Podcasts about changeux

Stanislas DehaeneChaire Psychologie cognitive expérimentaleAnnée 2025-2026Collège de FranceColloque : Seeing the Mind, Educating the BrainTheme: Perception and ConsciousnessThe Global Neuronal Workspace from the Molecular to the Cognitive Level: Consequences for Pathology and PharmacologyColloque - Jean-Pierre Changeux : The Global Neuronal Workspace from the Molecular to the Cognitive Level: Consequences for Pathology and PharmacologyJean-Pierre ChangeuxRésuméThe global neuronal workspace (GNW) theory originates from decades-long productive dialogs between Dehaene & Changeux which aimed, in the late 80's, at the elaboration of formal neuronal networks of cognitive functions. They initially included birdsong learning by selection, the Wisconsin card sorting task, infants numerosity detection...All these models were grounded on a molecular level which included allosteric neurotransmitter receptors. In 1998, the "global neuronal workspace" was integrated into a formal organism in order to pass the effort-full, "conscious", Stroop task. It was postulated to consist of a brain-scale—multimodal & horizontal—network of widely distributed neurons with long axon neurons, distinct from modality-specific localized non-conscious processors, including neurons which included the prefontal, parieto-temporal, cingulate… areas. The access of an outside representation to the conscious workspace would manifest itself by an "ignition" of the workspace network. At this stage, an important number of imaging and electrophysiological data appear consistent with the GNW theory. In this contribution, emphasis shall be given to the bottomup contribution of the molecular level and its consequences for the understanding of neuropsychiatric diseases and rational drug design, in the larger context of a novel precision pharmacology.

Je dialogue avec Jean-Pierre Changeux, éminent neuroscientifique français à l'origine de nombreuses découvertes de tout premier plan.Acheter le livre de Jean-Pierre Changeux : https://www.albin-michel.fr/le-beau-et-la-splendeur-du-vrai-9782226476784Mon site : https://www.fabricemidal.comMots clé : Ce livre d'entretiens retrace l'aventure intellectuelle d'une vie, celle d'un exceptionnel savant, Jean-Pierre Changeux,　avec ses réussites et ses difficultés. Pionnier du développement d'une nouvelle discipline, la neuroscience, dont la visée est de comprendre la complexité de notre cerveau par l'intégration concomitante de ses multiples niveaux d'organisation, depuis ses fondements moléculaires jusqu'à la vie mentale et la conscience, il a su dès 1983, avec son retentissant Homme neuronal, intéresser un large public au fonctionnement du cerveau de l'homme.Sa réflexion s'étend aussi aux Sciences de l'homme et de la société quand il explique combien est déterminante la contribution de notre équipement cérébral à la genèse des règles éthiques et à la compréhension de l'art et de sa création.Face à l'« apocalypse » qui menace notre planète, les chercheurs ont une part de responsabilité, c'est pourquoi Jean-Pierre Changeux appelle de ses vœux la mise en place d'une véritable éducation scientifique et éthique, applicable au monde politique comme à la société tout entière. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

durée : 00:53:24 - L'Heure bleue - Jean-Pierre Changeux, neurobiologiste, "Le beau et la splendeur du vrai" (Albin Michel)

durée : 02:29:28 - Le 7/9.30 - Mathieu Palain, écrivain, auteur de Nos pères, nos frères, nos amis (Les Arènes), Aurore Bergé, présidente du groupe Renaissance à l'Assemblée nationale, et Jean-Pierre Changeux, neurobiologiste, auteur de Le beau et la splendeur du vrai (Albin Michel), sont les invités de la matinale.

