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In this engaging episode, David Hough shared key updates following PaxMedica's recent meeting with the FDA, highlighting pivotal achievements such as: FDA discussion of PaxMedica's data from the PAX-HAT 301 Study and comprehensive nonclinical programs. PAX-HAT-301 study confirmed as positive evidence for African Sleeping Sickness treatment, expected to result in substantial time and resource savings for PaxMedica. FDA acknowledgment of PaxMedica's comprehensive nonclinical program, including safety pharmacology, ADME, and toxicology studies. Waivers granted for the thorough QT/QTc studies, affirming data relevance to the patient population. 2024 NDA submission anticipation underscores PaxMedica's commitment to neglected tropical disease treatments.
In this engaging episode, David Hough shared key updates following PaxMedica's recent meeting with the FDA, highlighting pivotal achievements such as: FDA discussion of PaxMedica's data from the PAX-HAT 301 Study and comprehensive nonclinical programs. PAX-HAT-301 study confirmed as positive evidence for African Sleeping Sickness treatment, expected to result in substantial time and resource savings for PaxMedica. FDA acknowledgment of PaxMedica's comprehensive nonclinical program, including safety pharmacology, ADME, and toxicology studies. Waivers granted for the thorough QT/QTc studies, affirming data relevance to the patient population. 2024 NDA submission anticipation underscores PaxMedica's commitment to neglected tropical disease treatments.
Riding a sidecar outfit is completely different from riding on two wheels, you could say like riding a horse of a different color. And some riders either love riding with a sidecar or simply find that it just suits their needs. Perhaps age, disability, visibility, pets, storage or stability are some of the reasons that come in to play when choosing to ride with a sidecar. And although many of us may never choose to give up two wheels, aren't you just a little bit curious as to what it would be like to ride a sidecar outfit? How would you know until you try it? To find out more we talked with renowned motorcycle safety instructor David Hough, Jay from DMC Sidecars and Lee Coltharp who is the South Central Regional Director of the United Sidecar Association. If you've enjoyed this episode please consider supporting this show by going to adventureriderradio.com/support and also check out our sponsors. Follow Adventure Rider Radio: Facebook: AdventureRiderRadio Instagram: @adventureriderradio Twitter: @ADVRiderRadio For more on this episode see the show notes at Adventure Rider Radio.
Motojournalist, author and AMA Motorcycle Hall of Famer David Hough, and Andy Goldfine, the founder of Aerostich RiderWear, Ride to Work Day, and the recipient of the 2013 AMA Dud Perkins Lifetime Achievement Award, have a decidedly practical approach to motorcycling. But like all motorcyclists, their passion for riding runs deep. Tune in to hear their stories!Support the show (https://fs4.formsite.com/AMARacing/form21/index.html)
When you walk in to a motorcycle shop the selection of riding gloves can be overwhelming. And which do you choose? What materials should you be considering? David Hough has some expert tips to help you the next time you’re looking at gloves and need to make a decision on which ones you’re going to depend on to keep your hands safe. And when your motorcycle gets stuck or falls in a way that’s difficult to pick up, you can be left standing there scratching your head, especially if you’re on your own. But, not if you have this self recovery system, called a Z-Drag.
