Podcasts about bmj open

Gambling Disorder (Gambling Addiction or Problem Gambling) explained, a very under-recognised condition. Includes the 9 core symptoms and diagnostic criteria, as well as treatment options. Consider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Gambling Disorder?0:38 Gambling Disorder Symptoms1:40 Gambling Disorder Diagnostic Criteria2:16 Gambling Disorder Risk Factors3:12 Gambling Disorder TreatmentReferencesAmerican Psychiatric Association Hector Colon-Rivera, M.D., CMRO, Kavita Fischer M.D., DFAPA (2024) - “What is Gambling Disorder?”. Available at https://www.psychiatry.org/patients-families/gambling-disorder/what-is-gambling-disorderMenchon JM, Mestre-Bach G, Steward T, Fernández-Aranda F, Jiménez-Murcia S. An overview of gambling disorder: from treatment approaches to risk factors. F1000Res. 2018 Apr 9;7:434. doi: 10.12688/f1000research.12784.1. PMID: 30090625; PMCID: PMC5893944. Available at https://pmc.ncbi.nlm.nih.gov/articles/PMC5893944/World Health Organisation (2024) - “Gambling”. Available at https://www.who.int/news-room/fact-sheets/detail/gamblingThomas SA, Merkouris SS, Browning CJ, Radermacher H, Feldman S, Enticott J, Jackson AC. The PROblem Gambling RESearch Study (PROGRESS) research protocol: a pragmatic randomised controlled trial of psychological interventions for problem gambling. BMJ Open. 2015 Nov 24;5(11):e009385. doi: 10.1136/bmjopen-2015-009385. PMID: 26603250; PMCID: PMC4663416. Available at https://pmc.ncbi.nlm.nih.gov/articles/PMC4663416/Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. 

Last episode we described the literature showing no survival benefit to patients with the AutoPulse device. Fear not, I wasn't ignoring the LUCAS, I just felt it deserved it's own episode. We'll cover the LINC and PARAMEDIC randomized controlled trials and the secondary analysis of LINC in shockable rhythms. I switched to a new production process using a new mic (Rode NT1) and started using ecamm to record. Yes, I know there is a bit of AV dysynchrony.. I'm working on it. I still have a lot to learn about ecamm but am optimistic about it. Citations on LUCAS device:1. Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, et al.: Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The LINC Randomized Trial. JAMA. 2014;January 1;311(1):53–61.2. Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther A-M, Woollard M, Carson A, et al.: Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. The Lancet. 2015;385(9972):947–55.3. Hardig BM, Lindgren E, Östlund O, Herlitz J, Karlsten R, Rubertsson S: Outcome among VF/VT patients in the LINC (LUCAS IN cardiac arrest) trial—A randomised, controlled trial. Resuscitation. 2017;June;115:155–62. Citations on Jeff's Tamiflu Rant1. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ: Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348:g2545.2. Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Onakpoya I, Heneghan CJ: Risk of bias in industry-funded oseltamivir trials: comparison of core reports versus full clinical study reports. BMJ Open. 2014;4(9):e005253.3. Jefferson T: The Tamiflu Story: Why We Need Access To All Data From Clinical Trials. Open Knowledge Foundation Blog. FAST25 | May 19-21, 2025 | Lexington, KY

En este podcast te quiero explicar el paso número uno que transformó mi relación con el móvil y cómo este simple cambio mejoró mi calidad de vida, productividad y sueño. También te explico por qué evitar el uso del móvil en las mañanas es clave para empezar tu día con enfoque y energía positiva.Descubre cómo implementé una rutina que eliminó mi adicción al móvil, los hábitos que fortalecen mi foco cognitivo y cómo puedes aplicar estos cambios en tu vida diaria. Si estás listo para recuperar el control sobre tu tiempo, este video es para ti.#adiccionalmovil #productividad #rutinamatutina #saludmental #calidaddelsueño #biohacking #gestiondeltiempo #PhilHugo #desarrollopersonal #hábitossaludablesEstudios:- Hysing, M., Pallesen, S., Stormark, K. M., Jakobsen, R., Lundervold, A. J., & Sivertsen, B. (2015). Sleep and use of electronic devices in adolescence: Results from a large population-based study. BMJ Open, 5(1), e006748. https://doi.org/10.1136/bmjopen-2014-006748- Ohayon, M. M., & Sagales, T. (2010). Prevalence of insomnia and sleep characteristics in the general population of Spain. Sleep Medicine, 11(10), 1010-1018. https://doi.org/10.1016/j.sleep.2010.02.018- Ohayon, M. M., & Bader, G. (2010). Prevalence and correlates of insomnia in the Swedish population aged 19-75 years. Sleep Medicine, 11(10), 980-986. https://doi.org/10.1016/j.sleep.2010.07.012

