Podcasts about Cognition

durée : 00:05:20 - Avec sciences - par : Alexandra Delbot - Les mots peuvent-ils faire frissonner le cerveau ? Une nouvelle étude montre que lire des mots désagréables comme "je grelotte" ou "je brûle" active l'insula, région qui traite habituellement ces sensations pour de vrai. Le cerveau réagit à la lecture comme s'il vivait véritablement l'expérience. - invités : Marcela Perrone-Bertolotti Maîtresse de conférence à l'Université Grenoble Alpes et chercheuse au laboratoire de psychologie et neurocognition

Is testosterone the "missing piece" of your hormone puzzle, or is it a social media-fueled performance enhancer? In this deep-dive episode, Dr. Rachel Pope is joined by Dr. Tami Rowen, a lead gynecologist at UCSF and expert in sexual and transgender health, to separate data from hype.They tackle the confusing world of testosterone for women—from its role in desire and energy to the hidden history of how it was once used to protect the uterus.In This Episode, We Discuss: The HSDD Breakthrough: Why the best-known data for testosterone is in treating Hypoactive Sexual Desire Disorder (HSDD), and the surprising truth about the doses used in successful clinical trials. The "Menopause Cliff" Myth: Why testosterone doesn't actually crash at menopause, but rather begins a slow, steady decline in your 30s. Dosing & Safety: The difference between "physiologic" levels (what you had in your 20s) and "supra-physiologic" doses (performance-enhancing levels) often seen in boutique pellet clinics. The Breast Cancer Debate: Is testosterone protective or risky? Dr. Rowen explains the "anti-proliferative" nature of the hormone and the nuances of aromatization into estrogen. The "Estratest" History: A look back at why we once used estrogen and testosterone together to protect the uterine lining—long before progesterone became the standard. Cognition, Mood, & Muscle: Does it actually help with brain fog or gym gains? We look at why the data is mixed and the power of the "placebo effect." The FDA Gap: Why the U.S. still lacks a testosterone product specifically approved for women and what that means for your prescriptions.Key Resources & Mentions: ISSWISH: International Society for the Study of Women's Sexual Health Dr. Tami Rowen: UCSF Health Profile Research Study: The Women's Health Initiative (WHI) and the 300mcg testosterone patch trials.About Our Guest:Dr. Tami Rowen is a board-certified OB/GYN and Associate Professor at UCSF. She is a nationally recognized expert in sexual medicine, transgender health, and complex gynecological care for cancer survivors.If you found this episode helpful, please Rate, Review, and Subscribe on Apple Podcasts or Spotify! Your support helps us bring this vital information to more women.Follow Dr. Rachel Pope: Instagram: @DrRachelPope Website: OurWomanity.com

In this Huberman Lab Essentials episode, I discuss the mechanisms through which deliberate heat exposure enhances both physical and mental health. I outline specific protocols for deliberate heat exposure, including recommended temperature ranges, frequency, timing, duration and sauna alternatives. In addition, I explain how to tailor your heat protocols to support your specific goals, such as increasing growth hormone, reducing cortisol or supporting cognitive health. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Heat Exposure (00:00:47) Shell vs Core Temperature; Heat Caution & Hyperthermia (00:02:24) Body & Brain Circuit to Heat Up & Cool Down (00:05:31) Sponsor: AG1 (00:06:55) Deliberate Heat Exposure & Health Benefits; Tool: Sauna Temperature Range, Duration, Frequency (00:112:09) Sauna Types, Alternatives to Sauna (00:13:50) Sauna Mechanism; Reduced Cortisol; Tool: Hot/Cold Contrast (00:17:38) Sponsor: LMNT (00:19:10) Heat Shock Protein Activation & Sauna (00:20:50) DNA Repair, FOXO3 & Sauna, Cognition & Health Benefits (00:24:21) Sauna & Increase Growth Hormone (00:30:18) Sponsor: Eight Sleep (00:31:36) Sauna Timing, Sleep & Growth Hormone, Tools: Fasting; Hydration (00:34:56) Improve Mood, Endorphins & Sauna; Dynorphins (00:40:04) Recap Sauna Protocols: Benefits, Frequency, Duration & Timing Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

What if everything we've been taught about illness only tells half the story? In this episode, Darin dives into one of the most controversial debates in the history of modern medicine: germ theory versus terrain theory. While conventional medicine focuses on identifying pathogens and eliminating them, terrain theory asks a deeper question, why do some people get sick while others exposed to the same pathogen remain perfectly healthy? Tracing the history from Louis Pasteur and Antoine Béchamp to the economic forces that shaped the modern medical system, Darin explores how our internal biological environment, our terrain, may be the real determining factor in health and disease. From cellular voltage and mitochondrial function to microbiome diversity, inflammation, nutrition, toxins, and stress physiology, the science increasingly points toward one central truth: health is shaped by the environment inside the body. Most importantly, Darin breaks down the practical pillars of terrain optimization, simple but powerful daily choices that strengthen resilience, support immunity, and restore the body's natural balance. What You'll Learn The historical battle between germ theory and terrain theory Why exposure to pathogens does not automatically lead to disease The role of Louis Pasteur, Antoine Béchamp, and Claude Bernard in shaping modern medicine How the Flexner Report of 1910 reshaped medical education and marginalized holistic medicine Why modern healthcare often focuses on pathogens instead of the body's internal environment The importance of cellular voltage and mitochondrial health in disease prevention How the microbiome influences immunity, metabolism, and inflammation The surprising connection between vitamin D levels and immune resilience Why chronic inflammation is a central driver of modern diseases How stress, toxins, sleep, and nutrition shape the body's terrain The science behind grounding, sunlight, and circadian rhythm regulation Practical strategies for optimizing your internal terrain and strengthening resilience Chapters 00:00:00 – Welcome to the SuperLife podcast and the mission of building health sovereignty 00:00:33 – Sponsor: reducing plastic waste with Bite toothpaste tablets 00:02:47 – Introduction to today's topic: germ theory vs terrain theory 00:03:10 – Why Darin began exploring this controversial health debate years ago 00:03:54 – What if everything we've been taught about illness is only half the story? 00:04:35 – How our internal biological environment shapes disease susceptibility 00:05:10 – The importance of optimizing the body's internal terrain 00:06:00 – Looking back to the 1800s: the scientific battle that shaped modern medicine 00:06:17 – Louis Pasteur and the rise of germ theory 00:07:20 – The successes of germ theory: antibiotics, vaccines, and sterilization 00:08:01 – Antoine Béchamp and the foundation of terrain theory 00:08:45 – The concept of microbial polymorphism and environmental adaptation 00:09:40 – When microbes become pathogenic in weakened terrain 00:10:00 – Pasteur's alleged deathbed admission: "The microbe is nothing, the terrain is everything" 00:10:45 – Claude Bernard and the concept of the internal environment 00:11:00 – The Flexner Report and the restructuring of American medical education 00:11:45 – How holistic and integrative medical schools were shut down 00:12:30 – The rise of the pharmaceutical-centered medical model 00:13:00 – Why modern doctors often receive little training in nutrition 00:13:45 – The consequences of a pathogen-centered healthcare system 00:14:00 – How economic interests influenced the trajectory of medicine 00:14:20 – Sponsor: Manna Vitality mineral support and cellular optimization 00:16:11 – The science of terrain and how it shows up across multiple disciplines 00:16:47 – Bioelectricity and the role of cellular voltage in health 00:17:20 – The transmembrane potential and healthy cellular voltage levels 00:17:50 – Otto Warburg's discovery of low oxygen environments in cancer cells 00:18:30 – Dr. Jerry Tennant's research on voltage and chronic disease 00:19:00 – The microbiome revolution in modern science 00:19:30 – Why the body contains roughly 38 trillion microbial cells 00:20:00 – How gut bacteria influence immune response 00:20:30 – Research showing microbiome diversity affects viral susceptibility 00:21:00 – Why exposure to pathogens does not always result in illness 00:21:30 – The role of nutrition, sleep, and stress in immune resilience 00:21:55 – Vitamin D deficiency as a major predictor of disease severity 00:22:30 – Chronic inflammation as the root of modern disease 00:23:00 – Mitochondria: the cellular energy system 00:23:40 – How mitochondrial dysfunction contributes to chronic illness 00:24:00 – The connection between nutrient availability and mitochondrial health 00:24:30 – The pillars of terrain optimization 00:25:00 – Why minerals are foundational for cellular health 00:25:30 – Magnesium deficiency and inflammatory disease 00:26:00 – Building a mineral-rich diet for optimal physiology 00:26:20 – Invitation to the SuperLife Patreon community 00:27:55 – Supporting the microbiome through diet and lifestyle 00:28:20 – Why dietary diversity increases microbial resilience 00:29:00 – The importance of sunlight, grounding, and circadian rhythm 00:30:00 – Sleep and the brain's detoxification system 00:31:00 – Environmental toxins and the body's detox pathways 00:31:45 – Stress physiology and its destructive impact on the terrain 00:33:00 – Rebuilding resilience through lifestyle choices 00:34:00 – Final thoughts on reclaiming control over your health 00:35:17 – Closing message and end of episode Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.   Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway: "The germ may be the match, but the terrain is the dry timber. Without the right internal conditions, the spark simply goes out. But when the terrain is depleted—when our bodies are stressed, inflamed, nutrient deficient, and toxic—that same spark can ignite disease. The power we have is in shaping the terrain every single day." Bibliography/Sources: Bai, Y., Ocampo, J., Jin, G., Chen, S., Benet-Martínez, V., Monroy, M., Anderson, C., & Keltner, D. (2021). Awe, daily stress, and well-being. Emotion, 21(4), 562–566. This research documents how individuals experiencing awe report lower levels of daily stress, putting stressors into perspective to increase overall life satisfaction. https://doi.org/10.1037/emo0000638 Becker, R. O., & Selden, G. (1985). The Body Electric: Electromagnetism and the Foundation of Life. A pioneering work documenting how bioelectric fields in the body regulate growth, healing, and immune function. https://www.amazon.com/Body-Electric-Electromagnetism-Foundation-Life/dp/0688069711 Chirico, A., & Yaden, D. B. (2018). Awe: A self-transcendent and sometimes transformative emotion. This chapter identifies awe as a complex emotion arising from vastness that facilitates connectedness and self-diminishment. https://doi.org/10.1007/978-3-319-77619-4_11 DiNicolantonio, J. J., O'Keefe, J. H., & Wilson, W. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Published in Open Heart, this study highlights how magnesium deficiency is a silent driver of inflammatory disease states. https://openheart.bmj.com/content/5/1/e000668 Keltner, D., & Haidt, J. (2003). Approaching awe, a moral, spiritual, and aesthetic emotion. Cognition and Emotion, 17(2), 297–314. A seminal paper establishing the two central pillars of awe: perceived vastness and the need for mental accommodation. https://doi.org/10.1080/02699930302297 Sender, R., Fuchs, S., & Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. Published in Cell, this study provides the current understanding that human and microbial cells exist in roughly equal numbers. https://doi.org/10.1016/j.cell.2016.01.013 Warburg, O. (1956). On the origin of cancer cells. Nobel Prize-winning research published in Science establishing that cancer thrives in low-oxygen, low-voltage environments where cellular respiration is impaired. https://doi.org/10.1126/science.123.3191.309

