Podcasts about Neuroinflammation

This episode is brought to you by Fatty15, Pique, and Strong Coffee. Neuronutritionist Timothy Frie joins us today to delve into the intricate connections between dietary choices, trauma, and brain health. Tim shares his expertise on how our eating behaviors are often unconsciously shaped by past trauma, stress, and grief, emphasizing the importance of neuro nutrition in healing and recovery. The discussion highlights the transformative power of the MIND diet, which integrates Mediterranean and DASH dietary principles, to enhance mental well-being. We explore the challenges faced by individuals with chronic illnesses and mental health conditions, focusing on the nutritional needs of the brain and nervous system. Key topics include the Cell Danger Response, the impact of protein and micronutrient deficiencies, and the role of neuroplasticity in trauma recovery. The episode underscores the significance of personalizing nutrition to support cognitive function and overall well-being, advocating for a varied and colorful diet to optimize mental health. Follow Tim @timothyfrie Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Understanding Nutrition's Impact on Brain Health (13:19) Nutrition's Role in Brain Function (18:35) Neuronutrition and Traumatic Stress (22:35) Cell Danger Response and Health Challenges (28:21) Nutrition, Brain Health, and Wellbeing (37:05) Protein Deficiency's Impact on Cognitive Function (43:11) Neuroinflammation and Nutrient Deficiency (47:40) Nutrition, Trauma, and Stress Impact (57:55) Understanding Trauma, Neuroplasticity, and Nutrition (01:05:35) Trauma, Therapy, and Neuroplasticity (01:17:36) Supplementation and Trauma (01:24:41) Exploring Neuro Nutrition and Curiosity ---- Episode resources: Save 20% for life on organic teas and drinks at https://www.PiqueLife.com/everforward Save 15% on C15:0 essential fatty acids with code EVERFORWARD at https://www.Fatty15.com/everforward Save 15% on organic lattes and coffee with code CHASE at https://www.StrongCoffeeCompany.com  Watch and subscribe on YouTube Learn more at TimFrie.com

Dr Austin Perlmutter, neurobiology, mood and decision-making expert, joins our ambassador Dr Adrian Lopresti as they explore the biological basis of “stuckness” in the mind and how the brain is influenced by inflammatory/immune triggers which results is certain behaviours and health outcomes. Together they discuss the relationship between sickness behaviour, neuroinflammation and their effect on the brain leading to our inherent tendency to return to “default”. Nature vs nurture is discussed where exposures from foetal development, childhood trauma and genetic influences can impact our mental and cognitive flexibility much later in life. Austin explains “disconnection syndrome” a modern conundrum where our brains tend to latch onto impulsive behaviours leading to cognitive decline. It's not all doom and gloom as Austin and Adrian bring practical solutions to the table in the form of simple lifestyle adjustments that promotes behavioural change and reduce neuroinflammation. COVERED IN THIS EPISODE (00:55) Welcoming Dr Austin Perlmutter (01:42) Preventing chronic disease and reduced brain function (05:32) Sickness behaviour and the impacts of inflammation on the brain (08:48) How genetics and environment predispose us to increased risk of brain conditions (12:46) Does early life trauma increase our risk of developing mental health conditions? (15:28) The disconnection syndrome (18:57) Chronic stress induces brain atrophy (24:02) How inflammation impacts immunity (29:00) Connections between inflammation, impulsivity and decision making (35:07) Effects of inflammation on sleep and neuroplasticity (41:05) Food for brain health (48:34) Supplementation to improve brain function and reduce inflammation (51:24) Implementing lifestyle changes and resources for practitioners (56:00) Thanking Austin and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/neuroinflammation-impacts-on-immunity-behaviour-brain-function-with-dr-adrian-lopresti-dr-austin-perlmutter Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

What if healing didn't start with supplements, but with a shift in thought? In this episode of the Smarter Not Harder Podcast, Dr. Scott Sherr sits down with renegade nurse and educator Karen DiMarco to explore how psychosocial stress, identity, and hypervigilance can create—or dissolve—chronic illness. Karen shares her personal health journey, the groundbreaking chronic fatigue study she co-led, and why our thoughts may be the most overlooked variable in healing. Join us as we delve into: The story behind Karen's recovery from chronic fatigue syndrome Her radical 8-week study that helped patients recover—without meds or supplements The connection between thought, oxidative stress, and the cell danger response How metaphors and insight can rewire the brain and physiology This episode is for you if: You've struggled with chronic illness and feel stuck You're curious about the mind-body connection in healing You're a health professional working with complex, hard-to-treat patients You want to learn how to “collapse the gap” between who you are and who you think you should be You can also find this episode on… YouTube: https://youtu.be/RAdH75quOzM Find more from Karen DiMarco: Website: https://karendimarco.com/home/ RNegade.pro: https://rnegade.pro/ LinkedIn: https://www.linkedin.com/in/karen-dimarco-rnegade/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

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Send us a textEpisode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits.About the guest: Michael Wheeler, PhD is an Assistant Professor of Neurology at Harvard Medical School. His lab studies how immune responses influence behavior, mood disorders, and addiction.Key Conversation Points:The blood-brain barrier (BBB) is not as impermeable as once thought, allowing immune signals like cytokines to influence brain function even in healthy states.Chronic stress can weaken the BBB, increasing inflammation and affecting mood-regulating circuits, potentially contributing to depression.Microglia, the brain's resident immune cells, help maintain neural circuits by pruning synapses and regulating metabolism.Psychedelics like psilocybin and MDMA can reduce inflammation by prompting immune cells (monocytes) to leave the meninges, potentially via vascular effects.These psychedelics may act in a context-specific “window,” requiring a dysregulated tissue state to exert anti-inflammatory effects, not as broad-spectrum anti-inflammatories.Neuroinflammation may underlie some treatment-resistant depression cases, suggesting immunotherapy could complement traditional psychiatric treatments.The brain encodes peripheral immune signals, like gut inflammation, in specific circuits, which can “remember” and recreate inflammatory responses.Aging may naturally increase blood-brain barrier leakiness, heightening the brain's susceptibility to peripheral inflammation.Future research aims to explore how psychedelics influence plasticity and their potential in treating inflammation-related diseases beyond psychiatry.Related episode:M&M 2: Psilocybin, LSD, Ketamine, Inflammation & Novel Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

