Podcasts about Schistosomiasis

Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves.  Hint: this is not Wuchereria Bancrofti. Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

In part 2, we dig into the history of pulmonary hypertension. How did this strange diagnosis first get recognized, what does it have to do with cows with thick necks and urinary catheters in the heart? Intro 0:11 In this episode 0:17 Recap of part 1 0:26 How was pulmonary hypertension discovered? 2:38 1891 3:51 1901 5:07 1935 7:02 Hilar dance 12:58 Cardiac catheterization: 1929 15:03 When did cardiac catheterization become relevant? 20:10 1965: Aminorex 24:40 World Health Organization: 1975 26:37 1980s: toxic oil syndrome of Spain 28:20 Preview of part 3 33:15  Back to cardiac catheterization 34:08 Briskets disease 35:45 1947 37:56 Pulmonary physiology and prostaglandin therapies (in the next episode) 38:41 Schistosomiasis outbreaks in Egypt 1938 40:26 Chronic thromboembolism 45:03 Thanks for listening 48:16 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Barst RJ. Ann Thorac Med. 2008;doi:10.4103/1817-1737.37832. Bodo R. J Physiol. 1928;doi:10.1113/jphysiol.1928.sp002447. Dresdale DT, et al. Am J Med. 1951;doi:10.1016/0002-9343(51)90020-4. Egypt. Stanford.edu. Published 2015. https://schisto.stanford.edu/pdf/Egypt.pdf. Hewes JL, et al. Pulm Circ. 2020;doi:10.1177/2045894019892801. Johnson S, et al. Am J Respir Crit Care Med. 2023;doi:10.1164/rccm.202302-0327SO. Newman JH. Am J Respir Crit Care Med. 2005;doi:10.1164/rccm.200505-684OE. Weir EK, et al. Circulation. 1996;doi:10.1161/01.cir.94.9.2216. Disclosures: Brown reports no relevant financial disclosures.

Die Klimakrise – Hitze, Extremwetter und Tropenerkrankungen in Deutschland Die Klimakrise verändert nicht nur das Wetter, sondern auch die medizinischen Herausforderungen in Deutschland. In dieser Folge von „O-Ton Allgemeinmedizin“ sprechen wir mit zwei Experten über die gesundheitlichen Folgen von Hitze und Extremwetter sowie das wachsende Risiko für Tropeninfektionen wie Chikungunya, Denguefieber und Schistosomiasis. • Was bedeutet die Klimakrise aus medizinischer Sicht? • Wie sollten sich Arztpraxen, Kliniken und andere Gesundheitseinrichtungen vorbereiten? • Werden wir es auch in Deutschland bald mit Tropenerkrankungen wie dem Chikungunya- und dem Denguefieber zu tun haben? • Und was hat es mit der Hyalomma-Zecke, dem Krim-Kongo-Fieber und dem Hefepilz Candida auris auf sich? Im Gespräch mit den Hosts Susanne Gallus und Tobias Stolzenberg erklären Prof. Dr. Frank Lammert, Medizinische Hochschule Hannover, und Prof. Dr. Dr. Sören Becker, Universität des Saarlandes in Homburg, worauf Ärztinnen und Ärzte in Deutschland angesichts der Klimakrise vorbereitet sein sollten. Sie beschreiben, welche Gefahren für die Menschen in Deutschland von Hitze und Extremwetter ausgehen, was Hitzeschutzpläne und Hitzeaktionspläne sind und wie real die Gefahr ist, sich in Deutschland künftig mit sogenannten Tropenkrankheiten zu infizieren. Im Podcast „O-Ton Allgemeinmedizin“ ist am 11. Juli 2024 bereits eine Folge zum Thema „Tropenkrankheiten in Deutschland“ erschienen (Staffel 3, Folge 31): https://soundcloud.com/o-ton-allgemeinmedizin Weiterführende Links DGIM – Deutsche Gesellschaft für Innere Medizin: https://www.dgim.de/ CRM – Centrum für Reisemedizin: https://crm.de/ KLUG e.V. – Deutsche Allianz Klimawandel und Gesundheit: https://www.klimawandel-gesundheit.de/ Umweltbundesamt – Hitzeaktionsplan: https://www.umweltbundesamt.de/tags/hitzeaktionsplan Heidelberger Hitzetabelle – Arzneistoffe mit potenziellem Einfluss auf die Temperaturregulation und den Volumenstatus in Hitzewellen: https://dosing.de/Hitze/Medikamentenmanagement_bei_Hitzewellen.pdf Broschürensammlung zum Thema Klimawandel, umfangreiche Mediathek: www.klima-mensch-gesundheit.de

Saint Lucia is taking a major step towards confirming the elimination of schistosomiasis, also known as bilharzia. While the prevalence of the disease is at extremely low levels with only 36 cases recorded in the past decade, the World Health Organization (WHO) requires countries to demonstrate zero cases to confirm elimination status. Therefore, the Ministry of Health, Wellness, and Elderly Affairs has made it a priority to conduct a national survey among primary school students to determine if the country is at the level of elimination. In addition, the ministry is ramping up public education efforts about schistosomiasis. 

The Ministry of Health, Wellness, and Elderly Affairs will embark on a nationwide initiative in November to assess the presence of schistosomiasis (bilharzia) among primary school children aged 8 to 11. This initiative aims to detect and address potential cases of this waterborne disease, which is transmitted through contact with contaminated water in rivers, streams, and ponds, where specific snails release the disease-causing eggs. The survey will involve a random sample of students from public primary schools across Saint Lucia. Parents will receive information packages and consent forms with full details about the survey process, and participation is entirely voluntary. To minimize any disruption to academic activities, the survey will be conducted during school hours. By undertaking this initiative, the Ministry aims to take a significant step toward safeguarding the health and well-being of Saint Lucia's youth, ensuring a healthier future for all.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Schistosomiasis⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠from the Infectious Disease section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

This week, Aebhric O'Kelly and Jason Jarvis discuss current tropical disease outbreaks in the US and Europe. The discussion went over time, so we broke the talk into two parts. Part 1: Malaria and Dengue (dropped last week) Part 2: Leishmaniasis and Schistosomiasis

This week, Aebhric O'Kelly and Jason Jarvis discuss current tropical disease outbreaks in the US and Europe. The discussion went over time, so we broke the talk into two parts. Part 1: Malaria and Dengue Part 2: Leishmaniasis and Schistosomiasis will be dropped next Friday

In this episode we will be hearing about a seven year research programme known as COUNTDOWN. COUNTDOWN consisted of multidisciplinary research teams across 4 countries- Ghana, Liberia, Nigeria and Cameroon and used co-production research approaches to improve the equity and efficiency of health systems interventions to control and eliminate seven Neglected Tropical Diseases. Research was implemented at each of the health system levels from policy to community and is all documented in the Journal ‘International Health' as a supplement entitled Stronger together: evidence for collaborative action on neglected tropical diseases. The supplement tells the story of how the programme engaged with people who have lived experience, health workers, and policy makers and really emphasises the importance of togetherness. Our guests today are Dr Luret Lar who was the programme manager employed by Sightsavers Nigeria, a collaborator on the COUNTDOWN programme, Dr Karsor Kollie who is the Program Director for Neglected Tropical Diseases at the Ministry of Health Liberia and Laura Dean from the Liverpool School of Tropical Medicine who was the Social Science lead for COUNTDOWN. Dr Laura Dean – Lecturer, Liverpool School of Tropical MedicineLaura has worked for the last 15 years in the use of participatory health research methodologies to support community and health systems development across sub-Saharan Africa and south Asia. Through participatory action research projects, she supports capacity strengthening within communities and health systems so that stakeholders can identify challenges and co-produce solutions. The majority of her work has focused on increasing inclusion and participation of people with lived experience of mental health conditions and chronic infectious diseases of poverty, for example neglected tropical diseases.Dr. Luret Lar - Medical Doctor, Public Health Physician, Lecturer, University of Jos, NigeriaLuret was involved in implementation research for seven years in collaboration with Liverpool School of Tropical Medicine when she was working for Sightsavers. Her interest and passion about preventive medicine and including the voices of the voiceless have influenced her research career over the years. Luret was interested in inclusivity at all levels of implementation in the neglected tropical diseases programme. This connected her with people affected by neglected tropical diseases and implementers at the community facility, state, and federal levels. She worked closely with these implementers to co-produce solutions to implementation challenges that everyone collectively identified.Karsor Kollie – Programme Director, Ministry of Health, LiberiaSince 2011, Mr Kollie has established and headed the Liberian Integrated NTDs Prevention and Control Programme and is based within the Ministry of Health and Social Welfare. He developed the NTD country master plan which forms the operational national guide for the next 5 years.Under his leadership the Liberian programme is making excellent progress in MDA control of Lymphatic Filariasis, Onchocerciasis, Schistosomiasis, Soil-transmitted Helminthiasis (STH) where treatment coverage has not gone below 75%, respectively. Alongside this, he is making significant progress in the development and application of new monitoring and evaluation criteria tailoring activities effectively with difficult on-the-ground terrain.More information can be found in the special supplement discussed in this episode: Stronger together: evidence for collaborative action on neglected tropical diseases | International Health | Oxford Academic (oup.com)Want to hear more podcasts like...