Hitting a Road Block on the Last Leg of His Trip Spencer James Conway has a goal of circumnavigating every continent, and his last adventure has been in South America. On October 7th he posted on Facebook that he was just two weeks away from completing his trip. When ARR host, Jim, spoke to Spencer, he was stuck at the border in Venezuela, unable to cross in to Colombia. His alternative? A 7000 km detour which will add two months to the trip. http://www.spencer-conway.com/ Brrrrr….Keeping the Chill Out and the Heat In On Your Bike In the Northern Hemisphere, we’re starting to experience some chilly weather, and dedicated motorcyclists like to push the season, riding until the snow flies. Weather can be unpredictable, starting off chilly, warming up and then cooling down again, all in one day. So, being prepared for cold weather this time of year is important. Some of you might be lucky and live in year round warm climates, or maybe it’s spring for you right now and you’re aching to get out and ride, cold or not. Either way, we’ve got some great tips from author and retired instructor, David Hough, Aerostich’s founder, Andy Goldfine and we also talked to Bryan Miller and John Sullivan, the owner’s of Hippo Hands. David L Hough - Author & Instructor David is a world traveller, a certified motorcycle safety instructor and the author of several books. He’s become a regular on Adventure Rider Radio, a valued source of information when it comes to riding motorcycles, including sidecars and trikes. When it comes to riding in the cold, after 36 years of commuting to work by motorcycle in Port Angeles, Washington, who better to give some tips on keeping warm? Andy Goldfine - Aerostich Founder Aerostich are manufacturers of rider gear in the United States, and they’ve been designing and manufacturing clothing for about 34 years. Andy Goldfine has some great tips on what to wear to keep warm. www.aerostich.com Bryan Miller & John Sullivan - Hippo Hands There are gloves and then there are Hippo Hands, motorcycle hand covers designed to keep your hands warm and dry. www.hippohands.com Show Sponsors: Max BMW BestRest Products Green Chile Adventure Gear Motobriiz IMS ProductsPSSOR Music by Jason Shaw at www.audionautix.com
There are many possible causes for why your motorcycle is vibrating, and David Hough, author of Proficient Motorcycling, and Walt Fulton join Jim Martin to offer their knowledge and experience with vibration issues. David L. Hough: David has been riding motorcycles for more than 50 years. He's travelled extensively by motorcycles in North & South America, central Europe, the UK, South Africa and New Zealand. While employed at The Boeing Company in Seattle for more than 36 years, he mostly commuted to work by motorcycle. Combining his travel and commuting experience, he became a highly skilled rider and continues to share his knowledge through various magazine publications and several books, including Proficient Motorcycling. David is a certified motorcycle safety instructor and has taught motorcycle training courses. He's been an influence in the development of courses by the Motorcycle Safety Foundation and the Sidecar/Trike Education Program. An award winning author, David L. Hough was inducted in to the AMA Motorcycle Hall of Fame in 2009 in recognition of his lifetime efforts towards motorcycle safety. Walt Fulton: Owner and Head Instructor of Streetmasters Motorcycle Training Workshops in Corona, California. "A former three-time winner at Daytona and team racer for Harley-Davidson, Kawasaki and Suzuki, he was a featured rider in the documentary "On Any Sunday." He is a BMW Legends racer, a professional motorcycle accident reconstruction expert, motorcycle journalist and a private riding instructor. He has worked as an editor for Cycle Guide, Cycle World and Motorcyclist magazines and a contributor and the performance tester for Motorcycle Consumer News. He has logged over a million miles on the road and track." ~~Source: http://www.streetmasters.info/about_us/index.html Dealing with handlebar vibration? Check out our episode with Cole Townsend from Fasst Company: http://www.adventureriderradio.com/adventure-rider-radio-episodes/2017/1/19/custom-fitting-your-bike-to-your-size-motorcycle-handlebars-women-adv-riders?rq=cole%20townsend Show Sponsors: Max BMWBestRest ProductsGreen Chile Adventure GearMotobriizPSSORIMS ProductsMotobird Adventures Music by Jason Shaw at www.audionautix.com
