Podcasts about Ige

strategy practical adult diagnosis pitfalls allergy primary care food allergies management strategies ige

Play Episode Listen Later Feb 5, 2026 28:27

Nearly 11% of U.S. adults meet criteria for a convincing food allergy, yet most clinicians underestimate both the prevalence and unique challenges of adult-onset disease. This episode addresses the frequent misdiagnosis and clinical uncertainty surrounding new symptoms in adults by highlighting epidemiology, risk factors for delayed and severe reactions, high-yield history-taking, diagnostic pitfalls, and guideline-supported use of specific IgE and component-resolved diagnostics. Listeners will learn to distinguish allergy from intolerance, understand psychosocial burdens, apply evidence-based testing algorithms, and recognize when to refer for oral food challenge or advanced management. With practical insights into differential diagnosis, best practices for test interpretation, and strategies to streamline care in busy settings, this episode equips providers to close the adult allergy diagnosis gap and optimize patient safety. Resources and references: https://www.thermofisher.com/phadia/us/en/resources/immunocast/adult-onset-food-allergy-diagnosis-management.html?cid=0ct_3pc_05032024_9SGOV4

The many faces of milk problems

The Allergist

Play Episode Listen Later Feb 3, 2026 29:17 Transcription Available

“There is nothing magical that happens in your gut that says, ‘oh, now you're ready for cow's milk.' — Dr. Farah KhanMilk has a special talent for creating chaos in clinic. One day it's mucousy stools and a terrifying diaper photo, the next it's hives after yogurt, delayed vomiting with lethargy, or a family that's been dairy-free for years with no improvement in eczema. On this episode, Dr. Mariam Hanna is joined by pediatric allergist and clinical immunologist Dr. Farah Khan to walk through the many ways “milk problems” show up — and how allergists can avoid overdiagnosis, unnecessary testing, and prolonged elimination diets that may do more harm than good.On this episode:Why allergic proctocolitis (cow's milk protein intolerance) is often overdiagnosedWhen skin testing and IgE testing are useful Understanding the difference in lactose intolerance How baked milk can be used to improve quality of life in IgE-mediated milk allergyWhat makes FPIES to milk tricky, including earlier-than-expected reactionsWhy dairy elimination for eczema or EOE needs caution and frequent reassessmentAcross each of these scenarios, Dr. Khan returns to the same principle: eliminating dairy should never be a one-and-done decision. Revisiting the diagnosis, retrying thoughtfully, and weighing quality of life alongside risk are essential — especially when prolonged avoidance can set the stage for the very allergy clinicians are trying to prevent.Have an idea for the show or a comment, send us a text!Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions

medicine milk physicians khan allergy immunology medical education many faces ige allergic reactions canadian society eoe farah khan fpies

83. When Healing Your Gut Isn't the Answer

The Dr. Terri Show

Play Episode Listen Later Jan 20, 2026 39:41

"It's not really true that if you just fix your gut, you're fixing everything." If you have eczema, psoriasis, rosacea, or hives and nothing seems to work... if you've tried every elimination diet and "heal your gut" protocol only to see your skin get WORSE... if you've bounced from functional doctor to functional doctor without answers... this episode changes everything.Dr. Terri sits down with Jennifer Fugo, a clinical nutritionist who specializes exclusively in chronic skin conditions (and host of the Healthy Skin Show podcast with nearly 400 episodes), for one of the most eye-opening and controversial conversations about skin health you'll ever hear. This isn't your typical "just heal your gut" advice - it's the truth about why that approach FAILS for most people with skin issues and what actually works. WHAT YOU'LL DISCOVER: → Why "heal your gut" advice is incomplete and does a MASSIVE disservice to skin patients → The shocking truth: elimination diets can cause IgE anaphylactic food allergies in adults → Why you're bouncing from practitioner to practitioner and getting worse, not better → The Phase 2 liver detox pathway that 99% of practitioners overlook→ How milk thistle and dandelion root could be making your skin WORSE (ragweed allergens) → The cross-reactive allergen problem that practitioners don't check for → Why food is just a Band-Aid (not the root cause) for most skin conditions This isn't about ONE thing fixing everything. It's about finding YOUR root cause combo. ---TIMESTAMPS: 0:00 - Intro 1:30 - Jennifer's eczema story (and why it sparked her mission) 4:20 - Why skin issues are different than "hidden" conditions 6:15 - The "heal your gut" myth that's failing patients 7:45 - Why people bounce between practitioners getting worse 10:30 - It's not ONE thing - it's multiple root causes 12:15 - The Phase 2 liver detox pathway everyone overlooks 14:40 - Why milk thistle might be making you worse 17:20 - The glycine secret for liver support 20:15 - Cross-reactive allergens practitioners don't check 25:30 - Rosacea and stomach acid connection 30:55 - Demodex mites and rosacea (what to ask your doctor) 33:10 - How to advocate for yourself in limited appointment times 37:00 - The elimination diet danger (developing anaphylactic allergies) 41:30 - Food is a Band-Aid, not the cure ---RESOURCES MENTIONED:• The Healthy Skin Show Podcast https://www.skinterrupt.com/listen/ • Jennifer Fugo's Practice https://www.skinterrupt.com/book-a-session/ • Evexias Health Solutions (Episode Sponsor) Website: https://www.evexias.com Find a provider near you ---SUBSCRIBE for more episodes challenging conventional health wisdom and exploring what ACTUALLY works.If this episode gave you answers you've been searching for, LIKE and SHARE it with someone struggling with chronic skin conditions.COMMENT below: Have you been told to "just heal your gut" for your skin? What happened? ---ABOUT THE DR. TERRI SHOW:Dr. Terri brings you honest conversations about health, wellness, personal transformation, and the topics that matter most in today's world. From integrative medicine to nutrition to policy reform, we explore it all with expert guests who are making a real difference.New episodes weekly. Subscribe and turn on notifications so you never miss an episode. ---The Dr. Terri Show is presented by Evexias Health Solutions. For more, visit: https://www.evexias.com Connect more with Dr. Terri:

practice food cross massive phase worse fails band aids ige rosacea healing your gut jennifer fugo demodex

Eczema Essentials: Diagnosing and Managing Atopic Dermatitis in Practice

practice managing essentials references clinicians diagnosing eczema ige atopic dermatitis

Play Episode Listen Later Jan 20, 2026 30:30

For primary care providers, seeing a patient presenting with atopic dermatitis (eczema) is common, yet misconceptions persist regarding its underlying cause and optimal management. This episode tackles the critical clinical dilemma: when and how should specific IgE testing for food and environmental allergens shape routine eczema care? Key topics include the evolution of pathophysiology—shifting focus from allergy-driven disease to barrier dysfunction and type 2 inflammation—plus risk stratification, differential diagnosis, the role and interpretation of specific IgE tests, evidence-based guideline updates, environmental and food allergen impacts, targeted therapeutics, and practical patient counseling. Special attention is given to environmental triggers such as dust mites and pet dander and structured elimination diets. Clinicians will gain actionable insights on refining diagnostic workups, individualizing treatment plans, and supporting long-term disease control in pediatric and adult eczema populations. References and resources: https://www.thermofisher.com/phadia/us/en/resources/immunocast/eczema-essentials-atopic-dermatitis-diagnosis-management.html?cid=0ct_3pc_05032024_9SGOV4

Episode 244: What the Medical Approach Is Missing When It Comes to Eczema & Allergies

Natural Super Kids Podcast

Play Episode Listen Later Jan 18, 2026 24:20

Why Managing Symptoms Isn't Enough for Kids With Eczema and AllergiesThis week on the podcast, we're continuing our eczema and allergies series with topic two and it's a juicy one! This time, we're talking about something so many parents feel in their bones but don't always have the words for: when it comes to eczema and allergies, why does it feel like we're constantly managing symptoms… but rarely getting real answers?

