Podcasts about Iga

Jeff and Jim are joined by Gartner Analyst Rebecca Archambault for a special live edition of the podcast recorded at the Gartner Identity & Access Management Summit in Grapevine, Texas on December 10, 2025. Instead of a traditional interview, the trio hosts "Majority Rules," an interactive game show where the live audience votes on pressing and fun identity topics. Listen in to hear the pulse of the room on everything from the biggest buzzwords of the year and the true purpose of analyst 1:1 sessions, to the best strategies for navigating the vendor hall. The group explores audience preferences on IGA, AI risks, non-human identities, and the most common lies told in sales cycles. It is a fun, lighthearted look at what identity professionals are actually thinking about the current state of the industry.Connect with Rebecca: https://www.linkedin.com/in/rebecca-becky-archambault-4b4285111/Connect with us on LinkedIn:Jim McDonald: https://www.linkedin.com/in/jimmcdonaldpmp/Jeff Steadman: https://www.linkedin.com/in/jeffsteadman/Visit the show on the web at http://idacpodcast.comChapter Timestamps00:00 - Intro and Game Rules02:40 - First Question: Favorite Podcast03:15 - Networking vs. Education04:08 - Buzzword of the Year: Agentic Identity04:47 - User Behavior Analytics Usage05:37 - Expo Hall Memories and Socks06:20 - The Twist: Battle Royale Rules06:45 - The True Purpose of Analyst 1:1s07:55 - Mitigating Agentic AI Risks08:55 - Strategies for the Vendor Hall09:37 - The Future of IGA10:15 - Favorite Gartner Reports11:05 - Benefits of Just-in-Time Access11:45 - AI in Authentication Priorities12:35 - Securing Non-Human Identities13:05 - Keys to Successful B2B IAM 13:40 - The Hardest Part of Role Mining14:15 - PAM for AI Agents14:50 - Keynote Takeaways15:40 - Measuring IAM Success16:20 - Defining ITDR17:05 - The Biggest Lie in IAM Sales17:35 - Least Favorite Gartner Report18:10 - Audit Preparation Preferences18:45 - Common Lies in the Vendor Hall19:15 - The Most Dangerous Access Right19:35 - Winner Announcement and OutroKeywordsIAM, identity management, cybersecurity, Gartner IAM Summit, Majority Rules, game show, Rebecca Archambault, IDAC, Identity at the Center, Jeff Steadman, Jim McDonald, Agentic Identity, ITDR, non-human identity, role mining, zero standing privileges

