causes of at least a million deaths a year in the US, and over 20 million deaths worldwide. So, to try to look at this from an epidemic point of view, we first established a case definition. Our definition of market driven epidemic is a significant increase in death, disability and other harmful effects on humans and human health and wellbeing. It's arising from a consumer product whose use has been accelerated by aggressive marketing. Whose harmful effects have been denied or otherwise minimized by producers. And for which effective mitigation is possible but actively opposed by producers. So, we looked at the natural history of this, and we found five phases through which these epidemics pass. There's market development, either inventing a new product, developing a product like prescription opioids, or transforming an existing product like tobacco. Phase two is evidence of harm. First, there's suspicion, astute clinicians, whistleblowers, and then eventually proof of harm. Phase three is corporate resistance. Companies deny harm, seek to discredit accusers, commission counter science, manufacture doubt, mount legal challenges. All the while deaths and social upheaval and economic costs are mounting. And finally, our next phase four is mitigation. We get some regulatory efforts going, and there's a tipping point for the consumption and resulting deaths. And then finally, phase five of this is market adaptation. In a response to decreasing or threatened consumption, companies and consumers typically seek alternatives. Adaptations can be positive or negative. Some are healthier, some are equally or more harmful. Thanks very much for that description. It really helps explain what the concept is all about. You chose three areas of focus. You could have chosen others, but you chose cigarettes, sugar, and prescription opioid use. Why those in particular? We wanted to identify differences in these market driven epidemics in a few product categories. We wanted to look at distinctly different consumer experiences so we could see what worked and what didn't in terms of bending the epidemic curve. We picked nicotine delivery, food, and prescription medicine. And to choose within those categories we established five inclusion criteria. So, number one, the product had to have proven adverse health effects. Number two, there needed to be well documented histories of product development, marketing, mitigation efforts, and so forth. Number three, the product needed to meet the overall case definition. That is, companies knew they were doing harm, continued to do harm, and fought that harm. Number four, there needed to be long term data available for product consumption and associated impact. And number five, most important, we chose products for which mitigation efforts had already resulted in significant sustained reduction in product consumption. Based on these three criteria, cigarettes, sugar, and prescription opioids came out as the ones that we studied. Thanks. I really appreciate that description. And when we get to the punchline in a minute, it's going to be interesting to see whether the behavior of the industry in this natural history that you talked about is similar, given that the substances are so different. We'll get to that in a minute. So Eszter, I'd like to turn to you. What kind of information did you pull together to write this paper? I think I looked at over a thousand different documents. But there were two clear types that I interrogated to pull together all of our background data. The first category was publicly available data, so that could have been a clinical study, epidemiological study, advertisement by the company, CDC or other government reports, mortality data, etc. But then there was also a distinct different type of data that we really looked at and that was really useful for putting together these pictures of the natural history, which was internal documents. In some cases, these could have been leaked by an internal employee, which was the case with the so called 'brown documents' with tobacco. But it also came from sometimes court hearings or as a result of lawsuits that the companies had to release internal data. It was really interesting to compile together the different sides, of the outside look from CDC reports, and then the insider scoop from Purdue Pharma. So, it's a very well rounded, interesting way to find all this data. I admire your effort. It's a big job to do a normal scientific review where you might have 50 papers and you were looking at things that were much harder to obtain and a vast number of things that are really quite different in character. Boy, congratulations for just reading all those things. Tell us what you found. Gosh, so even though there's so many distinct differences between a lot of these epidemics, what we actually found was that there was a lot of narrative similarities. And because of that, we could really create this holistic, but also really well-fitting idea of market driven epidemics. A lot of the corporate strategies were either mirrored, imitated, or in some cases quite literally lifted over because of overlapping ownership between the companies. One of the things that we really wanted to hammer into our article was that producers not only created their product, but they also manufactured doubt. Which means that they created, on purpose, public hesitancy around their product even when they internally knew that it was harmful to health. They wanted the public to be on the fence about what the health impact of their product was. There was a lot of different ways that they achieved that goal. Sometimes it was through showing propaganda films in high schools. Which I still can't believe that happened and then that was legal. But also in different ways, like co-opting science, paying scientists to publish articles in their favor. I know a really famous example of this that has now been public is that two Harvard researchers in cardiovascular disease published saying that sugar was not harmful to health. So, there's a lot of different ways that they achieved it, but the goals overall were very similar by all the companies. You know, you mentioned overlapping ownership. And so, you might have been referring specifically to the ownership of the food companies by the tobacco companies. Correct. Because it happened a while ago, that's not something that was well known. But there's a fascinating history there about how the tobacco industry used its technology to maximize addiction and used that to develop food products and to change the DNA of the food companies in ways that still exist today, even though that ownership ended many years ago. I'm really glad you pointed that out. Yeah, exactly. I think there's this shared idea that there's a turning point for companies. Where they know internally that their product is causing harm. And what really tips them over into becoming market driven epidemics is not actually coming out and saying that there's an issue with their product or not improving it. But you know really digging that information into the dirt and saying no we're going to protect our product and keep giving this out to the public despite the harms. You know, maybe we can come back to this, but the fact that you're finding similarities between these areas suggests that there are contingencies that act on corporate executives that are similar no matter what they're selling. And that's helpful to know because in the future, you can predict what these companies will be doing because there are many more similarities than differences. Jono let me ask you this. You've talked about this appalling period of time between when there are known health consequences of use of some of these things and the time when meaningful action occurs to curb their consumption and to rein in the behavior of the companies. How long is this gap, and what explains it? Kelly, this is one of the most fascinating things about this study. And it really highlights the importance of taking an epidemiologic approach. This is a behavioral epidemic, not a viral one. But it has so many characteristics. One of the key points is that is how important time is. And we see that in any epidemic curve when things start going exponential. If we take cigarettes, okay, the harms of cigarettes had long been suspected. But the first credible scientific publication was by a US physician, Isaac Adler, in a 400-page 1912 book where he first associated cigarettes with cancers. Fast forward over 40 years to British scientists Doll and Hill, and they did the epidemiology which definitively and convincingly links cigarette cancer with smoking deaths. So that gap was incredible and so that's one of the first examples. Once those articles were published, others followed the initial one. It took about a decade until the 1964 Surgeon General's report on smoking and health. And that was quickly followed by a series of federal actions. So, 1964, '63, '64 was the tipping point. Five decades after the initial suspicion. For sugar, the journey from suspicion to compelling evidence was more complex. There was a big debate between researchers, clinicians, scientific journalists, that began in the '50s. A diabetologist from Britain John Yudkin, argued in the 1957 Lancet piece, it's sugar that's equal or larger than fats. An American physiologist, Enzo Keyes, says au contraire. He said it on the cover of Time Magazine. From 1950 to 2000, there was this debate back and forth. Finally, sugar consumption in the US peaked in '99 when a sugar wary group of researchers, journalists, and advocacy groups began becoming really vocal. And that was the tipping point. The actual compelling science, it came a few years after the preponderance of folks engaged said, no, it's sugar. You got to do something. And finally, with prescription opioids: 1997, rural doctors Art Van Zee and another fellow, alerted Purdue Pharma, the producer of OxyContin, about rising overdoses. A year later, there was a publication that said the sustained release version of OxyContin, which was a hydrocodone that was sustained release, that they first tried it with morphine, and they had evidence from there that the sustained release drugs were a problem. And again, it was over a decade later that mounting prescription opioid deaths in the US convinced CDC to declare an epidemic of [00:14:00] opioid prescribing. This gap, if you look at it, to summarize, for cigarettes, the journey from credible suspicion of harm to consumption tipping point, five decades. Sugar, four decades. Prescription opioids, fourteen years. But the key thing is that the power of collective action, because today, only one in eight Americans smoke, and it was nearly 50 percent at the peak. The US consumption of sugar, which increased by 30 pounds between the year 1950 and the year 2000, when all this debate was going on. We picked up an extra 30 pounds of sugar consumption per person per year, but within two decades, that was cut back. We gave back 15 pounds of that. And now prescription opioids have gone back to a medically defendable level, having risen to 8 to 10 times that in the peak of the prescription opioid epidemic. Hearing you talk about that, it's nice that there's sometimes light at the end of the tunnel. But boy, it's a long tunnel. And that you can count the, the number of deaths during that tunnel period of time in the millions. It's just unspeakable how much damage, preventable damage gets caused. Now, and I'd like to, when I come back to wind up this podcast, I'd like to ask each of you, what do you think might be done to help narrow that or shrink that time gap and to prevent these long delays and to help address these corporate determinants of health. But before I get there, Eszter, you know, I'd like to follow up on the conversation we had earlier. You know where it's clear that sugar and tobacco and opioids are all quite different substances, but the companies, the natural history of these things looks quite similar. And you mentioned in particular the industry attempt to plant doubt. To create doubt in the minds of people about the stories they were hearing of the dangers of these things, whether they were true or not. And were there other things that the industry was doing during that time that you noticed might have similarities across these areas? Oh my gosh, so many. I have to go through all the examples in my head and make sure that I have a very crisp message out of all of them One of the ones that is interestingly being employed today in a very different epidemic with firearms and guns, is this idea of whose choice is the consumer product in its use. And today there's a lot of ideas that were initially created by tobacco, and then used by food, that are currently being used by gun lobbyists talking about individual freedoms. So with some of the previous market driven epidemics, like tobacco and prescription opioids, it's a way easier argument to make that the individual at some level does not choose to use the product. Maybe in the beginning, the first couple uses were their individual choice, but then there's on purpose, a really strong withdrawal response in the body and socially. The individual kind of had to continue using the product. But some of those ideas are being used today with firearms. The idea that somebody has the liberty to use this product or to purchase this product, which undoubtedly causes harm. You know, it's probably not really good for public health if this argument exists. And, in the cases with firearms, which I think is a little bit ironic and sad, a lot of the people that buy guns for their own self-defense actually experience those guns turned around and used on them, usually by the perpetrators of aggression. These ideas of individual freedoms usually backfire to the people that are consuming the products. It's interesting to me that a lot of these ideas were initially created for very different products, but are being used in the current day. So interesting to hear you say that because here we have yet another area where there are similarities with the firearms. And the companion argument to that idea that it's your personal liberty to use these things is the argument that there's overreach by government, big brother, things like that. When government wants to, you know. Yeah. It's so interesting. So one point on that. The market economy was never meant to be a free for all. Because the reality is that the market economy has brought billions of people out of poverty and saved more lives than most health interventions. But the problem is, as I said, it wasn't meant to be a free for all. And it depends on having good consumer information and when companies are distorting it, they're basically taking away the informed choice, which is critical. The other part of it is, when they are purposely engineering their products for maximal addictiveness, which is done with clicks and social media, and was done purposefully with the nicotine content in cigarettes, then you don't have a real informed choice. The freedom of choice. You've had your brain pleasure center hijacked by, by purposely addictive products. Right, and you didn't mention food, but there's another example of substances that are created to hijack the reward pathway in the brain. Absolutely. I'd like to ask each of you, what in the heck can we do about this? I mean, you've pointed out a massive problem. Where the number of lives that are sacrificed because of corporate behavior, just enormous numbers. What can we do about it? Jono, I will start with you. And, you know, you've written this very highly regarded book called The End of Epidemics. And you've talked about things like bending epidemic curves and accelerating shifts. But tell us more. What do you think can be done in the case of these market driven epidemics like we're talking about? Well, I think it's important to realize that both kinds of epidemics, viral and behavioral, are communicable. Both involve a lot of rumor, blame, uncertainty. And as we've talked about both cause deaths in the thousands or millions. And we haven't talked so much about the significant social disruption, and the cost. Trillions of dollars in economic losses and additional health burdens. So let me focus on four kinds of key actors because when it comes down to it, it's groups that that really start acting against these things. The first is the research community and its funders. You won't be surprised given the time it takes to get the evidence because what's clear is without clear evidence of product associated harm, we're not going to move the political agendas. We're not going to get public support for epidemic curves. So, we have really good researchers working in these areas. They need to guard against groupthink. That's what happened with our salt sugar 50 years of chaos discussion. And conflict of interest because companies do try to undermine the database. The second is the funders of research, foundations and all, and national health services need to have an early warning system and an annual research roadmap in this area. I think Eszter will probably talk about the importance of public health leaders, because she's looked a lot at that. Another community though is the different civil society groups that are active. Because there's Mothers Against Drunk Driving, there's the Sandy Hook group on gun shooting, and there are a variety of interest groups. But what we realize is that there are lots of different strategies for how you move decision makers and all. So, more information sharing from those groups, civil society groups and all across. And finally, companies. It's actually in their interest to be more forthcoming earlier on. With tobacco, with prescription opioids, and now with baby powder, with talc, what we're seeing is companies at risk of bankruptcy paying billions of dollars. And if their CEOs aren't looking at that, then their board needs to be. Can I ask you a quick question about that? When the chickens come home to roost, and those bad things befall a company, you know, really seriously damaging lawsuits, or the possibility that perhaps sometime the executives will go to jail for corporate malfeasance. You know, the behavior that caused all the millions of deaths occurred 15 CEOs before them. So, if you're a CEO and you know you have a certain shelf life as CEO, you want to maximize profit during that time. And by the time anything happens negatively to the company, you're on vacation, you're retired, or you're gone. So how do you deal with that? Here's the thing, it's having criminal and civil liability that can go back to the individuals involved. From a different sector, an example. The German executive who was head of Volkswagen over a decade ago when they cheated on their environmental issues. He's been criminally charged today, a decade later. And I think that sort of personal accountability, it'll be hard to get, but that's the kind of thing that will make CEOs and their boards, if their boards also become responsible for hiding information in a way that it resulted in deaths. I think that, unfortunately, that kind of hammer, although it's going to be hard to get, that's probably what's needed. Okay, that makes good sense to me, and I'm glad I asked you that question. And I appreciate the answer. Eszter, anything you'd like to add to what Jono said about what could be done. Yes. One of the amazing things about market driven epidemics was when we were creating the paper, we created a table of all the different types of actors that could have very successful mitigation. And that table actually ended up being cut from the paper because it was so long that the editor said that it might distract from the rest of the paper. But that's actually a very positive message because there are so many actors that can have positive change, I'm going to highlight a couple of them because I think there's a few things here that are fairly good core messages that we can take away. One of the ones is the need for a trusted public health authoritative voice. I think nowadays there's a lot of commotion over how much we trust the government. And how much we trust, for example, the head of the CDC and the types of data they're talking about in terms of public health. But in the past, when we had a very trusted public health voice, that was really crucial in getting consumers to change their behavior. For example, in the 1964 Surgeon General's report, seemingly overnight changed people's behavior. Before then, smoking was a common, everyday social event. And after that, people started viewing it as a deadly, bad habit that some people had. And that type of change was really hard to get in the modern day. When we were talking about public health crises that were viral. So, I think one of the things that we really need to get again in the modern day is this trust between the people and public health voices so that when we have such good forthcoming information those statements actually mean something. So much so that the consumers change their behavior. Another thing is with us individuals who maybe aren't part of public health, we actually play a pretty big role in how much other people consume these different products. I remember when I was researching cigarettes in particular and the intersection with social media. I think if somebody under 18 saw a peer smoking and posted that to Instagram, that doubled their likelihood of trying out smoking for the first time. You have to be really careful with how you show yourself in the presence of others, and online too with a new digital age. Because you might tip the scale in somebody trying out a product for the first time. Which then if it has a very strong withdrawal effect, you know that person might have to might feel that they have to continue using that product to avoid withdrawal. I think as an individual, you can be more mindful about if you have a certain product use that you don't want others to also pick up, to maybe not do it or not show it as much so that other people aren't interested in doing that. Okay, the last really positive message I have is that I think as my generation gets into higher positions of power, even within corporations, I think Gen Z and Gen Alpha and other young people have the sense of responsibility for others and for the planet. And I think if there was a young person in power in a corporation and saw that oh no this product that we've had is now there's evidence that's harmful. I think there would be more accountability and more of a want to do something that's good for the planet and for people. I'm hopeful that, maybe 50, 60 years ago, if people were more in favor of kind of brushing things under the rug, then maybe the young generation won't be as into those ideas. And we'll actually want to be accountable and do what's right. BIOS Jonathan D. Quick, MD, MPH (“Jono”) is adjunct Professor of Global Health at the Duke Global Health Institute, where he teaches global health policy, serves on foundation grant advisory boards, and mentors students. Dr. Quick's current research and writing focuses on market-driven epidemics, from tobacco to opioids to social media.  He is also Affiliated Faculty in Global Health Equity, Brigham and Women's Hospital/Global Health & Social Medicine, Harvard Medical School. Dr. Quick is the author of The End of Epidemics: The Looming Threat to Humanity and How to Stop It  (Australian, Italian, Korean, South Asia, U.K. and U.S. 2018/2020/2021 editions), creator of MDS-3: Managing Access to Medicines and Health Technologies and an author of  The Financial Times Guide to Executive Health, Preventive Stress Management in Organizations, as well as more than 100 other books, chapters, and articles in leading medical journals.  Eszter Rimanyi is a chronic disease epidemiologist working with Dr. Jonathan D. Quick at the Duke Global Health Institute. Her research interest centers around Market-Driven Epidemics, including tobacco, sugar, opioids, and breastmilk substitute/infant formula. She is currently working on applying the market-driven epidemics approach to new epidemics, such as social media and firearms. Rimanyi has authored scientific papers in journals such as PloS Global Public Health and MDPI.

