Podcasts about staphylococcal

Drs. Nico Cortes-Penfield (@Cortes-Penfield), Kerry LaPlante (@Kerry_LaPlante), Jessica Seidelman (@JessieLSeidel) join Dr. Julie Ann Justo (@julie_justo) to discuss the pesky slime that is biofilm in periprosthetic joint infections. They review biofilm composition & development, have an honest discussion about whether antibiotics can ever really eradicate it, and provide updates on the promising non-pharmacologic strategies on the horizon (bacteriophages, electromagnetism, & more). Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp References Nixing the Nidus: Managing Retained Sources in Prosthetic Joint Infections. Breakpoints Podcast Episode #67. Society of Infectious Diseases Pharmacists. Dosing Consult: Rifampin Part 1. Breakpoints Podcast Episode #104. Society of Infectious Diseases Pharmacists. Review on Staphylococcal biofilm development: Schilcher K, Horswill AR. 2020 Aug 12;84(3):e00026-19. doi: 10.1128/MMBR.00026-19. PMID: 32792334. Antibiotics can fail to kill biofilm cells even if they penetrate the biofilm: Singh R, et al. Pathog Dis. 2016 Aug;74(6):ftw056. doi: 10.1093/femspd/ftw056. Epub 2016 Jul 7. PMID: 27402781. Subinhibitory antibiotic concentrations can promote biofilm formation: Schilcher K, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5957-67. doi: 10.1128/AAC.00463-16. PMID: 27458233. Clinical and genetic risk factors for biofilm-forming Staphylococcus aureus: Luther MK, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02252-17. doi: 10.1128/AAC.02252-17. PMID: 29530854. Meta-analysis showing poor clinical outcomes with debridement, antibiotics, and implant retention (DAIR): Kunutsor SK, et al. J Infect. 2018 Dec;77(6):479-488. doi: 10.1016/j.jinf.2018.08.017. PMID: 30205122. Thieme L, et al. MBEC versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology. Biol Proced Online 21, 18 (2019). https://doi.org/10.1186/s12575-019-0106-0. Ongoing trial investigating use of MBEC in the treatment of PJIs: Tillander JAN, et al. BMJ Open. 2022 Sep 15;12(9):e058168. doi: 10.1136/bmjopen-2021-058168. PMID: 36109038. Maale, G. Complete eradication of biofilm using low frequency electromagnetic force (EMF) and antibiotics at MIC. 34th Annual Meeting Musculoskeletal Infection Society. 2024 Aug. Abstract 1232 (see full program). Meta-analysis on bacteriophages for biofilm: Kovacs CJ, et al. Mil Med. 2024 May 18;189(5-6):e1294-e1302. doi: 10.1093/milmed/usad385. PMID: 37847552. Berking BB, et al. Biofilm disruption from within: light-activated molecular drill-functionalized polymersomes bridge the gap between membrane damage and quorum sensing-mediated cell death. ACS Biomater Sci Eng. 2024 Sep 9;10(9):5881-5891. doi: 10.1021/acsbiomaterials.4c01177. PMID: 39176452. Aboelnaga N, et al. Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances. Cell Commun Signal. 2024 Mar 22;22(1):188. doi: 10.1186/s12964-024-01511-2. PMID: 38519959. Conway J, et al. Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0065524. doi: 10.1128/aac.00655-24. PMID: 39012102. Mulpur P, et al. Efficacy of intrawound vancomycin in prevention of periprosthetic joint infection after primary total knee arthroplasty: a prospective double-blinded randomized control trial. J Arthroplasty. 2024 Jun;39(6):1569-1576. doi: 10.1016/j.arth.2024.01.003. PMID: 38749600. Dong Y, et al. Synergy of ultrasound microbubbles and vancomycin against Staphylococcus epidermidis biofilm. J Antimicrob Chemother. 2013 Apr;68(4):816-26. doi: 10.1093/jac/dks490. PMID: 23248238. Miltenberg B, et al. Intraosseous Regional Administration of Antibiotic Prophylaxis for Total Knee Arthroplasty: A Systematic Review. J Arthroplasty. 2023 Apr;38(4):769-774. doi: 10.1016/j.arth.2022.10.023. PMID: 36280158. Viswanathan VK, et al. Intraosseous regional antibiotic prophylaxis in total joint arthroplasty (TJA): Systematic review and meta-analysis. J Clin Orthop Trauma. 2024 Oct 3;57:102553. doi: 10.1016/j.jcot.2024.102553. PMID: 39435324. SOLARIO trial: Dudareva M, et al. The European Bone and Joint Infection Society Meeting, 2024 Sept. SOLARIO trial press release from BoneSupportTM. 2024 Oct 3. Fehring TK, et al. Does treatment at a specialized prosthetic joint infection center improve the rate of reimplantation. J Arthroplasty. 2023 Jun;38(6S):S314-7. PMID 37004968. ROADMAP trial website. 2024.

