Podcasts about IGM

Hace más de un siglo, se descubrió que podíamos defendernos de las infecciones usando anticuerpos, unas proteínas que fabrica nuestro cuerpo. Al principio, se usaban sueros de animales, como caballos, para curar enfermedades. Hoy, la ciencia ha creado anticuerpos súper precisos, como los monoclonales. Un grupo de científicos ha ido más allá y ha diseñado un nuevo tipo de anticuerpo, una “super IgM”, que actúa como una súper araña con patas muy fuertes para unirse a los agentes infecciosos. Al aplicarlo en un spray nasal, protegió a ratones contra la gripe. En el futuro, podría ayudarnos a prevenir muchas infecciones respiratorias sin necesidad de vacunas tradicionales.

Hace más de un siglo, se descubrió que podíamos defendernos de las infecciones usando anticuerpos, unas proteínas que fabrica nuestro cuerpo. Al principio, se usaban sueros de animales, como caballos, para curar enfermedades. Hoy, la ciencia ha creado anticuerpos súper precisos, como los monoclonales. Un grupo de científicos ha ido más allá y ha diseñado un nuevo tipo de anticuerpo, una “super IgM”, que actúa como una súper araña con patas muy fuertes para unirse a los agentes infecciosos. Al aplicarlo en un spray nasal, protegió a ratones contra la gripe. En el futuro, podría ayudarnos a prevenir muchas infecciones respiratorias sin necesidad de vacunas tradicionales.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.The White House has announced a new drug pricing policy that includes the revival of the most favored nations rule and extends to the private markets, leveraging the patent system, drug importation, and more. Meanwhile, Lilly's Zepbound has been found to have a superior benefit-risk ratio compared to Novo's Wegovy, BMS and Sanofi settle a Plavix lawsuit with Hawaii for $700 million, and biopharma companies are focusing on developing a cure for HIV as federal funding for related research is being cut. Sino Biological offers comprehensive solutions for autoimmune diseases, and Roche promises a $300 million investment in China production after a multibillion-dollar investment in the US. On the other hand, Lexeo and IGM have both announced significant layoffs. Novartis CEO has expressed concerns about Trump's pricing controls.Funding for HIV-related research and infrastructure is being cut by the Trump administration, leading biopharma companies like Gilead and Immunocore to focus on finding a cure for HIV. In the field of neurology, there is a need for more precise diagnostic tools to effectively treat neurodegenerative conditions. The new HHS vaccine requirement has been criticized by leading vaccine physician Paul Offit as potentially being anti-vaccine activism disguised as policy. Companies like Novartis, Bayer, and AstraZeneca are exploring new indications and innovations in radiopharmaceuticals, hoping to capitalize on a market that could reach $16 billion by 2033. The FDA has faced delays in reviewing certain drugs, while biotech stocks have fallen after the appointment of Vinay Prasad to succeed Marks at CBER. Vertex has decided to abandon AAV in the gene therapy space.Upcoming events include a webinar on surviving and thriving in the biotech downturn. Job opportunities in the biopharma industry include positions at Takeda, Daiichi Sankyo, and AbbVie. Heather McKenzie, senior editor at BioSpace, is open to suggestions for future coverage topics in neuroscience, oncology, cell & gene therapy, metabolic, or other areas.

Episode 190: Measles BasicsFuture Dr. Kapur explained the basics of measles, including the pathophysiology, diagnosis and management of this disease. Dr. Schlaerth added information about SPPE and told interesting stories of measles. Dr. Arreaza explained some statistics and histed the episode.  Written by Ashna Kapur MS4 Ross University School of Medicine. Comments by Katherine Schlaerth, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction.According to the CDC, as of April 24, 2025, a total of 884 confirmed measles cases were reported by 30 states, including California, and notably Texas. This is already three times more cases than 2024. There are 3 confirmed deaths so far in the US. What is measles?Measles is a disease that's been around for centuries, nearly eradicated, yet still lingers in parts of the world due to declining vaccination rates. Let's refresh our knowledge about its epidemiology, clinical features, diagnosis, management, and most importantly — prevention.Definition.Measles, also known as rubeola, is an acute viral respiratory illness caused by the measles virus. It's a single-stranded, negative-sense RNA virus belonging to the Paramyxoviridae family. It's extremely contagious with a transmission rate of up to 90% among non-immune individuals when exposed to an infected person.EpidemiologyBefore the introduction of the measles vaccine in 1963, nearly every child got measles by the time they were 15 years old. With the introduction of vaccination, cases and deaths caused by measles significantly declined. For example, in 2018, over 140,000 deaths were reported in the whole world, mostly among children under the age of 5.Measles is still a common disease in many countries, including in Europe, the Middle East, Asia, and Africa. Measles outbreaks have been reported recently in the UK, Israel, India, Thailand, Vietnam, Japan, Ukraine, the Philippines, and more recently in the US. So, let's take prevention seriously to avoid the spread of this disease here at home and abroad. How do we get measles, Ashna?Mode of Transmission:● Air: Spread primarily through respiratory droplets.● Surfaces: The virus remains viable on surfaces or in the air for up to 2 hours. (so, if a person with measles was in a room and you enter the same room within 2 hours, you may still get measles)● Other people: Patients are contagious from 4 days before until 4 days after the rash appears.PathophysiologyThe measles virus first infects the respiratory epithelium, replicates, and then disseminates to the lymphatic system.It leads to transient but profound immunosuppression, which is why secondary infections are common. It affects the skin, respiratory tract, and sometimes the brain, leading to complications like pneumonia or encephalitis.Clinical PresentationThe classic presentation of measles can be remembered in three C's:● Cough● Coryza (runny nose)● ConjunctivitisCourse of Disease (3 Phases):1. Prodromal Phase (2-4 days)○ High fever (can peak at 104°F or 40°C)○ The 3 C's○ Koplik spots: Small white lesions on the buccal mucosa.2. Exanthem Phase○ Maculopapular rash begins on the face (especially around the hairline), then spreads from head to toe. The rash typically combines into 1 big mass as it spreads, and the fever often persists during the rash.3. Recovery Phase○ Rash fades in the same order it appeared.○ Patients remain at risk for complications during and after rash resolution.Complications:● Pneumonia (most common cause of death in children)● Otitis media (most common overall complication)● Encephalitis (can lead to permanent neurologic sequelae)● Subacute sclerosing panencephalitis (SSPE): A rare, fatal, degenerative CNS disease that can occur years after measles infection.High-risk groups for severe disease include:● Infants and young children● Pregnant women● Immunocompromised individualsDiagnosisClinical diagnosis is sufficient if classic symptoms are present, especially in outbreak settings.Ashna: Laboratory confirmation:● Measles-specific IgM antibodies detected by serology.● RT-PCR from nasopharyngeal, throat, or urine samples.Notify public health authorities immediately upon suspicion or diagnosis of measles to limit spread. ManagementThere is no specific antiviral treatment for measles. Management is supportive:● Hydration (by mouth and only IV in case of severe dehydration)● Antipyretics (e.g., acetaminophen) for fever● Oxygen if hypoxicVitamin A supplementation:● Recommended for all children with acute measles, particularly in areas with high vitamin A deficiency. It has shown to reduce morbidity and mortality.Hospitalization may be necessary for:● Severe respiratory compromise● Dehydration● Neurologic complicationsPrevention: We live in perilous times and vaccination is under scrutiny right now. Before the measles vaccine, about 48,000 people were hospitalized and 400–500 people died in the United States every year. Measles was declared eradicated in the US in 2000, but the vaccination coverage is no longer 95%. How do we prevent measles?Vaccination is the cornerstone of prevention.● MMR vaccine (Measles, Mumps, Rubella):○ First dose at 12-15 months of age.○ Second dose at 4-6 years of age.○ 97% effective after 2 doses.The Advisory Committee on Immunization Practices (ACIP) has noted that febrile seizures typically occur 7 to 12 days after vaccination with MMR, with an estimated incidence of 3.3 to 8.7 per 10,000 doses. The Centers for Disease Control and Prevention (CDC) states that febrile seizures following MMR vaccination are rare and not associated with any long-term effects. The risk of febrile seizures is higher when the MMR vaccine is administered as part of the combined MMRV (measles, mumps, rubella, and varicella) vaccine compared to the MMR vaccine alone.Post-exposure prophylaxis:● MMR vaccine within 72 hours of exposure (if possible).● Immunoglobulin within 6 days for high-risk individuals (e.g., infants, pregnant women, immunocompromised).Herd immunity requires at least 95% vaccination coverage to prevent outbreaks.Key Takeaways● Measles is a highly contagious viral illness that can lead to severe complications.● Diagnosis is often clinical, but lab confirmation helps with public health tracking.● Treatment is mainly supportive, with Vitamin A playing a critical role in reducing complications.● Vaccination remains the most effective tool to eliminate measles worldwide.While measles might seem like a disease of the past, it can make a dangerous comeback without continued vigilance and vaccination efforts.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Centers for Disease Control and Prevention (CDC). Measles (Rubeola), Clinical Overview, July 15, 2024. Accessed on May 1, 2025. https://www.cdc.gov/measles/hcp/clinical-overview/index.html.World Health Organization (WHO). Measles, November 14, 2024. https://www.who.int/news-room/fact-sheets/detail/measlesGans, Hayley and Yvonne A. Maldonado, Measles: Clinical manifestations, diagnosis, treatment, and prevention, UpToDate, January 15, 2025. Accessed on May 1, 2025. https://www.uptodate.com/contents/measles-clinical-manifestations-diagnosis-treatment-and-preventionTheme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Esto es HistoCast. No es Esparta pero casi. Nos toca hablar de una persona extraordinaria, Rodrigo Saavedra, Marques de Villalobar, que tuvo un papel fundamental en la I Guerra Mundial. Por ello tenemos con nosotros a dos descendientes suyos Diego Saavedra Silvela e Isabel Saavedra Silvela, acompañados por @cerveranavas y @goyix_salduero.Presentación de IsabelSecciones Historia: - La España del siglo XIX y el comienzo del reinado de Alfonso XIII - 11:00 - Las alianzas anteriores a la IGM y los intereses nacionales en juego - 26:18 - El comienzo de la IG y la neutralidad española - 33:25 - El marqués de Villalobar y su carrera diplomática hasta la IGM - 36:00 - Las batallas de la IGM en Bélgica y sus colonias - 48:02 - El sufrimiento de la población civil en Bélgica - 1:35:55 - El tándem Rodrigo Saavedra y Brand Whitlock y la habilidad de Villalobar con las autoridades alemanas - 1:41:15 - Villalobar como protector del Commssion for Relief in Belgium - 1:49:22 - Intervenciones de Villalobar y de como salvador y actor protagonista de la Oficina Pro Cautivos de Alfonso XIII - 2:10:50 - La ayuda de Villalobar a Adolphe Max, el alcalde de Bruselas, y el cardenal Mercier - 2:23:18 - Villalobar intenta salvar a Edith Cavell, intercede por otras personalidades y para poner fin a las deportaciones forzosas - 2:34:39 - Villalobar y sus esfuerzos por la paz y el orden frente al vacío de poder al final de la guerra - 2:58:00 - Homenajes a Villalobar y a la labor de España al final de la IGM - 3:08:40 - La discapacidad del marqués de Villalobar desde su nacimiento - 3:12:10 - El final de la vida del marqués de Villalobar - 3:26:56 - Entrevista a don Alberto Antón Cortés, embajador de España en Bélgica sobre la memoria de Rodrigo Saavedra - 3:31:00 - La ayuda del hijo de Rodrigo Saavedra cuando el ejército alemán llego a Bruselas durante la IIGM, la historia se repite - 4:07:10 - Entrevista a Carlos Saavedra, presidente de la fundación Rodrigo Saavedra, que ayuda a las personas con problemas de movilidad - 4:28:47 - Bibliografía - 4:39:10

