Podcasts about translocator

On this week's podcast Ursi and Proud rant and rave. Topics include: Sven, Witch Doctor, Ember Spirit, Tinker's Translocator facet, Vengeful Spirit core, Tiny, Drow, the existence of too many support players, Helm of the Dominator/Overlord, Lifestealer, Radiance, and so much more!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.23.529740v1?rss=1 Authors: Pradhan, A. K., Neumueller, T., Klug, C., Fuchs, S., Schlegel, M., Ballmann, M., Tartler, K. J., Pianos, A., Garcia-Sanchez, M., Liere, P., Schumacher, M., Kreutzer, M., Rupprecht, R., Rammes, G. Abstract: Alzheimer's disease (AD) is characterized by the accumulation of {beta}-amyloid peptide (A{beta}). There is increasing evidence that depression may precede AD and may be an early manifestation of dementia, suggesting common mechanisms underlying both diseases. Ligands targeting the mitochondrial translocator protein (18 kDa) (TSPO), promote neurosteroidogenesis and may be neuroprotective. Moreover, TSPO is upregulated in AD. To study whether the TSPO ligand XBD173 may exert early neuroprotective effects in AD pathology we investigated the impact of XBD173 on amyloid toxicity and neuroplasticity in mouse models. We show that XBD173 (emapunil), via neurosteroid-mediated signaling via delta subunit-containing GABAA receptors, prevents the neurotoxic effect of A{beta} on long-term potentiation (CA1-LTP) in the hippocampus and prevents the loss of spines. Chronic but not acute administration of XBD173 ameliorates spatial learning deficits in transgenic AD mice with arctic mutation (ArcA{beta}) mice. The heterozygous TSPO-knockout crossed with the transgenic arctic mutation model of AD mice (het TSPOKO X ArcA{beta}) treated with XBD173 does not show this improvement in spatial learning suggesting TSPO is needed for procognitive effects of XBD173. The neuroprotective profile of XBD173 in AD pathology is further supported by a reduction in plaques and soluble A{beta} levels in the cortex, increased synthesis of neurosteroids, rescued spine density, reduction of complement protein C1q deposits, and reduced astrocytic phagocytosis of functional synapses both in the hippocampus and cortex. Our findings suggest that XBD173 may exert therapeutic effects via TSPO in a mouse model of AD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-11896.mp3?cb=1676549964.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer’s disease – PubMed Lauren H Fairley et al.Full EntryMitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease – PubMed

  This week Andres & Rob sit down with returning guest Fitzyhere to revisit the Sombra Going Deep! She’s undergone a significant amount of changes to her kit and we were able to land our interview with him so buckle up and prepare to hack in! Sombra Reference Source ANNOUNCEMENTS: GAME NIGHT: 8/31 Report! SPONSOR: Top Score Solutions Ben aka “INeedPeeling” is offering free business consulting in the eSports field. If you are aspiring to coach, starting a team, developing an app or service, trying to boost your subscriber base, or just want to work in eSports, you can visit his website at topscoresolutions.com, get him on Twitter @topscoreEsports, or join his Discord server. Ben has a Masters in Sport Management, Finance and Data Analytics as well as experience in sales, marketing, and company development. His services are free, and they will stay that way as long as demand allows it. Omnic Meta: (Homepage) Aug 21 - Support Analysis Patch 1.27 Going Deep Hero Breakdown: What is the fundamentals for Sombra or what is her job in a game Can we chat about positioning and how to use your position/presence and movement to maximize damage and pressure Let’s talk about using the new Translocator and effective use How to do we get the most out of Hacking Proper timing for EMP breakdow How Map Dependent is Sombra? Now let’s work on proper engagement and disengages. Now let’s talk synergies and match-ups. What heroes do you need to be careful of for being countered and others that you really think are great/necessary for your comp. Special Thanks to Diamond Sponsors & New Patrons: Ben K, Britmus, Chrisdaplaya, DurandaL, JanJinkle, Lisome, Mr.Marz, Neverclutch, Roger B., RickyTicky, Shazear, Terry F, Top Score Solutions, TragicZac. Omnic Lab Links: Omnic Lab is now a Twitch Affiliate! Sub now with Twitch/Amazon Prime! Twitter, Facebook, Patreon Twitch, Youtube, MERCH Discord: discord.me/omniclab Email: omniclabpodcast@gmail.com Website: http://www.omniclab.com iTunes, Google Play Music, RSS -->Full Extended Show Notes