Parasites may bet a bad rap overall, but they play a vital role in healthy ecosystems. In this episode, we focus on the role parasites play in freshwater ecosystems. Specifically, we're talking about the role of avian schistosomes, a very interesting parasite that infects waterfowl, but that also uses snails as a host in its larval stage. Larvae also infect humans to cause what's know as swimmer's itch.To guide this conversation we have Dr. Patrick Hanington, associate professor in the School of Public Health at the University of Alberta. As a self-described parasitologist and immunologist he and his team focus on developing multiplexed PCR-based tests to detect freshwater parasites, including avian schistosomes. Their work benefits locals in his area by monitoring pubic and recreational waters for swimmer's itch outbreaks, but their work also serves as a model for informing human schistosome research, where Schistosomiasis is the second most prevalent disease worldwide, behind malaria. In our conversation with Patrick we learn about how they design their assays, why they're increasingly using dPCR instead of qPCR. Beyond the technical work, we get into how Patrick's career path developed, how what he loves most about his job has changed and evolved over time, his lessons learned in the lab, and how his research and hobbies have blended over time. And because it's Absolute Gene-ius, you know we keep it fun with some unexpected movie references and a bit of discussion about how science is represented in television and film. Visit the Absolute Gene-ius page to learn more about the guest, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.

TWiP solves the case of the case of the boy in Uganda with a mobile piece of spaghetti in the gallbladder, and reviews papers on female genital schistosomiasis in rural Madagascar, and a volatile sex attractant of tsetse flies. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode •Female genital schistosomiasis in rural Madagascar (PLoS NTD) •A volatile sex attractant of tsetse flies (Science) •Letters read on TWiP 215 Become a patron of TWiP Case Study for TWiP 215 This case was shared with my by a former student of the Diploma in Tropical Medicine and Hygiene course I coordinate, Prof Eyal Leshem, who is the Director  of the Institute for Travel and Tropical Medicine at the Sheba Medical Center in Tel Aviv and Clinical Associate Professor at the School of Medicine at Tel Aviv University, Israel. This case is of a 24 year old male who presented to the emergency room at the end of February with a 4 day history of fever, starting three weeks after he returned from a long trip. He reports traveling in India during October of the past year. From November to early January, he stayed in Papua New Guinea, from where he traveled to Thailand, returning to Israel in early February. On admission he reports a daily fever up to 40 degrees C, which I think is 104 Fahrenheit. He also mentions an itchy rash and dry cough. We learn a bit more about this patient. In Thailand, he received a five-day course of doxycycline due to a febrile illness, which resolved after treatment. During his stay in Papua New Guinea he hiked in the jungle, was bitten by multiple insects and also report finding leeches attached to his lower legs. One insect bite on his hip took a while to heal. He also reports swimming in multiple rivers. While travelling, he did not have unprotected sexual encounters but he admits to eating street food and home made food regularly. He received pre-travel vaccines and when he was in Papua New Guinea took Atovaquone Proguanil prophylaxis daily, discontinuing therapy a week after he flew to Thailand. On physical exam he is alert and oriented, vitals normal, the examination is unremarkable except for three cropped vesicles on his penis, which the patients says are itchy. A healed insect bite on his lower hip is also noted. His white blood count and differential are normal without eosinophilia. His haemoglobin is 13 g/dl, which is borderline normal and his platelet count is lower than normal with a count of 100,000 per microlitre of blood. What is your diagnosis? What test or tests would you like to order to confirm your suspicion. We would like you to be as accurate as you can when identifying the parasite causing this man's symptoms. What are special considerations you need to think about for treatment? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Kay Schaefer joins TWiP to solve the case of the German Male with Hematuria, and discusses Tropical Medicine Excursions, which provides patient-oriented training courses for healthcare professionals who wish to improve their clinical skills in tropical medicine and travelers' health in the endemic regions of Uganda, Tanzania and Ghana. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Kay Schaefer Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join MicrobeTV Discord server TROPMEDEX Letters read on TWiP 214 Become a patron of TWiP Case Study for TWiP 214 Still in Uganda but now in a clinic in Entebbe. A boy, less than age 10, who grows up in very limited conditions, dirt floor home with other siblings presents with recurrent right upper abdominal pain, fevers, and first undergoes blood work that shows eosinophilia. He has an abdominal ultrasound performed which shows what looks like a mobile piece of spaghetti in the gallbladder with dilated ducts. He also has a stool examination performed. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Jessie Stone joins TWiP to solve the case of the Boy With a Swollen Belly, and discusses Soft Power Health, a clinic that she founded in Uganda to provide healthcare for people in need. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Jessie Stone Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode •Soft Power Health •Letters read on TWiP 213 Become a patron of TWiP Case Study for TWiP 213 A 49 y.o. German male is seen with significant gross hematuria. He reports no travel outside Europe but does report that he visited France twice, 7 years before and 1 year before. He reports swimming in the Solenzara River in the southeastern part of the island, near a busy campsite. He might have gone into the Gravona River in western Corsica near Ajaccio, at a turtle park and near a campsite, and at the Tavignano River. The patient also reported swimming in the Restonica River. He reports never swimming in the Cavu River and using GPS data from his smartphone and camera, he reconstructed his bathing sites precisely and this history was confirmed. Exam was unremarkable. Complete blood count was unremarkable and did not show eosinophilia. This complaint triggered cystoscopy and biopsies that were sent for histological analysis. These findings triggered referral to the Tropical Medicine department at LMU Hospital Munich. Now in the next episode we will have a guest to discuss this case as well as tell us a bit about themselves. I am hoping people will tell us what they think this might be but then perhaps do a bit of research and go into a little more detail. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

