Podcasts about onchocerca

Ready to really feel your skin crawl? Then this month's episode on Onchocerca volvulus, a parasite that is able to infiltrate into the eye and skin to cause intense itching and blindness, might just be the one for you! We'll learn all about why this communicable disease earned the nickname "River Blindness", its mysterious linkage to seizures, the awesome powers of ivermectin (when it's actually used for diseases it can treat), and how exactly a donkey falling into a river has helped hundreds of thousands of people. Tune in to learn more about the epidemiology, biology, and history of this infectious disease! Website: www.infectiouscast.com Twitter: @infectiouscast Instagram: @infectiouscast

Welcome to the show notes for the sixth episode of the Loathsome Things Podcast! In the northern Taiga Cordillera, some dudes found something strange between bouts of playing cards and drinking, so they did the only natural thing to do: get some other dude to come here. Enter Black Mountain Side, a movie that, at its heart, is about male friendship, fellowship, and camaraderie. Also getting in on the feel-good action is a Lovecraftian deity that manifests as a deer standing up on its hind (get it!) legs. What a wacky crew! Go enjoy yourself a watch of this lovely low-budget flick, then listen in as we discuss all the zany antics in this episode of Loathsome Things!   If you would like to recommend a movie, tell us more things about Onchocerca volvulus, congratulate us for spelling “camaraderie” correctly on the first try, or tell us where we can go to find classy antique furniture under the ice, you can do so by reaching out to us on Twitter: @LoathsomePod Instagram: @LoathsomePod Facebook: @LoathsomePodcast This episode is brought to you by Hotty's Medical-grade Fireplace Equipment Manufacturing Ltd. What's that smell? I don't know, but it's almost certainly not the smell of an infected wound! Use promo code #tinyoctopuses to get a free fireplace shovel with the purchase of any deluxe, sub-freezing-ready fireplace sets.

In this classic TPWKY episode we travel down rivers and into worm-laden nodes as we take a look at the complex world of Onchocerca volvulus, the vector-borne parasite that causes river blindness. Join us as we learn why the name ‘river blindness’ captures only one dimension of the devastation caused by this parasite, how the short evolutionary history of this worm is at once surprising and enlightening, and why grasping the disease ecology of this system has been crucial in successful control efforts. As a bonus, if you tune in, you’ll get to hear how on earth The J. Geils Band fits into this story and the integral role that dog digestion has played in the history of this parasite. See omnystudio.com/listener for privacy information.

This episode covers onchocerca volvulus!

GUYS. We're back and it's the most paranormal month of the year! Tune in to hear about how the Zombie Apocalypse is definitely inevitable and all about crazy drugs that apparently you can only get in Florida.  email us! stories@zeropercentscared.com The Serpent and the Rainbow Tetrodotoxin, the Zombie drug Clairvius Narcisse Three Haitian Zombie Medical Stories Key and Peele - White Zombies CDC Zombie Preparedness   Zombie research society  Why? The Podcast: Zombie Research Society  Smith T., Zombie infections: epidemiology, treatment and prevention. (2015) BMJ  What's a prion?  Steven Schlozman - The Zombie Autopsies: Secret Notebooks from the Apocalypse  Pandemic Plague inc Top places to live in zombie apocalypse  Dead Snow: Zombie NAZIS!!! Crazy Florida Drug Zombies Rudy Eugene story Flakka the insane zombie drug Johnson et al., Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. (2017) Science Translational Medicine  Scopolamine Kuru  Zombie pig brains 