Sombra can hack everything and everyone. In this episode we'll discuss how to effectively use her hacking ability to give you team the advantage, as well as the best way to use Translocator, her primary weapon, how to take advantage of enemies with low health, and using her EMP to it's fullest potential

Sombra can hack everything and everyone. In this episode we'll discuss how to effectively use her hacking ability to give you team the advantage, as well as the best way to use Translocator, her primary weapon, how to take advantage of enemies with low health, and using her EMP to it's fullest potential

In the Lab this week Andres & Rob sit down to talk through a lot of various topics that we think are important for all players in Overwatch. General tips, specific techniques, and even mental tips on how to better equip yourself to handle improving in the game. News & Blue Posts: Omnic Meta: (Homepage) Top Hero Mains for S6 Console Meta Oct. 3, 2017 Halloween Terror 2017 coming Oct. 10th! Overwatch Contenders Finals at the new Blizzard Arena: NA: EnVyUs vs FaZe EU: Gigantti vs Misfits Hero Tips &Tricks: Doomfist: Meteorstrike gives you a TON of shielding when you hit 2 targets so you can get a pick and make yourself extremely durable. Genji: Your dash can animation cancel through your sword strikes giving you an immense burst capability in a short amount of time. Using the right click in combination with a melee provides a huge burst of damage immediately following a swift strike dash on a target. McCree: Deadeye can be used as a quick reload which can be helpful in specific situations or to catch the enemy off guard. Pharah: If done right you will never have to touch the ground! (not always the best idea, but possible). You can jump before boosting yourself off the ground for and even higher altitude. Reaper: Your teleport can be used to dodge certain death from things like D.Va’s ult if timed right. Using all/most of your shots before using Wraith form is a good practice since it reloads your clip to full Soldier: Try to use Helix Rocket at the feet of enemies to pop them up for a brief second and make their movements more predictable for follow up shots. Sombra: Using the Translocator early and just poking and being annoying is the best thing. Never over-stay your welcome. Be sure to hack the right targets! Tracer: Angle your pulse bomb slightly downward to throw it right in front of you. Throw the bomb at the feet of people in a graviton to ensure maximum damage. Use map props to make up for your vertical mobility disadvantage. Bastion: Interweave healing in between your attacks while in ult form. If done right you will have no downtime, but a lot of extra health. Hanzo: Firing your ultimate through walls the enemy team is not expecting can be a great surprise. Your ultimate can be deflecting by Genji’s right before it explodes into the dragon, watch out! Junkrat: You can use both charges of your exploding mine to create a double jump and get to places a lot of heroes can’t. 1 Mine and any other junkrat grenade or trap is a 100% kill on 250 HP heroes or less. Using the ultimate when against low damage heroes like Winston solo you can detonate it right away and they can’t kill the tire fast enough. Mei: Hitting the wall button a second time changes the wall’s orientation between horizontal and vertical. If a target is starting to freeze you can let go of the spray fire a little earlier and continue to track the target because the spray is still a projectile applying damage & Freeze. Using the Primary fire during blizzard does increase the speed of freezing someone and adds damage. Torbjorn: The Hammer does do increased damage during ultimate, but only use when a Rein is Barriering you or DVa is matrixing and you’re out of ammo. Primary fire, while odd trajectory, is generally more powerful than the alternate shotgun round at medium range unless you can land all the shotgun rounds. Widowmaker: Fake falling can be a great way to dodge/avoid an incoming gank. Throw yourself off of your high ground (or cliff) and after a little delay grapple yourself back up (ideally on a different part of the