Menopause Mastery Show | Understanding Progesterone: Myths, Science, and Health Impacts   Progesterone in Perimenopause & Menopause: Bioidentical vs Progestins, Sleep, Cognition, and the Real Science   Welcome to Menopause Mastery! Join Dr. Betty Murray in this episode as she breaks down the science behind progesterone.  Amid online controversy, Dr. Betty explains what progesterone does in the body, how it declines first in perimenopause, and why bioidentical micronized progesterone differs from synthetic progestins used in birth control and older HRT like Prempro.    She reviews evidence that oral micronized progesterone (often ~300 mg at bedtime) can improve sleep architecture and may reduce hot flashes/night sweats, while clarifying mixed findings and underpowered studies. It addresses brain and cognition claims by separating human data (largely neutral/no cognitive harm, mood benefits) from alarming animal studies, and explains individual variability via allopregnanolone metabolism, PMDD/depression history, genetics, and route of delivery (oral vs vaginal). In addition, she discusses cardiovascular nuance, endometrial protection with estrogen, and cyclical vs continuous dosing considerations.   If you're a woman over the age of 35, and are looking for relief from hot flashes, night sweats, and disrupted sleep, this episode is for you. Please share with other women in your life that deserve to have their symptoms taken seriously!     00:00 Progesterone Controversy 01:08 Progesterone Basics 01:55 Perimenopause Decline 03:06 Progestins vs Progesterone 06:10 Hot Flashes Evidence 09:17 Sleep and Metabolites 11:39 Cardiovascular Nuance 15:18 Brain Debate Explained 16:19 Human Studies Summary 20:09 Allopregnanolone U Curve 22:15 Animal Study Misuse 25:17 Oral vs Vaginal Routes 31:27 Cycling vs Continuous 37:47 Key Takeaways Recap 41:59 Closing and Empowerment Connect with Dr. Betty Murray:  Betty Murray Website: https://www.bettymurray.com/  Instagram: https://www.instagram.com/drbettymurray/    Links:  The Fierce Female Method for Longevity (Dr. Betty's book): https://fierce.hormoneshelp.com/  Menrva Telemedicine: https://gethormonesnow.com/     FREE Hormone Quiz: https://bit.ly/3wNJOec    Living Well Dallas: https://www.livingwelldallas.com/   Hormone Reset: https://hormonereset.net/    More from the Podcast:  Subscribe to #MenopauseMastery → https://www.youtube.com/channel/UCwONPdSvb2-YYY74VhD-XBw  YouTube Video Podcast Link: https://youtu.be/QP0v2gvLr0M Apple Podcasts → https://podcasts.apple.com/us/podcast/menopause-mastery/id1607369247    Spotify → https://open.spotify.com/show/0tNsjm32CZNXSgSFEwS3uH    Thank you for listening to Menopause Mastery. Empowering your health journey, one episode at a time.

Looking at decision-making from an ecological perspective. From a mental event that follows perception and precedes action to a phenomenon that emerges from the performer-environment interaction. Links:Ecological cognition: expert decision-making behaviour in sport http://perceptionaction.com/ My Research Gate Page (pdfs of my articles) My ASU Web page Podcast Facebook page (videos, pics, etc)   Subscribe in iOS/Apple Subscribe in Anroid/Google   Support the podcast and receive bonus content   Credits: The Flamin' Groovies – ShakeSome Action Mark Lanegan - Saint Louis Elegy via freemusicarchive.org and jamendo.com

Red light therapy has benefits that go far beyond skin health. In this video, I break down five surprising ways it may support your body, including brain function, thyroid health, hair growth, joint comfort, and energy levels. You'll learn how light therapy influences cellular function and why these lesser-known benefits are gaining attention in clinical and research settings. If you're considering red light therapy, these insights may help you better understand its potential health benefits.   ✅Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/