missing medical relief vitamin d allergies probiotics klub eczema ige immune support healthy microbiome

Organoids and Assembloids Revolutionizing Pain Research, Mitochondrial Transfer for Peripheral Neuropathy, and Parkinson's Disease Iron Misconceptions

Ask Doctor Dawn

Play Episode Listen Later Jan 17, 2026 54:03

Broadcast from KSQD, Santa Cruz on 1-15-2026: An emailer from Switzerland asks about fluorescein angiography requested before her first retina appointment. Dr. Dawn suspects protocol-based medicine screening for macular degeneration and suggests negotiating to see the doctor first given her different reason for seeing a retinal specialist. She encourages patients to maintain agency in medical settings. An emailer asks about creatine supplements. Dr. Dawn notes it helps muscle development in people doing weight training at 3-5 grams daily, but does nothing for aerobic-only exercisers. Claims about cognition and mood lack solid research. She advises against high-dose "loading," and cautions that creatine causes fluid retention problematic for congestive heart failure and should be avoided with stage 3 or higher kidney disease. Dr. Dawn reminds listeners it's not too late for flu shots, noting this season's H3N2 strain emerged after vaccine formulation was finalized. She laments mRNA vaccine research defunding, as that technology allows rapid reformulation. She describes organoids—tissues grown from stem cells that self-organize into primitive organ structures, enabling rapid drug screening without animal testing. Stanford researchers created assembloids by placing four neurological organoids together that spontaneously connected and built the ascending sensory pain pathway, offering new approaches to studying chronic pain. Dr. Dawn explains research showing satellite glial cells transfer healthy mitochondria to spinal sensory neurons through tunneling nanotubules. When this transfer fails, neurons fire erratically causing pain. Infusing healthy mitochondria into mouse spinal columns cured peripheral neuropathy—suggesting future periodic infusion treatments for humans. She reports Texas A&M researchers created "nanoflowers" from molybdenum disulfate that double stem cell's mitochondrial production, potentially supercharging regenerative medicine for conditions including Alzheimer's and muscular dystrophy. A caller asks about flu vaccines with egg allergy. Dr. Dawn explains that his gastrointestinal reactions to eggs differ from dangerous IgE allergies causing hives or anaphylaxis—GI intolerance doesn't preclude vaccination. Dr. Dawn reveals that 20 years of Parkinson's research followed a false lead. MRI showed increased iron in patients' brains, prompting iron chelation trials—which worsened symptoms. The problem: MRI detects paramagnetic ferric iron (stored, inert) not ferrous iron (biologically active). Patients accumulate useless ferric iron but are deficient in usable ferrous iron. Earlier 1980s studies showing that iron supplementation helped were ignored and abandoned prematurely. She suggests Parkinson's patients discuss iron supplementation with neurologists. She will post the link in the resources page on her website. A caller concerned about early Parkinson's describes tremors and balance problems in darkness. Dr. Dawn suggests darkness-related symptoms sound more like peripheral neuropathy than Parkinson's, recommending neurological examination and screening for diabetes, B vitamin deficiency, or heavy metal exposure. She confirms that sedentary lifestyle reduces mitochondrial production while progressive exercise builds both muscle and mitochondria.

Cientistas franceses desenvolvem vacina para evitar reações alérgicas graves

Saúde

Play Episode Listen Later Jan 13, 2026 7:23

De acordo com a Organização Mundial da Saúde (OMS), cerca de 50% da população mundial terá algum tipo de alergia até 2050. Algumas delas geram reações graves e podem provocar um choque anafilático, potencialmente fatal. Para preveni-lo, uma equipe de cientistas franceses testou, com sucesso, uma vacina terapêutica contra as alergias. O resultado foi publicado recentemente na revista científica Sciences Translacional Medicine. Taíssa Stivanin, da RFI em Paris O estudo durou sete anos e foi realizado por uma equipe de cientistas franceses. De acordo com o cientista Pierre Bruhns, do Instituto Pasteur em Paris, que conduziu a pesquisa ao lado do pesquisador Laurent Reber, as alergias respiratórias ou alimentares são desencadeadas por um mecanismo de “reconhecimento” entre alérgenos e proteínas presentes na superfície das células, conhecidas como IgE, ou imunoglobulinas E. Esses anticorpos são produzidos por células do sistema imunológico chamadas plasmócitos. A maior parte dos IgE se fixa nos mastócitos — células do sistema de defesa presentes na pele — e nos basófilos, um tipo de leucócito, ou glóbulo branco, existente no sangue. A reação entre os alérgenos e os IgE provoca as alergias, que podem ser localizadas ou generalizadas, gerando um choque anafilático. “A vacina possibilita ao indivíduo, ou ao organismo que estamos imunizando, a criação de anticorpos dirigidos contra as IgE e o bloqueio dessas IgE, antes que elas consigam se fixar nos mastócitos ou basófilos. Esse é o princípio da vacinação”, diz. “Então, se o paciente é alérgico a várias substâncias, a vacina poderá protegê-lo de vários alérgenos de uma vez.” Atualmente, o único tratamento que previne as reações graves é o omalizumabe, que fornece ao paciente anticorpos para bloquear as IgE. O medicamento existe há 20 anos e é injetado no hospital. O efeito é longo, garantindo o conforto do paciente. Mas a 'logística' é complexa, sobretudo para pessoas que vivem longe dos estabelecimentos. “Em vez de fazer as pessoas irem ao hospital para tomar uma injeção desse anticorpo, propomos vaciná-las com duas ou três doses e, após dois ou três anos — talvez até mais — elas vão ficar livre do medicamento e continuarão protegidas das alergias.” Sem prevenção e, em caso de choque anafilático, o único tratamento possível contra a reação alérgica grave é a injeção de adrenalina, lembra o pesquisador do Instituto Pasteur. “O choque anafilático provoca uma parada cardiorrespiratória, e a adrenalina faz com que o pulmão volte a funcionar normalmente. Ela funciona muito bem quando é administrada precocemente, mas, se for dada tarde demais, o paciente pode sofrer uma alergia grave, até mortal”, ressalta. Terapia foi testada em camundongos No laboratório, durante os sete anos de pesquisa, a nova terapia foi testada em camundongos. “O camundongo é resistente ao desenvolvimento de alergias. O modelo que podemos utilizar em laboratório para que eles se tornem alérgicos não é, em regra geral, dependente da ação das imunoglobulinas E, como nos humanos”, explica Pierre Bruhns. A equipe precisou, então, adaptar o sistema imunológico dos animais para desencadear reações alérgicas semelhantes às que ocorrem em humanos e provar a eficácia da vacina terapêutica. “Injetamos IgE humanas diretamente nos camundongos para sensibilizá-los, como nos humanos. Em seguida, vacinamos os camundongos e injetamos os alérgenos, que vão interagir com as IgE. É como se estivéssemos imitando a reação alérgica no homem, sem que o camundongo precisasse produzir sua própria imunoglobulina E.” Nos animais, as vacinas forneceram proteção de 100% contra alergias durante um ano, o que equivale à metade da vida de um camundongo. A expectativa é que, no homem, essa proteção dure mais tempo — até dez anos —, algo que só poderá ser estabelecido após os ensaios clínicos. Mas, antes, será feita a análise da toxicologia da vacina e de seus possíveis efeitos colaterais, como exige a regulamentação europeia. Essa etapa será conduzida pela empresa Neovacs, que decidirá, em seguida, se é necessário validar o estudo em primatas. Só então o medicamento-candidato poderá ser testado no homem. A equipe também desenvolve, paralelamente, uma vacina que impedirá crises graves de asma. “De modo geral, a vacinação contra alergias respiratórias e alimentares está progredindo, e a gente faz o que pode para obter soluções clínicas. Esperamos obter as autorizações para realizar os testes em humanos e para a comercialização.”

nos ent esse mundial ela graves sem terapia evitar organiza algumas oms esses pesquisa atualmente vacina rfi ige cientistas franceses pariso instituto pasteur

