Podcasts about igg

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Lisa: Hi Dr Cabral! I am starting to travel a lot for my job, and I am wondering if I should be concerned about going through the XRay machines at airport security several times a year? I am also curious if you think the check in using Clear (where they scan your retinas) are safe. I was considering signing up, but I wanted to get your thoughts first. Thanks!   Ashley: Hello Dr. Cabral! I have been listening to your podcast and following your protocols since I was diagnosed with an autoimmune disease called undifferentiated connective tissue disease in 2018. I am currently doing the CBO protocol after completing a 7 day detox. I feel so much better and down about 7 pounds! I am about a week and a half in to the CBO protocol. My only issue is that I am experiencing constipation, loose stools, and afternoon fatigue. Also having so muscle pain at night that feels like “growing pains”. I was recently diagnosed with periampullary diverticulum of the gallbladder, and was told by my GI specialist that this might be why I have a hard time digesting seeds and nuts and probiotics would help. From personal experience I have struggled to find a decent probiotic that worked for me. I don't know much about this diagnosis. In February 2022 I did a candida test which was negative. I also did an igG 184 food panel and had lots of sensitivities which indicated leaky gut. In May 2022 I completed a SIBO test which was also negative. I'm just wondering if anyone had any experience with periampullary diverticulum of the gallbladder and if I should continue to follow the sensitive food guide as is when I know I don't have SIBO or candida overgrowths? Thank you!   Amanda: Hi Dr. Cabral, I've listened to your methylation podcasts & know I have issues bc of genetic testing. The problem is, the SNPs I have showing red aren't the ones you mentioned in your podcast. I read that I should avoid methyl Bs because of having COMT/TXNRD2 A4251G TT risk alleles combined with COMT V158M AA risk alleles & COMT H62H TT risk alleles (all three are red for me) because this means I have trouble breaking down dopamine, epinephrine, norepinephrine and estrogen: "It has been clinically observed that the body may have trouble tolerating methyl donors (folate, B12, methionine, betaine, choline) with a COMT V158M + and a VDR Taq + status.” Also said with lower COMT activity to avoid supplements w/ catechol structure - quercetin, EGC/G, and luteolin (which you said help methylation). My B6 is low (0.96) but B12 looks okay (1.2) and I was advised to take your Activated B complex, but I'm nervous about the methyl Bs after reading above. My brother also has low B6 and vit C and has seizures if he ever misses doses of Keppra. My question is whether you know anything about these other SNPs, if you advise supplementing with B6 only, or if I can somehow get more genetics guidance through your practice?   Carol: Thank you so much for helping me with the main Dr Cabral detox and the heavy metal detox. I feel better. My question is about treating hematochromosis, where some people build up excess iron in the body, especially the liver Normal treatment is frequent blood donation. My question is, is the metal detox going to help this? How about the regular detox? Thanks Carol   Alicja: Hi Dr. Cabral, I hope you are doing well. My question is about Adrenal Sooth suplement. I learned from your podcasts that the best is to take it at night, or at lunch and then again after dinner. My highest stress is always in the morning and first half a day. Is it ok to take Adrenal Sooth with breakfast? Or would that slow me down too much and made me feel a bit sluggish during the busiest time of my days. Big THANK YOU for your amazing work.   Cathy: Hi Dr Cabral, I am so happy to have found you several weeks ago. I work with a wonderful Holistic Chiropractor and she is following you as well, she has me on a parasite cleanse and I did a liver cleanse beforehand in January. My question has to do with a friend who has Fragile X-Associated Tremor Ataxia Syndrome (FXTAS.) Apparently, she is a "carrier" of the gene and has an adult son with autism who has the RNA gene. I looked on your recent podcasts to research but didn't find anything. Thank you in advance for any info you might share and I look forward to working with you and your staff in the future. Cath   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/2431 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

Dr. B gives the listeners important steps to get your child's immune system back on track. He begins the episode with the “why” and finishes with simple steps to implement now to begin the rebuilding process for your child. You will learn about 6 common foods to avoid. Why you should do a IGG blood food test. How much probiotic to give your child, and what antimicrobial to use.

Continuing on from the Crops Forum which was held recently, on this week's episode of the Tillage Edge podcast, you'll hear from moderator Andy Doyle discussing the issue of fertiliser supply and costs with Kieran McEvoy from the IFA, Clive Carter from IGG, as well as Donal Maloney from Tirlán, Enda McDonald from Grassland Agro, Bill Callanan from the Department of Agriculture, Food and the Marine, and Teagasc's tillage specialist, Ciarán Collins.  Podcast SurveyIn order to understand the aspects of podcasts which are most appealing and beneficial to you the listener, it would be appreciated if you could take 3-4 minutes to complete the following survey to give your feedback:  https://forms.office.com/r/mDZTE9zPy4 For more episodes and information from the Tillage Edge podcast go to:https://www.teagasc.ie/crops/crops/the-tillage-edge-podcast/ Produced on behalf of Teagasc by LastCastMedia.com

The Crops Forum was held recently with an excellent line up and a very interesting discussion from a panel of experts across the country.    And on this week's episode of the Tillage Edge podcast, you'll hear from moderator Andy Doyle discussing the financial risks of the year ahead with Kieran McEvoy from the IFA, Clive Carter from IGG, as well as Donal Maloney from Tirlán, Enda McDonald from Grassland Agro, Bill Callanan from the Department of Agriculture, Food and the Marine, and Teagasc's tillage specialist, Ciarán Collins. Podcast SurveyIn order to understand the aspects of podcasts which are most appealing and beneficial to you the listener, it would be appreciated if you could take 3-4 minutes to complete the following survey to give your feedback:  https://forms.office.com/r/mDZTE9zPy4 For more episodes and information from the Tillage Edge podcast go to:https://www.teagasc.ie/crops/crops/the-tillage-edge-podcast/ Produced on behalf of Teagasc by LastCastMedia.com

Join Dr. Danielle Belardo and her expert of the week, pediatric allergist and immunologist Dr. David Stukus, for a myth-busting episode about food allergies, intolerances, and "sensitivities." Danielle and David crack down on food "sensitivity" scams and unnecessary, unvalidated tests that people all over social media are falling victim to. Even allergies have a dark side, so tune in to learn what is fact and what is, simply, fiction.         Danielle and David discuss:        The basic terminology and meaning of food allergies, sensitivities, and intolerances   The difference between IgG and IgE and why IgG testing isn't validated or accurate   Low histamine diets and the pseudoscience claims these diets make  How to use a trial, elimination, and reintroduction diet to discover food intolerances   Why an oral food challenge is the gold standard for allergy testing   Ways to find a provider to get an accurate allergy diagnosis    Red flags for spotting allergy misinformation on social media      David Stukus, MD, is a Professor of Clinical Pediatrics in the Division of Allergy and Immunology. Prior to becoming the director of the Food Allergy Treatment Center, Dr. Stukus started the Complex Asthma Clinic at Nationwide Children's Hospital in 2011, which treats children with severe or difficult-to-treat asthma. He holds multiple leadership positions in the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the American College of Allergy, Asthma, and Immunology and is one of twelve allergists invited as a member of the Joint Task Force for Practice Parameters. He is the Social Media Medical Editor for the AAAAI, where he produces and hosts their podcast "Conversations From the World of Allergy." He has been named a Top Doctor in Pediatric Allergy every year since 2015.    Thank you so much for taking the time to contribute to a generation that values fact over fiction! Be sure to rate, review, and follow on your favorite podcast app and let us know which not-so-wellness trend you'd like to hear debunked. Follow your host on Instagram @daniellebelardomd and the podcast @wellnessfactvsfiction. All studies discussed can be found @wellnessfvfjournalclub. Follow Dr. Dave @allergykidsdoc.   Thank you to our sponsors for making this episode possible. Check out these deals just for you:  COZY EARTH - Go to cozyearth.com and enter WELLNESS at checkout to SAVE thirty-five  Percent.  ZOCDOC - Go to zocdoc.com/wellness and download the Zocdoc app for FREE. Then start your  search for a top-rated doctor today. 

Are you wondering why you're more and more limited in the foods you can eat? Or perhaps you have been diagnosed with IBS, SIBO, or another digestive condition with no known etiology. This week, Lindsay offers a look into the world of our relationship to food, food sensitivities we have, and how we can begin to shift our perspective on foods that can help ease physical symptoms. Lindsay also explains how the topic of food sensitivities is informed by toxic diet culture, some reasons why you might see some foods as “dangerous,” and how to live a life without fearing food.  Show Notes: -Basic overview of the information food sensitivity tests allow -Deep diving into IgG – the meaning – and asking the question, “Why is my body responding like this food is dangerous?” -Toxic diet culture and how that impacts our perception of food -Why we can be empowered in our own healing journeys, knowing they are unique and individualized -Information on the stress response and the fluctuating cortisol levels we experience - information on histamine and MAST cells -Examples on how the brain impacts the body with food – addressing SIBO, Leaky Gut, and food sensitivities -Why we need to stop always looking at the tests and start looking at how our bodies are responding -Pausing to ask ourselves, “What does food allow me? What does it represent for me?” -Using conscious thought to start to change subconscious beliefs and associations to foods - simple tools we can start to use with ourselves & our families Resources: -Link to the Rewire: The Vital-Side Membership -Lindsay's Instagram: @myvitalside -Visit Lindsay's website -Cait's Instagram: @caitrossco -Visit Cait's Website Join our community: bit.ly/rewirethepodcast Podcast disclaimer can be found by visiting: bit.ly/rewiredisclaimer

Forensic Genetic Genealogist Colleen Fitzpatrick joins "Mind Over Murder" co-hosts Bill Thomas and Kristin Dilley to tell us the story of how she and an international team of experts cracked a 74 year old mystery in Australia-- who is the Somerton Man, whose body was found on a sandy beach near Adelaide in 1948? This is part 2 of 2 parts.Dr. Colleen Fitzpatrick and the Identifinders Team:https://identifinders.com/about/Smithsonian Magazine: Have Scholars Finally Identified the Mysterious Somerton Man?New DNA analysis suggests a body found on a beach in Australia in 1948 belongs to Carl Webb, an electrical engineer from Melbournehttps://www.smithsonianmag.com/smart-news/have-scholars-finally-identified-the-mysterious-somerton-man-180980540/NYTimes: DNA Researchers Name the Somerton Man, Australia's 73-Year-Old Cold Casehttps://www.nytimes.com/2022/07/26/world/australia/somerton-man-name.htmlEugene Robinson in the Washington Post: (White) Women We Love https://www.washingtonpost.com/archive/opinions/2005/06/10/white-women-we-love/ce35c1c2-3e4b-40da-9236-d26a69ab4d91/Othram DNA Solves: You can help solve a case. Help fund a case or contribute your DNA. Your support helps solve crimes, enable the identification of John & Jane Does, and bring closure to families. Joining is fast, secure, and easy.https://dnasolves.com/Join the discussion on our Mind Over Murder and Colonial Parkway Murders pages on Facebook.Mind Over Murder on Facebook: https://www.facebook.com/mindoverpodcastColonial Parkway Murders Facebook page with more than 14,000 followers: https://www.facebook.com/ColonialParkwayCaseYou can also participate in an in-depth discussion of the Colonial Parkway Murders here:https://earonsgsk.proboards.com/board/50/colonial-parkway-murdersMind Over Murder is proud to be a Spreaker Prime Podcaster:https://www.spreaker.comNew Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!We launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/New Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!https://lovethepodcast.com/jpHq3qWe launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/All rights reserved. Mind Over Murder, Copyright Bill Thomas and Kristin Dilley, Another Dog Productions/Absolute Zero Productions