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary Chapter 3.5 Penicillins  Chapter 3.5 of the Nursing Pharmacology guide focuses on penicillins, detailing their discovery, mechanism of action, indications, administration considerations, potential side effects, and patient education. Penicillins work by interfering with bacterial cell wall synthesis, and they treat infections like Streptococcal and Staphylococcal. Nurses should monitor for allergic reactions, superinfections, and drug interactions. Proper patient teaching includes medication adherence and monitoring symptoms. Multiple Choice Questions What is the primary mechanism of action for penicillins? a) Blocking protein synthesis b) Disrupting cell wall synthesis c) Inhibiting DNA replication d) Preventing RNA transcription Which condition is penicillin commonly used to treat? a) Hypertension b) Streptococcal infections c) Diabetes d) Migraine headaches What is a common side effect of high doses of penicillin? a) Hyperglycemia b) Coagulation abnormalities c) Increased heart rate d) Dry skin Why should patients avoid taking penicillin with citrus-based products? a) It increases absorption b) It reduces absorption c) It causes stomach pain d) It increases side effects What should a patient do if they develop diarrhea while taking penicillin? a) Stop taking the medication immediately b) Treat it with over-the-counter medicine c) Contact their healthcare provider d) Drink more fluids Answer Key b) Disrupting cell wall synthesis b) Streptococcal infections b) Coagulation abnormalities b) It reduces absorption c) Contact their healthcare provider ```

Joseph is a 14 year-old, generally well and up-to-date with health maintenance, who presents for a sick with a 36 h hx of gradual onset nausea, vomiting and loose stools, reporting “I'm not sure how many times I threw up or had diarrhea.” He last vomited about 4 h ago, last stool was around 2 h ago, reported as yellow brown in color, small volume and without blood.  He has been tolerating a sips of clear liquids for the past 3 h and voided a small amount around 2 h ago. Joesph reports that he is on the wresting team at his high school and that, “For the past week, one guy after another got this same thing.” VS are within normal limits and his mucous membranes are slightly dry. The most likely cause of Joseph's clinical condition is: A. Staphylococcal food poisoningB. Clostridium difficile (C. diff) enteritisC. Viral gastroenteritisD. Gastric ulcer Visit fhea.com to learn more!

This podcast will give you an approach to staphylococcal scalded skin syndrome (SSSS), a blistering skin infection that is seen mainly in infants and young children. The podcast was created by Jasmine Gill, a third year medical student at the University of Alberta, in collaboration with Dr. Melanie Lewis, a Professor and General Pediatrician from the Stollery Children's Hospital.

In this episode, we review the high-yield topic of Staphylococcal Scalded Skin Syndrome from the Dermatology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