We have a really important episode for you as we approach World Neglected Tropical Disease (NTD) day on 30th January calling for all to act together and act now.We are going to be talking about female genital schistosomiasis, which affects approximately 56 million girls and women in sub-Saharan Africa. Host, Kim Ozano is joined by co-host Pamela Mbabazi from the United Nations with guests; Rhoda Ndubani, who is a study manager for a female sexual reproductive health screening programme for FGS in Zambia, Christine Masong, who is a PhD student with Liverpool School of Tropical Medicine undertaking research in Cameroon, exploring how culture and the social structures affect illness experiences and treatment pathways of girls and women with FGS, and finally, Dr. Victoria Gamba, who is a gynaecologist and advocate for FGS awareness based in Kenya. If you would like to understand more about FGS, here's some resources for you:A call to action for universal health coverage: Why we need to address gender inequities in the neglected tropical diseases community https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067373/Discussion paper the gender dimensions of neglected tropical diseases from the Access and Delivery Partnership in partnership with LSTM https://adphealth.org/upload/resource/2523_ADP_Discussion_Paper_NTDs_211119_web.pdfUseful factsheets on FGS:Japanese: https://adphealth.org/upload/resource/2523_ADP_Discussion_Paper_NTDs_211119_web.pdfEnglish: https://adphealth.org/upload/resource/2658_ADP_NTDs_and_Gender_factsheet_280120.pdfMore about our guests;Dr. Pamela Sabina Mbabazi - Department of Control of Neglected Tropical Diseases (NTDs), WHO headquarters in GenevaPresently, Pamela is working as a medical epidemiologist in the Department of Control of Neglected Tropical Diseases (NTDs), at the WHO headquarters in Geneva, Switzerland. Her current research interests include strengthening monitoring and evaluation for neglected tropical diseases programmes particularly in vulnerable populations with a focus on women and children, notably for female genital schistosomiasis (FGS).She has authored several publications in peer reviewed journals, mainly related to methodologies for tracking public health gains for neglected tropical diseases and the effects of co-morbidities.Dr. Victoria Gamba - Obstetrician and Gynaecologist, Private Practice/Ministry of Health Kenya/University of NairobiPassionate about participatory efforts to reduce and eliminate vaccine preventable illnesses and an advocate of gender equality and promoting sexual and reproductive health rights of women and girls, Victoria is a resident obstetrician and gynaecologist at a private health group and a part time consultant with the Ministry of Health Department of Vector-borne and neglected tropical diseases in collaboration with LVCT-health Kenya.Rhoda Ndubani -Study Manager, Zambart Rhoda is the study manager at Zambart on a study called ‘Zipime Weka Schista', a longitudinal Cohort Study focusing on Integrating Female Sexual Reproductive Health Screening in Zambia focused on one-stop self-sampling for schistosomiasis and other genital infections. The aim of the study is to develop a holistic approach for the community-based diagnosis of female genital schistosomiasis (FGS) through a comprehensive package for sexual and reproductive health screening including human papillomavirus (HPV), sexually transmitted infections (STIs), HIV and Schistosomiasis across endemicity settings (from high to low transmission) in Zambia. The duration of the study is from 2021 to 2025. And they aim to recruit 2500 women in the cohort. The women are screened for FGS and HPV using self-sampling in the household and at the health facility. The women are provided with...

Schistosomiasis affects about a quarter of a million people worldwide, particularly people living in some of the world's poorest countries. In this talk from EA Global: London 2018, Carolyn Henry of the Schistosomiasis Control Initiative talks about SCI's work against the disease, the value of buy-in from the recipients of their aid, and the importance of  mentoring local government officials.This talk was taken from EA Global: London 2018. Click here to watch the talk with the video.

Christianah Oki is a parasitologist and a project officer at One Health and Development Initiative (OHDI), a nonprofit organization in Nigeria that promotes education, advocacy, research, and solutions on correlated issues of human, animal, and environmental health through the integrated One Health approach. She researches and writes informational articles and opportunities on related issues of Conservation, Wildlife, and Climate Change while contributing to the ideation, fundraising, and implementation of relevant conservation projects in the organizationIn this episode, She talks about her research on drug resistance in parasites in particular schistosomiasis that affects humans.If you want to be Vulnerable on the show, send me an audio message either on speak pipe (https://www.speakpipe.com/VulnerableScientistVoicemail ) or anchor (https://anchor.fm/thevulnerablescientist/message).Feel free to reach out too if you want to talk about a certain topic in the science career space or anything as a scientist that might have nothing to with science but affects scientists. The podcast is on social media @TVscientistPod and Website; TheVulnerablescientist.com.You can support the show (https://www.patreon.com/thevulnerablescientist) on Patreon or Paypal sarahnyanchera(at)gmail or Mpesa at (254)0718-896-962 under Sarah Nyakeri. Hosted on Acast. See acast.com/privacy for more information.

Dr. Ana Sikora, Infectious Diseases Fellow at the University of South Florida Division of Infectious Diseases, presents a review of lesser known tropical infectious diseases syndromes. Dr. Sikora begins by discussing the epidemiology of tropical diseases, and then prioritizes the most important ones based upon WHO categorization. Syndromes discussed includes Drucunculiasis, lymphatic filariasis, Onchocerciasis, soil transmitted helminths, and Schistosomiasis. Lastly, the process by which international organizations such as the WHO coordinate efforts to control or eradicate these syndromes is briefly discussed.

Some diseases are spread almost exclusively by touch or through the skin or mucus membranes. These include Ebola, several parasitic diseases such as hookworm, strongyloides and scabies and some bacterial and fungal infections. Other diseases like COVID-19 and influenza are mainly transmitted via other routes but use touch as a secondary method of spread. This has implications for controlling these diseases, including the role of isolation and sanitation.A lecture by Chris WhittyThe transcript and downloadable versions of the lecture are available from the Gresham College website:https://www.gresham.ac.uk/lectures-and-events/touch-infectionsGresham College has been giving free public lectures since 1597. This tradition continues today with all of our five or so public lectures a week being made available for free download from our website. There are currently over 2,000 lectures free to access or download from the website.Website: http://www.gresham.ac.ukTwitter: http://twitter.com/GreshamCollegeFacebook: https://www.facebook.com/greshamcollegeInstagram: http://www.instagram.com/greshamcollege

Sara from the Febrile Podcast joins the TWiP team at The Incubator to solve the case of the Man With an Egg Laden Colonic Mass, and Daniel presents a new puzzle for us to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Sara Deng Click arrow to play Download TWiP #201 (72 MB .mp3, 60 minutes) Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Febrile podcast Hero: Eloise Blaine Cramm Support MicrobeTV at Parasites Without Borders Letters read on TWiP 202 Become a patron of TWiP Case Study for TWiP 202 Man 60 yo shopkeeper in Rohingya Camp displaced Myanmar natives. 3 months getting up at night, urinating, thirsty, losing weight. Develops rash on elbows, abdomen, very itchy. Rest of family has rash as well. Starts headache, fever, cough, trouble breathing, seeks medical care. O2 sat is in 80s. Past med/surg healthy individual, heavy smoker, HIV negative. Living in dwelling with tin roofs, dirt floors, many people crowded. Elevated WBC count; elevated glucose. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Peter Hotez talks about the global impact and historical context of neglected tropical diseases. He also highlights important developments in mass drug administration and vaccine research and shares why he chose to publish the third edition of Forgotten People, Forgotten Diseases during the COVID-19 pandemic. Ashley's Biggest Takeaways Neglected Tropical Diseases (NTDs) are chronic and debilitating conditions that disproportionately impact people in low- and middle-income countries (LMICs).  Many of these diseases are parasitic, such as hookworm infection, schistosomiasis and chagas disease; however, in recent years, several non-parasitic infections caused by bacteria, fungi and viruses, as well as a few conditions that are not infections, including snake bite and scabies (an ectoparasitic infestation), have been added to the original NTD framework (established in the early 2000s).  What do most NTDs have in common? High prevalence. High mortality; low morbidity. Disabling. Interfere with people's ability to work productively.  Impact child development and/or the health of girls and women. Occur in a setting of poverty and actually cause poverty because of chronic and debilitating effects. Hotez and his colleagues recognized that there is a uniqueness to the NTDs ecosystem, and they began putting together a package of medicines that could be given on a yearly or twice per year basis, using a strategy called Mass Drug Administration (MDA). This involved the identification of medicines that were being used on an annual basis in vertical control programs and combining those medications in a package of interventions that costs about $0.50 per person per year. “Throw in an extra 50 cents per person and we could double or triple the impact of public health interventions,” he explained.   Emerging diseases, such as SARS-CoV-2, capture the attention of the public for obvious reasons. They pose an imminent threat to mankind. NTDs are not emerging infections, but they are ancient afflictions that have plagued humankind for centuries and, as a consequence, have had a huge impact on ancient and modern history. One of the reasons we have mainland China and Taiwan today may have been, in part, due to a parasitic infection, Schistosomiasis. Hotez and colleagues at the Texas Children's Center for Vaccine Development have developed a COVID-19 vaccine, based on simple technology, similar to what is used for the Hepatitis B vaccine. They hope to release the vaccine for emergency use in resource poor countries like India and Indonesia.  When asked about the timing of the publication of his book, the third edition of Forgotten People, Forgotten Diseases, Hotez acknowledged the difficulty of helping countries understand that NTDs have not gone away. COVID-19 is superimposed on top of them, and the pandemic has done a lot of damage in terms of NTD control. Although social disruption has interfered with the ability to deliver mass treatments, Hotez said that it has been gratifying to see that the USAID and their contractors have responded by putting out guidelines about how to deliver mass treatments with safe social distancing. “As a global society, we have to figure out how to walk and chew gum at the same time,” he said. “We've got to take care of COVID, but we really must not lose the momentum we've had for NTDs because the prevalence is starting to decline and we're really starting to make an impact.”