Join Dr. Jeffrey Gladden as he speaks to Madelynn Walker, who has a degree in Nutrition from Texas A & M. Madelynn is Gladden Longevity's in-house nutritionist, innovative and experienced, skilled in conducting nutrition assessments and evaluating lifestyle factors. They talk about common questions from clients regarding nutritional testing, food sensitivity testing, their diets, and their plans. This episode also gives you insight into how people orchestrate their diets. They also get granular here and make specific recommendations about where to get the best meat, what kind of unpasteurized milk to buy, and what kind of bars are actually healthy. If you want to start making better and more informed choices, this is for you.    Show notes:    Dr. Gladden introduces Madelynn Walker. (2:08)  Dr. Gladden states that healthy food may not be healthy for an individual. He also mentions that most diets start with food instead of the individual and why that is a problem. (2:55)  Madelynn talks about the MRT being one of the most accurate food sensitivity blood tests. (4:09)  Madelynn mentions that the MRT is so much better because it does not just look at one mechanism but considers all of them. (6:00)  Madelynn notes that IGG isn't exactly the most useful test with sensitivities because high levels of IGG can either be good or bad. (8:20)  Madelynn reiterates that food sensitivities are complex and hard to pinpoint. (10:04)  Dr. Gladden touches on how people eating certain foods will show sensitivity to those foods. (12:30)  Madelynn brings up the importance of having a well-balanced diet and changing food regularly to avoid or combat food sensitivities. (13:55)  Madelynn clarifies that there could be a margin of error in food sensitivity testing. (16:00)  Dr. Gladden asks Madelynn about her recommendations if a person's MRT test does not indicate sensitivity to gluten and dairy. (19:05)  Madelynn explains why unpasteurized milk is a better option than pasteurized milk. (21:20)  Madelynn also adds that for those interested in cow and dairy, it is crucial to get them from a reliable source. (23:20)  Madelynn educates us on seed oils and how they are excessively hydrogenated. (25:10)  Dr. Gladden points out how keeping one's oil in the refrigerator makes it difficult to use. (27:10)  Madelynn tells us about Yacon syrup and how it has been shown to have really great gut benefits. (29:36)  Dr. Gladden mentions Terry Cochran as being a big proponent of taking farm-based food. (32:10)  Madelynn emphasizes that getting your animal protein from organic sources is really important. (34:10)  Dr. Gladden introduces the issue of how eating and diets become unpredictable when people travel for vacations and things like that. Asks Madelynn for advice. (36:15)  Madelynn lists out some of the best healthy bars she knows of. (38:20)  Madelynn shares her top three things for overall health and longevity. (40:12)     Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well.  Follow us on social media!  Instagram: @gladdenlongevity  Twitter: @gladdenlongevit  Facebook: @GladdenLongevity  Madelynn's Healthy Bars Recommendations:  REDD Bar  IQ Bar  Aloha Bar  Real Food Bar 

Investigators Lou Barry and Geg Overacker of "Private Investigations for the Missing" discuss 17 year old Brianna Maitland's 2004 disappearance in northern Vermont with "Mind Over Murder" hosts Bill Thomas and Kristin Dilley. This episode originally ran in November 2020. This is Part 1 of 2 parts.Vermont State Police and Othram Partner to Investigate Brianna Maitland's DisappearanceMore than 15 years after she vanished, advanced DNA testing is being used to re-examine evidence in the Brianna Maitland disappearance:https://dnasolves.com/articles/brianna-maitland/Private Investigations for the Missing:https://investigationsforthemissing.org/MISSING: Brianna Maitland Facebook Group:https://www.facebook.com/groups/BriannaMaitlanOthram DNA Solves: You can help solve a case. Help fund a case or contribute your DNA. Your support helps solve crimes, enable the identification of John & Jane Does, and bring closure to families. Joining is fast, secure, and easy.https://dnasolves.com/Join the discussion on our Mind Over Murder and Colonial Parkway Murders pages on Facebook.Mind Over Murder on Facebook: https://www.facebook.com/mindoverpodcastColonial Parkway Murders Facebook page with more than 14,000 followers: https://www.facebook.com/ColonialParkwayCaseYou can also participate in an in-depth discussion of the Colonial Parkway Murders here:https://earonsgsk.proboards.com/board/50/colonial-parkway-murdersMind Over Murder is proud to be a Spreaker Prime Podcaster:https://www.spreaker.comNew Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!We launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/New Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!https://lovethepodcast.com/jpHq3qWe launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/All rights reserved. Mind Over Murder, Copyright Bill Thomas and Kristin Dilley, Another Dog Productions/Absolute Zero Productions

The Union Ministry of Health (MoH) approved Bharat Biotech's Covid-19 nasal vaccine, Incovacc, for emergency use in India on Tuesday. Union health minister Mansukh Mandaviya announced the development on Twitter. With this, India will no longer have to depend only on the intramuscular shots that were hitherto available. But what are nasal vaccines? There are several methods of administering a vaccine. The most common is the intramuscular vaccine, where the shot is delivered into the muscle. In subcutaneous vaccines, the shot is delivered between the skin and the muscles. Vaccines may also be delivered orally, as in the case of Polio drops. However, in nasal vaccines, the shot is sprayed into the nostrils and inhaled. Several viruses enter the human body through the mucosa. These tissues line the nose, mouth, lungs, and digestive tract. When it enters the body, the immune cells get activated and flock to the site of infection to stop its spread. In the case of nasal vaccines, the virus may be stopped from entering the body by attacking it at its point of entry. How do vaccines work? When a vaccine is administered to a human body, the B cells in the blood start churning out antibodies. The most important of these are called IgG antibodies. They search for the virus in the body and, with the help of T cells, destroy the infected cells. How do nasal vaccines work? B cells, however, also reside around the mucosal tissues. When a nasal vaccine is administered, they form another type of antibody, IgA. IgA with T cells destroys the pathogens in the airway only. Also, they memorise the pathogen and prevent it from entering the body ever again. How is a nasal vaccine better than the usual ones? There are three main reasons why nasal vaccines are better than intramuscular ones. First, these vaccines reduce the administration cost as they do not need syringes and needles. Second, Nasal vaccines can be easily self-administered. They do away with the dependence on trained individuals. Third, as the virus is not allowed to enter the body, the symptoms, if any, are mild. How will Bharat Biotech's nasal vaccine be administered? Bharat Biotech's Incovacc will have a two-dose schedule. The first dose would involve a total of 4 drops with 2 in each nostril. The second dose will have to be repeated within 28 days. This second dose would also involve a total of 4 drops, 2 in each nostril.

Today we are talking about Selank and its potential benefits. All this and more in less than 2 minutes.  What is Selank? Selank is a lab-made peptide that was made by combining the naturally occurring peptide tuftsin with another sequence to make it more stable. Tuftsin makes up a large part of the natural antibody IgG. This antibody in our blood helps prevent infections.  What are the BENEFITS?  You may hear Selank referred to as the “anti-anxiety” peptide or a “nootropic.” In clinical trials, it has been shown to provide an anti-anxiety effect. It does this by affecting GABA. GABA is an inhibitory neurotransmitter. It slows down your brain by blocking signals in your central nervous system. It produces a calming effect and can reduce stress, improve sleep, and relieve anxiety. Selank works by enhancing the effect of GABA, thus reducing anxiety. While most traditional anxiety prescription medications can cause bothersome side effects, clinical studies have shown that Selank doesn't. You should not experience side effects like drowsiness, dependence, or withdrawal symptoms.  In addition to its anti-anxiety benefits, Selank stabilizes blood enkephalins. Enkephalins are natural peptides found in the brain that help with stress.  Its nootropic actions improve cognitive function, attention, memory, and motivation. Selank increases the amount of brain-derived neurotrophic factor (BDNF), an important brain growth compound in the hippocampus that helps with learning and memory. Other studies have shown Selank to increase levels of IL-6, an inflammatory protein in the body that helps fight off infections. It's also shown to decrease blood sugar and prevention of weight gain. This could be very helpful for those with metabolic syndrome.  How do I take Selank? Selank is given as an intranasal (into the nose) spray daily. You should not use more than you're prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Selank. Possible side effects include headaches. Also, since it's a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience.  You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide therapy information together in one easy place. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week! Pro Tips Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container. We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

This month—two studies on COVID-19! Daniel R. Goldstein, MD, Editor-in-Chief of JHLT, is taking a short break, so the episode is hosted by Digital Media Editor Erika Lease, MD. Both COVID-19 studies come from the September issue of The Journal of Heart and Lung Transplantation, and in the episode, you'll learn more about each study and their authors.   First, the editors speak with Yael Peled, MD, Medical Director of the Heart Transplant Service at the Sheba Medical Center in Ramat Gan, Israel. She's the first author on a paper entitled “Fourth BNT162b2 vaccination neutralization of omicron infection after heart transplantation.” Dr. Lease and Marty Tam, MD, interview Dr. Peled about the study, which examples how IgG and neutralizing antibodies responded to a fourth BNT162b2 dose in heart transplant recipients against the omicron and delta variants versus the wild-type virus.   Next, we hear from C.T. Gan, MD, PhD, Consultant in Respiratory Medicine and Lung Transplantation at University Medical Center Groningen, on his study, “The effect of COVID-19 on transplant function and development of CLAD in lung transplant patients: a multicenter experience.” Dr. Lease and Van-Khue Ton, MD, discuss the study with Dr. Gan, including questions on management strategies for COVID-19 in lung transplant patients, lung function improvements after COVID-19 recovery, and potential follow up studies.   Follow along in the September issue at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.   This episode of JHLT: The Podcast, but not the studies within, is sponsored by Bayer Pharmaceuticals.

Forensic Genetic Genealogist Colleen Fitzpatrick joins "Mind Over Murder" co-hosts Bill Thomas and Kristin Dilley to tell us the story of how she and an international team of experts cracked a 74 year old mystery in Australia-- who is the Somerton Man, whose body was found on a sandy beach near Adelaide in 1948? This is part 1 of 2 parts.Dr. Colleen Fitzpatrick and the Identifinders Team:https://identifinders.com/about/Smithsonian Magazine: Have Scholars Finally Identified the Mysterious Somerton Man?New DNA analysis suggests a body found on a beach in Australia in 1948 belongs to Carl Webb, an electrical engineer from Melbournehttps://www.smithsonianmag.com/smart-news/have-scholars-finally-identified-the-mysterious-somerton-man-180980540/NYTimes: DNA Researchers Name the Somerton Man, Australia's 73-Year-Old Cold Casehttps://www.nytimes.com/2022/07/26/world/australia/somerton-man-name.htmlEugene Robinson in the Washington Post: (White) Women We Love https://www.washingtonpost.com/archive/opinions/2005/06/10/white-women-we-love/ce35c1c2-3e4b-40da-9236-d26a69ab4d91/Othram DNA Solves: You can help solve a case. Help fund a case or contribute your DNA. Your support helps solve crimes, enable the identification of John & Jane Does, and bring closure to families. Joining is fast, secure, and easy.https://dnasolves.com/Join the discussion on our Mind Over Murder and Colonial Parkway Murders pages on Facebook.Mind Over Murder on Facebook: https://www.facebook.com/mindoverpodcastColonial Parkway Murders Facebook page with more than 14,000 followers: https://www.facebook.com/ColonialParkwayCaseYou can also participate in an in-depth discussion of the Colonial Parkway Murders here:https://earonsgsk.proboards.com/board/50/colonial-parkway-murdersMind Over Murder is proud to be a Spreaker Prime Podcaster:https://www.spreaker.comNew Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!We launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/New Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!https://lovethepodcast.com/jpHq3qWe launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/All rights reserved. Mind Over Murder, Copyright Bill Thomas and Kristin Dilley, Another Dog Productions/Absolute Zero Productions

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.30.505953v1?rss=1 Authors: Liu, F., Su, S., Zhang, L., Fang, Y., Cui, H., Sun, J., Xie, Y., Ma, C. Abstract: Background: Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that Fc{gamma} receptor I (Fc{gamma}RI) is expressed in the neurons of the dorsal root ganglion (DRG) and may be involved in chronic pain. Methods: Chronic constriction injury (CCI) was used to induce neuropathic pain in rats. Primary neuron-specific Fcgr1 conditional knockout (CKO) rats were established by crossing rats carrying a Fcgr1loxP+/+ with the PirtCRE+ line. Behavioral and molecular studies were conducted to evaluate the differences between wild-type and CKO rats after CCI. Results: We first revealed that CCI activated neuronal Fc{gamma}RI-related signaling in the DRG. CCI-induced neuropathic pain was alleviated in CKO rats. C-reactive protein (CRP) was increased in the DRG after nerve injury. Intraganglionic injection or overexpression of the recombinant CRP protein in the DRG evoked pain accompanied and activated neuronal Fc{gamma}RI. CRP-evoked pain was significantly reduced in CKO rats. Furthermore, microinjection of native IgG into the DRG alleviated neuropathic pain and the activation of neuronal Fc{gamma}RI-related signaling. Conclusions: Our results indicate that the activation of neuronal CRP/Fc{gamma}RI-related signaling plays an important role in the development of pain in CCI. Our findings may provide novel insights into the neuroimmune responses after peripheral nerve injury and might suggest potential therapeutic targets for neuropathic pain. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Dr. Jessica Grossman is the CEO of an early stage biotech, IgGenix, the world leader in discovering and characterizing IgE antibodies which have been identified as the cause of allergies.  With an initial focus on peanut allergy, IgGenix is developing a plan to use a subcutaneous injection to block specific allergic reactions immediately. Jessica explains, "At IgGenix, what we do is start with whole blood donations from allergic donors. And we take that blood and isolate out the single B cells that are making the IgE antibodies. We get those IgE antibodies, and we transform them into an IgG antibody that's actually protective. And I'll use again, peanut as an example. That's our lead program, which we're the furthest ahead. We have done some pre-clinical work, some animal studies, which look remarkably promising, and I'm excited about it. But what we envision our therapy looking like is an antibody therapeutic that would be given to an individual, and the antibody would immediately protect them from any accidental exposure." "So we isolate these very rare B cells that produce IgE antibodies, and they're about 0.05% of the circulating blood cells. Because the IgE antibodies are so rare, they're also extremely potent, meaning they have a very high affinity. And when you are allergic, they seek out the food that you're allergic to and cause this immediate reaction. What we're doing is taking those very potent IgE antibodies, converting them to IgG antibodies to act as blockers." #IgGenix #FoodAllergyResearch #AllergicDisease #BCells #AntibodyTherapeutics #AirborneAllergies #EnvironmentalAllergies #SustainableInnovation #WomenInSTEM #Biotech IgGenix.com Download the transcript here