Los pequeños productores guatemaltecos de café sufren una serie de amenazas que les impide seguir cultivando y teniendo ganancias favorables para su comunidad con la siembra y venta de este codiciado oro negro. En la última década todo ha sido cuesta arriba para poder seguir exportando y trasladando el conocimiento a nuevas generaciones de cafetaleros porque los jóvenes prefieren emigrar a Estados Unidos. “Yo preferiría tener un negocio porque la agricultura te salva la vida, te da de comer y todo eso, pero a veces necesitamos dinero también”, explica el joven Pedro Guzmán desde Nebaj, Quiché, en el noroccidente de Guatemala, a seis horas de ruta de la capital.El camino nos lleva a un lugar prestigiado por su ubicación y microclima ideal para la siembra del café, una región de cafetaleros desde hace décadas. Los pequeños productores en esta región han sabido aprovechar y producir algunas de las variedades más destacadas y populares del mundo. Según la Organización Internacional del Café, Guatemala está entre los más destacados de América Central y ocupa el décimo puesto a nivel mundial, además de Costa Rica y Honduras.Pedro Guzmán considera que las oportunidades siguen siendo escasas en su pueblo y aunque no lo tiene muy claro, se plantea emigrar a Estados Unidos, como muchos jóvenes de la región, incluyendo sus primos. ‘Yo sí me alegro de que mis primos que están en Estados Unidos ahora ya tengan sus casas, nosotros aquí vamos superando la situación poco a poco, pero al menos estamos en nuestro país”, reconoce Pedro, que a sus 17 años tiene una peluquería en Nebaj pero le genera pocos ingresos y las exigencias generacionales con sus padres y sociedad son muy fuertes, nos dice.Sin relevo generacional La emigración masiva de jóvenes hacia el norte está provocando un nuevo problema en el campo guatemalteco: no hay relevo generacional y esto pone en peligro la exportación del café. Este producto, tan codiciado, intenta sobrevivir a esta crisis que nunca antes había vivido.”Algunos ya tienen hijos en Estados Unidos, así que los productores prefieren recibir las remesas fáciles y abandonan el café. Actualmente, de los 977 productores que tenemos, el rango de edad supera los 50 años”, asegura Romualdo Pérez, gerente de la Asociación Chajulense, del noroccidente del país, en Chajul, Quiché, a 45 minutos de Nebaj, una de las zonas más afectadas por este fenómeno de deserción.Los compradores de café guatemalteco están presionando a los productores para que promuevan el relevo generacional y así mantener la producción, pero según los pequeños productores, la mayoría prefiere irse a EE.UU. que seguir cultivando café con su familia.“Lo que nos está afectando a nosotros es que no tenemos gente para cortar el café desde hace cinco o seis años, hay muchas personas que se están movilizando”, explica Pedro Caba de 52 años, cultivador de café y presidente de la Junta directiva Chajulense.Considera que el alza del precio del café no es culpa de los productores, ni del comprador, sino de la migración.Desde el 31 de enero hasta diciembre del 2024, 54.056 mil jóvenes en edades comprendidas entre los 19 y los 35 años han sido retornados procedentes de Estados Unidos y México.De enero a febrero del 2025, casi 3.000 jóvenes han regresado engrilletados de manos y pies, según información del Instituto Guatemalteco de Migración.Estados Unidos endurece las leyes, pero los jóvenes no se resignan a a quedarseAunque las leyes estadounidenses sean cada vez más rigurosas contra los inmigrantes, los jóvenes sin opciones siguen arriesgando su vida para llegar a Estados Unidos. Abandonan el país, como lo hicieron sus padres. Consideran que ahora es su turno de irse y mandar dinero a sus padres o familias.“Yo creo que a la mayoría de la gente ya no le interesa la agricultura. En esta área creo que más del 70% han emigrado a diferentes países y lo único que ha traído es la construcción de enormes casas y la agricultura ya se está quedando abandonada”, denuncia Genaro Simalaj, agricultor de Sololá que empezó a trabajar la tierra a los cinco años sembrando maíz y frijol. Romualdo Pérez, de la Asociación Chajulense, cuenta que los jóvenes que consiguen llega a Estados Unidos logran obtener algunas cosas materiales, pero si su estadía fue muy rápida y son deportados, regresan endeudados y sin terrenos para sembrar, así que de igual forma tienen que seguir trabajando para subsistir en Guatemala. El fenómeno también afecta a menores.El Instituto Guatemalteco de Migración (IGM) asegura que desde enero del 2024 hasta octubre del mismo año retornaron a Guatemala vía aérea y terrestre 21.757 mil menores en edades de 14 a 18 años, provenientes de Estados Unidos y México.Una crisis que se compara a la de la royaLos problemas financieros y crisis de la organización se comparan con la que se vivió en el 2012 y la llegada de la roya, una enfermedad fúngica que se caracteriza por la aparición de hinchazones rojizas o naranjas en las hojas y tallos de las plantas. Una especie de hongos parásitos que necesitan plantas vivas para sobrevivir.“Cuando vino el problema de la roya, los productores perdieron casi el 100% de la cosecha durante dos o tres años. En el 2011, logramos exportar 48 contenedores de café, pero ya en el 2012, cuando empezó la roya, de 48 bajamos a 28 contenedores, al tercer año después de la roya, bajamos a 11 contenedores”, recuerda Romualdo Pérez de la Asociación Chajulense. “Cuando la gente vio estas bajas en la producción, su única opción fue emigrar”, agrega.Actualmente, la Asociación Chajulense está pagando 1.300 quetzales (unos 170 dólares) por un quintal 100 Kg de café, pero eso no compensa a los agricultores para mantener a sus familias y la producción anual porque la mayoría son muy pequeños, algunos generan cinco quintales, otros diez y otros 20.La experiencia estadounidense puede convertirse en una pesadilla En los últimos años existen grupos de estafadores que engañan a los agricultores ofreciéndoles visas de trabajo para hacer mayores ganancias y pagos mucho más atractivos si van a trabajar la tierra a Estados Unidos, pero al llegar al lugar se encuentran en fincas, hacinados, con poca alimentación, en climas extremos y al final no les pagan lo prometido, lo cual les obliga regresar sin dinero con muchos traumas por la forma en que son explotados.“Todo el mundo debe enterarse de cómo los jóvenes viven en estas fincas, maltratados y engañados. Yo fui por necesidad, pero estoy arrepentido, sufrí. Al ver que no pagaban, decidí organizar a los jóvenes para que nos dieran nuestro dinero y al final nos regresamos con deudas”, no explica Edgar Ixcaya, un agricultor del occidente de San Marcos la Laguna, Atitlán.Los departamentos desde donde viaja la mayor cantidad de menores no acompañados, en su mayoría indígenas, son de Huehuetenango, San Marcos y Quiché, según el Instituto Guatemalteco de Migración.Sin embargo, existen miembros de la asociación Chajulense que promueven e incentivan a sus hijos a seguir con la compra de terreno en Guatemala para sembrar café, es el caso de Daniel Carrillo de 56 años, es de los socios más antiguos.“Yo les enseñé a sembrar café y cardamomo, ahora ya tienen su plantación, ya les di sus herencias y siguen sembrando”, explica. Carrillo que motiva a otros jóvenes, a pesar de las dificultades, a que trabajen sus tierras y sigan comprando más terrenos.“Este muchacho lleva como tres años trabajando conmigo, quiso emigrar también, pero yo le he dicho que no, que trabaje aquí, porque allá no es fácil, y aquí nos quedamos sin gente”, deplora.La importancia de invertir en tierras desde EE.UU.En su aldea los jóvenes siguen viajando a Estados Unidos. En ese caso, los incentiva para que aprovechen el tiempo y que realicen el viaje con metas claras. Y si vuelven, tendrán un pedazo de tierra para sembrar para sobrevivir. “Yo siempre les he dicho que, si se van a ir, pues no tirarse a los vicios, sino que compren terrenos y luego regresen a trabajarlos”, aconseja Carrillo.Daniel cuenta que muchos jóvenes no regresan porque logran adaptarse a un sistema bastante difícil, pero prefieren eso a volver a su tierra y dedicarse a la agricultura. Incluso él mismo intentó viajar cuando era joven, pero fue deportado. Su hijo, sin embargo, logró irse, a pesar de que Daniel intentó impedírselo.“Le dije que era muy duro el camino, que ahí lo tratan como se le dé la gana a uno y ¿qué tal si no llegas? “, le preguntó. Pero su hijo no tiró la toalla. “Gracias a Dios pues a él sí le fue bien, a los diez días que él salió de aquí ya estaba en migración, él tenía 23 años, pero lo bajamos a 17.  Gracias a Dios la migración no se dio cuenta”, confiesa.Su hijo ya lleva tres años viviendo en Estados Unidos y no quiere regresar, pero Carillo no pierde la esperanza de que su hijo regrese algún día para seguir cultivando café.

In this episode, we detail the role of immunoglobulins in gut-immune function, examining their involvement in mucosal defense, microbial regulation, and immune homeostasis within the intestines. We discuss the mechanisms of antibody production, highlighting how secretory IgA (sIgA) contributes to intestinal barrier integrity and pathogen neutralization. We also detail low secretory immunoglobulin A levels and Candida overgrowth. Lastly, we go through tools to support the gut-immune axis including oral immunoglobulin supplementation.1. Introduction   - Overview of immunoglobulins, roles in gut-immune health     - The gut as a constant interface with antigens, microbes, and potential pathogens     - Adequate but balanced immunoglobulin levels; preventing opportunistic pathogen overgrowth   2. Immunoglobulins     - Immunoglobulins (Ig) as glycoproteins, fundamental role in immune defense     - Five major immunoglobulin isotypes and their distinct roles     - How immunoglobulins recognize and neutralize pathogens / toxins / foreign antigens   3. Antibody Production in the Intestines    - Naïve B cells originate in the bone marrow, migrate to secondary lymphoid tissues     - Antigen-presenting cells (APCs) facilitate antigen processing and B cell activation     - Plasma cells and mucosal immunity   4. The Intestinal Barrier and Immune Components   - Layers of the gut barrier and their functions     - The role of gut-associated lymphoid tissue (GALT) in immune surveillance     - Immune cells within the lamina propria and their contributions to gut homeostasis   5. Secretory IgA (sIgA) and Its Role in Gut Immunity    - sIgA production and transport across the intestinal epithelium    - Role of sIgA in immune exclusion and pathogen neutralization  6. Factors That Can Influence sIgA Levels    - Chronic stress, infections, and gut inflammation as contributors to low sIgA     - Consequences of low sIgA, including increased susceptibility to pathogens     - Nutrients essential for supporting optimal sIgA levels   7. Other Key Immunoglobulins in Gut Immunity   - Immunoglobulin G's role in immune responses / pathogen neutralization    - Immunoglobulin M's location and function as an early immune responder in mucosal defense   8. Supplemental Immunoglobulins   - Oral immunoglobulin supplementation and its benefits    - Bovine colostrum as a source of immunoglobulins for intestinal and immune support   9. Conclusion     - Recap of immunoglobulins' role in gut-immune function    - The importance of balanced IgA, IgG, and IgM levels     - Strategies to support gut immunityThank you to our episode sponsor:1. Shop ⁠⁠CYLN's⁠⁠ full skincare line ⁠⁠here⁠⁠.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

ORELLA: "Putin quiere eliminar a Zelensky". Así juega Rusia sus cartas con EEUU para negociar la pazPutin está mostrando un cariz agradable hacia Trump, lógico, al recibir un reconocimiento internacional, tras su aislamiento en Occidente por la guerra de Ucrania, explica José Luis Orella, profesor de historia contemporánea de la Universidad CEU San Pablo. Y Trump ha dejado que no tiene ninguna química con Zelensky. "Una de las pretensiones de Putin es eliminar a  Zelensky", cada uno pone sus cartas encima de la meas en este inicio de negociaciones no solo por Ucrania sino por el orden mundial. "Trump tendría teclas para ser desagradable para presionar", pero Rusia es una potencia mundial. Hay un pasado y un presente: EEUU se quedó con las Islas Vírgenes en la IGM, y en la IIGM favoreció la secesión de la isla de Islandia. putin #zelensky #guerra #ucrania #paz #eeuu #trump #ukrainewar #tregua #invasionrusa #military #geopolitica #negociostvSi quieres entrar en la Academia de Negocios TV, este es el enlace:   https://www.youtube.com/channel/UCwd8Byi93KbnsYmCcKLExvQ/join Síguenos en directo ➡️ https://bit.ly/2Ts9V3pSuscríbete a nuestro canal: https://bit.ly/3jsMzp2Suscríbete a nuestro segundo canal, másnegocios: https://n9.cl/4dca4Visita Negocios TV https://bit.ly/2Ts9V3pMás vídeos de Negocios TV: https://youtube.com/@NegociosTVSíguenos en Telegram: https://t.me/negociostvSíguenos en Instagram: https://bit.ly/3oytWndTwitter: https://bit.ly/3jz6LptFacebook: https://bit.ly/3e3kIuy

【節目】這集來用portfoliovisualizer 來跑回測，看一下IGM跟QQQ的報酬、標準差等表現，再當面對到台股00770跟00662或009800時就可以用類似的表現來預期。 大綱 1.前言 2.回測期間 3.表現分析 4.風險與波動性 5.Sharpe Ratio、Sortino Ratio 6.市場的相關性 7.綜合比較 8.滾動報酬 9.結論 關鍵字 #IGM #QQQ #SPY #年化報酬率 #波動性 #最大回撤 #風險調整 #SharpeRatio #SortinoRatio #投資選擇 第510集，2025/02/27錄製 #AwesomeMoney #威利研究室 用研究改變你的財商視野 節目連結： YouTube 搜尋: 威利財經角 Podcast 搜尋: Awesome_Money 收看頻道會員節目: https://cutt.ly/HeRTJFB2 加入頻道會員: https://cutt.ly/zwTJf5e0 訂閱方格子 (文稿、程式範例): https://vocus.cc/willy03/home 威利投資生活事 Line 社群: https://forms.gle/CabjyDhux35utmyU9 免費電子報訂閱: https://cutt.ly/lwOV4s2Q 使用電子報原因: https://cutt.ly/kwOV4U8H 收聽|看文章|互動社群|目錄: https://cutt.ly/AwesomeMoney －－－－以下訊息由 SoundOn 動態廣告贊助商提供－－－－ NISSAN電驅學院活動開課中！ 試乘新能源車款ARIYA、X-TRAIL e-POWER、KICKS e-POWER，就有機會獲得「價值5萬元 Formula E電動方程式賽事日本東京站雙人之旅」，入主再享4萬配件金及低頭款低月付方案。 和郭泓志一同探索你的電動車適配度：https://sofm.pse.is/78v78s -- 臺南市安平「考古埕－尋找熱蘭遮市鎮」特展，首度公開熱蘭遮市鎮現地考古成果。更多資訊請上「臺南文資處」官網查詢。

