Podcasts about Neuroinflammation

Send us a textGood morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're diving into a landscape rich with scientific innovation, regulatory scrutiny, and strategic business decisions shaping the future of healthcare.Let's begin with Novartis, which has achieved a significant milestone by securing FDA approval for Itvisma. This is an intrathecal formulation of its gene therapy Zolgensma, designed to treat older patients with spinal muscular atrophy (SMA). Priced at $2.59 million, this approval is a critical advancement in gene therapy for SMA, broadening the treatment horizon for a wider patient demographic. Gene therapies are increasingly crucial in addressing rare genetic disorders, offering transformative potential in patient care. Novartis's SMA market expansion post-FDA approval of Itvisma not only enhances its SMA portfolio but also signifies growing acceptance towards gene therapies as viable treatment options for genetic disorders. Meanwhile, Novartis is strategically restructuring, planning to cut 550 jobs at a Swiss plant by 2027 while expanding its workforce in North Carolina. This move reflects broader industry trends toward optimizing global operations and investing in regions with strategic manufacturing capabilities.In the sphere of regulatory scrutiny, lawmakers are questioning the FDA's National Priority Voucher Program amid concerns about corruption and expedited reviews. This situation highlights ongoing challenges within regulatory frameworks to balance innovation speed with rigorous safety assessments. An investigation into the FDA's new priority review voucher program has been initiated due to concerns over corruption and expedited review processes potentially compromising drug safety. This inquiry could influence future regulatory frameworks and underscores balancing accelerated drug approvals with rigorous safety standards. Richard Pazdur expressed concerns about expedited drug approval programs' safety and legality as he takes on his new role as director of the FDA's Center for Drug Evaluation and Research. These initiatives aim to accelerate drug reviews but spark debate over patient safety implications—underscoring an ongoing tension between innovation speed and regulatory diligence.Turning to Novo Nordisk, their expansion of the Amycretin program demonstrates a commitment to tackling chronic conditions like diabetes. Following promising Phase 2 data showcasing dual agonist capabilities, Novo Nordisk is advancing pivotal trials focused on obesity. This strategic pivot aligns with market needs and scientific discoveries that could significantly enhance diabetes management options. Further emphasizing Novo Nordisk's commitment to diabetes management, their expansion of the amycretin program after promising Phase 2 results demonstrates the efficacy of a dual agonist originally focused on obesity. This underscores a trend toward multifunctional biologics addressing metabolic disorders by targeting multiple pathways—indicative of broader industry shifts towards integrated therapeutic approaches. Novo Nordisk's recent mid-stage clinical trial results for Amycretin—a weight loss treatment—are noteworthy as they demonstrated sustained efficacy over 36 weeks in type 2 diabetes patients without a plateau in weight loss. Analysts highlight its potential as a superior therapeutic option in the burgeoning weight loss market due to its durable solution for weight management.On a contrasting note, SK Life Science encounters regulatory hurdles as the FDA scrutinizes advertising practices related to its antiseizure medication Xcopri. This scenario underscores the complex interplay between marketing strategies and regulatory compliance within the pharmaceuticSupport the show

“The spike protein from COVID is a true age accelerant,” explains Robin Rose, D.O. Rose, a double board-certified gastroenterologist, internal medicine specialist, and CEO of Terrain Health, joins us today to explain how lingering viral proteins from COVID can continue to affect the gut, brain, and immune system—and what we can do to identify and address their lasting impact. - What is Long COVID? (~2:00) - How to know if you have Long COVID (~3:45) - Which biomarkers can signal Long COVID (~7:05) - Asymptomatic presentations (~13:00) - The connection to neurodegenerative diseases (~18:50) - Why this is important for everyone (~21:50) - The impact of COVID on the body (~23:55) - How to detox from Long COVID (~28:15) - The impact on the gut (~38:00) - Conversations to have with your practitioner (39:45~) - The biomarkers to test (~41:50) - Final thoughts (~48:05)    Referenced in the episode:  - Follow Rose on Instagram (dr.robinrose) - Check out her clinic, Terrain Health (https://terrainhealth.org/)  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's. The episode delves into lifestyle interventions such as ketogenic diets, fasting, and nutritional impacts to manage and potentially reverse the detrimental shift in microglial behavior.

Synopsis: In a conversation rich with strategic insight, Coya Therapeutics CEO Arun Swaminathan unpacks the intersections of scientific innovation, business development discipline, and capital-efficient execution that define today's most resilient biotechs. With a 25-year foundation spanning R&D, clinical pharmacology, marketing, and BD, Arun offers investors a rare systems-level lens on how neurodegenerative programs progress from hypothesis to value inflection. Through his dialogue with host Alok Tayi, he breaks down Coya's differentiated Treg-modulating platform and the data emerging across ALS, FTD, and Alzheimer's. He explains why Coya's dual-mechanism approach—restoring regulatory T-cell function while reshaping the neuroinflammatory environment—is uniquely poised to change patient trajectories. Arun also delves into the structural logic behind Coya's partnership with Dr. Reddy's, demonstrating how complementary strengths in manufacturing, commercialization, and regulatory strategy can dramatically shift both timelines and capital needs. For investors tracking macro trends, he contextualizes shifting interest rates, pipeline gaps, and rising M&A momentum—and why 2026 may mark the beginning of a healthier biotech cycle. A must-listen for anyone evaluating platform durability, risk mitigation strategies, and next-generation neurodegenerative therapeutics. Biography: Arun Swaminathan, Ph.D., has over 20 years of hands-on healthcare business executive experience with an emphasis on corporate and business development, strategy, and finance. He possesses a demonstrated history of prospecting, evaluating, structuring, and closing company validating transactions that augment both organizational and shareholder value. Prior to joining Coya, Arun served as Chief Business Officer (CBO) for Actinium Pharmaceuticals (NYSE: ATNM) where he was responsible for all business development. Within 1 year of joining Actinium, he successfully moved forward negotiations to closure and executed a $452M deal with $35M upfront. Prior to Actinium, he was the CBO at Alteogen (196170.KQ) where he spearheaded over $6B in deals, including deals with two of the top 10 global pharma companies and a $1B+ deal within the first year of assuming the role of CBO. Prior to this, he co-founded and served as CEO of Lynkogen Inc, a pre-clinical stage biotech. Arun began his career in clinical development and commercial roles of increasing responsibility at BristolMyers Squibb and Covance. He obtained his Ph.D. in pharmaceutical sciences from the University of Pittsburgh.