TakeawaysCarnivore Ernährung wird als therapeutisches Werkzeug betrachtet.Fleisch hat eine zentrale Rolle in der menschlichen Evolution gespielt.Morphologische Anpassungen des Menschen unterstützen eine fleischbasierte Ernährung.Die Nährstoffdichte in tierischen Lebensmitteln ist höher als in pflanzlichen.Es gibt keine dokumentierten veganen Jägersammlergesellschaften.Gesättigte Fette sind in ihrer natürlichen Matrix unbedenklich.Die Inuit und andere Jägersammlergesellschaften zeigen, dass eine fleischlastige Ernährung gesund sein kann.Evidenzbasierte Ansätze sind entscheidend für die Ernährung.Kapitel00:00 - Einleitung: Ist carnivore Ernährung wirklich Unsinn? 01:00 - Fleisch und Evolution: Die Rolle der Steinwerkzeuge 02:50 - Australopithecus: Erste Hinweise auf Fleischkonsum 04:20 - Eiszeit und große Jäger: Homo erectus und die Megafauna 06:30 - Übergang zur Sesshaftigkeit: Ein langsamer Prozess 09:00 - Unsere Anatomie: Zähne, Magen und Verdauungstrakt 11:30 - Nährstoffe aus tierischer Nahrung: Hohe Dichte und Bioverfügbarkeit 13:50 - Antioxidantien, Ketose und entzündungsarme Ernährung 16:10 - Fehlende große Studien? Evidenz aus Fallstudien und Evolution 18:30 - Fazit: Fleisch als zentrales Nahrungsmittel der Menschheit Original Artikel: Iss Dich Gesund / 01-2025/ Seite 79 "Riedls Aufreger"Literaturquellen:Heinzelin, Jean de, et al. "Environment and behavior of 2.5-million-year-old Bouri hominids." Science 284.5414 (1999): 625-629.Richards, Michael P., and Erik Trinkaus. "Isotopic evidence for the diets of European Neanderthals and early modern humans." Proceedings of the National Academy of Sciences 106.38 (2009): 16034-16039.Mann, Neil. "Meat in the human diet: An anthropological perspective." Nutrition & Dietetics 64 (2007): S102-S107.Fujimori, Shunji. "Gastric acid level of humans must decrease in the future."World Journal of Gastroenterology 26.43 (2020): 6706Blumenschine, Robert J., et al. "Characteristics of an early hominid scavenging niche [and comments and reply]." Current anthropology 28.4 (1987): 383-407.Aiello, Leslie C., and Peter Wheeler. "The expensive-tissue hypothesis: the brain and the digestive system in human and primate evolution." Current anthropology (1995): 199-221.Gurven, Michael, and Hillard Kaplan. "Longevity among hunter‐gatherers: a cross‐cultural examination." Population and Development review 33.2 (2007): 321-365.Cordain, Loren, et al. "Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets." The American journal of clinical nutrition 71.3 (2000): 682-692.Lescinsky, Haley, et al. "Health effects associated with consumption of unprocessed red meat: a Burden of Proof study." Nature Medicine 28.10 (2022): 2075-2082.Astrup, Arne, et al. "Saturated fats and health: a reassessment and proposal for food-based recommendations: JACC state-of-the-art review." Journal of the American College of Cardiology 76.7 (2020): 844-857.Yamada, Satoru, et al. "Saturated Fat Restriction for Cardiovascular Disease Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Trials." (2024).Beasley, DeAnna E., et al. "The evolution of stomach acidity and its relevance to the human microbiome." PloS one 10.7 (2015): e0134116.Norwitz, Nicholas G., and Adrian Soto-Mota. "Case report: Carnivore–ketogenic diet for the treatment of inflammatory bowel disease: a case series of 10 patients." Frontiers in Nutrition 11 (2024): 1467475.Calabrese, Lori, Rachel Frase, and Mariam Ghaloo. "Complete remission of depression and anxiety using a ketogenic diet: case series." Frontiers in Nutrition 11 (2024): 1396685.Cordain, Loren, et al. "The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic." European journal of clinical nutrition 56.1 (2002): S42-S52.Beal, Ty, and Flaminia Ortenzi. "Priority micronutrient density in foods." Frontiers in nutrition 9 (2022): 806566.Ben‐Dor, Miki, Raphael Sirtoli, and Ran Barkai. "The evolution of the human trophic level during the Pleistocene." American journal of physical anthropology 175 (2021): 27-56. Bitte beachte auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf meiner Webseite.

This episode of Walk, Don't Run to the Doctor emphasizes the importance of building and maintaining a healthy microbiome for better health outcomes, disease prevention, and overall well-being. The microbiome, a complex population of microorganisms living in the gut, plays a significant role in protecting against cancer, regulating digestion, and supporting various metabolic and immune functions. A home-cooked diet, particularly a whole food omnivorous diet rich in fiber and fermented foods, helps to cultivate a resilient microbiome. Exercise, scant to moderate alcohol consumption (especially wine), and avoiding sugar, refined flours, and artificial sweeteners further enhance gut health. This episode also warns against overuse of antibiotics and reliance on probiotic supplements, advocating instead for a food-based approach through diet and lifestyle changes. Key Takeaways: Microbiome's Role in Health: The microbiome impacts everything from cancer prevention to appetite regulation, insulin sensitivity, immune function, and even brain health. Diet and Gut Health: A Mediterranean-style, omnivorous whole food, diet improves microbiome diversity and overall health, reducing risks for conditions like obesity, diabetes, and cancer. Fermented Foods: Incorporating fermented foods like yogurt, kefir, and kombucha supports a healthy microbiome and reduces cancer risk. Exercise and Lifestyle: Regular exercise promotes gut health and boosts immunity, while avoiding sugar, artificial sweeteners, and unnecessary antibiotics helps maintain microbiome balance. Natural Approach: The podcast recommends focusing on diet and lifestyle over probiotic or prebiotic supplements to build a resilient microbiome. For more insights and advice on reducing dependence on medications through lifestyle changes, make sure to subscribe to Walk, Don't Run to the Doctor. More references can be found at www.GreatMed.org Would you like Dr. Hassell to answer your question on the air?  Contact us! Phone/text: 503-773-0770 e-mail: info@GreatMed.org Write us a letter.  We love to hear from you.  This podcast is sponsored by our generous listeners.  Send questions, comments, and support to: 4804 NW Bethany Blvd., Suite I-2, #273 Portland OR 97229 References:           Zhang, X., et al. (2023). Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights form the BE GONE trial. The Lancet, 98:104873. https://doi.org/10.1016/j.ebiom.2023.104873            Diez-Ozaeta, I. & Astiazaran, O. (2021). Fermented foods: An update on evidence-based health benefits and future perspectives. Food Research International, 156. https://doi.org/10.1016/j.foodres.2022.111133            Perler, B., et al. (2023). The role of the gut microbiota in the relationship between diet and human health. Annual Reviews in Physiology, 85:449-68. https://doi.org/10.1146/annurev-physiol-031522-092054            DeVos, W., et al. (2022). Gut microbiome and health: mechanistic insights. Gut-BMJ, 71:1020-1032. doi: 10.1136/gutjnl-2021-326789            Kim, J., and Le, H. (2022). Potential role of the gut microbiome in colorectal cancer progression.  Frontiers in Immunology, 12: 807648. doi: 10.3389/immu.2021.807648            Pyo, Y., et al. (2024). Probiotic functions in fermented foods: Anti-viral, Immunomodulatory, and anti-cancer benefits. Foods, 13:2386. https://doi.org/10.3390/foods13152386            Zhang, K., et al. (2019) Fermented dairy foods intake and risk of  cancer. International Journal of Cancer, 144: 2099-2108.            Michels, K. B., et al. (2020). Yogurt consumption and colorectal cancer incidence and mortality in the Nurses' Health Study and the Health Professionals Follow-Up Study. The American journal of clinical nutrition, 112(6), 1566–1575. https://doi.org/10.1093/ajcn/nqaa244            Shams-White, M., et al. (2022). The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk: A Longitudinal Analysis in the NIH-AARP Diet and Health Study, Current Developments in Nutrition, Volume 6, Issue 6, nzac096,ISSN 2475-2991,https://doi.org/10.1093/cdn/nzac096.            Rad, A., et al. (2021). Postbiotics as promising tools for cancer adjuvant therapy. Advanced Pharmaceutical Bulletin, 11(1), 1-5. https://apb.tbzmed.ac.ir            Sharma, A., et al. Final results of a phase I/II study to investigate efficacy of a high potency multistrain probiotic on chemo induced diarrhea. ESMO, 29(8). Doi:10.1093/annonc/mdy424            Luceron-lucas-Torres, M., et al. Association between wine consumption and cancer: a systematic review and meta-analysis. Frontiers in Nutriition, 10:1197745. doi: 10.3389/fnut.2023.1197745            LeRoy, C., et al. (2020). Red  Wine Consumption  Associated with increased gut microbiota a-diversity in 3 independent cohorts. Gastroenterology, 158:270-272. https://doi.org/10.1053/j.gastro.2019.024            Duan, J., et al. (2021). The mechanisms of wine phenolic compounds for preclinical anticancer therapies. Food and Nutrition Research, 65:6507. http://dx.doi.org/10.29219/fnr:v65.6507            Zhao, L., et al. (2023). Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Liver Cancer and Chronic Liver Disease Mortality. JAMA, 330(6), 537–546. https://doi.org/10.1001/jama.2023.12618            Debras, C., et al. (2022). Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLoS medicine, 19(3), e1003950. https://doi.org/10.1371/journal.pmed.1003950            Zhang, J., et al. (2019). Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study. Gut.BMJ; 68:1971-1978. doi: 10.1136/gutnl-2019-318593