244: What Is FPIES? // The Food Allergy Most Parents Haven't Heard Of

Paige Talks Wellness

Play Episode Listen Later Jan 7, 2026 21:34

As parents, we expect the occasional food reaction. Maybe a rash, some fussiness, or a tummy ache. But what happens when your child suddenly becomes violently ill hours after eating something they've had before, and no one seems to know why? That was my reality when Jasper had this kind of reaction to shrimp. Inside this episode, I'm digging into: What FPIES is and how it differs from IgE-mediated food allergies Common trigger foods and why reactions can show up hours later Our experience with Jasper's shrimp reaction (and what we learned from it) How to navigate fear around food after a reaction Why trusting your instincts and advocating for your child matters --- Show Notes: Sign up for a 1:1 Discovery Call Join the Imperfectly Paige Wellness Community Join the Compass Method DIY Program Jump inside my Rock the Bloat Minicourse Get my Core-Gi Workout Program with the exclusive listener discount! Join my Brain Rewiring Masterclass You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

rock parents heard allergy food allergies ige fpies

Episode 36 - Hives, Lesions and Lumps; Urticaria in Horses

The Skin Flint Podcast

Play Episode Listen Later Jan 7, 2026 38:27

Episode Overview Join us as we venture into the stables to explore urticaria in horses - those mysterious swellings that appear seemingly out of nowhere and may disappear just as suddenly. Expert guest Dr. Valerie Fadok shares her extensive experience as both a veterinary dermatologist and immunologist to help us understand what causes these puzzling conditions, how to differentiate them from other lumps, and when to investigate further rather than automatically reaching for steroids. Featured Guest Dr. Valerie Fadok - A dual specialist bringing unique expertise as both a veterinary dermatologist and immunologist. With experience across three veterinary schools, private practice, and as a field specialist with Zoetis, Val brings a wealth of practical knowledge from working with veterinarians and horse owners around the world. Episode Breakdown Introduction to Urticaria in Horses Val discusses how horses are the most commonly affected species with urticaria among the animals veterinarians treat, and how this condition can drive both horses and their owners to distraction. The disease presents unique challenges, with sudden onset cases that sometimes resolve on their own, and chronic cases where horses experience repeated outbreaks over time. Clinical Presentation and Diagnosis What Urticaria Looks Like: Val emphasizes the importance of palpation—urticarial lesions tend to be soft compared to nodular diseases like eosinophilic granulomas Individual lesions wax and wane, even if the horse has hives every day Lesions can take fascinating shapes: round, linear, or ring-like configurations (serpiginous patterns) Not all horses with urticaria are particularly itchy Papular Urticaria: Papular (miliary) lesions are commonly associated with insect bites Val shares examples of horses moving from northern US states to Florida developing papular urticaria in their first year due to high insect pressure from mosquitoes and Culicoides These cases often resolve after the first year Sue confirms similar patterns in the UK with Culicoides Immunological vs Non-Immunological Reactions The Role of Mast Cells: Urticaria involves mast cells in the skin Immunological urticaria occurs when allergens bind to IgE on mast cells, triggering the reaction Non-immunological causes involve "twitchy" mast cells that react to physical triggers Physical Urticaria: Pressure urticaria and dermatographism—where a handprint appears on the horse's flank after touching Cold-induced urticaria Heat-induced urticaria Exercise-induced urticaria Some horses have both immunological and physical components, making diagnosis particularly challenging History is Key: Observant owners can provide crucial information (e.g., "hives appeared after training session" or "outline of saddle appeared after removal") Owner observations are often the best way to differentiate between causes Acute vs Chronic Urticaria Acute Urticaria Management: Most acute urticaria in horses is drug-related (antibiotics, pain medications) or from blood transfusions Val's approach: Don't do an intense workup immediately Treat with antihistamines (Val prefers hydroxyzine) for a few months to let mast cells settle If it recurs after stopping medication, then investigate further Sue agrees: not chronic unless present for 8+ weeks or recurring annually When to Investigate: Sue and Val agree: 8-12 weeks or recurrent episodes warrant deeper investigation Both emphasize the value of owners who keep detailed calendars noting when hives appear 50% of urticaria in people remains idiopathic—same often true for horses Competition horses present particular challenges due to medication restrictions Investigation and Testing Seasonal Cases: For seasonal urticaria, Val recommends intradermal or serum allergy testing Horses with urticaria respond well to allergen immunotherapy compared to other species Most horse owners are comfortable giving injections Non-Seasonal Cases: Consider dietary factors and whether feed changes throughout the year Horse owners are surprisingly open to food trials Val has only proven a handful of food-related urticaria cases (alfalfa and grains) Diet trials are difficult in horses, though owners are willing Environmental Allergens: House dust mites and storage mites are the most commonly identified allergens across all species Molds are important triggers, especially in humid environments Val notes regional differences: Florida has unusual pollens and insects, Texas is drier with mainly pollens, Pacific Northwest sees more mold allergies Sue observes autumn cases in UK when horses start wearing rugs, potentially related to house dust mites, temperature, dampness, or molds Allergen-Specific Immunotherapy Val's Approach: Uses traditional step-up procedure for injection immunotherapy Consults pollen charts (from Greer allergy company, pollen.com, Google searches) Selects major allergens relevant to the horse's region and history Doesn't include everything that tests positive—focuses on major allergens that fit the history Builds up from 2-3 injections per week to maintenance (once weekly to once monthly, depending on the horse) Customization is Key: Frequency depends on individual horse response Traveling horses present challenges (Val shares experience with a Budweiser Clydesdale that traveled nationwide) For traveling horses, select major allergens common across regions (cedar trees, ragweed, common grasses) Seasonal Management: Val prefers to wait until the season is over before starting immunotherapy Aims for at least 6 months of treatment before the next allergy season Backs off frequency during off-season (e.g., monthly injections) Increases frequency during active season (weekly if needed) Never stops completely during off-season to avoid starting over Sometimes "less is more"—half a milliliter every two weeks may work better than full dose every four weeks Success with Horses: Horses respond particularly well to immunotherapy compared to other species Dedicated horse owners are excellent at fine-tuning treatment based on their horse's patterns Flexibility is key: can adjust dose and frequency as needed Treatment Options Antihistamines: Val's preference: hydroxyzine (though colleague Stephen White prefers doxepin) First-line treatment when possible Corticosteroids: Most US equine vets prefer dexamethasone (less expensive) Val prefers prednisolone (learned from equine mentor at Texas A&M) Alternate-day prednisolone is useful approach Long-term dexamethasone is concerning—if needed, aim for every 3-4 days For competition horses, medication restrictions are a major consideration Off-Label Options: Apoquel has helped some difficult cases when antihistamines and steroids aren't sufficient Very expensive and off-license (requires justification) Not on horse competition drug registers (as of recording) Can be useful short-term, such as before shows Not a long-term solution Long-Term Outlook Realistic Expectations: Flares will likely be part of life even with successful immunotherapy Stress can trigger urticarial eruptions (similar to people) Hope is to avoid year-round medication, but some horses require continuous treatment for comfort Some owners relocate horses from high-allergen areas (e.g., Florida/Southeast) to northern states Education Needs: Val sees room for growth in equine veterinary use of immunotherapy Cautions against testing too early (not after just one outbreak) Healthy animals can make IgE without it being clinically relevant Need for education on proper use of testing and setting realistic expectations Horse Owner Compliance Both Val and Sue emphasize how remarkably compliant and dedicated horse owners are: Horse owners will food trial willingly Will shampoo horses twice weekly in freezing weather Keep detailed records and calendars Are observant about patterns and triggers Are open to considering food allergies Follow through consistently with immunotherapy protocols The bond between pleasure horse owners and their horses makes treatment particularly rewarding Key Takeaways Palpation matters - Soft lesions that wax and wane suggest urticaria over other nodular diseases Don't over-investigate acute cases - Wait 8-12 weeks or for recurrence before extensive workup History is everything - Detailed owner observations are invaluable for diagnosis Horses respond well to immunotherapy - Better success rates than many other species Flexibility in treatment - Adjust immunotherapy frequency and dose based on individual response 50% remain idiopathic - Many cases resolve without identifying the cause Horse owners are exceptional - Compliance and dedication make management possible