Dr. Jessica Grossman is the CEO of an early stage biotech, IgGenix, the world leader in discovering and characterizing IgE antibodies which have been identified as the cause of allergies.  With an initial focus on peanut allergy, IgGenix is developing a plan to use a subcutaneous injection to block specific allergic reactions immediately. Jessica explains, "At IgGenix, what we do is start with whole blood donations from allergic donors. And we take that blood and isolate out the single B cells that are making the IgE antibodies. We get those IgE antibodies, and we transform them into an IgG antibody that's actually protective. And I'll use again, peanut as an example. That's our lead program, which we're the furthest ahead. We have done some pre-clinical work, some animal studies, which look remarkably promising, and I'm excited about it. But what we envision our therapy looking like is an antibody therapeutic that would be given to an individual, and the antibody would immediately protect them from any accidental exposure." "So we isolate these very rare B cells that produce IgE antibodies, and they're about 0.05% of the circulating blood cells. Because the IgE antibodies are so rare, they're also extremely potent, meaning they have a very high affinity. And when you are allergic, they seek out the food that you're allergic to and cause this immediate reaction. What we're doing is taking those very potent IgE antibodies, converting them to IgG antibodies to act as blockers." #IgGenix #FoodAllergyResearch #AllergicDisease #BCells #AntibodyTherapeutics #AirborneAllergies #EnvironmentalAllergies #SustainableInnovation #WomenInSTEM #Biotech IgGenix.com Listen to the podcast here

This episode of Have You Herd? is sponsored by Elanco Animal Health, manufacturer of Vira Shield. Find out more information about Vira Shield at this link and the scours vaccine we discuss on the podcast on this page.  Our topic is the importance of a colostrum management program to the health, welfare and productivity to calves. Our guest is Dr. Phillip Jardon, Elanco Technical Service Consultant, and we discuss the veterinarian's role in conducting colostrum audits to monitor and improve the colostrum program on the dairy. Jardon discusses the 5 “Qs” of colostrum management which include Quality, Quantity, Quickness, sQueaky clean and Quantify. In addition, we discuss the importance of cooling the colostrum rapidly and feeding at body temperature. The veterinarian is the ideal resource to monitor a colostrum program. Jardon discusses “go to the Gimba” which means “go to where the work is done” and visually observe what is happening on the dairy. We also discuss the importance of using tools to support visual observation such as evaluating colostral and serum IgG with a refractometer, culturing colostrum for bacterial overgrowth, using temperature logging devices (HOBO's), and using a luminometer to check sanitation of all equipment.  Veterinarians can implement colostrum auditing services immediately on client operations to improve calf health and the success of the dairy by incorporating these tips.Links and publications: Consensus recommendations on calf- and herd-level passive immunity in dairy calves in the United StatesJ Dairy Sci, Vol. 103, Issue 8, August 2020 Dairy Calf and Heifer Association Gold StandardsStandards for dairy calves developed by the Dairy Calf and Heifer Association Calf NotesWebsite of calf resources in printable format developed by Dr. Jim QuigleyCalf Facts Resource LibraryWebsite of calf resources in printable format developed by Dr. Sam Leadley at Attica Veterinary Associates P.C.   

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I've been talking about leaky gut since about 2002. At the time, I was experiencing severe migraines, and my daughter (whom I was breastfeeding) had severe colic. That's when I figured out that I had leaky gut, and I had to find a way to help us both. I tried every kind of food panel and diet change, and experienced minimal benefits, until I found a lab that ran a highly accurate IgA and IgG panel and saw that I was reacting to many of the foods I ate. One of the most common misconceptions is that there is something wrong with the food panel, but that is far from the truth. The truth – which I found after reading hundreds of research articles, helping thousands of patients, and trying many versions of my treatment regimen – is that the definition of leaky gut is that we react to foods that we eat often. That means – if you react to the foods you eat, you have leaky gut. The next clarification is that you don't have to have digestive symptoms to have leaky gut. And leaky gut is caused by stress – which we all have! So the question is not WHETHER you have leaky gut. It's to what degree? I'm happy to see a lot more people talking about leaky gut lately. It's finally gaining more acceptance as a concept – which is great. But new patients still come to me with a lot of misconceptions. So if you've been wondering whether leaky gut is underlying your chronic health issue, then this episode should be able help. Sign up for my free Heal Leaky Gut Masterclass here: https://drdoni.lpages.co/leaky-gut-masterclass/     -   Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Books and Resources:    Order My New Book: https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576   Stress Warrior Book (FREE)  HTTPS://DOCTORDONI.COM/STRESSWARRIOR      Stress Warrior Stress Resiliency Facebook Group (FREE)  HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR     7-day Stress Reset (FREE)  HTTPS://DOCTORDONI.COM/STRESS-RESET     HPV & Cervical Dysplasia Guide (FREE)  HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/     -   Personalized Solutions:    If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH     To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.

This week we are finally back and welcome 3 creators that currently have projects on IGG. First, we talk to the creators behind SPORKMAN and their current project SPEARHEAD, Eric Berry and Charles Bonetti. We then finally get to talk to Kurt Zauer as he returns to the show, and we talk about SPECTRESS and SEBANION. Join Specks and JW as they hold down the fort and talk comics on COMIC BOOK GEEKS podcast SPEARHEAD - https://www.indiegogo.com/projects/spearhead--2 SPECTRESS & SEBANION issues 1-4 - https://igg.me/at/SandSIssue4

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Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Gut B cell dysbiosis in ulcerative colitis (Nat Med) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News topic du jour: https://twitter.com/davidludwigmd/status/1552636115139514368 Podcast Questions: 1. Chronic Wasting Disease in Deer and Elk [15:52] Kristi says: Hi Robb and Nicki, I have a new fear just when I am already worried about the future of meat, transportation, the economy, etc. I bought some elk liver from a ranch that sells grass-fed bison, elk, and beef. I went to fry it, and it did not smell the same as bison or beef liver. And while I'm sure that's just how elk liver smells, I started worrying about chronic wasting disease(CWD), which Joe Rogan brought up on the March 2020 episode with the infectious disease epidemiologist, Michael Osterholm. (The episode that in my mind started off the covid pandemic.) I ended up throwing away the elk meat, and then looked into chronic wasting disease more. So far, no known cases have spread to humans as vCJD (variant Creutzfeldt–Jakob disease), but that was also true of mad cow disease, and I'm sure chronic wasting disease showing up in humans will take longer since way fewer people eat elk or deer. I am in one of the areas of North America where chronic wasting disease is present, and since I bought the meat from a farm, the elk is apparently tested (they send away the heads to get tested), however it says this doesn't guarantee they're free of CWD. Now I think I should just stick to beef/bison, since the downside of Jakob Creutzfeldt disease is so terrible, but I was also thinking if I do this I shouldn't even buy bison or beef from the same farm, since prions are notoriously hard to destroy, and would stick around on the butchering equipment. Do you have any knowledge or insight on this topic? Am I overreacting? Thanks and keep up the great work with the show. 2. Digestion Woes [23:40] Kelly says: Hi Robb and Nicki, hoping you can help me with everyone's favorite topic, poo! I'll cut to the chase. My BMs are a 6-7 on the Bristol stool chart, every day. Usually 3 times per day, and all before 9 am. This has been going on for a few months now. I don't have any stomach pain or bloating, just really liquid poo. My diet is good, I eat mostly red meat, eggs, fruit, white rice, and I don't exclude dairy or gluten because I've never had any sensitivity to it, but maybe that's a good place to start? I do drink alcohol a couple times per week, but haven't noticed a difference when I remove alcohol. I am also a coffee drinker, but I hope that's not the culprit! Just looking for your thoughts on the best place to start, anything I should ask my doctor to run test-wise? I had an IgG test done a couple years ago and that didn't show anything to avoid except things like chia seeds and some random things like that. Thank you both for all you do, me and my hubs listen every week and appreciate your common sense approach to health and recent policy topics. Robb and Nicki for President! 3. Organic? [29:08] Mark says: Hi Robb & Nicki, I've read Wired & Eat & Sacred Cow & drink LMNT (love, chocolate salt in goat milk is a favorite). I've been reading some of the comments from the FarmBabe basically that she now goes out-of-the-way "not" to buy/eat food labeled Organic (she seems not to like StoneyField or at least would like them to stop spreading misinformation) .  I've also read some of her battles with "Bobby" aka FlavCity.  It's hard to sort out if what she's saying is true or if as a non-organic farmer she's biased in any way.  Any insight would be helpful, especially considering current food prices.  I seem to always want to buy Organic, am I wasting my money? All the best, Mark Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte packets to keep you at your peak! They give you all the electrolytes want, none of the stuff you don't. Click here to get your LMNT electrolytes Transcript: You can find the transcript at the blog page: https://robbwolf.com/2022/07/29/chronic-wasting-disease-in-deer-digestion-woes-avoiding-organic-foods-thrr118/

Join us in the bonus episode where Branson Reese comes back as Hoagie Allin and Tim Platt plays a member of the Fun Bunch, Art. Also, make sure to go check out Oddity Roadshow's IGG before it ends on July 31st, 2022!!! igg.me/at/oddityroadshow

- When relatable things happen to public figures - CeCe Moore's novel approach to difficult IGG cases - Is something happening in the JonBenet Ramsey case? - Book Nook 2.0 - Epic Odyssey: Part 2 with @emmastevensgatheringplace Subscribe, Rate and Review! For help on your own case contact Julie Dixon Jackson at cutoffgenes.com

Back the IGG campaign today to ensure the existence of MEDITATIONS VOL. 1 on VINYL!!! ▶️ https://igg.me/at/meditations (https://igg.me/at/meditations)