Drs. Nico Cortes-Penfield (@Cortes-Penfield), Kerry LaPlante (@Kerry_LaPlante), Jessica Seidelman (@JessieLSeidel) join Dr. Julie Ann Justo (@julie_justo) to discuss the pesky slime that is biofilm in periprosthetic joint infections. They review biofilm composition & development, have an honest discussion about whether antibiotics can ever really eradicate it, and provide updates on the promising non-pharmacologic strategies on the horizon (bacteriophages, electromagnetism, & more). Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp References Nixing the Nidus: Managing Retained Sources in Prosthetic Joint Infections. Breakpoints Podcast Episode #67. Society of Infectious Diseases Pharmacists. Dosing Consult: Rifampin Part 1. Breakpoints Podcast Episode #104. Society of Infectious Diseases Pharmacists. Review on Staphylococcal biofilm development: Schilcher K, Horswill AR. 2020 Aug 12;84(3):e00026-19. doi: 10.1128/MMBR.00026-19. PMID: 32792334. Antibiotics can fail to kill biofilm cells even if they penetrate the biofilm: Singh R, et al. Pathog Dis. 2016 Aug;74(6):ftw056. doi: 10.1093/femspd/ftw056. Epub 2016 Jul 7. PMID: 27402781. Subinhibitory antibiotic concentrations can promote biofilm formation: Schilcher K, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5957-67. doi: 10.1128/AAC.00463-16. PMID: 27458233. Clinical and genetic risk factors for biofilm-forming Staphylococcus aureus: Luther MK, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02252-17. doi: 10.1128/AAC.02252-17. PMID: 29530854. Meta-analysis showing poor clinical outcomes with debridement, antibiotics, and implant retention (DAIR): Kunutsor SK, et al. J Infect. 2018 Dec;77(6):479-488. doi: 10.1016/j.jinf.2018.08.017. PMID: 30205122. Thieme L, et al. MBEC versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology. Biol Proced Online 21, 18 (2019). https://doi.org/10.1186/s12575-019-0106-0. Ongoing trial investigating use of MBEC in the treatment of PJIs: Tillander JAN, et al. BMJ Open. 2022 Sep 15;12(9):e058168. doi: 10.1136/bmjopen-2021-058168. PMID: 36109038. Maale, G. Complete eradication of biofilm using low frequency electromagnetic force (EMF) and antibiotics at MIC. 34th Annual Meeting Musculoskeletal Infection Society. 2024 Aug. Abstract 1232 (see full program). Meta-analysis on bacteriophages for biofilm: Kovacs CJ, et al. Mil Med. 2024 May 18;189(5-6):e1294-e1302. doi: 10.1093/milmed/usad385. PMID: 37847552. Berking BB, et al. Biofilm disruption from within: light-activated molecular drill-functionalized polymersomes bridge the gap between membrane damage and quorum sensing-mediated cell death. ACS Biomater Sci Eng. 2024 Sep 9;10(9):5881-5891. doi: 10.1021/acsbiomaterials.4c01177. PMID: 39176452. Aboelnaga N, et al. Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances. Cell Commun Signal. 2024 Mar 22;22(1):188. doi: 10.1186/s12964-024-01511-2. PMID: 38519959. Conway J, et al. Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0065524. doi: 10.1128/aac.00655-24. PMID: 39012102. Mulpur P, et al. Efficacy of intrawound vancomycin in prevention of periprosthetic joint infection after primary total knee arthroplasty: a prospective double-blinded randomized control trial. J Arthroplasty. 2024 Jun;39(6):1569-1576. doi: 10.1016/j.arth.2024.01.003. PMID: 38749600. Dong Y, et al. Synergy of ultrasound microbubbles and vancomycin against Staphylococcus epidermidis biofilm. J Antimicrob Chemother. 2013 Apr;68(4):816-26. doi: 10.1093/jac/dks490. PMID: 23248238. Miltenberg B, et al. Intraosseous Regional Administration of Antibiotic Prophylaxis for Total Knee Arthroplasty: A Systematic Review. J Arthroplasty. 2023 Apr;38(4):769-774. doi: 10.1016/j.arth.2022.10.023. PMID: 36280158. Viswanathan VK, et al. Intraosseous regional antibiotic prophylaxis in total joint arthroplasty (TJA): Systematic review and meta-analysis. J Clin Orthop Trauma. 2024 Oct 3;57:102553. doi: 10.1016/j.jcot.2024.102553. PMID: 39435324. SOLARIO trial: Dudareva M, et al. The European Bone and Joint Infection Society Meeting, 2024 Sept. SOLARIO trial press release from BoneSupportTM. 2024 Oct 3. Fehring TK, et al. Does treatment at a specialized prosthetic joint infection center improve the rate of reimplantation. J Arthroplasty. 2023 Jun;38(6S):S314-7. PMID 37004968. ROADMAP trial website. 2024.

