Podcasts about The BMJ

For several decades, saturated fat was wrongly blamed for heart disease, while vegetable oils quietly caused a surge in obesity, inflammation, and chronic metabolic disorders Newly appointed FDA commissioner Dr. Marty Makary is now leading efforts to revise outdated dietary guidelines that were built on cherry-picked data from Ancel Keys' Seven Countries Study A 2016 BMJ-published reanalysis found replacing saturated fat with linoleic acid-rich vegetable oils increased cardiovascular deaths, despite lowering cholesterol Investigative journalist Dr. Maryanne Demasi faced vicious backlash after exposing the flawed science behind saturated fat demonization in her documentary “Heart of the Matter” Industrial seed oils like canola and soybean are now linked to mitochondrial damage, inflammation, and chronic illness — while saturated fat is finally being recognized as metabolically supportive

This week, we're unpacking the big stories shaping food, health and how we live. We start with a major BMJ study showing that eating chips three times a week raises type 2 diabetes risk by 20% but baked or boiled potatoes don't carry the same danger. We'll share why the way you cook them matters, plus the genuine health benefits of potatoes when they're not fried. Next, a Guardian feature on “otroverts” — people who don't feel at home in groups but aren't introverts either. Psychiatrist Dr Rami Kaminski explains why this isn't a deficit, how it can be a strength, and what it tells us about solitude, loneliness and connection. And from the Times, the science of the “holiday brain-boost.” We explore how holidays can slow cognitive ageing, why even short breaks matter, and the habits from naps to mindfulness and movement that help the benefits last for weeks after you're home. Plus, the trends: Australia's world-first ban on social media for under 16s, and the UK government's plan to restrict energy drink sales to teenagers. Alongside all that, Ella shares her first weekend in the new house, picking homegrown fruit and veg and welcoming two new puppies, plus a listener story that reveals just how many ultra processed additives can be hiding in a single mini cupcake. Catch Rhi discussing UPFs and The Unprocessed Plate at Waterstones - London Gower Street and Chroleywood Library Learn more about your ad choices. Visit podcastchoices.com/adchoices

In today's episode: Rethinking how we measure the harm caused by the  arms industry The life long, and multigenerational, impact of starvation in Gaza What is the appropriate focus on prevention in general practice?   The BMJ's international editor, Jocalyn Clark talks about a new series we've just published - examining the arms industry as a commercial determinant of health. Jocalyn also speaks to Mark Bellis, from Liverpool John Moores university about why he thinks it's time we take the impact of the arms industry on health seriously. The blockade on food reaching Gaza is in place again, risking more starvation. Elizabeth Mahase, clinical reporter for the BMJ, has been finding out about the acute, chronic, and generational impact on the palestinian population. She speaks to Jonathan Wells, professor of anthropology and paediatric nutrition at University College London, and Tessa Roseboom, professor of early development and health at the University of Amsterdam, Marie McGrath former head of the Emergency Nutrition Network, and Chris McIntosh, humanitarian response advisor for the charity, Oxfam. Finally, an analysis we published earlier this year made the case that "tsunami" of preventative care is destabilised the work of GPs. Helen Macdonald was at the Preventing Overdiagnosis conference and spoke to some of the authors - Minna Johansson, associate professor at University of Gothenberg, Stephen Martin, professor at UMass Chan Medical School, and Iona Heath, retired GP and former president of the RCGP.   Reading list Arms industry as a commercial determinant of health Starvation is a lifelong sentence: Gaza's civilians must be protected in accordance with international humanitarian law Sacrificing patient care for prevention: distortion of the role of general practice  

Oscar Bergholm på P3 Nyheter förklarar morgonens stora nyheter, alltid tillsammans med programledarna för Morgonpasset i P3: Branne Pavlovic och Caisa Ederyd. Lyssna på alla avsnitt i Sveriges Radio Play. Forskare varnar kvinnor för att lägga pengar på onödiga tester och behandlingar som påstås hjälpa inför eller under klimakteriet. Flera tester saknar bevisad effekt och kan vara missvisande, enligt experter i en artikel från tidskriften BMJ. Även en läkare från Svensk förening för obstetrik och gynekologi menar att det är ett oseriöst att tjäna pengar på kvinnors oro. Men apoteken har svarat på kritiken och menar att testen funkar men att resultaten kan variera beroende på när man testar sig.

Severity of common cold symptoms fell 41% in the fittest and 31% in the most active.https://bjsm.bmj.com/content/45/12/987.abstractFlu shots in children: 5× higher risk of noninfluenza respiratory infections (incl. coronaviruses).https://pubmed.ncbi.nlm.nih.gov/22423139/Glyphosate damages gut health.https://www.mdpi.com/1099-4300/15/4/1416Adults sleeping ≤6 h/night were ~4× more likely to develop a cold after rhinovirus exposure; similar with ≤7 h + low sleep efficiency.https://pmc.ncbi.nlm.nih.gov/articles/PMC4531403/Vitamin D deficiency was common in COVID patients—41.9% overall, 80% in severe cases.https://pubmed.ncbi.nlm.nih.gov/33048028/Sea lion study:https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2020.602565/fullNFL player's story:https://bleacherreport.com/articles/1859740-random-things-most-nfl-fans-never-knew-football-players-almost-never-get-sickCowling 2012: Flu shots in children increased risk of noninfluenza infections 5×.https://pubmed.ncbi.nlm.nih.gov/22423139/Wolff study: Vaccinated servicemen had higher odds of coronavirus (+36%), metapneumovirus (+51%), and other noninfluenza viruses (+15%).https://www.sciencedirect.com/science/article/pii/S0264410X19313647Vaccinated kids ≤4 yrs: 4.8× higher hazard of noninfluenza infection (CI 2.88–7.99). Ages 5–17: 1.61× higher hazard (CI 0.98–2.66).https://pubmed.ncbi.nlm.nih.gov/29525279/Chris Kresser (2021): Vitamin D deficiency raised SARS-CoV-2 infection risk by 80%. Deficient patients had 1.77× higher infection risk, 2.57× more severe, 2.35× higher mortality.https://vimeo.com/530879066/e9b314a0beTom Jefferson review of 259 BMJ studies: Flu vaccines had little effect on outcomes like absences, days lost, illness, or death.https://pmc.ncbi.nlm.nih.gov/articles/PMC1626345/Pesticide research (http://ndl.ethernet.edu.et/bitstream/123456789/54884/1/Jonathan%20J.%20Li_2008.pdf#page=399):• Women with reproductive cancers had 4–6× higher pesticide levels (8.7–10.9 mg/L vs 1.9 mg/L).• Living ≤1 mile from a golf course → 126% higher Parkinson's risk; risk drops 13% per mile after 3 mi.• Shared water with golf course → nearly 2× PD risk.• Vulnerable groundwater regions → 82% higher PD risk.“These chemicals can be carcinogenic, mutagenic, teratogenic, and estrogenic (disrupting hormones).”If you need other studies, ask AI or email shortlifeadvice@gmail.com

In this pod Consultant Rheumatologist, Dr Judith Jade, chats with Dr Fergus To, Rheumatologist from British Columbia, about the case of a woman who presented with subacute muscle weakness. They discuss how to approach these types of  cases systemically with some handy tips along the way. Listen in and see if you can work out what the diagnosis is!References:1. Blazing M, et al. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. Lancet. 2022;400(10355):832–452. Kim EJ, Wierzbicki AS. Investigating raised creatine kinase. BMJ. 2021;373:1–5.3. Sharf K, Do T, Ghetie D, Choi D, Chahin N. Benefits of Early vs Late Initiation of IVIG in the Treatment of Anti‐HMGCR Immune‐Mediated Necrotizing Myopathy. Arthritis Care Res (Hoboken) 2024;76:1584–92. https://doi.org/10.1002/acr.25406.4. Allenbach et al, 224th ENMC International Workshop, Neuromuscular Disorders, Volume 28, Issue 1, 87 - 99Thanks for listening to Talking Rheumatology! Join the conversation on X using #TalkingRheum or tweet us @RheumatologyUK.BSR is the UK's leading specialist medical society for rheumatology and MSK health professionals. To discover how we can support you in delivering the best care for your patients, visit our website.

Want more content or to send us a message? Find us on LinkedIn https://www.linkedin.com/company/104953561. Dr Jessica Morley is a leading expert in digital health ethics, data governance, and artificial intelligence policy. Currently a Postdoctoral Researcher at Yale University's Digital Ethics Center, she previously served as Director of Policy at the Bennett Institute for Applied Data Science at the University of Oxford. Jess has also worked at the heart of digital transformation in the NHS, advising government departments on the safe, effective, and ethical implementation of AI technologies.With a background that spans philosophy, health informatics, and public policy, her work focuses on ensuring that AI in healthcare serves the public good—preserving trust, promoting equity, and reinforcing system-level values. She is widely published on ethical frameworks for AI and is a passionate advocate for more accountable and transparent digital health systems. An ideal person to discuss the potential and the pitfalls of AI in the NHS.Can AI really live up to the hype in healthcare? What safeguards are needed — and where do humans still matter most?In this fascinating and enlightening discussion, we explore the promises and pitfalls of artificial intelligence in healthcare with one of the world's leading thinkers on the topic.We continue the theme with our micro-discussion, when we look at the paper Perspectives of Health Care Professionals on the Use of AI to Support Clinical Decision-Making in the Management of Multiple Long-Term Conditions https://pubmed.ncbi.nlm.nih.gov/40613609/. This paper aims to explore the perspectives of primary care Healthcare Professionals on managing Long Term Conditions supported by AI. Links mentioned in the episode:The Briefing Room: How far could artificial intelligence transform medicines? https://www.bbc.co.uk/programmes/m0021bdlCan a digital NHS BE equitable - The BMJ: https://www.bmj.com/content/389/bmj.r1317As with all of our guests, Jess shares with us her Memory Evoking Medicine, a career anthem and book that has influenced her career or life. An apt and personal choice when discussing the dehumanising world of AI.You can listen to the Aural Apothecary playlist here; https://open.spotify.com/playlist/3OsWj4w8sxsvuwR9zMXgn5?si=tiHXrQI7QsGtSQwPyz1KBg You can view the Aural Apothecary Library here;  https://litalist.com/shelf/view-bookcase?publicId=KN6E3OOur website is https://www.theauralapothecary.com/ and you can find us on LinkedIn https://www.linkedin.com/company/104953561. To get in touch follow us on LinkedIn, Bluesky and X @auralapothecary or email us at auralapothecarypod@gmail.com. Don't forget to rate us and comment wherever you have got this podcast from.From Prescription to Ocean — A TEDx Talk by Jamie HayesWe're incredibly proud to share that Aural Apothecary co-host Jamie Hayes has taken to the TEDx stage with a thought-provoking talk:  Prescription to Ocean: The Hidden Impact of Medicineshttps://lnkd.in/eRwqhRuvJamie explores a fascinating and urgent question: What happens to our medicines once they leave the prescription pad — and how do they impact the world beyond the patient? It's a journey that connects healthcare, the environment, and our shared responsibility for the future. You'll never think about prescribing (or taking) medicines in quite the same way again.Please take a few minutes to watch, reflect, and share — this is a conversation worth having.