Today's episode is hosted live at the American Dairy Science Association Annual Meeting. It's the first in our three-part series from the ADSA meetings where we are featuring graduate and post-doc students and their research. We have confirmed the future of the dairy research industry is bright hands with the next generation of leaders we had the opportunity to interview.Effects of maternal dietary rumen-protected choline supplementation during late gestation on calf growth and metabolism.Joining us is Turner Swartz from Michigan State University discussing his poster on the effects of maternal dietary rumen-protected choline during late gestation. In general during the study, calves born to pre-natal treated cows showed lower amounts of oxidative stress and reduced inflammation. Studies on these calves ended at 21 days, but it is possible if the study had continued through weaning, that the choline supplementation could have resulted in better calf growth. Additionally, cows that received choline produced 80% more colostrum than the control group, without diluting the IGG's. For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/5-Effects-of-maternal-dietary-rumen-protected-choline-supplementation-during-late-gestation-on-calf-growth-and-metabolism.pdfChanges in plasma and milk choline metabolite concentrations in response to the provision of various rumen-protected choline prototypes in lactating cows.Joining us is Tanya France and Dr. Joe McFadden from Cornell University discussing her research on the effects of choline. The goal of the study was to define the best rumen-protected choline technologies that enhance choline bioavailability. The study included two different experiments featuring mid and late-lactation cows. Varying doses of choline chloride were given as a ruminal bolus to the cow and measured the plasma in milk over the course of 36 hours. For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/3-Changes-in-plasma-and-milk-choline-metabolite-concentrations-in-response-to-the-provision-of-various-rumen-protected-choline-prototypes-in-lactating-cows.pdfRumen-protected choline (RPC) reduces hepatic triacylglycerol content by increasing hepatic triglyceride-rich lipoprotein secretion.Joining us is Usman Arshad from the University of Florida discussing his research on choline reducing hepatic triacylglycerol content. The study analyzes the effects of choline on reducing fatty liver at the cellular level, much more granular than studies done in the past. In the study the effect of choline was isolated, which proved that choline is a lipotropic agent that should be fed with other agents such as methionine. In the experiment, feeding choline resulted in fewer cows with fatty liver, which means better health and milk production. For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/1-Rumen-protected-choline-RPC-influences-hepatic-metabolism-during-induction-of-fatty-liver.pdfhttps://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/2-Rumen-protected-choline-RPC-reduces-hepatic-triacylglycerol-content-by-increasing-hepatic-triglyceride-rich-lipoprotein-secretion.pdfRumen protected choline (RPC) influences hepatic metabolism during induction of fatty liver.Joining us is Usman Arshad from the University of Florida discussing his research on how rumen-protected choline influences metabolism. For the study, cows were induced with fatty liver via caloric restriction, then fed them a diet high in fatty acids. Then they looked at triacylglycerides in the blood and collected lymphatic fluid. The study found that triacylglycerol levels were increased in both the blood and lymphatic system which suggests that choline increases digestibility of nutrients concurrent with enhanced absorption of triacylglycerols. The study also found that choline reduces inflammation in cows, which could result in less mastitis or matritus. Choline could actually impact the immune function of the cows. For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/1-Rumen-protected-choline-RPC-influences-hepatic-metabolism-during-induction-of-fatty-liver.pdfIncreasing dose of prepartum rumen protected choline: Effects on milk production in Holstein dairy cows and Increasing dose of prepartum rumen protected choline: Effects on energy and nitrogen metabolism in Holstein dairy cowsJoining us is Dr. Henry Holdorf from the University of Wisconsin-Madison discussing his research on postpartum and prepartum rumen protected choline. These studies focused on higher producing cows, as they were second or greater lactation cows. The results of feeding rumen-protected choline still created an increase in milk production. While the cows had high intakes, they were very typical in size for a midwest dairy cow. An area of interest that requires more study is if choline impacts mammary gland function or rumen health and supply of nutrients. Considering carry-over effects that happen after stopping choline supplementations makes it a subject requiring more study. For more details, view the abstract summaries here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/7-Increasing-dose-of-prepartum-rumen-protected-choline-Effects-on-milk-production-in-Holstein-dairy-cows.pdfhttps://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/8-Increasing-dose-of-prepartum-rumen-protected-choline-Effects-on-energy-and-nitrogen-metabolism-in-Holstein-dairy-cows.pdfIncreasing dose of prepartum rumen-protected choline: Effects of in utero exposure on growth and feed efficiency in Holstein dairy calves.Joining us is Dr. Henry Holdorf from the University of Wisconsin-Madison discussing his research on increasing the dose of rumen-protected choline and its effect on growth and feed efficiency via in utero exposure. The results of the study showed that higher doses of rumen-protected choline in the first two weeks of life increased the average daily gains and feed efficiency than the control group. For this experiment the choline was mixed into the ration, so the intake of choline by the cow was dependent on her dry matter intake. An important takeaway is that there are additional benefits for postpartum cows and their calves than what is established with choline. It's a chance to help young, vulnerable animals. For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/9-Increasing-dose-of-prepartum-rumen-protected-choline-Effects-of-in-utero-exposure-on-growth-and-feed-efficiency-in-Holstein-dairy-calves.pdfIncreasing dose of prepartum rumen-protected choline: Effects of in utero exposure on Angus x Holstein beef calves and Effects of in utero choline exposure on growth and metabolism in weaned Angus X Holstein calves.Joining us is Dr. Henry Holdorf and Dr. Billy Brown from the University of Wisconsin-Madison discussing their research on in utero choline exposure in crossbred calves. The study by Dr. Holdorf fed choline mixed into the daily ration to prepartum cows and resulted in the male holstein/angus calves having improved rates of gain from three to eight weeks of age. It was linearly increasing with the increase of choline ingested by the cow. The results were not the same for female calves. Dr. Brown continued the study after weaning of the calves by weighing them monthly and discovered there was a tendency of increased body weight, hip and wither height. For producers, this allows them to gain value on calves right out of the gate, as the average difference in growth was approximately 30 pounds difference between the control group and the highest dosage of choline. For more details, view the abstract summaries here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/11-Effects-of-in-utero-choline-exposure-on-growth-and-metabolism-in-weaned-Angus-X-Holstein-calves.pdfhttps://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/10-Increasing-dose-of-prepartum-rumen-protected-choline-Effects-of-in-utero-exposure-on-Angus-x-Holstein-beef-calves.pdfEffects of dietary rumen-protected choline supplementation during an intramammary lipopolysaccharide challenge in periparturient dairy cattle.Joining us is Turner Swartz from Michigan State University discussing the effects of choline supplementation. The hypothesis of the study is that choline supplementation increases milk yield due to a reduction in inflammation. To prove this, cows were put into inflammation with a lipopolysaccharide (LPS) challenge, which traditionally would decrease milk yield. The study found the choline response was greater than the LPS response. Choline increased milk production by 3kg per cow per day. The LPS was reducing production by 2kgs per cow per day.  For more details, view the abstract summary here: https://balchem.com/animal-nutrition-health/wp-content/uploads/sites/3/2022/06/4-Effects-of-dietary-rumen-protected-choline-supplementation-during-an-intramammary-lipopolysaccharide-challenge-in-periparturient-dairy-cattle.pdfIf you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you. Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  This podcast is sponsored by Balchem Animal Nutrition and Health. This podcast is sponsored by Balchem. All views expressed by the guests are the opinions of those individuals and are not the views of the Balchem, its affiliates or employees. 

The Fun Bunch has to face their final hurdle before getting to the pegs, their creator!!! Joel Ruiz as the GM. Paul Byron, Shelby Lee, and Shannon Strucci as ther players. Featuring Branson Reese as Infinity Nakedness. Check out our IGG campgin for our new show, Oddity Roadshow! It runs until July 31st, 2022! https://igg.me/at/oddityroadshow

Emergencies happen in hematology and oncology. This is a fact. But how do we manage these emergencies? Look no further. In this episode, we talk all about our third hematologic emergency: heparin-induced thrombocytopenia (HIT)!Be sure to check out episode 009 on thrombocytopenia for a general approach and differential!HIT:- Any time a patient with heparin exposure and now with a new thrombotic event, you need to think about HIT!What is HIT?- Type 1: a transient drop in platelets after heparin is started- Type 2: **The scary one! Antibody-mediated process**Heparin molecules bind to platelet-factor 4 (PF4)**This complex activates platelets, which then further releases more PF4 from the plateletsWhat is the difference between HIT and HITT?- HITT is when there is also thrombosis (HIT + Clot) Why is this more common in the cardiac ICU?- It is believed that IgM interacts with ultra-long complexes, which heparin is- Lots of heparin is required for cardiac surgery- Therefore lots of exposure to heparin increases likelihood, increasing likelihood for IgM to IgG class-switching; HIT is IgG-mediated process** Remember - since this is antibody-mediated, therefore it takes a few days for the antibodies to form in patient with a new diagnosis of HIT!How to stratify?4-T score (MDCalc Link: https://www.mdcalc.com/4ts-score-heparin-induced-thrombocytopenia)Workup: - Sent HIT ELISA test in patient with high suspicion - ELISA just suggests if the HIT antibody is present- If ELISA positive, then do confirmatory assay, i.e., is this antibody actually doing anything, is the "serotonin-release assay” - Send 4 extremity dopplers to look for thrombosis - STOP heparin/heparin-derived products and SWITCH anticoagulant, such as argatroban, fondaparinux, bivalirudin (do not wait for a positive test if your suspicion is high enough!)If HIT positive: - Add heparin to their allergy list- Continue anticoagulation until platelets are recovered (>150K)- Continue anticoagulation for 3-6 months for patients with HITTWords of wisdom: If patient comes from outside hospital and starts having decreasing platelets, consider HIT in your differential! References: https://ashpublications.org/blood/article/119/10/2209/29530/How-I-treat-heparin-induced-thrombocytopenia- great review article from ASH on HITPlease visit our website (TheFellowOnCall.com) for more information Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this VETgirl online veterinary continuing education podcast, we discuss a point-of-care (POC) antibody assay for Coccidioides in dogs. Coccidioides is a systemic fungal infection also known as Valley Fever, common in the southwest United States and parts of northern Mexico (Brown). The fungal organisms live in the soil, but unfortunately can become aerosolized and inhaled, leading to disease. Affected dogs often suffer from respiratory disease, but a quarter of cases can result in more serious, disseminated infections (Davidson). In a study entitled "Clinical performance of a point-of-care Coccidioides antibody test in dogs" by Reagan et al, the authors dive into the diagnostic options available for detecting Coccidioides, and they offer a quick and helpful review of the available options. Briefly, several diagnostic options are available, though cytology, histopathology, or fungal culture represent the gold standards. An agar gel immunodiffusion (AGID) assay is used commonly in dogs to detect IgM or IgG against fungal antigens, but this test is expensive, has certain technical challenges, and varies in performance. Additionally, an enzyme immunoassay can also be performed for rapid antibody detection, but this assay still requires sending samples to a reference laboratory. Lastly, an immunochromatographic lateral flow assay (LFA) is another type of rapid detection assay that detects antibodies against two Coccidiodies antigens. This is a POC test that can be performed in approximately 30 minutes! Therefore in the current study, the authors sought to determine the agreement between this LFA and the standard AGID assay in dogs with suspected coccidioidomycosis.

In this bonus episode, hosts Bill Thomas and Kristin Dilley discuss the "Canal Killer" case in Phoenix, Arizona, which was cracked by Colleen Fitzpatrick using Investigative Genetic Genealogy (IGG) techniques in partnership with the Phoenix Police Department. The suspect goes to trial later in 2022. This is Part 2 of a 2 part discussion. AZCentral: Judge: Man Charged in Canal Killings Mentally Fit for Trial (Jan. 2022):https://www.azcentral.com/story/news/local/arizona/2022/01/06/judge-ruled-bryan-patrick-miller-mentally-fit-canal-killings-trial/9121344002/AZCentral: How Forensic Genealogy Led to an Arrest in the Phoenix 'Canal Killer' casehttps://www.azcentral.com/story/news/local/phoenix/2016/11/30/how-forensic-genealogy-led-arrest-phoenix-canal-killer-case-bryan-patrick-miller-dna/94565410/Goodreads Kathryn Miles "Trailed" Book:https://www.goodreads.com/book/show/58328366-trailedOthram DNA Solves: You can help solve a case. Help fund a case or contribute your DNA. Your support helps solve crimes, enable the identification of John & Jane Does, and bring closure to families. Joining is fast, secure, and easy.https://dnasolves.com/Join the discussion on our Mind Over Murder and Colonial Parkway Murders pages on Facebook.Mind Over Murder on Facebook: https://www.facebook.com/mindoverpodcastColonial Parkway Murders Facebook page with more than 14,000 followers: https://www.facebook.com/ColonialParkwayCaseYou can also participate in an in-depth discussion of the Colonial Parkway Murders here:https://earonsgsk.proboards.com/board/50/colonial-parkway-murdersMind Over Murder is proud to be a Spreaker Prime Podcaster:https://www.spreaker.comNew Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!We launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/New Article in Virginia Gazette: 35 Years Later, Victims' Families in Colonial Parkway Murders Still Searching for Answers, Hope DNA Advances will Solve Case By Em Holter and Abigail Adcoxhttps://www.dailypress.com/virginiagazette/va-vg-colonial-parkway-murders-anniversary-1024-20211022-76jkpte6qvez7onybmhbhp7nfi-story.htmlNew Article in Medium: The Colonial Parkway Murders — A Tale of Two Killers? By Quinn Zanehttps://medium.com/unburied/the-colonial-parkway-murders-a-tale-of-two-killers-1e8fda367a48Washington Post: "Crimes of Passion"https://www.washingtonpost.com/archive/opinions/1997/08/15/crimes-of-passion/0a38e8f9-6d04-48e4-a847-7d3cba53c363/New feature article in the Daily Beast: "Inside the Maddening Search for Virginia's Colonial Parkway Serial Killer" By Justin Rohrlichhttps://www.thedailybeast.com/what-happened-to-cathleen-thomas-and-rebecca-dowski-inside-the-hunt-for-the-colonial-parkway-killerCitizens! Check out our new line of "Mind Over Murder" t-shirts and other good stuff !https://www.teepublic.com/stores/mind-over-murder-podcast?ref_id=23885Washington Post Op-Ed Piece by Deidre Enright of the Innocence Project:"The FBI should use DNA, not posters, to solve a cold-case murder" https://www.washingtonpost.com/opinions/2021/06/25/julie-williams-laura-winans-unsolved-murder-test-dna/Oxygen: "Loni Coombs Feels A Kinship To 'Lovers' Lane' Victim Cathy Thomas"Loni Coombs felt an immediate connection to Cathy Thomas, a groundbreaking gay woman who broke through barriers at the U.S. Naval Academy before she was brutally murdered along the Colonial Parkway in Virginia.https://www.oxygen.com/crime-news/loni-coombs-feels-a-kinship-to-colonial-parkway-victim-cathy-thomasYou can contribute to help "Mind Over Murder" do our important work:https://mindovermurderpodcast.com/supportFour one-hour episodes on the Colonial Parkway Murders are available on Oxygen as "The Lover's Lane Murders." The series is available on the free Oxygen app, Hulu, YouTube, Amazon, and many other platforms. https://www.oxygen.com/lovers-lane-murders Oxygen" "Who Were The Colonial Parkway Murder Victims? 8 Young People All Killed In Virginia Within 4 Years" https://www.oxygen.com/lovers-lane-murders/crime-news/who-were-the-colonial-parkway-murder-victims Washington Post Magazine: "Victims, Families and America's Thirst for True-Crime Stories." "For Bill Thomas, his sister Cathy's murder is a deeply personal tragedy. For millions of true-crime fans, it's entertainment." https://www.washingtonpost.com/news/magazine/wp/2019/07/30/feature/victims-families-and-americas-thirst-for-true-crime-stories/Daily Press excellent series of articles on the Colonial Parkway Murders: "The Parkway" http://digital.dailypress.com/static/parkway_cottage/main/index.htmlColonial Parkway Murders website: https://colonialparkwaymurders.com Mind Over Murder Podcast website: https://mindovermurderpodcast.comPlease subscribe and rate us at your favorite podcast sites. Ratings and reviews are very important. Please share and tell your friends!https://lovethepodcast.com/jpHq3qWe launch a new episode of "Mind Over Murder" every Monday morning, and a bonus episode every Thursday morning.Sponsors: Othram and DNAsolves.comContribute Your DNA to help solve cases: https://dnasolves.com/user/registerFollow "Mind Over Murder" on Twitter: https://twitter.com/MurderOverFollow Bill Thomas on Twitter: https://twitter.com/BillThomas56Follow "Colonial Parkway Murders" on Facebook: https://www.facebook.com/ColonialParkwayCase/Follow us on InstaGram:: https://www.instagram.com/colonialparkwaymurders/Check out the entire Crawlspace Media network at http://crawlspace-media.com/All rights reserved. Mind Over Murder, Copyright Bill Thomas and Kristin Dilley, Another Dog Productions/Absolute Zero Productions