For clinicians in functional medicine, these cases are all too familiar. While antibiotics, herbal medicines, biofilm disruptors, and immune support are key in managing Lyme disease, restoring quality sleep is just as essential. Without sleep, healing stalls. It is during deep sleep that glymphatic clearance occurs, immune cells regenerate, and the nervous system resets. Herbal solutions can help patients with Lyme-related insomnia achieve deep, restorative sleep. This article explores how Lyme disrupts sleep physiology and how Moss Nutrition's new Sleep Select Herbal—a blend of saffron, valerian, American skullcap, passionflower, and Ziziphus spinosa—can help restore calm and rest. These botanicals are supported by clinical trials and tailored to address the unique neuroimmune dysregulation seen in Lyme disease. The Limits of Conventional Sleep Aids Many Lyme patients are prescribed benzodiazepines, sedative antihistamines, or off-label antidepressants for insomnia. While these may offer temporary relief, they rarely address root causes. Over time, they can disrupt sleep architecture, desensitize GABA receptors, and create dependency or withdrawal problems. By contrast, botanical nervines and adaptogens support endogenous pathways—enhancing GABA, modulating cortisol, and recalibrating circadian rhythm—without suppressing natural neurotransmission. This is the core strategy behind Sleep Select Herbal. How Lyme Disease Disrupts Sleep and Creates Nervous Tension 1. Neuroinflammation and Cytokine Overload Borrelia and its coinfections invade the central nervous system, triggering microglial activation and the release of inflammatory cytokines like IL-6, TNF-alpha, and IL-1β. These cytokines interfere with the function of sleep-promoting areas in the brain, such as the hypothalamus and suprachiasmatic nucleus. Impact: Reduced sleep drive, disrupted circadian signaling, and altered neurotransmitter synthesis. 2. Cortisol Dysregulation and HPA Axis Dysfunction Patients with chronic Lyme disease often exhibit abnormal cortisol rhythms—typically low in the morning and elevated at night. This flipped curve perpetuates insomnia, often manifesting as nighttime awakenings or difficulty falling asleep. Impact: Low melatonin, nighttime anxiety, impaired parasympathetic tone, and reduced vagal tone. 3. GABA and Serotonin Imbalance Lyme disease inflammation can disrupt the synthesis and receptor sensitivity of GABA and serotonin—the primary calming neurotransmitters. This leads to hyperarousal, panic, and light, unrefreshing sleep. Impact: Reduced GABAergic tone increases muscle tension, rumination, and sympathetic dominance. Five Botanicals to Restore Sleep in Lyme Disease Each herb in Sleep Select Herbal addresses a distinct but overlapping mechanism contributing to insomnia and nervous tension. Clinically formulated Sleep Select Herbal supports deep, restorative sleep for patients with Lyme-related insomnia and nervous tension. 1. Saffron (Crocus sativus) – The Circadian Calibrator In a 2021 double-blind, placebo-controlled study of 120 adults with poor sleep, saffron (affron®) at 14–28 mg improved sleep quality, reduced insomnia severity, and increased evening melatonin levels without next-day sedation (Lopresti et al., 2021). Mechanisms: Increases nighttime melatonin Reduces evening cortisol Improves sleep onset and continuity Patient Profile: Individuals with delayed sleep phase, high evening cortisol, or mood disturbances upon waking. 2. Valerian (Valeriana officinalis) – The GABAergic Grounder Valerian root enhances GABA signaling by inhibiting its breakdown and modulating GABA-A receptors. A clinical trial showed valerian significantly improved total sleep time, reduced latency, and enhanced sleep efficiency (Shekhar et al., 2024). Mechanisms: Binds GABA-A receptors without habituation Reduces anxiety and muscle tension

In this episode of the RWS Clinician's Corner, Margaret and Brendan explore the powerful connection between metabolic health and mental well-being, revealing why mental health isn't just about psychology—but also about our biology. Brendan breaks down his “three pillars” model for true mental wellness, walks us through nuanced approaches to lab testing, and explains why functional practitioners should be both evidence-based and deeply empathetic.    In this interview, we discuss:  Brendan's early experiences with mental health struggles and his challenges with the conventional psychiatric approaches  The importance of distinguishing between psycho-emotional issues and neurological/physiological health The role of objective biomarkers in validating client experiences, as well as the potential pitfalls of over-identification with laboratory findings  Recognizing when to refer clients to mental health professionals  Techniques for addressing emotionally charged or traumatic material during sessions The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/ Note: This episode contains discussions about suicide, which may be distressing to some listeners. Please take care of yourself and feel free to pause or skip this episode if needed. If you, a client, or someone you know is struggling with thoughts of suicide, help is available. Here is a list of free, confidential resources available 24/7: 988 Suicide & Crisis Lifeline: Call or text 988, or chat online at 988lifeline.org      -Crisis Text Line: Text HOME to 741741 to connect with a trained counselor      -The Trevor Project (for LGBTQ+ youth): Call 1-866-488-7386 or text START to 678-678 These services are here to support you anytime, anywhere. Remember, reaching out for help is a sign of strength.   Connect with Brendan Vermeire: Website: www.metabolicsolutionsllc.com Instagram: https://www.instagram.com/the_holistic_savage/   Use the discount code RW25 to get Brendan's FMHP Workshop Series for FREE: https://holisticsavage.kartra.com/page/FMHP-workshop   Timestamps:  00:00 "Functional Mental Health Insights" 05:46 "Passion for Healing Amid Struggle" 10:01 "Bridging Science with Spiritual Fitness" 13:28 "Mind-Body Connection Explored" 16:31 Objective Biomarkers vs. Mysterious Diagnoses 19:22 Navigating Functional Medicine Challenges 21:09 Mycotoxin Tests: Limited Diagnostic Insight 27:17 Neuroinflammation and Immune Biomarkers 30:11 Rethinking Lab Test Investments 32:52 Clinical Intake and Lifestyle Assessment 36:29 "Effective Patient Engagement Strategies" 41:13 Essential Advice for Health Practitioners 43:21 Bridging Coaching and Functional Medicine 46:14 "Understanding Test Limitations in Health" 49:43 Functional Mental Health Training Program 52:24 "Listener Requests and Gratitude" Speaker bio: Brendan Vermeire is a Clinical Researcher, Functional Medicine Practitioner & Educator, passionate about teaching a root-cause approach to mental and metabolic Illness. He is the proud owner of the Metabolic Solutions Institute, home of the Functional Mental Health Practitioner Certificate Program.   Keywords: metabolic health, mental health, functional medicine, biomarkers, neurological health, psycho-emotional health, lab testing, suicidal ideation, root cause medicine, functional practitioners, SSRI, psychiatric drugs, metabolic markers, personal training, clinical research, depression, anxiety, neuroinflammation, microbiome, mindset, metabolic dysfunction, mold illness, mycotoxins, stool testing, coaching, motivational interviewing, C-reactive protein, neurofilament light chain, neurotransmitters, patient compliance   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