texas google uk healthy owner horses diet soft expert pacific northwest compliance increases detailed customization hives ige lumps lesions zoetis urticaria stephen white clinical presentation selects

karácsonyi idő Karácsony 2. vasárnapja| Jn 1,1-18 |

Napi evangélium

Play Episode Listen Later Jan 4, 2026 15:47

Kezdetben volt az Ige, az Ige Istennél volt, és Isten volt az Ige, ő volt kezdetben Istennél. Minden általa lett, nélküle semmi sem lett, ami lett. Benne az élet volt, s az élet volt az emberek világossága. A világosság világít a sötétségben, de a sötétség nem fogta fel. Föllépett egy ember, az Isten küldte, s János volt a neve. Azért jött, hogy tanúságot tegyen, tanúságot a világosságról, hogy mindenki higgyen általa. Nem ő volt a világosság, csak tanúságot kellett tennie a világosságról. (Az Ige) volt az igazi világosság, amely minden embert megvilágosít. A világba jött, a világban volt, általa lett a világ, mégsem ismerte föl a világ. A tulajdonába jött, de övéi nem fogadták be. Ám akik befogadták, azoknak hatalmat adott, hogy Isten gyermekei legyenek. Azoknak, akik hisznek nevében, akik nem a vérnek vagy a testnek a vágyából s nem is a férfi akaratából, hanem Istentől születtek. S az Ige testté lett, és közöttünk élt. Láttuk dicsőségét, az Atya Egyszülöttének dicsőségét, akit kegyelem és igazság tölt be. János tanúbizonyságot tett róla, amikor azt mondta: „Ez az, akiről hirdettem: Aki nyomomba lép, nagyobb nálam, mert előbb volt, mint én.” Mindannyian az ő teljességéből részesültünk, kegyelmet kegyelemre halmozva. Mert a törvényt Mózes közvetítette, a kegyelem és az igazság azonban Jézus Krisztus által lett osztályrészünk. Istent nem látta soha senki, az Egyszülött Isten nyilatkoztatta ki, aki az Atya ölén van. Olvasmányok, ünnepek a liturgikus naptárban. | Felolvassa: Varga László |

nem ez aki minden mert ige isten benne krisztus mindannyian kezdetben

karácsonyi idő karácsony nyolcada, 7. nap| Jn 1,1-18 |

Napi evangélium

Play Episode Listen Later Dec 31, 2025 15:47

Kezdetben volt az Ige, és az Ige Istennél volt, és Isten volt az Ige. Ő volt kezdetben Istennél. Minden általa lett, és nála nélkül semmi sem lett, ami lett. Benne élet volt, és az élet volt az emberek világossága. A világosság a sötétségben világít, de a sötétség azt föl nem fogta. Volt egy ember, akit Isten küldött, János volt a neve. Tanúskodni jött, hogy tanúskodjék a világosságról, s mindenki higgyen általa. Nem ő volt a világosság, csak tanúságot kellett tennie a világosságról. Az igazi világosság, aki minden embert megvilágosít, a világba jött. A világban volt, a világ őáltala lett, de a világ nem ismerte fel őt. A tulajdonába jött, övéi azonban nem fogadták be. Mindazoknak azonban, akik befogadták, hatalmat adott, hogy Isten gyermekei legyenek; azoknak, akik hisznek az ő nevében, akik nem a vérből, sem a test ösztönéből, sem a férfi akaratából, hanem Istenből születtek. Az Ige testté lett, és köztünk lakott, és mi láttuk az ő dicsőségét, mint az Atya egyszülöttének dicsőségét, aki telve volt kegyelemmel és igazsággal. János tanúságot tesz róla, és hirdeti: ,,Ő az, akiről ezt mondtam: Aki utánam jön, megelőz engem, mert előbb volt, mint én.' Mi mindnyájan az ő teljességéből merítettünk kegyelemből kegyelmet. Mert a törvényt Mózes által kaptuk, a kegyelem és az igazság pedig Jézus Krisztus által valósult meg. Istent soha senki nem látta: az egyszülött Fiú, aki az Atya kebelén van, ő nyilatkoztatta ki. Olvasmányok, ünnepek a liturgikus naptárban. | Felolvassa: Varga László |

tan nem volt aki minden mert ige isten benne krisztus kezdetben

ENCORE: Q&A with Leyla, Part 2: Reducing Coronary Plaque

Play Episode Listen Later Dec 30, 2025 28:38

What do you think of serrapeptase for reducing coronary plaque?We were told to get a TDAP vaccine or we wouldn't be able to see our new grandchild for 8 weeks!Do I have lupus?Which supplements tend to reduce negative effects of X-rays?

covid-19 health ms wellness medicine nutrition exercise fda reducing mercury protein breast cancer vitamins nutritionists vitamin d inflammation chronic pain breastfeeding holistic health immune system microbiome magnesium minerals integrative medicine lupus cholesterol tylenol parasites antibiotics lifespan osteoporosis food allergies alternative medicine processed food olive oil aluminum eczema omega3 leaky gut antioxidants cdn autoimmunity plaque registered dietitian nutritionist healthspan chiropractic care statins coronary ige vitamin k dvt vaccine safety atherosclerosis peanut allergies complementary medicine preservatives bladder cancer conventional medicine nutritional supplements coronary artery disease food additives prostate health gabapentin oxycodone homocysteine fullscript pertussis diphtheria low dose naltrexone finasteride gi tract tdap hygiene hypothesis detergents radiation protection bromelain saw palmetto spinal decompression calcium carbonate plant sterols vein health

ENCORE: Q&A with Leyla, Part 1: The Holiday Season in NYC

conversations science confidence testing pac scientific allergy food allergies ige thermo fisher scientific scientific affairs thermo fisher

Play Episode Listen Later Dec 30, 2025 31:59

The Holiday Season in NYCPeanut allergies cause and effectWhich calcium supplements can I take if I'm allergic to cow protein?Can my husband take saw palmetto in lieu of his prostate medications?What do you think of traction to help bulging discs?What is your take on green powder supplements?

covid-19 health new york city ms wellness medicine nutrition exercise fda holiday season mercury protein breast cancer vitamins nutritionists vitamin d inflammation chronic pain breastfeeding holistic health immune system microbiome magnesium minerals integrative medicine lupus cholesterol tylenol parasites antibiotics lifespan osteoporosis food allergies alternative medicine processed food olive oil aluminum eczema omega3 leaky gut antioxidants cdn autoimmunity registered dietitian nutritionist healthspan chiropractic care statins ige vitamin k dvt vaccine safety atherosclerosis peanut allergies complementary medicine preservatives bladder cancer conventional medicine nutritional supplements coronary artery disease food additives prostate health gabapentin oxycodone homocysteine fullscript pertussis diphtheria low dose naltrexone finasteride gi tract hygiene hypothesis detergents radiation protection bromelain saw palmetto spinal decompression calcium carbonate plant sterols vein health

EP38-从育儿焦虑到从容养育，看“研究型父母”如何“打怪升级”