 1:19 Labiotech.eu news2:32 Biomedical Research & Bio-Products12:15 Model N21:39 Institute of Clinical MedicineThis week our guests are Marit Inngjerdingen from the Institute of Clinical Medicine in Norway; Kyle Forcier, senior director of life sciences product marketing at Model N; and Dr. Andreas Roetzer, head of R&D for vaccines at Biomedical Research & Bio-Products.The next breakthrough in cancer treatment?In our body, we have an innate immune system and an immune system that is developed throughout life. Part of the innate immune system consists of so-called NK (natural killer) cells. This is a type of immune cell that specializes in killing cancer cells. These cells may be of great importance for cancer treatment in the future. NK cells kill cancer cells with the help of small “killer torpedoes,” or vesicles, that the NK cells secrete. Vesicles are small bubbles with a fatty wall of lipids and a space filled with toxic proteins. Researchers at the Institute of Clinical Medicine in Norway have recently discovered new things about these killer vesicles.“We have discovered that we can separate the killer torpedoes from other types of vesicles so that they form a kind of arsenal of weapons. Our research also shows that this type of vesicle is probably stored in a separate room inside the NK cell,” Miriam Aarsund Larsen said.Model N publishes revenue reportModel N, Inc. recently announced the results of its fifth annual State of Revenue Report. The report captures detailed data intended to help life sciences and high-tech industry executives grappling with how to grow company revenue and market share. Most executives named inflation as a significant headwind, with 84% calling it the single biggest impact on innovation.“Our findings show three main themes: Innovation collides with current market realities, innovation directly impacts revenue management, and the use of technology for revenue management is expanding,” said Suresh Kannan, chief product officer, Model N. “As organizations continue to navigate the current economic climate, the quality and reliability of technology solutions are more important than ever. These insights help us understand how to empower our customers to create and bring life-changing products to market.”Phase 2 study of breakthrough vaccine against toxic shock syndrome successfully completedThe first vaccine to potentially prevent Staphylococcal-induced toxic shock syndrome (TSS) has successfully completed a phase 2 study. TSS is a life-threatening condition caused by toxins that can lead to multiple organ failure and death.Nosocomial pathogen Methicillin-resistant Staphylococcus aureus (MRSA) bacteria are resistant to widely used antibiotics. Infections with MRSA are harder to treat and therapies are more expensive as the length of hospital stays is significantly prolonged. If the treatment does not lead to rapid clearance of the bacterial pathogen, dangerous symptoms such as septic or toxic shock can occur – a potentially life-threatening condition.Researchers at Biomedical Research & Bio-Products AG, under the direction of Martha Eibl, in cooperation with MedUni Vienna's Department of Clinical Pharmacology, conducted the study. The promising results showed the TSST-1 vaccine is safe and effective, with immunization lasting for at least two years. 

Livestock farmers listen up! Ever heard of the Staphylococcal skin disease in livestock. Food For Mzansi commercial journalists, Octavia Spandiel chats to Afrivets, Dr Didi Claassen to more on this disease, preventative measures, and general tips for farmers.

3.06 Staphylococcus Species Microbiology review for the USMLE Step 1 Exam Staphylococcus bacteria are gram-positive cocci that form clusters in the shape of grapes on a vine Three pathogenic species of staph: staph aureus, staph epidermidis, and staph saprophyticus Differentiation between species can be done using coagulase and novobiocin sensitivity tests Staph aureus is a major pathogen that causes many severe infections including toxic shock syndrome, septic arthritis, acute endocarditis, gastroenteritis, pneumonia, and staphylococcal scalded skin syndrome Toxic shock syndrome can be caused by tampons, soft tissue infections, post-surgical infections, and retained foreign bodies Staphylococcal scalded skin syndrome, or Ritter disease, is characterized by exfoliative damage to the skin and mainly affects newborns within 48 hours of birth Staph aureus can spread hematogenously and affect many parts of the body, particularly the heart and joints. Gastroenteritis caused by staph aureus is caused by consumption of exotoxins produced by the bacteria.