En este episodio, profundizamos en uno de los fenómenos más devastadores pero menos comprendidos en neurorrehabilitación: la denervación muscular tras una lesión medular. A través de una revisión exhaustiva de la literatura científica y de la experiencia clínica, abordamos qué ocurre realmente con los músculos que han perdido su inervación, cómo se transforman con el tiempo y qué posibilidades tenemos para intervenir. Hablamos sobre neurofisiología, degeneración axonal, fases de la denervación, y cómo la estimulación eléctrica —especialmente con pulsos largos— puede modificar el curso degenerativo incluso años después de la lesión. Exploramos también el Proyecto RISE, los protocolos clínicos actuales y las implicaciones terapéuticas reales de aplicar electroestimulación en músculos completamente denervados. Si trabajas en neurorrehabilitación o te interesa la ciencia aplicada a la recuperación funcional, este episodio es para ti. Referencias del episodio: 1. Alberty, M., Mayr, W., & Bersch, I. (2023). Electrical Stimulation for Preventing Skin Injuries in Denervated Gluteal Muscles-Promising Perspectives from a Case Series and Narrative Review. Diagnostics (Basel, Switzerland), 13(2), 219. https://doi.org/10.3390/diagnostics13020219 (https://pubmed.ncbi.nlm.nih.gov/36673029/). 2. Beauparlant, J., van den Brand, R., Barraud, Q., Friedli, L., Musienko, P., Dietz, V., & Courtine, G. (2013). Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury. Brain : a journal of neurology, 136(Pt 11), 3347–3361. https://doi.org/10.1093/brain/awt204 (https://pubmed.ncbi.nlm.nih.gov/24080153/). 3. Bersch, I., & Fridén, J. (2021). Electrical stimulation alters muscle morphological properties in denervated upper limb muscles. EBioMedicine, 74, 103737. https://doi.org/10.1016/j.ebiom.2021.103737 (https://pubmed.ncbi.nlm.nih.gov/34896792/). 4. Bersch, I., & Mayr, W. (2023). Electrical stimulation in lower motoneuron lesions, from scientific evidence to clinical practice: a successful transition. European journal of translational myology, 33(2), 11230. https://doi.org/10.4081/ejtm.2023.11230 (https://pmc.ncbi.nlm.nih.gov/articles/PMC10388603/). 5. Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364 (Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364). 6. Carlson B. M. (2014). The Biology of Long-Term Denervated Skeletal Muscle. European journal of translational myology, 24(1), 3293. https://doi.org/10.4081/ejtm.2014.3293 (https://pubmed.ncbi.nlm.nih.gov/26913125/). 7. Carraro, U., Boncompagni, S., Gobbo, V., Rossini, K., Zampieri, S., Mosole, S., Ravara, B., Nori, A., Stramare, R., Ambrosio, F., Piccione, F., Masiero, S., Vindigni, V., Gargiulo, P., Protasi, F., Kern, H., Pond, A., & Marcante, A. (2015). Persistent Muscle Fiber Regeneration in Long Term Denervation. Past, Present, Future. European journal of translational myology, 25(2), 4832. https://doi.org/10.4081/ejtm.2015.4832 (https://pubmed.ncbi.nlm.nih.gov/26913148/). 8. Chandrasekaran, S., Davis, J., Bersch, I., Goldberg, G., & Gorgey, A. S. (2020). Electrical stimulation and denervated muscles after spinal cord injury. Neural regeneration research, 15(8), 1397–1407. https://doi.org/10.4103/1673-5374.274326 (https://pubmed.ncbi.nlm.nih.gov/31997798/). 9. Ding, Y., Kastin, A. J., & Pan, W. (2005). Neural plasticity after spinal cord injury. Current pharmaceutical design, 11(11), 1441–1450. https://doi.org/10.2174/1381612053507855 (https://pmc.ncbi.nlm.nih.gov/articles/PMC3562709/). 10. Dolbow, D. R., Bersch, I., Gorgey, A. S., & Davis, G. M. (2024). The Clinical Management of Electrical Stimulation Therapies in the Rehabilitation of Individuals with Spinal Cord Injuries. Journal of clinical medicine, 13(10), 2995. https://doi.org/10.3390/jcm13102995 (https://pubmed.ncbi.nlm.nih.gov/38792536/). 11. Hofer, C., Mayr, W., Stöhr, H., Unger, E., & Kern, H. (2002). A stimulator for functional activation of denervated muscles. Artificial organs, 26(3), 276–279. https://doi.org/10.1046/j.1525-1594.2002.06951.x (https://pubmed.ncbi.nlm.nih.gov/11940032/). 12. Kern, H., Hofer, C., Mödlin, M., Forstner, C., Raschka-Högler, D., Mayr, W., & Stöhr, H. (2002). Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols. Artificial organs, 26(3), 216–218. https://doi.org/10.1046/j.1525-1594.2002.06933.x (https://pubmed.ncbi.nlm.nih.gov/11940016/). 13. Kern, H., Salmons, S., Mayr, W., Rossini, K., & Carraro, U. (2005). Recovery of long-term denervated human muscles induced by electrical stimulation. Muscle & nerve, 31(1), 98–101. https://doi.org/10.1002/mus.20149 (https://pubmed.ncbi.nlm.nih.gov/15389722/). 14. Kern, H., Rossini, K., Carraro, U., Mayr, W., Vogelauer, M., Hoellwarth, U., & Hofer, C. (2005). Muscle biopsies show that FES of denervated muscles reverses human muscle degeneration from permanent spinal motoneuron lesion. Journal of rehabilitation research and development, 42(3 Suppl 1), 43–53. https://doi.org/10.1682/jrrd.2004.05.0061 (https://pubmed.ncbi.nlm.nih.gov/16195962/). 15. Kern, H., Carraro, U., Adami, N., Hofer, C., Loefler, S., Vogelauer, M., Mayr, W., Rupp, R., & Zampieri, S. (2010). One year of home-based daily FES in complete lower motor neuron paraplegia: recovery of tetanic contractility drives the structural improvements of denervated muscle. Neurological research, 32(1), 5–12. https://doi.org/10.1179/174313209X385644 (https://pubmed.ncbi.nlm.nih.gov/20092690/). 16. Kern, H., & Carraro, U. (2014). Home-Based Functional Electrical Stimulation for Long-Term Denervated Human Muscle: History, Basics, Results and Perspectives of the Vienna Rehabilitation Strategy. European journal of translational myology, 24(1), 3296. https://doi.org/10.4081/ejtm.2014.3296 (https://pmc.ncbi.nlm.nih.gov/articles/PMC4749003/). 17. Kern, H., Hofer, C., Loefler, S., Zampieri, S., Gargiulo, P., Baba, A., Marcante, A., Piccione, F., Pond, A., & Carraro, U. (2017). Atrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017. Neurological research, 39(7), 660–666. https://doi.org/10.1080/01616412.2017.1314906 (https://pubmed.ncbi.nlm.nih.gov/28403681/). 18. Kern, H., & Carraro, U. (2020). Home-Based Functional Electrical Stimulation of Human Permanent Denervated Muscles: A Narrative Review on Diagnostics, Managements, Results and Byproducts Revisited 2020. Diagnostics (Basel, Switzerland), 10(8), 529. https://doi.org/10.3390/diagnostics10080529 (https://pubmed.ncbi.nlm.nih.gov/32751308/). 19. Ko H. Y. (2018). Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock. Korean journal of neurotrauma, 14(2), 47–54. https://doi.org/10.13004/kjnt.2018.14.2.47 (https://pubmed.ncbi.nlm.nih.gov/30402418/). 20. Mittal, P., Gupta, R., Mittal, A., & Mittal, K. (2016). MRI findings in a case of spinal cord Wallerian degeneration following trauma. Neurosciences (Riyadh, Saudi Arabia), 21(4), 372–373. https://doi.org/10.17712/nsj.2016.4.20160278 (https://pmc.ncbi.nlm.nih.gov/articles/PMC5224438/). 21. Pang, Q. M., Chen, S. Y., Xu, Q. J., Fu, S. P., Yang, Y. C., Zou, W. H., Zhang, M., Liu, J., Wan, W. H., Peng, J. C., & Zhang, T. (2021). Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar. Frontiers in immunology, 12, 751021. https://doi.org/10.3389/fimmu.2021.751021 (https://pubmed.ncbi.nlm.nih.gov/34925326/). 22. Schick, T. (Ed.). (2022). Functional electrical stimulation in neurorehabilitation: Synergy effects of technology and therapy. Springer. https://doi.org/10.1007/978-3-030-90123-3 (https://link.springer.com/book/10.1007/978-3-030-90123-3). 23. Swain, I., Burridge, J., & Street, T. (Eds.). (2024). Techniques and technologies in electrical stimulation for neuromuscular rehabilitation. The Institution of Engineering and Technology. https://shop.theiet.org/techniques-and-technologies-in-electrical-stimulation-for-neuromuscular-rehabilitation 24. van der Scheer, J. W., Goosey-Tolfrey, V. L., Valentino, S. E., Davis, G. M., & Ho, C. H. (2021). Functional electrical stimulation cycling exercise after spinal cord injury: a systematic review of health and fitness-related outcomes. Journal of neuroengineering and rehabilitation, 18(1), 99. https://doi.org/10.1186/s12984-021-00882-8 (https://pubmed.ncbi.nlm.nih.gov/34118958/). 25. Xu, X., Talifu, Z., Zhang, C. J., Gao, F., Ke, H., Pan, Y. Z., Gong, H., Du, H. Y., Yu, Y., Jing, Y. L., Du, L. J., Li, J. J., & Yang, D. G. (2023). Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review. Frontiers in nutrition, 10, 1099143. https://doi.org/10.3389/fnut.2023.1099143 (https://pubmed.ncbi.nlm.nih.gov/36937344/). 26. Anatomical Concepts: https://www.anatomicalconcepts.com/articles