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS Path) Helminth modulation of macrophage immunometabolism (Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

This episode covers bladder cancer.Written notes can be found at https://zerotofinals.com/surgery/urology/bladdercancer/ or in the urology section of the Zero to Finals surgery book.The audio in the episode was expertly edited by Harry Watchman.

Claim free CME just for enjoying this episode! Disclosures: None Jump to: Patient summary - Case media - Case teaching - References CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Patient Summary- Syncope and Pulmonary Hypertension A Somali woman in her mid-30s with no significant past medical history presented with shortness of breath and exertional syncope. EKG revealed evidence of RV strain. CTA-PE protocol did not show PE. However, there was RV dilation and subsequent echocardiogram demonstrated normal LV, but moderately reduced RV function with evidence of RV pressure and volume overload. RVSP was estimated to be 188 mmHg! Case Media ABCDEFGHClick to Enlarge A. CXR, B. ECG, C. PA measurements: Main PA measures 2.4 cm, right PA measures 2.3 cm, left PA measures 1.9 cm, D. Tricuspid valve Doppler, E. RA tracing, F. RV tracing, G. PA tracing, H. Wedge tracing CTA PE: No PE, markedly dilated pulmonary trunk at 4.7 cm. Right main pulmonary artery measures 3.1 cm. TTE: Parasternal long axis: Moderate right ventricular dilation compressing left ventricle. Global right ventricular function is moderately reduced. TTE: Parasternal long axis- RV view: Right ventricular dilation with mild pulmonary regurgitation TTE: Mild pulmonary regurgitation with dilation of main PA TTE: Paradoxical septal motion consistent with right ventricular pressure and volume overload. TTE: Apical 4 chamberParadoxical septal motion consistent with right ventricular pressure and volume overload. Moderate right ventricular dilation.Global right ventricular function is moderately reduced.Severe right atrial enlargement. Paradoxical septal motion consistent with right ventricular pressure and volume overload.Moderate right ventricular dilation.Global right ventricular function is moderately reduced.Severe right atrial enlargement.Moderate to severe tricuspid regurgitation. TTE: Positive bubble study Episode Teaching Pearls Pulmonary hypertension (PH) can generally be categorized as pre-, post-, or combined pre- and post-capillary PH. Isolated pre-capillary pulmonary hypertension is characterized by: mean pulmonary artery pressure (mPAP) ≥ 20 mmHg, a pulmonary capillary wedge pressure (PCWP) ≤ 15 mmHg, and a pulmonary vascular resistance (PVR) ≥ 3 Woods units (WU). Pulmonary arterial hypertension (PAH) (WHO Group 1) falls under pre-capillary pulmonary hypertension.Schistosomiasis is the most common cause of PAH (WHO Group I) worldwide. Approximately 7% of patient with hepatosplenic schistosomiasis have PAH. Some studies suggest that treatment of with praziquantel reverses vascular remodeling; however, there is point of no return, beyond which, anthelmintic therapies are ineffective to prevent progression.Exertional syncope and pericardial effusion are both risk factors for higher mortality in PAH.Women with severe PAH have extremely high risk of maternal morbidity and mortality. Endothelin receptor antagonists are contraindicated in pregnancy due to teratogenicity. Therefore, a pregnancy test must be obtained monthly while on this therapy.Patients with a lower socioeconomic status, based on median household income, have more advanced PAH at the time of diagnosis. Notes 1. How do you approach syncope? Syncope is a sudden transient loss of consciousness associated with absence of postural tone followed by complete and usually rapid recovery. There should be not be clinical evidence of “non-syncope” conditions including seizures, hypoglycemia, drug or alcohol intoxication, concussion due to head trauma and so forth. One approach to determining the etiology of the syncope is to consider 4 major categories: orthostatic, reflex-mediated, cardiac-obstructive,

The TWiPers solve the case of the Teenager in Malawi with Red Urine, then Audun joins to present our clinical case for this episode. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Audun Lier Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Hero: George B. Craig Letters read on TWiP 192 Become a patron of TWiP Case Study for TWiP 192 Older gentlemen with chills, muscle aches, headaches, shortness of breath, family members same symptoms. Hypertension, diabetes. From rural Ecuador, worked in timber industry, worked on farm. No pets. COVID positive. Treated with steroids, ab. Got worse over next two weeks. Developed bloodstream infection and pneumonia. Saw serpiginous trail on diagnostic agar plate of sputum sample. Started on treatment and recovered. No eosinophils on admission, later developed eosinophilia.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

All it takes is a snail, a worm and some freshwater to become infected. Once you are, the disease could persist for decades -- and prove fatal. The culprits come as a pair: freshwater snails harboring parasitic worms.  People cannot do their wilderness travel without knowing about this very prevalent disease. This podcast will tell you what you need to know. 

Chanda Macias, MBA, Ph.D., is the Owner and General Manager of the National Holistic Healing Center Medical Marijuana Dispensary (NHHC) in Washington D.C. NHHC is a patient advocated company dedicated to providing individuals with debilitating medical conditions, and specific illnesses with alternative allopathic medicine. NHHC provides patient education and support, medical marijuana, and medical marijuana-infused products to qualifying patients or designated caregivers in compliance with the DC Department of Health. Dr. Macias earned her Ph.D. from Howard University in 2001 with a concentration in Cell Biology. She was extensively trained at the Howard University Cancer Center studying, breast cancer and evolved her studies to focus developing a model to understand how prostate cancer metastasizes to bone (Macias et al., 2002). She was recruited directly from graduate school to a Fortune 500 Company, Colgate Palmolive Company, to research oral diseases and possible treatment options. Contributing to the launch of several billion-dollar brands including Total® toothpaste and Simply White®, Dr. Macias innovation resulted in three (3) U.S. Patents, and eleven (11) Global Patients (World Intellectual Property Organization). Due to her love of the District of Columbia and metropolitan area, Dr. Macias returned and engaged her passion to innovate through evaluating patients at the U.S. Patent and Trademark Office. Assigned to the Cancer Immunology Art Unit, Dr. Macias examined innovations from a myriad of inventors including Fortune 500 pharmaceutical companies and pro se inventors from academic institutions. Dr. Macias derived from an interesting skill set, the ability to innovate in conjunction with the ability to critique innovations.In acknowledgment of Dr. Macias accomplishments, Dr. Winston Anderson of Howard University, the recipient of President’s Obama Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring (2011), employed her to serve as a Program Site Manager in Addis Ababa, Ethiopia. The National Institutes of Health, Minority Health International Research Training (MHIRT) program sponsored the research activities that investigated infectious diseases including Malaria and Schistosomiasis. Dr. Macias trained six (6) cohorts of advanced undergraduates, master, and doctoral students, and medical students, which resulted in five (5) health-related publications, and five (5) journal articles in the review.During Dr. Macias’ tenure in Ethiopia, she encountered unbelievable realities with the healthcare challenges for the country. The population did not have access to generic antibiotics, which could have saved numerous lives. Instead, she witnessed as the communities perish because of healthcare disparities. It became Dr. Macias mission to be a transformer of change, through further education and experience.Dr. Macias was accepted into the third (3rd) top program for Supply Chain Management MBA program in the U.S. and matriculated at Rutgers University. At Rutgers University, Dr. Macias was trained extensively on supply chain management, which is defined by APICS as, “the movement and storage of raw materials, work-in-process inventory, and finished goods from point of origin to point of consumption. It is the design, planning, execution, control, and monitoring of supply chain activities with the objective of creating net value, building a competitive infrastructure, leveraging worldwide logistics, synchronizing supply with demand and measuring performance globally.”Dr. Macias has the scientific insight to assist with dosages, and medical marijuana strain alignment according to specific ailments. Dr. Macias genuinely wants to assist patients with their healthcare needs, and she is qualified and has the passion to do so.

It's a stomach-churning hypothesis based on previous research: The kinds of worms that affect hundreds of millions of people, mostly in the tropics, may be mitigating the most severe effects of COVID-19. Listen to DW's science podcast for a different angle on the coronavirus — five minutes every day from Germany.