The Investigation I know how confusing and frustrating it can be living with hypothyroidism and or Hashimoto's because there is so much information out there about Hashimoto's and hypothyroidism.  At the same time, there is also not that much that really focuses on these specific conditions. This is why I get so many questions every time I check in with you through Instagram and my email list. After posting in my IG stories this week, I got a ton of questions and I am so excited to answer them for you. Before I do, I want to remind you that Hashimoto's and thyroid issues are very individual - there is no ‘one size fits all' solution. That's why I created a much more in depth training and you can access it absolutely free RIGHT HERE!  Let's dive into your questions. I got over 300 questions, but many of them were similar or around the same theme so I'm focusing on the most frequently asked questions in this episode of Health Mysteries Solved.   The Question #1 How can I lose weight with hypothyroidism or Hashimoto's? (and many other variations of this question). Inna's Response  As I mentioned, dealing with your thyroid condition is not one-size-fits-all and neither are the weight management strategies. It is very individual based on your thyroid type and your genetics.  However, one common issue is gluten intolerance. Gluten tends to be a trigger for people with autoimmunity especially if they have the DQ2 and the DQ8 Genes. These genes make it difficult for the body to process gluten and instead your body may attack it by making an antibody to gluten. This may cause cross-reactivity where your body is not only attacking the gluten but accidentally attacking other tissues like the thyroid.  Another common food sensitivity is dairy. This can be a major trigger. For me, it showed up as skin issues (including redness and hives) as well as gas and bloating. I was able to determine dairy as the culprit because when I stopped having dairy, these symptoms went away.  Sugar is another food that many with Hashimoto's may want to reconsider eating. Sugar can offset our blood sugar very quickly and can cause quite a bit of inflammation. This does not help us deal with Hashimoto's because there is often already inflammation.    The Question #2 How do I choose what to try first with dietary changes? Should I do the AIP, go grain-free, gluten-free, dairy-free, sugar-free? Inna's Response  There is not a short answer to this question because it depends on so many different factors. If you are quite in-tune with your body, you may have an idea of what is causing an issue for you. In this case, test your suspicions by eliminating that item from your diet and see if you feel better.  You could also get a food sensitivity test but make sure that you are doing a test that has multiple immunoglobulin pathways as many basic tests only look at one. I like the Zoomers tests from Vibrant Wellness because they test for different pathways including IGG, IGA and IGE as well as testing the components of the different foods.  Another option is to do a full elimination diet following the AIP (Autoimmune Protocol) until you get the inflammation down and then introduce things one at a time to discover your triggers.    The Question #3 What dietary changes should I make to help me lose weight with Hashimoto's or Hypothyroid? Inna's Response  For some, getting rid of dairy or gluten significantly reduces inflammation and that helps them retain less water and lose weight pretty quickly.  However, I think for many of us, I would probably say most of us, it's not that easy (but it's not impossible!) There's a lot that goes into weight loss. First and foremost, you want to make sure that you're supporting your thyroid if your thyroid levels are not optimal. It is going to be very, very hard to lose weight if your thyroid is in a slow state and not activating your metabolism. So, make sure to support your thyroid for your thyroid type (be sure to check out my free training for more on this).  Secondly, consider your metabolic type. Some of us are ‘carb type' and some are ‘protein type' if you are not eating according to your type, it will be very difficult for your metabolism to do its job and help you maintain or lose weight.  And finally, if you are following a protocol or plan and not seeing results, then you may want to switch it up.    The Question #4 What supplements should I take if I am a vegetarian with Hashimoto's? Inna's Response  The answer to this question depends on a couple of things. A vegetarian diet can be very healthy but you want to make sure that you're getting enough protein, B12 and iron. This is especially true for specific thyroid types, so if you are a vegetarian you want to figure out your thyroid type. Check your iron and B12 levels and be sure to supplement if they are low.    The Question #5 What is the best type of exercise for Hashimoto's or Hypothyroid? Inna's Response  If your thyroid is supported (and your levels are optimal) and you are doing everything you can to calm and balance your immune system (avoiding Hashimoto's flare ups), then you can do any kind of exercise you like.  I like to do high intensity interval training (HIIT) because I like to do quick spurts and I find that I can fit it into my busy day. Weight-bearing exercises are also very good because you get your metabolic rate going and it stays active with you for hours and hours after you've worked out. I also like to do the Lagree Method of Pilates. This is done on a transformer and it is a full body workout.  However, if you're still working on balancing your thyroid hormones or you find yourself in a Hashimoto's flareup, then you will want to avoid strenuous exercise. When your thyroid is flaring and the autoimmunity is flaring, your body is in an inflammatory stress state. Exercising in this state can increase that stress. You will know if you are doing this because you will feel physical strain and fatigue right after the workout.    The Question #6 Why are there so many different symptoms with Hashimoto's? Inna's Response  This is such a great question and I love talking about this (check episode 100 which is dedicated to Hashimoto's symptoms). The reason why Hashimoto's has so many symptoms is because there are two areas affected - the thyroid and your immune system.  When you have Hashimoto's you will typically have a less than optimal thyroid function because your thyroid is under attack. Getting your thyroid levels balanced will help with some of the symptoms.  People with Hashimoto's are also dealing with inflammation caused by the immune system attacking your thyroid. When these attacks happen, the inflammation can show up anywhere on the body. It could be your joints causing aches and pains. It could be the brain causing brain fog.  We can have inflammation on our skin causing acne, rashes, eczema or other types of dermatitis.  To avoid the symptoms, your support for Hashimoto's has to be twofold, you have to support the immune system to stop that inflammation in the attack and also support the thyroid.   The Question #7 What is the relationship between Vitiligo and Hashimoto's? Inna's Response  Vitiligo causes spots on the skin and some people with Hashimoto's experience this. However, I don't think there is a specific relationship between Vitiligo and Hashimoto's per se. Vitiligo is an autoimmune condition as is Hashimoto's. Unfortunately, when you have one autoimmune condition, your immune system may not be balanced and that opens the door for other autoimmune issues.  This is not to say that because you have Hashimoto's you will develop other autoimmune conditions but you want to support the immune system as much as you can because the immune system controls everything.    The Question #8 Is it possible to be hyperthyroid before becoming hypothyroid? Inna's Response  Yes, it absolutely is. This can happen when you have Hashimoto's. The thyroid tends to go up and down, it kind of swings in both directions especially when there is a Hashimoto's flare up. With flare ups, it can go up and down, back and forth. In this case, the state of hyperthyroidism is temporary.    The Question #9 Are there vitamins I should be taking for my thyroid? What is a good multivitamin for people with Hashimoto's? Inna's Response  Vitamin or supplement support for your thyroid depends on your thyroid type so it is quite individualized.  As for a multivitamin, you want to make sure that you pick a multivitamin that doesn't have a lot of iodine because it's contraindicated. You also want to make sure that you have a nice balance of all of the B vitamins and all of your minerals. Now, when it comes to B vitamins, there are methylated B vitamins, there are synthetic B vitamins and they're also B vitamins that are unmethylated but natural and not synthetic. It's very helpful to know your methylation status when selecting a multivitamin.  If you haven't heard about your methylation status, check out episode 108. It's actually a fairly simple test. For Hashimoto's, I like to use the Designs for Health Complete Multi and it comes with iron and copper or without iron, depending on what you need. And that's great for those who are undermethylators. If you are an over methylator, a great one is Optimal Multi Minus ONE (Methyl Free)  Eliminating Health Mysteries When it comes to optimizing your health with Hashimoto's or hypothyroidism, you can find that missing piece of the puzzle and feel good again. Could one of the things mentioned today be the missing clue for you or someone in your life?    Links: Resources mentioned: Discover Your Thyroid Type - Free Training   Suggested Products:  Zoomer Tests from Vibrant Wellness Designs for Health Complete Multi with Iron and Copper DFH Complete Multi without Copper and Iron   Related Podcast Episodes: Top 5 Mistakes When Navigating the Many Symptoms of Hashimoto's - Health Mysteries Solved The Case of Fatigue and Brain Fog Made Worse by B Vitamins - Health Mysteries Solved [Ask Inna] Answers to Your Questions about Hypothyroidism and Hashimoto's [Ask Inna] Your Thyroid and Hashimoto's Questions Answered [Ask Inna] More Answers to Your Hashimoto's Questions (Part 2) Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode -  Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show! Find out more at http://healthmysteriessolved.com   PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses. 

Our 'Focus on NUTRITION' month continues, with once again episodes from the Sports Therapy Association Podcast being uploaded here to Runchatlive as nutrition is obviously  a tpic of relevance to runners & professionals who work with runners. If you want to join the live recordings, head to The Runchatlive Facebook Page or Sports Therapy Association YouTube Channel every Tuesday at 8pm (GMT+1). In this episode, the subject is 'Food Intolerance', with special guest Dr Gill Hart, BSc (Hons), PhD, Cert Mgmt (Open), FIBMS. Dr Gill Hart is a leading UK Biochemist, an expert on food intolerance and a credible and respected authority on a range of related issues, with over twenty years experience in the development and clinical evaluation of diagnostic tests. As Scientific Director at YorkTest Laboratories ,a leading provider of food intolerance tests and food allergy tests for 40 years, Gill regularly gives talks and lectures on food intolerance at Universities, Colleges, trade shows and consumer events. She also provides guidance for those choosing diagnostic tests with her ‘What makes a good diagnostic test' checklist, and has written many articles in scientific journals and consumer magazines. Topics discussed in this episode include: The history of food intolerance testing and how YorkTest became the UK's leading food intolerance, allergy and home health testing company. The difference between an allergy and a food sensitivity The prevalence of food intolerance worldwide and in the UK Different types of food intolerance and the tests available Symptoms of food intolerance Immunoglobulin G Tests - Why do we measure food-specific IgG antibodies in blood? IgG tests at YorkTesting - how blood is taken, how food-specific IgG reactions are measured, how results are collated A look at the evidence for food-specific IgG tests being effective How soft tissue therapists & practicioners can work alongside YorkTest, and how can tests be ordered Useful Links   YorkTest Website: yorktest.com YorkTest Practitioner Account Team: Tel: 01904 410 410 Email: client.support@yorktest.co Facebook: @yorktestUK Twitter: @yorktestlabs Instagram: @yorktestUK Our sincere thanks to Dr Gill Hart for giving up her time to be on the Podcast! Please Support Our Podcast! If you appreciate what we do on Runchatlive Podcast and the Sports Therapy Association Podcast, please take a couple of minutes to leave us a rating & review. It really does make all the difference in helping us reach out to a larger audience. iPhone users you can do this from your phone, Android users you will need to do it from iTunes.