ChatGPT said:What if the real fallout from a head knock is not the moment of impact, but the silent systemic storm that unfolds in the weeks, months and even years that follow?In this powerful episode, clinical naturopath Louise Cork reframes concussion as a whole-body injury that is widely underreported, frequently misunderstood, and too often treated as an isolated knock to the head. Drawing on years of clinical experience, Louise explains why symptoms can appear long after the incident, how intestinal permeability and a disrupted microbiome can amplify neuroinflammation, and why a gut-first approach often becomes the missing link in recovery.We explore the systemic cascade that follows impact: increased intestinal permeability, a leaky blood-brain barrier, microglial priming, altered HPA axis signalling and hormone shifts such as low testosterone in men. Louise shows how these shifts can present as headaches, fatigue, anxiety, poor stress tolerance and slow injury recovery. A compelling motocross case study highlights how mapping a patient's clinical timeline across body systems can reveal the turning points many people overlook.We then move into practical strategies. Louise shares evidence-informed tools to repair the terrain and calm an oversensitised brain, including stool-guided treatment plans, endotoxin control with SBI and S. boulardii, targeted probiotics, and nutraceuticals such as saffron for mood and NFkB regulation, PEA for endocannabinoid balance and pain, omega 3s for inflammatory resolution, and thoughtful curcumin use that considers COX LOX balance without overloading the liver. We also explore sleep as a primary therapy, the role of the glymphatic system in clearing neuroinflammation, and how nutrients like L-theanine can deepen rest without immediately reaching for melatonin.Prevention is a major focus. Whether you are working with athletes, military personnel, domestic violence survivors or high-risk workers, Louise outlines how optimising gut health, sleep, recovery rituals and nutritional foundations can reduce the fallout when impacts occur.If you have had a knock, care for someone who has, or support patients navigating persistent symptoms, this episode offers a clear and actionable framework: assess deeply, repair the gut, calm the brain, support sleep and tailor the plan to the individual.If this episode supports you or someone you love, follow the show, share it with a teammate or colleague, and leave a review so more people can access these tools.Connect with Louise:  www.theconcussionnaturopath.comShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

“VO2 max is the best predictor of lifespan,” says Peter Attia, M.D. Peter Attia, M.D., physician, founder of Early Medical, and expert in the applied science of longevity, joins us today to break down the key levers for extending both lifespan and healthspan—from how to train for a higher VO2 max to the biomarkers that truly predict long-term health. - The most powerful habit for longevity (~6:15) - VO2 max (~8:55) - How to increase your VO2 max (~10:08) - Heart rate vs. perceived exertion (~12:35) - Attia's strength training routine (~15:20) - 2 exercises Attia stopped doing (17:00) - Diminishing returns in terms of exercise (~19:55) - His take on wearables (~21:25) - Cardiovascular disease markers (~23:38) - Lowering ApoB (~25:35) - Pharmaceutical interventions for LDL & ApoB (~27:50) - Neuroinflammation markers (~37:25) - Perspectives on statins (~40:45) - The role of nutrition (~42:50) - Potential benefits of GLP-1s (~45:00) - Peptides (~47:50) - The power of exercise (~51:00) Referenced in the episode:  - Follow Attia on Instagram (@peterattiamd) - Listen to his podcast, The Peter Attia Drive  - Check out his website (https://peterattiamd.com/)  - Pick up his book, Outlive: The Science of Art & Longevity  - Take his class on MasterClass (https://www.masterclass.com/series/science-for-a-longer-better-life) - Watch the trailer for his class on MasterClass (youtube.com/watch?v=f_Mz095swls&feature=youtu.be)   We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the key to a calmer brain wasn't meditation or medication — but microbes?In this episode of Migraine Heroes Podcast, host Diane Ducarme reveals how fermented foods and fiber may be your brain's most natural mood stabilizers. Drawing on neuroscience and Eastern medicine, she explains how your gut-brain axis uses bacteria, fiber, and fermentation to create calm, focus, and resilience against migraines.You'll discover:

Sartori, Christina www.deutschlandfunk.de, Sprechstunde

Nicotine isn't just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you'll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll discover how nicotine affects neurotransmitters, why it may help with ADHD and focus, and how it compares to other cognitive enhancers like caffeine, nootropics, and even smart drugs. Dave explores how nicotine can be used to hack metabolism, enhance sleep optimization, and support fasting or ketosis protocols—if used properly. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll Learn: • How nicotine affects mitochondria, neurotransmitters, and dopamine signaling • Why nicotine may boost neuroplasticity, memory, and attention span • How low-dose nicotine compares to caffeine, modafinil, and other nootropics • The safest delivery forms (and the ones to avoid) • Whether nicotine supports or hinders longevity and cognitive resilience • How it can be stacked with supplements, fasting, or ketosis • What functional medicine says about chronic use, addiction, and withdrawal This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Nicotine microdosing, Nicotinic acetylcholine receptors, Dopamine and motivation, Cognitive enhancement, Alzheimer's prevention, Neuroinflammation, Mitochondrial function, TNF-alpha reduction, Vagus nerve activation, Longevity biohacking, Nicotine vs smoking, Nootropics, Attention and vigilance, Ketosis and metabolism, Functional medicine, Nicotine patches and gum, Addiction and tolerance, Receptor desensitization, Withdrawal protocols, Deep work performance Thank you to our sponsors! -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 1:27 — History & Background of Nicotine 4:34 — How Nicotine Works 15:12 — Benefits & Research 16:43 — Risks & Who Should Avoid It 21:39 — Delivery Methods & Dosing 26:30 — Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Kendal Stewart has dedicated his life's work to uncovering root causes and tailoring individualized solutions through genetic testing, functional medicine, and integrative care. His approach emphasizes prevention as much as treatment, using lifestyle, nutrition, and nervous system support as daily fuel for better brain function. A nationally recognized expert in neuroimmune disorders— including genetic abnormalities, chronic pain, ADD/ADHD and autism spectrum conditions, he provides practical tools to regulate stress, stabilize energy, boost mental clarity, and gain overall wellness. Key Topics: - Definition of neuroimmune syndrome and how it shows interconnectedness in the brain and body - The connection between the nervous system and inflammation and insulin resistance - Auto antibodies to look at with neuroinflammation to understand the cause - How genetic SNPs play a role in neuroimmune dysfunction - The impact of GI inflammation - Individualizing the approach to healing For more info, head to drkendalstewart.com. Listen to his podcast: Coffee with Dr. Stewart Join Erin's monthly mailing list to get health tips and fresh meal plans and recipes every month: https://mailchi.mp/adde1b3a4af3/monthlysparksignup Order Erin's new book, Live Beyond Your Label, at erinbkerry.com/upcomingbook/