【節目】009800 最近很熱門，基金規模來到23億，可以觀察得出有陸續增加，雖然對比00662 512億還是有很大的差距，但對比00770 60億，距離慢慢拉近中。009800跟00770都有配息，對於不賣股現金流有需求者，可能都是不錯的選擇。但因為009800上市時間短，如果要跟00770來比較，乾脆直接用對應美股的QQQ與IGM來比較，應該有參考價值。 大綱 1.前言 2.009800與00770的配息比較 3.009800當作配息版00662的可行性 4.報酬率比較 5.00770股息紀錄 6.00770股息成長性分析 7.配息與跌幅觀察-00770 8.跌幅觀察-00662 9.00770與00662跌幅對比 10.結論 關鍵字 #009800 #00770 #00662 #配息 #現金流 #報酬率 #跌幅 #科技股 #市場波動 #投資選擇 第509集，2025/02/27錄製 #AwesomeMoney #威利研究室 用研究改變你的財商視野 節目連結： YouTube 搜尋: 威利財經角 Podcast 搜尋: Awesome_Money 收看頻道會員節目: https://cutt.ly/HeRTJFB2 加入頻道會員: https://cutt.ly/zwTJf5e0 訂閱方格子 (文稿、程式範例): https://vocus.cc/willy03/home 威利投資生活事 Line 社群: https://forms.gle/CabjyDhux35utmyU9 免費電子報訂閱: https://cutt.ly/lwOV4s2Q 使用電子報原因: https://cutt.ly/kwOV4U8H 收聽|看文章|互動社群|目錄: https://cutt.ly/AwesomeMoney －－－－以下訊息由 SoundOn 動態廣告贊助商提供－－－－ 臺南市安平「考古埕－尋找熱蘭遮市鎮」特展，首度公開熱蘭遮市鎮現地考古成果。更多資訊請上「臺南文資處」官網查詢。 https://sofm.pse.is/78e2bu ▌展期｜2024/9/22~2025/3/23 ▌時間｜週三至週日及國定假日，09:00~17:00 ▌地點｜安平劍獅埕（臺南市安平區延平街35號） -- NISSAN電驅學院活動開課中！ 試乘新能源車款ARIYA、X-TRAIL e-POWER、KICKS e-POWER，就有機會獲得「價值5萬元 Formula E電動方程式賽事日本東京站雙人之旅」，入主再享4萬配件金及低頭款低月付方案。 和郭泓志一同探索你的電動車適配度：https://sofm.pse.is/78e2au -- Hosting provided by SoundOn

Episode 184: Multiple Myeloma BasicsSub-Interns and future Drs. Di Tran and Jessica Avila explain the symptoms, work up and treatment of multiple myeloma. Written by Di Tran, MSIV, Ross University School of Medicine; Xiyuan Yang, MSIV, American University of the Caribbean. Comments by Jessica Avila, MSIV, American University of the Caribbean. Edits by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Di: Hi everyone, this is Di Tran, 4th year medical student from Ross university.  It's a pleasure to be back.  To be honest, this project is a part of teamwork of two medical students, myself and another 4th year, her name is XiYuan.  She came from the AUC. Unfortunately, due to personal matters she was unable to make it to the recording today which makes me feel really sad. Jessica: My name is Jessica Avila, MSIV, American University of the Caribbean.Di: The topic we will present today is Multiple Myeloma. Multiple myeloma is typically a rare disease and it's actually a type of blood cancer that affects plasma cells in the bone marrow.Jessica: Let's start with a case: A 66-year-old male comes to his family doctor for an annual health checkup. He is not in any acute distress but he reports that he has been feeling tired and weaker than usual for the last 3 months. He also noticed that he tends to bruise easily. He has a history of arthritis and chronic joint pain, but he thinks his back pain has gotten worse in the last couple of months. Upon checking his lab values, his family doctor found that he has a calcium level of 10.8 and a creatinine level of 1.2, which has increased from his baseline. Given all that information, what do you think his family doctor is suspecting? And what kind of tests she can order for further evaluation?Di: Those symptoms sound awfully familiar – are we talking about the CRAB? You know, the diagnostic criteria for Multiple Myeloma.Jessica: Exactly! Those are called “myeloma-defining events.” Do you remember what those are?Di: CRAB criteria comes in 4 flavors.  It's HYPERCALCEMIA with >1mg/dL, RENAL INSUFFICIENCY with serum creatinine >2mg/dL, ANEMIA with hemoglobin value 10% plasma cells, PLUS any one or more of the CRAB features, we can make the official diagnosis of multiple myeloma. Di:  Before we go deeper, let's back up a little bit and do a little background.  So, what do we know about the immunoglobulins, also known as antibodies? Back from years of studying from medical school, we know that the plasma cells are the ones that producing the antibodies that help fight infections.  There  are various kinds that come with various functions.  Each antibody is made up of 2 heavy chains and 2 light chains.  For heavy chains, we have A, D, E, G, M and for light chains we have Kappa and Lambda.Jessica: Usually, the 5 possible types of immunoglobulins for heavy chains would be written as IgG, IgA, IgD, IgE, and IgM.  And the most common type in the bloodstream is nonetheless the IgG. Di: What is multiple myeloma? In myeloma, all the abnormal plasma cells make the same type of antibody, the monoclonal antibody.  The cause of myeloma is unknown, but there are lots of studies and evidence that show a number of potential etiologies, including viral, genetic, and exposure to toxic chemicals, especially the Agent Orange, which is a chemical used as herbicide and defoliant. It was used as a chemical warfare by the U.S. military during the Vietnam War from 1961 to 1971.Jessica: We need to order some specific blood tests to see if there is elevated monoclonal proteins in the blood or urine. So, to begin with we'll need to take a very thorough history and physical exam. Next, we'll do labs, such as CBC, basic metabolic panel, calcium, serum beta-2 microglobulin, LDH, total protein, and some not so common tests: serum protein electrophoresis (SPEP), immunofixation of blood or urine (IFE), quantitative immunoglobulins (QIg), serum free light chain assay, and serum heavy/light chain ratio assay.If any of the results is abnormal, we should consider referring our patient to an oncologist.Di: Interesting! I read that Multiple Myeloma symptoms vary in different patients.  In fact, about 10-20% of patients with newly diagnosed myeloma do not have any symptoms at all.   Otherwise, classic symptomatic presentations are weakness, fatigue, increased bruising under the skin, reduced urine output, weakened bones that is likely prone to fractures, etc. And if multiple myeloma is highly suspected, a Bone Marrow biopsy should be done with testing for flow cytometry and fluorescent in situ hybridization (FISH). Actually, if any of the “Biomarkers of malignancy (SLIM)” is met we can also diagnose multiple myeloma even without the CRAB criteria. Jessica: The diagnosis is made if one or more of the following is found: >= 60% of clonal plasma cells on bone marrow biopsy, > 1 lytic bone lesion on MRI that is at least 5mm in size, or a biopsy confirmed plasmacytoma. Di: Imaging comes in at the final step especially if we able to find one or more sites of osteolytic bone destruction > 5mm on an MRI scan.Jessica: What if the bone marrow biopsy returns > 10% of monoclonal plasma cells, but our patient doesn't have either the CRAB or the Biomarker criteria? Di: That's actually a very good question, since Multiple Myeloma is part of a spectrum of plasma cell disorders. That's when smoldering myeloma comes into play. It is a precursor of active multiple myeloma. Smoldering myeloma is further categorized as high-risk or low-risk based on specific criteria.A less severe form is called Monoclonal Gammopathy of Undetermined Significance, or simply MGUS, with < 10% bone marrow involvement. Those are diagnoses we give once we rule out actual multiple myeloma, which are defined by the amount of M-protein in the serum.Jessica:  When to get started on treatment? Multiple Myeloma is on a spectrum of plasma cells proliferative disorders, starting from MGUS to Smoldering Myeloma, to Multiple Myeloma and to  Plasma Cell Leukemia.  Close supervision/active watching is enough for MGUS and low risk Smoldering Myeloma. But once it has progressed to high-risk smoldering myeloma or to active Multiple Myeloma, chemotherapy is usually required. Some situations may require emergent treatment to improve renal function, reduce hypercalcemia, and to prevent potential infections.Di: As of 2024, treatment of Multiple Myeloma comprises the Standard-of-Care approved by the FDA. In fact, the quadruple therapy is a combination of 4 different class of drugs that include a monoclonal antibody, a proteasome inhibitor, an immunomodulatory drug, and a steroid. Jessica: They are Darzalex (daratumumab), Velcade (bortezomib), Revlimid (lenalidomide) and dexamethasone.  Other treatment plans for Multiple Myeloma include chemotherapy, immunotherapy, radiation therapy (for plasmacytomas) and stem cell transplants. The patient will also be on prophylaxis acyclovir and Bactrim while on chemotherapy. Sometimes anticoagulants are also considered because the chemo increases the risk of venous thromboembolic events.Di: Although the disease is incurable, but with the advancing of novel therapies and clinical trials patients with multiple myeloma are able to live longer.  Problem is the majority of patients diagnosed with Multiple Myeloma are older adults (>65), the risk of falling is adding to multiple complications of the disease itself, such as bone density loss, pain, neurological compromises, distress and weakness.  Palliative care may come in help at any point in time throughout the course of treatment but is most often needed at the very end of the course. Jessica, can you give us a conclusion for this episode?Jessica: Multiple Myeloma may not be the most common cancer, but we have to be aware of the symptoms and keep it in our differential diagnosis for patients with bone pain, easy bruising, persistent severe headaches, unexplained renal dysfunction, and remember the CRAB: HyperCalcemia, Renal impairment, Anemia and Bone lesions.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:International Myeloma Foundation. (n.d.). International Myeloma Working Group (IMWG) criteria for the diagnosis of multiple myeloma. https://www.myeloma.org/international-myeloma-working-group-imwg-criteria-diagnosis-multiple-myeloma Laubach, J. P. (2024, August 28). Patient education: Multiple myeloma symptoms, diagnosis, and staging (Beyond the Basics). UpToDate. https://www.uptodate.com/contents/multiple-myeloma-symptoms-diagnosis-and-staging-beyond-the-basics.University of California San Francisco. (n.d.). About multiple myeloma. UCSF Helen Diller Family Comprehensive Cancer Center. https://cancer.ucsf.edu/research/multiple-myeloma/about Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

International Guest Mix (IGM 008) Gowzer. Glasgow, SCODelighted to have the International Guest Mix Series back up and running with Gowzer. With Releases on The Soundgarden | Droid9 |AH Digital | SLC-6 | LUps Records | Tradeston Records | Transensation Records | Spiritual Enhancement, he's no stranger to creating big impact tracks on amazing international labels.A driving force in the Glasgow electronic music scene, Gowzer has over 25 years of experience behind the decks. Inspired by progressive house legends like Sasha and John Digweed, Hernan Cattaneo and Nick Warren. Gowzer has crafted a unique sound characterized by deep hypnotic grooves and atmospheric textures.A mainstay in Glasgow's club scene, Gowzer has played at various venues and has shared the stage with some of the industry's most respected DJs. His international presence has also grown and has seen his productions now played worldwide.His work has garnered strong support from influential figures like Hernan Cattaneo (with 5 tracks featured on his Resident podcast), Nick Warren, and other leading names in progressive house.With 3 Promo releases of his own on this mix, whatever your're doing whilst listening - Enjoy and leave some love if you like what you hear!IGM 008 - TracklistNicholas Rada/ Elenora - Higher SpaceLexicon Avenue and Matt Black - The Farthest (HAFT Remix)Daniel Arguedas - GravityMichael Bennett - Capertree (Alex Orion Remix)Nick Warren - Cobblepot - (Zankee Gulati)Gowzer - IDLuis Damora, Nila - Lose KontrolThomas Ferrell - Around ConstellationMatter, Alex Orion - MokshaGowzer - This is SkylineGowzer - IDJamies Stevens, Zankee Gulati - Low Tide (Ezequiel Arias Remix)Gowzer - IDFollow Gowzer On Social Media: Facebook- www.facebook.com/unique.mcgowan Instagram- www.instagram.com/gowzerdj/ Soundcloud- @gowzerglasgow Beatport- www.beatport.com/artist/gowzer/923047 Spotify- open.spotify.com/artist/2ke98avmWic1zSYheNlWj8 Tradeston Records- www.beatport.com/label/tradeston-records/90377 Bookings/ Guest Mixes/ Remixes- s.mcgowan32@gmail.com

Dr. Stacey Clardy discusses the fundamentals of the immune response to infection and explains how to accurately distinguish between past and current or recent infections.

Jesús Blanco nos trae una colección de bandas sonoras navideñas, algunas bastantes peculiares como la película sobre el parón por Navidad en la IGM.

TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member's ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Why RFK Jr is not suitable for HHS (YouTube) Write your Senators to oppose RFK Jr Support MicrobeTV ASV 2025 Susceptibility to infections in asylum seekers (NEJM) RSV hospitalization in adults (JAMA Net Open) Ethics failings at French university (Science) RSV transmission in New Zealand (Nat Commun) Glycan reactive IgM binds multiple viruses (SciImmunol) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game, and an article about its origin Vincent – In the Quantum World, Even Points of View Are Uncertain Listener Pick Ryan – A Dangerous Moment Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Welcome to the Indie Game Movement masterclass series! In this episode, we explore game-changing monetization strategies that balance revenue generation with player satisfaction. Our guest shares insights on innovative approaches, avoiding pitfalls, tracking trends, and refining models with player feedback.  If you're looking for sustainable revenue strategies that keep players happy, this episode is a must-listen. Want to get more from this episode and take further action? Learn more about the course Use code IGM for an exclusive discount!  Please note: The podcast will receive compensation if you purchase the course using the link above. This means the podcast will earn a commission if you purchase the course through the link, at no additional cost to you.   Episode Shownotes Link:

Esto es HistoCast. No es Esparta pero casi. Terminamos nuestro periplo los distintos frentes de batalla occidentales de la Gran Guerra con @ismael_historia, @tamtamveramendi y @goyix_salduero.Este episodio cuenta con la colaboración de AXA.Línea temporal y frentesSecciones Historia: - Oriente Medio - 5:17 - 1917 - 12:30 - 1918 - 2:58:00 - Fin de la guerra - 3:54:07 - Bibliografía - 4:18:20

  Welcome to the Indie Game Movement masterclass series! Today, we're diving into the importance of player engagement and how it's crucial for the success of indie games. Our guest shares their approach to creating games that captivate players, exploring key engagement elements, player motivations, and strategies to measure and adapt. If you want to learn how to foster meaningful connections with your players, this episode is for you. Want to get more from this episode and take further action? Learn more about the course Use code IGM for an exclusive discount!  Please note: The podcast will receive compensation if you purchase the course using the link above. This means the podcast will earn a commission if you purchase the course through the link, at no additional cost to you.   Episode Shownotes Link:

Welcome to the Indie Game Movement masterclass series! In this episode, we tackle the challenges of hooking and engaging players. Our guest shares insights, lessons learned, and strategies to captivate players, avoid common pitfalls, and build games that truly resonate. Whether you're looking to improve engagement or refine your approach, this episode is packed with actionable advice to help you take your game to the next level!  Want to get more from this episode and take further action? Learn more about the course Use code IGM for an exclusive discount!  Please note: The podcast will receive compensation if you purchase the course using the link above. This means the podcast will earn a commission if you purchase the course through the link, at no additional cost to you. Episode Shownotes Link:

In today's episode, we dive into the interplay between the gut and immune system, focusing specifically on the critical role of immunoglobulins in mucosal immunity. Immunoglobulins, specialized glycoproteins synthesized by B cells, serve as the frontline defenders within the gastrointestinal tract, where they neutralize pathogens and maintain immune homeostasis. We also explore the mechanisms by which these antibodies fortify the intestinal barrier and aid in preventing dysbiosis. We finish by going through tools for supporting immunoglobulins. Topics: 1. Introduction - Overview of the gut-immune axis and focus on immunoglobulins. - How low levels of immunoglobulins can contribute to dysbiosis. 2. What Are Immunoglobulins? - Immunoglobulins (Igs) are glycoproteins produced by B cells. - They play a critical role in recognizing and neutralizing pathogens. - Antigen-binding sites for specific targeting. - Essential for immune homeostasis and pathogen elimination. 3. Immunoglobulins' Role in the Gut - Protect mucosal surfaces exposed to antigens. - B cells differentiate into plasma cells, and secrete immunoglobulins into the gut lumen. 4. Layers of the Intestinal Lining - Intestinal lumen is covered by a protective mucus layer. - Mucosa consists of epithelial cells, including mucus-secreting goblet cells. - Lamina propria beneath the epithelium is rich in immune cells. - Submucosa beneath mucosa. 5. The Function of the Mucus Layer - Acts as a physical barrier against pathogens. - Functions as a biochemical barrier by housing antimicrobial peptides and immunoglobulins. - Primarily composed of mucins secreted by goblet cells. - Goblet cells release mucins in response to stimuli, forming gel-like mucus. 6. Introduction to Secretory Immunoglobulin A (sIgA) - sIgA is the most abundant immunoglobulin in mucosal secretions. - Forms a protective barrier in the mucus layer. - Plays a critical role in immune exclusion by trapping and neutralizing pathogens. - Helps maintain non-inflammatory defense at mucosal surfaces. 7. Production of Secretory IgA - Plasma cells in the lamina propria secrete IgA. - IgA binds to receptors on epithelial cells and is transported across to the gut lumen. - sIgA to neutralize pathogens effectively within the mucus layer. 8. Functions of Secretory IgA in the Gut - Binds to antigens like bacterial walls, viruses, and toxins. - Traps antigens in the mucus to prevent adherence to epithelial cells. - Provides immune exclusion, reducing pathogen access to the gut lining. - Maintains mucosal barrier integrity to prevent inflammation. 9. Impact of Low sIgA Levels - Contributes to dysbiosis by allowing pathogenic bacteria to proliferate. - Intestinal hyperpermeability. - Increased risk of intestinal inflammation and infections. 10. Comparison with Other Immunoglobulins: IgG and IgM - IgG is most abundant in blood. - IgM is produced early in immune responses. - IgM can also be secreted into the gut lumen in IgA deficiency. 11. Immunoglobulin Supplements - IgG supplements. - Colostrum: IgG to help neutralize pathogens. - Supports gut barrier integrity. 12. Supporting Immunoglobulin Levels - Colostrum - Probiotics, prebiotics - Vitamin A - Zinc 13. Conclusion - Immunoglobulins, intestinal health, and immune balance. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Send us a textJon Hersel Coach Hersel is the Head Strength and Conditioning Coach at Saraland High School in Saraland Alabama.Prior to taking the job at Saraland, Coach Hersel was at York High School in York S.C. He was the Associate Strength Coach at the University of South Alabama and worked with Baldwin County H.S., McGill Tooling and Spanish Fort High Schools. Hersel had multiple internships with stops at IGM, Ole Miss, Miami, and LSU. Coach Hersel currently holds a CSCS, USAW and, USATF. He has a Bachelor of Science Park and from Jamestown College in Physical education and, a Master's Degree in Parkand Recreation Management from Ole Miss.https://www.instagram.com/saraland_strength?igsh=MTd1dzZ2bmg1bmUwNg==https://x.com/jonhersel?s=21https://youtube.com/@platesandpancakes4593https://instagram.com/voodoo4power?igshid=YmMyMTA2M2Y=https://voodoo4ranch.com/To possibly be a guest or support the show email Voodoo4ranch@gmail.comhttps://www.paypal.com/paypalme/voodoo4ranch

Hann. Münden berät zurzeit darüber, welche Schulformen künftig in der Stadt angeboten werden sollen. Dazu befragt der Landkreis Göttingen die Eltern. Zur Diskussion steht unter anderem, ob es in Hann. Münden eine Gesamtschule geben soll. Nico Mader war daher bei einer Info-Veranstaltung der Initiative für eine Gesamtschule in Münden (IGM) vor Ort. Im Gespräch mit Benita Heukamp stellt er dar, wie die Schulsituation in Hann. Münden ist.

Esto es HistoCast. No es Esparta pero casi. Comenzamos un recorrido general por los campos de batalla occidentales de la Gran Guerra con @ismael_historia, @tamtamveramendi y @goyix_salduero.Línea temporal y frentesSecciones Historia: - Camino a la guerra - 15:54 - 1914 - 29:00 - 1915 - 2:11:05 - 1916 - 3:13:32 - Bibliografía - 4:55:01

Esto es BlitzoCast. No es HistoCast pero casi. En el directo, que celebramos en Cañas y Podcast 2024 el pasado 28 de Septiembre, hablamos de tanques rarunos y la introducción de dicha arma en los ejércitos. Por HistoCast acudieron @tamtamveramendi y goyix_salduero.Presentación del directo

This podcast discusses paraproteinemic neuropathies, featuring experts Dr. Michelle Maruman and Dr. Eli Naddaf. They explore the definition and clinical significance of monoclonal proteins, the necessary tests for diagnosing these conditions, and the various types of paraproteinemic neuropathies. The discussion covers IgM-associated neuropathies, including DADS, CANOMAD, and Waldenstrom's acroglobulinemia-associated neuropathies, as well as non-IgM neuropathies such as POEMS syndrome and light chain amyloidosis. The experts detail the clinical features, diagnostic criteria, and management approaches for these conditions, emphasizing the importance of accurate diagnosis and appropriate treatment. They conclude by reminding clinicians that the co-occurrence of peripheral neuropathy and monoclonal gammopathy in aging populations is often coincidental, and a careful evaluation is necessary to establish a causal relationship.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. The FDA decisions to watch from October 3-5 include the approval of a rival to a fast-selling Pfizer heart drug, a lung cancer medicine, and an addition to Vertex's cystic fibrosis business. Prime is narrowing its gene editing research and partnering with Bristol Myers, while Lilly plans to invest $4.5 billion in advanced drug manufacturing. IGM has laid off staff in an autoimmune pivot, Metsera is ramping up obesity drug supply, and other biotechs are focusing on T cell engagers for treating inflammatory conditions. The newsletter also covers recent developments in gene therapy, including stem cells reversing diabetes in a world-first case and the slow adoption of gene therapy for sickle cell disease. Biopharma Dive provides insights into the latest news and trends in biotech and pharma, from clinical trials to drug pricing and research partnerships.

Gábor és Zoli ezúttal két olyan csapatot vett elő, ahol kapcsoltak, hogy ez így nem mehet tovább. A tankverseny egyik fő esélyese a Nets, ahol Igmándy Áron segítségével megy a diskurzus, a keretben erősebb, de szintén újjáépülni vágyó Bullsnál pedig Tóth Attila a vendég! Learn more about your ad choices. Visit megaphone.fm/adchoices

What is a common-sense approach to testing for Tick-borne infection. I focus on the most common infections that I see a Lyme disease infection. I order a Lyme disease test as well as test for infections like Ehrlichia, Anaplasmosis, and Babesia. I don't typically order Mycoplasma or Chlamydia unless there is evidence that there's active infection.  I order an ELISA test, which is also called Lyme titer.  I also order a western blot and IgG and IgM test. These are test where you need two out of three bands IgM bands. You need five out of 10 IgG bands to be called positive by the CDC criteria. These are bands that were identified and in 1994 at a consensus meeting in Dearborn Michigan.  These markers are protein that have been identified in Lyme disease infections.  For example, the 41 kDa band represents a protein contained in the tail of a spirochete. I have not been ordering a C6 peptide or VlsE protein tests for Lyme disease as they are not as reliable as I would like.  None of these tests for Lyme disease are all that sensitive in my experience.  I have often had to use clinical judgement to diagnose and treat Lyme disease. I also order IgG and IgM tests for co-infections with Babesia, Bartonella, Anaplasmosis, and Ehrlichia. I have not found PCR tests for these co-infections as helpful as I would like. I have found a blood smear for Babesia not helpful if a patient has been sick more than 2 weeks.   Some doctors have assumed Bartonella tests have been positive due to exposure to fecal matter from mites living on cats. I can't be sure the cause of positive tests for Bartonella in patients with Lyme disease.  I don't typically ordered labs for infections such as tularemia or Brucellosis despite concerns by some of my colleagues. I have found treatment for Lyme disease would take care of these infections if they were present. I typically do not sent bloods to a specialty lab if someone's on a budget. I also do not send bloods to these labs if I am going to treat clinically.   I also order extensive testing to rule other illnesses like a CBC, comprehensive metabolic profile, ANA, RA, thyroid, sed rate, vitamin B12 and D.    I may order a free T4 and free T3 if I am considering a thyroid condition.  I have found ANA frustrating as most of the ANA tests are false positive. A positive dsDNA supports the diagnosis of lupus. My patients don't typically have three other conditions that would support the diagnosis of Lupus. I refer my patients to see a rheumatologist if there is a need to rule out lupus. I typical order blood test for a tick-borne illness four weeks or 4 to 6 weeks after onset of their illness to increase the chances that I might get a positive test.  I have had to use clinical judgement to treat a tick-borne infection if my patient is sick for less than 4 weeks or if I suspect a false negative test,

Welcome! Today, we're discussing the treatment of Babesia and Lyme disease, focusing on real patient experiences and effective treatment strategies.I had a patient who remained chronically ill six months after treating for Lyme disease. Despite exhaustive evaluations, she was still symptomatic. Her antibody tests came back positive for Babesia, although her thick smear and PCR were negative. She believed Babesia was asymptomatic since it wasn't seen in her red blood cells, but she was very symptomatic. Babesia is a parasite transmitted by the same deer ticks that carry Lyme disease. Some patients have Babesia parasites visible in their red blood cells under a microscope, usually seen at the onset of the illness for one to two weeks. In some cases, especially in the elderly or immunocompromised, the parasite can persist longer, leading to severe illness requiring intensive care." Some Babesia patients don't experience acute, life-threatening illness and might not have visible parasites in blood smears. Instead, positive antibody tests for Babesia, such as IgM and IgG for Babesia microti or Babesia duncani, can indicate the presence of the infection. I've seen positive Babesia duncani tests even on the east coast, suggesting the need for further research. I've had patients who, despite negative tests, improved after Babesia treatment. These patients often failed treatments for Lyme disease, Anaplasmosis, Ehrlichia, and Bartonella for months or years, unaware that Babesia could be a co-infection. For Babesia treatment, I avoid quinine and clindamycin due to their higher rate of side effects. Instead, I recommend atovaquone combined with azithromycin, which is more tolerable. Atovaquone is marketed as Malarone and Mepron in the USA. Malarone is a pill, while Mepron is a thick yellow liquid. Malarone is generally less expensive and more convenient. Malarone also comes in a pediatric dose, making it easier to tolerate for patients with an upset stomach or those concerned about a Herxheimer reaction. I usually prescribe 30 days of atovaquone, longer than the 10 days suggested by some studies, as my patients often aren't treated at the onset of their Babesia infection." I combine atovaquone with azithromycin and discuss the risks of azithromycin versus untreated Babesia. If necessary, I consult a cardiologist to rule out prolonged QT interval and treat for the same duration as atovaquone." If a patient can't take azithromycin or if there's a possibility of co-infection with Anaplasmosis or Ehrlichia, I may substitute doxycycline. For patients failing atovaquone with azithromycin, tafenoquine (Arakoda) has been introduced as an alternative. Although it's currently difficult to obtain, it has shown some success in persistent Babesia cases." Atovaquone is often covered by prescription plans, and services like GoodRx can reduce the cost to less than $80 in some communities. This makes it a viable option for many patients. Conclusion Treating Babesia is often overlooked in patients with recurrent or prolonged illnesses. With ongoing research and new treatments, there's hope for better management and outcomes for patients with Babesia and Lyme disease. Thanks for watching, and stay tuned for more insights on managing tick-borne diseases."