For the first regular episode of the year (excepting our New Year's recap) we take a look at the New Year Traditions at Temmu's court.  How did the court celebrate the New Year in the late 7th century? For more, check out our blogpost:  https://sengokudaimyo.com/podcast/episode-141 Rough Transcript: Welcome to Sengoku Daimyo's Chronicles of Japan.  My name is Joshua and this is episode 141: Temmu's New Year's Traditions   The chill winter air meant that most of the assembled crowd had donned multiple layers of robes.  Men and women had assembled together, upon the open, rock-covered courtyard, both to see and be seen.  To the north and east of the courtyard were the walls and gates of the buildings that made up the royal palace, the rooves of the buildings just visible beyond the gates. The onlookers stood arrayed around the open lanes that had been created for the event—at one end of the rocky field were targets, while at the other were archers, also arrayed in their finest outfits.  While technically they wore hunting robes, cut to allow greater movement in the arm, many of these fabrics had no business being anywhere near a moor or the dirt of open fields.  After all, this wasn't just some hunt:  They were demonstrating their skills in the center of the State.  At the officials' command, the archers let loose their arrows.  The crowd murmured at the soft crack of the bowstring, the faint whisper of arrow as the fletchings cut through the air, and the thud as the arrows struck their targets.  Looking downrange, approval bubbled through the crowd: the targets were well-struck.  Behind the archers on the field, another group awaited their turn. The events of the day would be the talk of the court, from the lowest clerk to the highest prince , for days to come.   Not just the well-placed shot, but also the grace and poise of the one who had let loose an arrow of particular note.  And heaven forbid an arrow miss its target.  Even kicking up stones or scraping the earth could have negative social consequences.  A particularly good showing could inspire poetry, and beyond the prizes being offered to the winner, could also bring notice to those from more obscure backgrounds. The new year had just started, and a good performance might be just what was needed to help put the rest of the year on a good footing.     Welcome back!  This is the first episode of the new year, 2026, and we are still going through the reign of Ohoama, aka Temmu Tenno, covering the period from 672 to 686. Before we get started, though, a quick shout out to Suzuki for supporting us on Patreon.  It means a lot and helps us keep this thing going.  If you would like to support us or our efforts to maintain the website, where we also have the Armor manual, clothing, and a miscellany on various topics, we have information at Sengokudaimyo.com and we will have more information at the end of this and every episode.  Support is appreciated as I really do want to try and minimize ads—I don't put any into the podcast myself, though some platforms may place ads around the podcast, which I cannot always control.  Now we've covered a lot this reign, but this episode we are going to cover three things in particular.  First off, and perhaps a bit of a tangent, we'll talk about some of the issues with the Chronicles when it comes to reading it,especially in translation.  It seems quite clear to me that even the sources that the Chroniclers were using weren't always in agreement with each other on how they spelled certain things or even in properly recording when things happened. After that we'll cover the major topics of this episode, focusing primarily on the New Year traditions of the court—we'll look at the major events of the first month for each year in the reign, allowing us to see some of the similarities, and differences. Finally, we'll look at the last year of Ohoama's reign, particularly as he grew ill, because it can be a fascinating question:  What did people do when disease struck before we had modern medicine?  Here the Chronicles reveal a lot about not only the beliefs of the time, but of their syncretism: how people were willing to reach out to whatever power they could in order to cure disease.  Whether it was Yin-yang divination, beseeching the local kami, or attempting to make merit, all of these things were on the table when it came to illness and mortality. And so, let's get into it. One of the first things I want to talk about is the problem that we have in trying to read the Chronicles, both in the way they are written and then the translation issue on top of that.  Even in Japanese the Chronicles have to be translated out of an ancient form of kanbun—basically a Japanese version of Chinese, using Sinitic characters.  Like any document written by non-native speakers, the Chronicles have their idiosyncrasies that make it different from what someone in Chang'an might be writing at the same time.  There are times and places where it is clear that something is meant to be read in the Japanese pronunciation, which itself was different from modern Japanese.  Add to this the fact that there are many times that different Sinitic characters sound alike in Japanese—especially in modern Japanese.  So any English translation of the Chronicles which doesn't give the actual characters in the source text can add to the confusion.  This is why I like to consult either the Japanese Historical Text Initiative or an electronic version of the National History series text—though even those have issues at times when the characters used in the text don't exist in modern character sets, though that seems to be less and less of a problem. One example I want to give of the complexities of reading the Chronicles, and the need to dive deeper into the original language and consult multiple versions, is a set of records for Ki no Omi no Abemaro and others.  He is our first mention of a member of the Ki family: on the 9th day of the 8th month of 673, the first year since Ohoama's ascension and one year after the Jinshin no Ran, we are told that Ki no Omi no Abemaro and others were given favors and rewards for their service during the war in Iga province.  Indeed, Ki no Omi no Abemaro is listed prominently in the records of the Jinshin no Ran and appears to have been one of the generals for Ohoama and the Yoshino faction in general.  Less than a year later, on the 28th day of the 2nd month, Ki no Omi no Abemaro died and was posthumously awarded the rank of Daishi, which was 5th from the top in the old system of 26 ranks.  A rather respectable rank, to be sure. Later that same year we get a note that Ki no Omi no KATAmaro—another member of the family, apparently--was appointed, along with a "Prince Mino" as a commissioner for the erection of the Great Temple of Takechi. Two years later, however, we get a record on the 22nd day of the 4th month of 676 that the sovereign, Ohoama, sent an order to the Governor of Mino telling him to let the children of Ki no Omi no Abemaro, resident in the district of Toki, be removed to the East country and become peasants in that country.  On the face of it, this appears to be an incredible fall from grace.  Ki no Omi no Abemaro is basically one of the top generals and heroes of the Jinshin no Ran, but his children are so unruly that they are banished to the East and stripped of their noble status?  There has to be a story there, right? Then in 679, on the 3rd day of the 2nd month, we are told that Ki no Omi no Katamaro died.  For his service in the Jinshin War he received the posthumous rank of Upper Daikin.  That would have been roughly the 7th rank—two below Ki no Abemaro.  So was the Ki family back in the good graces of the court?  What is going on? First off, when we go to the original text, we see that Aston, whose translation of the Nihon Shoki we've been working on Ihas made an apparent error in translation.  Remember, Aston was translating the Chronicles back in 1896, without the aid of modern computers, along with a lot of other research that has happened since then, and I can hardly fault him for missing things here and there.  This is why, if you cannot check the original, you may want to also look at the new translation from John Bentley.  Here we can see that he translates the name not as "Ki no Omi no Abemaro", but rather that of "Ki no Omi no KASAmaro".  And if we compare Ki no Omi no KaSAmaro with the previous entry on Ki no Omi no KaTAmaro we can see that these are actually the exact same names except for a single character.  Which leads us to the question:  Are these the same person, and the scribes simply miswrote one of the characters in the name?  It may not even be on the Chroniclers so much as whatever texts they were, themselves, working on.  This isn't helped by the fact that we later on see another entry for Ki no KATAmaro, but that one uses character for "KATA", meaning "hard", using the kun'yomi, or Japanese reading, rather than using two phonetic characters in the on'yomi reading.  So is this just another way to write "KATAmaro" or is this a different person altogether? Ultimately, we cannot be entirely sure.  It does seem wild that there would be two "Ki no Omi no Katamaro" at court at the same time and nobody otherwise distinguished the two.  The question about KaSAmaro and KaTAmaro, and whose kids were sent into exile, is a bit harder to untangle. And, truth be told, it is ultimately a minor point.  We have only a couple of lines here, and maybe these passages will help illuminate something later in the histories, but for now, they are just fragments of the story of what was happening.  Parts of the tattered tapestry from which the royal history was ripped out and restitched together, the rest of the story largely discarded, unless it made its way to us through other means. The Chronicles may be flawed, but they are still our main source for the period, and while we might challenge individual items, we still get a glimpse at how things operated back at this time.  For instance, if we look at the events happening around the New Year, we can see some common threads. The New Year is an important tradition in many cultures.  Whether it was a solar or lunar cycle—or some combination—the new year indicated a new cycle, and was often accompanied by associated symbols and rituals.  Today in the US it is often celebrated with fireworks and champagne, followed by making resolutions for the new year.  In Japan, people will often go to their local shrine or temple for an important first visit, and temple bells will ring out 108 times. Another tradition is the osechi-ryori, the  traditional new years foods.  This has grown over time from a tradition of eating a large bowl of rice to various other foods that are seen as auspicious or having special properties, such as the hardening of teeth—a major concern before the era of modern dental hygiene!  Then there are traditions such as the Kagami Biraki, or opening of the mirror, and the creation of special mochi, or rice cakes for the purpose.  Of course all of these traditions started somewhere and have evolved over time, so what do we know about the New Year celebrations during the late 7th century? One caveat: in the Chronicles, we only really see what was happening in the court, and the Yamato court at that.  There may have been local traditions that others were following that, unless we find documentation about them, we likely would never know.  But many of the court traditions were passed down to later generations. These traditions appear to include the giving of gifts; large, celebratory banquets; and the annual archery tournament. Banquets are some of the first and most common things we see.  We see a banquet as Ohoama assumed the throne in 673—which probably was the event that overshadowed anything else they might have done that year.  The following year, 674, there doesn't seem to have been much recorded, and I wonder if they were still pulling everything together after the turmoil of Ohoama's ascension.  And so it is that in the first month of 675 we really get to see the annual new year's events in their full form.  On the second day of that year, from the Royal Princes on down, all of the public functionaries presented their respects to the sovereign.  I suspect that this was a large ceremony, where everyone gathered in the courtyard of the palace together or something similar, not that each person individually went up and presented their respects—I doubt Ohoama would have wanted to sit through all of that.  Also, as we've already seen, there were limits on what parts of the palace different functionaries were allowed to enter.  So some of these well-wishers may have been "outside", others in the courtyard, and others in the palace building itself, depending on their rank and importance in the bureaucratic hierarchy. On the following day, all public functionaries, from the initial rank upwards, presented firewood.  Aston notes that this is the first mention of what would become a yearly practice.  Firewood may not seem like much, but it would have likely been important to keeping things running, especially given how early people were supposed to arrive at the palace and administrative complex each day.  This wasn't firewood for a fireplace—they didn't have those—but probably would have been used either for cooking or, I suspect, for the large braziers that burned with wood and pitch to light the darkness, particularly in the winter months.  Firewood could also be processed into smaller pieces of coal for other uses.  It is interesting that for the first ceremony, the Chronicles describe the court from the Royal Princes on down, while for the giving of firewood the order is from the initial—which is to say the lowest—ranks upwards.  This could indicate the order in which things progressed in these cases. Several days after that, on the 7th day of the first month, a banquet was given at court for the Ministers—so only the higher ranking functionaries.  But ten days later, on the 17th, everyone of rank—the Ministers of State; the Daibu, or high officials; and all of the public functionaries from the initial rank upwards had an archery meeting in the Court of the Western Gate. Archery and archery contests had been important to the Yamato people for ages—and the same on the continent.  Confucius, in his day, suggested that archery was a martial skill that even nobles should cultivate.  I believe we've noted before how archery could be used both for warfare and for just feeding your family.  As such, it was considered a particularly useful skill for just about everyone to have.  It probably also helped that it was a martial skill that noblemen and others could use to show off without actually risking any injury to themselves in the process.  I'm just saying.  And as we described at the top of the episode, this particular archery contest would, for both participants and spectators, likely have been a chance to show off the top of their game, whether in martial prowess, clothing, or behavior. And since we are looking at the new year's celebrations, let's keep this going and look at later years in Ohoama's reign. As I go through these you'll start to see the patterns, where the events I've just described will generally recur year after year, but not identically, sometimes with a shuffle in the schedule. In 676, we see that the Ministers and public functionaries pay their respects on the first day of the new year.  On the 4th day, the sovereign granted gifts to the higher level officials, from Royal Prince Takechi, down to the high officials, or Daibu, of Shoukin rank.  Their not so secret Santa gifts included robes, hakama, lined garments, obi for their waist, leg straps, and staves, or walking sticks.  We are also told that everyone above the rank of Shoukin also got an armrest thrown in, as well.  Further gifts or grants were given out several days later, on the 7th, to everyone from Shoukin on up, based on their individual circumstances.  Then, on the 15th, we again see all of the functionaries present firewood and then they were all entertained at a court banquet. The following day they held the annual new year's archery contest, with prizes, at the court of the western gate.  Those who hit the target received prizes of different values.  In his recent translation of the Nihon Shoki, Bentley references Kuroita on Article 41 of Miscellaneous Statutes, saying that this archery event was apparently a regular new year's occurrence, and even the prizes were noted as varying over time. The same day they held the archery contest, that year, Ohoama held a banquet at the Shima Palace.  Shima was the name given to the Soga Prime Minister, back in the day, so I assume that this was at or near the site of the old Soga residence? In 677, by comparison, we don't see nearly as much referenced.  There is archery at the South Gate, vice the west gate, but that is it.  The festivities in 678 similarly only talk about the archery at the south gate.  There is also mention of a preparation for worshipping the kami of heaven and earth, for which a purification was held throughout the state.  In addition, an abstinence palace, or saiguu, was erected on the bank of the Kurahashi river.  Kurahashi appears to refer to a tributary of the Ohara river, in Sakurai.  This feels less like a New Year's celebration, however, and more like a sign of merit-making.  The Saiguu would have likely been to prepare for a trip to Ise shrine, and three months later Ohoama was preparing to go to the Saiguu, but that is when Princess Towochi suddenly died, and they scuttled the plans. In 679, the court greeted the New Year with a new decree.  Ohoama declared that Princes, Ministers, and public functionaries—anyone in service to the government, basically, were to refrain from paying respects during New Years or other ceremonies to anyone except relatives of the grade of elder brother, elder sister, and above, or to the senior members of the Houses.  Princes weren't even to pay respects to their own mothers unless they were, themselves, princesses.  Ministers were likewise not to pay respects to their mothers if they were of "mean" rank.  In other words, if they were commoners. These kinds of statutes are interesting.  First of all, you ask yourself why?  In all likelihood, there were various local traditions and individuals paid respects to their parents as well as to others to whom they owed respect for one reason or another.  Here the State is ordering society such that there is a clear hierarchy, at least among the members of the court.   Since women often found advancement by marrying up, it was usual for one's mother to have been born a lower rank in society than oneself.  And so we see them enforcing the social order. That new order was based on Confucian concepts of hierarchy, and this seems to go along with those same ideas. What we don't really see is how this was enforced—if at all.  The day after that, the yearly archery competition took place at the West Gate of the palace. The next year, 680, we see a New Year's Banquet at the Court of the Great Hall.  Ohoama himself occupied the Mukai-kodono, which appears to refer to one of the smaller wings.  Based on the palace layout that we see in the posthole remains, this probably means that he was set up in the smaller wing, likely in a more intimate space, while most of the other guests were in the large hall, maintaining that crucial separation of sovereign and subjects. This New Year's archery event included Princes of the Blood all the way down to the rank of Shouken—the very lowest rank in the court—and it was held at the South Gate. You may be noticing a pattern, that the archery competition is listed as being held at either the south or west gates.  The south gate probably refers to the main gate of the later Okamoto—aka the Kiyomihara—palace.  The West gate refers to the west gate of the Ebinoko enclosure.   We talked about these and the general layout of the palace back in Episode 134, and you can check out that podcast blog post for some images of what things looked like, as well.  These gates were on the north and east sides of a large, rectangular courtyard, which was likely the actual event location.  So it isn't as if these were separate areas, just a difference of where things were set up in what was otherwise the same relative space. The following year, 681, we see similar ceremonies.  We see offerings made to the kami of Heaven and Earth, and we once again see a note about various functionaries paying their respects at court.  Even though this wasn't mentioned every year, it could have been an annual thing and just wasn't always recorded so the Chroniclers just wrote down what they had records for.  There are certainly other things we don't necessarily witness in the records, such as the annual promotions and promulgations.  We see irregular promotions, of course, such as on someone's passing, but the regular administration of the government and promotions of people to new positions is not something we really see regularly documented, since it doesn't really shed much light on the sovereign and the royal household.  And so we sometimes see things if they get mentioned, but otherwise we only see glimpses.  That would change as records became more administrative and the histories were more about simply recording what was happening—though still from a particular angle.  At this point, however, we aren't dealing with a single court record, but rather with numerous records, stories, and recollections.  That same year, 681, we also see another banquet, with Ohoama situated in the Mukai no Kodono, while the Princes of the Blood and non-royal Princes were both introduced into the inner reception chamber.  Ministers attended in the outer reception chamber.  They all received sake and musical performances, and rank advancements were given out.  Kusakabe no Kihi no Ohogata was graduated from the rank of Upper Daisen to Lower Daikin, and given the title of Naniwa no Muraji.  A few days later, Sakahibe no Muraji no Iwazumi was granted a fief with 60 horses and received presents of coarse silk, floss silk, cloth, and one hundred mattocks—the last one being a rather interesting gift, I have to admit.  Of course, in true Chronicles fashion, we have no idea why these gifts were made—we don't even have another reference to Iwazumi around there, but he must have done something. We are later told that there was the annual archery shoot, and then a decree, possibly unrelated to New Years, that the various provinces were ordered to repair the shrines to the kami of heaven and earth. The year 682 is an anomaly.  There is no mention of a banquet, nor of an archery tournament.  I wonder if this may have to do with some of the sad events of that first month.  While it started fine—Toneri no Miyatsuko no Nukamushi was raised from Daisen to Lower Shoukin—we are told that on the 18th, Lady Higami, one of Ohoama's consorts, died in the palace.  The next day there was an earthquake, and she was buried on the 27th.  A prominent illness and death may have put a pall on the ceremonies, and could explain why we don't see any mention of them for that year. It is also possible that some of this New Year tradition had become so routine that people were no longer commenting on it, and therefore the Chroniclers weren't including references to it. The following year, in 683, we again see the functionaries paying their respects.  We also see the presentation of a three legged sparrow by the Viceroy of Tsukushi, Tajihi no Mabito no Shima, along with others.  A three legged sparrow would have been something: it is reminiscent of the three legged crow, often depicted in the sun.  It is unclear if it was still alive, but that wasn't the point.  They invited the Princes of the Blood down to the Ministers to great hall, the Daigokuden, for a banquet, where the three legged sparrow was displayed. .  Later that month, Ohoama issued a decree in regards to all of the auspicious omens and made presents to everyone, from Shouken rank upwards.  There was also a general amnesty—all crimes were pardoned, from capital offenses on down, and all forced labor was remitted, so that people didn't have to provide the normal service.  The phrasing for this particular entry is intriguing.  Ohoama is mentioned as Yamato Neko Sumera no Mikoto and is specifically called a "God Incarnate".  This is one of the rare times that we see the Chronicles explicitly call out the sovereign as a living deity.  Of course, they trace the royal lineage back to Amaterasu, but there isn't a lot suggesting that the sovereign is necessarily a deity. And in reality, this was probably something that was more honorific than anything else.  Heck, at times in Japanese history we would see sovereigns selling their calligraphy to help keep the royal palace funded while warriors went around actually being in charge of things.  However, this divine language did show up in the 19th and 20th century, especially as the Tennou, now called Emperor in English terminology, once again was recognized as the Head of State, and people would actually pray to him.  Not necessarily like praying at a shrine, but out of respect.  And remember, a lot of time the Tennou was kept out of sight of regular people and hidden, much like the way that the kami were treated.  The concept of the Emperor's divinity was very much tied up in the elevation of the State and the general sense of Nationalism that had gripped Japan in the early half of the 20th century.  And so the allies quite explicitly had Emperor Showa renounce his divinity after Japan  World War II. Those studying Japanese history have probably heard of this concept, and so it is interesting to see evidence of it here, as well as the nature of the royal house, where the sovereign is kept at a distance from those of lower rank, unless they are directly serving him.  But it was not as though the sovereign was a god in the sense of being all powerful.  Even if he were considered a living, visible kami, the kami were not omnipotent, and there was no getting over the fact that our particular sovereign, Ohoama, was getting older.  Only a year or so earlier, he had suffered a rather bad illness, so he clearly was not invincible.  And it is of course possible that this language was simply royal exaggeration, rather than any attempt to define the sovereign as something more than he was.  Still, that concept would continue to play a part throughout Japanese history. The same day in 683 that Ohoama issued the pardons, we are told that there was a special performance at the Woharida Court of dance and music from Goguryeo, Baekje, and Silla—the "Three Countries" of the Korean peninsula, even if only one of them was still going strong.  The Woharida palace is thought to have been north, along the banks of the Asuka River.  It may have been moved over time—there appears to have been a palace in the Furumiya area, near Toyoura, but there is also evidence of a palace by a shared name over by Ikazuchi-no-oka, on the other side of the river.  Excavations at Ikazuchi no oka revealed pottery with the name of the palace, suggesting that this was the site, but even then, that pottery was from the later Tempyo era.  Regardless, it seems that the Asuka valley was just chock full of palaces, new and old, though the older ones were not as regularly used for government functions, one assumes. The following year, 684, we again get told about the annual archery shoot.  It took place in the Eastern court this time, with Ministers in attendance.  Apparently they had men skilled in archery shooting alongside palace attendants and little people—the word used in Japanese is "Shuju" or "Hikihito".  This word is often translated as "dwarf"; it appears to be a derogatory term for anyone considered short of stature, though it is also used to refer more generally to those seen as either lacking wit or to actors and performers. This isn't the first time we see the term.  Back in 675, about 9 years prior, Ohoama had sent orders to a number of regions near the capital, from Awaji to Tamba, to Afumi and to Mino and Wohari, among others, to send as tribute common people who could sing, shuju—or dwarfs—and jugglers.  More generally they seem to be referring to entertainers, and it strikes me that could be what is meant here.  Either way, the entertainment industry was hardly a lucrative one, and we can see that performers are almost more of a commodity, to be "paid" as tribute, rather than a professional who is "hired" to work.  I suspect that, as in many other times and places, individuals who were shorter than average often found work as entertainers in this sense—whether they wished it or not. The year 685 we don't see any mention of archery, though it probably still happened.  Instead the Chronicles focus on the various government officials paying their respects to their sovereign.  The rest of the entries for the month are largely concerned with changes to the rank system as of that year. The year 686, we get the last records of various new years festivals—four months later, the sovereign would grow terribly ill, and he would eventually pass away later that year.  However, for those still celebrating the new year in 686, that was all in the future. The last year of Ohoama's reign started out relatively like others. Ohoama went to the Daigokuden, the Great Hall of Audience, and gave a banquet to the Princes and High Officials.  There he decided to have something of a riddle challenge.  He would ask riddles, and then offer prizes for the correct answer. And no, unfortunately we don't have any of the riddles, at least that I have seen.  Aston calls these "conundrums" and notes that they are specifically nonsensical questions, and provides examples such as "Why does a horse, after a rapid run, listen to the earth? Why does a dog, when he goes slowly, raise his leg?"  Ohoama's son, Prince Takechi, answered correctly, and so did Prince Ise.  Their prizes differed in content, but in both cases were pretty extensive.  The winners received ceremonial robes, brocade or purple hakama, numerous bolts of coarse silk, many pounds of thread, hundreds of pounds of flossed Silk, and hundreds of bolts of cloth. I think that makes it quite a bit more lucrative than any of the quiz nights I've ever been to. Later that month, there was another banquet, this time for nine Buddhist monks of Daikan-daiji. Besides its status as a national temple, this may have also been related to the year before, when Ohoama had fallen ill, and prayers had been offered at Daikandaiji for his recovery.  The courthad likewise provided gifts to the temple in the last month of the previous year, and then, at the banquet, gave to the attending monks silk and cloth, based on their rank. But that wasn't the end of the gifts.  The following day the Princes and High Officials all received upper garments and hakama—likely referring to official garments—each getting one suit, each. Then, on the 13th day of the new year, the court invited 20 exceptional individuals to a banquet.  These were talented people, professors, divination specialists, and physicians.  They were also wined and dined and presented various gifts. On the 16th day, the Princes and High Officials were then invited to a banquet in the Daigokuden.  They were given gifts of silk and cloth, based on their rank.  Then they held another riddle competition, with correct answers rewarded with gifts of coarse and flossed silk. This was only a short time after disaster had struck, though a bit removed—two days earlier, in the evening, the royal storehouse at Naniwa had caught fire, eventually burning the entire Toyosaki palace complex to the ground.  Some claimed that it was actually started at a private residence,  that of Ato no Muraji no Kusuri, and then spread to the Palace.  In the end, only the military storehouse was spared. This would have been quite the tragedy for the government, but it did not halt the festivities happening down in Asuka.  The Naniwa Palace appears to have been a major government center for the administration of the state, but it was not the royal court which had been in Asuka for over a decade.  Indeed, I imagine that the news probably reached Asuka around the time of the Banquet itself. And yet, rather than putting a damper on the festivities, they continued another couple of days – presumably everything was already prepared and there was no point in canceling.  On the 17th, the court sponsored a banquet in the rear palace, presumably for the Queen and members of the imperial family.  Then the following day there was a great revel at the palace.  Ohoama took his place in front of the royal muro and made presents to performers, as well as to the singers.  As before everything varied according to rank. Asuka wasn't the only place to get in on the festivities.  The same month, the court also sponsored a banquet for the Silla envoys in Tsukushi, sending Prince Kawachi and others. Regrettably, that would be the last new year that Ohoama would see.  In the fifth month, he grew ill, and what we see in the Chronicles after that is an interesting look into how people of the time dealt with sickness. First, the court had the Sutra of Yakushi expounded at Kawaradera and held a Buddhist retreat in the palace, inviting monks to come and expound Buddhist teachings.  Yakushi, or Yakushi Nyorai—Bhaisajyaguru in Sanskrit—was known as the Medicine Buddha, and his name in Sinitic characters was basically "Master of Medicine".  It is said that he was responsible for the Eastern Pure Land, and that, as a Bodhisattva, he had made 12 great vows to cure the illnesses of all living beings in the world.  For that reason, Yakushi Nyorai was often called upon to cure illness.  In fact, six years earlier, when the Queen, Uno no Sarara Hime, had taken ill, Ohoama erected an entire temple to Yakushi Nyorai, known as Yakushiji.  He then had 100 people take vows as priests, and they attributed her recovery to this effort. In this case, however, it seems that it didn't have quite such an effect, and Ohoama remained under the weather.  We are also told that the court sent Palace Attendants, the Oho-toneri, to clean the pagodas of various temples and that a general amnesty was announced for all under heaven, emptying the prisons.  All of this points to the idea of making merit in the hope of bringing good karma, and thus healing. But the following month, Ohoama was still ill.  Divination was performed by the Onmyoji, the court diviners, and they claimed that there was a curse from Kusanagi, the sword that is considered one of the three main royal symbols.  This is the sword that was said to have been found by Susanowo in the tale of Yamata no Worochi, and which gained its name, Kusanagi, when used by Yamato Takeru, cutting down the grass to save him when his enemies tried to catch him by setting fire to the field where he was hunting.  For more on that, check out Episodes 34 and 35. Given the importance of Kusanagi, I suspect that the idea of destroying it to remove the curse was out of the question, and so it was sent to Atsuta Shrine, where it was enshrined and would largely stay except when needed for enthronement ceremonies.  And yet, even after the sword was taken away, the illness remained.  Six days later, on the 16th day of the 6th month, the court sent Prince Ise and officials to Asukadera and asked the monks there to make and oath with the Buddha to make Ohoama whole through the power of the Three Treasures of Buddhism.   For their work, the three Buddhist Officers, the Master of the Law, and the Upadhyaya and temple directors, as well as those monks with the rank of "master" each received a donation of one robe and one cover, or "Ohi". Three days later, the court ordered the hundred officials to go to Kawaradera and perfom the ceremony of lighting lanterns and giving offerings to Buddha.  Then they held a great feast and offered repentance for their transgressions.  All of this sounds like a continued attempt to make merit for the state, and thus for Ohoama. We then see the court granting the monks Hounin and Gishou 30 stipend-households to provide for them in their old age, which may be more merit-making, or possibly was related to some of the many other activities so far.  There are a few issues with this entry, and Aston and Bentley don't seem to agree on the actual date.  Bentley has it on the 28th, but that seems odd as it comes before the entry for the 22nd of the same month.  Aston has it as the 20th, but then claimes that there is something odd about the date of the 22nd. On the 22nd, we are simply told that the district kitchen of Nabari caught fire.  Aston notes that this would have been the official government arm in the district gathering food to supply the royal household—rather than being a kitchen in terms of a place to prepare food. Merit-making continued into the 7th month.  We see the Soujou and Soudzu, the primary and secondary prelates of the Asukadera, performing ritual repentance.  The following day there is another general amnesty, and Aston specifically mentions performing a Oho-harai, or cleansing. The day after taxes were halved from the provinces and corvee labor with local conscripted labor was exempted for the year.  Then we see the court presenting paper offerings to the Kunikasu Kami in Ki provinces, as well as the four shrines in Asuka and the Great Suminoe—aka Sumiyoshi—shrine. On the 8th day of the 7th month, 100 monks were invited to the court to read the Golden Light Sutra—Konkoymyou kyou.  And on the 15th there was another court issued amnesty. Despite all of these attempts to make merit and intercede with the Buddha or with various kami, Ohoama's illness continued.  We see that the court issued a decree that all things that should occur, great or small, should be reported to the queen and the crown prince—presumably because Ohoama was no longer in a state to be able to do so. Continuing with their efforts, the court declared that destitute commoners who had been forced to borrow rice seed or money before the 12th month of the previous year would be exempted from repayment.  And then the court changed the name of the year to Akami-tori, or Shuuchou.  They also renamed the palace in Asuka to "Kiyomihara"—again, go check Episode 134 for more on the palace.  "Shuuchou" is the Red Bird, likely referring to Suzaku, though Aston also points out that "Asuka" here is given as "flying bird", as well, and there had been numerous bird-related omens reported throughout the reign. Although these names would not have been used prior to this point—the 7th month of the final year of the reign—the Chroniclers applied the nengo, Shuuchou, to all of the entries for this year, and the name of the palace is often given as "Kiyomihara" is given to distinguish it from the Later Okamoto Palace, even though it was simply the latter palace with the addition of the Ebinoko enclosure. The changing of the era name was likely another attempt to change the seemingly inauspicious year, along with all of the merit-making that the court had been undergoing. And yet they kept going. The court selected 70 people who were diligent in keeping Buddhist laws and had them take the tonsure, and they sponsored a feast—or festival—in the Royal Muro of the Palace. At the same time the various princes had a statue of the Boddhisatva of Compassion, Kannon, made for the sovereign and had the Lotus sutra—the sutra where Kannon is first mentioned—read out at Daikandaiji. Kannon, or Avalokitesvara, was originally seen as a male Boddhisatva, but is often depicted as a woman.  They are also known as Guanyin, from which we get Kannon in Japanese.  Guanyin is also seen as Goddess of Mercy, and is one of the most popular figures across multiple sects of Buddhism and even outside of the Buddhist faith, where she is still seen as a goddess.  In this case, however, it seems clear that the princes were seeking compassion to relieve the sovereign of his affliction. And yet it persisted. They had 80 more people take the tonsure, and then 100 more men and women, placed 100 statues of the Boddhisatva, Kannon, in the palace, and then read out 200 volumes of the Lotus Sutra. And then they made prayers to the kami of Heaven and Earth.  And they dispatched Hata no Imiki no Iwakatsu to present paper offerings to the Tosa great shrine.  Nothing seemed to be working. In the 9th month, we see the royal princes and others, down to the various ministers, all gathered at Kawaradera making oaths for the health of the sovereigns.  This last ditch effort would go unrewarded.  Five days later, and Ohoama would pass away.  Of course, they couldn't just say that he died:  The Chronicles actually say that he divinely departed.  After all, didn't they call him an incarnate kami? Two days later, the court began the ritual of mourning, raising voices in lamentation, and setting up a temporary palace of interment in the courtyard, south of the palace.  Ohoama's body was placed there some thirteen days later, and people mourned his passing. For the rituals, we see monks and nuns performing ritual lamentation in the courtyard between 3 and 5 am, around the time that court officials would normally be waiting at the gates.  Over the next several days, various ceremonies were held and eulogies given.  We are told that the court presented offerings of food for the dead for the first time, and over the next several days monks and nuns would offer their laments and then various individuals would provide their eulogies.  Finally, on the last day of the ninth month, the eulogies concluded with Nyang-u, a Baekje prince, who pronounced a eulogy on behalf of his father, and then the Miyatsuko of various provinces came and did likewise.  There were also performances of all manner of singing and dancing. With that, the reign of Ohoama would come to an end.  The government would continue under his wife, the Queen, and Crown Prince.  We'll get into the succession in a later episode.  For now I'll just say that he was eventually buried in a large tomb in the modern Noguchi area of Asuka, and you can still go see it. And while that does bring us to the end of the reign, we still have a few more things that I want to discuss.   This episode just seemed a good time to talk about all of the various new years ceremonies, and that seemed to lead naturally into the very last year, but there is still more to discuss.  For one thing, we still haven't quite covered the spread of Buddhism and the changes in the structure.  There are also various laws and punishments that are worth covering.  Finally, there are the Chronicles themselves: we've talked about it all along, but the Nihon Shoki and the Kojiki are attributed to this era, as is the start of what would become the capital of Fujiwara-kyo—many works that Ohoama would not live to see to the end, but is largely held responsible for starting. But until then, if you like what we are doing, please tell your friends and feel free to rate us wherever you listen to podcasts.  If you feel the need to do more, and want to help us keep this going, we have information about how you can donate on Patreon or through our KoFi site, ko-fi.com/sengokudaimyo, or find the links over at our main website,  SengokuDaimyo.com/Podcast, where we will have some more discussion on topics from this episode. Also, feel free to reach out to our Sengoku Daimyo Facebook page.  You can also email us at the.sengoku.daimyo@gmail.com.  Thank you, also, to Ellen for their work editing the podcast. And that's all for now.  Thank you again, and I'll see you next episode on Sengoku Daimyo's Chronicles of Japan.  