Send us a textCould the key to brain health be found in your DNA—and on your plate?Welcome to Season 2 of The Neurological Disorder Podcast! This week's episode is with Dr. Kendal Stewart, a certified head and neck surgeon and otolaryngologist. In addition to founding several medical companies and even receiving a U.S patent for one of his technologies, Dr. Stewart treats individuals with neuro-immune syndromes through innovative techniques and by analyzing the root of issues at the cellular and molecular level.In this conversation, we explore connections between neuroinflammation, Alzheimer's, and POTS, and dive into the role of nutrigenomics in neurological disorders. Moreover, we explore nutrition strategies for reducing neuroinflammation, and Dr. Stewart simplifies complex biomolecular topics that enrich this conversation. So whether you're a healthcare professional, a student, or just curious about how diet and genetics impact your nervous system, you'll definitely walk away learning something new.Don't forget to rate and subscribe to The Neurological Disorder Podcast on Spotify, Apple Podcasts, or wherever you listen to your podcasts. Fill out this form ( https://forms.gle/V8ZrX8iwQZnk3xVF9) if you have questions, guest suggestions, or topics you would love to hear about! Feel free to contact me via:Email: neurologicaldisorderpodcast@gmail.comInstagram: @neurologicaldisorderpodcastWatch Dr. Stewart's podcast:Coffee With Dr. Stewart: https://podcasts.apple.com/us/podcast/coffee-with-dr-stewart/id1183857037

In today's episode, we're diving into some brand new, cutting-edge research that turns the spotlight on microglia—the tiny, yet mighty immune cells in your spinal cord. Dr. Jeff explores a recent review published in Frontiers in Immunology that unpacks how microglia play a pivotal role in neuroinflammation, plasticity, and recovery after spinal cord injury.Episode Notes: Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cordLeander Tables- Save $1,000 on the Series 950 Table using the code EBC2025 — their most advanced flexion-distraction tablePatient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!

References EMBO J . 2023 Feb 1;42(3):e111998. Experimental & Molecular Medicine 2024. v.56,:1250–1262Genet Mol Biol. 2016 Aug 4;39(3):312–328. Ageing Res Rev. 2016 Mar 15;33:105–11PLoS Genet. 2010 Dec 2;6(12):e1001228Hendrix, J. 1967. Little Wing Derek and the Dominoes-Layla lp.https://music.youtube.com/watch?v=EOW9aixXnq4&si=oJfShR5rvxa7iJB1Dylan, B. 1967. All Along the Watchtower Jimi Hendrix Experiencehttps://music.youtube.com/watch?v=TLV4_xaYynY&si=55zsnL--bUcWYZSzZappa, F. 1975. Black Napkinshttps://music.youtube.com/watch?v=RfHT-T6R6WY&si=-hOcciVfN1pqky5_McTell, BW. 1928.Statesboro Blues. .Allman Brothershttps://music.youtube.com/watch?v=dWy3Q30Cn2A&si=L9DCovynACHVtb2-Pachelbel. , J. 1680 Canon in D.https://music.youtube.com/watch?v=lgh68Swuak0&si=DMo20XaV9hvhI8o3

Nurses Out Loud with Melissa Schreibfeder, BSN, RN, BC-FMP – Neuroinflammation is often the missing link in chronic childhood conditions like PANS/PANDAS, ADHD, and more. In this episode, I sit down with Danielle Friend, a functional wellness nurse, to uncover how immune issues, toxins, and nutrient gaps disrupt children's lives—and how holistic strategies offer real hope, healing, and answers for families searching for deeper...

Nurses Out Loud with Melissa Schreibfeder, BSN, RN, BC-FMP – Neuroinflammation is often the missing link in chronic childhood conditions like PANS/PANDAS, ADHD, and more. In this episode, I sit down with Danielle Friend, a functional wellness nurse, to uncover how immune issues, toxins, and nutrient gaps disrupt children's lives—and how holistic strategies offer real hope, healing, and answers for families searching for deeper...

Dr. Hoffman continues his conversation with Dr. Chris Rhodes, a clinical fasting, longevity, and biomimetics researcher at UC Davis.

Dr. Chris Rhodes, a clinical fasting, longevity, and biomimetics researcher at UC Davis, discusses various fasting methods including time-restricted feeding, intermittent fasting, and prolonged fasting. He highlights the biochemical processes involved, such as autophagy and metabolic adaptation, and underscores the potential health benefits of fasting, which include improved metabolic markers and extended lifespan as evidenced in animal models. Dr. Rhodes also introduces Mimio, a supplement developed from his research designed to mimic the benefits of fasting without actual food deprivation, detailing its composition and the promising clinical results. The discussion weaves through scientific insights, personal experiences, and practical applications of fasting and fasting-mimicking agents.