Chiropractor Kim Bruno furthered her training with the Institute of Functional Medicine, ILADS, Horowitz Lyme Master Classes and holds a board-certification as a Certified Clinical Nutritionist. She owned a private practice for 17 years and was the functional medicine medical director for the largest immunology clinic in Colorado. She comes to us today as the Senior Medical Science liaison for Vibrant Wellness Labs. Today we discuss their panel of 48 neurologically-oriented antibodies: the Neural Zoomer Plus. We start by discussing the lab technology itself, which is somewhat unique in the testing world- it's an 'Immunochip', also called a protein-peptide microarray as viewed through chemiluminescence which can be more sensitive than historical Eliza testing. The sensitivity (the ability to find the needle in the haystack) ranges from 95-98% and the specificity (it's definitely a needle, and not a pin or nail or something similar that is not actually a needle) is 96-100%. The range is because each analyte has its own metrics. Here, we take a tangent into describing the limitations of Eliza & Western Blot testing, especially in light of tick-borne testing for Lyme disease & co-infections. Then we touch on PCR- polymerase chain reaction testing and the use of glass beads to break up biofilms in test samples for even more accurate results.   Our next chapter (around 14:30) focuses on the immune system itself. Listen in for some helpful analogies for the immunoglobulins-IgM for ‘marines vs IgG for ‘ground troops', IgA with affiliation with mucus membranes like the gut or respiratory linings, and IgE for anaphylactic allergic reaction. This gives the total pool from which the Neural Zoomer Plus antibodies are pulling from as a sort of clinical calibration to weigh the presence of the specific antibodies.   At 22:20, we dive into the Neural Zoomer Plus test itself. Dr Bruno shares her brilliant ‘hierarchy of consideration' for putting these antibodies into a context. While she states outright ‘this is not a diagnostic test', the larger truth is that this test cannot be used for diagnosis by clinicians who don't have the scope to make diagnostic conclusions, for example dieticians or health coaches. For our purposes at Neuroveda Health, we absolutely use this test for clinical decision making and diagnosis. Dr Bruno calls out molecular mimicry against pathogens or even foods or toxins that can confuse the immune system. We consider the Cunningham Panel (recently renamed the Autoimmune Brain Panel), which has been used longer for PANDAS evaluation. And we walk through each category of antibody included on this test.   We finish with a discussion about treatment approaches based on results from this test, including the Neuroveda Health approach to evaluating and addressing neuroimmune disease. FOR MORE INFORMATION: To look at a sample report of this test: https://hello.vibrant-wellness.com/hubfs/Sample%20Reports/MK-0072-01NeuralZoomerPlusSampleReport.pdf To find out more about the Neural Zoomer Plus test: https://www.vibrant-wellness.com/test/NeuralZoomerPlus To get testing, contact us to schedule an appointment with a clinician at Neuroveda Health: - Phone: 206-379-1213 - Email Reception@neurovedahealth.com To find out more about our clinic (and request a call back): https://www.neurovedahealth.com/

The importance of muscle mass; What is the meaning of IgG, IgA and IgM. I'm concerned about my immune system; How do you feel about Black Seed Oil for immune support?

Welcome to the Instant Trivia podcast episode 1217, where we ask the best trivia on the Internet. Round 1. Category: Getting Jazzed 1: Introduced in 1948, these items let jazz become more complex by allowing longer performances on a single side. LPs. 2: Look away, look away, look away, it's a revivalist style of New Orleans jazz. Dixieland. 3: Billy Strayhorn composed classics like "Take The 'A' Train" during his collaboration with this bandleader. Duke Ellington. 4: In 1998 Ellis, patriarch of this jazz family, released his own trio album, "Twelve's It". Marsalis. 5: In the '70s Weather Report had "nuclear" results with this style that combined jazz and rock. fusion. Round 2. Category: 1949 1: On August 23 a manslaughter charge was filed against the cabbie who killed this "Gone with the Wind" author. (Margaret) Mitchell. 2: On January 31 the U.S. formally recognized Transjordan and this country. Israel. 3: This camera which produced a print in 60 seconds went on sale May 11. a Polaroid. 4: There were about 40,000 horologists making these in the U.S.. clocks (watches). 5: Mohammed Reza Pahlavi, shah of this country, was wounded when a reporter fired 5 shots at him. Iran. Round 3. Category: Waist Up, Neck Down 1: "Breadbasket" is slang for the midsection or specifically this digestive organ. the stomach. 2: The cecum is part of the large intestine; animals use it to digest this kind of food, so in koalas, it's 3 times body length. plants (vegetation). 3: Filtering the entire contents of your blood as many as 40 times a day is the job of this pair of organs. the kidneys. 4: As part of the body's immune response, the spleen releases these proteins such as IgM that counteract pathogens. antibodies. 5: The formation of solid deposits also called choleliths is a common occurrence in this organ. the gallbladder. Round 4. Category: Show Biz Shelleys 1: 3 "cheers" for this actress who played waitress Diane Chambers. Shelley Long. 2: While playing Mary Stone on The Donna Reed Show, she had a #1 hit with "Johnny Angel". Shelley Fabares. 3: The TV boss she worked for and perfume she represented were both named Charlie. Shelley Hack. 4: He said, "I'm not a sick comedian; I'm a healthy actor". Shelley Berman. 5: When Clark Gable came to pick her up, she thinks her mother may have said, "Don't be careful". Shelley Winters. Round 5. Category: America Literature 1: While walking, this Washington Irving character comes upon a party of odd-looking men playing ninepins. Rip Van Winkle. 2: In "Moby Dick" this captain dies when a harpoon line loops around his neck and pulls him overboard. Ahab. 3: In this Steinbeck work, dimwitted Lennie Small has a vision of his Aunt Clara. Of Mice and Men. 4: After Judge Pyncheon's death, this Hawthorne title home is left to Hepzibah and her brother Clifford. the House of Seven Gables. 5: Tom Sawyer is ordered to whitewash a fence because this brother tells Aunt Polly Tom played hooky. Sid. Thanks for listening! Come back tomorrow for more exciting trivia!Special thanks to https://blog.feedspot.com/trivia_podcasts/ AI Voices used

Ellen Vaughn is a New York Times bestselling author and speaker who has written or co-written twenty-four books. In this episode, she shares of her life-long passion for writing and storytelling and how her faith continues to inform her work. Former vice president of executive communications at Prison Fellowship, she collaborated with the late Chuck Colson on a number of his seminal works. She speaks at conferences, often travels to interview Christ-followers in hostile parts of the world, and serves on the board of directors for IGM, the global church developer.

BUFFALO, NY- April 16, 2024 – A new #researchpaper was #published in Oncotarget's Volume 15 on April 12, 2024, entitled, “Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface.” The B-cell receptor regulates B-cell proliferation and apoptosis. Aberrations in BCR signaling are associated with the development and progression of B-cell malignancies, such as mantle cell lymphoma, diffuse large B-cell lymphoma, and chronic lymphocytic leukemia, many of which express the IgM type of BCR on their cellular surface. Therefore, IgM is an attractive target for therapeutic antibodies against B-cell malignancies. However, soluble IgM competitively binds to anti-IgM antibodies in the serum, and these antibodies show insufficient cytotoxic activity. Thus, antibody therapy targeting IgM is hindered by the presence of soluble IgM in the blood. In this new study, researchers Takahiro Ohashi, Sayuri Terada, Shinsuke Hiramoto, Yuko Nagata, Hirokazu Suzuki, Hitoshi Miyashita, Tetsuo Sasaki, Yasukatsu Tsukada, and Keiko Fukushima from ZENOAQ (Zenyaku Kogyo Co., Ltd.) used a bispecific antibody to address this problem. “In this study, we aimed to produce IgM-dependent bispecific antibodies targeting IgM and the other B-cell antigens such as CD20, CD32b (FcγRIIB), CD79b, and human leukocyte antigen (HLA)-DR using the Cys1m technology [10, 43–45]. Additionally, the correct IgG-like bispecific antibody structures were confirmed and their efficacies in the presence of soluble IgM were analyzed.” The researchers generated bispecific antibodies bound to IgM and other B-cell antigens such as CD20 and HLA-DR using their own bispecific antibody-producing technology, Cys1m. These bispecific antibodies directly inhibited cell proliferation via cell-cycle arrest and apoptosis in vitro, although large amounts of soluble IgM were present. Additionally, a bispecific antibody bound to IgM and HLA-DR (BTA106) depleted B-cells in cynomolgus monkeys. “These data suggest that anti-IgM/B-cell surface antigen-binding specific antibodies are promising therapeutic agents for B-cell malignancies. Moreover, the bispecific antibody modality can potentially overcome problems caused by soluble antigens.” DOI - https://doi.org/10.18632/oncotarget.28578 Correspondence to - Keiko Fukushima - keiko_fukushima@mail.zenyaku.co.jp Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28578 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, bispecific antibody, Cys1m, IgM, lymphoma, cynomolgus monkey About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Esto es BlitzoCast. No es HistoCast pero casi. No es HistoCast pero casi. Ya estamos muy cerca de cerrar las inscripciones para viajar al Mosa con @tamtamveramendi y @HugoACanete. Informamos de ello junto a goyix_salduero.