On this episode of Love All, Kim Clijsters joins Blair Henley from Melbourne to break down what's really happening at the Australian Open, from the energy on the grounds to the viral $1 million One Point Slam. Kim gives her expert take on Coco Gauff's evolution against Iga Swiatek, Daniil Medvedev's reset after a coaching change, and Alexander Bublik's breakthrough. They also cover Aryna Sabalenka's title run, Elina Svitolina's win in Auckland, and the biggest storylines heading into the main draw.  Welcome to Love All! We're so happy you're here. If you want to hang out with us behind the scenes and stay close to the heart of the game, follow us on all of our socials: https://www.instagram.com/loveallpodcast/ https://www.tiktok.com/@loveallpodcast https://x.com/loveallpodcast    ⏰ TIMESTAMPS: 0:00 Welcome to Love All0:47 Melbourne weather & the "Happy Slam" vibe4:48 The One Point Slam: Rules, community, and the $1M15:33 Henley's Headlines: United Cup15:47 Coco Gauff vs Iga Świątek: why the tide has turned20:20 Belinda Bencic's great week: Is peaking before a Slam dangerous?24:00 Svitolina's Auckland title26:46 Medvedev wins Brisbane: 22 titles in 22 cities32:45 Bublik wins Hong Kong, Musetti's finals struggles & mental pressure35:10 Memory Lane: Kim's first Australian Open at 1639:26 2004 AO final vs Justine Henin & learning from losses41:55 2011 AO title, comeback as a mom & becoming World No. 143:55 Guest Question: What motivated Kim more: fear of failing or joy of success?45:53 Rec Room: Blair's makeup secret47:22 Kim's rec: The Australian Open app49:00 Closing thoughts & wrap-up Learn more about your ad choices. Visit megaphone.fm/adchoices