high ground). Using the Grapple Hook on the ground is a quick way to dodge and space between an enemy for a quick flick shot. Special Thanks to Diamond Sponsors & New Patrons: (11/25) Ben W, Good Apollo, Lisome, Magic, Michael Crits, NotMuaddib, RcCrispy, RickyTicky, Sketchy Nonsense Podcast, TragicZac, & Trinium. New Patrons this week: Chrisdaplaya, Koen D. Omnic Lab Links: Twitter, Facebook, Patreon Twitch, Youtube, MERCH Discord: discord.me/omniclab Email: omniclabpodcast@gmail.com Website: http://www.omniclab.com iTunes, Google Play Music, RSS Full Extended Show Notes Rob: Twitter, Twitch, Velen's Chosen Podcast, Concept Craft Podcast Andres: Twitter, audioblender.studio, soundcloud ConBeforetheStorm: Website, Bob’s Tweet

In the Lab this week we have the release of Doomfist to live with all the crazy updates to ranked and a big surprise for us for Attackers having an advantage in Overtime! Last we want to make sure we highlight the big rollout for the reporting toxic players feature. News & Blue Posts: Omnic Meta: (Homepage) Console Meta Report S5 W8 Possible Junkrat changes to PTR (Source) PVPTwitch Thoughts Video Possible Roadhog change coming to PTR (Source) OWL Signings & Salaries (Source) OW World Cup LA Tickets on sale $14.99-$39.99 (Source) LIVE: Reporting & Penalty System Improved (Blue Post) LIVE: Attackers’ Advantage//Defender Respawn adjusted (Blue Post) Patch Notes: 1.13.02 - General Doomfist is now playable.  Lootbox Update!Credits instead of duplicates or more credits for when you do get duplicates New Highlight Options Top 5 Highlights available for 24 hrs or until the next patch Players can generate highlights 12s in the past from a button press command Adjusted Respawn timers as mentioned before. Custom Games & Browse User Interface CUSTOM RETICLES Options > Controls > Reticle > Advanced Valkia Reticle Tutorial Guide Video TIE GAMES NO LONGER INCLUDED FOR WIN PERCENTAGE CALC. Patch Notes: 1.13.02 - Heroes & Bugs D.Va Defense Matrix & Genji Deflect - New sounds & VO for eating ultimates McCree - Flashbang - Stunned targets slowed more heavily (mentioned before) Reaper - Shadow Step - Sound & VO distance reduced 50% (mentioned before) Reinhardt - Rocket Hammer - Swing Speed up 10% Zarya - Graviton Surge - Now disables mobility abilities on all affected targets Bugs: Could cause UI to incorrectly indicate enemies being hit when colliding with them. Projectilesthat could pass through shields sometimes passed through other surfaces. Sometimes losing audio during matches. Sombra took damage sometimes on using Translocator. Roadhog sometimes could hook Orisa Ult Rein’s Bloodhardt, Blackhardt, & Wujing skins now have sounds that sound like Axes! Rein’s Rocket Hammer had lots of hit registration bugs, all fixed. Lucio sometimes didn’t get full speed boost when wall-riding backwards. Torbjorn sometimes could not build/upgrade the turret. Special Thanks to Diamond Sponsors & New Patrons: Awestruct, Ben W, IceWeasel, HannibalSnowden, Lisome, Magic, Michael Crits, RcCrispy, Sketchy Nonsense Podcast, Spektr, TragicZac, Trinium, & Zampano. New Patrons this week (2 NEW): Kevin S & Chris C Omnic Lab Links: Twitter, Facebook, Patreon Discord: discord.me/omniclab Email: omniclabpodcast@gmail.com Website: http://www.omniclab.com iTunes, Google Play Music, Youtube Twitch, RSS, MERCH Full Extended Show Notes Rob: Twitter, Twitch, Hearthstone Podcast: Velen’s Chosen Andres: Twitter, audioblender.studio

Ctrl Alt WoW Episode 006 – Were you prepared January 20, 2007 Segment I.    What's Going On A.    Can I have your attention please - B.    Installing and running Burning Crusade – success C.     My train was late into Chicago, Amtrak was nice, they put us up in a hotel, but that meant I wouldn't be getting home on Monday night as I planned.  I would have had just enough time to get in line at Ebgames and pick up the 2 copies I had reserved.  So Sunday night I'm stuck in Chicago trying to figure out how to get my copies of BC.  I would be on the train for almost 24 hours once I left Chicago Monday night, so there would be no way to get it.  Could I ask my husband to go to Ebgames Monday night and stand in line?  I don't think so. No. 1.    Very very painless.   The installation took went pretty fast.  Four disks, a 163 mb patch, then a 4.3 mb patch and then that opening screen No. 2.    