Schistosomiasis where we're going we don't need dams! On this episode of Viral Load the guys wade into the world of Neglected Tropical Disease. How is it that there is a disease that affects almost 1 billion people and most of the world's never heard if it? Tune in this week to find out.

It’s back to your regularly scheduled programming this week with an episode on schistosomiasis (aka bilharzia), that scourge both ancient and modern. We kick off the episode by walking you through the amazingly complex life cycle of these blood flukes and the myriad of symptoms they and their eggs can cause, including a “check out the reproductive output on this one!” moment.  We then trace its early appearances in mummies (of course) and ancient writings, following that up with an overview of how imperialism drove the field of tropical medicine in its early days. To wrap up this wormy episode, we discuss the current, staggering numbers on schisto around the globe.

Hallo Weltretter Es ist mal wieder Mittwoch und eine neue Folge des Weltretter Podcasts wurde gerade veröffentlicht! In unserer neuen Ausgabe unterhält sich Ferdinand mit Jenifer Gabel von der Deutschen Lepra- und Tuberkulosehilfe (DAHW). Die beiden sprechen über die weitverbreitete Tropenkrankheit Schistosomiasis, oder auch Bilharziose. Eines der größten Infektionsgebiete dafür ist das bereits aus unserer […]

The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice. Hosts: Vincent Racaniello, Dand Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Progress towards global eradication of dracunculiasis (MMWR) Rotifer compound that paralyzes schistosome cercariae (PLoS Biol) Image credit Letters read on TWiP 177 Become a patron of TWiP. Case Study for TWiP 177 49 yo man sent to Daniel for ID consultation. Reports in August visited Hawaii with family, then flies to CA. Family event there. Take him to Pakistani restaurant. One day later has gastrointestinal issues, nausea, diarrhea. Goes to urgent care, send stool for O&P. Look at stool, shows chilomastix mesnili. No medicines, will be ok. Over this period of 1 week he loses 15 pounds. Gains 5 back. End of October feels fine, no bloating or diarrhea. No symptoms but goes to gastroenterologist. Stool test returns with D. fragilis; and chilomastix mesnili. Now sees Daniel. Not on any meds. No allergies, no toxic habits, athletic. No illness in family. Normal exam. He ate salads in Hawaii. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Rhianna works at Imperial College London, raising funds for research within Medicine and Sciences. She also conducts research into Neglected Tropical Diseases, such as Schistosomiasis. This study examines ecological theory and sustainable intervention methods, using the Senegal River in Uganda as a lens. You can reach her via LinkedIn; https://www.linkedin.com/in/rhianna-patricia-williams/ For Inquisitive Minds is a fortnightly podcast showcasing post graduate work in all areas. The podcast seeks to identify ground breaking research and bring it to the masses. Visit patreon.com/forinquisitiveminds to learn more about our work! --- Support this podcast: https://anchor.fm/fim/support

Schistosoma, die Pärchenegel mit der immunologischen Tarnkappe, leben in Schnecken als Zwischenwirte und werden durch Kontakt mit Süßwasser auf den Menschen übertragen. Till Koch und Stefan Schmiedel diskutieren über die Schistosomiasis (Bilharziose), die durch die verschiedenen Schistosoma-Arten verursachten Wurmerkrankungen. Dr. Stefan Schmiedel ist Oberarzt und Infektiologe am UKE in Hamburg.

According to the World Health Organization (WHO), Neglected tropical diseases (NTDs)– a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries – affect more than one billion people and cost developing economies billions of dollars every year. Populations living in poverty, without adequate sanitation and in close contact with infectious vectors […] The post Neglected Tropical Diseases: Chagas disease and schistosomiasis appeared first on Outbreak News Today.

According to the World Health Organization (WHO), Neglected tropical diseases (NTDs)– a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries – affect more than one billion people and cost developing economies billions of dollars every year. Populations living in poverty, without adequate sanitation and in close contact with infectious vectors and domestic animals and livestock are those worst affected. On the eve before Christmas eve show this year, I play two interviews about two very important NTDs, both parasitic diseases--Chagas disease and schistosomiasis. Hutchinson Distinguished Professor of Biological Sciences at Loyola University New Orleans, Patricia Dorn, PhD talks about Chagas disease in this Mar. 2017 interview. In the second half, Parasitology teacher and author of the book, Parasites: Tales of Humanity's Most Unwelcome Guests, Rosemary Drisdelle discusses schistosomiasis in this interview earlier this year.

Schistosomiasis, which is caused by parasitic flatworms, affects nearly 210 million people worldwide, primarily in Africa, Asia, and South America, and is responsible for about 200,000 deaths each year, according to the World Health Organization. A research team from Worcester Polytechnic Institute (WPI) and several international organizations looked at tea infusions made from two species of the wormwood plant in the treatment of the parasitic infection and compared it to the standard care, praziquantel. Joining me to discuss the research is Pamela Weathers, PhD. Dr Weathers is a professor of biology and biotechnology at WPI and a co-author of the study.

Schistosomiasis, which is caused by parasitic flatworms, affects nearly 210 million people worldwide, primarily in Africa, Asia, and South America, and is responsible for about 200,000 deaths each year, according to the World Health Organization. A research team from Worcester Polytechnic Institute (WPI) and several international organizations looked at tea infusions made from two species of […] The post Artemisia tea infusions used in the treatment of Schistosomiasis: A look at the study appeared first on Outbreak News Today.

This week, we're presenting stories about unconventional solutions and things that seemed like a great idea at the time! Part 1: Author Kate Greathead sets off on a cross-country drive to escape her anxiety. Part 2: After years of studying worms, Tracy Chong begins to wonder if they might hold the key to alleviating hunger. Kate Greathead is a 9-time Moth Storytelling Slam champion. Her writing has appeared in The New Yorker, The New York Times, and Vanity Fair, and on NPR’s Moth Radio Hour. She was a subject in the American version of the British Up documentary series. She lives in Brooklyn with her husband, the writer Teddy Wayne. Her first novel, Laura & Emma, was published in March 2018. Tracy Chong found her passion working with invertebrates as a graduate student at the University of Illinois. She studied the development and regeneration of the reproductive system in the planarian, a free-living flatworm. She is currently part of a team at the Morgridge Institute for Research studying parasitic worms that causes the debilitating disease, Schistosomiasis. Aside from worms and science, Tracy is passionate about entrepreneurship and food. Combining her formal training as a scientist, with her culinary interest and hands-on business experience, Tracy’s vision is to provide a sustainable and affordable source of protein to meet the world’s growing global nutritional demands. Learn more about your ad choices. Visit megaphone.fm/adchoices

Shivang joins the TWiP triumvirate to solve the case of the New Yorker With Rash and Pins and Needles, and reveal how agrochemicals increase risk of human schistosomiasis by causing high snail density. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Shivang Shah Become a patron of TWiP. Links for this episode: Even dinosaurs had parasites (Cosmos Mag) Why some people are wormier than others (RSTMH) Angiostrongylus species in badger lungs (thanks, Rachel!) Spread of rat lungworm (Hawaii News Now) Aussie teenager swallowed slug (news.com.au) Agrochemicals increase snail numbers (Nat Comm) Parasite Hero: Émile Brumpt Image credit Letters read on TWiP 149 Case Study for TWiP 149 31 yo man ulcer on let, 4 cm diameter. Raised borders, reddish and hard. Feels well, concerned not resolving. Started as bump, slowly enlarged, ulcerated, 1 month now. Healthy, no prior med, diabetes in mom. Works in field with machete, lives with family, social drinking, smoking. Lives in isolated villages on Northern Panama archepelago, many animals and insects. Homes are raised, slats on floor. No fever, normal bp hr, breathing low teens. Healthy athletic young man, otherwise good health except for ulcer on left leg. Non tender, no pain, base of ulcer red; no purulent material, borders raised but not undermined. Feels hard around edge, no scab. Did dermoscopic exam: erythema, small yellowish teardrops, small white starbursts. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

On today's show, we talk about schistosomiasis. Health authorities say more than 200 million people are infected worldwide and in terms of impact, this disease is second only to malaria as the most devastating parasitic disease. My guest, Parasitology teacher and author of the book, Parasites: Tales of Humanity's Most Unwelcome Guests, Rosemary Drisdelle joined me to discuss the complex life cycle and disease of this neglected tropical disease, among other important information.