On se retrouve cette semaine pour un sujet très très très complexe. Ce sujet m'a vraiment donné du fil à retordre, autant qu'il en donne à tous les chercheurs en neurosciences qui travaillent sur le sujet. Je parle de, roulement de tambour bien que ce soit marqué dans le nom de l'épisode, la conscience !La question : existe-t-il une origine cérébrale de la conscience est une des plus grandes questions du 21ème siècle pour la recherche scientifique. Et avant même que les scientifiques ne s'en mêlent, la conscience, sa définition et son origine a été une grande préoccupation des philosophes.Dans cet épisode, j'essayerais donc de vous partager où nous en sommes aujourd'hui dans la recherche portant sur la conscience. Comment définit-on la conscience ? D'où émerge la conscience ? Peut-on localiser la conscience dans le cerveau ? Quels éléments sont nécessaires pour faire émerger la conscience d'un individu ? Si vous souhaitez avoir un éclairage neuro sur un sujet en particulier de la vie quotidienne, de notre fonctionnement, écrivez-moi à neurosapiens.podcast@gmail.com Production, animation, réalisation et illustration : Anaïs RouxLe podcast en version blog : www.neurosapiens.frA bientôt pour un nouvel épisode !SOURCES :S. Dehaene, Le Code de la conscience, Odile Jacob, 2014. L. Naccache, Le Nouvel Inconscient, Odile Jacob, 2006.S. Dehaene et al., What is consciousness, and could machines have it ?, Science, 27 octobre 2017.M. Babo-Rebelo et al., Neural responses to heartbeats in spontaneous thoughts, Journal of Neuroscience, 27/07/2016.S. Achard et al., Hubs of brain functional networks are radically reorganized in comatose patients, PNAS, en ligne le 26 novembre.S. Silva et al., Disruption of posteromedial large-scale neural communication predicts recovery from coma, Neurology, en ligne le 11/10/2015.O. Gosseries et S. Laureys, La conscience, comment la déceler ?, Pour la Science n°422, décembre 2012.S. Dehaene, J.-P. Changeux, Experimental and theoretical approaches to conscious processing, in Neuron, vol. 70, p. 200, 2011.S. Kouider et al., How rich is consciousness ? The partial awareness hypothesis, in Trends in Cognitive Sciences, vol. 14, pp. 301-307, 2010.Z. Huang et al., Temporal circuit of macroscale dynamic brain activity supports human consciousness, Science Advances, vol. 6, n° 11, eaaz0087, 11 mars 2020.K. Stiefel et al., The claustrum's proposed role in consciousness is supported by the effect and target localization of Salvia divinorum, in Front. Integr. Neurosci., vol. 8, 2014. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out. Become a member at https://plus.acast.com/s/neurosapiens.

durée : 01:28:34 - Jean-Pierre Changeux, neurobiologiste - par : Priscille Lafitte - Jean-Pierre Changeux nous invite à le suivre dans le labyrinthe des recherches en neurobiologie, aborder les questions qui se posent encore sur les capacités musicales de notre cerveau. Ami de Pierre Boulez, amoureux de l'orgue, Jean-Pierre Changeux revient sur les fondamentaux de la création. - réalisé par : Marie Grout