It’s the second episode of Infested! Let’s dive into an insect everyone loves to hate and a disease that will make your skin crawl. Yep,  we are talking about pesky blackflies and the almost-eradicated disease they transmit: River blindness! Buckle in for all the entomology & vector-borne disease goodness along with a global health tale showing the value of vector control and multinational cooperation. Women for Women International Books  Comstock, J. H. (1949). An introduction to entomology. Retrieved from http://archive.org/details/introductiontoen1949coms Peer Reviewed Journal Articles Boussinesq, M. (2018). A new powerful drug to combat river blindness - The Lancet. The Lancet, 392(10154), 1170–1172. https://doi.org/10.1016/S0140-6736(18)30101-6 Hall, L. R., & Pearlman, E. (1999). Pathogenesis of Onchocercal Keratitis (River Blindness). Clinical Microbiology Reviews, 12(3), 445–453. Lamberton, P. H. L., Cheke, R. A., Walker, M., Winskill, P., Crainey, J. L., Boakye, D. A., … Basañez, M.-G. (2016). Onchocerciasis transmission in Ghana: the human blood index of sibling species of the Simulium damnosum complex. Parasites & Vectors, 9(1), 432. https://doi.org/10.1186/s13071-016-1703-2 Nicholls, R. S., Duque, S., Olaya, L. A., López, M. C., Sánchez, S. B., Morales, A. L., & Palma, G. I. (2018). Elimination of onchocerciasis from Colombia: first proof of concept of river blindness elimination in the world. Parasites & Vectors, 11(1), 237. https://doi.org/10.1186/s13071-018-2821-9 Thiele, E. A., Cama, V. A., Lakwo, T., Mekasha, S., Abanyie, F., Sleshi, M., … Cantey, P. T. (2016). Detection of Onchocerca volvulus in Skin Snips by Microscopy and Real-Time Polymerase Chain Reaction: Implications for Monitoring and Evaluation Activities. The American Journal of Tropical Medicine and Hygiene, 94(4), 906–911. https://doi.org/10.4269/ajtmh.15-0695 Turner, H. C., Walker, M., Lustigman, S., Taylor, D. W., & Basáñez, M.-G. (2015). Human Onchocerciasis: Modelling the Potential Long-term Consequences of a Vaccination Programme. PLOS Neglected Tropical Diseases, 9(7), e0003938. https://doi.org/10.1371/journal.pntd.0003938 Our Social Media Follow us on Instagram and Twitter @Infestedpodcast Follow Lindsay on Twitter @Baxter.Lindsay Email us at Infestedpodcast@gmail.com This Podcast is produced and edited and researched by Lindsay and Bailey. Their views and opinions are theirs and do not reflect the institution for which they are employed. The music for this episode was provided by Lee Rosevere.   

The TWiPtomaniacs solve the case of the Boy With Visual Disturbances and Itching, and discuss identifying secreted and excreted proteins of Trichinella parasites. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Malaria plasmepsins involved in invasion and egress (Science) Image credit Letters read on TWiP 144 Case Study for TWiP 144 Individual in 30s, male, presented to physician with stomach upset, uncomfortable feeling in legs. Has motile objects in stools. From Vancouver BC, was eating salmon, reports was either dried/smoked or marinated. Not sure if this is relevant. Brought motile objects to physician. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiP Masters solve the case of the Australian Wildlife Carer, and review evidence that nodding syndrome may be caused by an autoimmune reaction to the parasitic worm that causes river blindness. Become a patron of TWiP. Links for this episode: Nodding syndrome an autoimmune disease? (Sci Transl Med) Nodding syndrome: Preventable and treatable (Sci Transl Med) River Blindness lyrics (Google Play) Image credit Letters read on TWiP 129 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twip. Case Study for TWiP 129 Young male in 30s, presents to ER with male partner, NY area, chief complaint over 1 month significant diarrhea, watery, non bloody. Abdominal cramping. Feels poorly, low energy, fever. Some vomiting, lost noticeable amount of weight, can’t stay hydrated. Past: AIDS positive, not on meds, last CD4