On today’s show, we talk about schistosomiasis. Health authorities say more than 200 million people are infected worldwide and in terms of impact, this disease is second only to malaria as the most devastating parasitic disease. My guest, Parasitology teacher and author of the book, Parasites: Tales of Humanity’s Most Unwelcome Guests, Rosemary Drisdelle joined me […] The post Schistosomiasis: In terms of impact, it’s second only to malaria as the most devastating parasitic disease appeared first on Outbreak News Today.

Winka Le Clec'h, Ph.D., Tim Anderson, Ph.D., and Frederic Chevalier research schistosomiasis at Texas Biomed. Schistosomiasis is an important tropical disease caused by schistosome trematodes (a parasitic blood fluke). Those parasites are found in South America and the Caribbean, sub-Saharan Africa, the Middle East, and Southeast Asia. An estimated 200 million people worldwide are infected with schistosomes and 200,000 people die each year. Schistosomiasis is a waterborne disease. Infected freshwater snails release larvae (cercariae) which can infect humans during their water related activities.   Only one drug – praziquantel – is currently available to treat patients but drug resistance starts to emerge. Vaccines have been designed in laboratory but have never conferred decent level of protection to people in the field. Therefore new approaches are needed to identify drug targets, understand drug resistance, predict vaccine efficacy by understanding parasite population diversity and identify potential vaccine candidates. More than 6,000 snails used for research are housed at Texas Biomed. The Texas Biomed schistosomiasis lab has pioneered the use of genetic crosses between schistosomes in the laboratory for identifying the genetic basis of biomedically important parasite traits. Scientists have used this approach, together with exome sequencing, to identify the precise mutations that underlie oxamniquine resistance, and are now applying the same approach to understand praziquantel resistance, host specificity, parasite virulence, and multiple other important biomedical traits. High speed data processing in the Genomics Computing Center make this research possible.

This episode involves a Nature Walk contest, "Who's That Non-Bird: Killer Edition". (We'll save the killer birds for another day.) The contest question is this: which non-birds are responsible for the most human deaths in the world per year? Warren asks the rest of us to guess the top 11. Here's a little foreshadowing: Warren will cite some stats for non-animal causes of death for contrast, and John will contest them furiously. This contest is only one episode, but it's still surprisingly long, or at least it feels that way... If you want to correct any of Warren's statistics, send us an email (maskedman@limitedappeal.net). Theme music courtesy of General Patton vs. The X-Ecutioners and Ipecac Recordings.

The TWiPwalas solve the case of the Woman with a Worm in Her Eye, and discuss the role of nitric oxide in the resistance of rats to Schistosoma japonicum. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Nitric oxide blocks schistosome development (PNAS) Photo credit: Dave the Sheep Shearer Letters read on TWiP 139 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twip. Case Study for TWiP 139 Seen at Columbia Medical Center, a crossover. Woman in 30s returns to US after 2 years in Peace Corp, Cameroon and Gabon. On medical exam 2 years earlier: eosiniphilia noted, no diagnosis reached. Now comes to NYC 2 years later to attend grad school, again eosinophilia noted. Asymptomatic. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

In this special episode of the eLife Podcast, we discuss diseases common in tropical countries including tuberculosis, Zika, malaria and schistosomiasis. Get the references and the transcripts for this programme from the Naked Scientists website

In der vorliegenden Arbeit wurden insgesamt 497 Patienten mit mikroskopisch gesicherten Helminthiasen hinsichtlich epidemiologischer und klinischer Daten sowie auf indirekte Laborparameter (Eosinophilie und Gesamt-IgE-Erhöhung) und die Resultate immundiagnostischer Verfahren untersucht. Hierbei wurden die Ergebnisse von 329 Reiserückkehrern und 168 Migranten mit jeweils 8 Diagnosen (Ankylostomiasis, Askariasis, Fasziolose, Filariose, Schistosomiasis, Trichinose, Trichuriasis, Mischinfektionen) miteinander verglichen. Für die Evaluation der immundiagnostischen Verfahren wurden vorhandene Seren mit 9 Antigenen (Schistosoma mansoni, Onchocerca volvulus, Dirofilaria imitis, Trichinella spiralis, Fasciola hepatica, Toxocara canis, Strongyloides ratti, Ascaris lumbricoides, Ascaris suum) getestet. Vorbestehende Ergebnisse aus der Routinediagnostik wurden mit einbezogen. Als Kontrollen dienten die Seren von 80 gesunden Personen ohne Hinweise auf eine Wurmerkrankung in der Vorgeschichte und ohne einen vorherigen Aufenthalt in den Tropen oder Subtropen. Die epidemiologischen Daten zeigen eine eindeutige Zuordnung von Schistosomiasis und Filariosen auf den afrikanischen Kontinent, während die Geohelminthiasen (Erkrankungen durch Helminthen, deren präadulte Stadien sich im Erdboden entwickeln und die eine reise- bzw. migationsmedizinisch wichtige Bedeutung haben) von den Reiserückkehrern vorwiegend in Asien, vorzugsweise in Südostasien, akquiriert wurden. Die Migranten stammten hauptanteilig aus Afrika, es waren dennoch alle wesentlichen tropischen und subtropischen Gebiete vertreten. Die Auswertung der klinischen Symptomatik zeigte ein klares Erscheinungsbild der Filariosen mit Hauterscheinungen und Juckreiz sowie die überdurchschnittlich häufige Angabe von Harnwegsbeschwerden bei Infektionen mit Schistosoma haematobium. Bei allen Geohelminthosen und Infektionen mit Schistosoma mansoni herrschte bei den Reiserückkehrern eine gastrointestinale Symptomatik vor, während die Migranten insgesamt mehr unspezifische Beschwerden aufwiesen. Circa ein Drittel der Patienten war asymptomatisch. Die Sensitivität der Eosinophilie als indirekter Parameter lag in dieser Arbeit für Wurmerkrankungen im Allgemeinen bei 45%, variierte aber von Diagnose zu Diagnose erheblich, wobei kein signifikanter Unterschied zwischen Reiserückkehrern und Migranten zu finden war. Eine Hypereosinophilie fand sich überdurchschnittlich häufig bei Migranten mit Filariose und bei Reiserückkehrern mit Strongyloidiasis; die Patienten mit Askariasis und Trichuriasis zeigten dagegen kaum Abweichungen von der Kontrollgruppe. Eine Gesamt-IgE-Erhöhung fand sich insgesamt bei 43% der Patienten, wobei es einen signifikanten Unterschied zwischen Reiserückkehrern (25%) und Migranten (75%) gab. Besonders hohe IgE-Serumspiegel konnten bei Migranten mit Schistosomiasis, Strongyloidiasis und Ankylostomiasis gefunden werden. Davon abweichend waren allerdings die Resultate von Reiserückkehrern mit Mischinfektionen. Bei diesen Patienten konnte eine unerwartet häufige Gesamt-IgE-Erhöhung verzeichnet werden (75%). Die serologischen Untersuchungen zeigten zumeist eine gute Sensitivität, aber erhebliche Kreuzreaktionen mit verwandten und nicht verwandten Wurmarten, sodass eine Differenzierung nur für die Schistosomiasis und die Filariosen valide gewährleistet ist. Der im Rahmen dieser Arbeit entwickelte Ascaris suum-ELISA, ergab eine Sensitivität von 60% und eine Spezifität von 90% und hat in der Routinediagnostik eine gewisse Berechtigung, da der Ascaris lumbricoides-ELISA inakzeptable Ergebnisse erbrachte. Zusammengefasst stellt die Eosinophilie einen wichtigen hinweisenden Parameter auf eine Wurminfektion dar, ist aber keine ausreichende Screeningmethode bei Rückkehr aus Endemiegebieten. Die serologischen Untersuchungen ergaben eine sinnvolle diagnostische Ergänzung bei der Schistosomiasis und den Filariosen. Eine Differenzierung der Geohelminthosen ist weiterhin nur durch direkte Nachweismethoden, wie z. B. dem Ei- bzw. Larvennachweis im Stuhl oder in einem Körpergewebe, verlässlich möglich.