Egal zu welchem Anlass, in Deutschland wird gerne getrunken. Obwohl der Konsum seit Jahren langsam sinkt, liegen wir im internationalen Vergleich immer noch weit vorn. Schätzungen gehen davon aus, dass jährlich mehr als 40.000 Menschen in Deutschland an den Folgen ihres Alkoholkonsums vorzeitig sterben. Und dennoch gilt Alkoholtrinken immer noch als normal. Warum können - oder wollen - wir nicht auf diese Droge verzichten? Es nur mit dem Rausch, mit der kleinen Flucht aus dem Alltag zu erklären, wäre zu einfach.  Autorin Yasmin Appelhans ist dem Alkoholkonsum wissenschaftlich auf den Grund gegangen und hat dafür auch in der Evolutionsgeschichte gewühlt. Im Gespräch mit Host Lucie Kluth erzählt sie von ihren spannenden Erkenntnissen - unter anderem, warum unser Körper Alkohol relativ gut verarbeiten kann, was die forschungsrelevante "Drunken Monkey Hypothesis" damit zu tun hat und warum gerade Soziale Medien mitverantwortlich dafür sind, dass viele junge Menschen ihren Alkoholkonsum hinterfragen. DIE HINTERGRUNDINFORMATIONEN 1. Dudley R. Evolutionary Origins of Human Alcoholism in Primate Frugivory. The Quarterly Review of Biology. 2000;75(1): 3–15. https://doi.org/10.1086/393255. 2. Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, et al. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences. 2015;112(2): 458–463. https://doi.org/10.1073/pnas.1404167111. 3. Bowland AC, Melin AD, Hosken DJ, Hockings KJ, Carrigan MA. The evolutionary ecology of ethanol. Trends in Ecology & Evolution. 2024;0(0). https://doi.org/10.1016/j.tree.2024.09.005. 4. Dudley R, Maro A. Human Evolution and Dietary Ethanol. Nutrients. 2021;13(7): 2419. https://doi.org/10.3390/nu13072419. 5. Dashko S, Zhou N, Compagno C, Piškur J. Why, when, and how did yeast evolve alcoholic fermentation? Fems Yeast Research. 2014;14(6): 826–832. https://doi.org/10.1111/1567-1364.12161. 6. Milan NF, Kacsoh BZ, Schlenke TA. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology. 2012;22(6): 488–493. https://doi.org/10.1016/j.cub.2012.01.045. 7. Heinz A, Daedelow LS. Alkohol als Kulturgut – eine historisch-anthropologische und therapeutische Perspektive auf Alkoholkonsum und seine soziale Rolle in westlichen Gesellschaften. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2021;64(6): 646–651. https://doi.org/10.1007/s00103-021-03327-8. 8. Cooke R. The Palgrave handbook of psychological perspectives on alcohol consumption. Cham, Switzerland: Springer; 2021. 9. Alkoholkonsum in Deutschland: https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/a/alkohol.html [Accessed 9th December 2024]. 10. Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. The Lancet. 2010;376(9752): 1558–1565. https://doi.org/10.1016/S0140-6736(10)61462-6. 11. Mamluk L, Edwards HB, Savović J, Leach V, Jones T, Moore THM, et al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe' levels of alcohol during pregnancy? A systematic review and meta-analyses. BMJ Open. 2017;7(7): e015410. https://doi.org/10.1136/bmjopen-2016-015410. 12. Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. The Lancet. 2019;393(10190): 2493–2502. https://doi.org/10.1016/S0140-6736(18)32744-2. 13. Kilian C, Manthey J, Rehm J, Kraus L. Alkoholpolitik in Deutschland: Verpasste Chancen zur Senkung der Krankheitslast. SUCHT. 2023;69(4): 163–171. https://doi.org/10.1024/0939-5911/a000823. 14. Binder A, Kilian C, Hanke S, Banabak M, Berkenhoff C, Petersen KU, et al. Stigma and self-stigma among women within the context of the german “zero alcohol during pregnancy” recommendation: A qualitative analysis of online forums and blogs. International Journal of Drug Policy. 2024;124: 104331. https://doi.org/10.1016/j.drugpo.2024.104331. 15. Stockwell T, Zhao J, Clay J, Levesque C, Sanger N, Sherk A, et al. Why Do Only Some Cohort Studies Find Health Benefits From Low-Volume Alcohol Use? A Systematic Review and Meta-Analysis of Study Characteristics That May Bias Mortality Risk Estimates. Journal of Studies on Alcohol and Drugs. 2024;85(4): 441–452. https://doi.org/10.15288/jsad.23-00283. 16. Cook M, Critchlow N, O'Donnell R, MacLean S. Alcohol's contribution to climate change and other environmental degradation: a call for research. Health Promotion International. 2024;39(1): daae004. https://doi.org/10.1093/heapro/daae004. 17. 3.7 Genetik der Alkoholabhängigkeit.. 2011th ed. Alkohol und Tabak. Thieme Verlag; 2011. https://doi.org/10.1055/b-0034-40723. [Accessed 21st December 2024]. 18. Hakulinen C, Elovainio M, Batty GD, Virtanen M, Kivimäki M, Jokela M. Personality and Alcohol Consumption: Pooled Analysis of 72,949 Adults from Eight Cohort Studies. Drug and alcohol dependence. 2015;151: 110–114. https://doi.org/10.1016/j.drugalcdep.2015.03.008. 19. Heinz A, Gül Halil M, Gutwinski S, Beck A, Liu S. ICD-11: Änderungen der diagnostischen Kriterien der Substanzabhängigkeit. Der Nervenarzt. 2022;93(1): 51–58. https://doi.org/10.1007/s00115-021-01071-7. 20. Alkoholberatung: Alkohol? Kenn dein Limit. https://www.kenn-dein-limit.de/alkoholberatung/ [Accessed 21st December 2024].