Russell Kaplan, co-founder of Cognition — the company behind Devin — and previously at Scale AI and Tesla, joins the podcast to discuss what “software abundance” could mean for government. Our conversation covers… Why government software is so broken — Despite spending over $100B annually on IT, critical systems at agencies like the Social Security Administration and U.S. Department of the Treasury still run on decades-old code that few engineers know how to modify. How two-year software projects become three-week ones — why AI agents are particularly good at the painful migration and modernization work engineers tend to avoid. What “software abundance” actually means — AI agents can handle the tedious work of switching systems 24/7, collapsing the switching costs, and forcing software vendors to compete on value rather than locking customers into outdated systems. AI for cybersecurity — From triaging massive vulnerability backlogs to automatically fixing CVEs, AI will be essential for defending critical infrastructure as attackers gain the same tools. The coming “post-coding” world — As models converge in capability, the key bottleneck shifts from writing code to understanding problems, reviewing systems, and deciding what should be built in the first place. Plus, the future of procurement in an AI world, fraud detection in government datasets, the DMV as a software problem, and why Kaplan thinks the real skill of the future is knowing which problems matter. Thanks so much to Cognition for sponsoring this episode. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode Andrea Samadi welcomes back Dr. David Stephens to explore his new book, The Glucose Protocol, and the science showing how targeted glucose can restore brain function, improve mental clarity, and reduce symptoms linked to diabetes, autoimmune disorders, and chronic stress. They break down the difference between glucose and other sweeteners, explain why the brain prioritizes survival over higher-order thinking during stress, and share practical strategies—like on-the-spot glucose dosing—to regain focus and cognitive performance. Dr. Stephens also discusses biomarkers, clinical observations, and upcoming practical products to make brain refueling easy, offering hopeful, science-based approaches to restore long-term brain health. Watch interview on YouTube here https://youtu.be/zv70S5fZh2I Today's EP 388 we're welcoming Dr. Stephens back to the podcast to explore: The difference between glucose and other sugars Why blood sugar and brain glucose matter for cognitive performance What his newest research is revealing about brain restoration And how we can think more clearly about nutrition and brain health moving forward. Welcome back to Season 15 of the Neuroscience Meets Social and Emotional Learning Podcast. I'm Andrea Samadi, and here we bridge the science behind social and emotional learning, emotional intelligence, and practical neuroscience—so we can create measurable improvements in well-being, achievement, productivity, and results. When we launched this podcast seven years ago, it was driven by a question I had never been taught to ask— not in school, not in business, and not in life: If results matter—and they matter now more than ever—how exactly are we using our brain to make these results happen? Most of us were taught what to do. Very few of us were taught how to think under pressure, how to regulate emotion, how to sustain motivation, or even how to produce consistent results without burning out. That question led me into a deep exploration of the mind–brain–results connection—and how neuroscience applies to everyday decisions, conversations, and performance. That's why this podcast exists. Each week, we bring you leading experts to break down complex science and translate it into practical strategies that we can all apply immediately. When the brain, body, and emotions are aligned, performance stops feeling forced—and starts to feel sustainable. Season 14 showed us what alignment looks like in real life. We looked at goals and mental direction, rewiring the brain, future-ready learning and leadership, self-leadership, which ALL led us to inner alignment. And now, Season 15 is about understanding how that alignment is built—so we can build it ourselves, using predictable, science-backed principles. Because alignment doesn't happen all at once. It happens by using a sequence. And when we understand the order of that sequence — we can replicate it. By repeating this sequence over and over again, until magically (or predictably) we notice our results have changed. Season 15 we've organized as a review roadmap, where each episode explores one foundational brain system—and each phase builds on the one before it. Rather than focusing on outcomes, hacks, or motivation alone, we examine the core brain systems that must be stable before learning, performance, and leadership can emerge. Episodes are organized around a simple but powerful progression: Phase 1: Regulation & Safety — the nervous system foundation for learning Phase 2: Neurochemistry and Motivation—dopamine balance + Emotional regulation Phase 3: Cognition & Learning — attention, memory, and executive function Phase 4: Perception & Social Intelligence — how we read ourselves and others Phase 5: Integration & Meaning — how experience becomes insight and growth Each system builds upon the one beneath it, reminding us that when foundations are ignored, progress is temporary. When they are strengthened, performance becomes sustainable. Season 15 is not a review of past episodes—we are connecting neuroscience, emotional regulation, and learning into a clear framework for improved human potential. Because performance is not built from the top down. It emerges from the foundations up. PHASE 1: REGULATION & SAFETY Staples: Sleep + Stress Regulation Core Question: Is the nervous system safe enough to learn? Anchor Episodes Episode 384[i] — Baland Jalal How learning begins: curiosity, sleep, imagination, creativity Episode 385[ii] — Bruce Perry “What happened to you?” — trauma, rhythm, relational safety Episode 386 –Thoryn Stephens Turning biometrics (HRV, sleep data, metabolic markers) into actionable protocols. Episode 387 Dr. Sui Wong[iii] Autonomic balance, lifestyle medicine, brain resilience Episode 388 Rohan Dixit HRV, real-time self-regulation, nervous system literacy For today's EP 388, we welcome back Dr. David Stephens, a clinical psychologist and neuropsychologist renowned for his expertise in brain function and mental health. Discover groundbreaking insights into how glucose can be a game-changer in restoring brain function, mental health, and overall productivity. Dr. Stephens shared his compelling journey with us that led to the revelation of glucose as a crucial element in brain restoration. From understanding the perceptible differences between glucose and sugar to unraveling common myths about brain health, this conversation is packed with scientific insights that challenge traditional paradigms that explored how restoring glucose levels could revolutionize our mental, emotional, and spiritual well-being. I believe in Dr. Stephens' mission mostly because I've experienced life-changing results when I started to read labels, and cut out sugar after a podiatrist told me this would improve my health back in 2005. The results I've noticed are significant. But now, I understand sugar and glucose at a different level. I have lots of follow up questions for Dr. Stephens, and am excited to learn more about what he has discovered since we last spoke. Episode Introduction This week on The Neuroscience Meets Social and Emotional Learning Podcast, we are revisiting a past guest who joined us in December 2024 on Episode 350[iv]. Dr. David Stephens is a clinical psychologist and neuropsychologist known for his research on brain function, mental health, and the role of glucose in cognitive performance and recovery. In our previous conversation, Dr. Stephens introduced a fascinating concept: that glucose may play a far more important role in brain restoration and mental health than many of us realize. Since that interview, Dr. Stephens has continued his research and recently released new insights in his book Restored Hope, exploring how glucose regulation may influence cognitive performance, emotional stability, and overall brain health. This topic is especially meaningful to me personally. Back in 2005, a podiatrist suggested I eliminate sugar from my diet to improve my health. After making that change and becoming more mindful of reading nutrition labels, I noticed significant improvements in how I felt physically and mentally. But what I've learned since speaking with Dr. Stephens is that understanding sugar and understanding glucose are not the same thing—and that difference may change how we think about nutrition and brain health. Dr. Stephens, welcome back to the podcast. How have you been since we last spoke? Q1: Dr. Stephens, thank you for reaching back to me about your new book, and research. I'm sure you could tell that this topic is important to me. We've covered a few podcast episodes on “The Damaging Effects of Sugar on the Brain and Body” with research that came from my foot doctor, who had me change my diet in 2005, and my health turned around for the better. Can we review what should we understand about glucose, vs sucralose that is connected to weight gain and type 2 diabetes? Q2: What's important about understanding our blood sugar vs glucose levels in the brain? Q3: I've also posted a comment from our last interview that gave an overview of the definition of sucrose vs sucralose. Then I wondered, is sucralose bad for our brain? Sometimes I make sugar free hot chocolate, and I know that I once looked this up. I'm sure Dr. Daniel Amen recommends Stevia as a brain-healthy sweetener, but I'm sure I once forgot, and bought Splenda by mistake. Can you explain the difference and do you agree with Dr. Amen that we should choose Stevia over Splenda? Q4: Can you share what you have uncovered since we last spoke in December 2024? I did read what you had sent me, but I will need it translated into English. • Fructose-controlled design (with biomarker panels HRV, FDG-PET, inflammatory markers, RBANS domains). • AI assisted hypothesize generation for theory building • This book ranks Q5: I followed some of the questions that came through on the YouTube Comments since our last episode. Many were positive, and support your research but every once in a while, someone will comment something negative about this topic. I find it interesting, because the podiatrist who told me to stop eating sugar years ago said the exact same thing. He found it difficult to fight against the criticism. What have you noticed and how do you handle people who don't understand what you have uncovered? Q6: What else is important for us to understand? Q7: Some people have asked for updated information on where they can find you. Can you share the best way for people to reach you? Dr. Stephens, I believe in your mission, and look forward to reading your new book. Thank you for sharing your research with us, and look forward to hearing what from you as you write more books on this topic, to help us to take our brain health seriously. Key Takeaways from This Episode 1. The Brain Runs on Glucose Glucose is the brain's primary fuel source. When glucose regulation is disrupted, it can affect cognition, focus, emotional regulation, and mental health. 2. Not All “Sugar” Is the Same Many people use the words sugar and glucose interchangeably, but they are chemically different and can affect the body in different ways. Understanding these differences can help people make more informed nutrition decisions. 3. Artificial Sweeteners Raise Important Questions Sweeteners like sucralose (Splenda) may not behave the same way as natural glucose or other sugars in the brain and body. This is an area of ongoing research and debate, and understanding the metabolic impact of these substitutes is important. 4. Brain Health Is Deeply Connected to Metabolism Dr. Stephens' research suggests that metabolic processes, inflammation, and brain energy systems may play a much larger role in mental health and cognitive performance than we previously understood. 5. Science Evolves Through Debate Innovative research often meets skepticism. Scientific progress depends on healthy debate, continued research, and open dialogue. Listener Action Steps 1. Become Aware of Your Nutrition Labels Start reading labels and becoming more aware of added sugars, sweeteners, and ingredients in your daily diet. Small changes can have meaningful long-term effects. 2. Pay Attention to Your Brain Energy Notice how your focus, mood, and energy levels respond to different foods. Your brain's fuel matters for performance, learning, and emotional regulation. 3. Stay Curious About New Research Topics like nutrition, metabolism, and brain health are constantly evolving. Stay open to learning and questioning new findings. Just like we mention in this interview, there was a day that Andrea would not eat butter. Understanding glucose is another paradigm shift. 4. Prioritize Brain Health Holistically Nutrition is only one piece of the puzzle. Brain health is also supported by: sleep stress regulation exercise recovery social connection Closing Summary As we continue exploring the neuroscience behind health, performance, and learning, conversations like this remind us that our brain is deeply connected to the systems that fuel it. Understanding how the brain uses energy—through glucose, metabolism, and nutrition—opens new doors for improving mental clarity, emotional well-being, and long-term brain health. Dr. Stephens, thank you for returning to the podcast and for continuing to explore this important topic. For those who want to dive deeper, we'll link to Dr. Stephens' latest book that you can pre-order now, and our original conversation from Episode 350 in the show notes. Feel free to reach out directly to Dr. Stephens through his contact information below. RESOURCES: Watch our original interview here EP 350 https://youtu.be/T0R3uvBbHPE MORE ABOUT DR. STEPHENS Dr. David Stephens is a seasoned clinician and leader in issues related to mental health, who has focused his efforts over the last 15 years on neuroscience. As a former supervising psychologist at the Colorado State mental hospital and a director in correctional mental health, he brings a unique perspective to the challenges faced by individuals with mental health and substance use disorders. He is a sought-after expert in the fields of brain function, mental, and correctional mental health. His work has been instrumental in shaping policies related to mental health care within correctional settings. Dr. Stephens has spent the majority of his career training statewide directors of mental health within the correctional system on brain function as well as geriatric issues facing the nation's prisons. He served as the academic Dean of professional psychology, including both Master's and Doctoral programs. He has been interviewed several times to discuss topics related to mental health, correctional mental health, brain function, addiction, and marriage. Dr. Stephens has dedicated his life to helping educate everyone he encounters on the importance of knowing and understanding these topics. CONNECT with DR. DAVID STEPHENS  Phone:  573 590-4638  Email:  dstephens@restoredhumanity.com Website: https://www.glucoseprotocol.com/  PRE-ORDER The Glucose Protocol: A Practical and Scientific Guide to Brain Restoration of Health.  https://www.amazon.com/dp/B0GQQYNX4Z#:~:text=The%20Glucose%20Protocol,Read%20more REFERENCES: [i] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 384 “How Learning Begins in the Brain: Sleep, Safety and Curiosity (Revisiting Dr. Baland Jalal) https://andreasamadi.podbean.com/e/hypnagogic-genius-capture-your-best-ideas-at-the-edge-of-sleep/   [ii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 385 “Safety First: Why a Regulated Brain is the Key to Learning” (Revisiting Dr. Bruce Perry) https://andreasamadi.podbean.com/e/safety-first-why-a-regulated-brain-is-the-key-to-learning/   [iii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 387 with Dr. Sui Wong “Your Eyes: The Brain's Early Warning System”  https://andreasamadi.podbean.com/e/your-eyes-the-brain-s-early-warning-system/   [iv] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 350 “Unlocking Brain Health with Dr. David Stephens”  https://andreasamadi.podbean.com/e/unlocking-brain-health-with-dr-david-stevens/  

Russell Kaplan, co-founder of Cognition — the company behind Devin — and previously at Scale AI and Tesla, joins the podcast to discuss what “software abundance” could mean for government. Our conversation covers… Why government software is so broken — Despite spending over $100B annually on IT, critical systems at agencies like the Social Security Administration and U.S. Department of the Treasury still run on decades-old code that few engineers know how to modify. How two-year software projects become three-week ones — why AI agents are particularly good at the painful migration and modernization work engineers tend to avoid. What “software abundance” actually means — AI agents can handle the tedious work of switching systems 24/7, collapsing the switching costs, and forcing software vendors to compete on value rather than locking customers into outdated systems. AI for cybersecurity — From triaging massive vulnerability backlogs to automatically fixing CVEs, AI will be essential for defending critical infrastructure as attackers gain the same tools. The coming “post-coding” world — As models converge in capability, the key bottleneck shifts from writing code to understanding problems, reviewing systems, and deciding what should be built in the first place. Plus, the future of procurement in an AI world, fraud detection in government datasets, the DMV as a software problem, and why Kaplan thinks the real skill of the future is knowing which problems matter. Thanks so much to Cognition for sponsoring this episode. Learn more about your ad choices. Visit megaphone.fm/adchoices

In dieser Folge gehen Leon und Atze der wohl zerstörerischsten menschlichen Emotion auf den Grund: Hass. Was genau ist Hass – und warum empfinden wir ihn überhaupt, wenn er doch so viel Schaden anrichten kann? Was unterscheidet ihn von Wut oder Verachtung? Und warum hält er oft so lange an und richtet sich nicht selten gegen Menschen, die uns einmal besonders nah waren? Außerdem sprechen die beiden darüber, warum Hass ansteckend sein kann, welche Rolle er in gesellschaftlichen Konflikten spielt und wie er uns manchmal vielleicht sogar helfen kann. Fühlt euch gut betreut Leon & Atze Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Vorverkauf 2026: https://betreutes-fuehlen.ticket.io/ Empfehlungen Confirmation Bias – Folge von Betreutes Fühlen: Die Fehler deiner Psyche (Oktober 2023) Warum wir hassen – sechsteilige Dokumentarserie der Oscarpreisträger Steven Spielberg und Alex Gibney, die den Ursachen für zunehmende hasserfüllte Radikalisierung in Teilen der Gesellschaft nachgeht. Quellen Aumer, K., Bahn, A. C. K., Janicki, C., Guzman, N., Pierson, N., Strand, S. E., & Totlund, H. (2016). Can't let it go: Hate in interpersonal relationships. Journal of Relationships Research, 7, e2. https://doi.org/10.1017/jrr.2016.2 Baldwin, J. (1963). The fire next time. Dial Press. Ben-Ze'ev, A. (2018). Is hate worst when it is fresh? The development of hate over time. Emotion Review, 10(4), 322–324. https://doi.org/10.1177/1754073917751229 Fischer, A., Halperin, E., Canetti, D., & Jasini, A. (2018). Why we hate. Emotion Review, 10(4), 309–320. https://doi.org/10.1177/1754073917751229 Halperin, E., Russell, A. G., Dweck, C. S., & Gross, J. J. (2011). Anger, hatred, and the quest for peace: Anger can be constructive in the absence of hatred. Journal of Conflict Resolution, 55(2), 274–291. https://doi.org/10.1177/0022002710383670 Liu, Y., Olivers, C. N. L., & Van Lange, P. A. M. (2024). Love and hate do not modulate the attentional blink but improve overall performance. Cognition and Emotion, 38(7), 1001–1014. https://doi.org/10.1080/02699931.2024.2338203 McCarthy-Jones, S., Bokde, A., & de Vries, J. (2026). Hate as poison and cure? Reassessing our hatred of hatred. Emotion Review. Advance online publication. https://doi.org/10.1177/17540739261422556 Redaktion: Julia Ditzer, Dr. Leon Windscheid Produktion: Murmel Produktions