In den letzten Jahrzehnten haben sich Reisetätigkeit und Migration zu wichtigen Faktoren für die Ausbreitung von Infektionskrankheiten entwickelt. Allein im Jahr 2011 fanden über 980 Mio. internationale Reisen statt, wobei etwa 50 Mio. Menschen aus industrialisierten Ländern in die Tropen und Subtropen reisten. Ökologische und sozioökonomische Veränderungen, bedingt durch eine wachsende Weltbevölkerung und eine globalisierte Wirtschaft, und der technische Fortschritt beim Transport werden diesen internationalen Personenaustausch und damit die Ausbreitung von Infektionskrankheiten weiter fördern. Um dieser Entwicklung Rechnung zu tragen, wurde die Reisemedizin als eigene Fachrichtung der Medizin mit dem Ziel etabliert, durch international gültige Regelungen reiseassoziierte Infektionskrankheiten zu bekämpfen. Doch vor allem die epidemiologischen Gesundheitsdaten bezüglich der importierten Infektionskrankheiten bei Kindern und Jugendlichen sind limitiert, was insofern ein Problem ist, weil Kinder und Jugendliche bei Reisen häufig von einem anderen Erregerspektrum als Erwachsene betroffen sind und einen im Vergleich zu Erwachsenen unterschiedlichen Krankheitsverlauf bei Infektionen zeigen. Deswegen hat sich diese Dissertation das Ziel gesetzt, die reisemedizinische Beratung von Kindern und Jugendlichen bzw. ihrer Erziehungsberechtigten vor der Reise als auch die diagnostischen Abläufe zum Erkennen der importierten Infektionskrankheit nach der Reise auf eine evidenzbasiertere Grundlage zu stellen. Um evidenzbasierte Empfehlungen zu geben, bedient sich diese Dissertation Methoden der deskriptiven und der analytischen Epidemiologie. Dazu wurden in der Abteilung für Infektions- und Tropenmedizin der Ludwig-Maximilians-Universität München innerhalb des Zeitraums von Januar 1999 bis Dezember 2009 Daten von 890 Reisenden im Alter von unter 20 Jahren, welche aus den Tropen oder Subtropen zurückgekehrt waren, gesammelt und wichtige klinische (z.B. Symptome) und diagnostische (z.B. Laborparameter) Variablen (abhängige Variablen) bezüglich importierter Infektionskrankheiten beschrieben, analysiert und interpretiert. Darauf aufbauend wurde die Auswirkung von Risikofaktoren bzw. protektiven Faktoren (unabhängige Variablen), welche sich in sozio-demographische Daten (z.B. Geschlecht, Alter, Herkunft) und Reisedaten (z.B. Reiseziel, Reisedauer, Reiseart) aufteilen, auf die abhängigen Variablen analysiert. Diese Analyse ergab, dass von allen in dieser Studie untersuchten Variablen Reiseziel und Patientenalter diejenigen Variablen waren, die am stärksten mit dem Risiko korrelierten, an einer für die Tropen und Subtropen typischen oder spezifischen Infektionskrankheit zu erkranken. Bezüglich der Variable Alter zeigte sich, dass Reisende älter als neun Jahre eine ähnliche Verteilung der Krankheitshäufigkeiten wie Erwachsene aufweisen. Mit zunehmendem Alter unternahmen Reisende häufiger Rucksackreisen und infizierten sich öfter mit Mononukleose, was die wachsende Bedeutung der Reise als Unterhaltung und Selbsterfahrung, insbesondere bei Jugendlichen, unterstreicht. Im Gegensatz dazu präsentierten Kinder unter zehn Jahren ein von den Erwachsenen abweichendes Verteilungsmuster der Infektionskrankheiten. So hatten sehr junge Reisende ein erhöhtes Risiko für Durchfall- und Hauterkrankungen während der Reise. Deshalb sollten junge Reisende oder ihre Erziehungsberechtigten vor Reiseantritt über die Präventionsmaßnahmen und mögliche Laientherapie dieser beiden Syndromgruppen aufgeklärt werden bzw. darüber, bei welcher Symptomkonstellation ein Arztbesuch anzuraten ist. Zudem reisten sehr junge Menschen länger und besuchten häufiger Freunde und Familie. Die längere Reisedauer wiederum war verbunden mit einer relativen Zunahme von spezifischen importierten Infektionskrankheiten. Deswegen sollte bei Patienten, die sich länger in tropischen und subtropischen Regionen aufgehalten haben und nach anamnestischen und klinischen Kriterien einer spezifischen Diagnostik und Therapie bedürfen, an diese Erreger gedacht werden. Dagegen kann von einer derartigen spezifischen Diagnostik bei Patienten mit kurzer Reisedauer abgesehen werden, da eine Durchfallsymptomatik bei diesen meist durch akute Durchfallerkrankungen bedingt ist, die nur einer symptomatischen Therapie bedürfen. Aufgrund der begrenzten geografischen Verteilung bestimmter Infektionserreger stellte die Variable Reiseziel einen wichtigen Risikofaktor für das Auftreten von den durch diese Erreger verursachten Erkrankungen dar. Dies verdinglicht noch einmal die Notwendigkeit, Patienten im Beratungsgespräch vor Reiseantritt auf das sie erwartende landesspezifische Erregerspektrum vorzubereiten und die für ebendiese Erreger geeigneten Präventionsmaßnahmen durchzuführen. Dies bedeutet, dass bei Reisen nach Lateinamerika der Schwerpunkt auf Aufklärung über und Prävention von Hautkrankheiten im Allgemeinen und Larva migrans cutanea im Speziellen gelegt werden sollte. Dagegen sollte bei Afrikareisenden auf Schistosomiasis und bei Asienreisenden auf Campylobacteriose und Dengue-Fieber hingewiesen werden. Das höchste relative Risiko, überhaupt zu erkranken, trugen junge Reisende, die sich in Zentral-, West- und Ostafrika aufhielten, gefolgt von Reisenden in Südamerika und Süd-/ Südostasien. Während bei Kindern und Jugendlichen, die eine andere Herkunft als die deutsche hatten, die Variable Herkunft signifikant mit bestimmten importierten Infektionskrankheiten korrelierte, wurde bei den Reisenden deutscher Herkunft, die als Reiseart Besuch bei Freunden und Verwandten angaben, also mit hoher Wahrscheinlichkeit Kinder von Immigranten aus tropischen und subtropischen Ländern sind, keine derartige Korrelation gefunden. Dies legt nahe, dass die Diagnostik und Therapie bei Reiserückkehrer mit Migrationshintergrund nur dann von der von Menschen ohne Migrationshintergrund abweichen sollte, wenn diese eine eigene Migrationserfahrung haben, nicht aber, wenn sie in Deutschland geboren wurden. Das Spektrum der mit Regelmäßigkeit erfassten Symptome bei der Studienpopulation war relativ schmal. Jeweils über ein Fünftel der Patienten stellte sich mit Diarrhö, Müdigkeit, Fieber und Hauterscheinungen vor und insgesamt kamen nur sieben Symptome bei mehr als 10% der Patienten vor; Durchfallerkrankungen, systemische Fiebererkrankungen und Hauterkrankungen machten über 60% der 823 gestellten Diagnosen aus. Dabei waren Durchfallerkrankungen sowohl bei dem Symptom Durchfall als auch bei dem Symptom Fieber wichtigster Auslöser mit Giardia, Campylobacter, und Salmonella als den am häufigsten identifizierten speziellen Infektionserregern. Da Fieber vor allem bei sehr jungen Menschen nicht vorwiegend durch eine als systemische Fiebererkrankung klassifizierte Krankheit bedingt war, ist es umso wichtiger, nicht von bestimmten Symptomen auf Krankheitsentitäten zu schließen, sondern vor einer speziellen Diagnostik durch eine ausführliche Anamnese und klinische Untersuchung weitere Risikofaktoren zu erfassen, um die Krankheit so besser eingrenzen zu können. Insgesamt ließen sich wenige spezifische ätiologische Diagnosen stellen, so dass nur elf Infektionskrankheiten jeweils bei mehr als 1% der Patienten nachzuweisen waren. Besonders gilt dies für die Patienten mit Diarrhö, bei denen 40% mit einer unspezifischen Gastroenteritis diagnostiziert wurden. Die Symptome Fieber, Müdigkeit und Kopfschmerzen stellten für das Patientenkollektiv offensichtlich eine stärkere Belastung dar als andere Symptome, so dass sie schon nach einer signifikant kürzeren Beschwerdedauer einen Arzt konsultierten. Um die Gültigkeit und Anwendbarkeit der vorausgegangen Empfehlungen einschätzen zu können, sollte man die folgenden Limitationen dieser Studie beachten. Die untersuchte Studienpopulation ist wahrscheinlich nicht repräsentativ für alle Reiserückkehrer nach Deutschland, die die von dieser Studie gestellten Einschlusskriterien erfüllen. Gleiches gilt für das Spektrum der Symptome und Erkrankungen, mit denen sich diese Studienpopulation im AITM vorstellte. Es ist anzunehmen, dass viele leichte und selbstlimitierende Verläufe von importierten Infektionskrankheiten an anderen Institutionen behandelt wurden. Ebenso unterrepräsentiert sind Erkrankungen mit einer kurzen Inkubationszeit oder einer unspezifischen Symptomatik, da die Assoziation mit Reise nicht erfolgt. Zwar ist es möglich, aus den untersuchten Daten und Statistiken über Reiseaktivität das relative Erkrankungsrisiko importierter Infektionskrankheiten abzuschätzen, aber es ist nicht möglich, deren Inzidenz zu berechnen. Durch die Einteilung von Krankheiten in Syndromgruppen wurde versucht, eine Konsistenz und Vergleichbarkeit mit vorausgegangenen Studien herzustellen. Gleichzeitig führt dieses Vorgehen aber auch zu einer artifiziellen Homogenisierung, die zu falschen Schlussfolgerungen für spezifische Krankheiten innerhalb dieser Syndromgruppen führen kann. Entsprechendes gilt für alle in dieser Studie verwendeten Variablen, die, um eine für die statistische Auswertung genügend große Patientenanzahl zu erhalten oder um der Vergleichbarkeit halber Referenzwerte einzuhalten, skaliert werden mussten. Dies ist bei nominalskalierten Variablen (z.B. Geschlecht) problemlos möglich, führt aber bei kardinalskalierten Variablen (z.B. Alter) durch das Setzen bestimmter Grenzwerte (z.B. Altersgruppe 0-4 Jahre) automatisch zu Ungenauigkeiten und Verschleierung von Korrelationen (z.B. zwischen Altersgrupe 3-7 Jahre und einer anderen Variablen). Zudem bedingt der Versuch, die Störfaktoren durch Einschlusskriterien gering zu halten, gleichzeitig, dass Personengruppe, für welche die Ergebnisse anwendbar sind, schrumpft. Die geschilderten Probleme betreffen nicht nur diese Dissertation sondern alle in dieser Studie zitierten Publikationen, die sich mit einem ähnlichen Thema beschäftigt haben. Dies liegt daran, dass einerseits Daten über erkrankte Reiserückkehrer nicht zentral nach einheitlichen Kriterien gesammelt werden, sondern in den unterschiedlichen Institutionen eigenständige Prozeduren zur Datensammlung stattfinden und dass andererseits die Übermittlung dieser Daten an ein zentrales Institut nicht von allen erkrankten Reiserückkehrern erfolgt. Um in der Lage zu sein, standardisierte evidenzbasierte Empfehlungen für die Diagnostik und Therapie zu geben, muss zuerst die Datenakquirierung und Datenanalyse standardisiert werden.

