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Latest episodes from Genetics (Video)

CARTA: Imagining the Future of Anthropogeny with Evan Eichler and Daniel Geschwind

Play Episode Listen Later Feb 22, 2023 49:42


Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where future efforts should be focused and what type of novel collaborations are most promising to improve our understanding of the human phenomenon. Evan Eichler talks about the discovery and resolution of genetic variation which is critical to understanding disease and evolution. The data suggests that large-scale genome structural variation continues to play a crucial role in the evolution of the human species.Daniel Geschwind discusses human cognition and how human brain evolution is particularly susceptible to disruption of neuropsychiatric disorders such as schizophrenia and autism spectrum disorder (ASD). Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38630]

CARTA: Imagining the Future of Anthropogeny with Pascal Gagneux Robert Kluender Anne Stone

Play Episode Listen Later Feb 20, 2023 51:18


Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Pascal Gagneux offers a zoological view of the human cultural animal. Robert Kluender talks about the evolution of language structure and the future of linguistics. Anne Stone discusses ancient DNA research and the surprising insights into human evolutionary history. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38633]

CARTA: Imagining the Future of Anthropogeny with Terry Sejnowski and Sarah Tishkoff

Play Episode Listen Later Feb 10, 2023 47:58


Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Prostate Cancer Genetics and Genomics - Prostate Cancer Patient Conference 2022

Play Episode Listen Later Jan 13, 2023 19:09


As part of the 2022 Prostate Cancer Patient Conference, Dr. Jonathan Chou discusses the role of genetics and genomics in prostate cancer. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Education] [Show ID: 38560]

CARTA: Imagining the Future of Anthropogeny - African Genomic Analyses Shed Light on Human Evolutionary History with Sarah Tishkoff

Play Episode Listen Later Dec 21, 2022 25:26


Africa is thought to be the ancestral homeland of all modern human populations within the past 300,000 years. It is also a region of tremendous cultural, linguistic, climatic, and genetic diversity. Despite the important role that African populations have played in human history, they remain one of the most underrepresented groups in human genomics studies. A comprehensive knowledge of patterns of variation in African genomes is critical for a deeper understanding of human genomic diversity, the identification of functionally important genetic variation, the genetic basis of adaptation to diverse environments and diets, and the origins of modern humans. We have characterized genomic variation in thousands of ethnically and geographically diverse Africans in order to reconstruct human population history and local adaptation to variable environments and have identified candidate loci that play a role in alcohol metabolism and skin color. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38304]

CARTA: Imagining the Future of Anthropogeny - Ancient DNA and Anthropogeny with Anne Stone

Play Episode Listen Later Dec 17, 2022 15:22


The first Neandertal DNA was recovered 25 years ago, and since then, ancient DNA has provided many surprising insights into human evolutionary history. Among these are the discoveries of the multiple admixture events among late Pleistocene humans and the remnants of archaic DNA in our own genomes. How does ancient DNA research contribute to the future of anthropogeny? In this talk, I will reflect on the findings of last quarter century of ancient DNA research about archaic humans and their environment as well as examine potential questions that the next quarter century might answer. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38303]

CARTA: Imagining the Future of Anthropogeny - Genome Structure Variation and the Evolution of Human Specific Genes with Evan Eichler

Play Episode Listen Later Dec 10, 2022 26:04


The discovery and resolution of genetic variation is critical to understanding disease and evolution. Our most recent work sequences diverse human and nonhuman primate genomes using both ultra-long and high-fidelity long-read sequencing technologies. Advances in this area have made possible the first telomere-to-telomere assemblies of the human genome and much more complete chimp, gorilla and orangutan genomes providing new biological insights into regions typically excluded from human genetic and comparative studies. We have discovered mega basepairs of duplicated sequence and/or rapidly evolving sequence present in humans that are absent from other non-human primates. These changes have predisposed our species to recurrent rearrangements associated with disease but also have led to the emergence of new genes important in the expansion of the human frontal cortex of the brain. Our data suggest that large-scale genome structural variation has played and continues to play a crucial role in the evolution of the human species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38297]

Can Big (Microbiome) Data Save the World? – Using AI and Microbiome Data to Predict Health Outcomes

Play Episode Listen Later Jul 8, 2022 58:24


Our bodies are dynamic ecosystems housing trillions of microbes that, while invisible to the naked eye, play a critical role in shaping human health. Scientists are just beginning to understand the superpowers the microbiome holds. In this program Marina Sirota, Ph.D., explains how to use artificial intelligence to study the microbiome and better understand health and disease across the lifespan. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38130]

CARTA - Humans: The Planet-Altering Apes - Loss of Species Loss of Genetic Variation and the Future of Earth's Biota with Oliver Ryder