#395 - Sponsor Spotlight - RedblockThis episode is sponsored by Redblock. Visit redblock.ai/idac to learn more.Jeff and Jim come to you live from the Gartner IAM Summit in Grapevine, Texas, for a special Sponsor Spotlight with Redblock. They sit down with CEO Indus Khaitan to discuss how Redblock uses AI and computer vision to solve the "last mile" problem in identity management: disconnected applications.Indus explains how Redblock acts as an "agentic" layer, using screen recordings to learn administrative tasks for apps that lack APIs. The conversation covers the origin of the company name, the urgency of securing the "long tail" of applications, and how they build trust and guardrails around AI execution. They also discuss the "DoorDash" analogy for identity fulfillment and wrap up with a fun chat about Indus's passion for flying planes.Connect with Indus: https://www.linkedin.com/in/khaitan/Learn more: redblock.ai/idacConnect with us on LinkedIn:Jim McDonald: https://www.linkedin.com/in/jimmcdonaldpmp/Jeff Steadman: https://www.linkedin.com/in/jeffsteadman/Visit the show on the web at [idacpodcast.com](http://idacpodcast.com)Timestamps00:00 Introduction from Gartner IAM Summit00:46 Guest Introduction: Indus Khaitan of Redblock01:40 Indus's Journey into Identity02:41 The Origin of the Name "Redblock"04:20 The Underserved Market: Services vs. Software07:34 The Urgency of Securing Disconnected Apps09:19 Why Traditional IGA and PAM Aren't Enough11:35 The DoorDash Analogy: Where Redblock Fits14:30 What Makes Redblock Unique? (Agentic Process Automation)16:15 Trusting AI with Security Tasks18:50 Onboarding Apps via Video Recording21:23 Deployment: Running Air-Gapped on Customer Cloud22:17 Handling UI Changes and "Full Self-Driving" Analogy25:40 Integration with SailPoint and Governance Tools27:13 Speed of Integration: Days vs. Years32:00 How the "Headless Browser" Works33:35 Limitations: Web Apps vs. Thick Clients36:58 Redblock's 2025 Milestones and Future Outlook39:48 Call to Action: Solving Disconnected Apps40:27 Impressions of the Gartner IAM Summit44:26 Are We in an AI Bubble?46:46 Indus's Hobby: Flying PlanesKeywordsIDAC, Identity at the Center, Jeff Steadman, Jim McDonald, Redblock, Indus Khaitan, AI, Artificial Intelligence, IAM, Identity and Access Management, Disconnected Apps, Agentic AI, Computer Vision, Gartner IAM Summit, RPA, IGA, Cybersecurity

We're back from break with season 12 of The Body Serve! The off-season didn't let up for a second, with its fair share of surprising breakups: Carlos and Juan Carlos, Naomi and Evolve, and Novak splitting from the players' organization he co-founded. We also cover Potapova's copypasta, Venus' wedding, the ESPN commentary reshuffle, Iga's viewing habits, and more off-season stuff. We look ahead to the coming season with our usual breakout picks – no ADF this time – plus we recap the opening week Down Under, as Bencic leads her team to the final while Poland snatches their first United Cup. 3:25 Alcaraz and Ferrero split 10:35 Naomi Evolves away from the agency she co-founded 15:10 Djokovic quits the PTPA 22:10 Other off-season stuff: Iga didn't watch, ATP rolls out safeguarding program, Next Gen Finals, Venus at the altar!  35:30 Looking ahead: our breakout picks for 2026 45:30 Changes to the ESPN commentary lineup 51:50 United Cup highlights: Hubie, Belinda, Zizou 60:00 Titles for Sabalenka, Svitolina, Medvedev, Bublik 65:35 The podcast landscape

On this episode Fred Goldstein invites Ami Gopalan, Senior Vice President of Strategic Content and Growth Optimization at Precision AQ in a continion of AMCP's rare disease series with an in-depth look at IgA nephropathy (IgAN), a progressive autoimmune kidney disease that often goes undiagnosed until advanced stages. As a patient living with IgAN, Ami brings both a professional and personal perspective to the discussion as we explore the disease's silent progression, the burden it places on patients and families, the evolving treatment landscape, and how managed care can better incorporate patient value, clinical guidelines, and emerging evidence to support long-term outcomes. This podcast is supported by an independent medical education grant from Alexion and AstraZeneca Rare Disease. AMCP offers CPE for this podcast through December 31, 2026. For additional information and to claim credit, please visit: The Power of Partnership: Bridging Patients and Payers in IgA Nephropathy Management. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen

In this episode of the IRH Clinician's Corner, guest host (and IRH lead practitioner) Sara Fields sits down with Dr. Julie Greenberg, a licensed naturopathic doctor and registered herbalist renowned for her root-cause approach to skin and hair disorders. Listeners will hear fresh insights on the vital connections between gut health and skin conditions, uncover the most common root causes behind eczema, acne, and hair loss – and learn why functional medicine offers hope for patients who've felt helpless in conventional care.   In this interview, we discuss:   The foundations of functional dermatology  Common skin conditions in functional practice (how to identify & treat them) Various root causes and disease patterns associated with skin conditions How to use assessment tools and lab testing to enhance results Food, nutrition, and sensitivity considerations  The role of histamines, toxins (like mold/mycotoxins), and autoimmunity in chronic derm conditions Treatment planning and patient/client management The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   Connect with Dr. Julie Greenberg: Website: https://rootcausedermatology.com  Instagram: https://www.instagram.com/dermatologycenter/  Dr. Greenberg is offering $250 off her Root Cause Dermatology course. Enter code RWSlistener to sign up and learn more about this fascinating topic.   Timestamps:  00:00 "Journey to Clean Skincare" 08:33 "Eczema and Acne: Beyond Skin" 14:39 "Gut Patterns in Skin Diseases" 19:15 SIBO, Fungal Overgrowth, Gut Testing 31:22 Healing Gut to Ease Sensitivities 34:35 "Nutrition, Acne, and Underlying Triggers" 46:17 "Functional Medicine Approach to Eczema" 53:55 "Overwhelmed Immune System Analogy" 01:00:45 "Tracking Progress and Healing Time" 01:08:46 Conclusion Speaker bio:    Dr. Julie Greenberg is a licensed Naturopathic Doctor (ND) and Registered Herbalist RH(AHG) specializing in functional dermatology. She is the founder of The Center for Integrative & Naturopathic Dermatology, Inc., a holistic medical clinic dedicated to identifying and treating the root causes of skin and hair disorders. She also founded RootCauseDermatology.com, an educational platform that trains functional medicine practitioners in evidence-based approaches to dermatologic care. Dr. Greenberg holds degrees from Northwestern University (BA), Stanford University (MBA), and Bastyr University (ND). She is the co-author of The Holistic Psoriasis Management and Nutrition Guide, the first comprehensive text on natural approaches to psoriasis treatment. A respected educator and innovator, Dr. Greenberg teaches dermatology at several naturopathic medical schools and lectures internationally. She is a highly sought-after speaker at integrative and functional medicine conferences across the United States and abroad.   Keywords:  functional dermatology, eczema, acne, psoriasis, gut microbiome, leaky gut, stool testing, organic acid test (OAT), GI MAP, food sensitivities, mycotoxin testing, mold exposure, autoimmune skin conditions, histamine, mast cell activation syndrome, skin microbiome, hair loss, alopecia areata, integrative health, naturopathic medicine, chronic skin disease, thyroid health, Hashimoto's, blood sugar dysregulation, dietary fiber, plant-based nutrition, topical steroid withdrawal, allergy testing, hormone testing (Dutch Test), secretory IgA, nutrient deficiencies Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Welcome to HCPLive's 5 Stories in Under 5—your quick, must-know recap of the top 5 healthcare stories from the past week, all in under 5 minutes. Stay informed, stay ahead, and let's dive into the latest updates impacting clinicians and healthcare providers like you!Interested in a more traditional, text rundown? Check out the HCPFive!Top 5 Healthcare Headlines for January 3-10, 2025:Here are one-sentence, clinician-focused summaries with titles restated and no statistics included:1. FDA Approves Caplacizumab-yhdp (Cablivi) as First Pediatric aTTP TherapyThe FDA approved caplacizumab for adolescents with aTTP, making it the first therapy specifically indicated for pediatric patients with this condition.2. Pemvidutide Gets Breakthrough Therapy Designation for MASHThe FDA granted Breakthrough Therapy Designation to pemvidutide for MASH, supporting its accelerated development based on promising mid-stage clinical data and alignment on a registrational phase 3 program.3. FDA Grants Priority Review Of Biologics License Application For Atacicept In IgA NephropathyThe FDA granted Priority Review to the BLA for atacicept, advancing a potential new biologic therapy for adults with IgA nephropathy.4. FDA Approves 2-Gram Presentation of Fibryga for Acquired Fibrinogen DeficiencyThe FDA approved a higher-dose presentation of Fibryga, expanding dosing flexibility for fibrinogen replacement in patients with acquired fibrinogen deficiency.5. FDA Accepts for Priority Review sBLA for Teplizumab for Children With Stage 2 T1DThe FDA accepted a Priority Review sBLA for teplizumab to expand its use to younger children in order to delay progression to clinical type 1 diabetes.

Join Jeff, Jim, and special guest Ian Glazer at the Gartner IAM Summit 2025 as they discuss the Identity and Access Management (IAM) industry, the evolution of IAM practices, and the exciting new concepts like Continuous Identity. They delve into topics such as the impact of AI, shared signals framework, and the struggles and triumphs of identity practitioners. Plus, hear about the Digital Identity Advancement Foundation's mission and enjoy some lighter moments with tales of 'chuckles' and supper clubs. Don't miss this insightful and entertaining episode of the Identity at the Center podcast.Connect with Ian: https://www.linkedin.com/in/iglazer/Connect with us on LinkedIn:Jim McDonald: https://www.linkedin.com/in/jimmcdonaldpmp/Jeff Steadman: https://www.linkedin.com/in/jeffsteadman/Visit the show on the web at http://idacpodcast.comTimestamps00:00 Introduction and Casual Banter00:50 Conference Highlights and Podcast Milestones03:00 Introducing Ian Glazer05:43 Digital Identity Advancement Foundation (DIF)08:09 Challenges in Identity Governance and Administration (IGA)13:28 Continuous Identity: A Paradigm Shift22:31 Real-World Applications and Organizational Impact31:51 Realistic Security Measures32:28 Maturity of Identity and Access Management34:54 Skills and Challenges in IAM36:44 Metrics and Outcomes in IAM40:23 Identity Practitioner Skills41:19 Solving Problems with AI46:21 Continuous Identity and Future Trends48:45 Identity Salon and Community54:19 Wrapping Up and Future EventsKeywordsIan Glazer, Continuous Identity, Shared Signals Framework, CAEP, Gartner IAM Summit, Identity Security, Joiner Mover Leaver, IGA, Access Certification, Identity Salon, IDAC, Identity at the Center, Jeff Steadman, Jim McDonald, IAM, Cybersecurity, Non-Human Identity, Identity Practitioner, DIAF

In this special year-end WTA predictions podcast, tennis analysts Brenner Morton and Carson Nix break down their top 10 predictions for the 2026 WTA season. From the battle for world No.1 to the next generation of rising stars, they analyze the biggest storylines shaping women's tennis.Will Aryna Sabalenka hold onto the No.1 ranking, or can Iga Świątek reclaim the top spot in 2026? What does the future hold for teenage sensation Mirra Andreeva—continued rise to superstardom or a challenging season? Brenner and Carson also discuss Grand Slam contenders, potential breakout players, ranking shake-ups, and bold predictions that could redefine the WTA Tour.Perfect for WTA fans, tennis analysts, and anyone following women's professional tennis, this episode delivers expert insight, sharp debate, and forward-looking analysis ahead of the new season.Topics covered:2026 WTA rankings predictionsSabalenka vs Świątek: the fight for No.1Mirra Andreeva's trajectory in 2026What lies in store for Coco Gauff and Elena Rybakina?Breakout players and potential disappointmentsYear-end WTA storylines and bold forecasts

Experts decode American Society of Nephrology (ASN) 2025 immunoglobulin A (IgA) nephropathy trials: B‑cell therapies, who benefits, and practical steps to improve patient care. Credit available for this activity expires: 12/24/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/navigating-advances-iga-nephropathy-key-developments-2025a100105j?ecd=bdc_podcast_libsyn_mscpedu