Tiziana Life Sciences CEO Ivor Elrifi joined Steve Darling from Proactive to share news the company has announced promising PET scan results from a patient with moderate Alzheimer's disease treated for three months with intranasal foralumab under an expanded access program. The scan revealed a significant reduction in microglial activation, a key marker of neuroinflammation linked to Alzheimer's progression. This outcome represents a major milestone for the company's intranasal foralumab program. With no approved therapies for moderate Alzheimer's disease, Tiziana sees foralumab—a fully human anti-CD3 monoclonal antibody—as a potential treatment option, both as a monotherapy and in combination with amyloid-targeting therapies. Foralumab has shown the ability to induce regulatory T cells (Tregs) that migrate to the brain and suppress neuroinflammation. These effects have been validated in preclinical models and in patients with secondary progressive multiple sclerosis, supporting further clinical development in neurodegenerative conditions. The company is set to begin a Phase 2 randomized, placebo-controlled trial in June 2025 involving mild Alzheimer's patients. Data from this trial are expected by the end of 2025. The aim is to determine if reducing neuroinflammation translates into improved quality of life. #proactiveinvestors #tizianalifescienceslts #nasdaq #tlsa #newceo #ivorelrifi #Foralumab #AlzheimersResearch #Neuroinflammation #BiotechNews #PETscan #ClinicalTrials #AlzheimersTreatment #PharmaUpdates #HealthcareInnovation

Discover the neurobiological secrets of revitalizing your mental battery with Michael Nehls, Ph.D. Learn how to harness the fountain of our mental energy, creativity, individuality, and motivation for better performance and well-being. Optimize your brain's potential today! #MentalEnergy #Neurobiology #Motivation

If you're juggling menopause, aging parents, and brain fog, this episode is for you. Today we explore how stimulating the vagus nerve — a key player in your nervous system — can lower inflammation, reduce anxiety, and improve your resilience to Alzheimer's disease. You'll walk away with actionable ways to feel better and think clearer, right now.What to Listen For[01:35] What is the vagus nerve — and no, it's not an anxious gambler

Brain Fog Breakthrough is a revolutionary audio experience engineered to clear mental haze and restore cognitive clarity. This soundscape combines calibrated frequencies to address brain fog from chronic illness, chemotherapy, fibromyalgia, and Long COVID.The track features a powerful frequency architecture:40Hz gamma stimulation – MIT research shows reduced neuroinflammation and enhanced cognition32Hz and 55Hz resonant frequencies – Amplify neural benefits23Hz binaural entrainment – Creates cross-hemispheric effects for mental acuityWhile traditional treatments focus on physical symptoms, this track targets neurological dimensions of cognitive dysfunction. Research shows 40Hz gamma frequency promotes neural plasticity and reduces inflammation, with MIT studies demonstrating 50% reductions in inflammatory markers and improved memory in chemotherapy models.Applications:Post-Chemotherapy: Support neural recoveryChronic Fatigue & Fibromyalgia: Reduce mental fatigueLong COVID: Address persistent cognitive challengesProfessional Focus: Enhance performance during demanding tasksAcademic Settings: Improve concentration (22% better retention with gamma frequencies)Morning Clarity: Overcome sleep inertia fasterStudies show participants exposed to similar frequencies experienced 40% lower cortisol levels and 75% better sleep quality, creating a foundation for enhanced cognition.The composition guides brainwaves from scattered to synchronized, working with your brain's natural neuroplasticity to establish clearer neural pathways.Recommended Use: Listen with quality headphones for 15-20 minutes before tasks requiring mental clarity or daily for chronic conditions.Experience the power of neuroscience with Brain Fog Breakthrough and rediscover mental clarity.Send us a textSupport the show