Episode 164: More Than Just A HeadacheDr. Song presents a case of a subacute headache that required an extensive workup and multiple visits to the hospital and clinic to get a diagnosis. Dr. Arreaza added comments about common causes of subacute headaches.    Written by Zheng (David) Song, MD. Editing and comments by Hector Arreaza, MD.  You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction to the episode: We are happy to announce the class of 2027 of the Rio Bravo / Clinica Sierra Vista Family Medicine Residency Program. Our new group will be (in alphabetical order): Ahamed El Azzih Mohamad, Basiru Omisore, Kenechukwu Nweke, Mariano Rubio, Nariman Almnini, Patrick De Luna, Sheila Toro, and Syed Hasan. We welcome all of you. We hope you can enjoy 3 enriching and fulfilling years. During this episode, you will hear a conversation between Dr. Arreaza and Dr. Song. Some elements of the case have been modified or omitted to protect the patient's confidentiality. 1. Introduction to the case: Headache. A 40-year-old male with no significant PMH presents to the ED in a local hospital due to over a month history of headaches. Per the patient, headaches usually start from the bilateral temporal side as a tingling sensation, and it goes to the frontal part of the head and then moves up to the top of the head. 8 out of 10 severities were the worst. Pt reports sometimes hypersensitivity to outdoor sunlight but not indoor light. OTC ibuprofen was helpful for the headache, but the headache always came back after a few hours. The patient states that if he gets up too quickly, he feels slightly dizzy sometimes, but it is only for a short period of time. There was only one episode of double vision lasting a few seconds about 2 weeks ago but otherwise, the patient denies any other neurological symptom. He does not know the cause of the headache and denies any similar history of headaches in the past. The patient denies any vomiting, chest pain, shortness of breath, cough, abdominal pain, or joint pain. The patient further denies any recent traveling or sick contact. He does not take any chronic medication. The patient denies any previous surgical history. He does not smoke, drink, or use illicit drugs. What are your differential diagnoses at this moment? Primary care: Tension headache, migraines, chronic sinusitis, and more.2. Continuation of the case: Fever and immigrant.Upon further inquiries, the patient endorses frequent “low-grade fever” but he did not check his temperature. He denies any significant fatigue, night sweats, or weight loss. He migrated from Bolivia to the U.S. 12 years ago and has been working as a farm worker in California for the past 10 years. He is married. His wife and daughter are at home in Bolivia. He is currently living with friends. He is not sexually active at this moment and denies having any sexual partners. Differential diagnoses at this moment?  Tension headache, migraine, infections, autoimmune disease, neurocysticercosis. 3. Continuation of the case: Antibiotics and eosinophilia. As we kept asking for more information, the patient remembered he visited a clinic about four months ago for a dry cough and was told he had bronchitis and was given antibiotics and the cough got better after that. He went to another local hospital ED one month after that because the cough came back, now with occasional phlegm and at that time he also noticed two “bumps” on his face but nothing significant. After a CXR at the ED, the patient was diagnosed with community-acquired pneumonia and sent home with cough medication and another course of antibiotics. His cough improved after the second round of antibiotics. We later found on the medical record that the CXR showed “mild coarse perihilar interstitial infiltrates of unknown acuity”. His blood works at the ED showed WBC 15.2, with lymphocyte 21.2%, monocyte 10.1%, neutrophil 61.7%, eosinophil 5.9% (normally 1-4%), normal kidney, liver functions, and electrolytes, and prescribed with benzonatate 100mg TID and doxycycline 100mg bid for 10 days. He went to the same ED one month before he saw us for headache and fever (we reviewed his EMR, and temp was 99.8F at the ED). After normal CBC, CMP and chest x-ray. The patient was diagnosed with a viral illness and discharged home with ibuprofen 400mg q8h.Due to the ongoing symptoms of headache and fever, the patient went back to the same clinic he went to four months ago for a dry cough and requested a complete physical and blood work. The patient was told he had a viral condition and was sent home with oseltamivir (Tamiflu®) for five days. However, the provider did order some blood work for him. Differential diagnoses at this moment?  Patients with subacute meningitis typically have an unrelenting headache, stiff neck, low-grade fever, and lethargy for days to several weeks before they present for evaluation. Cranial nerve abnormalities and night sweats may be present. Common causative organisms include M. tuberculosis, C. neoformans, H. capsulatum, C. immitis, and T. pallidum. At his physical exam visit, the patient actually asked the provider specifically to check him for coccidiomycosis because of his job as a farm worker and he heard from his friends that the infection rate is pretty high in the Central Valley of California. His serum cocci serology panel showed positive IGG and IGM with CF titer of 1:128. His HIV, syphilis, HCV, HBV are all negative. The patient was told by that clinic to come to ED due to his history of headache, fever, and very high serum coccidiomycosis titer.  The senior and resident intern were on the night shift that night and we were contacted by the ED provider at around 9:30 pm for this patient. When reviewing his ED record, his vitals were totally normal at the ED, the preliminary ED non-contrast head CT showed no acute intracranial abnormality. A lumbar puncture was performed by the ED provider, which showed WBCs (505 - 71%N, 20%L, 7%M), RBC (1), glucose (19), and protein (200). CSF: High Leukocytes, low glucose, and high protein.On the physical exam, the patient was pleasant and cooperative, he was A&O x 4, he had a normal examination except for two brown healing small nodules on his forehead and left cheek and slight neck stiffness. At that point, we knew the patient most likely had fungal meningitis by cocci except for the predominant WBC in his CSF fluid was neutrophil not the more typical picture of lymphocyte dominant. And because of his very benign presentation and subacute history, we were not 100% sure if we had a strong reason to admit this patient. We thought this patient could be managed as an outpatient with oral fluconazole and referred to infectious disease and neurology. 4. Continuation of case: Admission to the hospital.Looking back, one thing that was overlooked while checking this patient in the ED was the LP opening pressure. Later, the open pressure was reported as 340mm H2O (very high). The good thing was, after speaking to the ED attending and our attending, the patient was admitted to the hospital and started on oral fluconazole.  Three hours after the admission, a rapid response was called on him. While the floor nurses were doing their check-in physical examination, the patient had a 5-minute episode of seizure-like activity which included bilateral tonic arm/hand movements, eye deviation to the left, LOC unresponsive to sternal rub, and the patient desaturated to 77%. He eventually regained consciousness after the seizure and pulse oximetry increased to 100% on room air. The patient was started on Keppra and seen by a neurologist the following day. His 12-hour EEG was normal, but his head MRI showed “diffuse thickening and nodularity of the basal meninges are seen demonstrating enhancement, suggesting chronic meningitis, possibly related to cocci. Other etiologies including sarcoidosis and TB meningitis and/or infiltration by metastatic process/lymphoma are not excluded. The ventricles are slightly prominent in size”. MRI of the cervical, thoracic, and lumbar spines also showed extensive diffuse leptomeningeal thickening, extensive meningitis, and nodular dural thickening. Also, his chest x-ray showed “some heterogeneity and remodeling of the distal half of the left clavicle. Metabolic bone disease, infectious etiology and/old trauma considered”. This could also be due to disseminated cocci infection. The infectious disease doctor saw this patient and recommended continuing with fluconazole, serial LPs until opening pressure is less than 250 mmH2O and neurosurgery consultation for possible VP shunt placement. The neurologist recommended the patient continue with Keppra indefinitely in the context of structural brain damage secondary to cocci meningitis.Take home points: Suspect cocci meningitis in patients with subacute headache associated with respiratory symptoms, new skin lesions, photophobia, neck stiffness, nausea, vomiting, eosinophilia, erythema nodosum (painful nodules on the anterior aspect of legs). Other symptoms to look for include arthralgias, particularly of the ankles, knees, and wrists.____________________Brief summary of coccidiomycosis. Etiology Coccidioidomycosis, commonly known as Valley fever, is caused by dimorphic soil-dwelling fungi of the genus Coccidioides (C. immitis and C. posadasii). They are indistinguishable in clinical presentation and routine laboratory test results.1, 2, 3, 5Epidemiology In the United States, endemic areas include the southern portion of the San Joaquin Valley of California and the south-central region of Arizona. However, infection may be acquired in other areas of the southwestern United States, including the southern coastal counties in California, southern Nevada, southwestern Utah, southern New Mexico, and western Texas (including the Rio Grande Valley). There are also cases in eastern Washington state and in northeastern Utah. Outside the United States, coccidioidomycosis is endemic to northern Mexico as well as to localized regions of Central and South America.1, 2Overall, the incidence within the United States increased substantially over the 1998-2019, most of that increase occurred in south-central Arizona and in the southern San Joaquin Valley of California. From 1998 to2019, reported cases in California increased from 719 to 9004.1, 6The risk of infection is increased by direct exposure to soil harboring Coccidioides. Past outbreaks have occurred in military trainees, archaeologists, construction or agricultural workers, people exposed to earthquakes or dust storms. However, in endemic areas, many cases of Coccidioides infection occur without obvious soil or dust exposure and are not associated with outbreaks. Change in population, climate change, urbanization and construction activities, and increased awareness and reporting, are possible contributing factors.1, 2, 5 Pathology In the soil, Coccidioides organisms exist as filamentous molds. Small structures called arthroconidia from the hyphae may become airborne for extended periods. Arthroconidia are usually 3-5 μm—small enough to evade bronchial tree mucosal mechanical defenses and reach deep into the lungs.1, 3Once inhaled by a susceptible host into the lung, the arthroconidia develop into spherules (theparasitic existence in a host), which are unique to Coccidioides. Endospores from ruptured spherules can themselves develop into spherules, thus propagating infection locally.1, 3, 5Although rare cases of solid organ donor-derived or fomite transmitted infections have been reported, coccidioidomycosis does not occur in person-to-person or zoonotic contagion, and transplacental infection in humans has never been documented.2, 5Cellular immunity plays a crucial role in the host's control of coccidioidomycosis. Among individuals with decreased cellular immunity, Coccidioides may spread locally or hematogenously after an initial symptomatic or asymptomatic pulmonary infection to extrathoracic organs.1, 3, 7Clinical manifestationThe majority of infected individuals (about 60%) are completely asymptomatic. Symptomatic persons (40% of cases) have symptoms that are related principally to pulmonary infection, including cough, dyspnea, and pleuritic chest pain. Some patients may also experience fever, headache (common finding in early-stage infection and does not represent meningitis), fatigue, night sweats, rash, myalgia.1, 2, 3, 5In most patients, primary pulmonary coccidioidomycosis usually resolves in weeks without sequelae and lifelong immunity to reinfection. However, some patients may develop chronic pulmonary complications, such as nodules or pulmonary cavities, or chronic fibrocavitary pneumonia. Some individuals with intense environmental exposure or profoundly suppressed cellular immunity (e.g., in patients with AIDS) may develop a primary pneumonia with diffuse reticulonodular pulmonary process in association with dyspnea and fever.1, 3, 5Fewer than 1% of infected individuals develop extrathoracic disseminated coccidioidal infection. Common sites for dissemination include joints and bones, skin and soft tissues, and meninges. One site or multiple anatomic foci may be affected. 1, 2, 3, 7It is estimated that coccidioidal meningitis, the most lethal complication of coccidioidomycosis, affects only 0.1% of all exposed individuals. Patients with coccidioidal meningitis usually present with a persistent headache (rather than a self-limited headache in some patients with primary pulmonary infection), with nausea and vomiting, and sometimes vision change. Some may also develop altered mental status and confusion. Meningismus such as nuchal rigidity, if present, is not severe.Hydrocephalus and cerebral infarction may develop in some cases. Papilledema is more commonly observed in pediatric patients.1, 3, 4, 5, 7When meningitis develops, most patients may not have any respiratory symptoms nor radiographic manifestation of pulmonary infection. However, a large number of these individuals also present with other extrathoracic lesions.7DiagnosisAlthough early diagnosis carries obvious benefits for patients and the health care systems as a whole (e.g., decreases patient anxiety, reduces the cost of expensive and invasive tests, removes the temptation for empirical antibacterial or antiviral treatments, and allows for early detection of complications), considerable diagnostic delays up to several weeks to months are common in both endemic areas and non-endemic areas.3, 7 Most symptomatic persons with coccidioidal infection present with primarily pulmonary symptoms and are often misdiagnosed as community-acquired bacterial pneumonia and treated with antibiotics. In endemic areas like south-central Arizona, previous studies found up to 29% of community-acquired pneumonia is caused by coccidioidomycosis. Healthcare providers thus should maintain a high clinical suspicion for coccidioidomycosis when evaluating persons with pneumonia who live in or have traveled to endemic areas recently. Elevated peripheral-blood eosinophilia of over 5%, hilar or mediastinal adenopathy on chest radiography, marked fatigue, and failure to improve with antibiotic therapy should prompt suspicion and testing for infection with coccidioidomycosis in endemic areas.1, 3, 5Serological testing plays an important role in establishing a diagnosis of coccidioidomycosis. Enzyme immunoassay (EIA) to detect IgM and IgG antibodies is highly sensitive and therefore commonly used as the screening tool. Immunodiffusion is more specific but less sensitive than enzyme immunoassay. It is used to confirm the diagnosis of positive EIA test results. Complement fixing (CF) test, which indirectly detects the presence of coccidioidal antibodies by testing the consumption of serum complement, are expressed as titers. Serial measurements of titers are of not only diagnostic but also prognostic value.1, 2, 3, 5Other methods, including culture, microscopic, or polymerase chain reaction (PCR) exam on tissue or respiratory specimens, are limited by their availability, sample obtaining and handling, or lack of sufficient evaluation.1, 2, 3, 5Cerebrospinal fluid (CSF) examination in coccidioidal meningitis usually demonstrates lymphocyte dominated elevation of leukocytes, although polymorphonuclear leukocyte dominance can also be seen in the early stage of the infection. Profound hypoglycorrhachia and elevated protein levels in CSF examination are also very common in coccidioidal meningitis.1, 7Although isolating Coccidioides from CSF or other CNS specimens are diagnostic for coccidioidal meningitis, in practice, diagnoses are often made based on the combination of clinical presentation, CSF examination that suggesting fungal infection, and positive Coccidioides antibodies found in CSF.7Imaging, especially enhanced magnetic resonance imaging (MRI), can help in diagnosing coccidioidal meningitis. Basilar leptomeningeal enhancement is a more common finding even though hydrocephalus, cerebral infarction, and vertebral artery aneurysm can also be seen.7TreatmentMost patients with focal primary pulmonary coccidioidomycosis do not require antifungal therapy. According to 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline, antifungal therapy should be considered in patients with concurrent immunosuppression that adversely affect cellular immunity (e.g., organ transplant patients, AIDS in HIV-infected patients, and patients receiving anti–tumor necrosis factor therapy) and those with significantly debilitating illness, extensive pulmonary involvement, with concurrent diabetes, pregnant women, or who are otherwise frail because of age or comorbidities. Some experts would also include African or Filipino ancestry as indications for treatment. Conversely, humoral immunity comprise splenectomy, hypocomplementemia, or neutrophil dysfunction syndromes are not major risk factors for this disease.1, 2, 3, 4, 5Triazole antifungals (fluconazole or itraconazole) are currently considered as the first-line medications used to treat most cases of coccidioidomycosis. Amphotericin B is reserved for only the most severe cases of dissemination and patients with coccidioidal meningitis in whom triazole antifungal therapy has failed. It is also the choice of therapy for coccidioidomycosis in pregnant women during the first trimester because of the possible teratogenic effect of high-dose triazole therapy during this period of time.1, 3, 4, 5Treating coccidioidal meningitis (CM) poses a special challenge because untreated meningitis is nearly always fatal. Lifelong therapy is recommended for CM because the majority 80% patients with CM experience relapse when therapy is stopped despite initial response to antifungal treatment. Shunting of CSF is required in cases of meningitis complicated by hydrocephalus.1, 3, 4, 5, 7Prevention Avoidance of direct contact with contaminated soil in endemic areas (e.g., respirator use by construction workers) may reduce disease risk, although clear evidence of its benefit is lacking.1, 5Some special population groups may benefit from prophylactic use of antifungals, such as those about to undergo allogeneic solid-organ transplantation or patients with a history of active coccidioidomycosis or a positive coccidioidal serology in whom therapy with tumor necrosis factor α antagonists is being initiated. The administration of prophylactic antifungals is not recommended for HIV-1-infected patients even if they live in an endemic region.1, 5Conclusion: Now we conclude episode number 164, “More than just a headache.” Dr. Song explained that a headache with an indolent course, accompanied by subacute respiratory symptoms, nausea, vomiting, photophobia, neck stiffness, and skin lesions can be secondary to Valley Fever. The Central Valley of California, as well as other areas with dry climate, are endemic and we need to keep this disease in our differential diagnosis.This week we thank Hector Arreaza and Zheng (David) Song. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Roos KL, Tyler KL. Acute Meningitis. McGraw Hill Medical. Published 2023. Accessed August 18, 2023. https://accessmedicine.mhmedical.com/content.aspx?bookid=2129§ionid=192020493Information for Healthcare Professionals. Published 2023. Accessed August 18, 2023. https://www.cdc.gov/fungal/diseases/coccidioidomycosis/health-professionals.html#printValley Fever (Coccidioidomycosis) a Training Manual for Primary Care Professionals. Accessed August 18, 2023. https://vfce.arizona.edu/sites/default/files/valleyfever_training_manual_2019_mar_final-references_different_colors.pdfAmpel NM. Coccidioidomycosis. Idsociety.org. Published July 27, 2016. Accessed August 18, 2023. https://www.idsociety.org/practice-guideline/coccidioidomycosis/Herrick KR, Trondle ME, Febles TT. Coccidioidomycosis (Valley Fever) in Primary Care. American Family Physician. 2020;101(4):221-228. Accessed August 18, 2023. https://www.aafp.org/pubs/afp/issues/2020/0215/p221.htmlValley Fever Statistics. Published 2023. Accessed August 18, 2023. https://www.cdc.gov/fungal/diseases/coccidioidomycosis/statistics.htmlUpToDate. Uptodate.com. Published 2023. Accessed August 18, 2023. https://www.uptodate.com/contents/coccidioidal-meningitis?search=7%20Coccidioidal%20meningitis&source=search_result&selectedTitle=1~10&usage_type=default&display_rank=1Royalty-free music used for this episode: Tropicality by Gushito, downloaded on July 20, 2023, from  https://www.videvo.net/