Background: Acute schistosomiasis constitutes a rare but serious condition in individuals experiencing their first prepatent Schistosoma infection. To circumvent costly and time-consuming diagnostics, an early and rapid diagnosis is required. So far, classic diagnostic tools such as parasite microscopy or serology lack considerable sensitivity at this early stage of Schistosoma infection. To validate the use of a blood based real-time polymerase chain reaction (PCR) test for the detection of Schistosoma DNA in patients with acute schistosomiasis who acquired their infection in various endemic regions we conducted a European-wide prospective study in 11 centres specialized in travel medicine and tropical medicine. Methods: Patients with a history of recent travelling to schistosomiasis endemic regions and freshwater contacts, an episode of fever (body temperature >= 38.5 degrees C) and an absolute or relative eosinophil count of >= 700/mu l or 10%, were eligible for participation. PCR testing with DNA extracted from serum was compared with results from serology and microscopy. Results: Of the 38 patients with acute schistosomiasis included into the study, PCR detected Schistosoma DNA in 35 patients at initial presentation (sensitivity 92%). In contrast, sensitivity of serology (enzyme immunoassay and/or immunofluorescence assay) or parasite microscopy was only 70% and 24%, respectively. Conclusion: For the early diagnosis of acute schistosomiasis, real-time PCR for the detection of schistosoma DNA in serum is more sensitive than classic diagnostic tools such as serology or microscopy, irrespective of the region of infection. Generalization of the results to all Schistosoma species may be difficult as in the study presented here only eggs of S. mansoni were detected by microscopy. A minimum amount of two millilitre of serum is required for sufficient diagnostic accuracy.

ATLANTA—Schistosomiasis — also known as bilharzia — could be eliminated from Africa and elsewhere by using two actions together: making simple improvements in water-supply sanitation and hygiene and treating infected children with free praziquantel — recently made available by the manufacturers. At the American Society of Tropical Medicine and Hygiene annual conference Alan Fenwick, Professor of Tropical Parasitology at Imperial College in London, chaired a symposium reviewing the latest evidence about practical ways of achieving success against this parasitic disease. He discussed the conclusions with Peter Goodwin.

PHILADELPHIA—Scientists in the UK and Uganda have now completed a three year study showing that young children are at continued risk of intestinal schistosomiasis — also known as bilharzia — between the ages of 6-months and five years. In fact, these children should be treated routinely with the anthelminthic praziquantel, just as in older children and adults, for it is proven both safe and efficacious. The Schistosomiasis In Mothers and Infants (SIMI) study was conducted by the Liverpool School of Tropical Medicine and the London School of Hygiene & Tropical Medicine working with the Vector Control Division, Ministry of Health, in Uganda and was reported at the American Society of Tropical Medicine and Hygiene annual conference in Philadelphia. Professor Russell Stothard discussed some of the key findings with Peter Goodwin.

Thu, 10 Nov 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13878/ https://edoc.ub.uni-muenchen.de/13878/1/Scharmann_Claas.pdf Scharmann, Claas

Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.

Former U.S. President Jimmy Carter discusses current Carter Center peace and health initiatives around the world.

David Molyneux introduces the Neglected Tropical Diseases Series.

Overview of the Carter Center's effort to control schistosomiasis.

Warm up to the winter BioPOD! Dan Nussey rages about ageing, Richard Milne orates about orchids, Alastair Wilson runs the course on horse stud fees, and Ruth Corrigan gives a research round-up from the Institute of Immunology and Infection Research.

Clean water is something that many of us take for granted, but Mark Booth describes how in many parts of the world dirty water can lead to life-threatening disease and parasitic infections. To talk about the current strategies in place to supply clean water we are joined by the World Heath Organisations Alex McKie, and Colin Humphreys explains how high-energy UV LEDs could help provide clean water in the future. In Kitchen Science, Helen Scales and Dave Ansell bring sweetness and light to a house in Cottenham... Like this podcast? Please help us by supporting the Naked Scientists

Clean water is something that many of us take for granted, but Mark Booth describes how in many parts of the world dirty water can lead to life-threatening disease and parasitic infections. To talk about the current strategies in place to supply clean water we are joined by the World Heath Organisations Alex McKie, and Colin Humphreys explains how high-energy UV LEDs could help provide clean water in the future. In Kitchen Science, Helen Scales and Dave Ansell bring sweetness and light to a house in Cottenham... Like this podcast? Please help us by supporting the Naked Scientists

Ectopic late cutaneous schistosomiasis is usually preceded or accompanied by visceral schistosomiasis infection. Our patient presented the very rare case of late cutaneous schistosomiasis as an isolated skin manifestation. Perigenital lesions occurred 1 year after contact with infested water. Identification of the few eggs remaining in the late lesion among the dense cellular infiltrate was difficult. Electron-microscopic studies clearly demonstrated the characteristic eggshell ultrastructure. Copyright (C) 2000 S. Karger AG, Basel.