In this first part of a two part series, we talk to David Hough about riding in high winds and Grant Johnson about rainy weather riding. Also, Chantal Simons has done long distance trips on both a Ducati Monster and a Chook Chaser? And what she's learned is that asking yourself the right questions when faced with a hurdle is what can make the difference in how your trip turns out. David Hough: Riding in High Winds David is a certified motorcycle safety instructor and has taught motorcycle training courses. He's been an influence in the development of courses by the Motorcycle Safety Foundation and the Sidecar/Trike Education Program. An award winning author, David L. Hough was inducted in to the AMA Motorcycle Hall of Fame in 2009 in recognition of his lifetime efforts towards motorcycle safety. David is the author of Proficient Motorcycling: The Ultimate Guide to Riding Well and other books about safety and riding techniques. His books are available on Amazon at http://www.amazon.com/David-L.-Hough/e/B001JOWE2I. Grant Johnson: Rainy Weather Riding Grant's vast background includes being a motorcycle mechanic and dealer, as well as co-owner of Horizons Unlimited with his wife, Susan Johnson. Grant has given many talks around the world as part of the HUBB presentations. He's also a co-host on ARR RAW: www.adventureriderradio.com/raw Horizons Unlimited: www.horizonsunlimited.com Chantal Simons: Chick on a Chook Chaser Chantal Simons has ridden motorcycles in Asia, Europe and Australia. It was the trip around Australia that inspired her to write a book called She'll be right! Tales and Thoughts of a Women's Motorcycle Adventure Down Under. Chantal says that the reason she wrote the book was: "to show it isn't hard to do a trip like this. Some people think you have to be some super hero to travel long distances on a motorbike. But really you just need the will to go and a decent amount of common sense." Website: http://chickonthechookchaser.com YouTube: https://www.youtube.com/channel/UCIIRDqmSiS65nEapMCnuOTw Get the ebook at: Kobo Amazon Kindle Show Sponsors Max BMW BestRest Products Green Chile Adventure Gear Motobriiz TourUSA IMS Products Music by Jason Shaw at www.audionautix.com
Between 1440 and 1450, Johannes Gutenberg invented the printing press. But, history shows that printing has been around long before Gutenberg's invention. As early as 220, the Chinese were block printing, putting ink on wooden blocks and pressing them on cloth and then hundreds of years later, on paper. Before the press was invented, Europeans either painstakingly copied written word by hand or used a method similar to the Chinese block printing called Xylography. Both were laborious and time consuming, and because of this, book choices were limited and costly. But, it was Gutenberg who facilitated books being mass produced throughout Europe at a fraction of the cost. So, it's with thanks to Gutenberg that we have so many books available to us to learn or to immerse ourselves in for pleasure. Authors can take us on adventures, to the places they have been, describing the sights, sounds and smells in such vivid detail that we feel we are there, experiencing it for ourselves. We also read inspirational books that teach us to appreciate life, to feel good and get the most out of it we can. And books that teach us about things, show us how-to or teach us some much needed skills. For going on to 2000 years, humans have been reading the written word. We are so fortunate to have books easily available to us, to keep a book on the shelf to read over and over again or to refer to when we need to know something. There's something special about holding a book in your hand and turning the page. Or, the next best thing, for those of us limited in space, or travelling, or just trying to keep costs down, are downloadable eBooks. Or if you are tight for time, you can listen to someone read a book on CD or download it to hear it. And, of course, since motorcycles are our passion and yours, we have been lucky to have some fantastic authors on our show and have compiled a list of some of these authors. But, there are many, many authors out there who we haven't had on the show, who have written valuable, informative or just plain entertaining books. Peruse your local book store, or check out some authors websites. Pick a book, or two, and put up your feet and take a trip to South America, India, Africa, Europe or wherever your heart desires, plan a motorcycle adventure, or learn a thing or two about riding or repairs. Guest: Graham Field talks about books and Bulgaria - http://grahamfield.co.uk/ California Lane Splitting Made Legal - Will it Pave the Way? California is the first state to legalize motorcycle lane splitting in Bill No. 51. David