30. detsembri õhtul läks Facebookis otse-eetrisse 2,5 tunnine Telegram.ee aastalõpu saade, kus heitsime põgusalt pilgu peale aasta jooksul toimunule ning lõviosa saatest oli pühendatud külalistele, teemaks riigiametite vassimine ja looduse rahaks tegemine ning Rail Balticu tarvis Raplamaale planeeritava Künka IV liivakarjääri peatamine. Põnevatest ja isegi šokeerivatest kokkupuudetest Keskkonnaameti, omavalitsuste ja teise riigiametitega pajatasid looduskaitse ekspert Mati Sepp, MTÜ Meie Nursipalu eestvedaja Maarika Niidumaa ja Hagudi külavanem Piret Laur. Oma panuse saatesse andis kirja teel ka legendaarne geoloog, ühiskonnaaktivist ja Tallinna Tehnikakõrgkooli emeriitprofessor – paevana Rein Einasto.    Künka IV “moneybomb“ Saate käigus kogusime annetusi Terve Eesti Koostöökoda MTÜ kohtuvõitluseks Keskkonnaametiga, mis on vassimise abil läbi surunud kaevandusloa Trev-2 Grupile Künka IV liivakaevanduse rajamiseks Raplamaal. Nagu ütles saates ka Maarika Niidumaa, siis kõik MTÜ Meie Nursipalu kohtuskäigud ja kohtuvõidud oleks olemata, kui inimesed ei oleks seda omalt poolt toetanud. Ka Mati Sepp oli seisukohal, et kui juba kohtusse minna, siis enamasti looduskaitsjad kaotajaks ei jää, sest nagu ka Künka IV kaasuse puhul on näha, siis nii Keskkonnaameti kui ka valla eksimused asjaajamises on ilmselged. Kui 30. detsembri hommikuks oli Terve Eesti Koostöökoda MTÜ kontole laekunud 460 eurot, siis 24 tundi hiljem on sinna lisandunud 236 eurot ning eesmärgist 4200 eurot on puudu veel ca 3500 eurot. Iga euro on oluline, palun toeta, kui sul on võimalik! Suur-suur tänu kõigile toetajatele!!! Vaata siit paljastavat lühidokki “Künka IV: kuidas sünnib keskkonnakuritegu”: terveeesti.ee/   Vaata aastalõpu saadet järgi siit:   Loe live-kommentaare siit: https://www.facebook.com/TelegramEE/videos/753648827756885   Toeta Künka IV liivakarjääri rajamise peatamist! Kuigi Terve Eesti Koostöökoda MTÜ on suure osas materjalist Keskkonnaametile esitatud vaide tarvis juba ise kokku otsinud, on advokaadibüroo EMERALD LEGAL esimene arve ja kohtukulud kokku 3700 eurot + minidokumentaalfilmi montaaž 500 eurot. Meie missiooniks on kaitsta Eesti elanikke õigusi, sh loomariigi ja eluslooduse omi. Keskkonnaamet ei tohi olla kaevandusfirmade lobiorganisatsioon ja esmaseks eesmärgiks on peatada Künka IV liivakarjääri rajamine Mälivere külas, Kohila vallas, Raplamaal. Kuna sarnast mustrit kasutatakse Keskkonnaameti ja kaevandusfirmade poolt ka mujal, siis see puudutab meid kõiki. Koos suudame rohkem! Terve Eesti Koostöökoda MTÜ EE757700771010032203 (LHV) Allkirju ootab ka petitsioon Künka IV liivakarjääri peatamiseks. Kui soovid olla kohtuasjaga kursis, siis jälgi Terve Eesti Koostöökoda MTÜ kodulehte ja liitu uudiskirjaga.   Mati Sepa tegemistega saad olla kursis läbi Facebooki ja tema looduskaitse tööd toetada: Saaja: Mati Sepp Konto: EE532200221030078894 MTÜ Meie Nursipalu ja Maarika Niidumaa tööl saab silma peal hoida Facebookis ja kodulehel, toetada saad: Saaja: MTÜ Meie Nursipalu Annetuskontod: COOP EE164204278627019309 SEB EE231010220296942221 SWED EE262200221081750310 LHV EE417700771009030805 Selgitus: “Juriidilne abi” Telegram.ee tegevust saad toetada näiteks Telegrami tellides. Veel täna keskööni on käimas Telegrami AASTALÕPU KAMPAANIA: telli Telegram 6-kuuks ja saad kingituseks pileti 31. jaanuaril 2026 toimuvale veebiseminarile “Teadvuse deKodeerimine: peaesineja David Icke“! (+ järelvaatamine!). TELLI SIIT!    Toimetas Mariann Joonas   https://www.telegram.ee/eesti/vaata-jargi-aastalopu-otsesaade-kulas-mati-sepp-maarika-niidumaa-jt  

W tym magicznym świątecznym czasie nie chciało nam się przygotowywać do odcinka, więc postawiliśmy na swobodną pogadankę okołoświąteczną i noworoczną. Jedyną osobą, która jako tako cokolwiek zrobiła przed nagraniem jest Iga, która w swoim CJG opowiada obszernie o grze Empires of the Undergrowth. W odcinku brakuje Dominika, bo się pochorował. Ale jak wyzdrowieje to wraca, […]

The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)Sophia Ambruso @sophia-kidney.bsky.socialSwapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)Editing and Show Notes byNayan Arora @captainchloride.bsky.socialThe Kidney Connection written and performed by Tim YauShow NotesProteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)BLISS Belimumab in lupus nephritis (NephJC | PubMed)The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)If you can't get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)Tubular SecretionSwapnil Hiremath Pluribus on Apple TV (Wikipedia)Jon Barratt Lynyrd Skynyrd (Wikipedia) Slow Horses (Wikipedia) on AppleTVJoel Topf the new ASN

Aasta saab kokku võetud kõikide püsipanelistidega kahetunnises erisaates. Iga püsikas valib teistele teadmata loo tänavusest aastast ja räägib, miks just see imponeeris ning teised omakorda hindavad. Aga juttu tuleb paljust muust, mis sel aastal täheldanud ja kuulnud oleme.

In this episode, we break down the WTA Match of the Year 2025 (No.1) — the unforgettable Australian Open semi-final between Madison Keys and Iga Świątek.

This week the gang talked about Fallout TV show, One Piece 3v3, Duskfade, Bullshit Jobs, Good. News:Expedition 33 IGA award rescindedhttps://www.polygon.com/clair-obscur-expedition-33-indie-game-awards-goty-rescinded/DoS 3 will be “next level”https://www.bloomberg.com/news/newsletters/2025-12-16/-baldur-s-gate-3-maker-promises-divinity-will-be-next-level?accessToken=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJzb3VyY2UiOiJTdWJzY3JpYmVyR2lmdGVkQXJ0aWNsZSIsImlhdCI6MTc2NTg5MzY2NSwiZXhwIjoxNzY2NDk4NDY1LCJhcnRpY2xlSWQiOiJUN0Q4ODFLSVAzSTkwMCIsImJjb25uZWN0SWQiOiJCMUVBQkI5NjQ2QUM0REZFQTJBRkI4MjI1MzgyQTJFQSJ9.D26Cs7X_5kH5HuJT2frcX_AMIXyuXWefzz5NK2VlXEI&leadSource=uverify+wall&embedded-checkout=trueLarian on AIhttps://x.com/LarAtLarian/status/2001011042642505833Switch cartridges https://x.com/Nintendeal/status/2001309529339023380Starfieldhttps://www.windowscentral.com/gaming/xbox/is-xboxs-starfield-going-to-get-its-cyberpunk-2-0-moment-rumors-swirl-around-a-secret-event-and-a-ps5-launchVince Zampella Deathhttps://www.nbclosangeles.com/news/local/video-game-developer-vince-zampella-crash-call-of-duty/3819576  Call the show 804-286-0626 Theme song remixed by http://www.Poisonfrog.bandcamp.com

Based on a popular well known Christmas carol this episode reminds us about prescribing thoughtfully, recognising key red flags, and keeping often-missed diagnoses like bile acid diarrhoea, coeliac disease and liver disease on the radar. The episode also reinforces the importance of early-life microbiome influences and structured differential diagnosis for abdominal symptoms in primary care. Prescribing and de-prescribing • Taper PPIs rather than stopping abruptly to avoid rebound acid hypersecretion, driven by upregulated gastrin during PPI therapy. • Always link NSAID use and H. pylori status to ulcer risk, and remember: gastric ulcers typically cause pain with meals, duodenal ulcers 2–3 hours after eating. Diagnosis, tests and red flags • Use three coeliac test “groups”: serology (tTG/EMA, with total IgA checked), genetics (HLA‑DQ2/DQ8) and duodenal biopsies; ensure patients eat gluten for at least six weeks pre‑testing and to endoscopy. • Actively screen for GI red flags: dysphagia and weight loss (upper GI), PR bleeding and unexplained iron‑deficiency anaemia (lower GI), and escalate for urgent investigation. Practical tools and endoscopy indications • Use the Bristol Stool Chart (types 1–7) routinely in consultations to standardise conversations about stool form and avoid ambiguous “food analogies.” • Remember the three main indications for endoscopy: diagnostic (e.g. dyspepsia, chronic diarrhoea), surveillance (Barrett's, polyp follow‑up) and therapeutic (RFA/EMR in Barrett's, polyp removal). Conditions to consider and not miss • Keep bile acid diarrhoea prominent in the differential for IBS‑D: up to ~40% of IBS‑D patients may have it, particularly with ileal disease/resection, Crohn's, or post‑cholecystectomy. • Maintain a broad GI bleeding differential beyond cancer (e.g. gastritis, peptic ulcer, Mallory–Weiss tear, haemorrhoids/fissures, liver disease/coagulopathy, IBD, angiodysplasia, diverticular disease). Liver disease, microbiome and early life • Remember major causes of liver failure in primary care: excess alcohol, paracetamol overdose, DILI, autoimmune hepatitis, Wilson's disease, haemochromatosis, viral hepatitis B/C and progressive MASLD. • Support breastfeeding where possible to promote a healthy infant microbiome (HMOs favouring bifidobacteria) and recognise how birth mode and early microbes shape immune development and later allergy/immune risk. Structuring abdominal symptom assessment • For undifferentiated abdominal symptoms, consciously work through a core list: IBS, lactose intolerance, coeliac disease, gastroenteritis, SIBO, IBD, diverticular disease, colorectal cancer, peptic ulcer disease, gallstones/biliary colic, pancreatic insufficiency and medication‑related causes (e.g. metformin, NSAIDs, antibiotics). • Use these categories to guide targeted history, examination, basic tests and thresholds for referral back to gastroenterology or specialist services. Chapters (00:00:04) - The 12 Days of Gutmas(00:01:04) - PPIs(00:02:19) - How to manage gastric and duodenal ulcers on(00:03:40) - Celiac disease tests 6, Interventions(00:05:33) - GI red flags on Christmas Day(00:07:48) - The main indications for endoscopy(00:09:07) - 7 causes of liver failure on Christmas Day(00:10:17) - Healthy gut microbiome 8 days after Christmas(00:12:03) - Bile acid diarrhea(00:13:52) - 10 causes of abnormal gastrointestinal bleeding(00:15:34) - The microbiome of the body(00:17:55) - 12 causes of abdominal dysrhythmia(00:19:59) - 12 Days of Gutmas

Sel nädalal on saates külas kultuuriloolane Ivar Tröner ning kirjanik ja kirjandusteadlane Rein Veidemann, kellega räägime Toomas Pauli raamatust "Iga raamat avab uue akna". Saadet juhib Maarja Vaino.

Carlos Alcaraz and Juan Carlos Ferrero have officially parted ways after seven years. In this week's Served Five Setter, we break down the split heard 'round the world, including reactions from Toni Nadal and Feliciano Lopez. Is Carlitos ready for the next step without his mentor? Plus, a massive shakeup in Madrid as Garbiñe Muguruza takes charge, the ATP finally adopts a strict Heat Rule for 2025, and Iga Świątek gives back to the next generation in a big way. COMMENT BELOW What was your favorite racket story from this week?

Retrospectiva 2025: Um Ano Épico no Mundo do Tênis!"2025 foi um ano inesquecível para o tênis mundial! Dominado pela rivalidade eletrizante entre Jannik Sinner e Carlos Alcaraz, que dividiram os quatro Grand Slams: Sinner conquistou o Australian Open (defendendo o título) e Wimbledon (seu primeiro na grama), enquanto Alcaraz brilhou no French Open (defendendo com uma virada histórica) e no US Open (seu segundo título em Nova York).No feminino, novos nomes brilharam: Madison Keys finalmente ergueu seu primeiro Major no Australian Open, Coco Gauff dominou o saibro com o título em Roland Garros, Iga Świątek voltou ao topo na grama de Wimbledon, e Aryna Sabalenka fechou o ano com força no US Open.