Play Episode Listen Later Jun 18, 2022 18:00


We are experiencing an accelerated rate of loss of species due to human activities. This anthropogenic phenomenon extends beyond extinction. It encompasses an expanded loss of biodiversity as the genetic diversity of species diminish, reducing gene pools to “gene puddles.” We know details of species extinctions events from the fossil record, historical record, and from ancient DNA studies, and that historical processes shape extinction risk. Habitat loss and changing eco-environmental conditions, competition, and other factors produce genomic impacts, also influencing extinction risk. The legacy of past events impacts resiliency of species in the current environment in interpretable ways. Demographic trajectories reveal vulnerability to extinction. Remarkable advances in genomics technologies portend a deeper understanding of the evolution of life and the vulnerability of extant species to changes now taking place through human agency. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37906]

Sea Urchins and Sea Slugs

Play Episode Listen Later Jun 3, 2022 51:24


Amazing new technologies in developmental biology and genetics research are allowing scientists to begin to answer long standing questions such as – how does a single fertilized egg cell transform into a complex animal? Why does the embryo of a marine organism like a sea slug develop differently from that of a sea urchin? Join Scripps Developmental Biologist Deirdre Lyons as she describes how she and her colleagues are pushing the limits of our knowledge to understand these intriguing questions and the long history and diversity of life on our planet. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Science] [Show ID: 37915]

CARTA: Ancient DNA and Human Evolution – Brenna Henn: The Origins of Modern Humans in Africa

Play Episode Listen Later Mar 30, 2022 19:51


Brenna Henn (Stony Brook Univ) explores patterns of genetic diversity across Africa and models for modern human origins in this talk. She discusses whether genetic data is concordant with archaeological data and suggests directions for future research. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 30979]

Epithelial Stem Cells and Combined Cell and Gene Therapy - Breaking News in Stem Cells

Play Episode Listen Later Mar 5, 2022 71:06


Michele De Luca, MD, shares his research in gene therapy for epidermolysis bullosa and cell therapy for ocular burns. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37671]

Evolution of Genome Instability in Cancer with Don Cleveland - Sanford Stem Cell Symposium

Play Episode Listen Later Feb 19, 2022 27:29


Don Cleveland, PhD, shares new research on the role of chromothripsis, targeting cancers driven by ecDNA and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37586]

Genomics - Sanford Stem Cell Symposium

Play Episode Listen Later Feb 16, 2022 72:43


Dan Kaufman, MD, PhD, David Traver, PhD, Gene Yeo, PhD, MBA, discuss the impact of genomics in relation to stell cell research including potential therapeutics for MDS and the role of the somite in hematopoietic stem cell fate. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37561]

RNA Binding Proteins: A Splicing Story in IPSC Models of MDS with Gene Yeo - Sanford Stem Cell Symposium

Play Episode Listen Later Feb 14, 2022 26:49


There are at least 2,500 proteins that bind RNA. Gene Yeo, PhD, MBA, explains how his lab studies these RNA binding proteins and their impact on human health. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37589]

Genetics of Autism with Jonathan Sebat PhD

Play Episode Listen Later Dec 11, 2021 29:26


Jonathan Sebat, PhD shares current research on how combinations of rare gene mutations and complex common variant risk factors contribute to autism. Series: "Autism Awareness Programs" [Health and Medicine] [Science] [Show ID: 37658]

CRISPaper: Understanding CRISPR Gene-Editing through Art

Play Episode Listen Later Sep 4, 2021 16:57


To Sheng-Ying Pao, the power of reframing CRISPR lies in what is absolutely ordinary: paper. In CRISPaper, Pao revisited a cultural past in the ancient art of papermaking. In ancient China, wild rice was used to make paper. Pao took rice stalks from plants edited with CRISPR and ground the fibers into pulp. She then poured the pulp over a mesh screen. Every time she dipped the screen into water, the plant fibers would lift and resettle on top of the mesh, eventually making paper. Through the genome-edited rice plant, an ancient practice was juxtaposed with cutting-edge technology. Series: "UC Berkeley News" [Science] [Arts and Music] [Show ID: 37388]

UCSF Berkeley UCLA to Launch Sickle Cell Trial Using CRISPR

Play Episode Listen Later Aug 20, 2021 4:36


UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

CARTA: The Evolution of Human Physical Activity - Herman Pontzer Grazyna Jasienska Ellen Breen

Play Episode Listen Later Jul 8, 2021 59:07


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Herman Pontzer explores the evolution of metabolism, Grazyna Jasienska discusses different effects of activity on women's reproductive health and Ellen Breen explores an evolutionary pathway for high endurance activity. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37187]

CARTA: The Evolution of Human Physical Activity - Jandy Hanna -The Rise and Fall of Climbing in Human Evolution