We had a late cancellation on a Chip Lunch guest but wanted to still bring you this episode of the Shock Absorber with our guest Jon Dunbier!-----------------------------------------------------------Jon Dunbier from Grace Anglican Church joins the podcast to discuss IGM and unintended consequences of a variety of church and cultural changes and the Frankenstein type church communities they often create.They again delve into creating Christian cultural goods whether that means teaching Christians to be resilient, making church exciting with those who are committed to be there or moving forward together under Christ instead romanticising about days gone by.They round up the episode with some quickfire practical advice thoughts around intergenerational ministry.00:00 Intro01:20 Soul Revival Church and Grace Church04:36 CULTURAL ARTEFACT: Faith, Hope and Carnage13:06 Causes and prevention of ministry drop off points37:51 Unintended consequences of church, culture1:03:03 Frankenstein church communities1:19:44 Sin is sin1:31:37 Quickfire practical adviceDISCUSSED ON THIS EPISODEGrace Anglican ChurchFaith, Hope and Carnage, by Nick Cave and Sean O'HaganBit of a Blur, by Alex JamesRadio Birdman

Are myths about vaccines and their DNA-altering capabilities clouding your judgement? Let us arm you with facts as we journey through the complexities of viruses and the marvels of modern immunizations. Together, we'll navigate the intricate relationship between these microscopic invaders and the defense mechanisms of our bodies. Expect a thorough examination of how vaccines employ fragments of a virus's spike protein to elicit an immune response, a giant leap from the days of using inactivated viruses. Our discourse aims to dismantle doubts and empower you with the confidence to champion the cause of vaccine safety and efficacy in your community.Our immune system is an unsung hero, and in this episode, we give it the spotlight it deserves. We'll explore the timeline of antibody production post-exposure, revealing the nuanced roles of IgM and IgG antibodies and the lasting protection they offer. We'll also discuss the valiant T cells and B cells, the architects of cellular immunity. By understanding how our bodies recruit these cells to fend off infections, you'll gain a newfound appreciation for the science behind the structure of antibodies and their vital role in our well-being.Taking a step back in history, we delve into the contributions of diverse communities in the realm of vaccines—an homage to the pioneers who laid the groundwork for today's medical miracles. But it doesn't stop there; we also gaze into the crystal ball of vaccine technology, discussing the groundbreaking potential of combined flu and COVID-19 vaccines and the promising advancements that could see vaccine development times slashed to mere months. This episode is not just a celebration of medical achievements; it's a testament to the collective power of communities, like the 2,000 Northeast Florida participants in vaccine trials, whose efforts fuel the relentless pursuit of health innovation. Join us for a riveting tale of human ingenuity and resilience in the face of disease.Be a part of advancing science by participating in clinical researchShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedIn Powered by ENCORE Research GroupMusic: Storyblocks - Corporate InspiredThank you for listening!

Esto es BlitzoCast. No es HistoCast pero casi. Tenemos que anunciaros que nos embarcamos en una nueva aventura, literalmente un viaje con los oyentes. Os lo cuentan David Arjona, @tamtamveramendi, @HugoACanete y goyix_salduero.

Ellen Vaughn is a New York Times bestselling author and speaker who has written or co-written twenty-four books. Former vice president of executive communications at Prison Fellowship, she collaborated with the late Chuck Colson on a number of his seminal works. She speaks at conferences, often travels to interview Christ-followers in hostile parts of the world, and serves on the board of directors for IGM, the global church developer. With degrees from Georgetown University and the University of Richmond, Ellen lives in northern Virginia and enjoys reading, hiking, drinking coffee with friends, and staring pensively at the ocean. Her latest book, Being Elisabeth Elliot will be available nationwide on September 12, 2023.Learn more here: https://ellenvaughn.com/Get my new book 'The Path of an Eagle: How To Overcome & Lead After Being Knocked Down'.► AMAZON US► AMAZON AUS► AMAZON UKCONNECT WITH JAY & THE STORY BOX► INSTAGRAM ► TWITTER ► FACEBOOK ► WEBSITE SUBSCRIBE FOR MORE! ► Apple Podcast ► Spotify ► YouTube Enjoying The Show? Consider Subscribing To YouTube & Apple Podcasts, Please Leave A 5-Star Rating and Review over on Apple Podcasts.► Support The Show Here:Support this show http://supporter.acast.com/thestorybox. Hosted on Acast. See acast.com/privacy for more information.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   John: Hello! Thank you so much for all the great teaching and helpful and healing information I've been listening for a couple years now and find your approach very balanced and inspiring! I am 37 years old 6'2 and weigh around 213lbs. I work my own business doing drywal work and wear a Fitbit that says I am usually doing around 20k steps a day. I just started the fatlossity program and I'm excited to see what it can do! I am wondering with such a physical labor job what is the balance to working out and resting? And what kind of macros such as protein grams should be my goal? According to my RenPho scale my body fat is 29%! BMR 1815, BMI 26.9, muscle mass 140lbs and has been for some consistent time. How do I loose the body fat and gain muscle while working so hard every day   Melissa: Hi Dr. Cabral, my IgG and IgM are low. Are there common reasons for this? I recently did your minerals & metals test and it said I have elevated levels of aluminum (.51) and mercury (.01). Could this be contributing? Does being pregnant affect the minerals results of this test at all? Also, I have mild Scoliosis and was wondering if you knew of any internal side effects that are common for people who deal with this condition? Could this be contributing to the low immune system issue? I am also wondering if there is anything I can do to excrete excess estrogen while pregnant or breastfeeding? I got melasma with my last pregnancy and breastfed for 21 months…my melasma has gotten progressively worse. I know there's not a lot you can do to detox when pregnant. Thanks!   Hannah: Hi, Dr. Cabral! You're truly a life saver. With more space in the description, I'd go on to say more but you and your team truly saved my life and I'm forever grateful….here's my question- I've tried your heavy metal detox but I always have reactions to the large amount of chlorella. I can have some in the DFVB but the heavy metal detox sets me over the edge. All of your protocols are absolutely amazing but sadly I need a replacement for a heavy metal detox that doesn't use chlorella, or at least smaller amounts. Does the Coseva Advanced TRS work as well as advertised? If you don't recommend that one, is there any others you would suggest? Thank you so much!   Luis: Hi Dr Cabral, what would you recommend for a dysfunctional ileocecal valve? I seem to have occasional pain or pressure on my lower right quadrant. Ileocecal release maneuvers and heated castor oil packs (which i use with dmso cream) seems to help relieve pain there,. I have been diagnosed with dyspepsia by my GI, and I seem to have SIBO-like symptoms. I have tried the CBO protocol but I still seem quite a bit of stomach pain and difficulties, especially if I eat the wrong foods. I should mention that I had a Parathyroidectomy about 2 months ago if thats relevant. Is there anything you can suggest or would this require some surgery? Thanks   Luis: Hi Dr Cabral, I wrote in yesterday regarding a dysfunctional ileocecal valve with pain and possible sibo/gi issues caused by it. I had forgotten to ask if a Liver & Gallbladder flush would be advisable if the valve is impeding bowel flow. It would seem to me that such an issue could also hamper the elimination of gallstones. I have done 8 over the course about 4 years but I still have poor elimination. The last elimination didnt yield that many gallstones. Can you please advise? I also take chlorophyll pills & peppermint oil. Also, one last question - I sometimes take enteric coated proteolytic enzymes as I've heard that such ileocecal valve issues can be caused by scar tissue. I'm not sure that its helping and I sometimes notice pills in my stool especially when its watery   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/2830 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Certainly, here are the show notes with the addition of research studies: Review of Bovine Colostrum: Let's begin by delving into what bovine colostrum (BC) is all about: Bovine colostrum is the initial milk produced immediately after birth, brimming with essential macro- and micro-nutrients, immunoglobulins, and peptides boasting antimicrobial properties and growth factors. Now, let's explore the potential advantages: Immune Support: Colostrum is abundant in immunoglobulins, particularly IgG, IgM, and IgA, which can fortify the immune system. Additionally, it contains lactoferrin, lysozyme, and other immune components that might aid in enhancing immunity. Gut Health: Colostrum is said to assist in maintaining a healthy gut lining. Its growth factors could contribute to the repair of damaged intestinal tissue and play a role in preserving gut permeability. Nutritional Content: Bovine colostrum is replete with proteins, vitamins, and minerals that can contribute to overall nutrition. Growth Factors: It encompasses various growth factors such as insulin-like growth factors (IGF-1 and IGF-2), transforming growth factors (TGF-alpha and TGF-beta), and epithelial growth factor (EGF), potentially promoting tissue growth and healing. Antimicrobial Properties: The presence of lactoferrin, lysozyme, and immunoglobulins in colostrum imparts antimicrobial properties, which may combat harmful bacteria and viruses. Athletic Performance and Recovery: Some athletes turn to colostrum supplements with the belief that it aids in recovery and enhances performance, although scientific evidence in this area is still evolving. Anti-inflammatory: Colostrum has been suggested to possess anti-inflammatory properties, potentially benefiting conditions involving inflammation. May reduce the risk of upper respiratory infections: Studies have indicated that athletes who consumed colostrum had fewer instances of upper respiratory infections compared to those who received a placebo. So, what does the research reveal? Processing and Heat Treatment: Processing and heat treatment, necessary for safety, can diminish the bioactive composition and the inhibitory and immunomodulatory capabilities of colostrum. Rich in Bioactive Components: Bovine colostrum is notably rich in biologically active peptides, antioxidants, anti-inflammatory agents, and growth-promoting factors, distinguishing it from mature milk. Intestinal Permeability Study: One study involving 12 athletes vulnerable to intestinal permeability due to intense exercise found that daily consumption of 20 grams of bovine colostrum prevented 80% of the increase in intestinal permeability experienced by those who received a placebo. (Reference: Trusted Source) Saliva IgA Antibodies Study: In a 12-week study with 35 adult distance runners, taking a daily bovine colostrum supplement increased saliva IgA antibodies by 79% compared to baseline levels. (Reference: Trusted Source) It's important to keep in mind that bovine colostrum supplements and powders can be relatively costly, ranging from $50 to $100 per 16 ounces (450 grams), with a typical daily dosage of half a teaspoon (1.5 grams). Additionally, the composition of bovine colostrum may vary depending on how the cows are raised, potentially containing antibiotics, pesticides, or synthetic hormones.