Brain Fog Breakthrough is a revolutionary audio experience engineered to clear mental haze and restore cognitive clarity. This soundscape combines calibrated frequencies to address brain fog from chronic illness, chemotherapy, fibromyalgia, and Long COVID.The track features a powerful frequency architecture:40Hz gamma stimulation – MIT research shows reduced neuroinflammation and enhanced cognition32Hz and 55Hz resonant frequencies – Amplify neural benefits23Hz binaural entrainment – Creates cross-hemispheric effects for mental acuityWhile traditional treatments focus on physical symptoms, this track targets neurological dimensions of cognitive dysfunction. Research shows 40Hz gamma frequency promotes neural plasticity and reduces inflammation, with MIT studies demonstrating 50% reductions in inflammatory markers and improved memory in chemotherapy models.Applications:Post-Chemotherapy: Support neural recoveryChronic Fatigue & Fibromyalgia: Reduce mental fatigueLong COVID: Address persistent cognitive challengesProfessional Focus: Enhance performance during demanding tasksAcademic Settings: Improve concentration (22% better retention with gamma frequencies)Morning Clarity: Overcome sleep inertia fasterStudies show participants exposed to similar frequencies experienced 40% lower cortisol levels and 75% better sleep quality, creating a foundation for enhanced cognition.The composition guides brainwaves from scattered to synchronized, working with your brain's natural neuroplasticity to establish clearer neural pathways.Recommended Use: Listen with quality headphones for 15-20 minutes before tasks requiring mental clarity or daily for chronic conditions.Experience the power of neuroscience with Brain Fog Breakthrough and rediscover mental clarity.Send us a textSupport the show

Subscriber-only episodeBrain Fog Breakthrough is a revolutionary audio experience engineered to clear mental haze and restore cognitive clarity. This soundscape combines calibrated frequencies to address brain fog from chronic illness, chemotherapy, fibromyalgia, and Long COVID.The track features a powerful frequency architecture:40Hz gamma stimulation – MIT research shows reduced neuroinflammation and enhanced cognition32Hz and 55Hz resonant frequencies – Amplify neural benefits23Hz binaural entrainment – Creates cross-hemispheric effects for mental acuityWhile traditional treatments focus on physical symptoms, this track targets neurological dimensions of cognitive dysfunction. Research shows 40Hz gamma frequency promotes neural plasticity and reduces inflammation, with MIT studies demonstrating 50% reductions in inflammatory markers and improved memory in chemotherapy models.Applications:Post-Chemotherapy: Support neural recoveryChronic Fatigue & Fibromyalgia: Reduce mental fatigueLong COVID: Address persistent cognitive challengesProfessional Focus: Enhance performance during demanding tasksAcademic Settings: Improve concentration (22% better retention with gamma frequencies)Morning Clarity: Overcome sleep inertia fasterStudies show participants exposed to similar frequencies experienced 40% lower cortisol levels and 75% better sleep quality, creating a foundation for enhanced cognition.The composition guides brainwaves from scattered to synchronized, working with your brain's natural neuroplasticity to establish clearer neural pathways.Recommended Use: Listen with quality headphones for 15-20 minutes before tasks requiring mental clarity or daily for chronic conditions.Experience the power of neuroscience with Brain Fog Breakthrough and rediscover mental clarity.Send us a text

Brain Fog Breakthrough is a revolutionary audio experience engineered to clear mental haze and restore cognitive clarity. This soundscape combines calibrated frequencies to address brain fog from chronic illness, chemotherapy, fibromyalgia, and Long COVID.The track features a powerful frequency architecture:40Hz gamma stimulation – MIT research shows reduced neuroinflammation and enhanced cognition32Hz and 55Hz resonant frequencies – Amplify neural benefits23Hz binaural entrainment – Creates cross-hemispheric effects for mental acuityWhile traditional treatments focus on physical symptoms, this track targets neurological dimensions of cognitive dysfunction. Research shows 40Hz gamma frequency promotes neural plasticity and reduces inflammation, with MIT studies demonstrating 50% reductions in inflammatory markers and improved memory in chemotherapy models.Applications:Post-Chemotherapy: Support neural recoveryChronic Fatigue & Fibromyalgia: Reduce mental fatigueLong COVID: Address persistent cognitive challengesProfessional Focus: Enhance performance during demanding tasksAcademic Settings: Improve concentration (22% better retention with gamma frequencies)Morning Clarity: Overcome sleep inertia fasterStudies show participants exposed to similar frequencies experienced 40% lower cortisol levels and 75% better sleep quality, creating a foundation for enhanced cognition.The composition guides brainwaves from scattered to synchronized, working with your brain's natural neuroplasticity to establish clearer neural pathways.Recommended Use: Listen with quality headphones for 15-20 minutes before tasks requiring mental clarity or daily for chronic conditions.Experience the power of neuroscience with Brain Fog Breakthrough and rediscover mental clarity.Send us a textSupport the show

Subscriber-only episodeBrain Fog Breakthrough is a revolutionary audio experience engineered to clear mental haze and restore cognitive clarity. This soundscape combines calibrated frequencies to address brain fog from chronic illness, chemotherapy, fibromyalgia, and Long COVID.The track features a powerful frequency architecture:40Hz gamma stimulation – MIT research shows reduced neuroinflammation and enhanced cognition32Hz and 55Hz resonant frequencies – Amplify neural benefits23Hz binaural entrainment – Creates cross-hemispheric effects for mental acuityWhile traditional treatments focus on physical symptoms, this track targets neurological dimensions of cognitive dysfunction. Research shows 40Hz gamma frequency promotes neural plasticity and reduces inflammation, with MIT studies demonstrating 50% reductions in inflammatory markers and improved memory in chemotherapy models.Applications:Post-Chemotherapy: Support neural recoveryChronic Fatigue & Fibromyalgia: Reduce mental fatigueLong COVID: Address persistent cognitive challengesProfessional Focus: Enhance performance during demanding tasksAcademic Settings: Improve concentration (22% better retention with gamma frequencies)Morning Clarity: Overcome sleep inertia fasterStudies show participants exposed to similar frequencies experienced 40% lower cortisol levels and 75% better sleep quality, creating a foundation for enhanced cognition.The composition guides brainwaves from scattered to synchronized, working with your brain's natural neuroplasticity to establish clearer neural pathways.Recommended Use: Listen with quality headphones for 15-20 minutes before tasks requiring mental clarity or daily for chronic conditions.Experience the power of neuroscience with Brain Fog Breakthrough and rediscover mental clarity.Send us a text