Join hosts Jeff Steadman and Jim McDonald for a special live episode recorded on location at Identiverse DC! In this interactive session, Jeff and Jim host a game of "Majority Rules," where the audience competes not to answer correctly, but to guess the most popular answer in the room.The game covers a wide range of topics, from the trivial (worst conference swag and the official uniform of an IAM architect) to the technical (securing API keys, the biggest bottlenecks in IGA, and the primary causes of role explosion).Things get intense halfway through with the introduction of the Battle Royale rules, where picking the minority answer sends a player's score back to zero. Watch to see who survives the explosions and takes home the grand prize.Connect with us on LinkedIn:Jim McDonald: https://www.linkedin.com/in/jimmcdonaldpmp/Jeff Steadman: https://www.linkedin.com/in/jeffsteadman/Visit the show on the web at http://idacpodcast.comChapter Timestamps00:00 Intro to Identity at the Center Live00:36 Explaining the Rules of Majority Rules04:25 Question 1: The Worst Conference Swag06:00 Question 2: Replying to Access Denied07:05 Question 3: AI in Identity Management08:40 Question 4: Favorite MFA Method10:12 Question 5: Least Favorite Auth Factor11:15 Turning up the Heat: Battle Royale Mode12:10 Question 6: Why RBAC is Difficult at Scale13:30 Question 7: The IAM Architect Uniform14:50 Question 8: Best Place to Hide a Secret16:15 Question 9: Protocols You Secretly Miss17:25 Question 10: Most Hated Specialized Key18:40 Question 11: Conference Responsibilities20:00 Question 12: Securing API Keys21:20 Question 13: Secrets to Surviving Keynotes22:55 Question 14: The Biggest Bottleneck in IGA24:45 Question 15: Causes of Role Explosion25:50 Question 16: What Breaks First After a Schema Update26:40 Final Question: Fastest Way to Confuse a User27:40 Crowning the WinnerKeywordsIDAC, Identity at the Center, Jeff Steadman, Jim McDonald, Identiverse, Identiverse DC, IAM, Identity and Access Management, Cybersecurity, InfoSec Game Show, Live Podcast, Majority Rules, MFA, IGA, API Security, RBAC, Role Explosion, Tech Humor, Cyberrisk Alliance

Après deux saisons à New York dans la LPHF, Jade Downy Landry revient à Montréal. Cette fois, elle n'affronte plus la foule : elle jouera pour elle. Dans cet épisode du balado Isa, Femme de sports, présenté par IGA, Jade se livre avec franchise sur :L'émotion forte de porter le chandail de la Victoire de Mtl devant les siensSa vision du succès et la manière dont elle veut contribuer à l'équipeUne anecdote marquante qui donne à réfléchir sur la santé des athlètes fémininesCe qui nourrit sa passion et pourquoi investir dans le sport féminin est essentielEt évidemment, on termine avec mes fameux Tirs de barrage : rires, spontanéité, confession et petits plaisirs assumés.Si tu aimes le hockey, les histoires vraies et les athlètes qui osent se dépasser… cet épisode est pour toi

Uus saade aga seekord on mul külas mitu aastat tagasi pildist ära kadunud selgeltnägija Andrues Vana. Andrues on selgeltnägija ja spirituaalne õpetaja, kes räägib sellest, kuidas meie maailm tehtud on ja mis reeglid siin kehtivad. Kuidas nende reeglitega arvestades ise oma maailma ja tulevikku luua. Ta räägib sellest, kuidas seda elamise asja nii teha, et see oleks kerge ja lihtne. Andrues on kirjutanud ka väga mitu raamatut, millest viimasest "Kahe maailma vahel" selles saates ka räägime. Tema raamatuid ja teisi olemasolevaid tooteid ja teenuseid saad piiluda Fienta leheküljelt: https://fienta.com/et/o/5487 Kui soovid tema uut ja viimast raamatut, siis kasuta koodi "KALA" ja saad raamatuga tasuta kaasa tema loodud kursuse. https://fienta.com/et/emom-143959 --- Mina olen Andruesiga salvestanud varasemalt 8 episoodi, mida on kuuldatud ligikaudu 50 000 korda, neid saad järele kuulata siit: NR.1 - https://soundcloud.com/chris-kala-podcast/andrues-vana-selgeltnagija-102 NR.2 - https://soundcloud.com/chris-kala-podcast/146-selgeltnagija-andrues-vana-vol2-see-mida-sa-tahad-ei-ole-vastus-vaid-hea-tunne NR.3 - https://soundcloud.com/chris-kala-podcast/149-selgeltnagija-ja-spirituaalne-opetaja-andrues-vana-lihtne-elu-osa-i NR.4 - https://soundcloud.com/chris-kala-podcast/152-selgeltnagija-ja-spirituaalne-opetaja-andrues-vana-lihtne-elu-osa-ii NR.5 - https://soundcloud.com/chris-kala-podcast/154-selgeltnagija-ja-spirituaalne-opetaja-andrues-vana-lihtne-elu-osa-iii NR.6 - https://soundcloud.com/chris-kala-podcast/andrues-vana-vol4 NR.7 - https://soundcloud.com/chris-kala-podcast/andrues-vana-vol5 NR.8 - https://www.youtube.com/watch?v=81AQhzv52gA --- PODCASTI SPONSORID MILLION MINDSET KIRJASTUS – Kasuta sooduskoodi “chriskala”

In this 2025 Season Recap, Andy Roddick, Jon Wertheim, and Producer Mike dig into their “winners and unforced errors” of the tennis season: from successful US Open mixed doubles exhibition to the much-criticized extended Masters 1000 events. They debate the sport's failure to empower creators and players to use match footage, and the power struggle over prize money and revenue share at the Grand Slams. The crew also relives Sinner–Alcaraz's unforgettable Roland Garros epic, Coco Gauff's and Iga Świątek's seasons, Sabalenka's resilience, and the booming depth of American tennis on both tours. Finally, they zoom out to why tennis is “having a massive moment” globally and why that makes the structural mistakes and missed opportunities even more frustrating. COMMENT BELOW What was your biggest “winner” and “unforced error” of the 2025 tennis season?

Susan Diane Wolff Cappel was a 19‑year‑old woman from Newcomerstown, Ohio, who mysteriously disappeared on March 16, 1982. She was last seen leaving her job at the local IGA grocery store, where witnesses reported her speaking briefly with the driver of an older model, light blue car before getting inside. She has never been seen again. If you have any information about why Susan went missing or who was responsible for her disappearance, please call the Tuscarawas County Sheriff's Office @ 330-339-2000 or the Newcomerstown Police Department @ 740-498-6161. ⁠Click here⁠ to join our Patreon.  ⁠Click here⁠ to get your own Inhuman merch.  Connect with us on ⁠Instagram⁠ and join our ⁠Facebook group⁠.  To submit listener stories or case suggestions, and to see all sources for this episode: ⁠https://www.inhumanpodcast.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

W dzisiejszym magazynie sportowym: Polacy Mistrzami Świata drużyn 6 - osobowych w piłce nożnej; plany organizacji letniej olimpiady w 2040 roku w Polsce; Iga Świątek i Klaudia Zwolińska nominowane w konkursie na najlepszą sportsmenkę 2025 roku.

We are celebrating your Chaotic Christmas moments thanks to IGA, Poppy had a few hiccups getting registered as being born and Little Wins of the Week!See omnystudio.com/listener for privacy information.

You've worked on some of the most iconic consumer-loved brands—how do you translate that big-brand thinking into IGA's decentralized, independent retail model?How has your direct marketing mindset influenced the way IGA approaches shopper insights, loyalty programs, and CRM in today's fragmented retail environment?What role does storytelling play in building richer customer relationships across IGA's network of stores, especially when trying to drive both local and national relevance?With so much focus on digital innovation and shopper experience, how is IGA evolving its in-store programs to align with online expectations and behaviors?From your experience, what's the most overlooked opportunity for brand and shopper marketing leaders to create more profitable customer relationships in today's CPG-retail ecosystem?

What if the key to calming autoimmunity isn't stronger suppression, but a clearer conversation between your gut and your immune system?In this episode, we sit down with integrative and functional medicine nutritionist Vanessa Vanderhoek to explore how microbiome shifts, barrier breakdown, and nervous system stress converge into autoimmune flares,  and how the GI-MAP can transform complexity into a clear, safe plan. We unpack the clinical significance of dysbiosis patterns such as Klebsiella and Prevotella, the risks signalled by depleted keystone species like Faecalibacterium prausnitzii, and what these patterns reveal about conditions including rheumatoid arthritis, lupus, MS, and juvenile arthritis. You'll learn how to interpret zonulin for leaky gut, use secretory IgA highs and lows as action points, and rely on calprotectin and occult blood as decisive markers for medical referral.Vanessa brings the science to life with real cases: an ulcerative colitis patient who avoided bowel resection by making one well-timed dietary shift; a rare and painful skin condition that settled once triggers were removed and the mucosa repaired; and a case of severe bloating that revealed the early clues of scleroderma, guiding faster diagnosis and a clear path forward. Throughout, we highlight the principles of precision and pacing, building plans that align with a client's readiness, capacity, and budget so meaningful change actually sticks.We also address the often-overlooked driver: vagus nerve dysfunction and chronic stress. When the sympathetic system takes over, digestion stalls, sIgA drops, and tolerance erodes. Vanessa walks us through the simple rituals that restore regulation, sitting to eat, slower chewing, pre-meal breathing, and the nutrients that rebuild the mucosal barrier, including vitamins A, D and E, and zinc. Safety threads through the entire conversation: co-managing with GPs, repeating calprotectin when indicated, and cross-checking protocols with immunosuppressant medications.If you're looking for fewer flares, shorter recovery times, and more agency in autoimmune care, this episode gives you a grounded, clinically relevant roadmap. Subscribe, share with a practitioner friend, and let us know your biggest takeaway.Connect Vanessa:Vanessa's podcast Thrive Forward: https://podcasts.apple.com/au/podcast/the-thrive-forward-podcast/id1806055391 YoutubeShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

In this transformative episode, I sit down with my own teacher and mentor, Dr. Karen Parker, to explore the fascinating world of Quantum Human Design and how our stories literally shape our biology. Dr. Parker is a pioneer who studied with the founder of traditional Human Design and has taken the system to its next evolution—helping people not just understand who they're not, but consciously create who they want to become.  What You'll Discover  Understanding Quantum Human Design  The difference between traditional Human Design and Quantum Human Design  How Human Design synthesizes Eastern and Western astrology, the Chinese I Ching, Hindu chakra system, and Judaic Kabbalah  Why getting back into your body is essential for authentic decision-making  The evolution from learning "who you're not" to consciously creating "who you choose to become"  The Biology of Our Stories  How victim-based narratives actually lower immune response (IgA levels)  The physiological changes that occur when you reframe your story  Why optimists live longer and have longer telomeres  The connection between storytelling and post-traumatic growth  Moving Beyond Survival  Why defining ourselves as "survivors" keeps us stuck at a minimal baseline  The danger of stopping your story at the cliffhanger  How to move from surviving to thriving through the redemption arc  The Stage 3 trap: how repeating our betrayal story keeps us stuck  The Story Lab Process  A creative, fun approach to rewriting your narrative (yes, it can be enjoyable!)  Using creative writing to bypass logic and reasoning patterns  Why taking your story "out of time" creates powerful shifts  Real-life example: How one woman transformed from victim to empowered protector  Key Takeaways  Your story creates your identity, and your identity calls in experiences that validate it. Breaking this cycle requires conscious narrative reframing.  Healing doesn't have to be a crisis. The Story Lab process proves that transformation can actually be creative, playful, and fun.  Check in with your body. After sharing your betrayal story, does your body feel light, open, and expansive? Or heavy and contracted? Your body knows the truth.  The power of the redemption arc. Your story doesn't end at the betrayal—that's just the catalyst. The real story is what happens next and who you become.  Powerful Exercise to Try  Draw a horizontal line across a piece of paper. The left represents your birth, the right represents where you are now. Mark all the significant experiences in your life along this timeline. Then ask yourself: "Did I stop my story at the cliffhanger, or have I defined myself by what happened next?"  If you're still hanging at the cliffhanger, you deserve better than that.  About Dr. Karen Parker  Dr. Karen Parker holds a PhD in transpersonal psychology and is the creator of Quantum Human Design. She studied directly with the founder of traditional Human Design and spent three years in a Sound Lab testing the frequency of vocabulary to create an entirely new system that helps people consciously write their sovereign story. She's also the author of multiple books, including Quantum Wellness, which walks readers through the Story Lab process.  Connect with Dr. Karen Parker  Website: QuantumHumanDesign.com  Instagram & Facebook: @DrKarenParker22  Book: Quantum Wellness (available at major online retailers)  Stay in Touch  The PBT Institute: https://thepbtinstitute.com   My Personal Connection  As a 4/6 Manifesting Generator (Time Bender) myself, studying with Dr. Karen was life-changing. Learning about the triphasic life cycle of the 4/6 profile helped me understand why my life crashed and burned at exactly age 50—and why that was actually the beginning of my true purpose work. The concept of "finding shortcuts" as a Manifesting Generator perfectly explains why the five stages of Post Betrayal Transformation showed up in my research—it was THE shortcut to healing! 