IQ老友说

Play Episode Listen Later Dec 26, 2025 59:01

只是流个鼻涕，为什么会发展为哮喘？特应性皮炎和多动症竟息息相关？当孩子的咳嗽声响起，你是在深夜亮起屏幕，疯狂检索症状到天明，还是对照着育儿百科，逐条排查心中的不安？在信息触手可及的时代，育儿知识从未像今天这样透明又过载。新一代父母正在以“研究型”的姿态迎战养育挑战：他们刷论文、查指南、比口碑，力求在每一个选择上做到完美，用知识和信息为孩子构筑一道健康防线。然而，科学育儿的背后，焦虑也在悄然滋长，家长的“研究”模式，究竟是让孩子更健康，还是让亲子关系更紧张？本期播客邀请到上海儿童医学中心临床药学科主任李志玲以及意略明cbh消费品与大健康咨询事业部副总监Theresa Ye。她们将与我们一同探讨，当代父母如何在纷繁的育儿知识中找到定力，与医生高效沟通，共同成为从容的“育儿主理人”。-嘉宾-李志玲，上海儿童医学中心临床药学科主任TheresaYe，意略明cbh消费品与大健康咨询事业部副总监莉莉安，《IQ老友说》主播-精华highlight-01:57 为什么85-95后的父母呈现出独特的“研究型”特质？04:59 研究型家长就医都“有备而来”，对医生的综合水平提出了更高的要求06:24 研究型vs听话型家长，哪一类能更好地贯彻执行医嘱？08:53 恢复快≠好，医生用药需平衡疗效和不良反应这两大要素12:07 从湿疹、鼻炎、到哮喘是过敏的三部曲13:34 腺样体面容是如何形成的？14:05 孩子白天躁动不一定是多动症，可能是过敏性鼻炎引起的夜间缺氧所导致的15:25 什么是治疗过敏性鼻炎的“四位一体”？16:27 尘螨、宠物毛发、烟雾……生活中的常见过敏源有哪些？17:14 通过IgE测试和皮肤点刺测试过敏源，各有优劣18:43 过敏并不一定是因为免疫力低下，如何用药大有学问20:43 儿童过敏性鼻炎的诊疗旅程是怎样的？23:04 如何应对家中的头号过敏源——尘螨？25:40 特应性皮炎与多动症之间竟然有相关性28:39 孩子出现少言、多动、或是过矮、超重等情况，如何合适地进行干预？35:06 李主任的家庭小药箱里都装着什么“宝贝”？38:34 应对流感季的SOP：接种疫苗、家中自测、就医、选择科室……44:17 精神差、头痛、肌肉酸痛、高热不退，医生教你三招判断流感46:12 “研究型妈妈”选择奶粉可能要花半年之久49:26 孩子成长的各个阶段分别适合补充什么营养品？52:54 研究型家长切忌钻进完美主义的“牛角尖”56:35 最好的父母不是永不犯错，而是持续学习*本节目仅做信息交流之目的，嘉宾观点不代表任何公司立场- 制作团队 -沈旸、王心影、束菲滢- IQ老友说 -这是一档IQVIA艾昆纬的谈话类播客节目，聚焦医疗行业，网罗多元视角，激发观点碰撞，探寻新鲜洞见，让我们一起在轻松话聊的氛围中，老友说医疗，有趣又有料！- 关于IQVIA -IQVIA艾昆纬（纽交所代码：IQV）是全球领先的专注生命科学领域的高级分析、技术解决方案和临床研究服务供应商。IQVIA利用深入分析、前沿技术、大数据资源和广泛领域的专业知识，智能连接医疗生态的各个环节。IQVIA Connected Intelligence快速敏锐地为客户提供强大的数据洞察，帮助客户加速创新医疗的临床开发和商业化进程，以更好的医疗成果惠及患者。IQVIA拥有约88,000名员工，足迹遍布100多个国家/地区。IQVIA帮助生物科技、医疗器械、制药公司、医学研究者、政府机关、支付方以及其他医疗利益相关方，获得对疾病、人类行为和科技进步更深入的理解，共同朝着治愈各类疾病的方向迈进。- 互动方式 -关注IQVIA艾昆纬微信公众号，获取更多独家洞察！- 本节目由IQVIA出品，JustPod制作发行 -

iq sop ige

"Kezdetben volt az Ige" - 9h | Varga Nándor | 2025.12.25

KREK.hu Igehirdetések

Play Episode Listen Later Dec 25, 2025 60:14

Igerész: János 1,1-3 Lelkész: Varga Nándor Lejátszás közvetlen fájlból (hiba esetén): https://krek.hu/media/files/igehirdetesek/20251225_9h_VN_János1,1-3_Kezdetben_volt_az_Ige.mp3 Becsült hossz: 3614 mp Generálta: ScrapeCast by Fodor Benedek UUID: b487c1e2-e59a-439d-acb7-ec55e5da6fa7

volt iger varga ige kezdetben

karácsonyi idő Jézus születése| Jn 1,1-18 |

Napi evangélium

Play Episode Listen Later Dec 25, 2025 15:47

tan nem volt aki minden mert ige isten benne krisztus kezdetben

Ep. 121: “From Microbes to Metabolism” Featuring Dr. Jayne Danska

The Immunology Podcast

Play Episode Listen Later Dec 16, 2025 77:43

Guest: Dr. Jayne Danska is a Senior Scientist, Genetics and Genome Biology at the Hospital for Sick Children Research Institute. She is also Associate Chief of Research, Faculty Development and Diversity, and Professor at the University of Toronto. Her research focuses on the microbiome in type 1 diabetes. She discusses insights from longitudinal human studies and mouse models. (40:00) Featured Products and Resources: Register now for IMMUNOLOGY2026! Wallchart: T Cell Nomenclature: From Subsets to Modules The Immunology Round Up Vaccination for Anaphylaxis – A vaccine against IgE protected against anaphylaxis in a mouse model. (2:53) How RSV Can Lead to Asthma – Researchers identified maternal allergy and neonatal RSV infection as converging Fc receptor-dependent risk factors for asthma. (9:50) Antigen Presentation for MAIT Cell Immunity – Macrophages are key for MR1 antigen presentation and MAIT cell immunity. (20:30) HIV Remission after Stem Cell Transplantation – After an allogeneic stem cell transplant, a patient discontinued antiretroviral therapy and sustained HIV remission for over six years. (27:00) Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

university research professor toronto diversity hospitals hiv genetics metabolism rsv microbes senior scientist ige faculty development danska mait resources register associate chief featured products genome biology

Vaccine Science: Anaphylaxis Prevention, Adjuvant Controversies, Fentanyl Immunization, Exercise Fighting Cancer, and Sunlight's Hidden Benefits