Dr. Michele Gelfand is a cultural psychologist and author of Rule Makers, Rule Breakers. She joins us to discusses how “tight” and “loose” cultures shape societies. Tight cultures, like Japan's, respond to threats with strict rules and order, while looser ones, like the U.S., allow greater flexibility. Gelfand suggests a balanced “Goldilocks” approach, adjusting strictness and flexibility to suit each environment's needs, from families to organizations. She also explores online accountability, recommending "nudges" to promote civility, and sees AI as a potential tool for managing biases and promoting understanding.     Guest Bio Michele Gelfand is a Professor of Organizational Behavior at the Stanford Graduate School of Business and Professor of Psychology by Courtesy at Stanford University. Gelfand uses field, experimental, computational, and neuroscience methods to understand the evolution of culture--as well as its multilevel consequences for human groups. Her work has been cited over 20,000 times and has been featured in the Washington Post, the New York Times, the Boston Globe, National Public Radio, Voice of America, Fox News, NBC News, ABC News, The Economist, De Standard, among other outlets.   Gelfand has published her work in many scientific outlets such as Science, the Proceedings of the National Academy of Sciences, Proceedings of the Royal Society B, Psychological Science, Nature Scientific Reports, PLOS 1, the Journal of Personality and Social Psychology, Organizational Behavior and Human Decision Processes, Academy of Management Review, Academy of Management Journal, Research in Organizational Behavior, Journal of Applied Psychology, Annual Review of Psychology, American Psychologist, Journal of Cross-Cultural Psychology, Current Opinion in Psychology, among others. She has received over 13 million dollars in research funding from the National Science Foundation, Department of Defense, and the FBI.   As a native New Yorker, Michele is now a California transplant. She is married to Todd Betke and has two daughters, Jeanette and Hannah, two birds (Bonnie and Theo) and a Portuguese water dog, Pepper.     Show Notes (1:47) What is culture? (4:08) The age that we start learning norms (10:01) What makes a person or nation a tight versus a loose culture (15:12) How the movement of people affect looseness and tightness dynamics (17:57) How changes in attitudes occur (20:59) Tightness doesn't mean a lack of creativity (24:26) The Goldilocks Approach (30:49) Avoiding becoming too tight or too loose (32:55) Applying the Goldilocks Approach on social media (35:56) The disrupting force technology can have on loose and tight cultures (38:19) AI's ability to understand culture (41:11) What's next for Dr. Michele Gelfand (45:00) How to follow Michele's work     Links Referenced Values, Political Action, and Change in the Middle East and the Arab Spring: https://www.amazon.com/Values-Political-Action-Change-Middle/dp/019026909X Rule Makers, Rule Breakers: How Tight and Loose Cultures Wire Our World: https://www.amazon.com/Rule-Makers-Breakers-Tight-Cultures/dp/1501152939 Personal website: michelegelfand.com  

Wenn etwas Schlimmes passiert, dann haben wir Menschen verschiedene Strategien, wie wir damit umgehen. Das nennt man Coping. In dieser Folge geht es darum, wie wir belastende Dinge mithilfe dieser Methode besser verarbeiten können. **********An dieser Stelle findet ihr die Übung:00:31:33 - Übung zu Bewältigungsstrategien**********Dianes und Main Huongs Empfehlungen:Folkman, S., & Moskowitz, J. T. (2004). Coping: Pitfalls and promise. Annu. Rev. Psychol., 55(1), 745-774.effer, T., & Willoughby, T. (2017). A count of coping strategies: A longitudinal study investigating an alternative method to understanding coping and adjustment. PloS one, 12(10), e0186057.**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok auf&ab , TikTok wie_geht und Instagram .**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de

In this episode, we dive deep into the literature on coyotes and explore the impacts of their interactions with turkeys. Join as we delve into the science of coyote predator-prey dynamics, the expansion of coyote populations across North America, their diets and impacts on turkey populations, research conducted on the efficacy of trapping, and more.    Resources: Cherry, M. J., et al. (2016). Coyote diets in a longleaf pine ecosystem. Wildlife Biology, 22(2), 64-70. Conner, L. M., et al. (2016). Predator exclusion as a management option for increasing white‐tailed deer recruitment. The Journal of Wildlife Management, 80(1), 162-170. Gulsby, W. D., et al. (2015). White‐tailed deer fawn recruitment before and after experimental coyote removals in central Georgia. Wildlife Society Bulletin, 39(2), 248-255. Hickman, J. E., et al. (2016). Home range, habitat use, and movement patterns of female coyotes in Georgia: implications for fawn predation. Journal of the Southeastern Association of Fish and Wildlife Agencies, 2, 144-150. Hody, J. W., & Kays, R. (2018). Mapping the expansion of coyotes (Canis latrans) across North and Central America. ZooKeys, (759), 81. Houchin, R. L. (2005). Coyote predation on the Rio Grande wild turkey in the Texas Panhandle and southwestern Kansas (Doctoral dissertation). Kelly, J. D., et al. (2015). Seasonal and spatial variation in diets of coyotes in central Georgia. Journal of the Southeastern Association of Fish and Wildlife Agencies, 2, 296-302. Kilgo, J. C., et al. (2014). Coyote removal, understory cover, and survival of white‐tailed deer neonates. The Journal of Wildlife Management, 78(7), 1261-1271. MacCracken, J. G., & Uresh, D. W. (1984). Coyote foods in the Black hills, South Dakota. The Journal of wildlife management, 48(4), 1420-1423. Mastro, L. L., et al. (2019). Home range and habitat use of West Virginia Canis latrans (Coyote). Northeastern Naturalist, 26(3), 616-628. Melville, H. I. (2012). The impacts of three common mesopredators on the reintroduced population of Eastern Wild Turkeys in Texas. Texas A&M University. Miller, D. A., et al. (1998). Survival and cause-specific mortality of wild turkey hens in central Mississippi. The Journal of wildlife management, 306-313. Niedzielski, B., & Bowman, J. (2015). Survival and cause-specific mortality of the female eastern wild turkey at its northern range edge. Wildlife Research, 41(7), 545-551. Sasmal, I., et al. (2019). Seasonal space use of transient and resident coyotes (Canis latrans) in North Carolina, USA. Canadian Journal of Zoology, 97(4), 326-331. Schrecengost, J. D., et al. (2008). Seasonal food habits of the coyote in the South Carolina coastal plain. Southeastern Naturalist, 7(1), 135-144.  UF DEER Lab Coyote FB Post Wang, G., Butler, A. B., & Shan, X. (2023). Inverse relationships between coyote and wild turkey population time series: Implications for future studies of predator–prey interactions. Wildlife Letters, 1(4), 171-177. Youngmann, J. L., et al. (2023). Assessing springtime vertebrate prey of sympatric mesopredators in the southeastern United States using metabarcoding analysis. Plos one, 18(10), e0293270.   Donate to wild turkey research: UF Turkey Donation Fund , Auburn Turkey Donation Fund  Do you have a topic you'd like us to cover? Leave us a review or send us an email at wildturkeyscience@gmail.com!   Dr. Marcus Lashley @DrDisturbance, Publications Dr. Will Gulsby @dr_will_gulsby, Publications Turkeys for Tomorrow @turkeysfortomorrow  UF DEER Lab @ufdeerlab, YouTube   Please help us by taking our (QUICK) listener survey - Thank you!  Check out the NEW DrDisturbance YouTube channel! DrDisturbance YouTube Watch these podcasts on YouTube Leave a podcast rating for a chance to win free gear! This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.    Music by Artlist.io Produced & edited by Charlotte Nowak  

In this episode, we dive deep into the literature on coyotes and explore the impacts of their interactions with turkeys. Join as we delve into the science of coyote predator-prey dynamics, the expansion of coyote populations across North America, their diets and impacts on turkey populations, research conducted on the efficacy of trapping, and more.    Resources: Cherry, M. J., et al. (2016). Coyote diets in a longleaf pine ecosystem. Wildlife Biology, 22(2), 64-70. Conner, L. M., et al. (2016). Predator exclusion as a management option for increasing white‐tailed deer recruitment. The Journal of Wildlife Management, 80(1), 162-170. Gulsby, W. D., et al. (2015). White‐tailed deer fawn recruitment before and after experimental coyote removals in central Georgia. Wildlife Society Bulletin, 39(2), 248-255. Hickman, J. E., et al. (2016). Home range, habitat use, and movement patterns of female coyotes in Georgia: implications for fawn predation. Journal of the Southeastern Association of Fish and Wildlife Agencies, 2, 144-150. Hody, J. W., & Kays, R. (2018). Mapping the expansion of coyotes (Canis latrans) across North and Central America. ZooKeys, (759), 81. Houchin, R. L. (2005). Coyote predation on the Rio Grande wild turkey in the Texas Panhandle and southwestern Kansas (Doctoral dissertation). Kelly, J. D., et al. (2015). Seasonal and spatial variation in diets of coyotes in central Georgia. Journal of the Southeastern Association of Fish and Wildlife Agencies, 2, 296-302. Kilgo, J. C., et al. (2014). Coyote removal, understory cover, and survival of white‐tailed deer neonates. The Journal of Wildlife Management, 78(7), 1261-1271. MacCracken, J. G., & Uresh, D. W. (1984). Coyote foods in the Black hills, South Dakota. The Journal of wildlife management, 48(4), 1420-1423. Mastro, L. L., et al. (2019). Home range and habitat use of West Virginia Canis latrans (Coyote). Northeastern Naturalist, 26(3), 616-628. Melville, H. I. (2012). The impacts of three common mesopredators on the reintroduced population of Eastern Wild Turkeys in Texas. Texas A&M University. Miller, D. A., et al. (1998). Survival and cause-specific mortality of wild turkey hens in central Mississippi. The Journal of wildlife management, 306-313. Niedzielski, B., & Bowman, J. (2015). Survival and cause-specific mortality of the female eastern wild turkey at its northern range edge. Wildlife Research, 41(7), 545-551. Sasmal, I., et al. (2019). Seasonal space use of transient and resident coyotes (Canis latrans) in North Carolina, USA. Canadian Journal of Zoology, 97(4), 326-331. Schrecengost, J. D., et al. (2008). Seasonal food habits of the coyote in the South Carolina coastal plain. Southeastern Naturalist, 7(1), 135-144.  UF DEER Lab Coyote FB Post Wang, G., Butler, A. B., & Shan, X. (2023). Inverse relationships between coyote and wild turkey population time series: Implications for future studies of predator–prey interactions. Wildlife Letters, 1(4), 171-177. Youngmann, J. L., et al. (2023). Assessing springtime vertebrate prey of sympatric mesopredators in the southeastern United States using metabarcoding analysis. Plos one, 18(10), e0293270.   Donate to wild turkey research: UF Turkey Donation Fund , Auburn Turkey Donation Fund  Do you have a topic you'd like us to cover? Leave us a review or send us an email at wildturkeyscience@gmail.com!   Dr. Marcus Lashley @DrDisturbance, Publications Dr. Will Gulsby @dr_will_gulsby, Publications Turkeys for Tomorrow @turkeysfortomorrow  UF DEER Lab @ufdeerlab, YouTube   Please help us by taking our (QUICK) listener survey - Thank you!  Check out the NEW DrDisturbance YouTube channel! DrDisturbance YouTube Watch these podcasts on YouTube Leave a podcast rating for a chance to win free gear! This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.    Music by Artlist.io Produced & edited by Charlotte Nowak  

This week you get just me (Jessica Perry Hekman) talking at you! I'm talking about the coefficient of inbreeding (COI), a measurement of genetic diversity that's commonly mentioned in discussions of individual and breed health. I talk about what it is, how to interpret it, how to get the measurement done for your own dog(s), why we care about it, and give the take-home messages from some papers with evidence for its importance in dog specifically. COI is not the only thing you should be breeding for, and it's rarely even the most important thing - but it's something we should keep in mind when we are working in closed gene pools. I mention some previous podcast episodes with related material - you can find them here: Alison Skipper, PhD on the history of breed registries: https://functionalbreeding.podbean.com/e/alison-skipper-phd-the-history-of-breed-registries/ Mary Peaslee, MD, MPH, on breeding for population health: https://functionalbreeding.org/breeding-for-population-health/ The papers: https://functionalbreeding.org/the-impact-of-inbreeding-on-litter-size/ - Chu ET, Simpson MJ, Diehl K, Page RL, Sams AJ, Boyko AR. Inbreeding depression causes reduced fecundity in Golden Retrievers. Mammalian Genome. 2019 Jun 1;30(5):166-72. - "The least inbred dogs had an average litter size of 8 puppies, while the most inbred dogs had an average litter size of 6-7 puppies. On average, with each 10% increase in inbreeding, the litter size decreased by one puppy." https://functionalbreeding.org/inbreeding-depression-and-lifespan/ - Yordy J, Kraus C, Hayward JJ, White ME, Shannon LM, Creevy KE, Promislow DEL, Boyko AR. Body size, inbreeding, and lifespan in domestic dogs. Conserv Genet. 2020 Feb;21(1):137-148. - mixed breed live on average 1.2 years longer than size matched purebreds https://www.sciencedirect.com/science/article/abs/pii/S1090023313004486 - O'Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Longevity and mortality of owned dogs in England. Vet J. 2013 Dec;198(3):638-43. doi: 10.1016/j.tvjl.2013.09.020 - again, mixed breed live on average 1.2 years longer than size matched purebreds https://link.springer.com/article/10.1186/s40575-020-00086-8 - Urfer SR, Kaeberlein M, Promislow DEL, Creevy KE. Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States. Canine Med Genet. 2020 Jun 16;7:7. -   breeds with lower COI have 3-6 month longer expected lifespans https://functionalbreeding.org/size-genetic-diversity-lifespan/ - Kraus C, Snyder-Mackler N, Promislow DEL. How size and genetic diversity shape lifespan across breeds of purebred dogs. Geroscience. 2023 Apr;45(2):627-643. - + 1% heterozygosity -> + 31 days of life https://functionalbreeding.org/the-effect-of-inbreeding-body-size-and-morphology-on-health-in-dog-breeds/ - Bannasch, D., Famula, T., Donner, J. et al. The effect of inbreeding, body size and morphology on health in dog breeds. Canine Genet Epidemiol 8, 12 (2021). - 30kg dog: 0->40% COI -> 10% increase in veterinary care visits; 5kg or 60kg: 37% increase https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 - Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. - purebred more likely to be affected, mutts to be just carriers