I started a blood elf and of course the starting area was jam packed.  But there was no lag and it was like Time Square on New Year's Eve.  People were dancing and flirting and laughing to try out all the new emotes. D.    I was able to mail items to my Burning Crusade character and invite her to the guild from a character on the non updated side. E.    I don't have an alt over 55, so no Outlands for me.  I was excited about getting my 47 Hunter Leatherworker over 300.  I went to the Tribal Leatherworker trainer in Strangethorn Vale and picked up some new recipes but it turns out to go over 300, she has to go to Outland and find a Grand Master Trainer in, yep you guessed it, Outland F.    Burning Crusade – A success in my bookSegment II.    WoW News A.    Topping the 8 million mark B.    nSegment III.    Alt Round Up – A.    Who's Doing what No. 1.    I've been mostly busy with the twins, Zee and Pril, brother and sister Blood Elves, same coloring and hair.  Zee male rogue and Pril female hunter.  They've been leveling mostly in Eversong Woods.  One thing I like to do is sometimes grab the first profession handy.  This way they can begin to make stuff and then unlearn it and learn the ones they really want.  So Pril got alchemy from that alchemist at the party at Saltheril's Haven and Zee got herbalism there as well.  So he was able to pick up some bloodthistle.  He had already gotten Jewelcrafting from the trainer in the inn in Falconwing Square in the Ruins of Silvermoon.  I got them both up to 10 and Pril got pet taming, there's a quest at Farstrider Retreat, not to be confused with Farstrider Square, which is in Silvermoon.   No. 2.    Prilfire got the guild and turned it over to Aprillian (was able to get Aprillian again on Alleria) and she designed the new tabard, an octopus representing the many alts. No. 3.    Prilfire made a couple of things, ironfeather No. 4.    Pryl in Westfall No. 5.    Illia making money – No. 6.    Sent a 3 storage alts to Silvermoon City via the Translocator in UC – Aranxcha, Miasha and Theeo (actually Theeo's a level 17 but he also had all the cooking supplies for leveling cooking) .  They were able to help better leather pants and shirts, some weapons and supplies. No. 7.    Sent Rillia my level 36 Rogue Blacksmith/Enchanter to give a couple of boosts.  Particularly speed to boots.  But it's kind of tricky with two accounts.  Rillia is on the account with Zee so she could enchant Pril's stuff, but not Zee.  Zee's stuff had to be traded to Pril, echanted by Rillia and then traded back to Zee.  Ooh and Rillia had over 30 bars of silver so she gave a bunch to Pril to give to Zee and now Zee No. 8.    So now Zee and Pril are pretty set up, nothing to special but a few enchants and nice gear and they are out questing heading towards Ghostland, a few quests in Tranquillium and then back to Silvermoon City when I decided Pril needs Ressan the Needler as a pet.  So they both went through the Translocater and out into Trisfal Glades where they picked up some quests in Brill and headed into the forest.  The first time Pril died trying to tame Ressan and Zee ran away so they wouldn't have to kill him.  Then when she came back, she tamed him the second time and now she's been hunting with them doing the Brill quests.  I've got pix on the web site http://ctrlaltwow.blogspot.com B.    Ideas/Discussion No. 1.    If you can't have two accounts, just be sure to send anything you might need enchanted to your enchanter before you equipped it if it's bind on equip No. 2.    I was able to get an alt from sunstrider Isle to Fairbreeze Village at level 1 without her coming in to contact with any mobs.  Of course a lot of this had to do with all of the activity.  So right now might be a good time to get a bank in Silvermoon city.  Also, with the translocater from UC to Silvermoon City, an undead bank might work as well. No. 3.    Create follow macro and place in the same number slot for every following character. Have the following alt complete the no. of collection quest first, that way the leading one can still identify the quest drops Segment IV.    Server Shout out A.    Alleria No. 1.    To Kokoh B.    Silverhand No. 1.    Server splitup Segment V.    In The House – Discussing what is going on in our real lives that has been affected by playing World of Warcraft A.    Lots of people taking off from work and school B.    