In der vorliegenden Arbeit wurden insgesamt 497 Patienten mit mikroskopisch gesicherten Helminthiasen hinsichtlich epidemiologischer und klinischer Daten sowie auf indirekte Laborparameter (Eosinophilie und Gesamt-IgE-Erhöhung) und die Resultate immundiagnostischer Verfahren untersucht. Hierbei wurden die Ergebnisse von 329 Reiserückkehrern und 168 Migranten mit jeweils 8 Diagnosen (Ankylostomiasis, Askariasis, Fasziolose, Filariose, Schistosomiasis, Trichinose, Trichuriasis, Mischinfektionen) miteinander verglichen. Für die Evaluation der immundiagnostischen Verfahren wurden vorhandene Seren mit 9 Antigenen (Schistosoma mansoni, Onchocerca volvulus, Dirofilaria imitis, Trichinella spiralis, Fasciola hepatica, Toxocara canis, Strongyloides ratti, Ascaris lumbricoides, Ascaris suum) getestet. Vorbestehende Ergebnisse aus der Routinediagnostik wurden mit einbezogen. Als Kontrollen dienten die Seren von 80 gesunden Personen ohne Hinweise auf eine Wurmerkrankung in der Vorgeschichte und ohne einen vorherigen Aufenthalt in den Tropen oder Subtropen. Die epidemiologischen Daten zeigen eine eindeutige Zuordnung von Schistosomiasis und Filariosen auf den afrikanischen Kontinent, während die Geohelminthiasen (Erkrankungen durch Helminthen, deren präadulte Stadien sich im Erdboden entwickeln und die eine reise- bzw. migationsmedizinisch wichtige Bedeutung haben) von den Reiserückkehrern vorwiegend in Asien, vorzugsweise in Südostasien, akquiriert wurden. Die Migranten stammten hauptanteilig aus Afrika, es waren dennoch alle wesentlichen tropischen und subtropischen Gebiete vertreten. Die Auswertung der klinischen Symptomatik zeigte ein klares Erscheinungsbild der Filariosen mit Hauterscheinungen und Juckreiz sowie die überdurchschnittlich häufige Angabe von Harnwegsbeschwerden bei Infektionen mit Schistosoma haematobium. Bei allen Geohelminthosen und Infektionen mit Schistosoma mansoni herrschte bei den Reiserückkehrern eine gastrointestinale Symptomatik vor, während die Migranten insgesamt mehr unspezifische Beschwerden aufwiesen. Circa ein Drittel der Patienten war asymptomatisch. Die Sensitivität der Eosinophilie als indirekter Parameter lag in dieser Arbeit für Wurmerkrankungen im Allgemeinen bei 45%, variierte aber von Diagnose zu Diagnose erheblich, wobei kein signifikanter Unterschied zwischen Reiserückkehrern und Migranten zu finden war. Eine Hypereosinophilie fand sich überdurchschnittlich häufig bei Migranten mit Filariose und bei Reiserückkehrern mit Strongyloidiasis; die Patienten mit Askariasis und Trichuriasis zeigten dagegen kaum Abweichungen von der Kontrollgruppe. Eine Gesamt-IgE-Erhöhung fand sich insgesamt bei 43% der Patienten, wobei es einen signifikanten Unterschied zwischen Reiserückkehrern (25%) und Migranten (75%) gab. Besonders hohe IgE-Serumspiegel konnten bei Migranten mit Schistosomiasis, Strongyloidiasis und Ankylostomiasis gefunden werden. Davon abweichend waren allerdings die Resultate von Reiserückkehrern mit Mischinfektionen. Bei diesen Patienten konnte eine unerwartet häufige Gesamt-IgE-Erhöhung verzeichnet werden (75%). Die serologischen Untersuchungen zeigten zumeist eine gute Sensitivität, aber erhebliche Kreuzreaktionen mit verwandten und nicht verwandten Wurmarten, sodass eine Differenzierung nur für die Schistosomiasis und die Filariosen valide gewährleistet ist. Der im Rahmen dieser Arbeit entwickelte Ascaris suum-ELISA, ergab eine Sensitivität von 60% und eine Spezifität von 90% und hat in der Routinediagnostik eine gewisse Berechtigung, da der Ascaris lumbricoides-ELISA inakzeptable Ergebnisse erbrachte. Zusammengefasst stellt die Eosinophilie einen wichtigen hinweisenden Parameter auf eine Wurminfektion dar, ist aber keine ausreichende Screeningmethode bei Rückkehr aus Endemiegebieten. Die serologischen Untersuchungen ergaben eine sinnvolle diagnostische Ergänzung bei der Schistosomiasis und den Filariosen. Eine Differenzierung der Geohelminthosen ist weiterhin nur durch direkte Nachweismethoden, wie z. B. dem Ei- bzw. Larvennachweis im Stuhl oder in einem Körpergewebe, verlässlich möglich.

Vincent and Dickson discuss the life cycle and pathogenesis of Onchocerca volvulus, the vector-borne filarial nematode parasite that causes onchocerciasis, or river blindness.

Background: As international travel increases, there is rising exposure to many pathogens not traditionally encountered in the resource-rich countries of the world. Filarial infections, a great problem throughout the tropics and subtropics, are relatively rare among travelers even to filaria-endemic regions of the world. The GeoSentinel Surveillance Network, a global network of medicine/travel clinics, was established in 1995 to detect morbidity trends among travelers. Principal Findings: We examined data from the GeoSentinel database to determine demographic and travel characteristics associated with filaria acquisition and to understand the differences in clinical presentation between nonendemic visitors and those born in filaria-endemic regions of the world. Filarial infections comprised 0.62% (n = 271) of all medical conditions reported to the GeoSentinel Network from travelers; 37% of patients were diagnosed with Onchocerca volvulus, 25% were infected with Loa loa, and another 25% were diagnosed with Wuchereria bancrofti. Most infections were reported from immigrants and from those immigrants returning to their county of origin ( those visiting friends and relatives); the majority of filarial infections were acquired in sub-Saharan Africa. Among the patients who were natives of filaria-nonendemic regions, 70.6% acquired their filarial infection with exposure greater than 1 month. Moreover, nonendemic visitors to filaria-endemic regions were more likely to present to GeoSentinel sites with clinically symptomatic conditions compared with those who had lifelong exposure. Significance: Codifying the filarial infections presenting to the GeoSentinel Surveillance Network has provided insights into the clinical differences seen among filaria-infected expatriates and those from endemic regions and demonstrated that O. volvulus infection can be acquired with short-term travel.