Ask Doctor Dawn

Play Episode Listen Later Dec 6, 2025 50:01

Broadcast from KSQD, Santa Cruz on 12-04-2025: Dr. Dawn opens with an experimental vaccine that prevents severe allergic reactions by targeting IgE antibodies. The vaccine could eventually replace current monoclonal antibody treatments like omalizumab that require injections every two weeks. She explains how adjuvants work in vaccines as additives that irritate the immune system enough to notice the vaccine target. Aluminum hydroxide is s common adjuvant. Modern vaccines use small pathogen fragments rather than whole organisms, requiring adjuvants to trigger adequate immune response. Dr. Dawn expresses concern about the US Advisory Committee on Immunization Practices reviewing aluminum adjuvants this week. A Danish study of over one million children finding no connection between aluminum with autism and ADHA contradicts RFK,Jr's public claims.She worries that removing aluminum could devastate vaccine effectiveness and children's health, noting that whenever vaccination rates drop, diseases like measles return to native circulation. She recounts pertussis vaccine history—when Japan stopped vaccination due to rare adverse reactions (approximately one death per million doses), they lost about 5,000 children to whooping cough in the first year. The newer acellular vaccine using pathogen fragments plus adjuvants is safer but only lasts 4-5 years versus lifetime immunity from the older whole-cell version, necessitating "cocooning" strategies where everyone contacting newborns must be recently vaccinated. Dr. Dawn describes a vaccine to prevent fentanyl from reaching the brain now starting clinical trials in the Netherlands. It pairs a fentanyl-like molecule with a carrier protein large enough to trigger antibody production. Once primed, the immune system attacks any fentanyl entering the blood, preventing highs and overdoses—potentially helping people in addiction recovery and those accidentally exposed through contaminated drugs. She reports the first documented death from alpha-gal syndrome. Alpha-gal is a meat allergy triggered by Lone Star tick bites; the tick essentially vaccinates humans against the alpha-galactosidase protein found on beef and pork. Cases have increased since 2010 as climate change expands the tick's range northward, yet a 2023 survey found 42% of doctors had never heard of the condition. Dr. Dawn highlights research from Edith Cowan University showing that blood drawn after exercise suppresses cancer cell growth when added to tumor cultures. In breast cancer survivors, plasma from high-intensity interval training or weight lifting caused cancer cells to stop growing or die; blood drawn before exercise had no effect. The key mechanism involves myokines, particularly IL-6, released by contracting muscles. A Stanford study found colon cancer survivors who exercised were 37% less likely to experience recurrence. A caller asks about pig-to-human heart transplants and mask recommendations. Dr. Dawn clarifies that newer xenotransplant pigs have more genes edited to reduce rejection compared to the 2022 case. For masking, she recommends context-dependent use—especially in public restrooms where toilet flushing aerosolizes COVID-containing particles, transportation hubs, and hospitals, noting that COVID vaccination prevents death but not infection or long COVID. She advises the same caller about spacing vaccines because adjuvant loads stack. Most vaccines can be combined safely, but she recommends against pairing COVID and Shingrix vaccines due to their heavy adjuvant content—wait at least ten days between them. She suggests inducing a sweat the night of vaccination through hot baths, saunas, or exercise to reduce adjuvant-related discomfort without diminishing antibody response. Dr. Dawn discusses seasonal affective disorder. She recommends 5,000 units of vitamin D3 and morning light exposure. She suggests that sun avoidance advice may have gone too far. A UK study of 3.36 million people found 12-15% lower mortality with greater UV exposure even accounting for skin cancer risk. A Swedish study following 30,000 women for 20 years found sun-seekers had half the mortality risk. Benefits may involve nitric oxide production lowering blood pressure, with each 1,000 km from the equator correlating with 5 mmHg higher blood pressure. Lack of bright outdoor light also contributes to childhood myopia, with rates exceeding 80% in some Asian cities. Dr. Dawn concludes with Danish microbiologists at Copenhagen's Alchemist restaurant reviving an old Bulgarian practice of fermenting milk with live red wood ants. The resulting yogurt, cheese, and ice cream contain far more beneficial microbes than commercial products, with a complex lemony acidity. Only live ants work, and wild ants may carry parasites dangerous to humans.

Test with Confidence: A Conversation with Gary Falcetano, PA-C of ThermoFisher Scientific on AGS Testing

In the Tall Grass

Play Episode Listen Later Dec 4, 2025 32:33

In this conversation, we pull back the curtain on alpha-gal syndrome diagnostic testing at Thermo Fisher Scientific with Gary Falcetano, PA-C. Gary shares insights into how the alpha-gal syndrome test works and answers some of our most frequently asked questions. How do you talk to your provider about being tested? Is the test covered by insurance? What provider can order the test? He also dives into how Allergy Insider, Thermo Fisher's patient resource, is bringing alpha-gal into the conversation. Tune in now to learn more! Gary Falcetano, PA-C, serves as Senior Manager Global Medical and Scientific Affairs for allergy at Thermo Fisher Scientific. Gary has been a Board Certified Physician Assistant for over 28 years, and is the host of Allergy Insider's ImmunoCAST podcast.Visit Allergy Insider to learn more about their patient resources and be sure to follow on social media: @allergyinsider

Food In, Fire Out

Dr. Baliga's Internal Medicine Podcasts

Play Episode Listen Later Nov 28, 2025 4:48

nejm ige

ENCORE: Q&A with Leyla, Part 2: Menstrual Cramps

Play Episode Listen Later Nov 27, 2025 35:48

My granddaughter suffers from menstrual cramps. Do you have any suggestions?Do you recommend nicotinamide daily to prevent recurrence of basal cell cancers?What works best to lower fibrinogen?I've been on Ozempic for a year and have diarrhea every morning!Is bypass surgery still being done?Would you recommend Bergamot for fatty liver?

health thanksgiving stress ms depression wellness medicine entrepreneurship startups nutrition exercise adhd diet alcohol weight loss fda newsletter shark tank supplements radio show obesity vitamins listener questions gut health stroke venture capital ozempic nutritionists vitamin d pms dopamine holistic health heart attacks birth control paleo microbiome endometriosis telehealth plastic surgery probiotics magnesium minerals integrative medicine cholesterol gluten free nurse practitioners pfas lifespan telemedicine blood sugar estrogen hair loss patient care antidepressants wegovy hypertension calcium food allergies alternative medicine diarrhea insulin resistance gut microbiome skin cancer cdn sleep deprivation physician assistants metabolic health environmental health health podcast cgm salmonella registered dietitian nutritionist healthspan food poisoning health professionals ecoli statins blood clots forever chemicals ige low carb diets curcumin medical advice fatty liver health technology polycystic ovarian syndrome complementary medicine continuous glucose monitors triglycerides b vitamins conventional medicine nutritional supplements medical innovation insulin sensitivity mast cell activation syndrome niacin staph anti inflammatory diet coronary artery disease cardiovascular risk gastric bypass bergamot health supplements stents omega 3 fatty acids minoxidil psychiatric medication squamous cell carcinoma milk thistle manjaro holistic doctors campylobacter menstrual cramps nicotinamide carnitine medical studies basal cell carcinoma nattokinase cardiovascular prevention angioplasty fibrinogen actinic keratosis

ENCORE: Q&A with Leyla, Part 1: Thanksgiving and Overindulgence

Infectious Disease Puscast

Play Episode Listen Later Nov 27, 2025 33:22

Thanksgiving and overindulgenceA food poisoning incidentObservations on health at ThanksgivingWhat do you think of online sites offering prescriptions for hair loss via a questionnaire?

health thanksgiving stress ms depression wellness medicine entrepreneurship startups nutrition exercise adhd diet alcohol weight loss fda newsletter shark tank supplements radio show obesity vitamins listener questions gut health stroke venture capital ozempic nutritionists vitamin d pms dopamine holistic health heart attacks birth control paleo microbiome endometriosis telehealth plastic surgery probiotics magnesium minerals integrative medicine cholesterol gluten free nurse practitioners pfas lifespan telemedicine blood sugar estrogen hair loss patient care antidepressants wegovy hypertension calcium food allergies alternative medicine diarrhea insulin resistance gut microbiome skin cancer cdn sleep deprivation physician assistants metabolic health environmental health health podcast cgm salmonella registered dietitian nutritionist healthspan food poisoning health professionals ecoli statins blood clots forever chemicals ige low carb diets curcumin medical advice fatty liver health technology polycystic ovarian syndrome complementary medicine continuous glucose monitors triglycerides b vitamins conventional medicine nutritional supplements medical innovation insulin sensitivity mast cell activation syndrome niacin staph anti inflammatory diet coronary artery disease cardiovascular risk gastric bypass bergamot health supplements stents omega 3 fatty acids overindulgence minoxidil psychiatric medication squamous cell carcinoma milk thistle manjaro holistic doctors campylobacter menstrual cramps nicotinamide carnitine medical studies basal cell carcinoma nattokinase cardiovascular prevention angioplasty fibrinogen actinic keratosis