Rejoins le plus grand événement jamais organisé pour les entraineurs, préparateurs et coachs, les 13-14-15 mars à Paris : les Rencontres de la Performance.Plus de 70 intervenants autour de 6 thématiques :- Entrainement général- Préparation physique- Préparation mentale, psychologie- Cognition & motricité- Santé, récupération, nutrition- Business et développementTu trouveras des conférences, des ateliers, des tables rondes avec UN SEUL OBJECTIF : apporter des solutions aux problématiques de terrain.Tu trouveras toutes les informations ici : https://rencontres.secretsdentraineurs.com/inscription_____________Christophe a été entraineur des équipes de France de Judo durant de nombreuses olympiades. Il a occupé quasiment tous les postes et obtenu un nombre de médailles olympiques et mondiales avec ses sportives assez hallucinant !Aujourd'hui il est directeur de l'accompagnement à la haute performance au sein de la FFJudo. C'est à ce titre qu'il est venu transmettre son expérience dans cet épisode.On discute de :Des datasCommuniquer individuellement au sein d'un groupeTrouver un équilibre pro-persoGérer la concurrence interneComment annoncer des mauvaises nouvellesApprendre à observer pour mieux entrainer_____________Retrouve nous également sur les réseaux sociauxInstagram : https://www.instagram.com/secretsdentraineurs/LinkedIn : https://www.linkedin.com/in/julien-vecchione-714147155/A très vite pour un nouvel épisode !Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Dr. Natalie Atwell returns and this one cuts deep. Hormone imbalance. Chemical chaos in the brain. Mental health under silent siege. She breaks down the science behind mood swings, depression, and anxiety—then connects it to spiritual warfare most are too afraid to name. Her new book pulls no punches. If your mind's been under attack, this episode might expose why. Tune in and wake up.ENGAGE WITH DR ATWELL NOWSTAND WITH CHEF AND HIS WIFE AGAINST KIDNEY FAILUREBUY THE LIMINAL TREES BOOK NOW ☂️☂️☂️ALERT OPERATIONS: CRYPTID WARFARE GET CLEAN: DETOX AND MAKE KIDS HEALTHY AGAIN// // GET 15% OFF AT CHECK OUT USING "PARANOI" at FLAVORS OF THE FORESTTHE TREBLES SHOWTHE TREBLES SHOW

Chris talks to Matteo Tarsi from Uppsalla University lostincitations@gmail.com, haswellkyudai@gmail.com 

The new semi-autobiographical play “The Reservoir” spins a comedic narrative around cognitive reserve, the idea that doing brain-stimulating activities can prevent or delay the onset of dementia symptoms. It's currently running at the Atlantic Theater Company and co-produced by The Ensemble Studio Theater in New York.*  Host Ira Flatow talks with playwright Jake Brasch about his inspiration for the play and how to mesh science into the theater.  Then, neurologist Marilyn Albert discusses some of the latest science of mental stimulation and dementia. After following a diverse group of older adults for 20 years, her research found that a modest amount of specialized cognitive training reduced dementia risk by 25%. You can try a very similar brain training exercise at home.  *“The Reservoir” received funding from the Sloan Foundation, which also helps support Science Friday. Guests: Jake Brasch is a writer, performer, composer, clown, and writer of the new play “The Reservoir.”  Dr. Marilyn Albert is a professor of neurology and director of the Alzheimer's Disease Research Center at Johns Hopkins Medicine.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Send a textDr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he leads health education, protocol design, and health-improvement strategies. His work centers on translating cutting-edge science into actionable information and programs that support health span optimization and peak performance. Previously, Dan founded humanOS.me, a digital health platform developed with over 100 health-science professors. Its podcast, humanOS Radio, became the official podcast of the Sleep Research Society and a content partner of the Buck Institute for Research on Aging.He also served as Chief Health Architect at Restore Hyper Wellness, where he led new product strategy and served as key authority for intervention sciences.Through Vivendi Health, Dan provides bespoke consulting to individuals and organizations facing unique health challenges. He holds a PhD in Cognitive Neuroscience from Leiden University and Stanford, and a Master's in Exercise Physiology from Florida State.He's spoken at TEDx and the Institute for Human Machine Cognition, among others.Find Dr. Pardi at-https://www.qualialife.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

Episode Title: Three Somatic Questions for Locating Your Healing Progress Host: Nia Guest: Jean Dorff Episode Overview In this insightful episode of the Empowering Story Podcast, host Nia welcomes somatic healing expert Jean Dorff to explore a transformative approach to healing. Rather than viewing healing as a distant destination, Jean Dorff guides listeners through embracing healing as an ongoing process—one rooted in self-location, gentle presence, and nervous system awareness. Drawing from somatic methodologies and the Six Voice States framework, this conversation offers practical tools for tuning into the body's signals, building self-compassion, and making sustainable progress without force or self-judgment. Key Topics & Takeaways Redefining Healing: Healing isn't about arriving somewhere "better"—it's about learning to stay with yourself in the present moment, as Nia notes in the episode opening. 3 Somatic Questions for Progress: Shawn Dorff introduces three powerful questions to map your real-time healing: Where do you leave yourself? (Identifying disconnection and avoidance behaviors) Where does safety already exist? (Locating micro-moments of ease and neutrality) What truth are you holding at a distance? (Recognizing what you aren't yet ready to face) The Gap Between Knowing and Feeling: Cognitive understanding doesn't always mean emotional or bodily readiness. The nervous system's pace must be respected for true integration. Why Micro-Moments Matter: Healing is cumulative—it happens in small moments of contact, pauses for breath, and gentle self-awareness, not in major epiphanies. Permissive vs. Absolute Language: Shawn Dorff explains how gentle, "even slightly" language helps lower the nervous system's defenses, allowing for authentic presence and healing. Self-Compassion in Practice: Recognizing that avoidance and "stuckness" are intelligent adaptations—not personal failures. The tools shared support nervous system participation and self-compassion. Who Should Listen? Anyone on a healing journey seeking practical, science-informed somatic tools Therapists, coaches, and trauma-informed practitioners interested in nervous system-aware language Listeners feeling "stuck" and wanting self-understanding and compassion Notable Quotes "Healing is not a destination, but the ability to locate yourself in real time." — Jean Dorff "You can understand your pain, explain your patterns, and still feel dysregulated… Cognition outpaces nervous system readiness." — Jean Dorff "Healing is not a dramatic transformation. It is the accumulation of micro-moments of contact." — Jean Dorff Resources & Frameworks Mentioned Six Voice States Framework Concepts from somatic psychology and nervous system regulation The power of "positioning questions" for self-discovery Connect & Subscribe Thank you for joining the Empowering Story Podcast. For more episodes and resources on trauma healing, nervous system health, and embodied living, subscribe and share your feedback! Search Optimization Tags (SEO/EEAT): Somatic healing, nervous system health, trauma recovery tools, somatic psychology, self-compassion, healing journey, presence, mindfulness, micro-moments, personal growth, Shawn Dorff, Nia, Empowering Story Podcast Disclaimer: The somatic tools and perspectives shared are for self-discovery and support. They are not substitutes for clinical therapy. Always consult a qualified professional for personal mental health concerns.

Most of the questions I've been asked lately have been about my current hormone replacement regimen. So I have dedicated this episode to unpacking what I use transdermally, orally, and topically for hormone replacement therapy. As you might expect, my approach includes the basics, along with a few additional strategies. I also share a topical option for facial skin that Dr. Felice Gersh recently recommended. Stay tuned to find out what I do for hormone replacement therapy. IN THIS EPISODE, YOU WILL LEARN: What you need to optimize first, before even considering adding any additional items Why I might need to increase the dosage of my Dotti transdermal estrogen patch Why I consider estradiol the most potent estrogen our bodies make before menopause Factors that influenced my decision to prioritize estradiol therapy The role of testosterone, beyond libido Why I use progesterone The value of intra-vaginal products Why I use a compounded intra-vaginal product  What copper peptides, estriol, DMAE, and hyaluronic acid may do for aging skin Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Research Links Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial Hormone Replacement Therapy Effects of Ultra–Low-Dose Transdermal Estradiol on Cognition and Health-Related Quality of Life   Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data Treatment of skin aging with topical estrogens SCF-induced airway hyperreactivity is dependent on leukotriene production The role of dimethylaminoethanol in cosmetic dermatology The Missing lnc(RNA) between the pancreatic β-cell and diabetes

Brian Menace from the UK reveals how his team pioneered knife detection dogs—a capability that sounds impossible but is backed by solid science. Working with Dr. Tatum and researchers, they discovered that edged weapons create a unique chemical signature when in contact with human skin, distinctly different from keys, coins, or other metal objects.The training evolved from "Wild West" experimentation to scientific methodology: dogs are imprinted on the specific chemical reaction between humans and sharpened metal, then taught to discriminate against non-target items through massive exposure to various metals. Like AI, more data inputs create better pattern recognition—dogs learn to find razor blades, tactical knives, and kitchen knives while ignoring silverware and tools.Key Topics:The chemical science behind knife detectionWhy knives smell different than spoons or keysTraining methodology: imprinting and discriminationOperational deployment at UK events and schoolsAddressing false positives (screwdrivers, hammers)Why scientific validation matters for credibilityEducating decision-makers on new capabilitiesCollaboration with Texas Tech researchCritical for event security, venue operators, and anyone facing knife crime threats. Brian emphasizes this isn't science fiction—it's validated science requiring patient education and demonstration.Brian Menace Background: UK-based detection dog trainer, pioneer in knife detection discipline, works with scientific researchers including Dr. Tatum and Texas Tech to validate and refine methodology.https://knifedetectiondogs.co.uk/________________________________________