Un nouvel épisode du Pharmascope est disponible! Dans ce 162e épisode, Nicolas et Isabelle discutent d'études publiées récemment. Au menu : hypertension résistante, gastro-entérite, perte de poids… Avec des mentions spéciales pour la transplantation fécale… et les patates! Les objectifs pour cet épisode sont les suivants: Discuter des avantages et désavantages de l'amiloride dans le traitement de l'hypertension résistante Discuter des avantages et désavantages de l'ondansétron pour la gasto-entérite chez les enfants Discuter des avantages et désavantages de l'ajout de la cagrilintide au sémaglutide pour la perte de poids Ressources pertinentes en lien avec l'épisode Lee CJ, et coll. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial. JAMA. 2025 Jun 17;333(23):2073-2082. Freedman SB, et coll.; Pediatric Emergency Research Canada Innovative Clinical Trials Study Group. Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis. N Engl J Med. 2025 Jul 17;393(3):255-266. Garvey WT, et coll.; REDEFINE 1 Study Group. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025 Aug 14;393(7):635-647. Juul FE, et coll. Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial. Ann Intern Med. 2025 Jul;178(7):940-947. Mousavi SM, et coll. Total and specific potato intake and risk of type 2 diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts. BMJ. 2025 Aug 6;390:e082121.

Drs. Whitney Hartlage (@whithartlage11) and Sam Windham join Dr. Ryan Moenster to discuss updates in the diagnosis and management of community-acquire pneumonia. Hear from our guests on the role of rapid diagnostic tests such as multiplex PCR and urinary antigen tests in the inpatient and outpatient setting, considerations for initiating steroids and withholding macrolides, and when to use short antibiotic durations. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. PMID: 38240492. Odeyemi Y, Tekin A, Schanz C, Schreier D, Cole K, Gajic O, Barreto E. Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193. Butler AM, Nickel KB, Olsen MA, Sahrmann JM, Colvin R, Neuner E, O'Neil CA, Fraser VJ, Durkin MJ. Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults. Clin Infect Dis. 2024 Oct 23:ciae519. doi: 10.1093/cid/ciae519. Epub ahead of print. PMID: 39442057; PMCID: PMC12355227. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. PMID: 36948555; PMCID: PMC10040075 Schober T, Wong K, DeLisle G, et al. Clinical outcomes of rapid respiratory virus testing in emergency departments. JAMA Intern Med. 2024;184(5):528-536. Clark T, Lindsley K, Wigmosta T, et al. Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: results of a systematic review and meta-analysis. J Infect. 2023;86(5):462-475. May L, Robbins EM, Canchola JA, Chugh K, Tran NK. A study to assess the impact of the cobas point-of-care RT-PCR assay (SARS-CoV-2 and Influenza A/B) on patient clinical management in the emergency department of the University of California at David Medical Center. J Clin Virol. 2023:168:105597. Cartuliares MB, Rosenvinge FS, Mogensen CB, Skovsted TA, Andersen SL, Østergaard C, et al. Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med. 2023;20:e1004314. doi: 10.1371/ journal.pmed.1004314. Vaughn VM, Dickson RP, Horowitz JK, Flanders SA. Community-acquired pneumonia: a review. JAMA. 2024;332(15):1282-1295. Davis MR, McCreary EK, Trzebucki AM. Things we do for no reason – ordering Streptococcus pneumoniae urinary antigen in patients with community-acquired pneumonia. Open Forum Infect Dis. 2024;11(3):ofae089. Centers for Disease Control and Prevention. Laboratory Testing for Legionella. Updated June 9, 2025. Accessed July 13, 2025. https://www.cdc.gov/legionella/php/laboratories/index.html. Jain S, Self WH, Wunderink RG. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415-427. Kamat IS, Ramachandram V, Eswaran H, Guffey D, Musher DM. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis. Clin Infect Dis. 2020;70(3):538-542. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single blinded intervention trial. Lancet. 2004;363:600–7. doi: 10.1016/S0140- 6736(04)15591-8. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059–66. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalci- € tonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Datab System Rev. 2017;10(10):CD007498. doi: 10.1002/14651858. cd007498.pub2. Huang DT, Yealy DM, Filbin MR, Brown AM, Chang C-CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower Respiratory tract infection. New Engl J Med. 2018;379:236–49. doi: 10.1056/NEJMoa1802670. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;389(19):1623-1634. doi:10.1056/NEJMoa2215145. Gupta AB, Flanders SA, Petty LA, et al. Inappropriate diagnosis of pneumonia among hospitalized adults. JAMA Intern Med. 2024;184(5):548-556. Jones BE, Chapman AB, Ying J, et al. Diagnostic Discordance, Uncertainty, and Treatment Ambiguity in Community-Acquired Pneumonia: A National Cohort Study of 115 U.S. Veterans Affairs Hospitals. Ann Intern Med. 2024;177(9):1179-1189. doi:10.7326/M23-2505. Hartlage W, Imlay H, Spivak ES. The role of empiric atypical antibiotic coverage in non-severe community-acquired pneumonia. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e214. doi:10.1017/ash.2024.453. Dinh A, Barbier F, Bedos JP, et al. Update of guidelines for management of community acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF). Endorsed by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF); endorsed by the French Intensive Care Society (SRLF), the French Microbiology Society (SFM), the French Radiology Society (SFR), and the French Emergency Society (SFMU). Respir Med and Res. 2025. El Moussaoui R, de Borgie CAJM, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ. 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355. Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia: a randomized, non-inferiority trial. Lancet. 2021;397(10280):1195-1203.

In today's podcast we talk with Eric Wong, geriatrician-researcher from Toronto, and Thiago Silva, geriatrician-researcher from Brazil, about the comprehensive geriatrics assessment.  We spend the first 30 minutes (at least) discussing what, exactly is the comprehensive geriatric assessment, including: What domains of assessment are essential/mandatory components of the comprehensive geriatrics assessment? Who performs it? Is a multidisciplinary team required? Can a geriatrician perform it alone? Can non-geriatricians perform it? Who is the comprehensive geriatrics assessment for? Who is most likely to benefit? Eric Widera suggests not as much benefit for very sick and very healthy older adults, more benefit in the vast middle. Why do the comprehensive geriatrics assessment? What are the interventions that it leads to (we cover this more conceptually, rather than naming all possible interventions) How does the comprehensive geriatrics assessment relate to the 4Ms (or 5 Ms)? How long does it take to conduct a comprehensive geriatrics assessment? What's the evidence (BMJ meta analysis) for the comprehensive geriatrics assessment?  What are the outcomes we hope for from the comprehensive geriatrics assessment?   That final point, about outcomes, bring's us to Eric Wong's study, published in JAGS, which evaluates the cost effectiveness of the comprehensive geriatrics assessment performed by a geriatrician across settings (e.g. acute care, rehab, community clinics). As an aside, as the editor at JAGS who managed this manuscript, I will say that we don't ordinarily publish cost effectiveness studies at JAGS, as the methods are opaque to our clinical audience (e.g. raise your hand if you understand what ‘CGA provided in the combination of acute care and rehab was non-dominated' means). We published this article because its bottom line is of great interest to geriatricians.  In Eric's study, geriatricians performing CGA were more cost effective than usual care in Every. Single. Setting. And of course cost effectiveness is only one small piece of the argument for why we do the comprehensive geriatrics assessment in the first place (no patient in the history of the world has ever asked for a test or treatment because it's cost effective for the health care system). I'll close with a couple of “mic drop” excerpts from Thiago's accompanying editorial: Finally, it is instructive to compare the cost-effectiveness of geriatric services and CGAs with other interventions. A recent analysis of lecanemab for early-stage Alzheimer's disease found that gaining one QALY would cost approximately $287,000 (USD). In contrast, Wong et al. estimated that adding community-based CGA would cost about $1203 (CAD) per quality-adjusted life month (QALM) (equating to roughly $10,105 (USD) per QALY, using $1 USD = $0.7 CAD), making geriatrician-led CGA nearly 30 times more cost-effective. Put simply, for each dollar spent to improve quality of life for a year through CGA, one would need to spend almost $30 to achieve the same benefit with lecanemab.  Ultimately, the question is not whether geriatricians represent a worthwhile investment (they are) but how healthcare systems can ensure that every older adult requiring specialized, comprehensive care can access it. Wong et al.'s modeling study provides a valuable contribution by showing that geriatricians placed in acute and rehabilitation settings offer the most cost-effective deployment given current workforce limitations. Despite some caveats, the overarching message remains clear: geriatric expertise not only enhances care quality but can also align with health-economic objectives, especially in high-acuity environments. However, we cannot allow an inadequate geriatric workforce to become a permanent constraint, forcing painful decisions about which older adults and which settings will miss out on optimal geriatric care. Instead, we should continue to strive to increase the number of geriatricians through robust training programs and payment model reform to ensure that cost-effective care can be provided for this large and growing vulnerable population.  -Alex Smith  