What if your gut held the key to a sharper mind, better mood, and fewer hot flashes?In this episode, Amy explores the powerful gut-brain connection and how your microbiome could be influencing everything from your memory to your menopausal symptoms. You'll discover why your gut is more than just a digestion machine—and what you can do to nourish it and your brain.What to Listen For [00:01:00] What is the gut-brain axis? – Understand how your gut and brain talk to each other constantly.[00:02:00] Vagus nerve explained – Why it's the “superhighway” between your brain and your belly.[00:03:00] How deep breathing can soothe your gut and brain – Simple strategies for daily calm.[00:04:00] Why 70-80% of your immune system lives in your gut – And how that impacts your brain health.[00:05:00] Gut bacteria make serotonin – The “happy chemical” mostly comes from your gut, not your brain.[00:06:00] The role of butyrate and SCFAs – Why these gut-made compounds are critical for brain protection.[00:08:00] Dr. Perlmutter vs. Dr. B: Two different dietary approaches to brain health – Low-carb vs. fiber-rich.[00:10:00] Why variety in plant foods matters – How 30+ plant types a week can transform your microbiome.[00:13:00] Is Zoe testing worth it? – Personalized gut and glucose testing may help you figure out what actually works for your body.[00:16:00] Understanding the 3 stages of Alzheimer's – Amy shares insights from Dr. Rudy Tanzi and the critical role of inflammation.The gut-brain connection is more than just a trendy topic—it's a vital component in preventing Alzheimer's and improving menopause symptoms like brain fog and mood swings. By nourishing your gut, you're also feeding your brain. Whether you lean more toward a ketogenic or plant-based diet, the key is reducing inflammation and finding what works best for you.Be sure to tune in, subscribe to the podcast, and explore your own personalized path to brain health.RESOURCES: Book a FREE Discovery Call with Amy Lang Order Amy's book Thoughts Are Habits Too: Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating. Follow Amy on Instagram @habitwhisperer

On this week's episode of the Real Health Co. Podcast, Dr. Barrett starts a series on neuroinflammation and how to combat it before it leads to chronic conditions. All of this and more on the Real Health Co. Podcast!

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/DWJ865. CME credit will be available until April 2, 2026.BTK Inhibition as an MS Treatment Strategy: Targeting Smoldering Neuroinflammation In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Sanofi.Disclosure information is available at the beginning of the video presentation.

This episode is for every woman who has watched a loved one battle Alzheimer's and wondered, "Is there anything I can do to prevent this?" The answer is yes.In part three of our four-part series on Alzheimer's prevention, we explore the latest pharmaceutical breakthroughs, the three-phase model of Alzheimer's progression, and why early intervention is everything.Tune in to discover what treatments are available, what's in the research pipeline, and how to evaluate options for yourself or a loved one.What to Listen For:[02:00] – The difference between treating Alzheimer's symptoms vs. modifying the disease itself[04:30] – The 3-phase model of Alzheimer's progression and why it matters for treatment[07:00] – The crucial difference between early-onset and late-onset Alzheimer's[10:45] – Dr. Rudy Tanzi's “sink metaphor” for how Alzheimer's develops in the brain[13:00] – The first-ever fully FDA-approved drugs to slow cognitive decline[15:30] – Who qualifies for these new Alzheimer's drugs—and who doesn't[17:00] – The serious risks and side effects of monoclonal antibody treatments[20:15] – Why these drugs only work in the early stages of Alzheimer's[22:00] – The staggering cost of new treatments and what insurance may (or may not) cover[25:00] – The future of Alzheimer's treatment: What's in the research pipeline right nowEarly is everything. This episode has covered the latest in Alzheimer's treatments, but the most important takeaway is that early intervention gives you the most options. Whether through lifestyle changes, early screenings, or new pharmaceutical breakthroughs, there are steps you can take today to protect your brain health.If this episode resonated with you, be sure to subscribe to Happy and Healthy with Amy Lang, and check out the links below for more resources!From The EpisodeEpisode 274: The Latest Alzheimer's Treatments (2025 Update)RESOURCES: Book a FREE Discovery Call with Amy Lang Order Amy's book Thoughts Are Habits Too: Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating. Follow Amy on Instagram @habitwhisperer

Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025 From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection. Hosts: Cindy Leifer and Brianne Barker Guest: Amanda Brown Society for Leukocyte Biology Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content in this podcast should not be construed as medical advice.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

Story at-a-glance Gut bacteria called Morganella morganii produce unusual fats that contain diethanolamine (DEA), an environmental micropollutant; the fats trigger inflammation that contribute to major depressive disorder The gut-brain axis operates bidirectionally — gut dysbiosis causes systemic inflammation that affects your brain while brain inflammation disrupts gut health Disruptions in gut bacteria lead to increased intestinal permeability, or "leaky gut," which allows harmful substances to enter your bloodstream and trigger systemic inflammation Neuroinflammation shifts tryptophan metabolism toward the kynurenine pathway, which produces substances that contribute to glutamate excitotoxicity, in turn damaging brain cells and contributing to depression Restoring gut health requires a comprehensive approach, including eliminating seed oils, avoiding endocrine disruptors, optimizing carbohydrate intake and carefully introducing beneficial bacteria like Akkermansia muciniphila

ReferencesFront. Genet 2015. 11 March Sec. Cancer Genetics . Volume 6 -Nature Reviews Genetics 2019. volume 20:657–674.Journal of Neurochemistry. 2019.151, Issue: 6:676-688Hypertension. 2018. Volume 72, Number 3Journal of Neuroinflammation 2020. 17,Article number: 15 Tartini, G. 1739-1741. Various Violin Concertihttps://open.spotify.com/album/3l2hknOjPdgD3WNxqPoGrF?si=bOmGO0nbRtWpfMJ2qtUtawLennon/McCartney 1966. "For No One" on Revolver (lp)https://open.spotify.com/track/1kDkaFlmkdEZiVUogaP9OZ?si=82292716f8f642eb

ReferencesJ of Neurochemistry. 2019. 151, Issue6 December: 676-688Journal of Neuroinflammation. 2020. volume 17,Article number: 15Guerra, DJ.2025. Nascent Lectures :Neuroimmune Diaventome.Nash,J.1972. "I Can See Clearly Now"https://open.spotify.com/track/30SCXVFyQGOFMdKnbgJS18?si=1ff0a57c16e94956Pinder, M. 1967 "Dawn is a Feeling" on DOFP(lp) Moody Blueshttps://open.spotify.com/track/5ukhn8xpLGRoPPMxbMuDOu?si=0ec04906ebd94bbcSeeger&Davies.1958."Bells of Rhymmy" Byrds https://open.spotify.com/track/1mpv6hIbfG75txI9zJGcf4?si=832538f153134d02Mozart. WA. 1791. Requiem Mass in D minor. K.626Performed by the Academy of St Martin of the Fields w/ Neville Mariner conductinghttps://open.spotify.com/album/2mAq4V9WfnKBIMmKGLS653?si=PJ3mysXATBSti1vfSPSP3A

In this episode of the Unreasonable Health Podcast, Regan Archibald dives into cutting-edge strategies for cognitive enhancement, focusing on neuroinflammation, gut health, and brain optimization. He explores the role of Peptides like C-Max, Cerebrolysin, and LL-37, as well as innovative treatments such as umbilical cord plasma and intranasal NAD. Regan also discusses the impact of mold exposure, heavy metals, and gut dysbiosis on brain function while sharing actionable tips for improving memory, focus, and mental clarity. Tune in to discover powerful tools to upgrade your brain health and performance!