Play Episode Listen Later Jul 2, 2021 16:37


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Jandy Hanna explores climbing in human evolution. Most primates live and move in the trees, but humans have evolved to move bipedally on the ground. Primates' arboreal life-style has long been thought to have allowed the evolution of human beings' unusual form of movement. We know much about how horizontal movement on branches differs in primates relative to most other mammals. But only recently have we begun to learn about how climbing is accomplished by non-human primates, and how such movement may have permitted early human ancestors to move upright. Key findings regarding the biomechanics of climbing, and what these data may mean for understanding human movement and exercise, are discussed. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36948]

CARTA: The Evolution of Human Physical Activity - Herman Pontzer - The Evolution of Human Metabolism  

Play Episode Listen Later Jun 26, 2021 22:53


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Herman Pontzer explores the evolution of human metabolism and its role in our evolution and health. From an evolutionary perspective, life is a game of turning energy into offspring. The strategies that species use to acquire energy, in the form of food, and allocate energy to the essential tasks of growth, maintenance, movement, and reproduction, are incredibly diverse and reflect the ecological pressures and opportunities encountered. There is a deep evolutionary history of the human metabolic strategy and our divergence from other apes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36951]

CARTA: The Evolution of Human Physical Activity - Ellen Breen - A Human Genetic Mechanism for Endurance Running

Play Episode Listen Later Jun 23, 2021 18:48


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Ellen Breen explores an evolutionary pathway for high endurance activity. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36945]

CARTA: The Evolution of Human Physical Activity - Yana Kamberov - Genetic Drivers of Human Thermoregulatory Skin Traits

Play Episode Listen Later Jun 21, 2021 24:44


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Yana Kamberov explores how sweating evolved and what it means for Homo sapiens. Humans use sweating as the primary mechanism to dump body heat. Humans' ability to effectively harness sweating as a thermoregulatory mechanism is a product of the evolution of a massively increased sweat gland density and a drastic reduction in the size of body hair. Advances have been made in identifying the genetic basis for how these unique and essential adaptations of human physiology evolved. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36949]

CARTA: The Evolution of Human Physical Activity - Tatum Simonson - Human Adaptation to High Altitudes and Aquatic Environments

Play Episode Listen Later Jun 19, 2021 18:41


Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Tatum Simonson explains adaptations to altitude and diving. Humans have persisted for hundreds of generations under challenging environmental extremes. Adaptations to such environments have been essential for survival, enabling populations to trek successfully among high mountain tops or to dive deeply into vast seas. Unique genetic signatures, resulting from thousands of years of strong selective pressures in these environments, have been discovered within the DNA of present-day populations. These findings provide important clues into evolutionary processes in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36946]

Precision Genomics and Immunotherapy: Cancer and Beyond - Exploring Ethics

Play Episode Listen Later May 31, 2021 78:26


Breakthroughs in genomics and targeted therapies are revolutionizing the practice of clinical oncology. Precision genomics and immunotherapy offer promise to improve outcomes in cancer, but doing so means we need to move beyond historical models for cancer diagnosis and treatment. Razelle Kurzrock, MD discusses insights from this rapidly changing field and addresses some of the ethical challenges that must be met if we are to transform the lives of patients with cancer. Series: "Exploring Ethics" [Health and Medicine] [Show ID: 36637]

A Closer Look at...Spinal Cord Injury

Play Episode Listen Later May 30, 2021 80:31


Mark Tuszynski, MD, PhD, Bob Yant, and Lawrence S.B. Goldstein, PhD discuss the newest research and treatments for spinal cord injury, including how neural stem cells may be leveraged to potentially regain function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37102]

CARTA: Altered States of the Human Mind: Implications for Anthropogeny: Kenneth Kidd - Alcohol Metabolism and Alcoholism

Play Episode Listen Later Apr 13, 2021 26:49


Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36671]

Gene Therapy for X-linked SCID - Stephen Gottschalk

Play Episode Listen Later Oct 19, 2020 12:34


Stephen Gottschalk, MD St. Jude Children's Research Hospital Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36350]

Stem Cell and Gene Therapy - Matthew Porteus Tippi Mackenzie Matthew Spear Stephen Gottschalk

Play Episode Listen Later Oct 19, 2020 54:43


Stem cells may play a critical role in treating genetic diseases. Hear from experts in the field. Moderated by Matthew Porteus, MD, PhD, Stanford University Tippi MacKenzie, MD, UC San Francisco: Fetal Therapy for Alpha Thalassemia Major Matthew A. Spear, MD, Poseida Therapeutics: CAR-T Cells: Poseida Therapeutics Stephen Gottschalk, MD, St. Jude Children's Research Hospital: Gene Therapy for X-linked SCID Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36351]

Towards a Cure for IPEX Syndrome: Engineered-Treg Replacement or Stem Cell Gene Editing - Rosa Bacchetta