Are ADHD medications just about focus? In this week's NeuroSpicy Hot Topic from The Neurodivergent Experience, hosts Jordan James and Simon Scott break down a brand-new study from the BMJ showing that ADHD medication delivers far more than concentration boosts — with real-world life-saving benefits.From suicidal thoughts to transport accidents, and from substance misuse to criminal risk, we explore:How ADHD meds reduce impulsivity, risky behaviour, and accidentsEmotional regulation: why stimulants help us process feelings without overwhelmReal-life stories: missed trains, re-injuries, bad crowds, and chasing adrenalineWhy taking medication “only on work days” may miss its biggest benefitsThe dangerous oversimplifications of ADHD as just “distracted and hyper”Internal vs external ADHD — and why invisibility creates stereotypesHow methylphenidate helps close “open tabs” in the brain and builds better decision pathwaysThe truth about being “oversensitive” vs “hypersensitive”Whether you've been told ADHD meds are only about productivity, or you're weighing whether daily use is worth it, this conversation blends science, lived experience, and a heavy dose of neurospicy humour to show why these medications can be life-changing far beyond the desk.❤️ Support the ShowIf this episode resonated with you:✅ Follow or Subscribe to The Neurodivergent Experience⭐ Leave a quick review on Apple Podcasts or Spotify

In the era of fast-tracked surgery and same-day discharge, anesthesiologists are looking for strategies to optimize recovery without compromising safety or pain control. A long-standing debate centers around whether low-dose bupivacaine or mepivacaine is the better spinal agent to promote early ambulation after total knee arthroplasty. In this episode of RAPM Focus, RAPM Editor-in-Chief, Brian Sites, MD, explores this debate with Clinton Pillow, MD, following the May 2025 publication of “Mepivacaine versus bupivacaine spinal anesthesia for return of motor function following total knee arthroplasty: a randomized controlled trial.” This episode explores a topic faced by every anesthesiologist that manages joint replacements, especially total knee arthroplasty, has grappled with—what is the ideal spinal anesthetic when time is money and same-day discharge is the goal? Dr. Pillow is an assistant professor in the department of anesthesiology and perioperative medicine at the Medical University of South Carolina. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.

ENCORE: This episode was first published in Sept. 2023.In 1998, a young Norwegian exercise physiologist found that a technique he had used to help Olympic athletes could help heart patients too. But his idea made doctors sweat. One famous cardiologist told him that if he used his technique in human heart attack patients, he "would kill them."Today's show looks at what happened when our researcher, Ulrik Wisløff, defied the experts — and built a career learning how high intensity interval training can help everyone from heart patients and ageing Baby Boomers, and possibly even Alzheimer's patients — but not in the way you might think!Today's guests are Ulrik Wisløff, Dorthe Stensvold and Atefe Tari.Here's a link to a rat on a treadmill photo. And here's a link to a transcript.Here's a list of some of the research mentioned in the podcast:Wisløff U, et al. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.Wisløff U,et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. doi: 10.1161/CIRCULATIONAHA.106.675041. Epub 2007 Jun 4.Rognmo, Ø et al.. Cardiovascular Risk of High- Versus Moderate-Intensity Aerobic Exercise in Coronary Heart Disease Patients Circulation. 2012;126:1436-1440. doi: 10.1161/CIRCULATIONAHA.112.123117Stensvold D, Viken H, Steinshamn S L, Dalen H, Støylen A, Loennechen J P et al. Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 :m3485 Tari AR, Nauman J, Zisko N, Skjellegrind HK, Bosnes I, Bergh S, Stensvold D, Selbæk G, Wisløff U. Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study. Lancet Public Health. 2019 Nov;4(11):e565-e574.Tari AR, Berg HH, Videm V, Bråthen G, White LR, Røsbjørgen RN, Scheffler K, Dalen H, Holte E, Haberg AK, Selbaek G, Lydersen S, Duezel E, Bergh S, Logan-Halvorsrud KR, Sando SB, Wisløff U. Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study. BMJ Open. 2022 Sep 6;12(9):e056964. Hosted on Acast. See acast.com/privacy for more information.

How does genetic testing help doctors treat patients? How accurate are private companies like 23andMe? Does knowing your genetic risk help people lead healthier lives or is it just a waste of time and money? Sophie had a bunch of questions about how genetic testing is used in everyday medical practice and Chris was here to answer!   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at thebodyofevidence@gmail.com.   Editor:    Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Studies evaluating the accuracy of Direct to Consumer genetic testing companies: Ng PC, Murray SS, Levy S, Venter JC. An agenda for personalized medicine. Nature. 2009 Oct 8;461(7265):724-6. doi: 10.1038/461724a. PMID: 19812653. Imai K, Kricka LJ, Fortina P. Concordance study of 3 direct-to-consumer genetic-testing services. Clin Chem. 2011 Mar;57(3):518-21. doi: 10.1373/clinchem.2010.158220.  Studies looking at how knowing the results of genetic testing affect medical treatment and lifestyle factors. Mega JL, et al. Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet. 2015 Jun 6;385(9984):2264-2271. doi: 10.1016/S0140-6736(14)61730-X Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 Dec 15;375(24):2349-2358. doi: 10.1056/NEJMoa1605086.  The Cochrane review and MI-GENES study which showed that genetic information did not change lifestyle behavior Hollands GJ, French DP, Griffin SJ, Prevost AT, Sutton S, King S, Marteau TM. The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis. BMJ. 2016 Mar 15;352:i1102. doi: 10.1136/bmj.i1102.  Kullo IJ, et al. Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial). Circulation. 2016 Mar 22;133(12):1181-8. doi: 10.1161/CIRCULATIONAHA.115.020109  

This episode is sponsored by: My Financial CoachYou trained to save lives—who's helping you save your financial future? My Financial Coach connects physicians with CFP® Professionals who specialize in your complex needs. Whether it's crushing student loans, optimizing investments, or planning for retirement, you'll get a personalized strategy built around your goals. Save for a vacation home, fund your child's education, or prepare for life's surprises—with unbiased, advice-only planning through a flat monthly fee. No commissions. No conflicts. Just clarity.Visit myfinancialcoach.com/physiciansguidetodoctoring to meet your financial coach and find out if concierge planning is right for you._______________In this episode, host Dr. Bradley Block welcomes Jonathan Jarry to tackle the persistent myth that medical error is the third leading cause of death in the US. Jarry traces the claim to a 2000 Institute of Medicine report and a 2016 BMJ paper co-authored by Dr. Marty Makary, exposing their flawed extrapolations from small, non-representative studies. He highlights issues like erroneous assumptions, small sample sizes, and the challenge of determining causality in deaths linked to errors. Jarry explains how this inflated statistic fuels fear, drives patients toward unproven alternative treatments, and erodes trust in healthcare. He offers practical ways to push back against the myth while acknowledging the need for improved patient safety systems. This episode is essential for healthcare professionals and patients seeking clarity on medical errors and their true impact.Three Actionable TakeawaysChallenge the Statistic with Facts – When confronted with the claim that medical error is the third leading cause of death, explain that it stems from flawed extrapolations (e.g., 62% of hospital deaths attributed to errors is unrealistic) and cite more reliable estimates (0.6%–5% of hospital deaths).Promote Patient Safety Transparently – Acknowledge medical errors as a real issue but emphasize ongoing efforts to improve safety, like rigorous error reporting systems, to maintain trust without dismissing legitimate concerns.Educate on Context – Share that small, non-representative studies (e.g., Medicare patients or regional data) were misused to inflate error rates, encouraging patients to seek evidence-based care rather than unproven alternatives.About the ShowSucceed In Medicine  covers patient interactions, burnout, career growth, personal finance, and more. If you're tired of dull medical lectures, tune in for real-world lessons we should have learned in med school!About the GuestJonathan Jarry is a science communicator with McGill University's Office for Science and Society (OSS), dedicated to separating sense from nonsense in science. With a background in clinical lab work and podcasting, he tackles pseudoscience and misinformation, making complex topics accessible. His work at OSS, established in 1999, focuses on debunking myths and promoting evidence-based understanding.Website: mcgill.ca/ossBlueSky: https://bsky.app/profile/jonathanjarry.bsky.socialAbout the host:Dr. Bradley Block – Dr. Bradley Block is a board-certified otolaryngologist at ENT and Allergy Associates in Garden City, NY. He specializes in adult and pediatric ENT, with interests in sinusitis and obstructive sleep apnea. Dr. Block also hosts The Succeed In Medicine  podcast, focusing on personal and professional development for physiciansWant to be a guest?Email Brad at brad@physiciansguidetodoctoring.com  or visit www.physiciansguidetodoctoring.com to learn more!Socials:@physiciansguidetodoctoring on Facebook@physicianguidetodoctoring on YouTube@physiciansguide on Instagram and Twitter  This medical podcast is your physician mentor to fill the gaps in your medical education. We cover physician soft skills, charting, interpersonal skills, doctor finance, doctor mental health, medical decisions, physician parenting, physician executive skills, navigating your doctor career, and medical professional development. This is critical CME for physicians, but without the credits (yet). A proud founding member of the Doctor Podcast Network!Visit www.physiciansguidetodoctoring.com to connect, dive deeper, and keep the conversation going. Let's grow! Disclaimer:This podcast is for informational purposes only and is not a substitute for professional medical, financial, or legal advice. Always consult a qualified professional for personalized guidance.