João Mendes. Joanne Alves e Ênio Simas conversam sobre 7 armadilhas na dor lombar. Vote no TdC no Prêmio Melhores Podcasts do Brasil. Estamos na categoria Ciência https://www.premiompb.com.br/ Referências: https://amdg.wa.gov/Files/AssessmentTools/5-Keele_STarT_Back9_item-7.pdf  Chou, Roger, and Paul Shekelle. “Will this patient develop persistent disabling low back pain?.” JAMA vol. 303,13 (2010): 1295-302. doi:10.1001/jama.2010.344 Stevans, Joel M et al. “Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care.” JAMA network open vol. 4,2 e2037371. 1 Feb. 2021, doi:10.1001/jamanetworkopen.2020.37371 Suri, Pradeep et al. “Predictive Validity of the STarT Back Tool for Risk of Persistent Disabling Back Pain in a U.S. Primary Care Setting.” Archives of physical medicine and rehabilitation vol. 99,8 (2018): 1533-1539.e2. doi:10.1016/j.apmr.2018.02.016 Samanta, Jo et al. “10-minute consultation: chronic low back pain.” BMJ (Clinical research ed.) vol. 326,7388 (2003): 535. doi:10.1136/bmj.326.7388.535 Gomes, Luís Antunes et al. “A Stratified Approach for Managing Patients With Low Back Pain in Primary Care (SPLIT Program): A Before-and-After Study.” Annals of family medicine vol. 22,3 (2024): 195-202. doi:10.1370/afm.3104 Richmond, Helen et al. “The Effectiveness of Cognitive Behavioural Treatment for Non-Specific Low Back Pain: A Systematic Review and Meta-Analysis.” PloS one vol. 10,8 e0134192. 5 Aug. 2015, doi:10.1371/journal.pone.0134192 Chou, Roger et al. “Nonpharmacologic therapies for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.” Annals of internal medicine vol. 147,7 (2007): 492-504. doi:10.7326/0003-4819-147-7-200710020-00007 Qaseem, Amir et al. “Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians.” Annals of internal medicine vol. 166,7 (2017): 514-530. doi:10.7326/M16-2367 Flynn, Diane M. “Chronic Musculoskeletal Pain: Nonpharmacologic, Noninvasive Treatments.” American family physician vol. 102,8 (2020): 465-477. Chou, Roger et al. “Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society.” Annals of internal medicine vol. 147,7 (2007): 478-91. doi:10.7326/0003-4819-147-7-200710020-00006 Vitoula, Kristallia et al. “Behavioral Therapy Approaches for the Management of Low Back Pain: An Up-To-Date Systematic Review.” Pain and therapy vol. 7,1 (2018): 1-12. doi:10.1007/s40122-018-0099-4 Deyo, R A, and J N Weinstein. “Low back pain.” The New England journal of medicine vol. 344,5 (2001): 363-70. doi:10.1056/NEJM200102013440508 van Middelkoop, Marienke et al. “Exercise therapy for chronic nonspecific low-back pain.” Best practice & research. Clinical rheumatology vol. 24,2 (2010): 193-204. doi:10.1016/j.berh.2010.01.002

Achtsamkeit fördert unsere mentale – und auch unsere körperliche Gesundheit, sagen Diane Hielscher und Main Huong Nguyen. Wie das funktioniert? In dieser Folge Achtsam sprechen sie über die Zusammenhänge.**********An dieser Stelle findet ihr die Übung:00:44:00 - Achtsamkeitsübung mit Main Huong Nguyen**********Quellen aus der Folge:Farb, N. A., Segal, Z. V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., & Anderson, A. K. (2007). Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. Social cognitive and affective neuroscience, 2(4), 313-322. Lindahl, J. R., Fisher, N. E., Cooper, D. J., Rosen, R. K., & Britton, W. B. (2017). The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists. PloS one, 12(5), e0176239. Moffitt, R., Brinkworth, G., Noakes, M., & Mohr, P. (2012). A comparison of cognitive restructuring and cognitive defusion as strategies for resisting a craved food. Psychology & health, 27(sup2), 74-90. Heidenreich, T., & Michalak, J. (2007). Achtsamkeit und Akzeptanz: Opium für das Volk?. PiD-Psychotherapie im Dialog, 8(02), 194-195. **********Dianes und Main Huongs Empfehlungen:Harrer, M. E. & Weiss, H. (2015). Wirkfaktoren der Achtsamkeit: wie sie die Psychotherapie verändern und bereichern. Schattauer Verlag. **********Mehr zum Thema bei Deutschlandfunk Nova:Inneres Kind: Wie wir loslassen und nach vorne schauenBoreout: Achtsam mit Langeweile umgehenInterbeing: Achtsam mit der Welt in Beziehung leben**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de

We have a flipped episode this week with Sarah Stremming of Cog Dog Radio interviewing me. We're talking about the new paper out of the Dog Aging Project, "Lifetime Prevalence of Owner-Reported Medical Conditions in the 25 Most Common Dog Breeds in the Dog Aging Project Pack." There's been a lot of buzz on social media about this paper and we wanted to dig in to its findings. For those who saw our live Q&A about the paper, this interview covers very similar ground, although we go into some more detail. I'll include links to this study and others below, and if you want to ask questions about the paper, the Functional Breeding Facebook group is a great place to do it!   Forsyth, Kiersten K, et al. “Lifetime Prevalence of Owner-Reported Medical Conditions in the 25 Most Common Dog Breeds in the Dog Aging Project Pack.” Frontiers in Veterinary Science, vol. 10, 3 Nov. 2023. Original: https://doi.org/10.3389/fvets.2023.1140417 FDC summary: https://functionalbreeding.org/common-conditions-seen-in-primary-care-visits/    Do purebreds live longer? Yordy, J, et al. “Body size, inbreeding, and lifespan in domestic dogs”. Conserv. Genet. 21 (2020): 137-148. - https://functionalbreeding.org/inbreeding-depression-and-lifespan/ - “For a given body size category, mixed breed dogs lived on average 1.2 years longer than purebred ones.” Urfer, Silvan R., et al. "Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States." Canine medicine and genetics 7 (2020): 1-14. - https://link.springer.com/article/10.1186/s40575-020-00086-8 - DAP authors before DAP started - “We did not find significant differences in lifespan between purebred and mixed breed dogs; however, breeds with larger effective population sizes and/or lower inbreeding coefficients had median survival times 3–6 months longer than breeds with smaller effective population sizes or higher inbreeding coefficients” Mata, Fernando, and Andreia Mata. "Investigating the relationship between inbreeding and life expectancy in dogs: mongrels live longer than pure breeds." PeerJ 11 (2023): e15718. - https://peerj.com/articles/15718/?f...gzQO4ualQE4De4iuO6RmqokNKNTRYdxORkaYEMBwDx_0I - VetCompass data - “mongrel dogs had the highest life expectancy, followed by cross-bred dogs with only one purebred ancestor and purebred dogs had the lowest life expectancy” Increased inbreeding correlates to decreased lifespan Kraus C, et al. “How size and genetic diversity shape lifespan across breeds of purebred dogs”. GeroScience (2022). - https://functionalbreeding.org/size-genetic-diversity-lifespan/ Bannasch, D., Famula, T., Donner, J. et al. The effect of inbreeding, body size and morphology on health in dog breeds. Canine Genet Epidemiol 8, 12 (2021). - https://functionalbreeding.org/the-effect-of-inbreeding-body-size-and-morphology-on-health-in-dog-breeds/ Are there specific disorders of concern that are more common in purebreds? Bellumori, Thomas P., et al. "Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995–2010)." Journal of the American Veterinary Medical Association 242.11 (2013): 1549-1555. - https://avmajournals.avma.org/view/journals/javma/242/11/javma.242.11.1549.xml - UC Davis, 24 heritable (genetic) disorders - “Purebred dogs were more likely to have 10 genetic disorders, including dilated cardiomyopathy, elbow dysplasia, cataracts, and hypothyroidism. Mixed-breed dogs had a greater probability of ruptured cranial cruciate ligament.” Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 - “Mixed breed dogs were more likely to carry a common recessive disease, whereas purebreds were more likely to be genetically affected with one, providing DNA-based evidence for hybrid vigor.” (i.e. it isn't a problem if you don't inbreed on it)

Alok Kanojia, better known as Dr. K, is a charismatic psychiatrist and online streamer who offers a unique blend of psychological, self-help, and spiritual advice to guide individuals through the complexities of modern life, aiming to help them become Healthy Gamers™. Join Matt and Chris as they embark on a multi-part journey through the diverse biomes of Dr. K's content and try to ascertain the meta.In this first episode, Matt and Chris take a critical look at a 2019 video in which Dr. K discusses his views on Ayurvedic medicine, the problems with Western medicine, and the unacknowledged scientific evidence for Ayurvedic claims. We consider whether the evidence provided matches the rhetoric and relive youthful follies as we immerse ourselves in the all too familiar water of complementary and alternative medicine discourse.So join us as we learn about the universal mind and single type of depression proposed by modern medicine, how a tripartite classification is actually incredibly individualistic, how the shape of your nose and kink in your hair predicts the food you should eat and the quality of your bowel movements, and the surprising benefits of drinking elephant milk.In Part 2, we will delve into Dr. K's recent discussion/debate over Ayurvedic medicine with Dr. Mike, another popular YouTube doctor. And finally Part 3 will focus on the dynamics of Dr. K's long-form, somewhat controversial, mental health-themed interviews with influencers.Links Dr. K's Healthy Gamer GG websiteHealthy Gamer GG- Ayurveda Pt. 1: Gunas, Cognitive Fingerprint, PersonalityScience is Dope: Should we adopt Ayurveda | An Indian's response | Dr. Mike vs Dr. KList of Studies mentioned in the episodeSimon Singh's court case that Chris mentionedThe Iced Coffee Hour: Harvard Psychiatrist on How To Get Ahead of 99.9% of People (Starting NOW)Some of Matt's related papers: 1) Thomson, P., Jones, J., Browne, M., & Leslie, S. J. (2014). Why people seek complementary and alternative medicine before conventional medical treatment: a population-based study. Complementary therapies in clinical practice, 20(4), 339-346. & 2) Browne, M., Thomson, P., Rockloff, M. J., & Pennycook, G. (2015). Going against the herd: psychological and cultural factors underlying the ‘vaccination confidence gap'. PLoS one, 10(9), e0132562.