Egal zu welchem Anlass, in Deutschland wird gerne getrunken. Obwohl der Konsum seit Jahren langsam sinkt, liegen wir im internationalen Vergleich immer noch weit vorn. Schätzungen gehen davon aus, dass jährlich mehr als 40.000 Menschen in Deutschland an den Folgen ihres Alkoholkonsums vorzeitig sterben. Und dennoch gilt Alkoholtrinken immer noch als normal. Warum können - oder wollen - wir nicht auf diese Droge verzichten? Es nur mit dem Rausch, mit der kleinen Flucht aus dem Alltag zu erklären, wäre zu einfach.  Autorin Yasmin Appelhans ist dem Alkoholkonsum wissenschaftlich auf den Grund gegangen und hat dafür auch in der Evolutionsgeschichte gewühlt. Im Gespräch mit Host Lucie Kluth erzählt sie von ihren spannenden Erkenntnissen - unter anderem, warum unser Körper Alkohol relativ gut verarbeiten kann, was die forschungsrelevante "Drunken Monkey Hypothesis" damit zu tun hat und warum gerade Soziale Medien mitverantwortlich dafür sind, dass viele junge Menschen ihren Alkoholkonsum hinterfragen. DIE HINTERGRUNDINFORMATIONEN 1. Dudley R. Evolutionary Origins of Human Alcoholism in Primate Frugivory. The Quarterly Review of Biology. 2000;75(1): 3–15. https://doi.org/10.1086/393255. 2. Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, et al. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences. 2015;112(2): 458–463. https://doi.org/10.1073/pnas.1404167111. 3. Bowland AC, Melin AD, Hosken DJ, Hockings KJ, Carrigan MA. The evolutionary ecology of ethanol. Trends in Ecology & Evolution. 2024;0(0). https://doi.org/10.1016/j.tree.2024.09.005. 4. Dudley R, Maro A. Human Evolution and Dietary Ethanol. Nutrients. 2021;13(7): 2419. https://doi.org/10.3390/nu13072419. 5. Dashko S, Zhou N, Compagno C, Piškur J. Why, when, and how did yeast evolve alcoholic fermentation? Fems Yeast Research. 2014;14(6): 826–832. https://doi.org/10.1111/1567-1364.12161. 6. Milan NF, Kacsoh BZ, Schlenke TA. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology. 2012;22(6): 488–493. https://doi.org/10.1016/j.cub.2012.01.045. 7. Heinz A, Daedelow LS. Alkohol als Kulturgut – eine historisch-anthropologische und therapeutische Perspektive auf Alkoholkonsum und seine soziale Rolle in westlichen Gesellschaften. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2021;64(6): 646–651. https://doi.org/10.1007/s00103-021-03327-8. 8. Cooke R. The Palgrave handbook of psychological perspectives on alcohol consumption. Cham, Switzerland: Springer; 2021. 9. Alkoholkonsum in Deutschland: https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/a/alkohol.html [Accessed 9th December 2024]. 10. Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. The Lancet. 2010;376(9752): 1558–1565. https://doi.org/10.1016/S0140-6736(10)61462-6. 11. Mamluk L, Edwards HB, Savović J, Leach V, Jones T, Moore THM, et al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe' levels of alcohol during pregnancy? A systematic review and meta-analyses. BMJ Open. 2017;7(7): e015410. https://doi.org/10.1136/bmjopen-2016-015410. 12. Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. The Lancet. 2019;393(10190): 2493–2502. https://doi.org/10.1016/S0140-6736(18)32744-2. 13. Kilian C, Manthey J, Rehm J, Kraus L. Alkoholpolitik in Deutschland: Verpasste Chancen zur Senkung der Krankheitslast. SUCHT. 2023;69(4): 163–171. https://doi.org/10.1024/0939-5911/a000823. 14. Binder A, Kilian C, Hanke S, Banabak M, Berkenhoff C, Petersen KU, et al. Stigma and self-stigma among women within the context of the german “zero alcohol during pregnancy” recommendation: A qualitative analysis of online forums and blogs. International Journal of Drug Policy. 2024;124: 104331. https://doi.org/10.1016/j.drugpo.2024.104331. 15. Stockwell T, Zhao J, Clay J, Levesque C, Sanger N, Sherk A, et al. Why Do Only Some Cohort Studies Find Health Benefits From Low-Volume Alcohol Use? A Systematic Review and Meta-Analysis of Study Characteristics That May Bias Mortality Risk Estimates. Journal of Studies on Alcohol and Drugs. 2024;85(4): 441–452. https://doi.org/10.15288/jsad.23-00283. 16. Cook M, Critchlow N, O'Donnell R, MacLean S. Alcohol's contribution to climate change and other environmental degradation: a call for research. Health Promotion International. 2024;39(1): daae004. https://doi.org/10.1093/heapro/daae004. 17. 3.7 Genetik der Alkoholabhängigkeit.. 2011th ed. Alkohol und Tabak. Thieme Verlag; 2011. https://doi.org/10.1055/b-0034-40723. [Accessed 21st December 2024]. 18. Hakulinen C, Elovainio M, Batty GD, Virtanen M, Kivimäki M, Jokela M. Personality and Alcohol Consumption: Pooled Analysis of 72,949 Adults from Eight Cohort Studies. Drug and alcohol dependence. 2015;151: 110–114. https://doi.org/10.1016/j.drugalcdep.2015.03.008. 19. Heinz A, Gül Halil M, Gutwinski S, Beck A, Liu S. ICD-11: Änderungen der diagnostischen Kriterien der Substanzabhängigkeit. Der Nervenarzt. 2022;93(1): 51–58. https://doi.org/10.1007/s00115-021-01071-7. 20. Alkoholberatung: Alkohol? Kenn dein Limit. https://www.kenn-dein-limit.de/alkoholberatung/ [Accessed 21st December 2024].