Un nouvel épisode du Pharmascope est disponible! Dans ce 161e épisode, Nicolas et Isabelle reçoivent une nouvelle invitée pour discuter de nouveautés pharmacothérapeuthiques: le fezolinetant et roflumilast topique! Les objectifs pour cet épisode sont les suivants: Résumer les bénéfices et les risques associés à ces nouvelles thérapies. Expliquer les avantages et les inconvénients de ces thérapies. Discuter de la place des nouvelles thérapies dans l'arsenal thérapeutique Ressources pertinentes en lien avec l'épisode  FezolinetantNappi RE et coll. Treating moderate-to-severe menopausal vasomotor symptoms with fezolinetant: analysis of responders using pooled data from two phase 3 studies (SKYLIGHT 1 and 2). Menopause. 2024 Jun 1;31(6):512-521. Lederman S et coll. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet. 2023 Apr 1;401(10382):1091-1102. Johnson KA et coll. Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated With Menopause: A Phase 3 RCT. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1981-1997. Ruan X et coll. Efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms associated with menopause among women in East Asia: a phase 3 randomized study (MOONLIGHT I). J Int Med Res. 2024 May;52(5):3000605241247684. Schaudig K et coll. Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial. BMJ. 2024 Nov 18;387:e079525. Douxfils J, Boretti E, Beaudart C, Dogné JM. Letter to the Editor Regarding: Safety of Fezolinetant for Treatment of Moderate-to-Severe Vasomotor Symptoms Due to Menopause: Pooled Analysis of Three Randomized Phase 3 Studies. Adv Ther. 2025 Aug;42(8):4089-4091. Roflumilast topiqueLebwohl MG et coll. Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials. JAMA. 2022 Sep 20;328(11):1073-1084. Simpson EL et coll. Roflumilast Cream, 0.15%, for Atopic Dermatitis in Adults and Children: INTEGUMENT-1 and INTEGUMENT-2 Randomized Clinical Trials. JAMA Dermatol. 2024 Nov 1;160(11):1161-1170. Blauvelt A et coll. Roflumilast foam 0.3% for adolescent and adult patients with seborrheic dermatitis: A randomized, double-blinded, vehicle-controlled, phase 3 trial. J Am Acad Dermatol. 2024 May;90(5):986-993.

Dominic Perry from the History of Egypt podcast joins us on the show to discuss the mythology of Egypt, its early history, and the state of Egyptian history at around about the time the fall of Troy is set in the 1180s BCE. Expect tales of conspiracies against Ramesses III, Sea Peoples, strife, and a look ahead at later Egyptian history and the last hieroglyphic inscriptions...Thanks so much to Dominic for appearing on the show! Find his podcast here:YouTube: @AncientEgyptHistWebsite: www.egyptianhistorypodcast.comInstagram: @egyptpodcastTikTok: @ancientegypthisSources and further reading for this episode:Blakemore, E., National Geographic (2024), Who killed Ramesses III? How science solved an Ancient Egyptian murder mystery (online) (Accessed 13/07/2025).Hawass, Z., Gad, Y. Z., Ismail, S., Khairat, R., Fathalla, D., Hasan, N., Ahmed, A., Elleithy, H., Ball, M., Gaballah, F., Wasef, S., Fateen, M., Amer, H., Gostner, P., Selim, A., Zink, A. and Pusch, C. M. (2010), Ancestry and Pathology in King Tutankhamun's Family. JAMA 303(7): 638-647.Hawass, Z., Ismail, S., Selim, A., Saleem, S. N., Fathalla, D., Wasef, S., Gad, A. Z., Saad, R., Fares, S., Amer, H., Gostner, P., Gad, Y. Z., Pusch, C. M. and Zink, A. R. (2012), Revisiting the harem conspiracy and death of Ramesses III: anthropological, forensic, radiological, and genetic study. BMJ 345: e8268.Salah El Dien, M. M., Assem, R. and Joseph, A. (2023), The Harem Conspiracies of Ancient Egypt. Wong, J. Y. (2025), The afterlife of Hatshepsut's statuary. Antiquity 99(405), 746-761.

Sheila Dillon looks into claims that big food companies wield too much influence over government decisions and public health. The episode follows news from the youth-led campaign group BiteBack2030, which says its billboard campaign has been effectively silenced. The group recently organised a mock inquiry in Parliament, involving MPs, to share concerns about how junk food advertising and sponsorship are affecting the health of children in the UK.Sheila also hears from a group of protesters who marched to Downing Street this month, shouting the message “Fight Fake Food.” Organiser Rosalind Rathouse, from the Cookery School on Portland Street, says the public needs to know how the food they're eating is damaging their health. She is calling on everyone to learn to cook this summer. During the march, campaigners delivered a list of wishes to Downing Street, highlighting the changes they'd like to see in food policy.Also featured are Jennifer Richardson from The BMJ, which has been investigating the impact of commercial influence on children's health, and Cathy Cliff from the Soil Association, who submitted a Freedom of Information request to uncover the extent of food industry lobbying and its effect on government policy.Presented by Sheila Dillon Produced for BBC Audio in Bristol by Natalie Donovan

From The Simpsons' Big Book of British Smiles to Austin Powers' ochre-tinged grin, American culture can't stop bad-mouthing English teeth. But why? Are they worse than any other nation's? June Thomas drills down into the origins of the stereotype, and discovers that the different approaches to dentistry on each side of the Atlantic have a lot to say about our national values. In this episode, you'll hear from historians Mimi Goodall, Mathew Thomson, and Alyssa Picard, author of Making the American Mouth; and from professor of dental public health Richard Watt. This episode was written by June Thomas and edited and produced by Evan Chung, Decoder Ring's supervising producer. Our show is also produced by Willa Paskin, Katie Shepherd, and Max Freedman. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Sources for This Episode Goodall, Mimi. “Sugar in the British Atlantic World, 1650-1720,” DPhil dissertation, Oxford University, 2022. Mintz, Sidney. Sweetness and Power: The Place of Sugar in Modern History, Penguin Books, 1986. Picard, Alyssa. Making the American Mouth: Dentists and Public Health in the Twentieth Century, Rutgers University Press, 2009.  Thomson, Mathew. “Teeth and National Identity,” People's History of the NHS. Trumble, Angus. A Brief History of the Smile, Basic Books, 2004. Wynbrandt, James. The Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces, St. Martin's Griffin, 2000. Watt, Richard, et al. “Austin Powers bites back: a cross sectional comparison of US and English national oral health surveys,” BMJ, Dec. 16, 2015. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

From The Simpsons' Big Book of British Smiles to Austin Powers' ochre-tinged grin, American culture can't stop bad-mouthing English teeth. But why? Are they worse than any other nation's? June Thomas drills down into the origins of the stereotype, and discovers that the different approaches to dentistry on each side of the Atlantic have a lot to say about our national values. In this episode, you'll hear from historians Mimi Goodall, Mathew Thomson, and Alyssa Picard, author of Making the American Mouth; and from professor of dental public health Richard Watt. This episode was written by June Thomas and edited and produced by Evan Chung, Decoder Ring's supervising producer. Our show is also produced by Willa Paskin, Katie Shepherd, and Max Freedman. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Sources for This Episode Goodall, Mimi. “Sugar in the British Atlantic World, 1650-1720,” DPhil dissertation, Oxford University, 2022. Mintz, Sidney. Sweetness and Power: The Place of Sugar in Modern History, Penguin Books, 1986. Picard, Alyssa. Making the American Mouth: Dentists and Public Health in the Twentieth Century, Rutgers University Press, 2009.  Thomson, Mathew. “Teeth and National Identity,” People's History of the NHS. Trumble, Angus. A Brief History of the Smile, Basic Books, 2004. Wynbrandt, James. The Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces, St. Martin's Griffin, 2000. Watt, Richard, et al. “Austin Powers bites back: a cross sectional comparison of US and English national oral health surveys,” BMJ, Dec. 16, 2015. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

From The Simpsons' Big Book of British Smiles to Austin Powers' ochre-tinged grin, American culture can't stop bad-mouthing English teeth. But why? Are they worse than any other nation's? June Thomas drills down into the origins of the stereotype, and discovers that the different approaches to dentistry on each side of the Atlantic have a lot to say about our national values. In this episode, you'll hear from historians Mimi Goodall, Mathew Thomson, and Alyssa Picard, author of Making the American Mouth; and from professor of dental public health Richard Watt. This episode was written by June Thomas and edited and produced by Evan Chung, Decoder Ring's supervising producer. Our show is also produced by Willa Paskin, Katie Shepherd, and Max Freedman. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Sources for This Episode Goodall, Mimi. “Sugar in the British Atlantic World, 1650-1720,” DPhil dissertation, Oxford University, 2022. Mintz, Sidney. Sweetness and Power: The Place of Sugar in Modern History, Penguin Books, 1986. Picard, Alyssa. Making the American Mouth: Dentists and Public Health in the Twentieth Century, Rutgers University Press, 2009.  Thomson, Mathew. “Teeth and National Identity,” People's History of the NHS. Trumble, Angus. A Brief History of the Smile, Basic Books, 2004. Wynbrandt, James. The Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces, St. Martin's Griffin, 2000. Watt, Richard, et al. “Austin Powers bites back: a cross sectional comparison of US and English national oral health surveys,” BMJ, Dec. 16, 2015. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