In this episode of the Epigenetics Podcast, we talked with Nadav Ahituv from University of California, San Francisco about his work on mutations of gene regulatory elements in human disease. Using massively parallel experiments, his lab revolutionized functional genomics by studying the impact of transcription factor binding sites on gene expression. His groundbreaking technology deciphered the regulatory language of gene expression by exploring transcription factor combinations, spacing, and orientation. By delving into the influence of DNA shape and gene topology, Nadav Ahituv's research provides a comprehensive understanding of gene regulation at the molecular level, shedding light on the complexity of genetic interactions. The conversation delves into specific cases involving enhancers, gene sequencing, and 3D genomic structure, highlighting the impact of critical elements such as CTCF sites on gene expression. Discussions of haploid insufficiency and its implications for human health, using CRISPR technology to enhance gene expression, offer new possibilities for treating genetic diseases. Explorations of leptin-responsive regulatory elements in the hypothalamus and liver-associated transcription factors provide insights into metabolic regulation and gene expression networks in different tissues. The episode also explores the epigenomic landscape, the evolution of methods from bulk approaches to single-cell analyses, and the role of AI and machine learning in deciphering complex genetic patterns. The conversation transitions to a unique study of bat embryonic development, dietary differences, and their implications for understanding wing development and metabolism in different bat species.   References Ahituv, N., Zhu, Y., Visel, A., Holt, A., Afzal, V., Pennacchio, L. A., & Rubin, E. M. (2007). Deletion of ultraconserved elements yields viable mice. PLoS biology, 5(9), e234. https://doi.org/10.1371/journal.pbio.0050234 Matharu, N., Rattanasopha, S., Tamura, S., Maliskova, L., Wang, Y., Bernard, A., Hardin, A., Eckalbar, W. L., Vaisse, C., & Ahituv, N. (2019). CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science (New York, N.Y.), 363(6424), eaau0629. https://doi.org/10.1126/science.aau0629 Ushiki, A., Zhang, Y., Xiong, C., Zhao, J., Georgakopoulos-Soares, I., Kane, L., Jamieson, K., Bamshad, M. J., Nickerson, D. A., University of Washington Center for Mendelian Genomics, Shen, Y., Lettice, L. A., Silveira-Lucas, E. L., Petit, F., & Ahituv, N. (2021). Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia. Nature communications, 12(1), 2282. https://doi.org/10.1038/s41467-021-22470-z Georgakopoulos-Soares, I., Deng, C., Agarwal, V., Chan, C. S. Y., Zhao, J., Inoue, F., & Ahituv, N. (2023). Transcription factor binding site orientation and order are major drivers of gene regulatory activity. Nature communications, 14(1), 2333. https://doi.org/10.1038/s41467-023-37960-5 Gordon, W. E., Baek, S., Nguyen, H. P., Kuo, Y. M., Bradley, R., Fong, S. L., Kim, N., Galazyuk, A., Lee, I., Ingala, M. R., Simmons, N. B., Schountz, T., Cooper, L. N., Georgakopoulos-Soares, I., Hemberg, M., & Ahituv, N. (2024). Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas. Nature communications, 15(1), 12. https://doi.org/10.1038/s41467-023-44186-y   Related Episodes Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel) Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Pedro Magno, Luisa Sousa e Caio Bastos falam de 4 clinicagens sobre magnésio: 1. Como investigar hipomagnesemia? 2. Magnésio e outros eletrólitos 3. Quando repor? 4. Como repor? Referências: 1. Zipursky, Jonathan et al. “Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study.” PLoS medicine vol. 11,9 e1001736. 30 Sep. 2014, doi:10.1371/journal.pmed.1001736 2. Cheungpasitporn, Wisit et al. “Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.” Medical sciences (Basel, Switzerland) vol. 8,3 37. 1 Sep. 2020, doi:10.3390/medsci8030037 3. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. Lancet. 1995;345(8951):669-685. 4. Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002;360(9341):1189-1196. doi:10.1016/s0140-6736(02)11278-5 5. Ray S, Park KW. Movement Disorders and Other Neurologic Impairment Associated With Hypomagnesemia: A Systematic Review. Neurol Clin Pract. 2023;13(6):e200202. doi:10.1212/CPJ.0000000000200202 6. De las Peñas R, Escobar Y, Henao F, Blasco A, Rodríguez CA; Spanish Society for Medical Oncology. SEOM guidelines on hydroelectrolytic disorders. Clin Transl Oncol. 2014;16(12):1051-1059. doi:10.1007/s12094-014-1234-2 7. Spichler A, Athanazio DA, Furtado J, Seguro A, Vinetz JM. Case report: severe, symptomatic hypomagnesemia in acute leptospirosis. Am J Trop Med Hyg. 2008;79(6):915-917. 8. Porath A, Mosseri M, Harman I, Ovsyshcher I, Keynan A. Dead Sea water poisoning. Ann Emerg Med. 1989;18(2):187-191. doi:10.1016/s0196-0644(89)80112-x 9. Wacker WE, Parisi AF. Magnesium metabolism. N Engl J Med. 1968;278(12):658-663. doi:10.1056/NEJM196803212781205

In this episode of the Joy Lab podcast, we're diving into the science and soul of 5-hydroxytryptophan (5-HTP), a supplement known for supporting mood through its role in serotonin production. We'll cover the basics of 5-HTP and its role in depression and anxiety along with the complex nature of depression and how 5-HTP might play a role in supporting mood (yeah, we'll even touch on the controversial serotonin hypothesis- we see you psychology and biology nerds!) Of course, since many of us want to know if supplementing with 5-HTP is helpful, we'll talk about the importance of quality in supplements, potential risks of serotonin syndrome, common 5-HTP dosages, and the nuanced approach needed when considering 5-HTP as part of mental health support.   Joy Lab and Natural Mental Health are community-supported. When you buy through the links below, we may earn a commission. That support helps keeps the Joy Lab podcast free for all!   Sources & Notes: Free Resilience Quiz and free Mini-Course: Take our Free Resilience Quiz and then sign up for your free Mini-Course to identify your mental health strengths and obstacles and take meaningful actions to support your resilience. Supplements noted (see where to shop below): NeuroMood Pure Pack (this is our favorite mood-supporting packet that includes vitamins, minerals, EFAs, curcumin, and amino acids [with 50 mg 5-HTP]) NeuroCalm (a blend that includes 5-HTP to support production of calming neurotransmitters)  Liposomal NeuroCalm (same as above, just liposomal delivery) CereVive (includes amino acid precursors and bioactive nutrients that support healthy levels of neurotransmitters) Cerenity (comprehensive formula designed to address daily stress by increasing the production of the calming neurotransmitters serotonin and gamma-amino butyric acid) Cerenity PM (an alternative if sleep is also an issue) 5-HTP Synergy (this can be a good option for those who do not want a product that includes additional ingredients) Where to shop: Our partner store at Fullscript: This is where you can find high-quality supplements and wellness products. Except for our CBD Gummies, any product links mentioned in the show notes below will require an account. Sign up for your free Fullscript account. Resilient Remedies: This is where you can find our line of trusted, high-quality CBD gummies: https://www.resilientremedies.com/ Read more at the NMH blog: 5-HTP for Anxiousness  Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Your Joy Lab membership also includes our NMH Community! NMH Community: Access lots of extra resilience-boosting resources AND join a group of inspiring folks who play an integral role in keeping this podcast going.  Blaze J. (2021). A Comparison of Current Regulatory Frameworks for Nutraceuticals in Australia, Canada, Japan, and the United States. Innovations in pharmacy, 12(2), 10.24926/iip.v12i2.3694. https://doi.org/10.24926/iip.v12i2.3694 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326690/  Lacasse, J. R., & Leo, J. (2005). Serotonin and depression: a disconnect between the advertisements and the scientific literature. PLoS medicine, 2(12), e392. https://doi.org/10.1371/journal.pmed.0020392  Joy Lab Podcast #127: Lithium Orotate & Lithium Carbonate Subscribe to our Newsletter: Join us at NaturalMentalHealth.com for exclusive emails, updates, and additional strategies. “We are not our trauma. We are not our brain chemistry. That's part of who we are, but we're so much more than that.” Sam Miller (visit their website). Check out our favorite resilience-boosting reads at Bookshop.org Full transcript here. This content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program.See our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.  

Living with an autoimmune disease can often feel overwhelming, as though you have little control over your body's reactions. Many people believe they are powerless in the face of autoimmune diseases.. However, adopting specific lifestyle changes can significantly improve your overall well-being, reduce symptoms, and minimize the need for medication.  In today's episode Miles Hassel, MD explores:  The therapeutic applications of lifestyle choices in managing autoimmune diseases and steps you can take to regain control over your health. Exercise and how it helps to reduce inflammation and can improve your overall quality of life. Find an activity you enjoy, whether it's walking, yoga, swimming, or strength training, and make it a regular part of your routine. The Mediterranean diet and how it's shown to reduce inflammation and improve symptoms in people with autoimmune diseases. If you have an autoimmune disease, you have more power than you might think to influence your health. By adopting a proactive and positive approach to your lifestyle, you can help your immune system function better, reduce symptoms, and improve your overall quality of life.  Start with small changes, stay committed, and believe in your body's ability to heal and thrive.   Resources for Today's Episode: Aya, V., et al.. (2021). Association between physical activity and changes in intestinal microbiota composition: A systematic review. PloS one, 16(2), e0247039. https://doi.org/10.1371/journal.pone.0247039 Johnson SJ, Miles Hassell MD, Martin H. The short of breath and sweaty principle: Risk reduction therapies available to everyone. J Clin Nur Rep 1 (1), 11. 2022 Oct 10;12. Bieber, K., et al. (2023). Autoimmune pre-disease. Autoimmunity reviews, 22(2), 103236 https://pubmed.ncbi.nlm.nih.gov/36436750/ Li, Z., and Wang, X. (2022) Clin. Effect and biol mech of exercise for RA: Mini-review. Frontiers in Immunology, 13(5). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852831/ Jiang, Y., et al. (2021). (2021). Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases. Nutrients, 13(3), 890. https://doi.org/10.3390/nu13030890. https://pubmed.ncbi.nlm.nih.gov/33801883/ Join the cause! Support the podcast and be a champion of a future episode by donating here: https://greatmed.org/donate/   For more information and references head to: https://greatmed.org/cold-flu/have-fewer-sick-days/    

In this episode of the Epigenetics Podcast, we talked with Ana Cvejic from the Biotech Research & Innovation Centre at the University of Copenhagen about her work on using sc-multiomics to characterise human developmental hematopoiesis. The conversation starts by delving into Ana's research on hematopoiesis, starting with her work on identifying novel genes controlling blood traits in zebrafish models. She explains her transition to single-cell methodologies and the application of single-cell RNA sequencing to study hematopoietic cells in zebrafish, focusing on thrombocyte lineage commitment and gene expression. The discussion progresses to her groundbreaking study on human fetal hematopoiesis, where she combined single-cell RNA-seq with single-cell ATAC-seq to understand chromatin accessibility and gene expression dynamics. Ana then shares insights into the identification of new cell surface markers and the priming of hematopoietic stem cells, particularly in conditions like Down syndrome. Furthermore, she then elaborates on the construction of a phylogenetic tree of blood development using whole-genome sequencing of single-cell-derived hematopoietic colonies from healthy human fetuses. She explains the motivation behind this study, highlighting the insights gained regarding stem cell quantities, developmental timelines, and mutations in blood development. References Bielczyk-Maczyńska, E., Serbanovic-Canic, J., Ferreira, L., Soranzo, N., Stemple, D. L., Ouwehand, W. H., & Cvejic, A. (2014). A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. PLoS genetics, 10(7), e1004450. https://doi.org/10.1371/journal.pgen.1004450 Athanasiadis, E. I., Botthof, J. G., Andres, H., Ferreira, L., Lio, P., & Cvejic, A. (2017). Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Nature communications, 8(1), 2045. https://doi.org/10.1038/s41467-017-02305-6 Ranzoni, A. M., Tangherloni, A., Berest, I., Riva, S. G., Myers, B., Strzelecka, P. M., Xu, J., Panada, E., Mohorianu, I., Zaugg, J. B., & Cvejic, A. (2021). Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis. Cell stem cell, 28(3), 472–487.e7. https://doi.org/10.1016/j.stem.2020.11.015   Related Episodes Single Cell Epigenomics in Neuronal Development (Tim Petros) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro) Single-Cell Technologies using Microfluidics (Ben Hindson)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In our latest podcast episode, we delve into a story of transition, courage, and the unwavering human spirit as our guest, Yasir Essar, swapped his dentistry scrubs for a career in public health amid the chaotic backdrop of a global pandemic and geopolitical turmoil. Yasir shares how visualizing achievements can provide a push to overcome challenges and demonstrates the powerful role mentors and community support play in guiding career paths, particularly for international students and professionals in new environments. His career transformation teaches us that with resilience, the right mindset, and community support, we can navigate through uncertainty and emerge with renewed purpose and aspirations.You'll LearnHow the COVID pandemic led Yasir to public and global health and steps he took to transition into the field from dentistryYasir's experience continuing his education and career as a refugee in Canada, how he persevered through the uprooting of his life, and how his background shaped his current interest in refugee and global healthBuilding and relying on a social support group and mentors to achieve your dreams and other ways to visualize your goalsTips for international students and remembering to take the time to care for yourself in a new countryUsing LinkedIn with intentionality as a tool to network, facilitate advocacy, tell stories, and make an impactToday's GuestYasir is a former refugee from Afghanistan who holds an MSc in Global Health from McMaster University.Prior to moving to Canada, he lived as a refugee in Tajikistan after fleeing Afghanistan. During his time as a refugee, he continued to share his lived experience of refugee life.Currently, he works as a Research Assistant at Western University in the Department of Epidemiology and Biostatistics, and as a Community Scholar at the University of Calgary. Additionally, he holds a visiting academic position with the Faculty of Medicine at the University of Southampton. Yasir's professional journey is marked by an unwavering commitment to knowledge and a passion for making a real-world impact. His scholarly work has been published in prestigious journals such as The Lancet, BMJ, and PLoS. He is also a certified Project Management Professional (PMP®) and holds multiple certificates from Wayne State University, the University of Geneva, McGill University, and the LinkedIn Learning Academy.During his tenure as a Research Assistant at the Research Institute of the McGill University Health Center, he focused particularly on tuberculosis research, further enriching his expertise in infectious disease research.Yasir is always eager to connect with like-minded professionals, share insights, and explore collaborative opportunities. He is open to guest lecture invitations on the topics of refugees, mentorship, and global health.ResourcesConnect with Yasir on LinkedIn  Support the Show.Join The Public Health Career Club: the #1 hangout spot and community dedicated to building and growing your dream public health career.