A Brooklyn és az OKC offszezonjait beszéltük át Igmándy Áronnal és Guber Péterrel. patreon.com/keletennyugaton Együttműködés: www.betonenetwork.hu Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 143: Pulmonary Cocci BasicsDr. Lovedip Kooner explains the history, diagnosis, and treatment of pulmonary coccidioidomycosis (cocci for short.) Disseminated cocci infection was also discussed. Dr. Arreaza added some anecdotes of patients seen with this infection.  Written by Lovedip Kooner, MD. Comments by Hector Arreaza, MD. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition:Coccidioidomycosis, also known as Valley Fever, is an infection caused by the fungi Coccidioides immitis and Coccidioides posadasii. Coccidioides is also referred to as cocci. Generally speaking, C. immitis is found in California and C. posadasii is found in Arizona, and Central and South America. More recently Cocci has also been found as far north as Washington and British Columbia. History:The fungal infection was first reported by Wernicke and Posadas in Argentina in 1892 where they described a case where a man had cutaneous cocci of the head, arm, and trunk. To this day, the head is preserved in Argentina. 4 For many years, only disseminated cases were recognized and described as “coccidioidal granulomas.” The work of Dixon and Gifford in 1935 elucidated that a pneumonic disease of unknown cause termed “San Joaquin Valley Fever” was, in fact, the primary coccidioidal infection and the port of entry of almost all coccidioidal disease. Initial infection occurs predominantly by inhalation of aerosolized arthroconidia and rarely by direct cutaneous inoculation.1,2Coccidioides spp. survive best in areas with low rainfall (12–50 cm per year), limited winter freezes, and alkaline soils. With climate change models, predicting the geographical range expansion.These dimorphic fungi exist in a mycelial form in the soil. Coccidioides species have been found in animal burrows near the Kern River and in Armadillo burrows in South American countries like Brazil. The mycelia produce arthroconidia (spores) that are ultimately airborne and inhaled.The inoculum required for infection is low and in animal models as few as a single arthroconidium may cause infection.3 Infection:Once arthroconidia are inhaled into the lung, there is typically a 1-3-week incubation period. The arthroconidia undergo morphologic changes into spherules, which are large structures that contain endospores.4 As spherules mature, they rupture and release endospores. Endospores can be spread hematogenous or through lymphatics to essentially any organ, leading to the development of new spherules and potentially disseminated disease.5 Not everyone who inhales the arthroconidia gets the infection. Clinical Manifestations.About 60% of patients who inhale arthroconidia are asymptomatic. 30% have a mild respiratory illness, like the flu. 10% have a more serious disease course and are diagnosed. Other symptoms may include fever, drenching night sweats, and weight loss. Extreme fatigue that limits baseline activity may also raise concerns. Symptom onset up to 2 months after endemic exposure should lead to coccidioidomycosis on the differential. Coccidioidomycosis cases have been documented in Michigan, Europe, and China. These cases were of people who traveled to endemic areas for as little as a few days and then were later diagnosed. 1-3% of all coccidioidomycosis cases are disseminated, severe, or chronic pulmonary infections. If undiagnosed, coccidioidomycosis may lead to significant morbidity and mortality. Dissemination sites include the skin, lymph nodes, bones, and Central Nervous System (CNS) which is the most severe. Any organ can be infected, including documented cases of the prostate and adrenal gland. Arreaza: Recap: 60% are subclinical, 30% are mild, 10% serious, 1-3% are disseminated. What are some risk factors for severe infection? Should I stop biking?Risk factors for severe infection:Severe pulmonary infections can happen in anyone but occur more commonly in diabetics, tobacco users, and people older than 65 years of age.Oceanic or Filipino ethnicity and black or African American have a higher rate of dissemination. Immunosuppression, including HIV, transplant patients, and immunosuppressive medications like corticosteroids or TNF-alpha inhibitors have been shown to be risk factors for dissemination. Pregnant patients, particularly in the third trimester have higher rates of severe infection as well.Arreaza: How do we diagnose the disease?Diagnosis:Diagnosis is commonly made serologically. EIA (enzyme immunoassay) is used more often. There are more false positives than false negatives and varies by manufacturer. Kern County Health Department uses Immunodiffusion IgG and IgM and Complement Fixation are used. Immunodiffusion IgG and IgM are scaled by non-reactive, weakly reactive, reactive and strongly reactive. Compliment fixations are scaled by a ratio/dilution. Serum Compliment fixations

Meet the father and daughter team of the industry- Amanda and Mike Fontaine from The Ledges Golf Club in South Hadley, Massachusetts. These two golf course superintendents have enjoyed a lot of recognition recently after being featured in several industry publications. Mike has been on the property for 23 years and recently moved into the role of General Manager. This change presented him with the opportunity to offer his daughter the position of Golf Course Superintendent. Amanda grew up on the golf course and remembers playing in the bunkers and then having to rake them when done! She talks about the challenges of being not only a young superintendent, but the daughter of the GM. She also gives us great insights into how she runs the show, her challenges agronomically, and makes a point of not being afraid to ask questions. Mike and Amanda talk about the challenges of finding and maintaining labor in a market where golf rounds are up and wear and tear on the property is worse than ever. They work for IGM, a management company, on a course that is owned by the town of South Hadley, MA and discuss how that affects day to day operations. It is so refreshing to hear a father and daughter team talk with passion about the golf course and the industry.Visit EarthWorks at: https://www.earthworksturf.com Podcasts: https://www.earthworksturf.com/earthworks-podcasts/ 2 Minute Turf Talks: https://www.earthworksturf.com/2-minute-turf-talks/

In this episode, Cara and Missi outline the TORCH infections and considerations for the antepartum period and the newborn. TORCH can have serious implications during the neonatal period. Passing the TORCH will remind you about IgG and IgM, symptoms to look for, and risk factors that may contribute to infections. #TORCHinfections #cytomegalovirus #rubella #herpes #toxoplasmosis #parvovirus #COVID #zika #syphillis #neonataloutcomes #MFM

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Lindsey: Hello Dr. Cabral, I would love to pick your brain on a controversial Vitamin D question. I have always followed the integrative/holistic/naturopathic view on Vitamin D and the idea that low levels can be part of the chain reaction of root cause issues for many dis-eases of the body. However, I recently listened to a XXXXX podcast episode with XXXX about Vitamin D levels and supplementation that made a lot of sense even though it contradicts everything every respected Integrative doctor has ever thought about vitamin D. If you are familiar with his explanation, I'd love to hear your thoughts. If not, it's a suggested conversation topic for a future episode vastly different than the other vit d podcasts in the past.   Lindsey: Hello again Dr. Cabral - one more question to have a conversation about. I am breastfeeding and I wonder about future autoimmune issues for my baby. If I comprehend the autoimmune theory correctly, when the gut is leaky, proteins cross the lining and the body sees them as invaders creating an autoimmune response that expresses in the weak part of your individual body. This is very simplified. Since babies are born with permeable guts, can proteins go through my milk to do this. I am specifically worried because I have MODY or Type 1.5 diabetes. Since dairy in babes can cause type 1 diabetes, if I eat dairy will that do the same through my milk for the baby? What about allergen introduction? They suggest to do the big 9 within the first year. If one is a trigger, will it create AI?   Caitlin: I will try to keep this short: How do I know if I am suffering from candida overgrowth or just have a lot of the common symptoms of it for different reasons? I have severe eczema/dermatitis on my hands. I have suffered from this for years, on and off. I am working in a restaurant again, which has worsened it, but I know that my poor gut health in the past has played a role and steroid withdrawal. have for the last year and a half took major steps to improving my health Basically, I have the skin issues, I have yeast infections sort of often, and now I am experiencing dry scalp. Could this just be a few things happening at once and because it's winter? (I live in New York). I'm sorry for the lengthy message and understand if you can't answer on the podcast. Thank you for all you do.   Ales: Hello Dr. Cabral. I am an Integrative Health Practitioner L2, and I have question regarding food sensitivity testing. There seems to be newer version of testing called MRT (Mediator Release Test), which unlike IgG (testing for only type III sensitivity), is testing for type IV sensitivity. They claim that when the T-cells identity a food as harmful, they release mediators such as cytokines, histamines, and prostaglandins, causing inflammatory symptoms. Since MRT apparently measures the release of mediators from WBC and these mediators are proinflammatory chemicals, which leads to chain immune reaction, wouldn't it a much more accurate way to test for food sensitivities? Thank you for your thoughts..   Melissa: Hi Dr. Cabral - I've been working with a local functional medicine doctor and I found out I have 2 MTHFR gene mutations, high estrogen (testosterone and progesterone look good), high cortisol, APOE3/E4, low dopamine, high oxidative stress, AA/EPA is high, low MCHC, a marker for celiac disease, strep in my gut (no parasites) and my IgG and IgM are both very low. My FM dr is telling me to find an immunologist. I'm thankful to have all of this information but I'm feeling overwhelmed. I wanted to reach out for any specific advice you can provide with this info (nutritionally, testing, exercise, etc). Are there certain foods I shouldn't eat with MTHFR gene mutation or high estrogen? Thank you   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/2648 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

My guest this week is Amy Jaramillo, Scientific Director of BodyScience. In this episode, Amy and I discuss her scientific approach to looking at diseases and the body. Her goal is to get to the root cause of health issues. She looks at health through a different kind of scientific lens where she is able to look at patterns and see the body as a puzzle. We talk about how her and her team treat underlying infections and reverse diseases such as ALS. Even if you are well versed in infections this episode covers a lot. Lastly, no episode would be complete without touching on one of our favorites–peptides. Amy Jaramillo is the Founder of Body Science LLC, a science based medical center developed with a mission to identify the root cause of health syndromes.  We identify the triggers, exposures and genetic predispositions responsible for conditions including: Motor Neurone Disease, Thyroid Dysregulation, Adrenal Fatigue, ADD/ADHD, Auto-Immunity, Diabetes, Leaky Gut, and Infertility and then we correct them.  Our goal is to cure, not merely to medicate.  A graduate of Florida State University with a B.S. in Biology and Chemistry, Amy has over 21 years of experience in the healthcare industry. She is a member of the American Academy of Anti -Aging (A4M) since 2011 and a past member of the Association for the Advancement of Restorative Medicine (AARM).  Amy has extensive experience working in the fields of bio-genetics and bio-technology understanding the genetics-disease link as well as in the field of brain stimulation, implantation and neuromodulation for neuro-degenerative disease.   Follow Amy: www.bodyscience.life  ALS-Bodyscience MTHFR experts   ------     Episode Sponsors Mitopure is a scientific breakthrough for our cells. Ten years of research has led to the discovery of Urolithin A. Urolithin A is a mitochondrial powerhouse and assists in mitophagy. By supporting mitophagy we can protect cells from cellular decline. Mitopure is clinically proven to enhance muscle health and performance. It comes in a powder, capsules or a berry powder. There is a three month trial so you can try them all! Use code NAT10 for 10% your order! Oxford HealthSpan brings us Primeadine, the best formulated Spermidine supplement on the market!  What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine!  I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”.  Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin and nails! Oxford HealthSpan is now offering gluten-free Primeadine! Sponsor offer: If you haven't tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15% of your first order at https://oxfordhealthspan.com/products/best-spermidine-supplement.      ------     Episode Takeways [08:00] About Amy [13:00] Reactivation of infections due to COVID? [15:40] EBV a cause of MS? [21:39] What is the difference between IgM and IgG? [29:25] ALS reversal [42:00] Herxing: Is that what is causing symptoms or something else? [58:40] The role that heavy metals play in viruses [69:49] Should you start with viral screening when first assessing a patients' symptoms? [78:27] Peptides for infections [92:07] What is the first symptom that improves when someone's health is taking a turn for the better? [96:50] Parting words of wisdom     Follow Nat Facebook Facebook Group  Instagram Mighty Networks BSP Community Work with Nat: Book Your 20 Minute Optimization Consult

In this episode, Coleman I. Smith, MD, and Lydia Tang, MBChB, discuss how to screen for hepatitis delta virus (HDV), including:Algorithm for evaluation of HDVDiagnosis of different stages of HDV infection Strategies to increase HDV testing rates Faculty:Coleman I. Smith, MDProfessor of MedicineHepatologistGeorgetown Transplant InstituteGeorgetown UniversityWashington, DCLydia Tang, MBChB Assistant ProfessorDepartment of Infectious DiseasesUniversity of Maryland School of MedicineInstitute of Human VirologyBaltimore, MarylandLink to full program:http://bit.ly/41oYawrFollow along with the slides at: http://bit.ly/3XW6m4g

In this VETgirl online veterinary continuing education podcast, we discuss a point-of-care (POC) antibody assay for Coccidioides in dogs. Coccidioides is a systemic fungal infection also known as Valley Fever, common in the southwest United States and parts of northern Mexico (Brown). The fungal organisms live in the soil, but unfortunately can become aerosolized and inhaled, leading to disease. Affected dogs often suffer from respiratory disease, but a quarter of cases can result in more serious, disseminated infections (Davidson). In a study entitled "Clinical performance of a point-of-care Coccidioides antibody test in dogs" by Reagan et al, the authors dive into the diagnostic options available for detecting Coccidioides, and they offer a quick and helpful review of the available options. Briefly, several diagnostic options are available, though cytology, histopathology, or fungal culture represent the gold standards. An agar gel immunodiffusion (AGID) assay is used commonly in dogs to detect IgM or IgG against fungal antigens, but this test is expensive, has certain technical challenges, and varies in performance. Additionally, an enzyme immunoassay can also be performed for rapid antibody detection, but this assay still requires sending samples to a reference laboratory. Lastly, an immunochromatographic lateral flow assay (LFA) is another type of rapid detection assay that detects antibodies against two Coccidiodies antigens. This is a POC test that can be performed in approximately 30 minutes! Therefore in the current study, the authors sought to determine the agreement between this LFA and the standard AGID assay in dogs with suspected coccidioidomycosis.