From The Simpsons' Big Book of British Smiles to Austin Powers' ochre-tinged grin, American culture can't stop bad-mouthing English teeth. But why? Are they worse than any other nation's? June Thomas drills down into the origins of the stereotype, and discovers that the different approaches to dentistry on each side of the Atlantic have a lot to say about our national values. In this episode, you'll hear from historians Mimi Goodall, Mathew Thomson, and Alyssa Picard, author of Making the American Mouth; and from professor of dental public health Richard Watt. This episode was written by June Thomas and edited and produced by Evan Chung, Decoder Ring's supervising producer. Our show is also produced by Willa Paskin, Katie Shepherd, and Max Freedman. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Sources for This Episode Goodall, Mimi. “Sugar in the British Atlantic World, 1650-1720,” DPhil dissertation, Oxford University, 2022. Mintz, Sidney. Sweetness and Power: The Place of Sugar in Modern History, Penguin Books, 1986. Picard, Alyssa. Making the American Mouth: Dentists and Public Health in the Twentieth Century, Rutgers University Press, 2009.  Thomson, Mathew. “Teeth and National Identity,” People's History of the NHS. Trumble, Angus. A Brief History of the Smile, Basic Books, 2004. Wynbrandt, James. The Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces, St. Martin's Griffin, 2000. Watt, Richard, et al. “Austin Powers bites back: a cross sectional comparison of US and English national oral health surveys,” BMJ, Dec. 16, 2015. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's episode features guest host Michael Upshall (guest editor, Charleston Briefings) who talks with Damien Pattinson, Executive Director, eLife Sciences Publications, Ltd. Damien earned his PhD in neuroscience. After a postdoc at Kings College, London, UK, he began his career in scholarly publishing almost twenty years ago, first joining BMJ as a scientific editor, then PLOS ONE as executive director and then as editorial director, and Research Square as VP of Publishing Innovation.  Damien joined eLife in 2020. In this conversation, he talks about Open Science and the eLife publishing model.  LinkedIn: https://www.linkedin.com/in/mupshall/ https://www.linkedin.com/in/damian-pattinson-b054508/ Twitter: Keywords:  #eLife #OpenScience #OpenResearch #Research #FutureOfResearch #ResearchIntegrity #AcademicResearch #OpenAccess #OpenSource #PeerReview #HigherEducation #LibraryInnovation #Innovation #LibraryJobs #career #collaboration #scholcomm #ScholarlyCommunication #libraries #librarianship #LibraryNeeds #LibraryLove #ScholarlyPublishing #AcademicPublishing #publishing #LibrariesAndPublishers #podcasts

If you've been in a high street pharmacy or supermarket recently, chances are you'll have seen home test kits for all sorts of indications; blood sugar level, vitamin deficiencies, thyroid function, and even some forms of cancer. A new series of article in The BMJ revealing serious concerns with the reliability of these home tests, and raises questions about their regulation. Jonathan Deeks, professor of Biostatistics at the University of Birmingham, joins us to discuss what these tests are, and how his team have rated their usability. Also this week, the sad death of a child in Liverpool from measles highlights the growing outbreak in the UK - and this may be one of the first times many doctors have come across the infection. Frances Dutton, GP at the Small Heath Medical Practice reminds us how to recognise the sign of the infection.   Reading list Direct-to-consumer self-tests sold in the UK in 2023 How to recognise and manage measles

In this episode of RAPM Focus, Editor-in-Chief Brian Sites, MD, discusses the use of buprenorphine for acute pain management with Thomas Hickey, MD, MS, following the February 2025 publication of “Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials.” Dr. Hickey is full-time staff at the West Haven VA where he is medical director of preoperative evaluation and the PACU, and site director for the anesthesiology residency. Within the VA, he is chairman of the VA New England Healthcare System committee on preoperative evaluation and ERAS, co-chair of the VA's national pain/opioid consortium for research workgroup on perioperative management of medications for opioid use disorder, and a member of the National Anesthesia Program Acute Pain Management Committee. He is board certified in both anesthesiology and addiction medicine. His research interests focus on the overlap between addiction medicine and acute pain management, particularly on the use of buprenorphine for acute pain management. He and his wife are kept busy by their three kids and all their activities. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.

Professor Gillian Leng, President of the Royal Society of Medicine was asked to carry out an independent review into the role of physician and anaesthetic associates. She sits down with Kamran Abbasi, editor in chief of The BMJ, to discuss her findings. In the UK, the rollout of physician associates, NHS staff who took on some of the tasks of doctors, has been both haphazard and controversial. Originally copied from similar roles in the U.S., British PAs were introduced in the early 2000s. The level of clinical responsibility they were asked to take on began to vary around the country, driven mostly by the workforce needs of individual Trusts. The lack of clarity about their roles lead to disquiet with doctors, worry for patients, and an increasingly toxic debate on social media. 01.00 What is the Leng Review? 10:00 Recommendation one: Renaming 14:00 Recommendation two: Easier identification 16:00 Recommendation three: How to work? 20:00 Recommendation four: Diagnosis 25:00 Recommendation five: Oversight & Regulation 32:00 Prescribing and ordering ionizing radiation? 40:00 A failure of workforce planning and vision ? 49:00 The NHS 10 year plan

With Britain's resident doctors due to walk off the job tomorrow, the government is planning changes to the law that could make this kind of strike more common.This podcast was brought to you thanks to the support of readers of The Times and The Sunday Times. Subscribe today: http://thetimes.com/thestoryGuest: Eleanor Hayward, Health Editor, The Times.Host: Manveen Rana.Producer: Hannah Varrall.Read more: How much do resident doctors earn? The BMA's claims examinedClips: Labour Party, PoliticsJoe, The BMJ, BMAtv, BBC, Sky News.Photo: Getty Images.Get in touch: thestory@thetimes.com. Hosted on Acast. See acast.com/privacy for more information.

What is death anxiety?  We spend the first 15 minutes of the podcast addressing this question.  And maybe this was unfair to our guests, the fabulous dynamic duo of palliative psychiatrists Dani Chammas and Keri Brenner (listen to their prior podcasts on therapeutic presence and the angry patient).  After all, we invited them on to our podcast to discuss death anxiety, then Eric and I immediately questioned if death anxiety was the best term for what we want to discuss! Several key points stood out to me from this podcast, your key points may differ: The “anxiety” in “death anxiety” is not a pathological phenomenon or a DSM diagnosis;  it references an existential concern that is fundamental to the human experience .  To me,” awareness of mortality” might be a better term, but in fairness, the idea of “death anxiety” was coined well before the formal establishment of “anxiety disorders.” The ways in which death anxiety manifests in our patient's choices and behaviors varies tremendously, and our responses as clinicians must be individualized. There is no “one size fits all” approach. In one example Dani discusses, a pain level of 1.5/10 might be overwhelming, because for a patient  in remission from cancer any pain might signal return of cancer.  Some manifestations of death anxiety can be debilitating, others lead to tremendous personal growth, connection to others, and a drive toward finding meaning in their illness experience.   Death anxiety impacts us as clinicians, not only through countertransference, that word that I still can't define (sorry Dani and Keri!), but also through our own unexamined fears about death. As clinicians who regularly care for people who are dying, we might find ourselves becoming “used to” death. Is this a sign that we are inured to the banality of death, and less able to empathize with the death anxiety experienced by our patients or their families? Or could it reflect our acceptance of the finitude of life, prompting us to live in the present moment? Perhaps it is something else entirely. The key is that looking inwards to understanding our own unique relationship with mortality can deepen our ability to authentically accompany the experiences of our patients. I mean, don't fear the reaper, right?  Sorry, no cowbell in my version, but you do get my son Kai, home from college, on guitar for the audio only podcast version. Here are some resources for listeners wanting to learn more about this topic: Books: Yalom ID. Existential Psychotherapy. New York, NY: Basic Books; 1980. Yalom ID. Staring at the Sun: Overcoming the Terror of Death. San Francisco, CA: Jossey-Bass; 2008. Solomon S, Greenberg J, Pyszczynski T. The Worm at the Core: On the Role of Death in Life. New York, NY: Random House; 2015. Becker E. The Denial of Death. Free Press; 1973. Articles: Emanuel LL, Solomon S, Chochinov HM, et al. Death Anxiety and Correlates in Cancer Patients Receiving Palliative Care. J Palliat Med. 2023;26(2):235-243. Chochinov HM, McClement SE, Hack TF, et al. Death anxiety and correlates in cancer patients receiving outpatient palliative care. J Palliat Med. 2023;26(12):1404–1410. doi:10.1089/jpm.2022.0052. Clark D. Between hope and acceptance: the medicalisation of dying. BMJ. 2002;324(7342):905–907. doi:10.1136/bmj.324.7342.905. Vess M, Arndt J, Cox CR, Routledge C, Goldenberg JL. The terror management of medical decisions: The effect of mortality salience and religious fundamentalism on support for faith-based medical intervention. J Pers Soc Psychol. 2009;97(2):334–350. Menzies RE, Zuccala M, Sharpe L, Dar-Nimrod I. The effects of psychosocial interventions on death anxiety: A meta-analysis and systematic review of randomized controlled trials. J Anxiety Disord. 2018;59:64–73. doi:10.1016/j.janxdis.2018.09.00 Brown TL, Chown P, Solomon S, Gore G, De Groot JM. Psychosocial correlates of death anxiety in advanced cancer: A scoping review. Psychooncology. 2025;34(1):45–56. doi:10.1002/pon.70068. Tarbi EC, Moore CM, Wallace CL, Beaussant Y, Broden EG, Chammas D, Galchutt P, Gilchrist D, Hayden A, Morgan B, Rosenberg LB, Sager Z, Solomon S, Rosa WE, Chochinov HM. Top Ten Tips Palliative Care Clinicians Should Know About Attending to the Existential Experience. J Palliat Med. 2024 Oct;27(10):1379-1389. doi: 10.1089/jpm.2024.0070. Epub 2024 Mar 28. PMID: 38546453.  