In this episode of Brown Women Health, we dive into two fascinating papers that highlight critical health issues for South Asian women and infants. First, we discuss the Nurture Early for Optimal Nutrition (NEON) pilot study, which explores the impact of participatory learning and action women's groups on improving infant feeding practices in South Asia. Next, we explore a qualitative synthesis of South Asian women's perspectives on maternity care services, shedding light on their unique experiences and challenges in accessing care. Join us as we break down these insightful studies and discuss their implications for improving maternal and infant health outcomes in South Asian communities. Papers Discussed: Nurture Early for Optimal Nutrition (NEON) Participatory Learning and Action Women's Groups to Improve Infant Feeding and Practices in South Asian Infants: Pilot Randomised Trial Study ProtocolManikam L, Allaham S, Patil P, et al. BMJ Open 2023;13:e063885.Read the paper here Exploring South Asian Women's Perspectives and Experiences of Maternity Care Services: A Qualitative Evidence SynthesisNagesh N, Ip CHL, Li J, et al. Women Birth 2024;37(2):259-277.Read the paper here Special Offer: This episode is brought to you by Magic Mind! If you're looking to improve focus and reduce stress, try Magic Mind and use our code BWHPOD20 for up to 48% off a subscription or 20% off a one-time purchase at magicmind.com/bwhpod --- Support this podcast: https://podcasters.spotify.com/pod/show/brownwomenhealth/support

In today's episode, I will address an important issue impacting workplaces worldwide: workplace depression. This topic affects everyone directly or indirectly through colleagues, friends, or family members. I will discuss how depression manifests in the workplace, the risk factors,  warning signs, and strategies for managing depression at work. I will also share how our mindset about stress can significantly influence our mental health outcomes.ReferencesDeady, M., Collins, D. A. J., Johnston, D. A., Glozier, N., Calvo, R. A., Christensen, H., & Harvey, S. B. (2022). A pilot evaluation of a smartphone application for workplace depression. International Journal of Environmental Research and Public Health, 17(6753), 1-14. https://doi.org/10.3390/ijerph17186753Greiner, B. A., & Arensman, E. (2022). The role of work in suicidal behavior - uncovering priorities for research and prevention. Scandinavian Journal of Work, Environment & Health, 48(6), 419–424. https://doi.org/10.5271/sjweh.4051 Huebschmann, N. A., & Sheets, E. S. (2020). The right mindset: Stress mindset moderates the association between perceived stress and depressive symptoms. Anxiety, Stress, & Coping, 1-8. https://doi.org/10.1080/10615806.2020.1736900LaMontagne, A. D., Åberg, M., Blomqvist, S., Glozier, N., Greiner, B. A., Gullestrup, J., Harvey, S. B., Kyron, M. J., Madsen, I. E. H., Hanson, L. M., Maheen, H., Mustard, C., Niedhammer, I., Rugulies, R., Smith, P. M., Taouk, Y., Waters, S., Witt, K., & King, T. L. (2024). Work-related suicide: Evolving understandings of etiology & intervention. American Journal of Industrial medicine, 67(8), 679–695. https://doi.org/10.1002/ajim.23624 Moon, J. Y., Choi, T. Y., Won, E. S., Won, G. H., Kim, S. Y., Lee, H. J., & Yoon, S. (2022). The relationship between workplace burnout and male depression symptom assessed by the Korean version of the Gotland Male Depression Scale. American Journal of Men's Health, 16(5), 1-13. https://doi.org/10.1177/15579883221123930Zadow, A. J., Dollard, M. F., Dormann, C., & Landsbergis, P. (2021). Predicting new major depression symptoms from long working hours, psychosocial safety climate and work engagement: A population‐based cohort study. BMJ Open, 11(6), e044133. https://doi.org/10.1136/bmjopen-2020-044133https://www.virtual-college.co.uk/resources/uk-suicides-could-be-work-related-research-suggestshttps://ahc.leeds.ac.uk/download/downloads/id/678/work-related_suicide_a_qualitative_analysis_of_recent_cases_with_recommendations_for_reform.pdfhttps://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/articles/suicidebyoccupation/england2011to2015

Il verde, inteso come alberi e parchi, e blu, laghetti e ruscelli, fanno bene alla nostra salute. A dirlo una revisione delle ricerche disponibili sull’argomento, pubblicata sulla rivista BMJ Open che commentiamo a Obiettivo Salute con il prof. Marino Bonaiuto, Professore ordinario in Psicologia Sociale della Sapienza di Roma.