How can marmosets inform human birth experiences? Are there really four types of human pelvises? What happens when primates birth litters? Prof. Julienne Rutherford joins Chris and Eric to answer these questions and more! Find the articles discussed on this episode via the following citations: Rutherford, J.N., Ross, C.N., Ziegler, T., Burke, L.A., Steffen, A.D., Sills, A., Layne Colon, D., Demartelly, V.A., Narapareddy, L.R. and Tardif, S.D., 2021. Womb to womb: Maternal litter size and birth weight but not adult characteristics predict early neonatal death of offspring in the common marmoset monkey. Plos one, 16(6), p.e0252093. VanSickle, C., Liese, K.L. and Rutherford, J.N., 2022. Textbook typologies: challenging the myth of the perfect obstetric pelvis. The Anatomical Record, 305(4), pp.952-967. ---------------------------------------------------- Dr. Julienne Rutherford is Professor and John & Nell Mitchell Endowed Chair for Pediatric Nursing in the University of Arizona College of Nursing. She is a biological anthropologist whose work integrates bioanthropological theory with biomedical science. For 20 years, she has sustained a program of research exploring the intrauterine environment as a biosocial determinant of health. She studies how maternal life history and lived experience shape this earliest developmental setting, and how, in turn, the intrauterine environment influences growth, health, and development across the life course and across generations. ---------------------------------------------------- Contact the Sausage of Science Podcast and Human Biology Association: Facebook: www.facebook.com/groups/humanbiologyassociation Website: humbio.org/, Twitter: @HumBioAssoc Chris Lynn, HBA Public Relations Committee Chair Website: cdlynn.people.ua.edu/, E-mail: cdlynn at ua.edu, Twitter:@Chris_Ly Eric Griffith, HBA Junior Fellow, SoS producer E-mail: eric.griffith at duke.edu

Die Atmung begleitet uns unser ganzes Leben. Sich mit diesem Thema zu beschäftigen ist daher wichtig und interessant zugleich. Sinja und Boris ergründen in dieser Folge, was genau beim Atmen passiert, welche Auswirkungen dies auf unsere Psyche hat und welche Rolle der Atem bei Meditation und Achtsamkeit hat.Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier.Hintergründe und Studien:Homma, I., & Masaoka, Y. (2008). Breathing rhythms and emotions. Experimental Physiology, 93. Link zur Studie Bernardi, L., Sleight, P., Bandinelli, G., Cencetti, S., Fattorini, L., Wdowczyc-Szulc, J., & Lagi, A. (2001). Effect of rosary prayer and yoga mantras on autonomic cardiovascular rhythms: comparative study. BMJ : British Medical Journal, 323, 1446 - 1449. Link zur Studie Fitzpatrick, M., McLean, H., Urton, A., Tan, A., O'Donnell, D., & Driver, H. (2003). Effect of nasal or oral breathing route on upper airway resistance during sleep. European Respiratory Journal, 22, 827 - 832. Link zur Studie Nestor, J. (2020). Breath: The new science of a lost art. Riverhead Books Link zum Buch Woda, A., Foster, K., Foster, K., Mishellany, A., & Peyron, M. (2006). Adaptation of healthy mastication to factors pertaining to the individual or to the food. Physiology & Behavior, 89, 28-35. Link zur Studie Lehrer, P., Kaur, K., Sharma, A., Shah, K., Huseby, R., Bhavsar, J., & Zhang, Y. (2020). Heart rate variability biofeedback improves emotional and physical health and performance: A systematic review and meta analysis. Applied psychophysiology and biofeedback, 45, 109-129. Link zur Studie Vaschillo, E. G., Vaschillo, B., Buckman, J. F., Nguyen-Louie, T., Heiss, S., Pandina, R. J., & Bates, M. E. (2015). The effects of sighing on the cardiovascular system. Biological psychology, 106, 86-95. Link zur Studie Vlemincx, E., Van Diest, I., & Van den Bergh, O. (2016). A sigh of relief or a sigh to relieve: the psychological and physiological relief effect of deep breaths. Physiology & behavior, 165, 127-135. Link zur Studie Ahmed, A., Devi, R. G. and Priya, A. J. (2021) “Effect of Box Breathing Technique on Lung Function Test”, Journal of Pharmaceutical Research International, 33(58A), pp. 25–31. Link zur StudieAndas, A. M., bin Sansuwito, T., Said, F. M., Puspitasari, I., Prima, A., & Andas, N. H. (2023). The Effect of Box Breathing on Sleep Disorders in Elderly at Tresna Werdha Social Institution. Malaysian Journal of Medicine & Health Sciences, 19. Link zur Studie Kozhevnikov, M., Elliott, J., Shephard, J., & Gramann, K. (2013). Neurocognitive and somatic components of temperature increases during g-tummo meditation: legend and reality. PloS one, 8(3), e58244. Link zur Studie Hof, W., & Ohno, A. A. (2020). The Wim Hof method: activate your full human potential. Louisville, CO: Sounds True Link zum Buch Almahayni, O., & Hammond, L. (2024). Does the Wim Hof Method have a beneficial impact on physiological and psychological outcomes in healthy and non-healthy participants? A systematic review. Plos one, 19(3), e0286933. Link zur Studie Rock, A. J., Denning, N. C., Harris, K. P., Clark, G. I., & Misso, D. (2015). Exploring holotropic breathwork: An empirical evaluation of altered states of awareness and patterns of phenomenological subsystems with reference to transliminality. Journal of Transpersonal Psychology, 47(1). Link zur Studie Rhinewine, J. P., & Williams, O. J. (2007). Holotropic breathwork: The potential role of a prolonged, voluntary hyperventilation procedure as an adjunct to psychotherapy. The journal of alternative and complementary medicine, 13(7), 771-776. Link zur Studie Metcalf, B. A. (1995). Examining the effects of Holotropic Breathwork in the recovery from alcoholism and drug dependence. Center for Transpersonal Studies & Development. Link zur Studie Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

In this episode of the Epigenetics Podcast, we talked with Mark Parthun from Ohio State University about his work on the role of Hat1p in chromatin assembly. Mark Parthun shares insights into his pivotal paper in 2004 that explored the link between type B histone acetyltransferases and chromatin assembly, setting the stage for his current research interests in epigenetics. He highlights the role of HAT1 in acetylating lysines on newly synthesized histones, its involvement in double-strand break repair, and the search for phenotypes associated with HAT1 mutations. The discussion expands to a collaborative research project between two scientists uncovering the roles of HAT1 and NASP as chaperones in chromatin assembly. Transitioning from yeast to mouse models, the team investigated the effects of HAT1 knockout on mouse phenotypes, particularly in lung development and craniofacial morphogenesis. They also explored the impact of histone acetylation on chromatin dynamics and its influence on lifespan, aging processes, and longevity.   References Parthun, M. R., Widom, J., & Gottschling, D. E. (1996). The Major Cytoplasmic Histone Acetyltransferase in Yeast: Links to Chromatin Replication and Histone Metabolism. Cell, 87(1), 85–94. https://doi.org/10.1016/S0092-8674(00)81325-2 Kelly, T. J., Qin, S., Gottschling, D. E., & Parthun, M. R. (2000). Type B histone acetyltransferase Hat1p participates in telomeric silencing. Molecular and cellular biology, 20(19), 7051–7058. https://doi.org/10.1128/MCB.20.19.7051-7058.2000 Ai, X., & Parthun, M. R. (2004). The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Molecular cell, 14(2), 195–205. https://doi.org/10.1016/s1097-2765(04)00184-4 Nagarajan, P., Ge, Z., Sirbu, B., Doughty, C., Agudelo Garcia, P. A., Schlederer, M., Annunziato, A. T., Cortez, D., Kenner, L., & Parthun, M. R. (2013). Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS genetics, 9(6), e1003518. https://doi.org/10.1371/journal.pgen.1003518 Agudelo Garcia, P. A., Hoover, M. E., Zhang, P., Nagarajan, P., Freitas, M. A., & Parthun, M. R. (2017). Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly. Nucleic Acids Research, 45(16), 9319–9335. https://doi.org/10.1093/nar/gkx545 Popova, L. V., Nagarajan, P., Lovejoy, C. M., Sunkel, B. D., Gardner, M. L., Wang, M., Freitas, M. A., Stanton, B. Z., & Parthun, M. R. (2021). Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Research, 49(21), 12136–12151. https://doi.org/10.1093/nar/gkab1044   Related Episodes Regulation of Chromatin Organization by Histone Chaperones (Geneviève Almouzni) Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David) scDamID, EpiDamID and Lamina Associated Domains (Jop Kind)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

One-off learning interventions are frequently the ‘go to' solution for workplace learning teams, but we know that spaced repetition and retrieval practice are more effective. How do we get past organizational constraints that make this difficult? In this week's episode of The Mind Tools L&D Podcast, Tony Manwani from People Unboxed joins Ross Dickie and Ross Garner to discuss: ·       The problems with one-off interventions ·       Science-backed principles to make an impact ·       How Tony's ‘BentoBot' tool puts those principles into practice. For a recent replication of Ebbinghaus' ‘forgetting curve' experiment, see: Murre, J. M., & Dros, J. (2015). Replication and analysis of Ebbinghaus' forgetting curve. PloS one, 10(7), e0120644. For more on the ‘Leitner system' see the overview on Wikipedia. For the LTEM model, referenced by Ross D, see Dr Will Thalheimer's website. In ‘What I Learned This Week', Ross G recommended Perplexity.ai. For more from us, including access to our back catalogue of podcasts, visit mindtools.com/business. There, you'll also find details of our award-winning performance support toolkit, our off-the-shelf e-learning, and our custom work.   For more from Tony and People Unboxed, see peopleunboxed.co.uk. For BentoBot, see bentobot.com. Connect with our speakers    If you'd like to share your thoughts on this episode, connect with our speakers: ·       Ross Garner ·       Ross Dickie ·       Tony Manwani

Did you know that your gut health has an impact on your mental health? A far greater one than you may realize. Research shows that the microbiota living in your gut communicates with neurotransmitters in your brain and vice versa via the vagus nerve. Watch this video to learn about the foods you should avoid if you have depression. We also made another video on the foods you should avoid if you have anxiety: https://youtu.be/UzHQeqhIgF0 Writer: Sara Del Villar Script Editor: Caitlin McColl Script Manager: Kelly Soong VO: Amanda Silvera Animator: Aury YouTube Manager: Cindy Cheong REFERENCES: Collins, R., & Legg, T. J. (2017, February 8). Depression & DIET: 6 foods that fight depression. Healthline. www.healthline.com/health/depression/diet. Eat This Not That! Editors. (2020, April 27). 15 worst foods for anxiety or depression. Eat This Not That. https://www.eatthis.com/foods-make-anxiety-worse/. Gangwisch, J. E., Hale, L., Garcia, L., Malaspina, D., Opler, M. G., Payne, M. E., Rossom, R. C., & Lane, D. (2015). High glycemic index diet as a risk factor for depression: analyses from the Women's Health Initiative. The American journal of clinical nutrition, 102(2), 454–463. doi.org/10.3945/ajcn.114.103846 Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007). Intense sweetness surpasses cocaine reward. PloS one, 2(8), e698. doi.org/10.1371/journal.pone.0000698 Maher, T. J., & Wurtman, R. J. (1987). Possible neurologic effects of aspartame, a widely used food additive. Environmental health perspectives, 75, 53–57. doi.org/10.1289/ehp.877553 Pattemore, C. (2021, June 4). 8 foods that may cause depression. Psych Central. psychcentral.com/depression/foods-that-cause-depression. Reardon, S. (2014, November 12). Gut–brain link grabs neuroscientists. Nature News. https://www.nature.com/articles/515175a. Strawbridge, H. (2020, January 29). Artificial sweeteners: Sugar-free, but at what cost? Harvard Health. www.health.harvard.edu/blog/artificial-sweeteners-sugar-free-but-at-what-cost-201207165030. Tandel K. R. (2011). Sugar substitutes: Health controversy over perceived benefits. Journal of pharmacology & pharmacotherapeutics, 2(4), 236–243. https://doi.org/10.4103/0976-500X.85936 Tello, M. (2020, January 29). Diet and depression. Harvard Health. www.health.harvard.edu/blog/diet-and-depression-2018022213309