According to research published in The BMJ in 2002, around 40% of people experience some age-associated memory impairment after reaching 65. Thankfully only 1% of those affected will then go on to have dementia each year. But still, it's important to be aware of how effective your memory is, whatever your age. An impairment can be a sign of cognitive decline, which becomes more likely the older we get. How does our memory actually work? What happens when we have a memory lapse then? In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here: ⁠Can you really lose weight by walking?⁠ ⁠Can you improve your relationship by learning your love language?⁠ ⁠Are you spending more on groceries due to stretchflation?⁠ A podcast written and realised by Joseph Chance. First Broadcast: 11/9/2024 Learn more about your ad choices. Visit megaphone.fm/adchoices

If you're anything like me, you've probably looked back and thought, “Why didn't I know this 10 years ago?” That's exactly what today's chat is about - my top five health game-changers I wish I had embraced earlier. Whether you're 25 or 75, these insights can shift the needle in how you feel, look, and thrive. From nutrition tracking without guilt to finally getting that high-quality protein in, these tips aren't about restriction - they're about empowerment. I'm opening up about what's worked, what didn't, and why strength training, ditching the processed stuff, and even allowing yourself to be hungry can be revolutionary. This one is packed with real-life examples, scientific backing, and simple steps to get started without getting overwhelmed. What we're tackling: Track your food with intention, not shame. Ditch skinny, build strong with progressive overload. Prioritize protein without obsessing. Phase out processed foods gradually. Embrace hunger and stop snacking aimlessly. Meditation App : Simply Being App Get Weekly Health Tips:  thrivehealthcoachllc.com Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You! Sources: Tracking Nutrition Burke, L. E., Wang, J., & Sevick, M. A. (2011). Self-monitoring in weight loss: A systematic review of the literature. Journal of the American Dietetic Association, 111(1), 92–102. https://doi.org/10.1016/j.jada.2010.10.008 Raber, M., Patterson, M., & Jia, W. (2021). A systematic review of the use of dietary self-monitoring in behavioral weight-loss interventions: Current practices and future recommendations. Public Health Nutrition, 24(17), 5885–5913. https://doi.org/10.1017/S1368980021002381 Prioritizing High-Quality Protein Holt, S. H. A., Brand Miller, J. C., Petocz, P., & Farmakalidis, E. (1995). A satiety index of common foods. European Journal of Clinical Nutrition, 49(9), 675–690. Ortinau, L. C., Culp, J. M., & Hoertel, H. A. (2014). Effects of high-protein vs. high-fat snacks on appetite control, satiety, and eating initiation in healthy women. Nutrition Journal, 13, 97. https://doi.org/10.1186/1475-2891-13-97 Dhillon, J., Craig, B. A., Leidy, H. J., Amankwaah, A. F., Jacobs, A., Jones, B. L., & Jones, J. B. (2016). The effects of increased protein intake on fullness: A meta-analysis and its limitations. Journal of the Academy of Nutrition and Dietetics, 116(6), 968–983. https://doi.org/10.1016/j.jand.2016.01.003 Zhu, R., et al. (2021). Effect of a high-protein, low-glycemic index diet on hunger and weight maintenance: Results from the PREVIEW study. Frontiers in Nutrition, 8, 649928. https://doi.org/10.3389/fnut.2021.649928 Strength Training vs. Cardio Saeidifard, F., Medina-Inojosa, J. R., West, C. P., & Lopez-Jimenez, F. (2019). The role of resistance training in the prevention and management of chronic disease. European Journal of Preventive Cardiology, 26(5), 505–515. https://doi.org/10.1177/2047487318822333 Momma, H., et al. (2022). Muscle-strengthening activities and risk of all-cause and cause-specific mortality: A systematic review and meta-analysis of cohort studies. British Journal of Sports Medicine, 56(10), 755–763. https://doi.org/10.1136/bjsports-2021-105061 Cutting Ultra-Processed Foods Monteiro, C. A., Cannon, G., Levy, R. B., Moubarac, J. C., Louzada, M. L., Rauber, F., ... & Jaime, P. C. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936–941. https://doi.org/10.1017/S1368980018003762 Srour, B., et al. (2019). Ultra-processed food intake and risk of cardiovascular disease: Prospective cohort study (NutriNet-Santé). BMJ, 365, l1451. https://doi.org/10.1136/bmj.l1451 Mindful Hunger / Fasting Bruce, L. J., & Ricciardelli, L. A. (2016). A systematic review of the psychosocial correlates of intuitive eating among adult women. Appetite, 96, 454–472. https://doi.org/10.1016/j.appet.2015.10.012 Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metabolism, 23(6), 1048–1059. https://doi.org/10.1016/j.cmet.2016.06.001

Last December, The BMJ published an investigation into the 2009 PLATO trial - exposing serious problems with that study's data analysis and reporting.  Our follow up investigation has shown that those data problems extend to other key supporting evidence in AstraZeneca's initial application to regulators. Peter Doshi, senior editor in the BMJ's Investigations unit, and Rita Redberg, cardiologist and Professor of Medicine at UCSF and former editor of JAMA Internal Medicine, join us to explain what this means for scientific integrity, and trust in the FDA's approval processes.   Also in this episode. A group of international authors are arguing that weightloss advice given in primary care might actually be doing more harm than good - it's ineffective and potentially reinforces damaging stigma.  To explain why they came to that conclusion we're joined by Juan Franco editor in chief of BMJ EBM, and a practicing GP in Germany, and Emma Grundtvig Gram, from the Centre for General Practice at the University of Copenhagen Reading list Doubts over landmark heart drug trial: ticagrelor PLATO study Ticagrelor doubts: inaccuracies uncovered in key studies for AstraZeneca's billion dollar drug Beyond body mass index: rethinking doctors' advice for weight loss

In this episode of RAPM Focus, Editor-in-Chief Brian Sites, MD, speaks with RAPM Editor Ryan D'Souza, MD, and Nasir Hussain, MD, following the October 2024 publication of “Hidden Influence? Unmasking Conflicts of Interest from Randomized Clinical Trials on Spinal Cord Stimulation for Chronic Pain.” Let's set the stage first. Spinal cord stimulation, or SCS, is a therapy that involves implanting a device that sends electrical signals to the spinal cord, aiming to disrupt pain signals before they reach the brain. It's a rapidly evolving field with a lot of promise, but it also attracts substantial investment from medical device companies. Now, when we talk about conflicts of interest, or COIs, we're referring to situations where a researcher's personal interests, particularly financial ones, have the potential to cloud their professional judgment and influence the outcomes of their research. Think of it this way: if a researcher is financially tied to a company that makes a specific SCS device, might they be more inclined to see their research results in a favorable light? That's the concern. Dr. Ryan D'Souza is an associate professor and pain medicine physician at Mayo Clinic. He is the Director of Neuromodulation, and Director of the Inpatient Pain Service. He serves on the Board of Directors of the North American Neuromodulation Society and also serves in leadership roles for ASRA Pain Medicine. Dr. D'Souza has authored over 150 peer-reviewed publications and serves on several editorial boards. Dr. Nasir Hussain is a pain medicine physician and anesthesiologist at the Ohio State University. He is an assistant professor, associate program director for the anesthesiology residency, and assistant program director of the chronic pain fellowship. Dr. Hussain has authored over 110 peer-reviewed publications in leading journals in the field, and has presented his work nationally at several conferences. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.

Meningitis remains a major global health threat, with an estimated 2.5 million cases each year; of these, one in six results in death and one in five in long-term disabilities. Although meningitis “can strike anyone, anywhere in the world,” outbreaks disproportionately impact low- and middle-income countries, where diagnostic and treatment resources are limited. In efforts to address this, WHO launched its first-ever guideline on meningitis diagnosis and management in April this year. In this episode of Communicable, hosts Emily McDonald and Marc Bonten are joined by two experts directly involved in creating the guideline, Lorenzo Pezzoli and Nicolò Binello (WHO), as well as Jacob Bodilsen (Aalborg University), clinician-researcher and Chair of ESCMID's Study Group for Infectious Diseases of the Brain (ESGIB). The guests offer a firsthand look behind the guideline's development, review key recommendations for diagnosis and treatment - including the use of lumbar puncture, antibiotics, and chemoprophylaxis – and discuss how these fit into various clinical settings. This episode was edited by Kathryn Hostettler and peer reviewed by Ljiljana Lukić of University Hospital for Infectious Diseases in Zagreb, Croatia. The executive producer of Communicable is Angela Huttner. TermsCRP, C-reactive proteinGDG, Guideline Development GroupLiterature WHO guidelines on meningitis diagnosis, treatment and care. April 2025. https://www.who.int/publications/i/item/9789240108042Defeating meningitis by 2030: a global road map. June 2021. https://www.who.int/publications/i/item/9789240026407Olie SE, et al. Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis: a prospective diagnostic accuracy study. Lancet Reg June 2025. DOI: 10.1016/j.lanepe.2025.101309Coldiron ME, et al. Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial. PloS Med 2018. DOI: 10.1371/journal.pmed.1002593Hasbun R, et al. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001. DOI: 10.1056/NEJMoa010399Glimåker M. Lumbar puncture in adult bacterial meningitis: time to reconsider guidelines? BMJ 2013, DOI: 10.1136/bmj.f361

Helen MacDonald and Juan Franco are back to examine the newest in evidence based medicine.   In this episode: gabapentinoids are medications routinely prescribed for treating epilepsy and nerve pain. But, they come with side effects; among them - dizziness, cognitive impairment, and a dent to motor coordination - as well as an increase in suicidal ideation for the patient. Seena Fazel is professor of forensic psychiatry at University of Oxford and joins Juan to discuss a new paper tracking the association of self-harm and gabapentinoids use in Sweden.   Meanwhile, GRADE is a fundamental tool for clinicians to assess the quality of evidence for medical interventions. But, the sheer number of recommendations in the GRADE series can be overwhelming. Gordon Guyatt is a distinguished professor of medicine at McMaster University in Canada, and an early figure in the rise of evidence based medicine. He joins Helen to reflect on the future of EBM, and how the new Core GRADE system can cut through the noise.   Reading list:   1. Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden 2. Why Core GRADE is needed: introduction to a new series in The BMJ  