Références : Goldberg RM, Mabee J, Chan L et coll. Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population. Am J Emerg Med 1996;14(5):447-50. Parcours de Katherine Desforges en Australie : https://www.apesquebec.org/actualites/deprescription-et-transfert-dinformations-dans-le-parcours-de-soins-des-aines-avec-0 Brochures pour patients du Réseau canadien pour l'usage approprié des médicaments et la déprescription : https://www.reseaudeprescription.ca/ressources-patients Coe A, Kaylor-Hughes C, Fletcher S et coll. Deprescribing intervention activities mapped to guiding principles for use in general practice: a scoping review. BMJ Open 2021;11(9):e052547. Panel d'experts du 2023 AGS Beers Criteria Update. AGS 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2023;71(1):2052-81.

Welcome to Episode 37 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 37 of “The 2 View” – Pitfalls in Managing Pain in the ED with Sergey M. Motov, MD, FAAEM. Segment 1 Bachhuber MA, Hennessy S, Cunningham CO, Starrels JL. Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013. Am J Public Health. 2016;106(4):686-688. doi:10.2105/AJPH.2016.303061. https://pubmed.ncbi.nlm.nih.gov/26890165/ Bijur PE, Kenny MK, Gallagher EJ. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med. 2005;46(4):362-367. doi:10.1016/j.annemergmed.2005.03.010. https://pubmed.ncbi.nlm.nih.gov/16187470/ Evoy KE, Covvey JR, Peckham AM, Ochs L, Hultgren KE. Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS). Res Social Adm Pharm. 2019;15(8):953-958. doi:10.1016/j.sapharm.2018.06.018. https://pubmed.ncbi.nlm.nih.gov/31303196/ Kim HS, McCarthy DM, Hoppe JA, Mark Courtney D, Lambert BL. Emergency Department Provider Perspectives on Benzodiazepine-Opioid Coprescribing: A Qualitative Study. Acad Emerg Med. 2018;25(1):15-24. doi:10.1111/acem.13273. https://pubmed.ncbi.nlm.nih.gov/28791786/ Li Y, Delcher C, Wei YJ, et al. Risk of Opioid Overdose Associated With Concomitant Use of Opioids and Skeletal Muscle Relaxants: A Population-Based Cohort Study. Clin Pharmacol Ther. 2020;108(1):81-89. doi:10.1002/cpt.1807. https://pubmed.ncbi.nlm.nih.gov/32022906/ Peckham AM, Evoy KE, Covvey JR, Ochs L, Fairman KA, Sclar DA. Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population. Pharmacotherapy. 2018;38(4):436-443. doi:10.1002/phar.2096. https://pubmed.ncbi.nlm.nih.gov/29484686/ Smith RV, Havens JR, Walsh SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction. 2016;111(7):1160-1174. doi:10.1111/add.13324. https://pubmed.ncbi.nlm.nih.gov/27265421/ Suvada K, Zimmer A, Soodalter J, Malik JS, Kavalieratos D, Ali MK. Coprescribing of opioids and high-risk medications in the USA: a cross-sectional study with data from national ambulatory and emergency department settings. BMJ Open. 2022;12(6):e057588. Published 2022 Jun 16. doi:10.1136/bmjopen-2021-057588. https://pubmed.ncbi.nlm.nih.gov/35710252/ Segment 2 Caplan M, Friedman BW, Siebert J, et al. Use of clinical phenotypes to characterize emergency department patients administered intravenous opioids for acute pain. Clin Exp Emerg Med. 2023;10(3):327-332. doi:10.15441/ceem.23.018. https://pubmed.ncbi.nlm.nih.gov/37092185/ Connors NJ, Mazer-Amirshahi M, Motov S, Kim HK. Relative addictive potential of opioid analgesic agents. Pain Manag. 2021;11(2):201-215. doi:10.2217/pmt-2020-0048. https://pubmed.ncbi.nlm.nih.gov/33300384/ Fassassi C, Dove D, Davis A, et al. Analgesic efficacy of morphine sulfate immediate release vs. oxycodone/acetaminophen for acute pain in the emergency department. Am J Emerg Med. 2021;46:579-584. doi:10.1016/j.ajem.2020.11.034. https://pubmed.ncbi.nlm.nih.gov/33341323/ Irizarry E, Cho R, Williams A, et al. Frequency of Persistent Opioid Use 6 Months After Exposure to IV Opioids in the Emergency Department: A Prospective Cohort Study. J Emerg Med. Published online March 14, 2024. doi:10.1016/j.jemermed.2024.03.018. https://pubmed.ncbi.nlm.nih.gov/38821847/ Sapkota A, Takematsu M, Adewunmi V, Gupta C, Williams AR, Friedman BW. Oxycodone induced euphoria in ED patients with acute musculoskeletal pain. A secondary analysis of data from a randomized trial. Am J Emerg Med. 2022;53:240-244. doi:10.1016/j.ajem.2022.01.016. https://pubmed.ncbi.nlm.nih.gov/35085877/ Wightman R, Perrone J, Portelli I, Nelson L. Likeability and abuse liability of commonly prescribed opioids. J Med Toxicol. 