Andreas Schlecht beleuchtet die zellulären Risiken von Lipid-Nanopartikeln und zeigt, wie regenerative Peptide wie KPV potenziell bei Long Covid, Neuroinflammation und hormonellen Dysfunktionen helfen könnten – trotz regulatorischer Hürden.Hilfreiche Komplexe: Long C: https://www.sunday.de/long-c-komplexe/ (Code: TAN34909) Acetyl L-Carnitin: https://www.sunday.de/acetyl-l-carnitin-kapseln.html (Gutschein: TAN34909) Molecusan: https://molecusan.com/products/liquid-spectrum (Code: vegan10)

Dr. Tony Ebel reveals the deeper truth about neuroinflammation in children with autism, ADHD, epilepsy, and other chronic health challenges. While diet changes, detoxes, and supplements target inflammation at the surface level, the real on-off switch to neuroinflammation lies much deeper—in the vagus nerve. Dr. Ebel explains how vagus nerve dysfunction creates a traffic jam in the body's anti-inflammatory pathways, keeping children trapped in chronic sympathetic fight-or-flight mode. He shares the powerful story of Ethan, a child with severe autism who experienced dramatic healing once his vagus nerve was properly activated through Neurologically Focused Chiropractic Care. This episode provides parents with a clear understanding of why their child may still be experiencing inflammation despite trying every diet and supplement, and offers hope by addressing the underlying neurological cause.Key Topics & Timestamps([00:02:00]) - The Inflammation Truth - Why "inflammation is the root of all disease" is accurate but incomplete, and how it affects every body system([00:07:00]) - Enter the Vagus Nerve - Introduction to the vagus nerve as the primary controller of the body's anti-inflammatory response([00:10:00]) - Why Traditional Methods Fail - Explaining why deep breathing and calming techniques don't work when the vagus nerve is shut down([00:16:00]) - The Traffic Jam Analogy - How subluxation creates a "traffic jam" preventing proper brain-gut-immune communication([00:19:00]) - Ethan's Story - Case study of a child with severe autism who transformed through vagus nerve activation([00:24:00]) - The Chiropractic Solution - Why neurologically focused chiropractic care is the most powerful tool for addressing neuroinflammation([00:27:00]) - Sequential Healing Approach - The importance of addressing vagus nerve dysfunction first before layering other interventions-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!

In this powerful episode of Converge Autism Radio, Dr. Stephanie Holmes speaks with Dr. Eric Weiss—surgeon, stem cell pioneer, and father to a son on the spectrum. Driven by personal experience, Dr. Weiss shares the emotional and scientific journey that led him to explore stem cell therapy for autism. From groundbreaking brain inflammation research to real-world results with his son, this conversation unpacks the potential of regenerative medicine to improve quality of life for autistic individuals. Listeners will learn about:The link between brain inflammation and autism symptomsHow umbilical cord stem cells are being used safely and effectivelyWhy stem cell therapy may open new doors for older autistic individualsThe personal breakthroughs that changed Dr. Weiss's career pathHow diet, gut health, and stem cells can support a holistic healing journeyWhether you're a parent, professional, or curious soul, this episode brings fresh insight and real hope.Dr. Eric Weiss is a board‑certified plastic surgeon and former U.S. Navy Commander who pivoted his career to regenerative medicine after his son Marston was diagnosed with autism and showed remarkable gains following umbilical cord stem cell therapy. Now serving as Medical Director of the Autism Program at Miami Stem Cell and founder of North Florida Stem Cells, he has treated over 400 children with data-driven protocols—reporting developmental improvements in about 65–70% of them—using MSCs, exosomes, MRI/EEG monitoring, and rigorous safety standards. He's also co‑author of Educating Marston and a frequent podcast guest, sharing both personal experience and emerging science in autism care.https://northfloridastemcells.com/

Dr. Eric Weiss is a leader in advanced regenerative medicine and the co-author of Educating Marston. Founder of the North Florida Stem Cells Clinic, Dr. Weiss provides stem cell replacement therapy to treat various conditions such as Osteoarthritis (OA), Rheumatoid Arthritis (RA), and Traumatic Brain Injury (TBI), with a special focus on the treatment of Autism. In this episode, Dr. Eric Weiss, a plastic surgeon and stem cell therapy expert, discussed his journey into stem cell research after his son was diagnosed with autism, explaining the connection between brain inflammation and autism, and the potential of stem cell therapy in treating various conditions. Key Topics: - The connection between inflammation and autism - The success of stem cell therapy for autism - Other benefits of stem cell treatment - The gut-brain connection and its role in inflammatory disorders - Umbilical cord stem cell uses - Behavioral changes in kids with stem cell treatments - Why stem cell research has been controversial and why it shouldn't be Learn more about Dr. Weiss' work at ericweissmd.com. Grab his book at educatingmarston.com Join Erin's monthly mailing list to get health tips and fresh meal plans and recipes every month: https://mailchi.mp/adde1b3a4af3/monthlysparksignup Preorder Erin's new book, Live Beyond Your Label, at erinbkerry.com/upcomingbook/

Is your child struggling—and you're not getting answers from “normal” tests? Hit play. This could change everything. In Part 2 of my powerful conversation with Dr. Theoharis Theoharides, we explore how neuroinflammation, mast cell activation, and overlooked biological factors can affect autistic children. We dive into my son Gavin's journey, how traditional testing failed us, and what we discovered when we looked deeper. If you've ever felt dismissed or unsure where to turn next, this episode will give you new hope and direction. Why this matters: Too often, symptoms like gut issues, eczema, or extreme food sensitivity get brushed off. Dr. Theo shares what many pediatricians miss—and how identifying and treating the right things can dramatically improve quality of life for neurodivergent kids. What We Cover: What neuroinflammation means for autistic children How mast cells can impact behavior, speech, and health Why standard labs often miss important clues The difference between food allergies and food sensitivities What to test for—and how those tests can uncover treatable issues Gavin's personal health journey and the lessons we've learned How to support your child without trying to change who they are Why we need real research, not empty promises Sponsor: Mama Bird Mama Bird Kids Multi+ is brain-focused nutrition for neurodivergent kids. Designed by a neurologist and autism mom, these supplements support focus, mood, and learning—without sugar alcohols or artificial dyes. Available in liquid (ages 1+) and gummy (ages 4+). Get 20% off your first order at lovemamabird.com/theautismdad Mightier helps kids learn emotional regulation through fun, biofeedback-powered games. Developed by clinicians at Boston Children's Hospital and Harvard Medical School, Mightier is a screen-based program that teaches kids to stay calm under pressure—while they play. USe the code "theautismdad20" to save 10% Learn more by visiting https://theautismdad.com/mightier Enjoying the podcast? Please follow or subscribe so you never miss an episode. For more support, visit theautismdad.com, where you'll find expert interviews, honest parenting stories, and trusted resources to help your family thrive. Guest Bio: Dr. Theoharis Theoharides Dr. Theo is a renowned physician-scientist and expert on mast cells, allergies, and neuroinflammation. With decades of research and hundreds of publications, he helps families uncover treatable biological conditions often missed in traditional autism care. Learn more at drtheo.com and algonot.com. Host Bio: Rob Gorski Rob Gorski is the father of three autistic children and the creator of The Autism Dad blog and podcast. He's been sharing his family's 25-year autism journey to help other parents feel seen, supported, and empowered. Rob's work has been featured by CNN, ABC News, BBC, and more.