This episode is sponsored by RA Optics: Code CARNIVOREYOGI for 15% of) - https://raoptics.com/?afmc=carnivoreyogi More on poor gut health & seasonal allergies: antihistamines & dangers of long term use 1 - Let's review the conversation from last month regarding how poor gut health can cause worsening seasonal allergies - https://youtu.be/18Z4SfCB67o 2 - Can we dive into the difference between IGE & IGG allergies & how the gut plays into these. 3 - What are the effects of antihistamines on the gut ? 4 - What are the long term effects of taking antihistamines? 5 - How can Healthy Gut products stabilize mast cells & or help someone get off of antihistamines. 6 - Can allergies affect gut health/digestion/stomach acid/gut bacteria? Coupon Codes for products mentioned: Coupon Code: yogimmune for Holloimmiune HoloImmune- https://healthygut.com/holoimmune-now/?oid=10&AFFID=484152&coupon_code=yogimmun Coupon Code: yogihcl Coupon Code: yogiholo Coupon Code: yogitrix Promotion Date: 5/18/22 Coupon Expires: 5/31/22 HCL - https://healthygut.com/hcl-guard-now/?oid=2&AFFID=484152&coupon_code=yogihcl HOLOZYME -https://healthygut.com/holozyme-now/?oid=3&AFFID=484152&coupon_code=yogiholo TRIX-https://healthygut.com/tributyrin-x-now/?oid=4&AFFID=484152&coupon_code=yogitrix CUSTOMIZED PROBIOTIC THAT I USE - http://tryombre.com/CarnivoreYogi PRODUCT LINKS AFTER MAY 31, 2022 (coupon expires) HCL https://healthygut.com/product/hcl-guard/?oid=7&AFFID=484152 HOLOZYME - https://healthygut.com/product/holozyme/?oid=6&AFFID=484152 TributyrinX- https://healthygut.com/product/tributyrin-x/?oid=5&AFFID=484152 Full playlist with Steve Wright - https://youtube.com/playlist?list=PLBszj9nzso6jOadgcYpqIPbRYvERYK4q0

There are few people in our lives that have as big an impact on our careers as mentors. So, in this episode, we're thrilled to have Dr. Janet Pope back to discuss the importance of the mentor-mentee relationship in Rheumatology. Daniel and Janet discuss the benefits - and occasional challenges - of mentorships, as well as the mentors who have made a difference in their lives, how best to find and connect with a mentor early in your career, who the right mentor is for you, the difference between mentors and teachers, and what they love about being mentors themselves. If you have any questions you'd like to ask in our possible upcoming "Ask the Expert" episodes on Sjogren's Disease, Autoinflammatory Diseases, and/or IgG-4-Related Disease, please send us an email at info@rheum.ca or tag us on social media at @CRASCRRheum. Bios: Dr. Janet Pope is a Professor of Medicine in the Division of Rheumatology at the University of Western Ontario, Schulich School of Medicine, London, Ontario. She is also the Division Head in Rheumatology at St. Joseph's Health Centre in London.  Dr. Daniel Ennis is a Rheumatologist and Vasculitis Specialist at the University of British Columbia. Special Thanks: Around the Rheum is produced by the Canadian Rheumatology Association's Communications Committee.A special thank you to the podcast team, Dr. Dax G. Rumsey (CRA Communications Committee Chair), Dr. Daniel Ennis (Host), David McGuffin (Producer, Explore Podcast Productions) and Kevin Baijnauth (CRA) for leading production. Our theme music was composed by Aaron Fontwell.For more on the work of the Canadian Rheumatology Association, visit rheum.ca

When I interview Dr. Sherri Tenpenny last year, it was the first time I'd ever heard an in-depth description of Covid vaccine "shedding." That was back in May when the big push to get every man, woman, and child on earth jabbed was just getting ramped up. We were censored heavily at the time; the powers-that-be DEFINITELY did not want people concerned that those who have been jabbed might be spreading their manufactured spike proteins to the people around them.Here's an excerpt from the transcript of my interview that is eye-opening:"Well with these shots, we are not injecting a live virus, a whole virus. We're not even injecting a part of a virus. We are injecting laboratory generated messenger RNA in the the Pfizer and in the Moderna shot, and in the J&J and the AstraZeneca shot, we're injecting an adenovirus, a common cold adenovirus that's had its core shelled out, I mean, its genetic material taken out, and a piece of DNA, double stranded DNA, they call it trans gene, that has been put inside of that shell."That whole conglomerate is then injected into your body and released. The DNA is released into the cytoplasm. It makes a messenger RNA, which then makes a spike protein and that double stranded DNA, your body can make antibodies against it, which are associated with a long list of autoimmune diseases, or that double strand of DNA can get incorporated into your own genetic material."There's nothing in my language I just said in the last minute there about a virus. So it's not really shedding. But we do know something is being transmitted because we have well, the last time I looked there are over 11000 reports of women, this last time meaning a couple of days ago, there were over 11000 reports of women who had not received one of these shots or injections, but had been around people who had that weren't even necessarily close personal contacts like a spouse or an adult child or something like that."This might be just people they work with in their place of business. Like we've had reports from hairdressers that were not injected, that were around their customers that had been injected. And these women are having horrific bleeding diatheses. Some women who are postmenopausal start to bleed. They haven't bled… they're in their 70s, they've never bled before. Some women in their 30s and 40s, that their periods every month have been like clockwork, absolutely rhythmical."They're starting to bleed and they've bled so much, they've lost two thirds of their blood volume. There are younger women who are getting clots inside of their uterus that they're clotting so hard and becoming calcified that as they passed this clot, it's like passing like a miscarriage and it tears off the uterine lining on the inside."We've had reports of 22 month old girls passing clots the size of eggs. This one report that we had was a little girl, was twenty two months old, who had spent the weekend with her grandparents, both of whom had been injected. Now, I know that there is more of a bleeding diathesis problem that's been associated with the J&J shot in the AstraZeneca shot."I mean, AstraZeneca was pulled off the market in, I think, 18 or 19 countries. And how did they rerelease it to those countries? It wasn't because they did any more research or scientists came forward and said there's nothing to be concerned about. AstraZeneca issued a press release and said this is a rare condition and it's more important to get the shot so that you don't get Covid. And all the countries went OK, and they started using it again, and so… but we  also know that those bleeding tendencies of whatever is being transmitted, we don't really know."I personally, this is my own personal opinion, believe it's the spike protein. I believe that there's billions of spike proteins and it's a protein that then can last longer. And some people have said they think it's the messenger RNA. Messenger RNA is pretty unstable. And so I don't think it would last very long. But if you were having close personal contact with people like a spouse and you were hugging or kissing or having sex with with someone or or like with the grandchild and probably sitting in Grandma or Grandpa's lap, something is being transmitted that is causing horrible problems and not just bleeding problems."As I noted, we were called crazy conspiracy theorists for insinuating that these experimental drugs might be shedding onto those who had no taken them. Now a news study all but confirms that we were right all along. The sad part is that they're positioning this as a positive thing because now parents can, in part, help to "vaccinate" their children just by being around them. You can't make this stuff up.I discussed this on the latest episode of End Medical Tyranny. In it, I read parts of an article (below) by Igor Chudov who talks about the study and its implications.Before I get into Igor's article, I want to note that Dr. Vladimir Zelenko has a new nutraceutical protocol called Z-DTox. While he cannot explicitly say that he designed it to help those who have either been jabbed or who may be experiencing shedding from those around them, that's exactly what the intention of these pills really are. I'm no doctor. I can only go by what I'm told by actual medical experts.Here's the article by Igor...Vaccine Shedding Finally Proven!Statistically Significant Vaccine Shedding from Parents to ChildrenDo vaccinated people shed their vaccine byproducts to us? We definitely, for sure, knew that vaccine shedding was not a thing, because "health experts and fact checkers" told us so. And we "believe science" and our "health experts". Right?Except that it is WRONG and vaccine shedding has just been proven by science!Even I believed that there was no plausible mechanism for vaccine shedding. I thought that it was a baseless conspiracy theory. Stupid me. It turned out that I WAS WRONG and vaccine shedding is real and can be measured.A study "Evidence for Aerosol Transfer of SARS-CoV2-specific Humoral Immunity" was just released.Evaluation of samples in this fashion revealed that high intranasal IgG in vaccinated parents was significantly associated (p-value = 0.01) with a 0.38 increase in the log transformed intranasal IgG gMFIs within a child from the same household (Fig 1F).Let me try to explain it. First, these scientists from the University of Colorado looked at face masks, worn by vaccinated health care workers. They found that those workers shed antibodies generated by vaccination, and some antibodies got trapped in the masks and could be detected. This means that vaccinated people are literally "shedding" vaccine-caused antibodies.Interested in that, scientists looked further: they compared unvaccinated children living with unvaccinated parents, to similarly unvaccinated children, but living with vaccinated parents.It turned out that vaxxed parents actively shed vaccine-produced particles onto their children so that the kids acquired "humoral immunity" following shedding from their parents! Not only was this finding evident in the data, it actually was STRONGLY statistically significant with p-value of 0.01! This means that this was not a chance finding.It remains to be explained WHY children have intranasal IgG. The authors seem to think that it is because of antibody shedding via droplets. In other words, they seem to propose that what is transferred is IgG itself in saliva droplets. They may be right. That said, there is a possibility that children DEVELOP intranasal IgG because other vaccine byproducts or exosomes are being shed.It could even be due to lipid mRNA nanoparticles themselves shed and being transferred via saliva, like a virus. In fact, considering two replies to this article that I quoted at the bottom, mRNA lipid nanoparticle shedding is most likely. Why? Because the responders report experiencing STRONG IMMUNE REACTIONS.Such byproducts would be CAUSING intranasal IgG in children as an immune reaction in children, rather than those IgGs being essentially mechanically spat from parents onto their children.The article, while very interesting, is only the first step in researching vaccine shedding and I hope that further light will be shed (pun intended) on this phenomenon!The authors, possibly in hopes of getting their article approved by science censors, call it a good thing:Our results suggest that aerosol transmission of antibodies may also contribute to host protection and represent an entirely unrecognized mechanism by which passive immune protection may be communicated. Whether antibody transfer mediates host protection will be a function of exposure, but it seems reasonable to suggest, all things being equal, that any amount of antibody transfer would prove useful to the recipient host.I am not sure if I can call it a good thing myself. Antibodies or mRNA nanoparticles from vaccines NOT approved by the FDA for children are being shed from parents to children, without consent or knowledge of either parents, or children. All of this is followed by denials by authorities.Do you think that it is a good thing?Please share this article widely!(Get your Don't Shed on Me shirts from my buddy, Jeff Dornik) This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit endmedicaltyranny.substack.com

Excited to dig into the question from our listener today- "I'm having digestive symptoms and I am not sure whether to start with a food sensitivity test or stool test, can you help?!" Want an individualized approach to your care? Book a visit at www.statwellness.com Research Studies: Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder Link: https://pubmed.ncbi.nlm.nih.gov/31233833/ Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial Link: https://gut.bmj.com/content/53/10/1459#ref-21 Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899772/