Tortoises return to an island in the Galapagos and prove themselves to be solid ecosystem engineers. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Tapia Aguilera W, Gibbs JP. 2023. Rewilding giant tortoises engineers plant communities at local to landscape scales. Conservation Letters 16:e12968. DOI: 10.1111/conl.12968. Other Mentioned Papers/Studies: Loconsole M, Stancher G, Versace E. 2023. Crossmodal association between visual and acoustic cues in a tortoise (Testudo hermanni). Biology Letters 19:20230265. DOI: 10.1098/rsbl.2023.0265. Starck, J. M., Schrenk, F., Schröder, S., & Pees, M. (2022). Malformations of the sacculus and the semicircular canals in spider morph pythons. Plos one, 17(8), e0262788. Other Links/Mentions: Scinax crospedospilus by Mario Sacramento from https://amphibiaweb.org/cgi/amphib_query?where-genus=Scinax&where-species=crospedospilus Charles Darwin Foundation. Studying the ecology and distribution of the invasive treefrog Scinax quinquefasciatus https://www.darwinfoundation.org/en/research/projects/invasive-treefrog Editing and Music: Podcast edited by Emmy – https://www.fiverr.com/emmyk10  Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Caecilians, the strange underground amphibians, are known to let their babies eat their skin. But the full benefits of this practice are only now becoming clear. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Kouete MT, Bletz MC, LaBumbard BC, Woodhams DC, Blackburn DC. 2023. Parental care contributes to vertical transmission of microbes in a skin-feeding and direct-developing caecilian. Animal Microbiome 5:28. DOI: 10.1186/s42523-023-00243-x. Species of the Bi-Week: Li S-Z, Liu J, Ke X-C, Cheng G, Wang B. 2024. A new species of Amolops (Amphibia, Anura, Ranidae) from Guizhou Province, China. ZooKeys 1189:33–54. DOI: 10.3897/zookeys.1189.115621. Other Mentioned Papers/Studies: Starck, J. M., Schrenk, F., Schröder, S., & Pees, M. (2022). Malformations of the sacculus and the semicircular canals in spider morph pythons. Plos one, 17(8), e0262788. Editing and Music: Podcast edited by Emmy – https://www.fiverr.com/emmyk10  Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Daylight saving time. When it happens twice a year, do you find yourself forgetting which one is the “bad one”? We know “spring forward, fall back”, and the “spring forward” part sounds deceptively perky and positive, but really it's the BAD ONE! Meaning, we lose an hour by shifting the clock forward. What a crock! Our circadian rhythms are so interesting, and drive so many facets of our physical and mental health. A recent article posted by Rush University Medical Center highlighted the detrimental effects that spring daylight saving time can wreak on our bodies and minds. The article features sleep medicine specialist, James Wyatt, PhD (who coincidentally taught Jeremy and Julie about sleep medicine in medical school!), who explains how the sleep science community recognizes the research-backed hypothesis that daylight saving time poses risks to our health. While the American Academy of Sleep Medicine, as well as more than a dozen other organizations, publicly recognize that public health and safety would benefit from the elimination of daylight saving time, there's no way to know if the policy will ever change in the US. So, since we are forced to “spring forward” this Sunday, March 10th, we decided to devote an episode to how the time shift affects us, and if we can take steps to mitigate the disruption we feel during daylight saving time! Also, enjoy a little dessert story, brought to our attention by our friends from the Bananas podcast, Kurt Braunohler and Scotty Landes, where we discuss the "VIBES pill", an ingestible motorized vibrating pill currently under research, that, when ingested before a meal, mimics the feeling of fullness. What a strange world we live in, folks! So, friends, are you ready to spring into action?? Resources for today's episode include: A Rush Stories article titled "Dreading the Spring Forward? You're Not Alone." A Johns Hopkins article titled "7 Things to Know About Daylight Savings Time." The American Academy of Sleep Medicine 2019 Sleep Prioritization Study results. A Science Daily article highlighting a study by the American Academy of Neurology, titled "Does daylight saving time increase risk of stroke?" A PLOS article titled "Measurable health effects associated with the daylight saving time shift." A 2018 article from The Energy Journal, titled "Does Daylight Saving Save Electricity? A Meta-Analysis." A December 2023 article in Science Advances titled "A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety." Link to the Bananas podcast (the Jan 30th, 2024 episode includes the VIBES pill story :) Thanks for tuning in, folks! Please sign up for our "PULSE CHECK" monthly newsletter! Signup is easy, right on our website page, and we PROMISE we will not spam you! We just want to send you cool articles, videos and thoughts :) For more episodes, limited edition merch, or to become a Friend of Your Doctor Friends (and more), follow this link!   Find us at: Website: yourdoctorfriendspodcast.com  Email: yourdoctorfriendspodcast@gmail.com  Connect with us: @your_doctor_friends (IG) Send/DM us a voice memo/question and we might play it on the show! @yourdoctorfriendspodcast1013 (YouTube) @JeremyAllandMD (IG, FB, Twitter) @JuliaBrueneMD (IG) @HealthPodNet (IG)

Découvrez le LIVRE Neurosapiens ! Pour apprendre à créer rapidement et à moindre coût son podcast, c'est par ici ! Aujourd'hui je vous partage des méthodes de travail issues des recherches en psychologie et cognition pour améliorer vos révisions et votre organisation, et attaquer le semestre de façon plus sereine. Recherches et écriture : Thaïs MarquesAnimation & réalisation : Anaïs RouxProduction : Anaïs Roux & Lacmé ProductionInstagram : https://www.instagram.com/neurosapiens.podcast/Pour m'écrire : neurosapiens.podcast@gmail.comAudio : Play-Doh meets Dora - Carmen María and Edu EspinalGood times - Patrick Patrikios.Références Karpicke, J. D., & Roediger III, H. L. (2008). The critical importance of retrieval for learning. science, 319(5865), 966-968.Psychological Correlates of University Students' Academic Performance: A Systematic Review and Meta-Analysis (Richardson et al., 2012) Improving Students' Learning With Effective Learning Techniques: Promising Directions From Cognitive and Educational Psychology (Dunlosky et al., 2013)- Neural mechanisms of mental fatigue (Ishii et al., 2014)Albulescu, P., Macsinga, I., Rusu, A., Sulea, C., Bodnaru, A., & Tulbure, B. T. (2022). " Give me a break!" A systematic review and meta-analysis on the efficacy of micro-breaks for increasing well-being and performance. Plos one, 17(8), e0272460.- Long-Term Effects of Attentional Performance on Functional Brain Network Topology (Breckel et al., 2013)- Spatially Distributed Effects of Mental Exhaustion on Resting-State FMRI Networks (Esposito et al., 2014)Investigating the testing effect: Retrieval as a characteristic of effective study strategies (Bae & al., 2019)Rethinking the Use of Tests: A Meta-Analysis of Practice Testing (Adesope & al., 2017)The Effect of Testing Versus Restudy on Retention: A Meta-Analytic Review of the Testing Effect (Rowland 2014)

In this program, we compare dreaming and improvisation focusing on creative synergies, experiential similarities, and the underlying neurophysiology. These states of mind are mutually illuminating. That is, learning about one provides insights into the other. A key insight here is that we can deepen our understanding of improvisation by exploring other states of mind that have overlapping experiential qualities or brain states. In his book Dreams of Awakening, Charlie Morley writes that “…there are many different ways to tell the difference between [different states of experience], but the easiest way to get to grips with these differences is to spend as much time as we can in these states.” I propose that this is the case for improvisation, as well. By paying more attention to our dreaming experiences, we may deepen our knowledge of the experience of improvisation. References: The Case of the Three-Sided Dream: https://tv.apple.com/us/movie/the-case-of-the-three-sided-dream/umc.cmc.2no74bniyii0qtz63oc0wrmih Bashwiner, D. (2018). The neuroscience of musical creativity. The Cambridge Handbook of the neuroscience of creativity, 51, 495-516. Link to Albert Ayler's New Grass liner notes: https://lavelleporter.com/2010/08/22/message-from-albert-ayler/ I Called Him Morgan documentary: https://tv.apple.com/us/movie/i-called-him-morgan/umc.cmc.4cip1f47gqxk6qigg0mb1hiny Arrows to Infinity documentary: https://tv.apple.com/us/movie/charles-lloyd-arrows-into-infinity/umc.cmc.3ldicyne96kj1hrewd9w3dmvj Kansas City PBS documentary Bird: Not Out Of Nowhere | Charlie Parker's Kansas City Legacy: https://www.youtube.com/clip/Ugkx9Z02xiRacQxWEtx5eSmeucx-t6lB5kYZ Zadra, A., & Stickgold, R. (2021). When brains dream: Understanding the science and mystery of our dreaming minds. WW Norton & Company. Oliver Sach's article about the jazz drummer with Tourette's Syndrome: https://medhum.med.nyu.edu/view/12034 Hank Green of the SciShow Psych: https://www.youtube.com/watch?v=KwOhfmygHyM Braun, A. R., Balkin, T. J., Wesenten, N. J., Carson, R. E., Varga, M., Baldwin, P., ... & Herscovitch, P. (1997). Regional cerebral blood flow throughout the sleep-wake cycle. An H2 (15) O PET study. Brain: a journal of neurology, 120(7), 1173-1197. Kraehenmann, R. (2017). Dreams and psychedelics: neurophenomenological comparison and therapeutic implications. Current neuropharmacology, 15(7), 1032-1042. Limb, C. J., & Braun, A. R. (2008). Neural substrates of spontaneous musical performance: An fMRI study of jazz improvisation. PLoS one, 3(2), e1679. Liu, S., Chow, H. M., Xu, Y., Erkkinen, M. G., Swett, K. E., Eagle, M. W., ... & Braun, A. R. (2012). Neural correlates of lyrical improvisation: an fMRI study of freestyle rap. Scientific reports, 2(1), 834. Rosen, D. S., Oh, Y., Erickson, B., Zhang, F. Z., Kim, Y. E., & Kounios, J. (2020). Dual-process contributions to creativity in jazz improvisations: An SPM-EEG study. NeuroImage, 213, 116632. Walker, M. P., & van Der Helm, E. (2009). Overnight therapy? The role of sleep in emotional brain processing. Psychological bulletin, 135(5), 731. Trehub, S. E., Ghazban, N., & Corbeil, M. (2015). Musical affect regulation in infancy. Annals of the New York Academy of Sciences, 1337(1), 186-192. Shenfield, T., Trehub, S. E., & Nakata, T. (2003). Maternal singing modulates infant arousal. Psychology of music, 31(4), 365-375. Terry, P. C., Karageorghis, C. I., Curran, M. L., Martin, O. V., & Parsons-Smith, R. L. (2020). Effects of music in exercise and sport: A meta-analytic review. Psychological bulletin, 146(2), 91. Seppälä, E., Bradley, C., & Goldstein, M. R. (2020). Research: Why breathing is so effective at reducing stress. Harvard Business Review. Diakses dari https://hbr. org/2020/09/research-why-breathing-is-so-effective-at-reducing-stress. https://hbr.org/2020/09/research-why-breathing-is-so-effective-at-reducing-stress

This time the focus is on selling property for more money in the current buyer's market using Purchase Lease Options (PLOs). Simon discusses how landlords can benefit from selling properties to tenant buyers, highlighting the advantages of maximising revenue from the sale while eliminating the hassle of property management.  KEY TAKEAWAYS Selling property to tenant buyers using Purchase Lease Options (PLOs) can be a lucrative strategy for maximising revenue from a property sale. Landlords who no longer want to deal with the hassle of owning a property but do not need immediate funds can benefit from selling through PLOs. Tenant buyers are individuals eager to get on the property ladder but may not qualify for a mortgage immediately, making them ideal candidates for PLO agreements. Tenant buyers pay an upfront option fee, demonstrating their commitment to purchasing the property in the future. Finding tenant buyers can be done through various methods, such as signage, leaflet distribution, and collaboration with mortgage brokers specialising in first-time buyers. BEST MOMENTS "By selling the property on a purchase lease option to a tenant buyer, there are many benefits. First of all, they get rid of the hassle, and that can be very quickly." "Most landlords, when selling a property, they want to get as much as they can from that property, but they don't necessarily need the money now." "So how do we find these people? Well, there are lots of ways. First of all, you can always put up a sign in the window of the property or outside the property saying something like, why rent when you can buy?" "And for the landlord who doesn't want their property anymore, They want to sell but don't need the money right now. Putting a tenant buyer into that property could be a great solution." VALUABLE RESOURCES To secure a complementary copy of the chapter on "How to sell to Tenant Buyers from Simon's new book Lease Options Magic visit https://www.leaseoptionsmagic.co.uk/SellPLO To attend your first pin meeting as Simon's guest visit http://www.pinmeeting.co.uk/, find your local meeting, and at the bottom of the page where you normally pay £20, click on where is says "pay with a voucher code" and use this code: PODCAST. This will by pass the payment page and you can attend your first pin meeting for free. Property Magic: How to Buy Property Using Other People's Time, Money and Experience by Simon Zutshi To find your local pin meeting visit: www.PinMeeting.co.uk and use voucher code PODCAST to attend you first meeting as Simon's guest (instead of paying the normal £20). Register at Mindset For Property at - www.mindsetforproperty.co.uk  Contact and follow Simon here: Facebook: http://www.facebook.com/OfficialSimonZutshi  LinkedIn: https://www.linkedin.com/in/simonzutshi/ YouTube: https://www.youtube.com/SimonZutshiOfficial Twitter: https://twitter.com/simonzutshi Instagram: https://www.instagram.com/simonzutshi/ Simon Zutshi, experienced investor, successful entrepreneur and best-selling author, is widely recognised as one of the top wealth creation strategists in the UK. Having started to invest in property in 1995 and went on to become financially independent by the age of 32. Passionate about sharing his experience, Simon founded the property investor's network (pin) in 2003 www.pinmeeting.co.uk.    pin has since grown to become the largest property networking organisation in the UK, with monthly meetings in 50 cities, designed specifically to provide a supportive, educational and inspirational environment for people like you to network with and learn from other successful investors. Since 2003, Simon has taught thousands of entrepreneurs and business owners how to successfully invest in a tax-efficient way.  How to create additional streams of income, give them more time to do the things they want to do and build their long-term wealth. Simon's book “Property Magic” which is now in its sixth edition, became an instant hit when first released in 2008 and remains an Amazon No 1 best-selling property book. Simon launched his latest business, www.CrowdProperty.com, in 2014, which is an FCA Regulated peer to peer lending platform to facilitate loans between private individuals and property professionals.