For decades, neuroscience treated the brain like a digital machine — storing information in synaptic connections and sustaining activity like a switch flipped on. But what if that model is incomplete?In this conversation, I sit down with Earl Miller, MIT professor and head of the Miller Lab, to explore a growing shift in cognitive neuroscience: the brain may compute using dynamic electrical waves.We discuss how oscillations coordinate millions of neurons, how waves interact with spikes in a two-way system, why large-scale brain organization may depend on rhythmic patterns, and what this means for artificial intelligence.If cognition isn't just stored in connections — but emerges from real-time analog wave computation — how should we rethink intelligence? TIMESTAMPS:(0:00) - Introduction: Mind-Brain Relationship Explained(0:27) - Brain as an Analog System: Dynamic Wave Computation(0:59) - 20th Century Brain Models: Connectionist Cognition(2:04) - AI Limitations from Old Brain Models(2:35) - Storing Information in Synaptic Connections(3:29) - Self-Organizing Brain & Internal Control Systems(4:29) - Brain Waves for Large-Scale Organization(5:17) - Spikes and Waves: Two-Way Brain Interaction(6:30) - Electrical Oscillations: Excitation & Inhibition Patterns(9:30) - Advantages of Wave-Based Processing over Logic Gates(11:00) - Coordinating Millions of Neurons for Attention(12:30) - Goals, Plans & Intentions Driving Brain Activity(15:30) - Real-Time Control: Synapses vs Waves Debate(18:30) - Generating New Brain Wave Patterns in Real Time(23:00) - Implications for AI & Cognitive Science(27:30) - Evolving Views on Cortical Computation & Oscillations(32:00) - High & Low Energy Phases in Brain Waves Explained(38:00) - Waves as a Mechanism for Self-Organization(44:00) - Real Analog Computation Through Wave Interactions(1:15:26) - Closing ThoughtsEPISODE LINKS:- Earl's Website: https://ekmillerlab.mit.edu/earl-miller/- Earl's Publications: https://scholar.google.com/citations?user=hv8jgk8AAAAJ&hl=en- Earl's X: https://x.com/MillerLabMIT- Earl's LinkedIn: https://www.linkedin.com/in/earlkmiller/- Cognition is an emergent property: https://doi.org/10.1016/j.cobeha.2024.101388- Analog Theory:https://loc.closertotruth.com/theory/millers-brain-waves-analog-organization-of-cortex- Cognition Emerges From Neural Dynamics Lecture: https://youtu.be/ie58Ujqy0vACONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Continuing the journey in understanding the Ecological approach to cognition by looking at Tony Chemero's book: Radical Embodied Cognitive Science. Conceptualizing cognition in terms of agent-environment dynamics instead of computation and representation. What is RECS, and where did these ideas come from? Links:Radical Embodied Cognitive Science A non‐representational approach to imagined action The dynamics of active categorical perception in an evolved model agent http://perceptionaction.com/ My Research Gate Page (pdfs of my articles) My ASU Web page Podcast Facebook page (videos, pics, etc)   Subscribe in iOS/Apple Subscribe in Anroid/Google   Support the podcast and receive bonus content   Credits: The Flamin' Groovies – ShakeSome Action Mark Lanegan - Saint Louis Elegy via freemusicarchive.org and jamendo.com

CoreStory is building code intelligence platforms that address the fundamental limitation of today's coding agents: their inability to navigate complex enterprise codebases. While foundation models excel at greenfield development, they fail at real-world engineering tasks in systems spanning millions of lines of code. CoreStory's context layer delivers a 44% improvement on SWE-bench, the industry's standard benchmark for measuring coding agent effectiveness on actual GitHub issues. In this episode of BUILDERS, I sat down with Anand Kulkarni, CEO of CoreStory, to explore how his team is enabling the shift to AI-native engineering and seeding the category of spec-driven development across Microsoft, GitHub, and Amazon. Topics Discussed: Building with GPT-3 API 18 months before ChatGPT went public Why even GPT-5 and Opus 4.5 struggle with enterprise codebases on SWE-bench The narrative shift required when selling AI pre- and post-ChatGPT CoreStory's 44% improvement in coding agent performance through context intelligence How "spec-driven development" got adopted by Microsoft, GitHub, and Amazon without formal analyst relations The parallel between JIRA monetizing Agile and CoreStory enabling AI-native engineering Three-channel distribution: direct enterprise, coding agent partnerships via MCP, and hyperscaler/GSI routes Why specs become the source of truth while code becomes disposable in the AI era GTM Lessons For B2B Founders: Match your narrative precision to technical depth: CoreStory deploys three distinct positioning strategies based on audience sophistication. For AI practitioners tracking benchmarks, they lead with "44% SWE-bench improvement"—a metric that immediately signals meaningful progress on the hardest problem in the space. For engineering leaders aware of AI tooling but not deep in the research, they focus on velocity gains and ROI metrics. For executives, they describe reverse-engineering codebases into machine-readable specs. The key insight: technical audiences dismiss vague value props, while non-technical audiences get lost in benchmark details. Map your positioning to how your audience measures success in their world. Seed category language through earned adoption, not manufactured consensus: Anand initially called their approach "requirements-driven development" before simplifying to "spec-driven development." Rather than pitching analysts, they used the term consistently in customer conversations, gave talks at GitHub Universe, and shipped demos showing the workflow. When customers naturally adopted the language and community leaders began using similar terminology independently, Microsoft and GitHub followed with their own implementations (like GitHub's SpecKit). The lesson: category language sticks when practitioners choose to use it because it clarifies their work, not because a vendor pushed it. Focus on customer adoption as proof of concept before seeking broader market validation. Position against emergent practices, not just incumbent products: CoreStory doesn't position against legacy code analysis tools—they position as the enabler of AI-native engineering, the discipline that will displace Agile. Anand's insight from watching JIRA's success: "People don't love JIRA. What they love is Agile as a way to move away from waterfall." CoreStory is betting that 10x velocity gains from AI-native practices will drive the same categorical shift. When you're early in a technology wave, attach to the practice change (how teams will work differently) rather than feature comparisons with existing tools. Movements create markets. Design channel strategy around customer problem awareness: CoreStory's three channels map to different stages of buyer sophistication. Direct enterprise comes from teams already deep in AI engineering who've hit the context limitation wall. Coding agent partnerships (via MCP integration with tools like Cognition and Factory) serve builders wanting better AI tooling who haven't diagnosed the context problem yet. Hyperscalers and GSIs distribute into modernization and maintenance projects where AI enablement is emerging as a requirement. Each channel serves a distinct buyer journey stage. Don't force one go-to-market motion—design multiple paths based on where different customer segments are in understanding the problem you solve. Navigate pre-legitimacy markets by hiding the breakthrough: Before ChatGPT, selling anything AI-driven faced immediate skepticism about whether it was "real" or just smoke and mirrors. Anand couldn't lead with AI without triggering disbelief. CoreStory focused on delivered outcomes—"here's what you'll be able to do"—with AI as the mechanism, not the message. Post-ChatGPT, the challenge flipped: everyone expects AI, but now the differentiation question becomes harder. If you're building on emerging technology before market consensus forms, deemphasize the technology until buyers have context to evaluate it. Once the market validates the technology category, shift to demonstrating your specific technical advantage within it. // Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM

Welcome to this week's Midlife Minute episode. We're focusing on the importance of having good mental health today. Statistics show that women are experiencing increased anxiety, depression, insomnia, and even suicidal thoughts during midlife, yet the stigma around mental health remains surprisingly strong. Join me as I explore the science behind this, why it's happening, and the importance of empowering yourself to demand better care. IN THIS EPISODE, YOU WILL LEARN: The issues that contribute to the midlife mental health challenges women are experiencing How sleep disruptions in perimenopause increase anxiety, depression, and irritability The metabolic and endocrine factors that can compound mood instability in midlife Why perimenopause is a neurological as well as reproductive transition The evidence-based benefits of HRT for supporting mental health The role of estrogen in brain function and emotional regulation Why HRT is especially important for women experiencing abrupt or early menopause Some practical guidance for using HRT to support mental health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2298235)  Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers (https://onlinelibrary.wiley.com/doi/10.1002/da.22391) Effects of Hormone Therapy on Cognition and Mood (https://www.fertstert.org/article/S0015-0282(14)00178-2/fulltext) Does Menopause Hormone Therapy Improve Symptoms of Depression? Findings From a Specialized Menopause Clinic  A Meta-analysis of the Effect of Hormone Replacement Therapy upon Depressed Mood (https://www.sciencedirect.com/science/article/abs/pii/S0306453096000340?via%3Dihub) The Effect of Hormone Replacement Therapy on Cognition and Mood (https://onlinelibrary.wiley.com/doi/10.1111/cen.14856)

A new study shows a sex difference in the early growth of the human brain. Does it matter?

Kender du det, at du går ind i et rum - og puf - så har du fuldstændig glemt, hvad du gik derud for?Det hedder døråbningseffekten, og det er et ret normalt fænomen. Men hvorfor sker det egentlig? Det dykker vi ned i sammen med professor i kognitionspsykologi Søren Kyllingsbæk i denne uges Brainstorm-episode, hvor vi undersøger, hvorfor vores hukommelse nogle gange svigter, og vi glemmer at gøre ting. Hvorfor husker vi nogle ting og glemmer andet - også mere vigtige ting som mødet med chefen eller at aflevere biblioteksbogen, før der vanker en bøde? Og er der noget, vi kan gøre for rent faktisk at huske, hvad det nu var, vi skulle derude i køkkenet?Det får du et konkret bud på i podcasten, hvor du også kan høre om, hvordan vores hukommelse fungerer lidt på samme måde som et hestevæddeløb. MedvirkendeSøren Kyllingsbæk, professor i kognitionspsykologi på Københavns Universitet og en af lederne i forskningscentret Cognition, Intention and Action (CoInAct), hvor de blandt andet undersøger de psykologiske mekanismer bag vores handlinger RedaktionAnne Sophie Thingsted, Nana Elving Hansen, Eva Berg Søndergaard, Christoffer Bjerre og Benjamin D'SouzaStudier, vi nævner i afsnittet Eksperimentet med de studerende, der skulle huske at lave en opgave henover juleferien Studie, der peger på, at døråbningseffekten ofte sker, når vores hjerner er travlt beskæftigede Peter Gollwitzers artikel om implementation intentions Studie om implementation intentions og  vælgeradfærd at følge en sund diæt at styre sin frygt for edderkopper  Søren Kyllingbæks studier af hestevæddeløbet mellem vores intentioner kan du læse her og her. Brainstorm er støttet af Lundbeckfonden.