Play Episode Listen Later Oct 12, 2020 11:44


Gene Therapy for Artemis Severe Combined Immunodeficiency (ART-SCID) - Jennifer Puck

Play Episode Listen Later Oct 10, 2020 15:44


Jennifer M Puck, MD UC San Francisco Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36329]

Hematopoietic Stem Cell Gene Therapy for Primary Immune Deficiencies - Don Kohn

Play Episode Listen Later Oct 10, 2020 13:57


Donald B. Kohn, MD UCLA Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36330]

Blood and Immune System Disorders - Crystal Mackall Alysia Vaccaro Jennifer Puck Donald Kohn Mark Walters

Play Episode Listen Later Oct 10, 2020 65:53


What impacts has stem cell research made for blood and immune system disorders? Hear the latest from experts in the field. Moderated by Crystal Mackall, MD, Stanford University Alysia Vaccaro: Patient Perspective Jennifer M Puck, MD, UC San Francisco: Gene Therapy for Artemis Severe Combined Immunodeficiency (ART-SCID) Donald B. Kohn, MD, UCLA: Hematopoietic Stem Cell Gene Therapy for Primary Immune Deficiencies Mark C. Walters, MD, UCSF Benioff Children's Hospital Oakland: Gene correction in Sickle Cell Disease Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36332]

Gene Correction in Sickle Cell Anemia - Mark Walters

Play Episode Listen Later Oct 4, 2020 13:58


Mark C. Walters, MD UCSF Benioff Children's Hospital Oakland Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36331]

Fetal Stem Cell Transplantation for Alpha Thalassemia Major - Tippi Mackenzie

Play Episode Listen Later Oct 2, 2020 15:01


CAR-T Cells: Poseida Therapeutics - Matt Spear

Play Episode Listen Later Oct 2, 2020 12:49


Matthew A. Spear, MD Poseida Therapeutics Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36349]

Individualized Patient Therapy Stem Cells and Gene Editing

Play Episode Listen Later Aug 22, 2020 8:32


Dr. Aimee Kao discusses how induced pluripotent stem cells, iPSC's, could offer ways to individualize patient therapy. Dr. Kao then looks at the history of gene editing. [Health and Medicine] [Show ID: 36270]

The Evolution of SARS-CoV-2

Play Episode Listen Later Jun 15, 2020 56:44


In this presentation from the course The Evolution of Infectious Diseases, professor of biology and infectious disease researcher Justin Meyer provides a detailed overview of the previous, current and future evolution of the SARS-CoV-2 virus. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Health and Medicine] [Science] [Show ID: 36095]

Your Genetic Privacy in the Big Data Era - Exploring Ethics

Play Episode Listen Later Nov 23, 2019 52:40


In the United States, privacy is considered a fundamental right. Yet today our activities are followed to a degree unfathomable not long ago by way of cell phones, online behaviors, and more. As genomic technologies continue to expand, another avenue now exists by which we may potentially be scrutinized: DNA sequence. Our genetic information contains our most private details, but we leave it everywhere and share the sequence closely with dozens or even hundreds of relatives. Laura Rivard, PhD, professor of biology at the University of San Diego, discusses ways in which our DNA may "escape" from our control, what can actually be done with the sequence, and whether there is cause for concern. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Science] [Show ID: 34998]

Sensory Implications of Brain Organoids with Patricia Churchland

Play Episode Listen Later Nov 8, 2019 44:45


What defines consciousness? Can it develop in a petri dish? Patricia Churchland reviews the current state of brain organoid research and shares her views on how conciseness and physical structures within the brain intersect. She also cautions the media on the tendency to "over hype" new research advances. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35247]

The Current Status of Human Brain Organoids Research with Alysson Muotri and Larry Goldstein

Play Episode Listen Later Nov 1, 2019 36:25


The study of brain organoids is leading to a better understanding of human development and potential therapies for neurological disorders. Yet when people hear the phrase "brain in a dish" it instantly brings to mind the stuff of science fiction - labs full of sentient brains thinking and plotting. Alysson Muotri explains why these organoids should not called "brains in a dish" and how they are being used to explain human processes previously inaccessible to study. While underscoring scientific value of these organoids, he also raises the question of what ethical questions demand an answer as the technology improves. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35245]

Stem Cells to the Rescue: Saving the Northern White Rhino from Extinction

Play Episode Listen Later Oct 29, 2019 39:29


There are only two Northern White Rhinos left on the planet. How can we reverse extinction to save them and use the lessons learned to help other endangered species? Marisa L. Korody, PhD of the San Diego Zoo Institute for Conservation Research shares how scientists are using the latest in stem cell technology for a genetic rescue. Series: "Women in Science" [Science] [Show ID: 35227]

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