The gang discusses two papers that look at Mesozoic tracks that may or may not have been made by an avian archosaur. Meanwhile, Curt becomes activated, Amanda has to deal with harsh truths, James gets creative with taxon names, and everyone get distracted very quickly. (Editor's Note: If you want to just “get to the science” skip to 11 minutes in. We hadn't talked in 2 months and it shows. I just didn't have the heart to cut all of it)   Up-Goer Five (Curt Edition): The friends look at two papers that look at foot falls in the ground from a very very long time ago which may or may not be made by animals that can fly through the sky, or may have been made by big angry animals. The problem is that big angry animals and the animals that can fly are very close to each other, and their foot falls can look a lot like each other. The first paper looks at some very old foot falls and some of these foot falls do look like they were made by animals that can fly, but that would be very very strange because it would need a lot of other things to be true if that were true. They say that there was something moving like these animals today that can fly but were probably not those types of animals, but it shows how hard it can be to see if these foot falls were made by these animals that can fly. The second paper uses numbers to try and see if we can really see if some of these foot falls were made by animals that fly. What they find is that we have used how big these foot falls are as a reason why we think some are from big angry animals and some are from animals that can fly. This is maybe a problem because we know there are small big angry animals, and that today there are some big animals that are from the group that can fly. If you use numbers to take how big they are out of the running, it seem like some of these foot falls could be from big animals part of the group that can fly.   References: Abrahams, Miengah, and Emese M. Bordy. "The oldest fossil bird-like footprints from the upper Triassic of southern Africa." Plos one 18.11 (2023): e0293021. Hong, Sung-Yoon, et al. "The discovery  of Wupus agilis in South Korea and a new quantitative analysis of  intermediate ichnospecies between non-avian theropods and birds." Cretaceous Research 155 (2024): 105785.

Discover how the perfectionist sunk cost fallacy could be holding you back and learn how to break free from its grip. From wearing clothes you hate, to staying in relationships or careers way past their expiration date, Sunk Cost fallacy is a lethal landmine for perfectionistic people. Find out if you're making decisions aligned with your values or loss aversion, sunk cost definition for perfectionists, tricks sunk cost effect plays on you, why its challenging to see your own sunk costs, IRL sunk cost fallacy examples and how perfectionists can stop falling prey to sunk cost suck-i-ness forever.Tired of waiting for “things to calm down” so you can FEEL better? Whether it's becoming much more DECISIVE in everything you do, the ability to fall asleep without obsessing over your to do list or PRESENCE with your family (no more catastrophizing) When you join Perfectionism Leveraged you get customized 1-1 coaching + the SKILLS you've never been taught that FREE you from sunk cost fallacy + lethal perfectionism landmines. Get your stress-free start today at https://courtneylovegavin.com/servicesPositive Perfectionist Practices for Removing Sunk Cost Fallacy:Identify Sunk Cost Fallacy: Recognize where you're holding onto investments, relationships, or decisions you would not re-choose for yourself today BC you've “already spent so much time, energy, money or effort”If You Want Your Future, Forget Your Past: Stop living in the prison of your past choices and exit to the playground of possibility. Dropping the black and white thinking that persevering = productiveMake intentional decisions that empower you for the rest of your life: Check your choices with your values and pivot away from unfulfilling situations or relationships.Practice Makes Permanent: To progress 100x faster, make the journey funner and strengthen your interoceptive awareness consider working with a perfectionism coachHighlights inside Episode 198 of Perfectionism Rewired:00:00-Perfectionists + Sunk Costs01:51-What is sunk cost fallacy03:26-Shedding the Weight of Sunk Costs04:56-Being Resourceful instead of limiting your resources05:36-Sunk Cost Effect in Unfulfilling Careers + Unhappy Relationships07:12-Why FEELS Smart To Continue Pouring Money, time, effort when you've already sunk09:18-Putting yourself in the victim drama triangle11:10-Sunk Cost With Example Baby Gucci Loafers12:03-Quick Correct Choices with Embodied Presence Interoceptive Connection13:32-when to persevere and when to pivot14:36-Prioritizing your values over sunk costs15:50-No longer a victim to chronic overachieving18:17-Proud of yourself regardless of how much you accomplishRich Resources Mentioned In This Sunk Cost Episode:How I Lost 50 pounds by Being The Worst (Leveraging Perfectionism video)Perfectionist's Guide to Uncovering Victim Mentality  (Part 1)Mamba Mentality vs Victim Mentality (Part 2)Are You Living In The Victim Triangle? (Perfectionism Rewired ep. 181)Starter Perfectionism Rewiring 1-1 Coaching  Pack (steal of a deal)HIGHLY CREDIBLE SOURCES ON SUNK COST REFERENCED IN THIS EPISODE:  Dijkstra, K. A., & Hong, Y. Y. (2019). The feeling of throwing good money after bad: The role of affective reaction in the sunk-cost fallacy. PloS one, 14(1), e0209900. https://doi.org/10.1371/journal.pone.0209900Jarmolowicz, D. P., Bickel, W. K., Sofis, M. J., Hatz, L. E., & Mueller, E. T. (2016). Sunk costs, psychological symptomology, and help seeking. SpringerPlus, 5(1), 1699. https://doi.org/10.1186/s40064-016-3402-zSchmitzer-Torbert N. (2020). Mindfulness and decision making: sunk costs or escalation of commitment?. Cognitive processing, 21(3), 391–402. https://doi.org/10.1007/s10339-020-00978-4Schulreich, S., Dandolo, L. C., & Schwabe, L. (2022). Sunk costs under stress: Acute stress reduces the impact of past expenses on risky decisions. Psychoneuroendocrinology, 137, 105632. https://doi.org/10.1016/j.psyneuen.2021.105632Tait, V., & Miller, H. L., Jr (2019). Loss Aversion as a Potential Factor in the Sunk-Cost Fallacy. International journal of psychological research, 12(2), 8–16. https://doi.org/10.21500/20112084.3951Zeng, J., Zhang, Q., Chen, C., Yu, R., & Gong, Q. (2013). An fMRI study on sunk cost effect. Brain research, 1519, 63–70. https://doi.org/10.1016/j.brainres.2013.05.001‌‌‌ Perfectionism Rewired Ethics + Transparency:Perfectionism Rewired podcast is brought to you by Perfectionist Solutions and is committed to neuroscience truth and accuracy through a perfectionism affirming lens.What does Perfectionist Affirming mean? Perfectionism affirming is an empowered view where perfectionistic tendencies are not seen as deficits to be “fixed” and nobody is a victim of perfectionism. Instead you are fully in charge of YOU, given tools for agency and perfectionism is leveraged to work for you. Part of neuorinclusivity movement that sees all humans as uniquely wired individuals who all experience the world differently.

Marcus and Will kick off the holiday season by reviewing a newly published predator-prey diet selection study, discussing fall diets for turkeys during poor oak masting years, and touching upon the American tradition of fall turkey hunting.    Resources Youngmann, et al. (2023). Assessing springtime vertebrate prey of sympatric mesopredators in the southeastern United States using metabarcoding analysis. Plos one, 18(10), e0293270. DrDisturbance IG Reel   Dr. Marcus Lashley (@DrDisturbance) (Academic Profile) Dr. Will Gulsby (@dr_will_gulsby) (Academic Profile) Turkeys for Tomorrow (@turkeysfortomorrow)  UF DEER Lab (@ufdeerlab) (YouTube)   Watch these podcasts on YouTube: Wild Turkey Science YouTube   Donate to wild turkey research: UF Turkey Donation Fund , Auburn Turkey Donation Fund  This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.  Help us help turkeys by rating this podcast and sharing it with your friends and family.    Music by Artlist.io Produced & edited by Charlotte Nowak   

Marcus and Will kick off the holiday season by reviewing a newly published predator-prey diet selection study, discussing fall diets for turkeys during poor oak masting years, and touching upon the American tradition of fall turkey hunting.    Resources Youngmann, et al. (2023). Assessing springtime vertebrate prey of sympatric mesopredators in the southeastern United States using metabarcoding analysis. Plos one, 18(10), e0293270. DrDisturbance IG Reel   Dr. Marcus Lashley (@DrDisturbance) (Academic Profile) Dr. Will Gulsby (@dr_will_gulsby) (Academic Profile) Turkeys for Tomorrow (@turkeysfortomorrow)  UF DEER Lab (@ufdeerlab) (YouTube)   Watch these podcasts on YouTube: Wild Turkey Science YouTube   Donate to wild turkey research: UF Turkey Donation Fund , Auburn Turkey Donation Fund  This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.  Help us help turkeys by rating this podcast and sharing it with your friends and family.    Music by Artlist.io Produced & edited by Charlotte Nowak   

Do you feel addicted to sugar? Is sugar really as addictive as drugs? How do I stop binging on sugar? We cover it all in this episode. Uncover the facts on sugar addiction with Abbey as she summarizes the research and applies it to everyday life. Follow Abbey on Instagram and Tiktok: @fork.diet.culture Learn more about Abbey or find support here: https://www.abbeyroberts-rd.com Citations: Ahmed SH, Guillem K, Vandaele Y. Sugar addiction: pushing the drug-sugar analogy to the limit. Curr Opin Clin Nutr Metab Care. 2013;16(4):434-439. doi:10.1097/MCO.0b013e328361c8b8 Mark GP, Blander DS, Hoebel BG. A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion. Brain Res. 1991;551:308–10. Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007, August 1). Intense sweetness surpasses cocaine reward. PloS one. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931610/ Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134(3):737-744. doi:10.1016/j.neuroscience.2005.04.043 Greenberg, D., & St Peter, J. V. (2021). Sugars and Sweet Taste: Addictive or Rewarding?. International journal of environmental research and public health, 18(18), 9791. https://doi.org/10.3390/ijerph18189791 Lenoir M, Serre F, Cantin L, Ahmed SH. Intense sweetness surpasses cocaine reward. PLoS One. 2007;2(8):e698. Published 2007 Aug 1. doi:10.1371/journal.pone.0000698

Today's episode doesn't need a whole lot of explanation: I had asparagus one day and couldn't help but wonder about a peculiar scent. If you eat asparagus, you know exactly what I'm talking about. So I dove into the research and learned way more about asparagus than I ever thought I would

Today we will be diving deep into the realms of our own behavior and how it shapes the quality of our lives, whether facing the shadows of depression or merely seeking a brighter outlook and a more fulfilling existence. I kickstart our discussion with a brief overview of depression and the notorious depression cycle, an abyss many find hard to escape. However, our focus soon shifts to a ray of hope—the transformative approach of Behavioural Activation (BA). As we dissect Behavioural Activation, it becomes apparent that its principles are not only for those battling depression but provide a treasure trove of insights for anyone yearning for a richer, more engaged life. BA encourages a proactive engagement with valued and mood-enhancing activities, propelling us away from the clutches of negativity and into a space of positive action. The conversation gets more captivating as we traverse into the heart of Behavioural Science, spotlighting Operant Conditioning. By delving into the mechanisms of reinforcement and punishment, we unfold the potential to cultivate healthier, more adaptive behaviors, setting the stage for a harmonious interplay between our actions and emotions. (Some might find it a little dry, but it's necessary to understand to get the most out of BA). To ensure that this dialogue translates into real-world, positive change, I introduce the concept of Behavioural Activation Homework. This actionable strategy provides a platform for you to integrate the discussed principles into your daily routine, thus fostering a proactive stance towards life's challenges and joys alike. As with every episode, my aim is to arm you with actionable takeaways that can be applied TODAY, embarking on a journey of self-discovery and positive transformation. So, whether you're wrestling with depressive symptoms or simply eager to enrich your life's narrative, the essence of Behavioural Activation paves the way for a profound personal revolution. Together, with every episode, we're not only decoding the science of behavior but also nurturing a proactive spirit to thrive amidst life's kaleidoscope of experiences. Remember, the potential for change is but a thought away, and through the insights shared on this podcast, we're forging a path toward a more vibrant and fulfilling tomorrow. HOMEWORK Timestamps (so when you're coming back to it you don't have to scroll around trying to find it every time you come back to it). 1. Activities Schedule: 32:50 2. Values Inventory: 35.53 I don't have links to my own values inventory or activity schedule plan atm - but a quick google and I know you'll find it. References: Honestly, I swear the universe just wants me to find these open access papers for you. Ekers, D., Webster, L., Van Straten, A., Cuijpers, P., Richards, D., & Gilbody, S. (2014). Behavioural activation for depression; an update of meta-analysis of effectiveness and sub group analysis. PloS one, 9(6), e100100. https://doi.org/10.1371/journal.pone.0100100 --- Send in a voice message: https://podcasters.spotify.com/pod/show/thevertuepodcast/message

Merriam-Webster's Word of the Day for July 25, 2023 is: null • NULL • adjective Null is a technical term. In law it is commonly used in the phrase "null and void" to describe something that has no legal or binding force. Null also has several zero-related meanings, including "amounting to nothing," "having no value," "having no elements," "having zero as a limit," and "of, being, or relating to zero." // After careful review, the contract was declared null and void. // A null vote is a rejection of all the ballot's candidates. See the entry > Examples: "While negative and null results can often be overlooked—by authors and publishers alike—their publication is equally as important as positive outcomes and can help fill in critical gaps in the scientific record." — PLOS.org, 6 Apr. 2020 Did you know? Let's be honest: null is kind of a nothing word. That's not a judgment—it was literally borrowed into English from the Anglo-French word nul, meaning "not any." That word, in turn, traces to the Latin word nullus, from ne-, meaning "not," and ullus, meaning "any." Null often pops up in legal and scientific contexts; it was originally used in Scottish law and still carries the meaning "having no legal or binding force," especially in the phrase "null and void." In mathematics, it is sometimes used to mean "containing nothing"; for example, the set of all whole numbers that are divisible by zero is the "null set" (that is, there are no numbers that fit that description). Null is occasionally seen in non-technical contexts with the meaning "lacking meaning or value," as in "if no one reads it, the book's content is null."