Contributor: Travis Barlock, MD Educational Pearls: Catheter related blood infections were thought to be caused by skin flora seeding the catheter. Thus, significant effort is applied to sterility and skin preparation.   However, studies have shown that bacteria growing on the tip of the catheter is not consistent with growth on cultures of skin.   Staphylococcus epidermidis is commonly found on cultures of catheter sites. It has also been found in the gut flora of >50% of ICU patients. Rates of catheter related blood infections have been decreased through oral decontamination and early feeding.  These findings suggest enteral bacterial translation as a major source of blood stream infection. References O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52(9):e162-e193. doi:10.1093/cid/cir257 von Eiff C, Becker K, Machka K, Stammer H, Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med. 2001;344(1):11-16. doi:10.1056/NEJM200101043440102 ALTEMEIER WA, HUMMEL RP, HILL EO. Staphylococcal enterocolitis following antibiotic therapy. Ann Surg. 1963;157(6):847-858. doi:10.1097/00000658-196306000-00003 Marshall JC, Christou NV, Horn R, Meakins JL. The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. Arch Surg. 1988;123(3):309-315. doi:10.1001/archsurg.1988.01400270043006 Mrozek N, Lautrette A, Aumeran C, et al. Bloodstream infection after positive catheter cultures: what are the risks in the intensive care unit when catheters are routinely cultured on removal?. Crit Care Med. 2011;39(6):1301-1305. doi:10.1097/CCM.0b013e3182120190 Atela I, Coll P, Rello J, et al. Serial surveillance cultures of skin and catheter hub specimens from critically ill patients with central venous catheters: molecular epidemiology of infection and implications for clinical management and research. J Clin Microbiol. 1997;35(7):1784-1790. doi:10.1128/jcm.35.7.1784-1790.1997 Tani T, Hanasawa K, Endo Y, et al. Bacterial translocation as a cause of septic shock in humans: a report of two cases. Surg Today. 1997;27(5):447-449. doi:10.1007/BF02385710   Summarized by Kirsten Hughes, MS4 | Edited by John Spartz, MS4 & Erik Verzemnieks, MD In an effort to promote diversity, equity, and inclusion in Emergency Medicine, The Emergency Medical Minute is proud to present our 2nd annual Diversity and Inclusion Award. We support increasing the representation of underrepresented groups in medicine and extend this award to individuals applying to emergency medicine residencies during the 2022-2023 cycle. For information on award eligibility and the application process, visit https://emergencymedicalminute.com/edi-award/ Donate to EMM today!

In this episode, we review the high-yield topic of Staphylococcal Scalded Skin Syndrome (SSSS) from the Dermatology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

Dr. Chambers, Professor of Medicine at the University of California, San Francisco, presents a state of the art lecture on current trends in the management of Staphylococcal bacteremia. Dr. Chambers begins by discussing risk factors leading to a poor outcome with Staphylococcus aureus bacteremia. He next discusses the role of Echocardiography (including 2D echo and TEE) in the diagnosis of endocarditis and when to use each modality in a given patient. Next, he contrasts the therapeutic management of both methicillin susceptible and methicillin resistant Staphylococcus aureus. Topics also discussed include the use of oral step down therapy in the treatment of endocarditis and bacteremia, the appropriate duration of treatment courses for bacteremia (both complicated and uncomplicated), and the use of combination antibiotic regimens for treating bacteremia infections.

This episode covers staphylococcal scalded skin syndrome (SSSS).Written notes can be found at https://zerotofinals.com/paediatrics/dermatology/ssss/ or in the dermatology section of the Zero to Finals paediatrics book.The audio in the episode was expertly edited by Harry Watchman.

Dr. Katzman reviews the importance of toxins in the manifestation of bacterial diseases. Bacterial toxins cause injury by producing tissue damage to the host during a bacterial infection. The different mechanisms by which bacterial toxins can produce injury are reviewed, including via intracellular and cell surface targets, membrane damage, superantigens, and involvement of the extracellular matrix. Dr. Katzman next reviews several well-known bacterial toxins, including Staphylococcal and Streptococcal toxins and Pseudomonas exotoxin A. Lastly, toxin therapies, such as toxoids and passive immunization are reviewed.