Is the brain really the source of mind — or is consciousness something more deeply biological?In this conversation, Anna Ciaunica challenges neurocentrism and explores the idea that cognition may not begin with neurons at all. We examine neuroimmune coupling, pregnancy as a nested model of subjectivity, basal intelligence before brains, and the fragile embodied self revealed in depersonalization experiences.We also explore biological idealism, multiscale intelligence, and whether artificial systems can ever replicate the ontological structure of living organisms.Topics include:• Neurocentrism and its limits• Immune systems as fact-checkers for survival• Basal cognition before neurons• Pregnancy and nested subjectivity• The fragile embodied self• Depersonalization & active inference• Touch and self-other boundaries• Biological idealism explained• Ontological differences between AI and life• Multiscale intelligence and self-organizationThis episode moves from cells to selves to artificial systems — and asks whether experience might be more fundamental than we assume.TIMESTAMPS:(0:00) – Introduction & The Challenge to Brain-Centrism(4:33) – Philosophy's Role in Questioning Scientific Assumptions(8:47) – Neuroimmune Coupling & The Origins of Thought(14:56) – Pregnancy, Nested Systems & Cellular Perception(17:18) – Embodiment in Early Development(23:47) – Phenomenal vs Grounded Experience(29:46) – Fetal Sensory Processing & Early Cognition(36:20) – Layered Analogies for Cognition(40:09) – Basal Intelligence Before Neurons(46:24) – Soma-Sema Theory & Death Anxiety(51:23) – Birth, Death & Ontological Boundaries(55:25) – Depersonalization & The Fragile Self(1:03:39) – Cracks in Transparency & Self-Perception(1:10:50) – Touch, Interaction & Self-Other Boundaries(1:16:45) – The “No Body” Problem(1:21:08) – Brain ≠ Mind: The Neuroimmune Challenge(1:29:09) – Biological Idealism Explained(1:37:59) – AI vs Biological Ontology(1:46:43) – Hidden Assumptions in AI Discourse(2:00:05) – Final ThoughtsEPISODE LINKS:- Anna's Website: https://annaciaunica.fr/- Anna's X: https://x.com/AnnaCiaunica- Anna's Bluesky: https://bsky.app/profile/annaciaunica.bsky.social- Anna's Publications: https://scholar.google.com/citations?user=ZUMz7EAAAAAJ&hl=en- From Cells to Selves: https://aeon.co/essays/why-you-need-your-whole-body-from-head-to-toes-to-think- When The Self Slips: https://aeon.co/essays/what-can-depersonalisation-disorder-say-about-the-selfCONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Roger Seheult, MD of MedCram explores a UK study comparing the effects of outdoor vs indoor exercise on cognitive ability in young people. See all Dr. Seheult's videos at: https://www.medcram.com (This video was recorded on February 14th 2026 Roger Seheult, MD is the co-founder and lead professor at: www.medcram.com He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine. MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS: MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested. MEDIA CONTACT:  Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-contact Video Produced by Kyle Allred Edited by Daphne Sprinkle of Sprinkle Media Consulting, LLC FOLLOW US ON SOCIAL MEDIA: Facebook:  www.facebook.com/MedCram Twitter/X: www.twitter.com/MedCramVideos Instagram: www.instagram.com/medcram DISCLAIMER: MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #sunlight #exercise #cognition

How can two people watch the same video yet see two different things? How can two people witness the same event but arrive at two different truths about what they witnessed? How can the same evidence lead people to drastically different realities? In this episode, Dr. Jay Van Bavel at NYU explains.Kitted Executive AcademyThe Power of Us WebsiteThey Saw A GameJay Van Bavel's TwitterJay Van Bavel's WebsiteHow Minds ChangeDavid McRaney's TwitterDavid McRaney's BlueSkyYANSS TwitterNewsletterPatreon Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Helene Polatajko, PhD, OT(C), FCAOT, FCAHS, LLD(h.c.), OC, a renowned occupational therapist, researcher, and co-developer of the CO-OP Approach, joins host J.J. Mowder-Tinney for a thought-provoking conversation on how cognition can drive motor performance. Together, they explore the power of guided discovery, client-centered goals, and the surprising role of self-generated strategies in rehabilitation. From dancing to dressing to stroke recovery, you'll hear how thinking differently about movement can change what your patients are capable of. Tune in to reframe your clinical lens and get inspired to incorporate “goal-plan-do-check” into your own sessions.Learning ObjectivesAnalyze the evidence around CO-OP approaches to meaningful activities across pediatric and adult populationsApply evidence-based, practical strategies to actionably address challenges in occupationalSolve patient case scenarios involving clients with coordination or motor learning impairmentTimestamps(00:00:00) Welcome(00:00:05) Introduction to cognition and motor-based performance(00:01:20) Dr. Polatajko's background and journey in occupational therapy(00:05:30) The self-driving car(00:12:40) Cognitive orientation to daily occupational performance (CO-OP)(00:14:35) Dynamic performance analysis(00:22:15) Guided discovery(00:30:24) Generalization and transfer of skills(00:34:14) Goal-plan-do-check(00:53:25) Key takeaways and conclusionNeuro Navigators is brought to you by Medbridge. If you'd like to earn continuing education credit for listening to this episode and access bonus takeaway handouts, log in to your Medbridge account and navigate to the course where you'll find accreditation details. If applicable, complete the post-course assessment and survey to be eligible for credit. The takeaway handout on Medbridge gives you the key points mentioned in this episode, along with additional resources you can implement into your practice right away.To hear more episodes of Neuro Naviagators, visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.medbridge.com/neuro-navigators⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠If you'd like to subscribe to Medbridge, visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.medbridge.com/pricing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠IG: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/medbridgeteam/

Derek Ramirez, the first ESD (Electronic Storage Device) K9 handler in his large Southern California agency, breaks down why electronic detection is the most challenging discipline in K9 work. Despite working in a major metro area with high demand, Derek's biggest hurdle wasn't finding work—it was educating decision-makers about what ESD dogs can do.Unlike narcotics or explosives with consistent target odors, electronic devices present massive challenges: thousands of manufacturers, constantly evolving technology, and micro-level odor signatures from SD cards and circuit components. Derek explains why handlers must become experts at reading subtle behavioral changes, why "interest" often matters more than full alerts, and how missing a hidden device can mean lost evidence in child exploitation cases.Key Topics:Why the nonprofit model creates handler limitationsESD vs. narcotics detection: fundamental differencesGeneralization training across device types and manufacturersReading dogs in low-odor scenariosWhy double-blind testing is essential for ESD teamsSearch methodology: how hiding spots affect successBuilding an ESD program from 5 to 16 dogsEssential for anyone considering ESD capabilities for event security, corporate environments, or law enforcement applications where electronic device detection matters.Derek Ramirez Background: First ESD K9 handler in major SoCal agency, built program from ground up, now manages growing unit of 16 dogs, works both ESD and narcotics detection.________________________________________

Episode Overview In this episode of the Breakfast Leadership Show, Michael sits down with Ryan to explore one of the most persistent and underestimated leadership challenges: negative self-talk. The conversation centers on Ryan's newly released book on self-talk and team leadership, a seven-year project co-authored with Rhett Power and Susie Burke. What began as a belief that leaders could “defeat” negative self-talk evolved into a far more practical and honest conclusion: negative self-talk cannot be eliminated, but it can be managed. This realization shaped both the content of the book and its symbolism, including a cover that reflects the fragile, ever-present nature of our internal dialogue. For leaders navigating pressure, responsibility, and visibility, this episode reframes self-doubt not as a personal failure, but as a leadership skill gap that can be addressed with awareness and structure. Cracking Negative Self-Talk in Leadership Michael and Ryan unpack how internal dialogue directly influences leadership behavior and team culture. Leaders often assume they must project certainty at all times, but unresolved self-doubt frequently leaks into decision-making, communication, and trust. Ryan explains that the “monsters” of self-doubt live in every leader's head. The difference between effective and ineffective leadership is not the absence of these thoughts, but the ability to recognize and manage them before they shape actions and culture. For corporate leaders, founders, and people managers, the book's insights offer a language for understanding what is happening internally and why it matters externally. The Hidden Cost of Negative Self-Talk The discussion highlights how common negative self-talk truly is. Ryan references research suggesting the average person has roughly 6,200 thoughts per day, with the majority skewing negative. Left unchecked, these thoughts create a constant undercurrent of exhaustion, hesitation, and overthinking. Michael connects this to what he sees in burnout-driven leadership environments, where overthinking becomes normalized and decision fatigue spreads across teams. Leaders who struggle internally often unintentionally create cultures of second-guessing and fear. Recognizing negative self-talk is positioned not as self-indulgence, but as a leadership responsibility. Fear, Cognition, and Leadership Performance Fear emerges as a central theme in the conversation. Michael and Ryan explore how fear directly impairs cognitive performance, narrowing thinking, reducing creativity, and slowing decision-making. Ryan introduces the concept of “Edimentals,” a practical framework for addressing fear and negative self-talk. The process focuses on identifying the issue, understanding the internal “worry war,” and applying a three-step method: Catch the fear as it arises Confront it with clarity and logic Change the narrative before it drives behavior Rather than treating fear as weakness, both emphasize the importance of normalizing it. Leaders who acknowledge fear openly create safer, more resilient teams. Authentic Leadership in Times of Crisis Michael shares a personal story from the early days of the pandemic, when he abandoned a traditional reporting-style team meeting in favor of a human-centered conversation. Instead of metrics and updates, the focus shifted to personal challenges, uncertainty, and shared experience. That spontaneous decision became a turning point in building psychological safety and trust. The lesson was clear: authenticity in leadership is not a soft skill. It is a stabilizing force, especially during uncertainty. Leadership, Courage, and Human Connection The episode closes with a broader reflection on leadership and courage. Drawing from insights from Ryan's podcast, The Courageous, the conversation reframes courage as honesty rather than bravado. Both agree that sustainable leadership requires balancing strategy with humanity. Taking care of people is not separate from performance; it is the foundation of it. When leaders feel safe to be real, teams perform better, communicate more clearly, and navigate pressure with greater resilience. Listeners are encouraged to explore Ryan's work and resources for deeper guidance on courage, self-talk, and leadership under pressure. Key Takeaways Negative self-talk cannot be eliminated, but it can be managed Leaders' internal dialogue directly shapes team culture Fear reduces cognitive performance and spreads quickly through teams Normalizing fear builds trust and psychological safety Authentic leadership strengthens performance, especially in crisis Ryan shared his work through Courageous and inviting listeners to learn more at hedamentals.com and RyanBerman.com.