In a groundbreaking dialogue, I sat down with Dr. Matt Bernstein, a veteran psychiatrist and the CEO of Accord, to explore how metabolic health impacts mental well-being. This illuminating conversation delves into the innovative field of metabolic psychiatry, revealing how metabolic interventions offer a new frontier for treating mental health disorders. What You'll Learn: • Understanding Metabolic Psychiatry: Dr. Matt Bernstein introduces the concept of Metabolic Psychiatry, emphasising how the brain's energy consumption is pivotal to mental health. We dive into how psychiatric conditions can stem from compromised metabolic health, transforming our approach to treatment. • Training for Psychiatry: Dr. Bernstein takes us through his journey to becoming a psychiatrist, highlighting gaps in nutrition education throughout his extensive medical training. • Metabolic Health and Psychiatry: We delve into how metabolic health is crucial for brain function. Dr. Bernstein discusses the energy needs of the brain and how metabolic strategies can serve as powerful interventions for mental conditions. Key Takeaways: • Metabolic Health as a Mental Health Cornerstone: Dr. Bernstein advocates for a foundational approach, building mental health treatments around metabolism. • The Critical Role of Lifestyle: Emphasising the influence of exercise, diet, and light exposure, Dr. Bernstein highlights the potential of lifestyle modifications to transform mental health care. • Pioneering Research and Future Directions: Dr. Bernstein is optimistic about ongoing research that promises to further validate and explain the efficacy of metabolic mental health interventions. However, concerns loom about mainstream psychiatry's willingness to adopt such approaches, reminiscent of challenges faced in epilepsy treatments. Resources: Explore Accord MH to learn more about their innovative approach and services in metabolic psychiatry. Connect with Dr. Matt Bernstein through LinkedIn to follow his journey and contributions to the field of mental health. Support the Conversation: If you found this discussion insightful, subscribe, rate, and leave a review on your preferred podcast platform to help us continue bringing vital conversations to light. Share this post with someone who might benefit from understanding the connections between metabolic and mental health—knowledge is powerful, and this could spark a significant change in someone's life. 00:40 Journey to Becoming a Psychiatrist02:43 Metabolic Psychiatry Explained03:32 Historical Context of Metabolic Treatments03:52 Ketogenic Diet and Epilepsy08:45 Challenges in Psychiatric Training14:15 Personal Story: Son's Mental Health Journey17:19 Rethinking Psychiatric Diagnoses21:40 Metabolic Treatments for Mental Health24:01 Human Evolution and Modern Health Challenges29:43 Role of Ketogenic Diet in Mental Health35:50 Ketogenic Diets and Autophagy35:58 Reducing Oxidative Stress36:43 Impact of Simple Carbohydrates37:26 Neuroinflammation and Mental Health38:19 Ketogenic Diet and Neurotransmitters42:00 BDNF and Brain Health44:39 Microbiome and Gut-Brain Axis50:01 Hormetic Polyphenols53:23 Personalised Nutrition and Gut Health54:50 Mitochondria and Metabolic Health57:47 Accord's Comprehensive Mental Health Program01:01:10 Future of Mental Health InterventionsSee omnystudio.com/listener for privacy information.

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you'd like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today's episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger's traits through neuroplasticity and mitochondrial upgrades. There's even some great advice for all the parents out there! What You'll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave's personal take • How mitochondria impact brain power, mood, and aging—and how to fix them today! • The shocking reason some people can't process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Upgrade Collective Membership: https://www.ourupgradecollective.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger's Syndrome and Neuroinflammation • 28:53 – Understanding Asperger's and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Unreasonable Health Podcast, Cade Archibald kicks off The Ageless Brain five-part series, diving into the science of neuroinflammation, cognitive decline, and brain regeneration.He explores the role of peptides like Semax and Selank in reducing inflammation and enhancing neuroplasticity, alongside nootropics and lifestyle interventions that support brain health. Cade also introduces the NeuroCatch test, a cutting-edge tool for assessing cognitive function, and challenges listeners to engage in activities that boost neuroplasticity. Tune in to discover how to optimize your brain for longevity and peak performance!To optimize your brain, check us out! https://acueastwest.com/

The Endocannabinoid System plays a crucial role in regulating cardiovascular, neurological, and immune functions through CB1 and CB2 receptors. • CB1 Activation: Associated with oxidative stress, inflammation, and increased cardiovascular risks such as myocardial infarction (MI), arrhythmias, and heart failure. • CB2 Activation: Primarily found in immune cells and linked to anti-inflammatory and protective cardiovascular effects. • Cannabis Use: High THC content or synthetic cannabinoids (e.g., Spice, K2) significantly increases the risk of cardiovascular diseases and psychiatric disorders. • Cannabis Use Disorder (CUD): Characterized by compulsive use despite adverse consequences, often co-occurring with depression, PTSD, and anxiety. • Potential Therapeutic Targets: CB1 antagonists (e.g., Genistein) and CB2 agonists are being explored for their ability to reduce inflammation and vascular damage while minimizing psychiatric side effects.   Future research is needed to clarify long-term cardiovascular effects, optimize cannabinoid therapies, and inform public health policies.

In today's episode of The Root Cause Medicine Podcast, we shed light on adult ADHD, stress-success cycle, burnout, anxiety, and insomnia and how they can all be addressed using a root-cause approach with Dr. Romie Mushtaq. You'll hear us discuss: How stress and anxiety impact adult-onset ADHD The "busy brain" and how it relates to anxiety, attention issues, and insomnia The role of chronic stress in neuroinflammation and ADHD How to manage ADHD symptoms through diet "The Busy Brain Cure" book Dr. Romie is an experienced neurologist and the author of "The Busy Brain Cure." With over 20 years in the field, she also serves as the Chief Wellness Officer at Evolution Hospitality and is the CEO and Founder of brainSHIFT Institute. Dr. Romie combines her extensive experience in neurology, integrative medicine, and mindfulness to offer impactful programs and drive cultural transformation. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Are brain fog, fatigue, and mental exhaustion holding you back?  These symptoms aren't just stress-related or signs of aging. They're often caused by hidden brain inflammation! In this episode, my guest, Dr. Datis Kharrazian, and I discuss neuroinflammation – What it is, what causes it, and how it affects brain function, mood, and overall health. You'll discover how factors like stress, diet, gut health, and past head injuries contribute to brain inflammation and what you can do to reduce it. You'll learn practical lifestyle changes, nutrition tips, and brain-boosting strategies to improve focus, energy, and mental clarity. You'll hear more on: How brain inflammation starts—and why it's often caused by everyday factors like stress, diet, or past injuries What you can do to calm inflammation naturally, including dietary changes, supplements, and specific lifestyle shifts Why understanding your triggers —from food sensitivities to emotional stress — is the key to protecting your brain from long-term damage How to optimize your brain health using tools like intermittent fasting, anti-inflammatory diets, and proper sleep routines  Whether you've experienced brain fog, recovering from an injury, or just want to preserve your brain function for the future, this episode will give you the tools and knowledge to take control of your brain health!   For more information and show notes, please visit our website: https://biologyoftrauma.com/biology-of-trauma-podcast/