In this episode, host Beckie Mossor, RVT, connects with William Oldenhoff, DVM, DACVD, to discuss one of the most common dermatologic conditions in veterinary practice: Staphylococcus infections. Dr. Oldenhoff breaks down the bacteria that are typically involved in these infections, the associated clinical signs, and a few of the underlying causes. He also discusses the best approaches to treating staphylococcal infections and the continuing rise of drug resistance.Sponsor information:https://delmontlabs.com/treatment-with-staphage-lysate-spl/Contact us:Podcast@briefmedia.comWhere to find us:Cliniciansbrief.com/podcastsFacebook.com/clinciansbriefTwitter: @cliniciansbriefInstagram: @clinicians.briefThe Team:Beckie Mossor, RVT - HostAlexis Ussery - Producer & Digital Content CoordinatorRandall Stupka - Podcast Production & Sound EditingMichelle Munkres - Senior Director of Content

When you get a consult for concern of Stevens Johnson syndrome or TEN, you cannot get tunnel vision and have to keep a broad differential, which should include many of the toxin-mediated disorders we’ll discuss in today’s episode, including Staphylococcal scalded skin syndrome, toxic shock syndrome, Kawasaki disease, and scarlet fever.   Connect with us:         • … Continue reading "Ep24 VASC – Toxin-mediated rashes (SSSS, TSS, Kawasaki DZ, Scarlet Fever)"

This episode covers Tocmxic epidermal necrolysis, Steven Johnson Syndrome and Staphylococcal scalded skin syndrome

Resistance and virulence mechanisms are discussed.  Clinical presentations as well as the difference between colonization and infection are considered.Screening, prevention, and understanding Community Acquired MRSA vs Healthcare Acquired MRSA strains can be challenging, so practical information is presented for the common questions patients, families, and health care workers will often have.

Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.

Wed, 09 May 2012 14:32:39 GMT http://saveyourskin.ch/podcast/EN/2.2.7.SSSS.mp4 Prof. Dr. Dr. h. c. Günter Burg, MD Zürich & Prof. Dr. Walter Burgdorf, MD 2013-03-10T14:32:37Z Prof. Dr. Dr. h. c. Günter Burg, MD Zürich & Prof. Dr. Walter Burgdorf, MD no Staphylococcal scalde

Wed, 09 May 2012 14:32:39 GMT http://saveyourskin.ch/podcast/DE/2.2.7.SSSS.mp4 Prof. Dr. Dr. h. c. Günter Burg, MD Zürich 2013-03-10T14:32:37Z Prof. Dr. Dr. h. c. Günter Burg, MD Zürich no Staphylococcal scalde

Development of a biosensor for the simultaneous detection of microorganisms and toxins This project aimed at the development of a novel test system (parallel affinity sensor array, PASA) enabling the rapid, parallel and automated detection of microorganisms and toxins (Y. pestis, F. tularensis, C. burnetii, shigatoxins 1 und 2, Staphylococcal enterotoxin B und orthopoxvirus). For this purpose the classical sandwich-EIA principle was combined with the innovative microarray technology. The core of the biosensor is a planar biochip represented by a modified microscope slide on which the different tests run in parallel. The detection is enabled by specific antibodies attached to the slides surface by covalent or adsorptive binding. All further incubation steps are performed in a flow-through cell, reagents are automatically supplied by computer controlled pumps. With respect to the implementation of the detection methods in the PASA system each single-analyte assay was optimized by using classical EIA techniques and then adapted to a uniform test procedure. To enhance assay sensitivity the Biotin/ExtrAvidin, the Digoxigenin/anti-digoxigenin and partially fluorescence detection methods were checked. The most sensitive assays could be established by using detection antibodies labelled with digoxigenin. The detection limits of the optimized assays were in the range of 103 - 104 cfu/ml, microbial toxins could be detected at the pg-level. For transferring these optimized assays from microtiter plates to the biosensor platform a broad range of different biochip surfaces were tested. With some of the tested materials major problems encountered either due to inactivation of the antibodies during the immobilization on covalently binding solid phases or due to bleaching-out of antibody-coated adsorptive surfaces. The use of antibodies labelled with fluorochromes proved to be a failure. Two chemiluminescent microarray tests which complied with the basic requirements adherent to the establishment of an automated rapid detection method were further optimized and evaluated for robustness. Both assays enabled the reliable and reproducible detection of bacteria (105 – 107 cfu/ml) and purified toxins (lower ng-range) within 25 min. Thus, these microarrays rank among the most sensitive rapid tests described so far.