On this episode, host Fred Goldstein invites Dr. Kartik Kalra, Clinical Nephrologist at Geisinger Medical Center. We discuss IgA nephropathy and the newly released, comprehensive 2025 KDIGO guidelines. We explore what IgAN is, why diagnosis is often delayed, how it commonly presents, and the impact the disease can have over a patient's lifetime. Dr. Kalra also discusses what prompted the latest guideline revision, how thinking around IgAN has evolved, and what these changes signal for clinicians, health systems, and the managed care community. This podcast is supported by an independent medical education grant from Calliditas Therapeutics. AMCP offers CPE for this podcast through December 31, 2026. For additional information and to claim credit, please use the instructions provided here: ⁠AMCP Learn - claim CPE instructions https://amcplearn.org/sites/default/files/media/2024-10/AMCP%20Learn%20-%20Claim%20CPE%20Instructions_0.pdf Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen/

Celiac disease affects between one and two percent of Canadians, yet many patients wait years before receiving a clear diagnosis. On this episode of the CMAJ Podcast, the hosts speak with two contributors to the CMAJ review article Diagnosis and management of celiac disease about the condition's diverse clinical presentations, appropriate testing strategies, and the practical realities of long-term dietary management.Jedid-Jah Blom, a registered dietitian at the McMaster Celiac Disease Clinic and researcher at the Farncombe Family Digestive Health Research Unit at McMaster University, shares her own experience being diagnosed and living with celiac. She explains how patients must identify hidden gluten sources in ingredients like dextrin and malt, and why cornmeal or corn flour products may be contaminated. Blom outlines the risks of cross-contamination and dining out challenges, emphasizing whole gluten-free grains over processed products that lack fortification.Dr. Maria Ines Pinto-Sánchez, a gastroenterologist at Hamilton Health Sciences and director of the Celiac Clinic at McMaster University, explains why celiac is called a chameleon disease. She notes that about 30 percent of patients present with gastrointestinal symptoms, while others may have brain fog, fatigue, or anemia. She describes how TTG antibodies plus total IgA are used for screening, with positive results requiring endoscopy and biopsies for confirmation. Dr. Pinto-Sánchez emphasizes that patients should not start a gluten-free diet before testing. She discusses ongoing monitoring including TTG levels, bone density, and nutrient deficiencies.For physicians, the discussion highlights the need for a low threshold when testing TTG antibodies in patients with unexplained fatigue, brain fog, or gastrointestinal symptoms. Both guests stress the importance of completing diagnostic testing before patients begin a gluten-free diet and arranging early dietitian referral.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)Sophia Ambruso @sophia-kidney.bsky.socialSwapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)Editing and Show Notes byNayan Arora @captainchloride.bsky.socialThe Kidney Connection written and performed by Tim YauShow NotesProteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)Updated here (PubMed | NephJC discussion)A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)BLISS Belimumab in lupus nephritis (NephJC | PubMed) The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)Christos' Bluesky post:https://bsky.app/profile/christosargyrop.bsky.social/post/3m5bsujwg3s2q The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)If you can't get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)Tubular SecretionSwapnil Hiremath Pluribus on Apple TV (Wikipedia)Jon Barratt Lynyrd Skynyrd (Wikipedia) Slow Horses (Wikipedia) on AppleTVJoel Topf the new ASN

Send us a textGood morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve deep into a series of transformative events that underscore the dynamic nature of our industry, where scientific innovation meets regulatory evolution and market adaptation.We begin with significant regulatory news from Medicare, which recently announced price reductions for 15 prescription drugs, including Novo Nordisk's semaglutide products, Ozempic and Wegovy. This initiative is part of the Inflation Reduction Act aimed at making essential medications more affordable. By potentially increasing accessibility to these treatments, this move highlights a growing trend towards cost containment in drug pricing within the U.S. healthcare system. It reflects a broader effort to ensure that life-saving treatments remain within reach for more patients, emphasizing the need for balance between innovation and affordability.Turning to approvals, Otsuka has secured FDA clearance for Voyxact, a first-in-class treatment targeting IgA nephropathy (IgAN). This positions Otsuka in an increasingly competitive market space populated by major players like Novartis and Vertex. The entry of Voyxact could pave the way for innovative therapeutics in kidney diseases, offering new hope to patients who have had limited treatment options until now.On the other side of the Atlantic, French authorities have conducted a raid on Sanofi's headquarters as part of a tax fraud investigation. This development sheds light on ongoing scrutiny in the pharmaceutical sector regarding financial practices and regulatory compliance. Such investigations can have far-reaching implications on corporate governance and transparency, reminding us of the importance of ethical practices in maintaining industry trust.Novo Nordisk has strategically used its FDA national priority voucher to expedite the review process for a high-dose formulation of Wegovy. This move underscores the importance of regulatory incentives in accelerating drug development timelines, allowing for quicker patient access to potentially life-changing therapies. It's a testament to how strategic navigation through regulatory pathways can significantly impact drug availability.In clinical trials, Sarepta Therapeutics received FDA clearance to conduct a study combining its gene therapy Elevidys with sirolimus in patients with Duchenne muscular dystrophy. The study aims to address liver safety issues associated with Elevidys, which had led to previous label restrictions. This reflects the industry's commitment to enhancing therapeutic safety profiles while expanding treatment indications.In oncology advancements, AstraZeneca's Imfinzi received FDA approval for use in early-stage stomach cancer, marking its third perioperative indication. This approval underscores the expanding role of immunotherapy across various cancer types and stages, offering new treatment paradigms that could improve surgical outcomes and long-term patient survival.Despite these advances, there is skepticism regarding artificial intelligence's role in regulatory compliance submissions among pharmaceutical professionals. A survey reveals that 65% express distrust towards AI-generated outputs, highlighting challenges that AI technologies face in gaining acceptance within highly regulated environments such as pharmaceuticals. However, federal recommendations to revamp U.S. biotechnology research emphasize incorporating AI into scientific processes to maintain global competitiveness. This call reflects concerns over potential declines in innovation leadership and underscores the need for strategic investment in research infrastructure.In antitrust news, the Federal Trade Commission (FTC) outlined its case agaiSupport the show

In this powerful episode of Diary of a Kidney Warrior Podcast, Dee sits down with Louise, a kidney warrior whose journey with IgA nephropathy spans over 30 years – from diagnosis in her early 20s, to pregnancy complications and heartbreaking baby loss, to finally receiving her life-changing kidney transplant, lovingly named “Katie the Kidney.”   Louise shares how her kidney disease was first discovered during pregnancy, the devastating loss of her son, and how for decades she coped by “putting everything in a box” and carrying on with life. She talks about living abroad with only 22% kidney function, unknowingly walking 20K with undiagnosed angina, and why kidney disease can be such a silent condition.   In an emotional and hope-filled conversation, Louise describes the moment she received “the call” for transplant, watching her donor kidney arrive in a cooler from Edinburgh, and being wheeled to theatre with Katie the Kidney on the end of her bed. She also opens up about the emotional healing that came with kidney failure – exploring trapped emotions, trauma, faith, and learning to truly take responsibility for her health and wellbeing.   If you're newly diagnosed, living with chronic kidney disease (CKD), resisting the idea of dialysis or transplant, or struggling emotionally with your diagnosis, this episode will give you hope, validation and practical encouragement.   In this episode, we discuss: •Louise's first signs of kidney disease and IgA nephropathy diagnosis •Pregnancy, kidney disease and the loss of her baby son •Living 30+ years with CKD and feeling “fine” at 22% kidney function •Discovering angina during transplant workup •Getting the call and meeting “Katie the Kidney” •How transplant changed her energy, skin, and brain fog •The emotional side of kidney disease: grief, trauma, “putting it in a box” •Why acknowledging your diagnosis and caring for your mental health is essential •Louise's advice for anyone newly diagnosed or scared of dialysis / transplant   You are not alone. Kidney disease is not the end – it's part of your story, not your identity.    

Who Killed Sarah Pryor? I want to thank a listener for suggesting this story. I have done episodes on the case of Molly Bish and Holly Pirrainen, and the listener suggested I look into the case of Sarah Pryor. Another case connected loosely to the Pryor case is that of 16-year-old Cathy Malcolmson. Cathy was working at the IGA supermarket when she was abducted on her way home from work. The listener, who is from the Massachusetts area where these abductions took place, said there had been some talk that Sarah's case may also be connected to Molly and Holly's cases. I decided to look into the Pryor mystery and was surprised by what I found. One of the similarities I began to see was the area's geography and how close these incidents took place to one another. Sarah was taken an hour from where Holly went missing, but all three of these cases occurred just off the Massachusetts Turnpike. It may be a stretch to think these cases could be connected, but it doesn't mean the idea should be discounted. Some books and documentaries talk about how the construction of the interstate enabled a new type of killer. Sources: ⁠Bella English⁠ ⁠Boston Globe⁠ ⁠Southcoasttoday.com⁠ ⁠Eileen Prose- YouTube⁠ ⁠Metro West Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is sponsored by Nexis. Visit nexis-secure.com/idac to learn more.In this sponsored episode of *Identity at the Center*, host Jim McDonald sits down with Dr. Heiko Klarl, CEO of Nexis, to explore how the company is advancing authorization governance for modern enterprises. Dr. Klarl explains how Nexis builds visibility and control across fragmented identity landscapes and why “better together” is the right strategy for enterprises with multiple IAM systems.They discuss the emerging Identity Visibility and Intelligence Platform (IVIP) category, the value of automation and remediation in governance, Nexis's unique “health check” service, and their ISPM capability that helps clients identify unnecessary access—and even save on software licensing.Learn how Nexis integrates with IGA and PAM tools, streamlines application onboarding, and helps customers measure the real business impact of their identity programs.Connect with Heiko: https://www.linkedin.com/in/heiko-klarl/More about Nexis: https://nexis-secure.com/idacConnect with us on LinkedIn:Jim McDonald: https://www.linkedin.com/in/jimmcdonaldpmp/Jeff Steadman: https://www.linkedin.com/in/jeffsteadman/Visit the show on the web at idacpodcast.comChapters00:00 Introduction and Sponsor Message00:42 Meet Dr. Heiko Klarl, CEO of Nexis01:29 Dr. Klarl's Journey into Identity and Access Management03:09 What Does Nexis Do?05:00 Challenges in Authorization Governance06:43 The Importance of Visibility in Identity Systems08:23 Nexis' Role in Enhancing Existing IAM Investments10:05 The Concept of IVIP and Its Relevance21:48 Nexis Platform Capabilities23:24 The Health Check: A Deep Dive27:22 Understanding Health Check Costs28:27 Exploring ISPM and License Management32:09 How Nexis Integrates with IGA Systems34:11 Application Onboarding and Compliance36:38 Measuring Value and Success with Nexis43:10 Global Reach and Market Focus45:02 Connecting at Conferences46:49 Visiting Germany: Recommendations and Insights50:17 Final Thoughts and ResourcesKeywordsIDAC, Identity at the Center, Jim McDonald, Jeff Steadman, Dr. Heiko Klarl, Nexis, Nexis Secure, NEXIS 4, authorization governance, role mining, role management, IGA, IAM, IVIP, Identity Visibility and Intelligence Platform, access certification, remediation automation, health check, ISPM, Identity Security Posture Management, license management, enterprise identity, compliance, visibility, identity governance, access review, Gartner IAM, EIC, KuppingerCole

In this episode of Tea with Dr D, host James Q. Del Rosso, DO, is joined by Christopher Bunick, MD, PhD, and later Lisa Swanson, MD, for a deep look at phosphodiesterase-4 (PDE4) inhibition in dermatology, with a special focus on topical roflumilast.  Dr Bunick opens with a primer on the science of PDE4, an enzyme that degrades cyclic AMP (cAMP), an intracellular messenger that regulates anti-inflammatory pathways. In conditions such as atopic dermatitis (AD) and psoriasis, overactive PDE4 leads to reduced cAMP and amplified inflammation. By “gumming up” PDE4, roflumilast restores a more balanced, anti-inflammatory state.  He explains why PDE4 inhibition is relevant across multiple inflammatory pathways, including Th1, Th2, and Th17, and why roflumilast has demonstrated stronger efficacy than earlier inhibitors like crisaborole. Molecularly, roflumilast mimics cyclic AMP's binding to PDE4 across 3 key sites, producing far tighter binding than apremilast and crisaborole, which translates to superior clinical potency.  Dr Bunick illustrates this with a case of palmoplantar pustular psoriasis that cleared dramatically within 8 weeks on topical roflumilast after multiple biologic and corticosteroid failures, highlighting its durability and barrier-restoring properties. He and Dr Del Rosso contrast this with the limitations of chronic steroid use, noting that roflumilast supports long-term control without barrier compromise.  The discussion also touches on vitiligo, where Dr Bunick shares an early case of repigmentation following roflumilast treatment, suggesting possible cAMP-mediated stimulation of melanogenesis. They highlight the molecule's innovative aqueous-based formulation, optimized for skin-compatible pH and excellent tolerability.  In Part 2, Dr Swanson joins to discuss pediatric use. She reviews the 0.15% cream for AD in patients ≥6 years and the 0.05% cream for ages 2–5, both once-daily, steroid-free options that minimize burning and stinging compared with earlier PDE4 inhibitors. They review clinical data that demonstrate rapid itch relief, strong efficacy across IGA and EASI end points, and sustained control with twice-weekly maintenance.  Tune in to hear how PDE4 inhibition, and particularly topical roflumilast, is redefining nonsteroidal therapy across age groups and disease states in dermatology. 