I almost panicked when I realized my train was going to be delayed in to Chicago.  I was constantly watching the times we arrived and I had to hold back on pestering the train crew.  Then I started calculating taking the bus to New York, which would have been about a 24 hour bus ride and then catching a train from there, just to get home by Mon night. Segment VI.    Favorite Places/Things about WoW A.    Eversong Woods No. 1.    It's really pretty, I love two sides to Silvermoon City Segment VII.    Email – A.    See below. B.    Still looking for some No. 1.    Ctrlaltwow@gmail.com - email No. 2.    http://ctrlaltwow.blogspot.com - website/blog No. 3.    http://Ctrlaltwow.podcastspot.com - podcast site Segment VIII.    Closing Thoughts A.    Burning Crusade No. 1.    A couple of good reviews on iTunes No. 2.    Trying to stay focus but would like some more feedback Hi, i like the show a lot.  I have been playing WoW for about 7 months and have gotten hooked on it just like everyone else, but it had become kind of a vice for me because it eats in to my free time so much.  I was on the verge of deleting my level 60 and all of my alts and leaving the game for good.  But on the day that i was going to do it i met a level 18 warlock, named Yosie, in west fall while playing on my priest alt for the last time (or so i thought).  She sent me a random group invite and asked me if i would like to quest together, so i decided to use my 60 for one last good deed before it got deleted and got on Nidus (my 60 main).  I helped her finish her quests in west fall, since I am a fire mage this was an easy task for me (AoE FTW).  We had fun and chatted about our real lives and about WoW, it turned out that she had only been playing for 2 weeks.  In return for my good deed she gave me a guild invite to , which is the guild I am in now and its the best guild i have ever been in, and i was very grateful.  The next day we grouped again and had even more fun together, I helped her get her Sucubis quest done and had fun joking around and talking in the party chat.  Sadly Yosei deleted her character, but the fun that i had those 2 days made me realize that WoW is more then a video game its a social experiment and that i was part of a global community.  So i made a New Years resolution to keep playing WoW but in moderation, so instead of deleting my 60 i just deleted my alts.  I enjoy your podcast and i hope you don't get discouraged, your part of a global community too and you should make sure your voice is heard even if its not the loudest. Nidus - level 60 mage Silver Hand

CTRL ALT WOW  004 The Road to Burning Crusade I WHAT'S GOING ON A.    Preparing for the Burning Crusade i.Most upper level folks have been grinding I suppose but I've been gathering materials.  Level 41 Hunter Treshel is mining her heart out.  Level 10 Alliance is mining copper so she can send to my new Dranei, then she will be deleted.  I feel kind of guilty knowing she's working so hard only to be “killed” off. ii.    Took my 52 into Azshara to do Hunter Quest – Very hard and challenging solo but it was worth it.  Found the limit of riding through mobs B.    After listening to some other podcasts about World of Warcraft, I realized I needed to cover the “why I play World of Warcraft” subject.  I've touched on how I've come to play it, with some friends from Second Life, but I never really elaborated on why I love it so much. 1.    My history in gaming: a.    A little Magic the Gathering.  Mostly computer games.  Hitchhiker's Guide Text game.  Played a version of Dungeons & Dragons on a DOS computer.  Loved the quest. b.    Arcade Games Pacman in Japan, Centipede, Missile Command, Asteroid House of the Dead II – Going through the same game trying to do better.  In HOD2, I knew which monsters were coming from where and when to get ready.  It was repetitious but challenging. c.    A-Train, Sim City, Deus Ex, Marathon (the whole series)The Sims, Quake 3, TSO and the Second Life,. 2.    I love virtual worlds.  There is something very attractive about a place I can visit just by logging in on my computer.  I loved playing Marathon and Quake 3.  I played Quake 3 with a friend.  She was in NY and I was in DC and we'd set up a server and played the game from start to finish.  It was so much fun.  We both had earpieces from our cell phones and we talked to each other.  