For more information on this topic or to schedule a consultation please visit us at http://WhatIsHashimotos.com Hair dye, hair bleach, and Hashimoto's. So I don't really, you could go on forever if you want to tease out every single chemical that is a trigger. That's a trigger for Hashimo. So Hashimoto's is like, I've said 39. Like I think I'm about the 41 or 42 now, but it's like, it's 40, 41 triggers. And I have presentations online. I've said 39 cuz that's what there was at the time. And so the chemical sensitivities are probably a, a quarter of those like, like 25%. I, I don't even test for 'em anymore. There's controversy. Should you test it by hair? Should you do it by hair analysis? If you're going to test for them doic type PCR, antibody tests, and look for the IgG, I G a type of stuff and even IgM to make sure that you're, you don't have an allergy to it, but, but I don't even test for it. I mean that I've been doing this for a long time and I've done the testing for it and I've gone through the, oh, it's the analysis for the metals, but also for the toxins and it's urinalysis and so on and so forth and, or it's antibody testing but everything, every test I ever did, people have chemical sensitivities. I mean, I think the bottom line is more than specifically, do you have is a hair dye or bleach? Is that it's a chemical and our bodies are not designed to live in the chemical soup that we live in. That is a good example with diabetes. I know this is about Hashimotos, but there's a good example with diabetes where everybody up until like 1980 or even later said, oh, we got so much diabetes going on now because of, so we're eating so much sugar and we are, and it's a part of it, but it's interesting in the 1980s is when we really started dumping chemicals into our, into our site. It's like, like 80,000 chemicals have been introduced since then. How many of them have been actually evaluated? Well, not many, not many at all. And the ones that have been you, you, you prior to glyphosates from the, from the spraying of the, of the foods and, and the Monsanto and that whole type of thing, which is real. Okay. So, but, but that's just one, that's just one, it's just one chemical out of, out of all of those, these chemicals go in and they are, they're shown to create inflammation. They cause your liver to clog up. You, you end up getting itchy, maybe, maybe, or your liver to not be able to work. Right. And you start having all kinds of, of, of issues with detoxification, but in and of themselves, they have been shown to increase antibodies, to autoimmune diseases and particularly antibodies to to the thyroid proxies, enzymes of that caused the attack on your thyroid. http://powerhealthtalk.com http://drmartinrutherford.com Martin P. Rutherford, DC 1175 Harvard Way Reno, NV 89502 775 329-4402 http://powerhealthreno.com https://goo.gl/maps/P73T34mNB4xcZXXBA

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In this wide-ranging discussion, IgGenix CEO Jessica Grossman, M.D. discusses the application of and market opportunity for antibody therapy for severe allergies, the gender gap in the biopharma c-suite, why women work harder than men, what it means to be a female biopharma leader, and IgGenix's approach at isolating and re-engineering allergen-specific IgE antibodies into IgG antibodies designed to alleviate — and possibly prevent —  allergic cascade.

Love may come and go but Herpes is Forever is a said because there has been know know effective treat for it, until now. For the past thirty years direct intravenous ozone therapy using the Robins Method has been known to effectively eliminate, permanently, completely, once and for all.Yes, not just stop outbreaks but in many cases eliminate the need for the body to make IGG antibodies thus clinically proving cure! This show will discussion this pandemics effect on millions of lives and how to finally fix it.

AABP Executive Director Dr. Fred Gingrich is joined by Dr. Elizabeth Homerosky to discuss her research project on identifying calves at risk for not consuming colostrum within 4 hours of birth with the development of the Beef Calf Vigor Assessment (BCVA).  Homerosky is the 2021 recipient of the AABP James A. Jarrett Award for Young Leaders and a partner at Veterinary Agri-Health Services in Alberta. Find out about their practice and student opportunities at this link. Homerosky discusses the challenges of identifying calves at risk in beef production systems, especially cattle on open range.  A study from Waldner and Rosengren of the University of Saskatchewan, suggests that for optimal passive transfer, calves need 24 g/L of serum IgG and approximately 1/3 of beef calves do not achieve this optimal level of IgG. It can be difficult to assess passive transfer in beef calves versus dairy calves due to the differences in management systems. Homerosky explains that concentration of immunoglobulins in beef cattle is not considered a major risk factor, however, timing of colostrum consumption is critical for passive transfer in beef calves since we rely on the maternal-neonatal bond to allow for nursing within 4-hours. The BCVA is a practical and producer friendly tool that clients can use to identify at-risk calves. The APGAR scoring system used in human neonates has not been found to have a high association with outcomes of interest. In her study, Homerosky identified that the suckle reflex was highly associated with disturbances in blood gas abnormalities and failure of passive transfer. Adding calving ease into the algorithm and applying the BCVA to all calvings will improve the ability to identify at-risk calves. Veterinarians are encouraged to work with their beef producers to identify at-risk calves using the BCVA and providing protocols for interventions when indicated. Relevant publications: Homerosky, E. R., et al. "Clinical indicators of blood gas disturbances, elevated L-lactate concentration and other abnormal blood parameters in newborn beef calves." The Veterinary Journal 219 (2017): 49-57.https://doi.org/10.1016/j.tvjl.2016.12.001 Homerosky, E. R., et al. "Predictors and impacts of colostrum consumption by 4 h after birth in newborn beef calves." The Veterinary Journal 228 (2017):1-6.https://doi.org/10.1016/j.tvjl.2017.09.003 Waldner, C.L. and Rosengren, L.B., “Factors associated with serum immunoglobulin levels in beef calves from Alberta and Saskatchewan and association between passive transfer and health outcomes.” Canadian Journal of Veterinary Research 2009; 50:275-281

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Hannah: I have a lot of confusion around protein consumption, especially when building muscle. Do you have a rule of thumb of how much protein is needed? When working with a nutritionist online, at one point she had me at 112 g, my body weight was around 140. This number was super hard to hit if I was not down in protein bars and shakes. Protein bars and protein shakes do not agree with my stomach at all. After finding you, I'm doing the detox and running some labs to work on my gut health. I would really like to get protein from natural sources. Can you help with how much protein do you think is needed?   Gary: Hi Dr. Cabral, I have severe gut issues and I am working with a functional Dr. We have determined I have leaky gut and bacterial imbalances in the gut. I also suffer from chronic constipation. We are trying to address these things currently. I also did a food sensitivity test for IGG and had very few problems there. However, I have massive bloating and cramping in the colon with EVERY meal no matter what food I eat. I tried the pulse test for IGE and found no increase in pulse, but I am getting horrible reactions every time I eat anything. Any advice? (I know stress is making things worse and I am very stressed currently, but this seems a bit extreme to be only stress) Thank you! Gary   Mallory: Hi Dr. Cabral! I am 27 years old & have been sick since I was a toddler. I had 4 sinus surgeries by the time I was 11 and was on an insane amount of medication & antibiotics as a child (so much so that it stained my adult teeth). Ever since I've had extreme gut issues, anxiety, & more recently I've developed POTS & other auto immune issues. A year ago I learned about candida, pathogens, parasites, mold, etc. I started on my own parasite cleanse which resulted in an instant crawling sensation all over my body. I had an intense herxheimer reaction & even tested positive for the flu. Since then, I have found a local functional doctor who has ran several functional tests & currently has me on a protocol similar to yours for my immune system and detox. He believes this is the root to the vast majority of my issues. The problem today is that it's been a year and I still see visible pathogens & film-like in every single one of my bowel movements. I still feel this crawling sensation, although not at all as intense as it was a year ago. My question is: is it possible that I can feel the pathogens moving as they are being pulled out of my body? Have you seen patients who took this long to detox? Any advice is much appreciated! It currently feels like I'm still so far from being well.   Zita: Hi, What about illnesses like eating compulsive disorders or Bulimia? Can they provoke adrenal insufficiency or hypothyroidism? Kind regards, Zita   Catherine: Hi Stephen. I've been lifting for 8 years. I was a swimmer growing up. In college I went from 140-105 lbs in three years by running and eating a paleo diet. I was about 6% body fat. I gained 20 lbs by eating 2700 of a paleo diet calories in 2017. I started intuitive eating. Mid 2020, I randomly started to gain weight. I tried cutting my calories and I started binge eating as a result. I gained 50# in 8 months. I was getting debilitating migraines with aura 2019-2020. I haven't had a period since 2018. I started cutting with a coach in March of 2021. We reversed to 2300 calories and went down from there. I lost 12 lbs and plateaued in July. We tried going lower. I went down to 1200 calories (still paleo) and still did not lose weight. I believe my hormones are messed up and the binge eating is coming back. My digestion sucks and I have to take linzess. I don't know what to do at this point. I am sitting at 5'5” 156-158 lbs, 25/26% body fat based on Dexa. I still have no period. My mood and my energy are all over the place. I take progesterone but it doesn't do anything. Any tips on where to go from here? I want to get back to 140#.   Cassandra: Hi Dr. Cabral, Since probably November, I've started noticing tiny bumps on my eyelid. They have only appeared on the top lid of my right eye. It's not like a stye that I've seen people get on the main surface of the eyelid; they show up below the lash line, like where the two lids meet when you blink. They're the same color as the rest of my skin and can be scraped away with my fingernail. They don't hurt, but I'm just wondering what would cause this and if it's a sign of something I should be concerned about. Thank you. Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/2242 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -  Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)

Did you know that if you test at FamilyTreeDNA, all you have to do is check a box of approval during the DNA kit registration process, and your DNA results and online family tree are automatically opted into a program that helps investigators work to solve cold cases? I invited author J.C. Kenney to talk about the 4th book in his Allie Cobb series of mystery novels. In A Deadly Discovery, a consumer DNA test and genetic genealogy course taught at the local library lead to the solving of a decades-old murder mystery in a small town in Indiana. You need not be a true crime fan or a DNA expert to learn from today's episode! Our conversation hones in on the highlights of DNA and crime investigation and is a great intro for those unfamiliar with investigative genetic genealogy, often shortened to IGG. Things we touch on in this discussion: Resources for learning more about IGG What is a "cozy mystery" How the town of Nashville, Indiana plays into it all Things we don't address in today's discussion? Ethicals gray zones and real-life criminal cases involving consumer DNA tests. We'll have to save that for a future episode of DNA Clarity and Support with a different author! In the meantime, you can read more about this topic (and some of Brianne's thoughts about consumer DNA testing and IGG) in an article by Ariel Ramchandani in Mother Jones magazine. As we near the end of season 2 of DNA Clarity and Support and plan for a sabbatical over the summer months, we are curious to know what you think. Heard an episode this season that had an impact on you, and now you can't stop thinking about something you heard? Tell us about it! Recently finished a book related to a DNA discovery and you want to hear more from the author in a Q&A with Brianne? Send us your feedback and some questions you'd like us to ask of future guests! Season 3 is in its planning stages right now, and we need YOUR help to make it a great one! Read J.C. Kenney's novel A Deadly Discovery on your e-reader or mobile device. (Make sure to check out the first three books in the series, too.) Go back and catch up on past episodes of DNA Clarity and Support and join the mailing list at WatershedDNA.com to never miss and episode or an announcement of new resources. --- Send in a voice message: https://anchor.fm/watershed-dna/message Support this podcast: https://anchor.fm/watershed-dna/support