Hough, author of Proficient Motorcycling and other books, comes on to ARR to talk about this new bill, what lane splitting is and what it's going to change, if anything. https://leginfo.legislature.ca.gov/faces/billNavClient.xhtml?bill_id=201520160AB51 Author List (in no special order) Ted Simon: http://jupitalia.com/ Sam Manicom: http://www.sam-manicom.com/books/ Graham Field - http://grahamfield.co.uk/ Sjaak Lucassen: http://www.sjaaklucassen.nl/en/ Dr. Gregory Frazier: Amazon Ara Gureghian - http://theoasisofmysoul.com/ David Hough - Amazon Steve Mason - Amazon Mike Fitterling - http://www.roaddogpub.com/ Shirley Hardy-Rix & Brian Rix - http://www.aussiesoverland.com.au/ Bernard Smith - http://worldtour.org.uk/ Linda Bootherstone-Bick - http://www.lindab.id.au/ Lois Pryce - http://www.loisontheloose.com/ Robert Wicks - Amazon Carla King - http://carlaking.com/ Glen Heggstad - http://www.strikingviking.net/ Nathan Millward - http://www.nathanmillward.com/ Nick Sanders - http://www.nicksanders.com/ Simon Pavey - http://www.worldrider.com/blog/ Jeremy Kroeker - http://www.oscillatorpress.com/ Allan Karl - http://www.worldrider.com/blog/ Zoe Cano: http://www.zoecano.com/ ARR is Brought to You By: Max BMW Motorcycles Shop our Online Store featuring parts diagrams for every BMW model. Ordering parts and accessories has never been easier. Choose your bike, look at the diagrams and place your order. We have over 45,000 parts in-stock and our Parts Express team processes and ships orders six days a week via UPS, FedEx and USPS. www.maxbmw.com BestRest ProductsHome of the CyclePump Tire Inflator, TireIron BeadBrakR, EZAir Tire Gauge, and other adventure motorcycle gear. When you’re on the road you’ll want a compact and reliable method of tire inflation. The CyclePump runs off your bike’s electrical system and it’ll fill a flat tire in less than 3 minutes. It’s made in the USA and it comes with a 5-year warranty. BestRest also makes tire changing and tire repair kits that are small enough to fit in your saddlebag. The crew at BestRest are adventure riders themselves, so they know what you’ll need when you’re exploring the world. www.CyclePump.com AerostichThe best way to ride more is to make riding your easiest, fastest way to get from A to B…simple everyday commuting and errands, long-distance adventure riding, or whatever. For 33 years Aerostich has been designing, making and selling equipment that makes riding anywhere, in all-weather – easier, safer, more comfortable and more fun. No other riders’ gear offers the proven protection, precise fit or lifelong value of an Aerostich. Prove it to yourself with the Ride-More Guarantee. If you try any Aerostich one piece R-3 or Roadcrafter Classic suit for one month, and are not riding more than you did before receiving it, send it back and you will receive a full refund, no questions asked. For complete details and to view all of the available equipment for riders, and for a 10% discount on your first Aerostich purchase, or free shipping on the next order for existing customers, visit www.aerostich.com/arr. Puget Sound Safety Off RoadPSS Off Road provides world class motorcycle training to new and avid motorcyclists. Since 1996 they have been dedicated to offering programs that suit the interests and needs of adventure, dual sport and dirtbike riders. Their training programs are skill focused, catering to all types of bikes and riders. Learn from top notch instructors with decades of riding and travel experience. Riders aged from as young as 6 to 60+ will benefit from one of their multi-day training camps or tours. www.pssor.com Green Chile Adventure GearOffering American made heavy-duty, innovative motorcycle luggage systems for all types of motorcycles. Tested in extreme weather conditions and terrain to withstand any abuse you can throw at it on your adventure rides. To complement riders’ needs they are also the exclusive USA distributor of Outback Motortek, a Canadian company specializing in adventure and touring motorcycle protective accessories. Outback Motortek offers ultimate and essential protection for your adventure bike. These accessories could be your best investment to save you from replacing your damaged bike with the ever-expensive factory parts. Available at www.GreenChileAdv.com.
Following his retirement from a long career as an air traffic controller, David Hough started writing in 20903. Since then he has written over 20 books, which have been published in three countries by four different publishers. #davidhough #author #conversations with authors #alisonthompson #prooffairy #writing