Send us a textHey my beautiful friends –This week's conversation was sparked by a funny little tech discovery and a box I mailed — both of which got me thinking about food in a new way. You know how people are always quick to tell you what not to eat? Well, this week we flip the script. I'm sharing thoughts from my own journey and a coach that made me laugh and think — and you'll hear why his words still stick with me to this day. We're keeping things simple, kind, and grounded in something real. I'm not handing out rules, I'm sharing a mindset and maybe even a little inspiration for your next grocery run or packed lunch. And as always, we'll close with a little heart lift — this one from Michael Pollan, who said, “Eat food. Not too much. Mostly plants.”Come hang out with me, and let's talk about what loves us back. References:1.    Zhang & Talalay, Frontiers in Nutrition, 20232.    Liu, Nutrients, 20233.    Viguiliouk et al., Obesity Reviews, 20234.    Jenkins et al., AJCN, 20245.    Estruch et al., The Lancet Diabetes & Endocrinology, 20236.    Guasch-Ferré et al., BMJ, 20237.    Yao et al., Nutrients, 20238.    Harvard Nurses' Health Study Update, 20239.    Anderson et al., AJCN, 202410.Simopoulos, Frontiers in Endocrinology, 202311.Ye et al., Nutrients, 202312.Sonnenburg et al., Cell Metabolism, 202413.Mozaffarian et al., AJCN, 202314.Mastrocola et al., Appetite, 202315.Pollan, M. (2009). In Defense of FoodLet's go, let's get it done. Get more information at: http://projectweightloss.org

Hello everyone! Thanks to Tom's holiday and Stuart's job we weren't able to record this week, so we've put out a classic paid episode to tide you over. We hope this goes some way to scratching your Studies Show itch.Most people think it's obvious that you should wear a helmet when cycling. It might save your life if you fall off and hit your head. Duh.But over the years, many contrarian arguments have pushed back against this seemingly-obvious point. What if people engage in “risk compensation”, where they cycle more dangerously because they know they're wearing a helmet? What about if encouraging helments puts people off cycling so they miss the health benefits?In this March 2024 episode of The Studies Show, Tom and Stuart try to work out who's right.Show notes* The original 1975 study on what's become known as the “Peltzman Effect”: risk compensation (in this case about car safety)* Potential evidence for risk compensation in AIDS* Claims of risk compensation relating to mask-wearing at the start of the COVID-19 pandemic* The eye-tracking study on helmet-wearing, which used the Balloon Analogue Risk-Taking lab task* n=27 study on helmets and cycling with one hand on the handlebar* Study on risk compensation with the following confusing structural equation model diagram:* Academic cycles around and records thousands of cars passing him while he's either wearing or not wearing a helmet* Forbes article about the statistical controversy over these data* Bizarre study on how motorists “dehumanize” cyclists* Could helmets make “rotational injuries” worse?* Cochrane review on cycle helmets and injuries from 1999* Ben Goldacre and David Spiegelhalter on cycle helmets - “uncertainty… is unlikely to be substantially reduced by further research”* Systematic review on helmet use and injuries from 2016* Review of meta-analyses from 2023* 2006 BMJ article finding “no clear evidence” that mandating cycle helmets reduces injuries* Negative correlation between cycle numbers and helmet usage, across different countriesCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

Listener feedback on sports “disqualification,” big digoxin news, Brugada syndrome, another positive finerenone study, and unblinded transcatheter trials are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback JACC EP Paper https://www.jacc.org/doi/10.1016/j.jacep.2025.03.013 II Digoxin News DIGIT HF Baseline Characteristics paper https://doi.org/10.1002/ejhf.3679 DIGIT HF Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC6607489/ Dig trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801 DECISION trial https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3428 Ziff et al BMJ meta-analysis https://www.bmj.com/content/351/bmj.h4451 III Brugada Syndrome Gomes et al https://doi.org/10.1093/europace/euaf091 IV Another Finerenone Substudy Published FINEARTS-HF trial substudy, Bhatt, A et al https://doi.org/10.1016/j.cardfail.2025.05.006 FINEARTS HF Main paper https://www.nejm.org/doi/full/10.1056/NEJMoa2407107 TOPCAT https://www.nejm.org/doi/full/10.1056/NEJMoa1313731 TOPCAT regional variation Circ paper https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255 V Another Opinion on Unblinded Transcatheter Intervention Trials Kaul https://eurointervention.pcronline.com/article/unblinded-trials-of-transcatheter-interventions-with-subjective-endpoints-what-are-the-implications You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

A Lancet study warns of consequences for HIV prevention if PEPFAR loses funding, potentially millions of new pediatric HIV cases and increased AIDS-related deaths. Medicare Part D is highlighted, with research linking subsidy loss to higher mortality rates. A report from BMJ notes a 3.1% decline in U.S. drug overdose deaths, signaling a possible peak in the fentanyl crisis.

Recent escalations in the ever simmering tension between India and Pakistan brought us closer to conflict - conflict between two nuclear powers. For a long time doctors have campaigned for nuclear disarmament, and Chris Zielinski, president of the World Association of Medical Editors, makes the case for returning WHO's mandate to measure the potential impact of nuclear war. Also the militarization of the region is detrimental to the health and wellbeing of the populations in both India and Pakistan. co-chairs of The BMJ's South Asia editorial board, Sanjay Nagral and Zulfiqar Butta, explain why a focus on the daily material and health needs of citizens is the way to change political rhetoric in the region. Gordon Guyatt, distinguished professor at McMaster University, was one of the people responsible for starting GRADE - which is a structured system for assessing the quality of evidence in systematic reviews and clinical practice guideline. Gordon thinks that process has become too complicated - so he's now championing “Core GRADE”. He joins us to explain why.   Reading list Ending nuclear weapons, before they end us Why Core GRADE is needed: introduction to a new series in The BMJ

You are capable of radical change. If you aren't convinced that you can create change in your life, take Aimee's story about how her hen became a rooster (seriously, just listen in and it'll make sense). Beyond that chicken talk, this episode is focused on our human potential for change and healing. We'll touch on neuroplasticity, epigenetics, and the motivational role of hope. We think you'll come away with a better understanding of how you're wired for change and can intentionally steer it towards greater wellbeing.  If you enjoyed this episode, please rate and review us wherever you listen to your favorite podcasts!  Sources and Notes: Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Emotional Inertia: Feeling Dull & Disconnected [Joy Lab ep. 207] Zhang, X., et al. (2023). Overview of Avian Sex Reversal. International journal of molecular sciences, 24(9), 8284. https://doi.org/10.3390/ijms24098284 Bian, Z., et al. (2024). Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies. BMJ evidence-based medicine, 29(4), 255–263. https://doi.org/10.1136/bmjebm-2023-112583 Weger, U. W., & Loughnan, S. (2013). Mobilizing unused resources: using the placebo concept to enhance cognitive performance. Quarterly journal of experimental psychology (2006), 66(1), 23–28. https://doi.org/10.1080/17470218.2012.751117 Head to YouTube to see Haley's new spurs (16:28) Closing poem excerpt: Emily Dickinson, "Hope is the Thing With Feathers." Full transcript here. Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.

China was declared malaria free in 2021 - and we'll hear how persistence was key to their success, and what new technologies are available to help the rest of the world become malaria free, from Regina Rabinovich, director of the Malaria Elimination Initiative at the Barcelona Institute for Global Health.  Sonia Saxena, professor of primary care at Imperial College London, and Miguel O'Ryan, dean of the medical faculty of the University of Chile join Kamran to talk about what broke academic medicine, and why it's time for a revolution. New research shows that data from retracted papers is still having an alarming effect on clinical practice. Chang Xu, Hui Liu, and Fuchen Liu from the Naval Medical University in Shanghai, and Suhail Doi from Qatar University, join us to talk about their study which has maped retracted papers impact on systematic reviews and clinical guidelines.    Reading list Malaria control lessons from China Vision 2050: a revolution in academic medicine for better health for all Investigating the impact of trial retractions on the healthcare evidence ecosystem (VITALITY Study I) - An example of the BMJ's approach to updating metaanalysis after a study retraction 

Send us a textDescription: An immersive reading of A Hymn to God the Father by John Donne with reflection on medical errors and confession. Website:https://anauscultation.wordpress.comWork:A Hymn to God the Father by John DonneWilt thou forgive that sin where I begun,         Which was my sin, though it were done before?Wilt thou forgive that sin, through which I run,         And do run still, though still I do deplore?                When thou hast done, thou hast not done,                        For I have more.Wilt thou forgive that sin which I have won         Others to sin, and made my sin their door?Wilt thou forgive that sin which I did shun         A year or two, but wallow'd in, a score?                When thou hast done, thou hast not done,                        For I have more.I have a sin of fear, that when I have spun         My last thread, I shall perish on the shore;But swear by thyself, that at my death thy Son         Shall shine as he shines now, and heretofore;                And, having done that, thou hast done;                        I fear no more.References:Wu AW. Medical error: the second victim. The doctor who makes the mistake needs help too. BMJ. 2000 Mar 18;320(7237):726-7. doi: 10.1136/bmj.320.7237.726. Finkelstein A, Brezis M, Taub A, Arad D. Disclosure following a medical error: lessons learned from a national initiative of workshops with patients, healthcare teams, and executives. Isr J Health Policy Res. 2024 Mar 11;13(1):13.Rodziewicz TL, Houseman B, Vaqar S, et al. Medical Error Reduction and Prevention. [Updated 2024 Feb 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499956/Institute of Medicine (US) Committee on Quality of Health Care in America. To Err is Human: Building a Safer Health System. Kohn LT, Corrigan JM, Donaldson MS, editors. Washington (DC): National Academies Press (US); 2000. PMID: 25077248.