Walking 5,001 to 7,500 steps a day slows the buildup of tau, the brain protein linked to Alzheimer's-related decline, helping you stay sharper for years longer Older adults with elevated amyloid — a key early Alzheimer's marker — preserved memory and daily function far better when they consistently reached a moderate step range Even small increases in movement, such as moving from under 3,000 steps to 3,500 to 5,000 per day, deliver meaningful cognitive benefits without requiring intense exercise High-intensity training pushed healthy adults into metabolic dysfunction, reducing mitochondrial energy production by about 40% and disrupting blood sugar stability Finding your personal exercise "sweet spot" — enough movement to avoid inactivity without pushing into extreme training — protects both long-term brain health and daily metabolic balance

The Department of Justice has unredacted additional names in the Jeffrey Epstein files after mounting pressure from lawmakers. The Guthrie family is deploying a new strategy in the search for their missing 84-year-old mother. Federal immigration officials are testifying before Congress today, as lawmakers clash over funding for the Department of Homeland Security. US military forces have boarded a sanctioned oil tanker in the Indian Ocean, though its connection to Venezuela is unclear. Plus, a new study suggests drinking tea and coffee may help reduce the risk of a major neurodegenerative disease.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

What the heck does the brain do in Ecological Dynamics, if it isn't computing, processing, or representing? An introduction to the concept of Resonance. Articles:A Theory of Resonance: Towards an Ecological Cognitive Architecture From metaphor to theory: the role of resonance in perceptual learning http://perceptionaction.com/ My Research Gate Page (pdfs of my articles) My ASU Web page Podcast Facebook page (videos, pics, etc)   Subscribe in iOS/Apple Subscribe in Anroid/Google   Support the podcast and receive bonus content   Credits: The Flamin' Groovies – ShakeSome Action Mark Lanegan - Saint Louis Elegy via freemusicarchive.org and jamendo.com

What can the behavior of primates teach us about how humans think, learn, and navigate the world? In this episode, Dr. Francine Dolins, Assistant Professor of Psychology at the University of Michigan–Dearborn, joins us to explore how studying animal cognition reveals powerful insights into the origins of human intelligence, decision-making, and social behavior. With a Ph.D. in Cognitive Psychology and Behavioral Primatology from the University of Stirling and field experience studying lemurs, tamarins, and other primates across Madagascar, Costa Rica, and Peru, Dr. Dolins brings a unique perspective that blends ecology, psychology, and evolutionary science. Her work examines how primates understand space, form mental maps, and make complex choices in both natural environments and controlled research settings. In this episode, we explore: ·       How virtual reality is being used to study cognition in apes ·       The ways primates use landmarks and mental mapping to navigate their environments ·       What animal navigation reveals about the evolution of human intelligence and cooperation ·       How comparative psychology helps us better understand social behavior and decision-making Dr. Dolins collaborates with researchers around the world, combining fieldwork, technology, and behavioral science to support conservation, animal welfare, and education. If you're curious about how studying our closest relatives can help us better understand the human mind, this conversation offers fascinating insights into the science behind cognition and behavior. Learn more about Dr. Dolins and her work here. Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

Many patients will affirm seeing clouds shaped like animals or other similar phenomena, which is why confirming pareidolia (seeing meaningful images in meaningless visual stimuli) is such a tricky symptom in dementia with Lewy bodies (DLB). While it may not be exclusive to DLB, placing such symptoms in the context of "the company it keeps" is a key method to narrowing down the diagnosis. The Editors' Choice paper for the February 2026 issue of Practical Neurology is a practical guide to the clinical diagnosis and management of DLB. Authors Dr. Sarah Fullam¹ ² and Dr. Seán O'Dowd¹ ³ join PN podcast editor Dr. Amy Ross Russell to discuss their work. They describe the importance of the initial examination, from the patient's gait to difficulties in word retrieval. They also touch on challenges in the use of biomarkers, which drugs may be helpful, and how to advise patients and their carers. Read the paper: Dementia with Lewy bodies: a practical guide to clinical diagnosis and management Special thanks to The Podcast Studios Dublin for their assistance with the recording of this episode. (1) Tallaght Institute of Memory and Cognition, Tallaght University Hospital, Dublin, Ireland (2) Trinity College Dublin School of Medicine, Dublin, Ireland (3) Trinity College Dublin Academic Unit of Neurology, Dublin, Ireland Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest episodes. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. This episode was hosted by PN's podcast editor Dr. Amy Ross Russell. Production by Amy Ross Russell and  Brian O'Toole. Editing by Brian O'Toole. Thank you for listening.

Dr. Kathryn Paige Harden, PhD, is a psychologist, behavioral geneticist and professor of psychology at the University of Texas at Austin. We discuss how genes interact with your upbringing to shape your level of risk-taking and morality. We also discuss how genes shape propensity for addiction and impulsivity in males versus females. Finally, we discuss how biology impacts societal views of sinning, punishment and forgiveness. Read the episode show notes at hubermanlab.com. Pre-order Protocols: https://go.hubermanlab.com/protocols Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Lingo: https://hellolingo.com/huberman Our Place: https://fromourplace.com/huberman Helix Sleep: https://helixsleep.com/huberman Timestamps (00:00:00) Kathryn Paige Harden (00:03:10) Adolescents, Genes & Life Trajectory; Adolescence Ages (00:06:44) Puberty, Aging & Differences; Epigenome; Cognition (00:14:05) Sponsors: BetterHelp & Lingo (00:16:45) Puberty Onset & Family; Communication & Empathy (00:22:26) 7 Deadly Sins, Substance Use & Conduct Disorders, Genes (00:27:33) Family History; Genes & Brain Development (00:33:05) Personality & Temperament, Motivation, Addiction; Trauma (00:37:59) Knowing Genetic Risk & Outcomes; Understanding Family History (00:46:06) Sponsor: AG1 (00:46:57) Genetic Information & Decision Making; Personal Identity & Uncovering Family (00:52:12) Nature vs Nurture, Bad Genes?; Aggression, Childhood & Males (01:00:17) The Original Sin; Whitman Case & Brain Tumor; Genetic Predisposition (01:10:31) Free Will; Genes & Moral Judgement; Skillful Care for Kids; Social Cooperation (01:21:03) Breaking the Cycle; Genetic Recombination & Differences; Identity (01:25:21) Sponsor: Our Place (01:27:01) Status, Dominance, Science; Positive Attributes of Negative Traits (01:36:15) Relational Aggression & Girls; Male-Female Differences & Conflict (01:40:36) Genes, Boys vs Girls, Impulse Control (01:45:00) Behavior Punishment vs Rewards, Responsibility (01:51:29) Sponsor: Helix Sleep (01:53:03) Accountability; Suffering, Cancel Culture & Punishment (02:00:01) Life Energy & Punishment, Prison (02:08:16) Backward vs Forward-Looking Justice; Forgiveness, Retribution, Power, Choice (02:16:11) Reward, Unfairness & Inequality (02:21:59) Punishment, Reward & Power; Online vs In-Person Communities (02:29:49) Identical Twin Differences; Genetic Influence & Age; Sunlight & Genes (02:39:24) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us a textThe brain's mysterious claustrum region, its role in cognitive flexibility, and how substances like alcohol and psychedelics affect neural circuits and behavior. Not medical advice.TOPICS DISCUSSED:Cerebral cortex structure: Described as a six-layered structure with pyramidal neurons and inhibitory interneurons; information flows between layers and regions to process sensory input and enable complex behaviors.Claustrum anatomy & connectivity: A sheet-like subcortical structure embedded in white matter, bidirectionally connected to cortical areas, especially prefrontal regions in rodents, with broader connections in primates and humans suggesting an integrative role.Claustrum function in cognition: Experiments show claustrum activation during task switches from easy to demanding modes, synchronizing cortical networks via inhibition and rebound excitation, potentially enabling flexible behavior.Mouse models in neuroscience: Mice are used for genetic tractability to manipulate and monitor specific circuits, revealing claustrum's role in vigilance tasks but not simple ones.Alcohol's effects on brain circuits: Chronic alcohol promotes inflexible behaviors by altering striatal interneurons and inhibitory inputs, leading to compulsive drinking despite aversive consequences.Psychedelics & brain networks: Psilocybin disrupts default mode and other networks, inhibits claustrum via serotonin 1B receptors, with effects persisting 24 hours, possibly contributing to therapeutic benefits.Evolution of claustrum: Connectivity expands from rodents to humans, shifting from cognitive-specific to broader network control, including anti-correlated states like default mode versus task-engaged.Integration of claustrum & basal ganglia: Claustrum funnels prefrontal signals to basal ganglia for action selection; alcohol may impair this, exacerbating inflexibility in addiction.ABOUT THE GUEST: Brian, PhD is a professor in the Department of Pharmacology and Physiology at the University of Maryland School of Medicine, where he leads a neuroscience lab studying brain circuits underlying flexible and inflexible behaviors using mouse models, with a focus on alcohol use disorder.Support the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

In today's world, our brains are overloaded with information, making it hard to focus and remember. But what are the true limits of the human mind—and why do they exist? And why are some people seem so much better than remembering things than others? In this episode, we talk with with Edward Awh, a cognitive neuroscientist and professor of psychology at the University of Chicago. Whose lab studies how the brain controls focus, memory and attention.His research explores the connection between attention and working memory, why our conscious awareness is far more limited than it feels, and what those limits mean for life in an information-saturated world. He explains what we can actually do to improve our memory—including one easy thing we can all do every day—and how using the “remote control of your mind” could help you focus your attention, given the limited space in our brains. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Practically Healthy, Dr. Melina Jampolis sits down with cognition dietitian Barbie Boules, RDN, to talk about how women can protect their brain health in midlife and beyond. They break down the real science behind menopause, hormones, cardiometabolic health, sleep, exercise, and nutrition for dementia prevention — without the biohacking hype. You'll learn why midlife is a critical window for brain health, how everyday habits like strength training, fiber intake, and quality sleep make a difference, and what the evidence actually says about supplements, hormone therapy, and GLP-1 medications. Practical, realistic, and evidence-based — this episode is all about doable steps for a healthier brain and body. For more great brain (and body) info, follow Barbie on IG @the_cognition_dietician

In this week's episode of High on Home Grown, we're digging into some serious research, real-world consequences, and important policy movement: Macky opens with a study shared by Cromag on Discord, looking at cannabis use before and after legalisation in Canada and how it intersects with mental health status. Published in The Lancet Regional Health, it's a data-heavy piece that adds much-needed context to an often oversimplified debate. Dr. Margaret follows with another fascinating study suggesting that lifetime cannabis use may be linked to greater cognitive performance in aging populations. Challenging long-held assumptions about long-term effects and brain health. We also look at reports that “High January” is fuelling a cannabis boom, while experts simultaneously flag potential health concerns. A reminder that growth, access, and responsibility all need to move forward together. John brings positive news from Mississippi, where lawmakers have approved a bill allowing medical marijuana use in hospitals for terminally ill patients. A meaningful step toward compassion-led healthcare. And Smee closes with a sobering story from The Independent, where a man suffered life-changing burns following an explosion at a suspected cannabis farm. Something that makes the panel sceptical of this claim! Another packed episode blending science, policy, progress, and the risks that still come with prohibition-era realities.