Infectious Disease Puscast #94

Play Episode Listen Later Nov 25, 2025 45:46

On episode #94 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/11/25 – 11/19/25. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus (Science Translational Medicine) Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice (CID) Antimicrobial drug-resistant Neisseria gonorrhoeae (GC) infections in men using doxycycline postexposure prophylaxis. A substudy of the ANRS 174 DOXYVAC trial (CID) HIV Pre-exposure Prophylaxis Does Not Increase Gonorrhea and Chlamydia Incidence in Young Black and Hispanic Men who Have Sex With Men: An Observational Cohort Study (OFID) Bacterial Global and regional knowledge of antibiotic use and resistance among the general public: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection) Infant Botulism Outbreak Linked to Infant Formula, November 2025 (CDC: Botulism) Outbreak Investigation of Infant Botulism: Infant Formula (November 2025) (FDA) Vitamin D deficiency at hospital admission with community-acquired pneumonia is associated with increased risk of mortality: A Prospective Cohort Study (OFID) Bat-Associated Hemotropic Mycoplasmas in Immunosuppressed Children, Spain, 2024 (Emerging Infectious Diseases) A Multicomponent Intervention to Improve Maternal Infection Outcomes (NEJM) Fungal The Last of US Season 2 (YouTube) Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024) (JID) British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update (LANCET: Infectious Diseases) In Vivo Evolution of Candida auris Multidrug Resistance in a Patient Receiving Antifungal Treatment (JID) Parasitic Implications of a fatal anaphylactic reaction occurring 4 hours after eating beef in a young man with IgE antibodies to galactose-α-1,3-galactose (JACI: Journal of Allergy and Clinical Immunology In practice) WHO recommends R21/Matrix-M vaccine for malaria prevention in updated advice on immunization (WHO) Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi (LANCET: Global Health) A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication? (PLoS Neglected Tropical Diseases) Miscellaneous IL12RB1 deficiency appearing in North America: expanding the clinical phenotypes (CID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

spain north america kenya ghana infectious diseases allergy gc rts us season young black ige infant formula neisseria medical mycology

#137 - Diagnosing Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

university worse foods patterns guidelines food allergies eczema make things help your child ige

Play Episode Listen Later Nov 20, 2025 34:10

Persistent congestion, pressure, or a reduced sense of smell often gets mistaken for allergies or a stubborn cold when it may be something more, like chronic rhinosinusitis with nasal polyps (CRSwNP). Getting the right diagnosis is the first step toward real relief. Dr. Tonya Farmer, a board-certified ENT, joins Kortney and Dr. G to explain how chronic rhinosinusitis with nasal polyps (CRSwNP) is diagnosed. She walks us through the full evaluation: what symptoms matter, what a nasal endoscopy actually shows, when a CT scan is needed, and how type 2 inflammation fits into the picture. What we cover about diagnosing CRSwNP: Key symptoms: Persistent congestion, drainage, facial pressure, and especially loss of smell are major red flags for CRSwNP. Why duration matters: Chronic means 12 weeks or longer. If symptoms keep coming back or never truly improve, it's time to look deeper. The physical exam: ENTs use nasal endoscopy to see swelling, mucus, or polyps that aren't visible from the outside. When CT scans are needed: Imaging helps confirm sinus inflammation and shows the extent of polyp growth. Additional testing: Allergy testing, IgE levels, eosinophils, and other immune markers help identify type 2 inflammation and guide next steps. When to see a specialist: If antibiotics, steroids, or over-the-counter treatments aren't helping, ask for a referral to an allergist or ENT. Early diagnosis can prevent worsening symptoms and reduce the need for surgery. Set the foundations: Ep. 133: What is Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)? ___ Made in partnership with The Allergy & Asthma Network. Thanks to Sanofi for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

ent chronic persistent allergy imaging diagnosing nasal sanofi ige ents kortney polyps rhinosinusitis crswnp

Ep. 119: “Systemic Lupus Erythematosus” Featuring Dr. George Robinson

The Immunology Podcast

Play Episode Listen Later Nov 18, 2025 59:15

Guest: Dr. George Robinson is a Principal Research Fellow at University College London, where his lab focuses on juvenile-onset systemic lupus erythematosus. He discusses current approaches to diagnosis and treatment, as well as the role of sex differences in autoimmunity. (31:20) Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Download a free wallchart on regulatory T cells. The Immunology Round Up Long-Term Allergies: Allergy-associated IgE plasma cells exhibit limited accrual in the bone marrow, and instead reside in other tissues for extended periods. (3:40) Oral Immunotherapy for Peanut Allergy: Peanut oral immunotherapy reshapes T cell responses, suppressing allergy-associated type 2 helper T cells and boosting cytotoxic type 1 helper T cells, offering clues to long-term tolerance. (9:00) Neuroprotective Microglia in Alzheimer’s Disease: The protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with amyloid plaques. (18:09) Autoimmunity in ALS: Researchers showed that ALS is associated with recognition of the C9orf72 antigen and mapped the specific epitopes that are recognized. (23:20) Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

als alzheimer's disease university college london pu autoimmunity ige systemic lupus erythematosus principal research fellow featured products george robinson c9orf72

Will Removing Foods Help Your Child's Eczema—or Make Things Worse?

Eczema Breakthroughs

Play Episode Listen Later Nov 5, 2025 22:01

Can specific foods trigger eczema and does avoiding them make eczema better? Many parents give it a try—but experts say it's not the right approach. So what's going on? We talk to Dr. Matthew Ridd, a leading eczema and food allergy researcher from the University of Bristol, to find out what the science actually says about diet and eczema. ReferencesTIGER (Trial of food allergy (IgE) tests for Eczema Relief)Food Allergy Test‐Guided Dietary Advice for Children With Atopic DermatitisGuidelines of care for the management of atopic dermatitisAtopic dermatitis (eczema) guidelines Guidelines for Early Food Introduction and Patterns of Food Allergy

200 | Should You Do Allergy Testing for Eczema? What Doctors Don't Tell You About Scratch Tests, Immunotherapy and True Allergies

Eczema Kids - Natural Eczema Solutions, Eczema-friendly diet, baby eczema, toddler eczema, best products for eczema, skin sen

Play Episode Listen Later Oct 28, 2025 13:53

Want to heal your child's eczema without steroids and save $200 this week? Click here to get started → EczemaKids.com Use code EPISODE200 to get $200 off the Eczema Elimination Method.... the COMPLETE eczema-reversal system that actually works. This offer is good for one week only and ends Tuesday, November 4th, 2025. If your child's ever had an allergy test hoping for answers, only to walk out more confused or flaring, this episode is for you. As we celebrate 200 episodes (and my birthday week!), I'm breaking down what allergy tests actually measure, why kids with eczema often react badly, and how to tell the difference between true, serious IgE allergies and immune overload. We'll talk about why scratch tests and immunotherapy often do more harm than good for eczema families, what to do if your child already flared after testing, and how to start healing their skin and gut from the inside out.

doctors testing lifetime tests scratch allergies allergy eczema immunotherapy voxer ige

Episode 108: Allergist Insights: Choosing Biologics for Chronic Urticaria and Beyond - A 2025 SF Derm Session | The Future of Dermatology Podcast

The Future of Dermatology

Play Episode Listen Later Oct 14, 2025 9:07

Summary In this truncated replay, Dr. Shyam Joshi explores the intersection between allergy and dermatology—focusing on how chronic spontaneous urticaria (CSU), atopic dermatitis, and food allergies often overlap. Learn how emerging biologics like omalizumab and dupilumab are reshaping treatment decisions, why comorbidities matter, and how collaboration between allergists and dermatologists creates better outcomes for patients with complex allergic and dermatologic conditions. This episode dives into real-world case studies, FDA updates on antihistamines, and the multidisciplinary approach to managing eczema and CSU in pediatric and adult populations. Takeaways - FDA Advisory on Antihistamines: Long-term use of cetirizine or levocetirizine can lead to rebound pruritus upon discontinuation—but gradual tapering minimizes symptoms. - Biologic Selection Depends on Comorbidities: - Omalizumab is effective for IgE-mediated food allergies and chronic urticaria. - Dupilumab is preferred for patients with eosinophilic esophagitis (EoE) or moderate-to-severe atopic dermatitis. - CSU Is Systemic: Symptoms may extend beyond hives—impacting joints, sleep, and energy levels. - Comorbid Conditions Are Common: Up to 20 % of CSU patients have asthma, allergic rhinitis, or food allergies; identifying these helps guide treatment and patient education. - Unified Messaging Builds Trust: Consistent communication from both dermatologists and allergists reduces unnecessary testing and supports adherence to treatment plans. Chapters 00:00 - Introduction: Bridging Allergy and Dermatology 00:45 - Case Study: An 18-Year-Old with Chronic Urticaria 02:00 - FDA Warning: Antihistamine Withdrawal Itch 03:45 - Selecting the Right Biologic: Food Allergy Considerations 04:45 - Eosinophilic Esophagitis and CSU 05:35 - The Systemic Nature of CSU 06:40 - Comorbidities in CSU and Atopic Patients 07:30 - Multidisciplinary Collaboration in Practice 08:00 - Closing Thoughts & Educational Disclaimer

fda chronic selecting closing thoughts der m csu dermatology year old biologics comorbidities ige eoe allergist urticaria eosinophilic esophagitis

#131 - What Is a BTK Inhibitor?