In this podcast, Dr. Kim Thielen, a nephrologist/kidney specialist with Minnesota Kidney Specialists joins us today to continue part 2 of our discussion on acute kidney injury, as we wade further "into the weeds"  discuss intrinsic renal disease. This episode will break down hallmark urinary findings and further subdivide intrinsic concerns into bland, nephrotic and nephritic, various causes, and treatment. Enjoy the podcast! Objectives:   Upon completion of this podcast, participants should be able to: State the 3 types of urinary analysis findings related to instrinic acute kidney injury. Describe etiology of presentation of each type of intrinsic acute kidney injury. CME credit is only offered to Ridgeview Providers & Allied Health Staff for this podcast activity. Complete and submit the online evaluation form, after viewing the activity.  Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks. You may contact the accredited provider with questions regarding this program at  rmccredentialing@ridgeviewmedical.org. To receive continuing education credit for this activity - click the link below, to complete the activity's evaluation. CME Evaluation (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.)  DISCLOSURE ANNOUNCEMENT  The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for CME/CE and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview Medical Center & Clinics.  Any re-reproduction of any of the materials presented would be infringement of copyright laws.  It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on these presentations. It remains for the audience to determine whether the speaker's outside interest may reflect a possible bias, either the exposition or the conclusions presented. Ridgeview's CME planning committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. Thank-you for listening to the podcast. SHOW NOTES: *See the attachment for additional show information.  Intrinsic Kidney Injuries: Urinary analysis findings- Bland Urine: no protein - Nephrotic: protein - Nephritic: protein and blood Hallmark Urinary Findings: Casts - Tamm Horsfall Protein : Mucoprotein made by tubular epithelial cells that precipitate out and congeal    to form casts on whatever is in the cells at the time.  (i.e. RBCs, WBCs, tubular debris) Bland Urine States- Crystalline Induced Renal Injury: obstruction and infllamatory response       - Uric Acid Neuropathy (Most common)              - Cancers, lymphomas, etc.              - Drugs: acyclovir, methotrexate, protease inhibitors, etc.              - Toxins: Ethylene glycol - Bland Urine Disease states: results from injury to tubules, instertim or pre glomerular blodd vessels, not    the filters of the kidney       - Interstital Nephritis              - Hallmark: pyuria and WBC casts                      - Biopsy: inflammatory infiltrate              - Causes:  viral, PPIs, Adenover, mizalamin, etc., Checkpoint inhibitors       - Acute Tubular Necrosis              - Hallmark: tubular epithelial cell cast                      - Granular: (course or fine) diagnostic of ATN              - Biopsy: denuded dilated tubular cells              - Causes: #1: Ischemia;  toxins, drugs, contrast dye;  pigment injury. myoglobin              - What about contrast dye?                      - Categorized under ATN                      - Per Dr. Thielen, plays a role, but injury is not solely dependent on dye alone.       - Hepatorenal Syndrome: ischemic injury to the kidney due to unopposed vasocontstriction               - Ace inhibitors cause unopposed efferent vasoconstriction + nonsteroidals cause                 unposed afferent vasoconstriction = no glomerular perfusion pressure       - Multiple Myeloma              - Hallmark: Light chain cast nephropathy or myeloma kidney                      - Light chains precipitate  out causing obstruction, inflammatory response and causes                        tubular damage              - Presentation: older possibly with anemia, bone pain and elevated creatinine with a bland urine.              - Protein to creatinine ratio: + for protein (non albumin)              - Dipstick: (which measures for albumin and not light chains) will be negative for protein aka                 bland urine       - Hypertensive Nephrosclerosis              - Small vessel vascular disease                     - Blood vessels prematurely atherosclerosis causing glomerular drop out and scarring of the                        interstim       - Scleroderma                - Limited cutaneous systemic sclerosis                - Diffuse cutaneous systemic sclerosis: 60-80% have renal injury from disease state itself                           - FANA positive                           - Concern for Scleroderma Renal Crisis = medical emergency                                   - AKI, moderate to severe HTN and bland urine                                   - Uncontrolled accumulation of collage, thickens vascular walls, narrowing and renal                                       ischemia                          - Occurs in 10-15% of those with Diffuse Cutaneous Systemic sclerosis and happens early                              in disease                                     - Left untreated: renal failure in 1-2 months and death in 1 year                          - Treatment: ACE Inhibitor Nephrotic Urine States - Urine protein: albumin excretion greater than 3.5g in 24 hours - Nephrotic Syndrome:      - Present with 3 things (nephrotic range protein, hypoalbuminemia, peripheral edema)       - Hyperlipidemia: due to increased hepatic lipogenesis                - Increased risk of renal disease and arthroscleratic       - Venous thrombotic disease:                 - Loose proteins other than albumin and develop a hypercoagulale state                 - Renal and peripheral venous thrombosis      - Lipiduria (forms fatty casts,  looks like a latese cross under microscope)  -Pathophysiology or nephrotic syndrome    - Glomerular capillary wall           - 3 layers that work as a glomerular filtration and responsible in the filtration between blood and             urine                  - Fenestrated Capillary Enothelial cells (fenestrations allow plasma through to the basement                     membrane)                 - Glomerular Basement Membrane (maintains glomerular filtration barrier; negatively charged,                     repels albumin)                 - Epithelium: Podocytes (Have highly specialized foot processes that connect and form slit                     diaphragms; Slit diaphragm important for the efficient flow of small solute and water)          - Anything that messes with any of these layers: nephrotic proteinuria - Nephrotic Disease States:     - Biopsy: anyone with nephrotic proteinuria (besides diabetics)          1) Light microscopy: high overview          2) Immunofluorescens: looks for nephritic component and identif immunce complexes          3) Electron microscopy: (EM) helps look at the ultrastructure and better identify immune deposits    - Diabetic nephropathy           - Leading cause of kidney disease in U.S. and western society           - Responsible for 30-40% of all ESRD causes           - Hyperglycemia: produces inflammatory responses, oxidative stress, and injures the podocytes and             deposits that charge and affect the ability of the kidney to filter.     - Amyoidosis            - Organize into betapleted sheets and produce spikes of the capillary uniion and poke through the               GF membrane            - Easily identified by apple green birefringence on congo red            - Terminal illness            - Present with HTN, cardiac effects and elevated creatine  - Nephrotic Disease states based of histologic appearance      - Diagnosed by histologic appearance but does not determine the etiology      - Minimal Change Disease              - Fairly common              - Minimal change under light microscope              - EM: podocytes are abnormal, fused, no unique cell-cell junction              - Primary: Immune generated circulating facture;  alters the cytoskeleton of the podocytes       - Secondary               - Nonsteriodal - most common cause of secondary minimal change disease               - Gama interferon               - Hodgkin's lymphoma               - Allergy: 30% of minimal change have associate allergy (mechanism unknown)       - Presentation               - Sudden onset (days to weeks)               - Marked edema and hypoablbuminemia               - 60% have normal blood pressure,    82% have normal creatinine - Focal Segmental Glomerulosclerosis (FSGS) - primary and secondary         - Most common cause idopathic nephrotic syndrome in adults        - Primary glomerulonephritis in the US that causes ESRD        - Widespread podocyte injury     - Primary: circulating factor that messes with regulation of foot process and adhesion to the         glomerular basement membrane (afffect all podocytes)          - Present with nephrotic syndrome and rapid progression          - HTN and elevated creatinine    - Secondary: the visceral epithelial cells don't replicate          - Nephron loss or obesity or direct foot process injury          - Cannot replicate (podocytes), leads to decreased to podo denisty at specific areas (focal injury)          - 2/3 of all cases FSGS          - Present: with slowly increasing proteinuria and kidney impairment over time          - Causes: interferon, bisphosphonates, talc, anabolic steroids    - Genetics: gene mutations that encode for the slit diaphragms of the podocytes (affect all podocytes)            - Present in Childhood: full blown nephrotic and progress rapidly to ESRD Membranous Nephropathy - Most common cause of nephrotic syndrome in caucasion adults - 80% present with nephrotic but develops more slowly to ESRD - Primary: Major antigen identified      - antibody to trans-membrane receptor that is highly expressed on the glomerular podocyte - Secondary: Cancers (lung, breast, GI), Lupus, Thyroiditis, Hep B, Syphilis, Nonsteroidals, Monoclonal    Antibodies Nephritic Syndrome - Hematuria and proteinuria    - Hematuria: blood from kidney or outside the kidney             - Outside the kidney: look the same             - Inside the kidney: dysmorphic red cells    - Present:             - Renal impairment for days to weeks             - Edmatous, HTN and look critically ill              - Vasculitis, sinusitis, oral ulcers             - Pulmonary renal syndrome: short of breath or hemoptysis             - Skin changes: bruising , bleeding, purpura             - Myalgias and arthritis     - Urine:             - Hallmark: red blood cell casts (polymorphic red cells)             - dipstick + for blood             - elevated proteinuria    - Biopsy: nephritic and + urine Nephritic Disease States (based on immunofluorescence staining) - Pauci Immune Disease         - Ankle vasculitis, common         - A paucity (little amount) of immune complexes         - See black on imaging         - Lab work: check on ANCA and peripheral eosinophils - Anti-GBM Disease         - Renal limited, or classic pulmonary renal: Good Pasture's          - linear staining of the glomerular basement with anti IGG (looks like a ribbon on a package)          - Treat with cytotoxic agents - Immune Complex          - Starry sky pattern          - Glomerulus looks dotted with stars                - Stars = immune complex definition          - Diseases:  Lupus (FANA), Post Infectious GN, Membranous Proliferative GN  - IGA Nephropathy           - Most common cause of glomerulonephritis in the world          - Presentation:                 - Peak incidence is the 2nd and 3rd decades of life                - 40-50% gross hematuria with upper respiratory and GI illness          - Risk Factors for Progression:                - younger age or hypertension at time of presentation                - > 1g proteinuria                - Elevated creatinine at time of presentation Thanks for listening.

En el podcast de hoy explicaré qué son los test de intolerancia a alimentos, en quéconsisten y cuál es su veracidad.El test de intolerancia a alimentos, normalmente a 200, es una prueba encargada de determinar los alimentos que sientan bien o mal (clasificados en rojo:peor tolerados, naranja:recomendable evitar o verde:mejor tolerados), o incluso los que ‘'engordan'' más a un individuo. El funcionamiento de este test se lleva a cabo midiendo los anticuerpos IgG, los cuales suelen estar elevados ante los alimentos que solemos consumir habitualmente, desembocando en la posible demonización del gluten, lácteos... Debemos aclarar que no existe una prueba que identifique todas las intolerancias/alergias. Además, este ensayo no tiene valor diagnóstico en contraposición con las pruebas de intolerancia a la fructosa, lactosa o sorbitol, que son las encargadas de analizar los anticuerpos IgE (alergias). Por otra parte debemos destacar su elevado precio ya que suelen encontrarse por encima de los 100€.Este tipo de test desemboca en una restricción innecesaria de X alimentos, lo cual puede generar carencias o déficit nutricional, como sería el caso de una mujer en perimenopausia a la cual le aparecen reflejados productos ricos en vitamina D o calcio, nutrientes clave en esa etapa de la vida. Además, puede alargar el diagnóstico real o empeorar la sintomatología. En algunos casos la restricción de alimentos puede provocar ansiedad. Por último aclarar que la realización de estos test de intolerancia a alimentos suele tener un interés económico oculto.

Do you have a food sensitivity? Have you ever wondered why there are so many more food sensitivity issues these days? You're not alone if you answered yes to either of these questions. On today's episode, I'm diving into what causes these sensitivities and why it's so important to know about them! I talk more…The different branches of the immune system and their roles within the bodyOne immune issue that is on the rise What you could potentially be putting in your body that is causing these food sensitivitiesWhere I see women having the most success with this issueWhat you need to heal before you can fix your sensitivities Why supporting your immune system is not only beneficial to your sensitivities but to your overall health!Don't forget to sign up for my free resource!The Functional Gynecologist's Guide to Balancing your Hormones:https://lcvjtpc8.pages.infusionsoft.net/Connect with me:Dr. Tabatha's Website: https://www.drtabatha.com/Dr. Tabatha's Facebook: https://www.facebook.com/DrTabathaDr. Tabatha's IG: https://www.instagram.com/thegutsygynecologist/Dr. Tabatha's YouTube: https://www.youtube.com/c/TheGutsyGynecologist@Dr_Tabatha was hacked on Instagram! Please report and UNFOLLOW that account. Please follow the real Dr. Tabatha @thegutsygynecologistWe can't let evil win!!@Dr_Tabatha was hacked on Instagram! Please report and UNFOLLOW that account. Please follow the real Dr. Tabatha @thegutsygynecologistWe can't let evil win!!

On this episode of Food Allergy Talk, I welcome our special guest, Dr. Alan Khadavi, board certified allergy and immunologist out of Los Angeles, California.  Dr. Khadavi is an experienced allergist assisting both adult and pediatric patients who suffer from chronic allergies, asthma, and other respiratory conditions.Dr. Khadavi recently enjoyed the privilege of being named a Rising Star in the Los Angeles edition of Super Doctors in the field of Allergy and Immunology.  He was also named Most Compassionate Doctor by the Patient Choice Awards in 2013 and 2014.  In 2013, 2014 ,2015, 2019, 2020 and 2021, he was named to Castle Connolly's list of Top Doctors. He was given the Vitals Patients' Choice Award for physicians who provide excellent care and the On Time doctor award as well. Los Angeles Magazine recently named him a “Top Doc” for its 2019-2021 editions.In this episode I sit down to chat with Dr. Khadavi about:Signs and symptoms of food allergySigns and symptoms of new additional food allergiesDifferent ways food allergy presents (hives and some "typical" presentations vs other less obvious presentations)What method to go through pediatrician and primary care physicians to investigate underlying health issuesThe top 9 allergens, multiple food allergies, and rare food allergiesIncrease in food allergy diagnosisVegetable and fruit allergy vs Oral Allergy SyndromeHow food allergies are diagnosed with focus on individual historyDifference between IgG and IgE blood testsSkin prick tests and comparison to blood tests and individual historyWhen are food challenges looked at as an optionNo such thing as a mild allergy, past reactions cannot dictate severity of future allergic reactionWhen to administer epinephrine?Epi first, and epi fastWhen requesting prescription, how many for home and elsewhere to request, expiration date and genericsExpired epinephrineFind Dr. Alan Khadavi online at: https://allergylosangeles.comYou can also follow him on Instagram: https://www.instagram.com/dralankhadavi/Listen online anytime: https://foodallergypi.com/the-food-allergy-talk-podcast/ or on any podcast player.