What if adult acne isn't hormonal after all, but an inflammatory signal from the gut asking for help?In this thought-provoking episode, naturopath Asha Evertsz unpacks the gut–skin–brain axis and reveals why most adult acne is less about hormones and more about systemic inflammation, microbial imbalance, and stress. Drawing on years of clinical experience treating complex female acne, Asha reframes the condition as a terrain issue, not a topical one, where digestion, bile flow, and microbial diversity determine how the skin behaves.You'll hear how chronic stress, impaired digestion, and microbiome disruption from antibiotics, the pill, and Roaccutane alter immune pathways and ignite the mTOR signalling cascade that fuels breakouts. Asha walks through the stool markers that matter, including secretory IgA, zonulin, SCFAs, and Akkermansia, and explains the overlooked roles of bile, stomach acid, and pancreatic enzymes, her “guardians of the gut.” She demystifies the H. pylori connection, showing how low stomach acid and disrupted FOXO1 and IGF-1 pathways link directly to acne through poor absorption, excess sebum, and inflammation.From there, we get practical. Asha outlines her phased gut-repair framework: fortifying mucosal defences, feeding the microbiome with fibre and polyphenols, introducing strain-specific probiotics, and only then layering in antimicrobials like berberine, a clever mTOR modulator. She shares clinical pearls on using bovine immunoglobulins to rebuild IgA and barrier function, timing omega-3s once bile flow is restored, and using zeolite, curcumin, and green tea to bind and calm the system during detox. From the outside in, she explains how corneotherapy protects the skin's acid mantle and microbiome with topical pre-, pro-, and postbiotics, ditching harsh actives that create “leaky skin.”Whether you're a practitioner ready to move beyond surface-level acne care or a clinician refining your gut-first protocols, this conversation offers a test-led roadmap for rebuilding both inner and outer barriers, turning chronic flare-ups into calm, resilient skin.Connect with Asha: Acne Naturopath | Asha Evertsz | HomeShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

In this powerful Kidney Warrior Story, host Dee sits down with Tony to unpack a decade-spanning journey through chronic kidney disease (CKD)—from a shock Stage 4 diagnosis of IgA Nephropathy (IgAN) to Stage 5 kidney failure, peritoneal dialysis (PD) with brutal drain pain, a transition to haemodialysis (HD), line infection and coma, the courage to self-needle with a fistula, and ultimately the life-changing gift of a kidney transplant.   Tony shares the practical and emotional realities few hear about: choosing PD vs HD, APD (overnight machine) vs manual gravity bags, buttonhole vs rope-ladder needling, home haemodialysis training, fluid management, and rebuilding confidence after hospital trauma. He explains how movement and sport (from 5K Parkruns to half marathons) helped his mental health on dialysis—and how he kept going after FIVE “dry-run” transplant calls before finally receiving his match.   Post-transplant, Tony competed at the Transplant Games (bronze in cycling!), then faced a sudden cycling accident with a broken talus—and still came back stronger with kidney function over 90%. Tony's message? You're not alone. With support, information, and small, consistent steps, more is possible than you think.   WHAT YOU'LL HEAR • Early signs missed: high blood pressure and “white coat” assumptions  • Stage 4 to Stage 5 CKD: understanding IgA Nephropathy and next steps  • Peritoneal Dialysis (PD): APD vs gravity bags, real talk on drain pain  • Haemodialysis (HD): line infection → coma, then fistula and self-needling  • Buttonhole vs rope-ladder: how Tony overcame needle phobia  • Home HD routine + exercising safely on dialysis (5K to half marathons)  • Five transplant calls that didn't happen—coping tools that helped  • The call that changed everything: consent, surgery, waking the kidney  • Transplant Games success—and recovery after a serious cycling crash  • Mental health: therapy, peer groups, and why talking saves lives  • Practical tips: fluid limits, pacing activity, and building back slowly  • Community resources: Kidney Care UK, young adult kidney groups   KEY TAKEAWAYS • Movement is medicine—start with what you can manage (even 100 metres).  • Your effort matters—even when decline happens, you may be delaying harm.  • Build your circle: family, peers, clinicians, therapists, Kidney Care UK.  • Advocacy counts: read clinic posters, join groups, ask questions.  • Mindset + support = progress. Small daily actions add up.   If you're newly diagnosed or supporting someone with CKD, browse our back catalogue for in-depth episodes on PD, HD, transplant prep, and mental health.   Follow Diary of a Kidney Warrior:  

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into some of the most significant shifts and strategies shaping our industry.Novartis's acquisition of Avidity Biosciences for a staggering $12 billion marks a pivotal moment in the pharmaceutical landscape this year. With this acquisition, Novartis underscores its commitment to bolstering its neuromuscular disease pipeline. Avidity Biosciences has made a name for itself with its cutting-edge RNA therapeutic technologies, particularly its Antibody Oligonucleotide Conjugates (AOCs). This platform uniquely combines monoclonal antibodies with oligonucleotides, enhancing precision in targeting specific cell types. The integration of Avidity's technology into Novartis's research efforts could accelerate the development of new therapies, potentially transforming patient care with more effective and targeted treatment options. This move not only highlights the industry's focus on specialized therapeutic areas but also anticipates future advances in RNA therapeutics, extending beyond neuromuscular disorders to areas like oncology.In a similar vein, the FDA has shown its willingness to reconsider drugs that previously faced setbacks. GSK's Blenrep has made a return to the U.S. market after receiving approval for treating certain myeloma patients. This approval is particularly noteworthy given the drug's earlier negative advisory committee vote and postponed decision. It marks a significant rebound for GSK's oncology portfolio and reflects the FDA's dynamic approach towards drugs that show potential in specific therapeutic combinations.Meanwhile, Sanofi continues to make waves with Dupixent, achieving over €4 billion in quarterly sales due to its expanded indications. This success contrasts with a decline in Sanofi's vaccine sales, demonstrating shifting dynamics within pharmaceutical portfolios where biologics and specialty drugs are increasingly pivotal. Sanofi's recent financial report highlighted a notable 17% drop in vaccine sales due to reduced demand and pricing challenges in Europe. In response, companies must navigate fluctuating public health demands and economic pressures effectively.On the global stage, efforts to make transformative therapies like Vertex's Trikafta more accessible are gaining momentum through innovative trade-policy workarounds. A buyers club aims to introduce a lower-cost alternative produced by Bangladesh's Beximco, highlighting ongoing challenges and creative strategies in global drug accessibility.Roche's expansion through Chugai's $200 million M&A deal for an IgA nephropathy asset underscores the strategic importance of regional markets in driving growth. Similarly, Lonza's acquisition of a California biologics site aligns with its goals to meet increasing biomanufacturing demands.The industry is also adapting to technological advancements, with AI integration into life sciences commercialization being touted as a frontier for growth. Despite this potential, many organizations remain unprepared to harness AI fully. Leading companies embedding AI solutions aim for measurable outcomes that could significantly drive strategic decision-making and operational efficiencies.Eli Lilly's acquisition of Adverum Biotechnologies aligns with its strategic interests in gene therapy, focusing on promising therapeutic programs that address unmet medical needs. This acquisition centers around Ixo-vec for wet age-related macular degeneration (AMD), highlighting broader industry trends towards investing heavily in innovative therapies that address unmet needs.Conversely, Sanofi's halt on an RSV vaccine development highlights the inherent risks in vaccine development pipelines. Meanwhile, Regeneron's decision to discontinue a CAR T candidate acquired from 2seventy bio showcases ongoing reassessment witSupport the show

Welcome to HCPLive's 5 Stories in Under 5—your quick, must-know recap of the top 5 healthcare stories from the past week, all in under 5 minutes. Stay informed, stay ahead, and let's dive into the latest updates impacting clinicians and healthcare providers like you! Interested in a more traditional, text rundown? Check out the HCPFive! Top 5 Healthcare Headlines for October 12-18, 2025: 1. FDA Accepts Inhaled Insulin (Afrezza) sBLA for Pediatric Diabetes The FDA accepted MannKind's sBLA for Afrezza inhaled insulin to expand its use to children and adolescents with type 1 or type 2 diabetes. 2. FDA Approves Updated Indication for Upadacitinib (Rinvoq) in IBD The FDA broadened upadacitinib's indication to allow use in ulcerative colitis and Crohn disease when tumor necrosis factor blockers are not clinically appropriate. 3. FDA Clears First Blood Test to Rule Out Alzheimer-Related Amyloid Pathology The FDA cleared Elecsys pTau181 as the first blood test to help rule out Alzheimer-related amyloid pathology in older adults with cognitive symptoms. 4. Digital Therapeutic Reduces Negative Symptoms of Schizophrenia in Phase 3 Trial A phase 3 study showed a prescription digital therapeutic significantly reduced negative symptoms in schizophrenia when used alongside antipsychotic therapy. 5. APPLAUSE-IgAN: Iptacopan (Fabhalta) Meets eGFR Decline Primary Endpoint Iptacopan demonstrated meaningful efficacy in slowing kidney function decline in adults with IgA nephropathy, supporting future regulatory submissions.

Inflammation is the biological fire underlying most chronic disease. In this episode, Dr. Ritamarie Loscalzo returns with NEPT graduates Steph Jackson and Jennifer Whitmire to uncover how food fuels or fights inflammation.From autoimmune flares and brain fog to hidden cardiovascular risks, the trio explores how everyday foods, even so-called “healthy” ones, can lead to inflammation, and what to do about it. This episode will shift how you look at food, labs, and healing.What's Inside This Episode?How inflammation silently hides in autoimmune conditions, heart disease, and brain fogThe tests most practitioners miss when screening for inflammationWhy food “sensitivities” go far beyond IgA or IgG testingThe hidden downside of health foodsWhy ginger may be as powerful as turmeric and how both interact with the microbiomeHow oxytocin, hydration, and color diversity can be more anti-inflammatory than supplementsResources and Links:Download our FREE Functional Food GuideJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportReserve your spot for ReInvent 2025 here for a deep dive into the impact of the microbiome on brain health including lab testing and geneticsVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing resultsCheck out other podcast episodes hereGuest Resources and LinksSteph JacksonJoin the Friendly Flora Collective – Microbiome MembershipJennifer WhitmireJoin the Culinary Healing CircleGuest BioSteph JacksonIf you are ready to go deep with your digestive health and you need more than slippery elm, you will enjoy working with Nutritional Endocrinology coach, Steph Jackson. Steph loves customizing balancing programs for the micro biome, working with fermented foods, and looking at how the body systems work together. After finding and clearing the root cause of her severe physical pain and exhaustion, Steph has gone on to help others to do the same. She is also the proud founder of Crave Conscious, a non-dairy yogurt company based in Vancouver, British Columbia.Jennifer Whitmire On a mission to save body parts, Jennifer Whitmire is a culinary coach, health educator, and master herbalist specializing in autoimmune and thyroid health. Since 2017, she's taught women how to heal with food by restoring energy, balancing hormones, and repairing the gut through science-backed, whole food plant-based cooking and kitchen-based strategies.

Wojciech Fibak — przez lata dżentelmen polskiego sportu, symbol klasy, elegancji i sukcesu. Triumfator turniejów ATP, półfinalista Wimbledonu, reprezentant Polski w Pucharze Davisa. Kolekcjoner sztuki, biznesmen, człowiek salonów, który obracał się wśród elit — od Donalda Trumpa po czołowych artystów: De Niro, Hugh Grant, Mick Jagger. Ale za tą perfekcyjnie skrojoną fasadą kryje się historia, która podzieliła opinię publiczną. Głośny skandal opisany przez „Wprost”, zarzuty o międzynarodowe pośrednictwo w kontaktach z luksusowymi dziewczynami, to moralne dylematy, których echo słychać do dziś. Fibak, choć nigdy nie przyznał się do winy, do dziś mierzy się z cieniem tamtych publikacji. Jak sam dziś odnosi się do tych afer?  Co myśli o współczesnym świecie sportu i o tym, że Iga Świątek „nie daje się lubić”? Czy miliony, które stracił na produkcji „Psów” Pasikowskiego, były ceną za pasję, czy błędem człowieka, który zawsze grał va banque? Jakie były najdroższe obrazy, w które zainwestował? Dlaczego sprzedaje swój dom w Paryżu?  #płatnawspółpraca

Paul is joined by the first member of the Ball Boy Development Program, tennis fanatic and hair deity Benjamin Kersten, to talk the ins and outs of the Asian swing of the ATP and WTA tours.  We give some love to Iga and Coco for their recent form on and off the court, have some ideas for how to get butts in the seats at the China Open, and try to solve the mystery of Jannik Sinner's tummy.  And in Cross Court we have the case of Cup Sighs, to figure out how to make the schedule just a little bit less insane.  

In this episode, we explore the evolving role of surrogate endpoints in the management of IgA nephropathy (IgAN), with a particular focus on the significance of estimated glomerular filtration rate (eGFR). Of the completed Phase 3 trials in IgAN, one used time-weighted average eGFR, an area under the curve-based measure that reflects the average change in eGFR from baseline over a specified period, in this case, over the full 2-year study period. The other trial used total eGFR slope to describe the overall rate of change over 2 years. But what do these endpoints mean outside the setting of a clinical trial? Expert insights shed light on how proteinuria and eGFR trends can inform prognosis and guide treatment decisions in clinical practice over the long term. Listeners will gain a deeper understanding of how to interpret eGFR changes over time and apply this knowledge to optimize patient care. Designed for nephrology professionals, this episode offers practical, evidence-based perspectives on integrating these surrogate endpoints into the care of patients with IgAN. Supported by Calliditas Therapeutics Upon completion of the podcast, please take a moment to complete a brief survey: https://kidneyforms.tfaforms.net/4728109

Immune discusses the potential future of delivering vaccines by flossing your teeth and how antibodies in human milk shape the normal immune responses in newborns.  Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Floss-based vaccination (Nat Biomed Engineering 2025) Press article on Floss-based vaccine paper (Sci News) Human milk IgA promotes immune development (PNAS 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.