2012;8(4):335-340. doi:10.1007/s13181-012-0263-x. https://pubmed.ncbi.nlm.nih.gov/22992943/ Segment 3 Anshus AJ, Oswald J. Erector spinae plane block: a new option for managing acute axial low back pain in the emergency department. Pain Manag. 2021;11(6):631-637. doi:10.2217/pmt-2021-0004. https://pubmed.ncbi.nlm.nih.gov/34102865/ Chauhan G, Burke H, Srinivasan SK, Upadhyay A. Ultrasound-Guided Erector Spinae Block for Refractory Abdominal Pain Due to Acute on Chronic Pancreatitis. Cureus. 2022;14(11):e31817. Published 2022 Nov 23. doi:10.7759/cureus.31817. https://pubmed.ncbi.nlm.nih.gov/36579238/ Dove D, Fassassi C, Davis A, et al. Comparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind Clinical Trial. Ann Emerg Med. 2021;78(6):779-787. doi:10.1016/j.annemergmed.2021.04.031. https://pubmed.ncbi.nlm.nih.gov/34226073/ Elkoundi A, Eloukkal Z, Bensghir M, Belyamani L, Lalaoui SJ. Erector Spinae Plane Block for Hyperalgesic Acute Pancreatitis. Pain Med. 2019;20(5):1055-1056. doi:10.1093/pm/pny232. https://pubmed.ncbi.nlm.nih.gov/30476275/ Finneran Iv JJ, Gabriel RA, Swisher MW, Berndtson AE, Godat LN, Costantini TW, Ilfeld BM. Ultrasound-guided percutaneous intercostal nerve cryoneurolysis for analgesia following traumatic rib fracture -a case series. Korean J Anesthesiol. 2020 Oct;73(5):455-459. doi: 10.4097/kja.19395. Epub 2019 Nov 5. PMID: 31684715; PMCID: PMC7533180. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533180/ Finneran JJ, Swisher MW, Gabriel RA, et al. Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. J Burn Care Res. 2020;41(1):224-227. doi:10.1093/jbcr/irz192. https://pubmed.ncbi.nlm.nih.gov/31714578/ Gabriel RA, Finneran JJ, Asokan D, Trescot AM, Sandhu NS, Ilfeld BM. Ultrasound-Guided Percutaneous Cryoneurolysis for Acute Pain Management: A Case Report. A A Case Rep. 2017;9(5):129-132. doi:10.1213/XAA.0000000000000546. https://pubmed.ncbi.nlm.nih.gov/28509777/ Herring AA, Stone MB, Nagdev AD. Ultrasound-guided abdominal wall nerve blocks in the ED. Am J Emerg Med. 2012;30(5):759-764. doi:10.1016/j.ajem.2011.03.008. https://pubmed.ncbi.nlm.nih.gov/21570238/ Kampan S, Thong-On K, Sri-On J. A non-inferiority randomized controlled trial comparing nebulized ketamine to intravenous morphine for older adults in the emergency department with acute musculoskeletal pain. Age Ageing. 2024;53(1):afad255. doi:10.1093/ageing/afad255. https://pubmed.ncbi.nlm.nih.gov/38251742/ Mahmoud S, Miraflor E, Martin D, Mantuani D, Luftig J, Nagdev AD. Ultrasound-guided transverse abdominis plane block for ED appendicitis pain control. Am J Emerg Med. 2019;37(4):740-743. doi:10.1016/j.ajem.2019.01.024. https://pubmed.ncbi.nlm.nih.gov/30718116/ McCahill RJ, Nagle C, Clarke P. Use of Virtual Reality for minor procedures in the Emergency Department: A scoping review. Australas Emerg Care. 2021;24(3):174-178. doi:10.1016/j.auec.2020.06.006. https://pubmed.ncbi.nlm.nih.gov/32718907/ Nguyen T, Mai M, Choudhary A, et al. Comparison of Nebulized Ketamine to Intravenous Subdissociative Dose Ketamine for Treating Acute Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind, Double-Dummy Controlled Trial. Ann Emerg Med. Published online May 2, 2024. doi:10.1016/j.annemergmed.2024.03.024. https://pubmed.ncbi.nlm.nih.gov/38703175/ Sikka N, Shu L, Ritchie B, Amdur RL, Pourmand A. Virtual Reality-Assisted Pain, Anxiety, and Anger Management in the Emergency Department. Telemed J E Health. 2019;25(12):1207-1215. doi:10.1089/tmj.2018.0273. https://pubmed.ncbi.nlm.nih.gov/30785860/ Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Training as imagined?, sim for faster stroke treatment, simulation after key events, Implementing TALK for clinical debriefing.  Another great month on Simulcast.  The articles: -  Kerins, J., Ralston, K., Stirling, S.A. et al. Training as imagined? A critical realist analysis of Scotland's internal medicine simulation programme. Adv Simul 9, 27 (2024)  Ajmi SC, Kurz M, Lindner TW, et al. Does clinical experience influence the effects of team simulation training in stroke thrombolysis? A prospective cohort study. BMJ Open 2024;14:e086413  Diaz-Navarro, C., Jones, B., Pugh, G. et al. Improving quality through simulation; developing guidance to design simulation interventions following key events in healthcare. Adv Simul 9, 30 (2024).  