Is it ADHD… or something else entirely? This episode dives into one of the most debated topics in parenting and child psychology. Dr Justin Coulson answers a heartfelt question from a concerned parent: Should I pursue a formal ADHD diagnosis for my child — or are there better first steps to take? If you're feeling overwhelmed by symptoms, advice, and conflicting opinions, this conversation will help you slow down, zoom out, and see your child through a compassionate, research-informed lens. KEY POINTS: ADHD diagnosis rates are rising — but is it always the right label? Some children may be diagnosed for what is actually normal developmental variation or environmental mismatch. ADHD-like symptoms may be a child’s way of trying to meet three unmet psychological needs: Connection (relatedness) Capability (competence) Control (autonomy) Neuroinflammation is an emerging and overlooked factor in ADHD symptoms. Developmental readiness matters — an 8-year-old’s brain is still undergoing major executive function development. Rather than trying to eliminate stress, parents can help children build capacity to handle challenge (a growth mindset). Medication might help some, but it’s not the first (or only) answer. Diagnosis should be thoughtful, multi-faceted, and whole-child focused. QUOTE OF THE EPISODE: "Difference doesn't mean disorder. Development is not a race." – Dr Justin Coulson RESOURCES MENTIONED: The Parenting Revolution by Dr Justin Coulson Happy Families – for more articles, podcast episodes, and parenting resources Self-Determination Theory & Growth Mindset research Parenting ADHD [The Course] ACTION STEPS FOR PARENTS: Delay formal diagnosis (unless impairment is severe) and give time for development. Audit the environment for connection, competence, and autonomy — is it need-thwarting or need-supportive? Support physical health: Prioritise sleep, unprocessed foods, and movement. Explore reducing neuroinflammation through lifestyle. Teach a growth mindset: Use the word “yet”, encourage effort, and model learning through challenges. Reframe behaviours: Daydreaming may signal creativity, not dysfunction. Risk-taking may show courage and capability-seeking. Task resistance may be about autonomy, not defiance. If pursuing assessment, choose a clinician who understands development, context, and the whole child — not just a checklist. See omnystudio.com/listener for privacy information.

Could neuroinflammation be driving your child's symptoms? This episode will change how you think about autism and health. In this two-part series of The Autism Dad Podcast, I sit down with Dr. Theoharis Theoharides, one of the world's leading experts in neuroimmune medicine and mast cell research. We dig deep into how inflammation in the brain—driven by overactive mast cells—can contribute to the struggles many autistic and neurodivergent kids face, including sensory issues, eczema, gut problems, chronic sinus issues, and even regression. Dr. Theo doesn't just talk theory—he shares actionable steps and science-backed insights that have the potential to improve quality of life for families like ours. I even share some personal stories about my sons, and how this research explains things we've experienced for years. Whether your child is dealing with eczema, unexplained aggression, or GI issues, this episode may offer a new lens on what's going on under the surface—and what you can do about it. In this episode, we discuss: What mast cells are and how they can impact the brain How neuroinflammation may be linked to autism, ADHD, and chronic conditions The surprising connection between eczema and autism Why symptoms like gut issues and behavior changes are often misunderstood The role of vitamin D, folinic acid, and glutathione in autism support How stress can trigger mast cell activation and impact behavior What testing and natural interventions parents can explore How to think critically about supplements and avoid misleading claims This episode is sponsored by Safe Place Bedding Safe Place Bedding provides medically necessary, insurance-covered safety beds that help neurodivergent children sleep safely and securely—at home or while traveling. They've just launched the Safe Place 300, a permanent safety bed option with integrated monitoring. Visit https://safeplacebedding.com/theautismdad to learn more. If you found this episode helpful, please subscribe on Apple Podcasts, Spotify, or your favorite podcast app. You can also visit listen.theautismdad.com for more episodes, resources, and to leave feedback.

What if the root cause of anxiety, memory loss, or chronic fatigue after a brain injury isn't psychological, but hormonal? Will and Jon sit down with Dr. Mark Gordon, MD a trailblazer in neuroendocrinology, to uncover how traumatic brain injury (TBI) and chronic inflammation disrupt hormonal balance, often mimicking or masking conditions like PTSD. Dr. Gordon explains the science behind hormone therapy, the overlooked role of gut health, and why a 28-point biomarker panel could be the key to reclaiming brain function, especially for veterans.Find out more about Dr. Mark Gordon here - https://tbihelpnow.org/ or here: https://millenniumhealthstore.com/Try NEURISH - Personalized nutrition for your mental health. Get 15% off with Promo Code MTM. Visit https://tinyurl.com/57e68ett to learn more about this incredible daily supplement.Feeling stuck? If you need help getting out of your rut, Will can help. Head to willnotfear.comto learn more about his coaching to get you off the hamster wheel and into better decision-making.More from MTM at: https://mentalkingmindfulness.com/ Timestamps: 00:00 - Introduction02:47 - Neuroendocrinology's Role in Brain and Mood09:16 - CTE and Hormonal Disruption Explained12:03 - Hormonal Feedback Loops and Brain Function13:20 - Hormones, Inflammation, and Brain Health17:00 - Neuroinflammation and Cognitive Impact20:46 - Head Trauma and Long-Term Brain Decline26:29 - Inflammation's Lasting Effects on Healing28:50 - Subconcussive Hits, Gut Health, and the Brain33:31 - Boosting Brain Resilience: Military Lessons37:09 - Blast Exposure and Neurological Damage41:32 - Rethinking TBI and PTSD Treatment Options47:17 - Veteran Brain Health: Science Meets Policy50:18 - Ibogaine Therapy: Success in Alternative Care52:18 - Revisiting Testosterone's Role in Vitality55:28 - NSAIDs, Testosterone, and Better Alternatives58:58 - Nutrition, Selenium, and Hormone Support01:01:42 - NSAIDs, Pregnancy, and Endocrine Disruption01:07:35 - Libido Boosting with Testosterone and PT-14101:11:30 - New Approaches to Testosterone Therapy01:14:18 - Detox and Hormone Optimization01:15:57 - Clomiphene vs. Injectables: What Works?01:17:01 - TRT: Dosing Strategies and Side Effects01:19:02 - Balancing Testosterone and Estradiol01:22:42 - Why Hormone Balance Matters01:28:26 - Biomarker Testing for Brain Injury RecoveryHosted by Ausha. See ausha.co/privacy-policy for more information.