"I think in terms of consciousness, it seems to me that these Feelings of Knowing are perhaps the conscious tip of the iceberg for this huge amount of unconscious processing that's going on of all this information in our environment, where maybe I couldn't tell you why I know there's danger, but I know." - Alea Skwara, PhD Candidate in the Perception, Cognition, and Cognitive Neuroscience (PCCN) area of the Psychology Department at UC Davis   Global Workspace Theory: Exploring Evidence for Widespread Integration & Broadcasting of Conscious Signals - Part Two Episode 17 of the Podcast On Consciousness with Bernard Baars explores the links between cutting edge brain evidence and how that supports or updates our understanding of consciousness and the Global Workspace Theory (GWT).   Talking Points 0:00 – Intro 5:24 – History of Global Workspace Theory 8:23 – Discussion Paper #1: Baars et al. (2013) Global Workspace Dynamics  9:32 - What is meant by “Widespread Integration?” 17:22 – The Neuroscience of Widespread Integration 25:26 – Corticothalamic Loops in Relation to GWT 30:10 – Localist vs Local-Global Theories 35:46 – “The Question of Introspection” 43:01 – How is Consciousness Assessed? 49:58 – Feelings of Knowing (FOKs) 54:33 – Discussion Paper #2: Gaillard et al. (2009) Converging Intracranial Markers...  1:04:20 – Discussion Paper #3: Herman et al. (2019) A Switch & Wave of Neuronal Activity 1:14:55 – Brain Oscillations: Gamma and Beta Bands 1:20:56 – Paper #4: Deco et al. 2019 Revisiting the Global Workspace 1:26:29 – Functional Rich Clubs 1:41:50 – The Future Quest for Consciousness   Summary Episode 17 is the second in a three-part series on GWT Origins & Evidence, featuring our student interviewers, Alea Skwara and Ilian Daskalov. Together with Bernard Baars, they examine the recent neuroscientific study of consciousness. After some quick introductions, Alea briefly summarizes their discussion in Part I on the history of Global Workspace, how the theory evolved, as well as some of the core hypotheses it generates. Now we dive into the brain evidence.  Global Workspace Theory (or GWT) was first formulated in the ‘80s as a psychological theory of how consciousness might operate. In Part I, we talked about the spotlight metaphor. One of the key predictions of GWT is “widespread integration and broadcasting.” This seems to be one of the predictions that can be most directly tested by brain activity, our topic today.   Cortical Binding and Propagation The trio delves into the first of 4 papers, namely Baars' 2013 paper called “Global Workspace Dynamics.” This paper comes as the result of four decades of cumulative work, which pulls together the evidence as of 2013. One of its key points connecting GWT to neuroscientific evidence is that GWT does not require (or suggest) an “anatomical hub” of coordinated activity, but, instead, a momentary, dynamic “functional hub.”  Bernie, Alea and Ilian explore the question: What is the difference between an anatomical hub and a functional hub, and what does it mean to say that a functional hub is dynamic? Bernie explains how the conscious brain is characterized by ‘widespread integration and broadcasting.' The cortex is like a large city with specialized neighborhoods, streets and alleys. There is an ever changing flow of traffic between them. He then suggests that the thalamus is more than a relay station of the brain, and that the sensory thalamus is an entryway to the giant cortico-thalamic (CT) system, which integrates and broadcasts conscious information. Next, Ilian asks how we can experimentally test conscious processes. This moves the conversation to Feelings of Knowing (FOKs), which is one fundamental type of conscious experience. Bernie makes the point that Feelings of Knowing are an integral part of the conscious stream.   Evidence for GWT: Conscious Access, Gamma Activity, and Functional Rich Clubs The next paper is by Gaillard et al. (2009). It is an outstanding example of reading work from France by Dehaene and Changeux in Paris. The title is “Converging Intracranial Markers of Conscious Access, ” and it represents probably the most precise and accurate evidence so far for cortical integration and broadcasting. The experiment compared conscious and unconscious processing of briefly flashed words. Our trio asks the question: How does the observed effect of longer lasting and more widespread brain activity during conscious perception of a word offer support for GWT? Alea explains how this evidence confirms that conscious perceptual activity is propagated widely throughout the cortex. The third target paper is from a famous Yale epilepsy research group, led by Hal Blumenfeld, and the first author is Wendy X. Herman. It is titled, “A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception” (2019), and reinforces our message. Alea summarizes this third paper in the discussion, which looks at conscious perception in humans by using direct electrical recordings from the cerebral cortex during a visual perception task. Herman et al. discovered that stimuli that were consciously perceived elicited large-scale network switching, followed by waves of gamma activity. These findings support the hypothesis that such large waves are an indication of coordinated local-global activity.  Our trio asks: What might be the special significance of the gamma and beta bands to consciousness? An important recent paper by Deco et al. (2019) links this research to the major discovery of the cortical connectome, the street map of the cortex. It is called “Revisiting the Global Workspace.”  This fourth and final paper, with coauthors Deco, Vidaurre, and Kringelbach, examined neuroimages from over 1000 participants and created a full brain hierarchy in what the researchers defined as ‘functional rich clubs.' These ‘clubs' correlate activity between brain regions and strengthen the idea that Global Workspace is dynamic, but not necessarily in a grossly visible way. Our trio explores: What does Deco's idea of an “invariant global workspace” mean?   The Future Quest for Consciousness  As our trio wraps up, Ilian wants to know about the future of “the quest for consciousness.” Bernie and Alea agree that combining brain recordings with phenomenological interviews during meditation is very exciting.   Links to Papers Discussed in the Episode Paper 1: “Global Workspace Dynamics: Cortical ‘Binding and Propagation' Enables Conscious Contents Paper 2: Converging Intracranial Markers of Conscious Access Paper 3: A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception Paper 4: Revisiting the Global Workspace: Orchestration of the Functional Hierarchical Organisation of the Human Brain   Bios Alea Skwara is a PhD candidate at the University of California, Davis where she studies cognitive neuroscience. Her primary research focuses on compassion and responses to suffering. The main question that Alea is currently trying to answer is whether meditational practices can expand the range of people that a person can feel compassion for. Ilian Daskalov is a senior undergraduate student at University of California, Irvine where he studies Cognitive Science. He holds an associate degree with honors from San Diego Mesa College. His research interests include sleep, psychedelics, and artificial intelligence. He is passionate about communicating science and promoting critical thinking.  Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks.   Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting.   He teaches science. It keeps him out of trouble.   Get a 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace Theory GO TO: http://shop.thenautiluspress.com APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP"

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices.In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA: Altered States of the Human Mind: Implications for Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37000]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices.In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices.In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36669]

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.316646v1?rss=1 Authors: Goulas, A., Changeux, J.-P., Wagstyl, K., Amunts, K., Palomero-Gallagher, N., Hilgetag, C. C. Abstract: Transmitter receptors constitute a key component of the molecular machinery for inter-cellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distil these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization, and a sensory-to association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density), excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density) and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization. Copy rights belong to original authors. Visit the link for more info

Jean-Pierre Changeux reflects on his scientific journey and shares insights into his research with Dr. William Mobley. This wide-ranging discussion takes a deeper look into Changeux's early work with bacteria to more recent findings on the chemistry of consciousness. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 29376]