Being on my computer and interacting with another person was so much fun.  The Sims were great because there were all the other aspects of interactivities, and this led to TSO, which was fun because of the interactions with other real people.  Second Life was an awesome eyeopener because you could personalize and build.    3.    But when I tried WoW and I found it had all the elements of the games I most loved.  It had quests, like     Quake 3 and Marathon, with the grouping aspects and virtual online like TSO and SL, along with the creative aspects and personalization.  Alts brings with it the whole D&D game/Sims game iii.    Played my alliance character – 2 funny things happened both in Fargodeep Mine in Elwynn Forest 1.    I came upon a player just standing in one of the tunnels.  He was being attacked by two Kobold Tunnelers and he was going down.  I took the two mobs down and was going to keep going, Pryl was farming copper.  But then I realized some more mobs would be spawning, so I stayed nearby.  I sent him a whisper telling him to wake up.  After about 5 minutes he was back and fighting.  A few min later he whispered a thanks back to me and said he had to chase his kid.  I told him I thought as much and was glad to help. 2.    Later, as I was mining, another behind me and tried to mine the same one I was mining.  I don't mind sharing but I could tell on the mini-map there was another node just a few feet ahead into the tunnel and this person seemed to be trying to sneak in.  When I'm questing with a party, we usually take turns to get the exp, because if I hit it once and another miner hits it once, we both will get a point of exp.  But this guy almost seemed to be hitting it as I was hitting to take it from me.  I just laughed to myself and he ran ahead and got the next one after killing some mobs.  I went ahead and killed a bunch more and got another node.  Then I got a whisper that said “don't take all the copper, I need some”.  I kind of chuckled at that and said, “we all need copper, hon” and he wrote “yeah, but don't take it all.”  Now I'm perplexed and I said “so if I see some copper, I'm suppose to run by it?”  I wasn't trying to be mean, the nodes in Fargodeep respawn fairly quickly, so there was no danger of my “taking all the copper” II       WOW NEWS Check the website more often, on 1/5/07 there were Burning Crusade and the Special Edition for sale on the the website. New realms opening up with Character Transfers IV       IN THE HOUSE A. Heading to MacWorld on the Train.  Hoping Blizzard is there. V       BURNING CRUSADE A.    Bloodthistle B.    Translocator in Undercity still working. I took my 8 Troll to Silvermoon City, she spoke with Defiler Emissaries and I got the message she was neutral with the Defilers.  I don't know what she was before but I'm sure that will come in handy C.    Dranei tail VI       FAVORITE SPOTS IN WOW Azshara – Beaches to Mountains. VII    Emails please A.    CtrlAltWoW.blogspot.com B.    CtrlAltWoW@gmail.com VIII       TIPS AND HINTS Rest in Inns or major cities earns you bonus points Ctrl Alt WoW http://ctrlaltwow.blogspot.com ctrlaltwow@gmail.com

DURING photosynthetic CO2 fixation, fixed carbon is exported from the chloroplasts in the form of triose phosphate by the chloroplast phosphate translocator, which is the principal polypeptide (E29) from spinach chloroplast envelopes1. We have sequenced this nuclear-coded envelope membrane protein from both spinach and pea chloroplasts2,3. An envelope membrane protein, E30, has been identified as a possible receptor for protein import into pea chloroplasts using an anti-idiotypic antibody approach4–6; antibodies raised against purified E30 inhibited binding and import of proteins into chloroplasts7. The amino-acid sequence of E30 deduced from its complementary DNA7 turned out to be highly homologous to that of E29, assigned by us as the spinach phosphate translocator2, and was identical to the corresponding polypeptide from pea chloroplasts3. Differences in the binding properties to hydroxylapatite of £30 and the phosphate translocator suggested that E30 was not responsible for the chloroplast phosphate-transport activity but was the chloroplast import receptor7. Here we present evidence that argues against this and which identifies E30 as the chloroplast phosphate translocator.