In this packed solosode of The Red Light Report, Dr. Mike Belkowski returns from the Biohacking Conference in Austin and dives into a rapid-fire review of five compelling new research articles — all centered around mitochondrial health, inflammation, and longevity. Topics covered: • Limonin as a natural anti-inflammatory agent for psoriatic skin via mTORC1 and ROS modulation • The role of mitochondrial oxidative stress in neuroinflammation and age-related diseases • How mitochondrial targeting may offer new treatments for allergic asthma • Photobiomodulation's influence on gut microbiota and its potential to reduce neuroinflammation • The power of C60 fullerenes to enhance muscle recovery, reduce fibrosis, and improve mitochondrial resilience Dr. Mike also shares insight into the new BioBlue Fountain of Youth supplement, highlights the ReVamp red light cupping system, and explains how mitochondrial support may be the next frontier in athletic performance and recovery. Whether you're managing chronic inflammation, recovering from injury, optimizing gut health, or pursuing peak performance, mitochondrial health is the common denominator. This solosode blends research, actionable insights, and clinical tools to help you light up your health from the inside out.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 02:13 – Biohacking Conference Recap 03:21 – Return to Nature Retreat Preview 04:43 – Limonin's Anti-Inflammatory Effects 06:06 – Limonin Health Benefits Overview 09:06 – BioBlue Fountain of Youth Supplement 11:48 – Limonin Study Insights 13:48 – Neuroinflammation & Mitochondrial Stress 16:48 – Therapies for Neurodegenerative Diseases 19:01 – Mitochondrial Function in Allergic Asthma 21:27 – Asthma Treatment Strategies 23:52 – Photo Biomodulation & Gut Microbiota 25:53 – How Red Light Restores Gut Balance 28:36 – C60 Fullerenes for Muscle Recovery 31:00 – C60 Reduces Fibrosis in Muscle 33:49 – Red Light Cupping System Benefits 36:37 – Cupping for Athletic Recovery 39:55 – C60 for Athletic Performance 42:26 – Methylene Blue & Athletic Enhancement 44:20 – Episode Wrap-Up & Key Takeaways - Articles referenced in episode: Limonin Exhibits Anti-Inflammatory Effects by Inhibiting mTORC1 and Mitochondrial Reactive Oxygen Species in Psoriatic-like Skin Inflammation   Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress   Targeting mitochondrial function as a potential therapeutic approach for allergic asthma   Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation   C60 fullerene promotes post-traumatic recovery of the rat muscle gastrocnemius - Unparalleled Mitochondrial Support: BioBlue Fountain of Youth   Save 15% on your order of the Fountain of YouthCode: FOY15ORSave 25% when you purchase the Fountain of Youth via the BioBundle and choose the subscription option!No code necessary -- 25% discount automatically applied!   Shop Fountain of Youth by clicking here. Shop BioBundle by clicking here. - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

This episode is brought to you by Fatty15, Pique, and Strong Coffee. Neuronutritionist Timothy Frie joins us today to delve into the intricate connections between dietary choices, trauma, and brain health. Tim shares his expertise on how our eating behaviors are often unconsciously shaped by past trauma, stress, and grief, emphasizing the importance of neuro nutrition in healing and recovery. The discussion highlights the transformative power of the MIND diet, which integrates Mediterranean and DASH dietary principles, to enhance mental well-being. We explore the challenges faced by individuals with chronic illnesses and mental health conditions, focusing on the nutritional needs of the brain and nervous system. Key topics include the Cell Danger Response, the impact of protein and micronutrient deficiencies, and the role of neuroplasticity in trauma recovery. The episode underscores the significance of personalizing nutrition to support cognitive function and overall well-being, advocating for a varied and colorful diet to optimize mental health. Follow Tim @timothyfrie Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Understanding Nutrition's Impact on Brain Health (13:19) Nutrition's Role in Brain Function (18:35) Neuronutrition and Traumatic Stress (22:35) Cell Danger Response and Health Challenges (28:21) Nutrition, Brain Health, and Wellbeing (37:05) Protein Deficiency's Impact on Cognitive Function (43:11) Neuroinflammation and Nutrient Deficiency (47:40) Nutrition, Trauma, and Stress Impact (57:55) Understanding Trauma, Neuroplasticity, and Nutrition (01:05:35) Trauma, Therapy, and Neuroplasticity (01:17:36) Supplementation and Trauma (01:24:41) Exploring Neuro Nutrition and Curiosity ---- Episode resources: Save 20% for life on organic teas and drinks at https://www.PiqueLife.com/everforward Save 15% on C15:0 essential fatty acids with code EVERFORWARD at https://www.Fatty15.com/everforward Save 15% on organic lattes and coffee with code CHASE at https://www.StrongCoffeeCompany.com  Watch and subscribe on YouTube Learn more at TimFrie.com