In this episode of Talking Sleep, host Dr. Seema Khosla welcomes three members of the World Sleep Society's consumer health technology task force—Dr. Michael Chee,  Professor and Director of the Center for Sleep and Cognition at the National University of Singapore who chaired the guideline-writing task force; Dr. Mathias Baumert, an associate professor leading the biomedical engineering discipline of the school of Electrical and Mechanical engineering at Adelaide University in Australia, and Dr. Cathy Goldstein, professor of neurology at the University of Michigan.  to discuss their global recommendations for the use of consumer sleep technology and wearable health trackers. Consumer wearables have become ubiquitous in clinical practice, with patients routinely sharing device data. While some clinicians have historically dismissed this information, attitudes are shifting as technology improves and rigorous research examines sensors, algorithms, and data quality. Dr. Chee explains that the recommendations are designed for multiple audiences: end-users, clinicians, researchers, and manufacturers, with specific guidance for each group. The conversation addresses practical considerations: the assumption that users have good perfusion, how bed partners can influence movement detection, and the fundamental truth that the best device is one patients will actually wear properly. The panel discusses recent FDA regulatory changes and clarifies whether guidance applies only to non-FDA cleared wellness devices or has broader implications. The experts systematically review various metrics from wearables. They introduce TATS (total attempted time in sleep) and explain what clinicians should know about sleep onset and offset detection. The episode emphasizes the call for standardized Fundamental Sleep Measures and greater transparency about test populations used in device validation. Dr. Baumert discusses the need to co-create benchmarks for measurement accuracy across different contexts—from persons with normal sleep to shift workers to those with sleep disorders. Whether you're skeptical about consumer wearables or seeking guidance on interpreting patient-generated data, this episode provides evidence-based recommendations for moving forward responsibly. Join us for this important discussion about embracing consumer sleep technology while maintaining clinical rigor.

Hank Wong, veteran law enforcement K9 handler turned DHS contractor, reveals shocking findings from government READY events that test bomb dog teams nationwide: NO team passes odor recognition tests 100% correctly on first attempt. The culprit? Over-reliance on single training kits and lack of exposure to varied manufacturers, packaging, and storage methods.Cameron and Hank break down the critical difference between discrimination (target vs. non-target) and generalization (recognizing target across variations), exposing how most handlers excel at one while failing the other. They discuss why dogs alert to "their version" of explosives but miss real-world threats, how training culture creates false confidence, and what event security teams must do differently.Key Topics:Why training on one kit creates operational gapsThe "chaos factor" science can't measureAction-on-find procedures for security vs. law enforcementHow to read your dog in low-odor scenariosWhy double-blind testing is essentialDiscrimination vs. generalization trainingEssential listening for event security K9 teams, handlers, and anyone responsible for explosive detection programs.Hank Wong Background: 20+ year LE K9 handler (Orlando area), worked dogs Recon, Gunner, Smash, and Keno. Now DHS contractor conducting READY events nationwide, bridging science and practitioner perspectives.________________________________________

Is it true that there is no cognition in the ecological approach to skill? No, of course not. In this episode, I want to start a series of episodes to explain how we can understand cognition (e.g., problem solving, memory, intention, agency, anticipation, decision making, etc) from an ecological viewpoint. Articles:The ecological dynamics of cognizant action in sport http://perceptionaction.com/ My Research Gate Page (pdfs of my articles) My ASU Web page Podcast Facebook page (videos, pics, etc)   Subscribe in iOS/Apple Subscribe in Anroid/Google   Support the podcast and receive bonus content   Credits: The Flamin' Groovies – ShakeSome Action Mark Lanegan - Saint Louis Elegy via freemusicarchive.org and jamendo.com

Walking 5,001 to 7,500 steps a day slows the buildup of tau, the brain protein linked to Alzheimer's-related decline, helping you stay sharper for years longer Older adults with elevated amyloid — a key early Alzheimer's marker — preserved memory and daily function far better when they consistently reached a moderate step range Even small increases in movement, such as moving from under 3,000 steps to 3,500 to 5,000 per day, deliver meaningful cognitive benefits without requiring intense exercise High-intensity training pushed healthy adults into metabolic dysfunction, reducing mitochondrial energy production by about 40% and disrupting blood sugar stability Finding your personal exercise "sweet spot" — enough movement to avoid inactivity without pushing into extreme training — protects both long-term brain health and daily metabolic balance

Dr. Michael Levin (@drmichaellevin) is the Vannevar Bush Distinguished Professor of Biology at Tufts University and director of the Allen Discovery Center. He is primarily interested in how intelligence self-organizes in a diverse range of natural, engineered, and hybrid embodiments. Applied to the collective intelligence of cell groups undergoing morphogenesis, these ideas have allowed the Levin Lab to develop new applications in birth defects, organ regeneration, and cancer suppression.This episode is brought to you by:ShipStation shipping software: ShipStation.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimOur Place's Titanium Always Pan® Pro using nonstick technology that's coating-free and made without PFAS, otherwise known as “forever chemicals”: FromOurPlace.com/TimTIMESTAMPS:[00:00:00] Start[00:03:18] The Body Electric: A Vancouver bookstore discovery that launched a career.[00:04:19] Bioelectricity 101: Your brain uses it to think; your body used it before you had a brain.[00:06:05] The lesson learned by scrambled tadpole faces that rearrange themselves.[00:08:51] Software vs. hardware: The genome is your factory settings, not your destiny.[00:11:43] Two-headed flatworms: Rewriting biological memory without touching DNA.[00:16:20] Seeing memories: Voltage-sensitive dyes reveal the body's hidden blueprints.[00:20:12] Three killer apps for humans: Birth defects, regeneration, and cancer.[00:24:27] Cancer as identity crisis: Cells forgetting they're part of a team.[00:25:40] The boredom theory of aging: Goal-seeking systems with nothing left to do.[00:30:09] Planaria's immortality hack: Rip yourself in half every two weeks.[00:31:27] Manhattan Project for aging: Crack cellular cognition, everything else falls into place.[00:33:47] Giving cells new goals: Convince a gut to become an eye.[00:37:42] Must mammalian mortality be mandatory?[00:40:25] Cross-pollination: Why biologists would benefit from programming courses.[00:47:15] Does acupuncture actually do anything?[00:50:57] Placebo as feature, not bug: Words and drugs share the same mechanism.[00:55:06] The frame problem: Why robots explode and rats intuit what matters.[00:59:41] Binary thinking is a trap: “Is it intelligent?” is the wrong question.[01:07:46] Minimal brain, normal IQ: Clinical cases that break neuroscience.[01:08:45] Super panpsychism: Your liver might have opinions.[01:13:48] The Platonic space: Bodies as thin clients for patterns from elsewhere.[01:15:24] Keep asking “why” and you end up in the math department.[01:23:07] Polycomputing: Sorting algorithms secretly doing side quests.[01:28:24] Power scaling for the future and avoiding red herrings for understanding machine minds.[01:34:06] Sci-fi recommendations.[01:37:24] Cliff Tabin's toast and Dan Dennett's steel manning.[01:41:21] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, my guest is Dr. Wendy Suzuki, PhD, a professor of neural science and psychology at New York University. We discuss simple, daily habits to improve focus, memory and overall cognitive performance. Dr. Suzuki explains how exercise directly enhances brain function—both the immediate benefits of a single workout and long-term support for cognitive health. We also discuss how meditation, verbal affirmations, sleep and other behavioral practices positively influence mood and stress regulation. Episode show notes: https://go.hubermanlab.com/7gTmlIR Join the Huberman Lab Neural Network Newsletter: https://www.hubermanlab.com/newsletter Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Wendy Suzuki (00:00:21) What Makes Moments Memorable? (00:02:24) Memory & Hippocampus, Imagination (00:05:35) Sponsor: BetterHelp (00:06:37) One-Trial Learning, Fear (00:08:10) Exercise Effects on Focus, Attention & Memory (00:12:31) Brain-Derived Neurotrophic Factor (BDNF) & Exercise (00:15:10) Sponsor: AG1 (00:16:55) Tools: Cardiovascular Exercise; 10-Minute Walk & Mood (00:18:43) How Exercise Increases BDNF (00:20:47) Adults, Neuron Growth, Hippocampus (00:22:51) Exercise Effects on Memory, Tool: Morning Exercise (00:26:08) Exercise & Long-term Effects on Cognition, Older Adults (00:27:56) Minimum Exercise For Cognitive Benefits (Adults, 30s-50s) (00:32:03) Sponsor: Eight Sleep (00:33:22) Increase Exercise For Greater Cognitive Benefits (00:35:30) Affirmations, Exercise, Mood, IntenSati (00:37:37) Meditation & Benefits, Tool: Brief Meditation (00:39:32) Tools to Improve Attention Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

We've got @GigiYoung back to talk a little bit about what may be on tap for humanity in 2026, along with a few other big topics. First, what value does the concept of 'Might Makes Right' hold for us? Is it incumbent upon us to re-pair might with morality in order to save the West? I would also like to revisit the topic of Free Will, and how it relates to things like Pre-Cognition. Should be a great first hour, and then I need to make time for calls in the second half because the topics are rich and it has been too long since we were able to get a proper open lines segment in! Unleash Your Brain w/ Keto Brainz Nootropic 15% OFF w/ code JANUARY: https://tinyurl.com/2cess6y7 And a FREE BAG of Creatine with Orders over $100 E-Mail to Request for FREE SAMPLES! Sponsor Monthly for VIP Perks: https://www.quitefrankly.tv/sponsor One-Time Tip: http://www.paypal.me/QuiteFranklyLive Quite Frankly Amazon Storefront: https://amazon.com/shop/quitefranklyofficial Official Coffee & Mugs: https://www.coffeerevolution.shop/category/quite-frankly Official QF MERCH: https://tinyurl.com/f3kbkr4s Gold & Silver: https://quitefrankly.gold Send Holiday cards, Letters, and other small gifts, to the Quite Frankly P.O. Box! Quite Frankly 222 Purchase Street, #105 Rye, NY, 10580 Tip in Crypto: BTC: bc1q97w5aazjf7pjjl50n42kdmj9pqyn5zndwh3lng XRP: rnES2vQV6d2jLpavzf7y97XD4AfK1MjePu Quite Frankly Socials: Twitter/X: @QuiteFranklyTV Instagram: @QuiteFranklyOfficial Discord Chat: https://discord.gg/xPu7YEXXRY Official Forum: https://tinyurl.com/k89p88s8 Telegram: https://t.me/quitefranklytv Streaming Live On: QuiteFrankly.tv (Powered by Foxhole) Youtube: https://tinyurl.com/yc2cn395 Rumble: https://tinyurl.com/yeytwwyz Kick: https://kick.com/quitefranklytv Twitch: https://www.twitch.tv/quitefranklylive Audio On Demand: Spotify: https://spoti.fi/301gcES iTunes: http://apple.co/2dMURMq SoundCloud: https://tinyurl.com/yc44m474

Dr. Dominic D'Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by:Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.