Welcome to Episode 45 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 45 of “The 2 View” – All things toxicology: the intoxicated patient, propranolol overdose and suicide, snake bites, and a special guest. Segment 1 – The intoxicated patient Kaufman J, Fitzpatrick P, Tosif S, et al. Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial. BMJ. The BMJ. Published April 7, 2017. https://www.bmj.com/content/357/bmj.j1341 Kraaijvanger N, Raven W, van Dijken T, Gresnigt F. The PIRATE mnemonic: providing a structured approach in the care for intoxicated patients at the emergency department. Int J Emerg Med. Educational Advances in Emergency Medicine. BMC: Part of Springer Nature. Published March 1, 2024 https://intjem.biomedcentral.com/articles/10.1186/s12245-024-00606-4 Thiessen P. A simple new technique for collecting urine in infants. Thischangedmypractice.com. The University of British Columbia. Faculty of Medicine: This Changed My Practice (TCMP) by UBC CPD. Published November 18, 2015. https://thischangedmypractice.com/new-technique-for-collecting-urine-in-infants/ Van Oyen A, Barney N, Grabinski Z, et al. Urine Toxicology Test for Children With Altered Mental Status. Aap.org. Pediatrics. Case Reports. American Academy of Pediatrics: Dedicated to the Health of All Children. Published October 6, 2023. https://publications.aap.org/pediatrics/article/152/5/e2022060861/194346/Urine-Toxicology-Test-for-Children-With-Altered?autologincheck=redirected Segment 2 – Propranolol overdose and suicide Khalid MM, Galuska MA, Hamilton RJ. Beta-Blocker Toxicity. In: StatPearls. StatPearls Publishing. NIH: National Library of Medicine – National Center for Biotechnology Information. Published July 28, 2023. https://www.ncbi.nlm.nih.gov/books/NBK448097/ Srettabunjong S. Fatal Self-Poisoning With Massive Propranolol Ingestion in a Young Male Physician. Am J Forensic Med Pathol. PubMed®. NIH: National Library of Medicine – National Center for Biotechnology Information. Published September 2017. https://pubmed.ncbi.nlm.nih.gov/28691951/ Segment 3 – Snake bites Rohl S, Meredith M, Anderson, T, et al. Comparing the Use of Crotaline-Polyvalent Immune Fab (Ovine) Versus Observation in Children. Pediatric Emergency Care: Dedicated to the Care of the Ill or Injured Child. Lww.com. Published November 2024. https://journals.lww.com/pec-online/abstract/2024/11000/comparingtheuseofcrotalinepolyvalentimmune.19.aspx Snake bites. Wikem.org. WikiEM. Last edited March 17, 2021. https://wikem.org/wiki/Snake_bites Toxicology resources Goldfrank LR, Flomenbaum NE, Howland MA, et al. Goldfrank's Toxicologic Emergencies. 8th ed. McGraw-Hill Medical; 2006. Katz K, O'Connor A, Amaducci AM. EMRA and ACMT Medical Toxicology Guide: 2nd Edition.; 2022. National Poison Data System. Poisoncenters.org. America's Poison Centers: Treatment, Education, Prevention. Accessed April 9, 2025. https://poisoncenters.org/national-poison-data-system Poison Control: National Capital Poison Center. Poison.org. Accessed April 9, 2025. https://www.poison.org/ Segment 4 – Special guest: Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona Linkedin.com. Accessed April 9, 2025. https://www.linkedin.com/in/nancy-denke-dnp-acnp-bc-fnp-bc-faen-a62851 Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona. ENA Hall of Honor. Published July 26, 2024. Accessed April 9, 2025. https://hall-of-honor.org/nancy-denke PodBean Development. Talking Toxicology: A Recipe for Disaster (Nancy Denke). BCEN & Friends Podcast. PodBean. Published March 7, 2023. https://bcenandfriends.podbean.com/e/talking-toxicology-a-recipe-for-disaster-nancy-denke/ *Recurring Sources * Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

The focus of today's episode with Mercedes Pollmeier is to get you familiar with the starting point of strength training for your climbing journey. She discusses the top injuries of climbers and why they may happen. Build body awareness by learning which muscles are engaged while climbing, and also learn how to properly press, pull, hinge, squat, and let's not forget your core. Mercedes is here to drop the knowledge about what to prioritize for strength training, while improving mobility and reducing risk of injury. Leave a comment below about what you've noticed in your strength training & how it's shown up in your climbing! Join Modus Training with this 3 month membership special! https://www.modusathletica.com/offers/C5hDL5aq If you'd like to work one-on-one with me, visit my website for more details https://www.modusathletica.com/coaching Intro To Training Masterclass is free way to work with me: https://www.modusathletica.com/masterclass 00:00:32 Common climbing injuries 00:03:08 Climbing Technique 00:05:25 Cause of Injury 00:06:44 Engaged muscles00:09:17 What should we prioritize 00:13:32 Strength exercises 00:21:22 Recap 00:22:52 A question for YOU Here's the Research Study: Grønhaug, Gudmund. “Self-reported chronic injuries in climbing: who gets injured when?.” BMJ open sport & exercise medicine vol. 4,1 e000406. 17 Jul. 2018, doi:10.1136/bmjsem-2018-000406

Chris and Cristina chat with Dr. Ian Wallace, an Assistant Professor of Anthropology at the University of New Mexico, where he is the director of the Human Physical Activity Lab. As an Evolutionary Anthropologist, Ian's work focuses on how humans evolved to use their bodies and explores the costs and benefits of modern physical activity patterns for our health. He is particularly interested in populations transitioning from non-industrial to industrial and post-industrial contexts. Ian earned his Ph.D. in Anthropology in 2013 from Stony Brook University, where his dissertation examined how physical activity and genetics determine limb bone structure. Following graduate school and an initial postdoctoral position at Stony Brook, he completed his postdoctoral training in the Department of Human Evolutionary Biology at Harvard and started his own lab at UNM. There, he focuses on measures of locomotor biomechanics and their ties to the health and function of the musculoskeletal system. Recently, his fieldwork has focused on the Indigenous peoples of Peninsular Malaysia. In particular, he is interested in how their lifestyles are changing with the rapid expansion of industries, the market economy, and urban areas across Malaysia, as well as how these changes affect their health and risk of disease. ------------------------------ Find the papers discussed in this episode: Wallace, I. J., Worthington, S., Felson, D. T., Jurmain, R. D., Wren, K. T., Maijanen, H., Woods, R. J., & Lieberman, D. E. (2017). Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proceedings of the National Academy of Sciences of the United States of America, 114(35), 9332–9336. https://doi.org/10.1073/pnas.1703856114 Wallace, I. J., Lea, A. J., Lim, Y. A. L., Chow, S. K. W., Sayed, I. B. M., Ngui, R., Shaffee, M. T. H., Ng, K. S., Nicholas, C., Venkataraman, V. V., & Kraft, T. S. (2022). Orang Asli Health and Lifeways Project (OA HeLP): a cross-sectional cohort study protocol. BMJ open, 12(9), e058660. https://doi.org/10.1136/bmjopen-2021-058660 ------------------------------ Contact Dr. Wallace: Website: https://www.ianjwallace.com/; E-mail: iwallace@unm.edu ------------------------------ Contact the Sausage of Science Podcast and Human Biology Association: Facebook: facebook.com/groups/humanbiologyassociation/, Website: humbio.org, Twitter: @HumBioAssoc Chris Lynn, Host Website: cdlynn.people.ua.edu/, E-mail: cdlynn@ua.edu, Twitter:@Chris_Ly Cristina Gildee, Co-host, SoS Co-Producer, HBA Junior Fellow Website: cristinagildee.org, E-mail: cgildee@uw.edu

A new type of drug for one of the most common types of breast cancer is now going to be available in the NHS in England. In Wales, the drug is approved for use but its funding is still to be decided, and the drug hasn't been approved for use in Scotland and Northern Ireland yet. Some 3,000 women a year could benefit after a clinical trial showed it can slow the progression of the disease. Nuala McGovern discusses how the drug works and who could benefit with Dr Liz O'Riordan, a former breast cancer surgeon who herself has had breast cancer and is currently in remission.Emily MacGregor is a music historian and trombonist. After the sudden death of her father, a jazz guitarist, she found she wasn't able to bear the sound of music. The very thing that once connected them became a source of pain and silence. In her new book, While the Music Lasts, she explains how she reconnected with her father through the pieces left on his music stand, from tangos to Handel, Cádiz to Coltrane. She joins Nuala to talk about how she learnt to navigate grief and how she discovered the joy of music again.Between 2021 and 2022 the number of women having abortions rose by 17%. A recent study in the BMJ reported that, amongst women having abortions, the number of women using hormonal contraception fell from 18.8% in 2018 to 11.3% in 2023. Over the same period, the number of women undergoing abortions who were not using any contraception when they conceived went up by 14%. So are women turning their backs on hormonal contraceptives? Does this change lie with the contraceptives themselves, women's access to contraception or could there be other factors like the increase in the use of fertility apps? Nuala speaks to Dr Paula Briggs, Consultant in Sexual & Reproductive Health, and journalist Barbara Speed.In 2014, the Church of England passed the necessary laws to allow women to become bishops. For some, this was a controversial decision. In an attempt to smooth that change the five guiding principles were introduced which allowed those who felt unable to accept women's ministry to flourish within the church. Now WATCH, Women and the Church, are calling for those provisions to be removed. Nuala speaks to Reverend Martine Oborne, Chair of WATCH, and Dr Ros Clarke, Associate Director of Church Society. Presenter: Nuala McGovern Producer: Emma Pearce

US President Donald Trump promises a significant tariff announcement on April 2. We gathered a team of experts to discuss how the looming threats of tariffs from the Trump administration may affect Brazil and reshape relations between the United States and Brazil — not just in the short-term future but also in the long run. Panelists:Tony Harrington, former US ambassador to Brazil. Founding Principal of Albright Stonebridge. He was previously Chair of the President's Intelligence Oversight Board and currently serves as Chair of the Wilson Center Brazil Institute. Kellie Meiman Hock, senior counselor at McLarty Associates and a board member of the Inter-American Dialogue. A former US Foreign Service Officer, she served in Porto Alegre, São Paulo and Recife in Brazil, as well as at the Office of the US Trade Representative in the Executive Office of the President as Director for Brazil and the Southern Cone.Welber Barral, founding partner of BMJ, is an expert in international trade and investment with over 30 years of experience. He served as Brazil's Secretary of Foreign Trade between 2007 and 2011 and has acted as an arbitrator in Mercosur and WTO disputes. He currently advises Fiesp and presides over IBCI, the Brazilian Institute of Foreign Trade.This episode is exclusive for premium subscribers and subscribers of Explaining Brazil Plus on Apple Podcasts.Support the show