Dr Austin Perlmutter, neurobiology, mood and decision-making expert, joins our ambassador Dr Adrian Lopresti as they explore the biological basis of “stuckness” in the mind and how the brain is influenced by inflammatory/immune triggers which results is certain behaviours and health outcomes. Together they discuss the relationship between sickness behaviour, neuroinflammation and their effect on the brain leading to our inherent tendency to return to “default”. Nature vs nurture is discussed where exposures from foetal development, childhood trauma and genetic influences can impact our mental and cognitive flexibility much later in life. Austin explains “disconnection syndrome” a modern conundrum where our brains tend to latch onto impulsive behaviours leading to cognitive decline. It's not all doom and gloom as Austin and Adrian bring practical solutions to the table in the form of simple lifestyle adjustments that promotes behavioural change and reduce neuroinflammation. COVERED IN THIS EPISODE (00:55) Welcoming Dr Austin Perlmutter (01:42) Preventing chronic disease and reduced brain function (05:32) Sickness behaviour and the impacts of inflammation on the brain (08:48) How genetics and environment predispose us to increased risk of brain conditions (12:46) Does early life trauma increase our risk of developing mental health conditions? (15:28) The disconnection syndrome (18:57) Chronic stress induces brain atrophy (24:02) How inflammation impacts immunity (29:00) Connections between inflammation, impulsivity and decision making (35:07) Effects of inflammation on sleep and neuroplasticity (41:05) Food for brain health (48:34) Supplementation to improve brain function and reduce inflammation (51:24) Implementing lifestyle changes and resources for practitioners (56:00) Thanking Austin and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/neuroinflammation-impacts-on-immunity-behaviour-brain-function-with-dr-adrian-lopresti-dr-austin-perlmutter Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

Big shift in Alzheimer's care! We can now predict it years in advance using

What if healing didn't start with supplements, but with a shift in thought? In this episode of the Smarter Not Harder Podcast, Dr. Scott Sherr sits down with renegade nurse and educator Karen DiMarco to explore how psychosocial stress, identity, and hypervigilance can create—or dissolve—chronic illness. Karen shares her personal health journey, the groundbreaking chronic fatigue study she co-led, and why our thoughts may be the most overlooked variable in healing. Join us as we delve into: The story behind Karen's recovery from chronic fatigue syndrome Her radical 8-week study that helped patients recover—without meds or supplements The connection between thought, oxidative stress, and the cell danger response How metaphors and insight can rewire the brain and physiology This episode is for you if: You've struggled with chronic illness and feel stuck You're curious about the mind-body connection in healing You're a health professional working with complex, hard-to-treat patients You want to learn how to “collapse the gap” between who you are and who you think you should be You can also find this episode on… YouTube: https://youtu.be/RAdH75quOzM Find more from Karen DiMarco: Website: https://karendimarco.com/home/ RNegade.pro: https://rnegade.pro/ LinkedIn: https://www.linkedin.com/in/karen-dimarco-rnegade/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

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Send us a textEpisode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits.About the guest: Michael Wheeler, PhD is an Assistant Professor of Neurology at Harvard Medical School. His lab studies how immune responses influence behavior, mood disorders, and addiction.Key Conversation Points:The blood-brain barrier (BBB) is not as impermeable as once thought, allowing immune signals like cytokines to influence brain function even in healthy states.Chronic stress can weaken the BBB, increasing inflammation and affecting mood-regulating circuits, potentially contributing to depression.Microglia, the brain's resident immune cells, help maintain neural circuits by pruning synapses and regulating metabolism.Psychedelics like psilocybin and MDMA can reduce inflammation by prompting immune cells (monocytes) to leave the meninges, potentially via vascular effects.These psychedelics may act in a context-specific “window,” requiring a dysregulated tissue state to exert anti-inflammatory effects, not as broad-spectrum anti-inflammatories.Neuroinflammation may underlie some treatment-resistant depression cases, suggesting immunotherapy could complement traditional psychiatric treatments.The brain encodes peripheral immune signals, like gut inflammation, in specific circuits, which can “remember” and recreate inflammatory responses.Aging may naturally increase blood-brain barrier leakiness, heightening the brain's susceptibility to peripheral inflammation.Future research aims to explore how psychedelics influence plasticity and their potential in treating inflammation-related diseases beyond psychiatry.Related episode:M&M 2: Psilocybin, LSD, Ketamine, Inflammation & Novel Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

For clinicians in functional medicine, these cases are all too familiar. While antibiotics, herbal medicines, biofilm disruptors, and immune support are key in managing Lyme disease, restoring quality sleep is just as essential. Without sleep, healing stalls. It is during deep sleep that glymphatic clearance occurs, immune cells regenerate, and the nervous system resets. Herbal solutions can help patients with Lyme-related insomnia achieve deep, restorative sleep. This article explores how Lyme disrupts sleep physiology and how Moss Nutrition's new Sleep Select Herbal—a blend of saffron, valerian, American skullcap, passionflower, and Ziziphus spinosa—can help restore calm and rest. These botanicals are supported by clinical trials and tailored to address the unique neuroimmune dysregulation seen in Lyme disease. The Limits of Conventional Sleep Aids Many Lyme patients are prescribed benzodiazepines, sedative antihistamines, or off-label antidepressants for insomnia. While these may offer temporary relief, they rarely address root causes. Over time, they can disrupt sleep architecture, desensitize GABA receptors, and create dependency or withdrawal problems. By contrast, botanical nervines and adaptogens support endogenous pathways—enhancing GABA, modulating cortisol, and recalibrating circadian rhythm—without suppressing natural neurotransmission. This is the core strategy behind Sleep Select Herbal. How Lyme Disease Disrupts Sleep and Creates Nervous Tension 1. Neuroinflammation and Cytokine Overload Borrelia and its coinfections invade the central nervous system, triggering microglial activation and the release of inflammatory cytokines like IL-6, TNF-alpha, and IL-1β. These cytokines interfere with the function of sleep-promoting areas in the brain, such as the hypothalamus and suprachiasmatic nucleus. Impact: Reduced sleep drive, disrupted circadian signaling, and altered neurotransmitter synthesis. 2. Cortisol Dysregulation and HPA Axis Dysfunction Patients with chronic Lyme disease often exhibit abnormal cortisol rhythms—typically low in the morning and elevated at night. This flipped curve perpetuates insomnia, often manifesting as nighttime awakenings or difficulty falling asleep. Impact: Low melatonin, nighttime anxiety, impaired parasympathetic tone, and reduced vagal tone. 3. GABA and Serotonin Imbalance Lyme disease inflammation can disrupt the synthesis and receptor sensitivity of GABA and serotonin—the primary calming neurotransmitters. This leads to hyperarousal, panic, and light, unrefreshing sleep. Impact: Reduced GABAergic tone increases muscle tension, rumination, and sympathetic dominance. Five Botanicals to Restore Sleep in Lyme Disease Each herb in Sleep Select Herbal addresses a distinct but overlapping mechanism contributing to insomnia and nervous tension. Clinically formulated Sleep Select Herbal supports deep, restorative sleep for patients with Lyme-related insomnia and nervous tension. 1. Saffron (Crocus sativus) – The Circadian Calibrator In a 2021 double-blind, placebo-controlled study of 120 adults with poor sleep, saffron (affron®) at 14–28 mg improved sleep quality, reduced insomnia severity, and increased evening melatonin levels without next-day sedation (Lopresti et al., 2021). Mechanisms: Increases nighttime melatonin Reduces evening cortisol Improves sleep onset and continuity Patient Profile: Individuals with delayed sleep phase, high evening cortisol, or mood disturbances upon waking. 2. Valerian (Valeriana officinalis) – The GABAergic Grounder Valerian root enhances GABA signaling by inhibiting its breakdown and modulating GABA-A receptors. A clinical trial showed valerian significantly improved total sleep time, reduced latency, and enhanced sleep efficiency (Shekhar et al., 2024). Mechanisms: Binds GABA-A receptors without habituation Reduces anxiety and muscle tension