In this episode of the Flex Diet Podcast, I'm recording from sunny Mexico and sitting down with James LaValle, a powerhouse in metabolism and performance health. We dive deep into liposomal delivery, blood work, magnesium benefits, key dietary supplements, and why balancing your sympathetic and parasympathetic nervous systems is crucial for optimal performance.James shares his journey from writing Cracking the Metabolic Code to his latest research and innovations, including magnesium, probiotics, and phospholipids—and how they fit into a performance-driven approach to health. Whether you're an athlete, coach, or just someone looking to level up your well-being, this episode is packed with practical takeaways.Plus, I share my personal supplement recommendations and give you a sneak peek at upcoming product reviews. Tune in now!Sponsors:Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%LMNT electrolyte drink mix: miketnelsonlmnt.comDr. Mike's Fitness Insider Newsletter: Sign up for free at https://miketnelson.com/.Triphasic 2 book now available!Go to https://triphasic2.com/Episode Chapters:02:56 James LaValle's Background and Philosophy06:13 The Importance of Nutrition and Recovery12:11 Balancing Sympathetic and Parasympathetic Systems18:52 The Role of Trace Minerals and Gut Health30:54 Neuroinflammation and Athletic Performance37:35 Understanding Carbohydrate Dependency and Metabolic Stress38:34 The Role of Supplements in Managing Metabolic Health41:26 The Importance of Personalized Nutrition and Supplementation42:28 Common Misconceptions and Realistic Expectations of Supplements43:00 The Fundamentals of Healthy Living: Eat, Hydrate, Sleep52:11 Magnesium and Its Crucial Role in Exercise and Health58:06 Innovations in Supplement Delivery: Liposomal Formulations01:04:32 Final Thoughts and Where to Find More Information Flex Diet Podcast Episodes You May Enjoy: Episode 251: The Role of Microbiome in Elevating Exercise and Dietary Outcomes with Dr Sara Campbell Episode 222: Expert Insights on nutrition, supplements, and training with Registered Dietician Sean CaseyConnect with Jim LaValle:Instagram: https://www.instagram.com/therealjimlavalle/Website: https://www.jimlavalle.com/Get In Touch with Dr Mike:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Dr. Justin Abbatemarco and Dr. Josep Dalmau discuss GAD-antibody disorders, providing updates on the diagnosis and treatment of these GAD65-related diseases. Show references: https://www.neurology.org/doi/10.1212/NXI.0000000000200363

Dr. Justin Abbatemarco and Dr. Josep Dalmau discuss the evolution of terminology in paraneoplastic disorders and the irruption of immune checkpoint inhibitors. Show references: https://www.neurology.org/doi/10.1212/NXI.0000000000200363 

Almost 2400 years ago, Hippocrates said "All disease begins in the gut"; and he was right. With modern scientific methods and studies to prove it, we can see exactly how and why all dieases begin in your gut, and what you can do to stop them. 93% od the leading causes of death are connected to your gut, and this episode is going to explain why that it, how it happens and to give you the tools you need to not only protect yourself and your loved ones, but even to reverse almost any diease.   TOPICS DISCUSSED: Reversing 93% of the leading causes of death The machanisms of how all diease begins in your gut How endotoxins (gut toxins) circulate around your body What they do to your organ systems and your body How to heal and seal your gut Reverse chronic inflammatory diseases How to heal from almost anything   Leave us a Review: https://www.reversablepod.com/review   Need help with your gut? Click the link, or visit gutsolution.ca for help: Get help now   Supplements: Get 15% off Practitioner Grade Supplements (forever) by creating an account   Contact us: reversablepod.com/tips    SOCIAL MEDIA: Instagram  Facebook  YouTube     STUDIES FOR REFERENCE: 1. LPS and Liver Disease: ·       Key Study: Lipopolysaccharides promote hepatic steatosis by activating the TLR4-NF-κB pathway in hepatocytes (Cai et al., 2012, Hepatology). Link: https://pubmed.ncbi.nlm.nih.gov/22025365/ 2. LPS and Kidney Disease: ·       Key Study: Role of lipopolysaccharide in the pathogenesis of kidney injury in sepsis (Matsushita et al., 2021, Nephrology). Link: https://pubmed.ncbi.nlm.nih.gov/33460487/ 3. LPS and Diabetes: ·       Key Study: Gut-derived endotoxin and metabolic inflammation in type 2 diabetes (Cani et al., 2007, Diabetologia). Link: https://pubmed.ncbi.nlm.nih.gov/17471239/ 4. LPS and Cancer: ·       Key Study: Gut microbiota-mediated inflammation in obesity: A link with gastrointestinal cancer (Cani et al., 2018, Nature Reviews Gastroenterology & Hepatology). Link: https://pubmed.ncbi.nlm.nih.gov/29348450/ 5. LPS and Cerebrovascular Disease: ·       Key Study: LPS-induced systemic inflammation exacerbates brain damage in ischemic stroke (Chen et al., 2016, Stroke). Link: https://pubmed.ncbi.nlm.nih.gov/26846899/ 6. LPS and Parkinson's Disease: ·       Key Study: Lipopolysaccharide induces neuroinflammation and dopaminergic neuron loss in Parkinson's disease models (Qin et al., 2007, Journal of Neuroscience). Link: https://pubmed.ncbi.nlm.nih.gov/17360907/ 7. LPS and Hypertension: ·       Key Study: Role of gut-derived endotoxemia in systemic inflammation and hypertension (Tang et al., 2017, Hypertension). Link: https://pubmed.ncbi.nlm.nih.gov/28209750/ 8. LPS and Colon/Gut Diseases: ·       Key Study: Lipopolysaccharides promote intestinal inflammation by disrupting the epithelial barrier (Schmidt et al., 2015, Gut). Link: https://pubmed.ncbi.nlm.nih.gov/25691570/ 9. Studies Supporting LPS's Role in Alzheimer's: ·       Study 1: Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain (Zhao et al., 2017, Frontiers in Immunology). Link: https://pubmed.ncbi.nlm.nih.gov/28928740/ ·       Study 2: Lipopolysaccharides cause neuronal death and cognitive decline (Molecules, 2022). Link: https://pubmed.ncbi.nlm.nih.gov/35011994/ ·       Study 3: Neuroinflammation and Alzheimer's disease: Mechanisms of action (Nature Neuroscience, 2019). Link: https://pubmed.ncbi.nlm.nih.gov/30842661/

Dr. Justin Abbatemarco talks with Dr. Josep Dalmau about the evolution of Neurology: Neuroimmunology & Neuroinflammation over the past decade, and how it has emerged as a leading journal in clinical and translational neuroimmunology. Read the related article in Neurology: Neuroimmunology & Neuroinflammation. Disclosures can be found at Neurology.org.