Play Episode Listen Later Oct 9, 2025 22:44

For decades, allergists have focused on blocking what happens outside the mast cell: histamine, IgE, and interleukins. But now, there's a new way to stop allergic inflammation before it even starts: by targeting what happens inside the cell with BTK Inhibitors. Dr. Payel Gupta and Kortney are joined by Dr. Matthew Giannetti to unpack what BTK actually does and why inhibiting it represents an exciting breakthrough in allergy and immunology. Together, they explore how BTK inhibitors work, why this inside-the-cell approach is different from anything before, and what it could mean for people living with chronic spontaneous urticaria (CSU). What the episode covers about BTK inhibitors: BTK explained: Bruton's tyrosine kinase is a pivotal “last step” before mast-cell degranulation. How BTK inhibitors work: Blocking BTK can stop histamine release downstream of many outside triggers. The science: Why BTK binding is irreversible for each molecule and how the body “re-makes” BTK over time. Safety in brief: A look at petechiae (small pinpoint spots), what to monitor, and how shared decision-making guides treatment choices. The future of BTK inhibitors: Exploring their potential role in other allergic conditions. ____ Made in partnership with The Allergy & Asthma Network. Thanks to Novartis for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

safety exploring allergy csu novartis btk ige inhibitor bruton kortney

#129 - Omalizumab for Multiple Food Allergies – The OUtMATCH Trial

explore medicine trial treatments fda gupta allergy food allergies new england journal infographics genentech ige kortney

Play Episode Listen Later Sep 26, 2025 39:37

Multiple food allergies are a daily stressor for millions of families. From avoiding social events to fearing accidental exposures, it can feel like living in a constant state of alert. Until recently, there were no FDA-approved treatments that targeted more than one allergen at a time. In this episode, we break down the study: “Omalizumab for the Treatment of Multiple Food Allergies,” published in 2024 in the New England Journal of Medicine. Known as the OUtMATCH trial, it's the first large-scale study to show that omalizumab (Xolair), a biologic already used for asthma and hives, may help people with multiple food allergies by raising the threshold for reactions. We explain how omalizumab works by blocking IgE, the antibody that triggers allergic reactions, and how the study measured changes in reaction thresholds (the amount of an allergen a person can ingest before reacting). We also explore the trial design, results, safety profile, and what all of this means for the day-to-day management of food allergies. What we cover in our episode about OUtMATCH trial How omalizumab works to prevent allergic reactions: Learn how blocking IgE increases the amount of allergen needed to trigger symptoms, offering protection from small, accidental exposures. Who qualified for the OUtMATCH trial and why: Find out which patients were included and how eligibility impacted outcomes. What success looked like in this study: Understand how researchers defined protection across multiple allergens. Why not everyone responded the same to omalizumab: Explore the variability in results and what it means for clinical care. What else the study found beyond food challenges: Hear about safety findings, quality of life data, and the open-label extension.

Penicillin Allergy?

PEM Currents: The Pediatric Emergency Medicine Podcast

Play Episode Listen Later Sep 24, 2025 10:00

Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.

#128 - Is Chronic Spontaneous Urticaria an Autoimmune Disease?

chronic allergy spontaneous autoimmune autoimmune disease csu novartis igg ige kortney urticaria

Play Episode Listen Later Sep 18, 2025 26:45

When people get hives or swelling, they often think it's caused by an allergy. But in the case of chronic spontaneous urticaria (CSU), the culprit is often your own immune system. CSU isn't your typical allergic reaction, instead, it's frequently an autoimmune condition, where the immune system misfires and activates mast cells without any external trigger. In this episode, Dr. Payel Gupta and Kortney unpack what it means for CSU to be autoimmune and autoallergic. They explain how IgE and IgG antibodies can trigger histamine release, leading to hives and swelling. You'll also learn why allergy testing isn't useful for diagnosing CSU, and how tests like IgG food sensitivity panels can do more harm than good by leading to unnecessary food avoidance and confusion. What we cover in our episode about autoimmune CSU and chronic hives: Is CSU an allergy? Why CSU is often mistaken for an allergic reaction—and why standard allergy tests rarely provide helpful answers. How the immune system works in CSU: What mast cells are, how they release histamine, and their central role in chronic spontaneous urticaria. Understanding autoimmune CSU: Learn how the immune system can trigger hives from within, including the roles of IgE and IgG antibodies. Autoimmune hives explained: We explore how CSU can be autoimmune, why the immune system may attack itself, and what Type I and Type IIb autoimmune CSU really mean. ____ Made in partnership with The Allergy & Asthma Network. Thanks to Novartis for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Urticaria and angioedema in children: Key clinical insights

Healthed Australia

Play Episode Listen Later Sep 11, 2025 34:35

Definitions and distinguishing features of urticaria and angioedema Common causes of acute urticaria in children and why infection is the leading driver When to suspect IgE-mediated allergy and how to recognise signs of anaphylaxis Practical dosing guidance for non-sedating antihistamines and the role of steroids Red flags that warrant referral and the place of biologics in chronic urticaria Host: Dr Rebecca Overton, GP and Medical Educator Expert: Dr Gabby Mahoney, Paediatric Allergist and Immunologist Total time: 35 mins Register for our fortnightly FREE WEBCASTS Every second Tuesday | 7:00pm-9:00pm AEST Click here to register for the next oneSee omnystudio.com/listener for privacy information.

children practical register gp definitions ige urticaria clinical insights angioedema onesee

From Clinic to Lab: The Allergy Diagnostic Journey

Play Episode Listen Later Aug 21, 2025 32:53

Did you know that IgE, the antibody responsible for allergic reactions, is 30,000 times less abundant than other immunoglobulins in the body? This staggering fact underscores the importance of highly sensitive allergy diagnostics. In this episode, we pull back the curtain on what happens to allergy diagnostic blood samples after they leave your clinic. Clinical laboratory expert Jessica Murphy, MLS (ASCP), guides us through the intricate process of specific IgE testing, from sample processing to result interpretation. Learn about the advanced technology behind ImmunoCAP™ allergy diagnostics, the role of Phadia™ Laboratory Systems in ensuring accurate results, and the meticulous quality control measures employed by Thermo Fisher Scientific. Discover how regional respiratory profiles are curated, the significance of binding capacity in IgE detection, and the collaborative effort between clinicians and lab experts in reaching accurate diagnoses. Gain insights into interpreting allergy diagnostic results and their impact on patient management, illustrated through a real-world case study of a young patient with respiratory symptoms. Resources and references here: https://www.thermofisher.com/phadia/us/en/resources/immunocast/allergy-diagnostics-blood-draw-process.html

discover clinical clinic allergy diagnostic ige thermo fisher scientific jessica murphy

Rural Allergy Risks: A Clinical Examination of Horse Allergy and Beyond