In this episode of the RWS Clinician's Corner, Margaret and Brendan explore the powerful connection between metabolic health and mental well-being, revealing why mental health isn't just about psychology—but also about our biology. Brendan breaks down his “three pillars” model for true mental wellness, walks us through nuanced approaches to lab testing, and explains why functional practitioners should be both evidence-based and deeply empathetic.    In this interview, we discuss:  Brendan's early experiences with mental health struggles and his challenges with the conventional psychiatric approaches  The importance of distinguishing between psycho-emotional issues and neurological/physiological health The role of objective biomarkers in validating client experiences, as well as the potential pitfalls of over-identification with laboratory findings  Recognizing when to refer clients to mental health professionals  Techniques for addressing emotionally charged or traumatic material during sessions The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/ Note: This episode contains discussions about suicide, which may be distressing to some listeners. Please take care of yourself and feel free to pause or skip this episode if needed. If you, a client, or someone you know is struggling with thoughts of suicide, help is available. Here is a list of free, confidential resources available 24/7: 988 Suicide & Crisis Lifeline: Call or text 988, or chat online at 988lifeline.org      -Crisis Text Line: Text HOME to 741741 to connect with a trained counselor      -The Trevor Project (for LGBTQ+ youth): Call 1-866-488-7386 or text START to 678-678 These services are here to support you anytime, anywhere. Remember, reaching out for help is a sign of strength.   Connect with Brendan Vermeire: Website: www.metabolicsolutionsllc.com Instagram: https://www.instagram.com/the_holistic_savage/   Use the discount code RW25 to get Brendan's FMHP Workshop Series for FREE: https://holisticsavage.kartra.com/page/FMHP-workshop   Timestamps:  00:00 "Functional Mental Health Insights" 05:46 "Passion for Healing Amid Struggle" 10:01 "Bridging Science with Spiritual Fitness" 13:28 "Mind-Body Connection Explored" 16:31 Objective Biomarkers vs. Mysterious Diagnoses 19:22 Navigating Functional Medicine Challenges 21:09 Mycotoxin Tests: Limited Diagnostic Insight 27:17 Neuroinflammation and Immune Biomarkers 30:11 Rethinking Lab Test Investments 32:52 Clinical Intake and Lifestyle Assessment 36:29 "Effective Patient Engagement Strategies" 41:13 Essential Advice for Health Practitioners 43:21 Bridging Coaching and Functional Medicine 46:14 "Understanding Test Limitations in Health" 49:43 Functional Mental Health Training Program 52:24 "Listener Requests and Gratitude" Speaker bio: Brendan Vermeire is a Clinical Researcher, Functional Medicine Practitioner & Educator, passionate about teaching a root-cause approach to mental and metabolic Illness. He is the proud owner of the Metabolic Solutions Institute, home of the Functional Mental Health Practitioner Certificate Program.   Keywords: metabolic health, mental health, functional medicine, biomarkers, neurological health, psycho-emotional health, lab testing, suicidal ideation, root cause medicine, functional practitioners, SSRI, psychiatric drugs, metabolic markers, personal training, clinical research, depression, anxiety, neuroinflammation, microbiome, mindset, metabolic dysfunction, mold illness, mycotoxins, stool testing, coaching, motivational interviewing, C-reactive protein, neurofilament light chain, neurotransmitters, patient compliance   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

On this week's episode of the Real Health Co. Podcast, Dr. Barrett starts a series on neuroinflammation and how to combat it before it leads to chronic conditions. All of this and more on the Real Health Co. Podcast!

Story at-a-glance Gut bacteria called Morganella morganii produce unusual fats that contain diethanolamine (DEA), an environmental micropollutant; the fats trigger inflammation that contribute to major depressive disorder The gut-brain axis operates bidirectionally — gut dysbiosis causes systemic inflammation that affects your brain while brain inflammation disrupts gut health Disruptions in gut bacteria lead to increased intestinal permeability, or "leaky gut," which allows harmful substances to enter your bloodstream and trigger systemic inflammation Neuroinflammation shifts tryptophan metabolism toward the kynurenine pathway, which produces substances that contribute to glutamate excitotoxicity, in turn damaging brain cells and contributing to depression Restoring gut health requires a comprehensive approach, including eliminating seed oils, avoiding endocrine disruptors, optimizing carbohydrate intake and carefully introducing beneficial bacteria like Akkermansia muciniphila

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you'd like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today's episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger's traits through neuroplasticity and mitochondrial upgrades. There's even some great advice for all the parents out there! What You'll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave's personal take • How mitochondria impact brain power, mood, and aging—and how to fix them today! • The shocking reason some people can't process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Upgrade Collective Membership: https://www.ourupgradecollective.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger's Syndrome and Neuroinflammation • 28:53 – Understanding Asperger's and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.