Diaz-Navarro C, Enjo-Perez I, Leon-Castelao E, Hadfield A, Nicolas-Arfelis JM, Castro-Rebollo P. Implementation of the TALK© clinical self-debriefing tool in operating theatres: a single-centre interventional study. Br J Anaesth. 2024 Jul 29:S0007-0912(24)00413-6.    And also mentioned on the podcast   The Self Development Module on ‘Introduction to Quality Improvement'  Happy listening!    And… Date Claimers    The Victorian Translational SIMposium  6th September, Melbourne . Details and registration here     Simulation Reconnect is on again   Bond University, Wednesday 27th November. Registration here  

Cost-effectiveness of strength exercise or aerobic exercise compared with usual care for patients with knee osteoarthritis: secondary results from a multiarm randomised controlled trial in Norway Killingmo RM, Øiestad BE, Risberg MA, et al. BMJ Open. 2024;14(5):e079704. doi:10.1136/bmjopen-2023-079704 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Remember when they were coming to take your gas stove away? Every so often a study about the effects of air pollution on health goes viral, and we're reminded again that seemingly innocuous objects—like your kitchen cooker—could be bad for us in unexpected ways. How bad is air pollution? And is it getting any better?In this episode of The Studies Show, Tom and Stuart look into the science of air pollution, trying to separate correlation from causality, and working out what scientists mean when they say that deaths are “attributable” to something (it's more complicated than you think!).The Studies Show is brought to you by Works in Progress magazine. We usually mention their long-form pieces at worksinprogress.co, but they also have a Substack newsletter at worksinprogress.news with shorter articles on the same topics. We commend it to you, and thank Works in Progress for sponsoring the podcast.Show notes* Recent news about “Ella's Law” in the UK* Tom's 2019 Unherd article on air pollution* “Death risk from London's toxic air sees ‘utterly horrifying' rise for second year running”* The Our World In Data “Deaths by Risk Factor” graph* 2024 BMJ Open article about the health risks of coal power stations* Dynomight's long article on air quality* The 1952 “Great Smog of London”* More useful Our World In Data articles:* An explainer on “attributable fractions” and summing up multiple risk factors* On indoor air pollution* Deaths from outdoor pollution* Death rate from outdoor pollution* Deaths from outdoor pollution vs. GDP per capita* The WHO calls indoor air pollution “the world's single largest environmental health risk”* More on attributable fractions, with some examples* Example of an experimental study on the effects of air pollution* The article that sparked the Great Cooker Controversy of 2023* Example of the media coverage at the time* Biden forced to rule out a ban on gas cookers* Recent story on how there's “no safe level” of PM2.5* Based on this 2024 paper in the BMJ* How policy interventions can reduce (and have reduced) air pollution* London report on the effect of ULEZCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

Today we provide you with an update on the sexually transmitted infection: Trichomonas vaginalis, a protozoan which infects the vagina, urethra and paraurethral glands. It is an uncommon cause of vaginal discharge and penile urethritis and can persist for a long time if left untreated. Up to 50% of people with vaginal infections and especially people with urethral infections remain asymptomatic. Persistent trichomonas infection has been associated with facilitating the transmission of human immunodeficiency virus (HIV) and adverse poor reproductive health outcomes. Dr Christina Munzy, Professor in Infectious Diseases at University of Alabama, Birmingham, USA, will present on published clinical trial data on novel treatment against trichomoniasis. Relevant publications: Van Gerwen OT, Aaron KJ, Schroeder J, et al. Spontaneous resolution of Trichomonas vaginalis infection in men. Sexually Transmitted Infections. Published Online First: 27 June 2024. Muzny CA, Van Gerwen OT, Kaufman G, Chavoustie S. Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data. BMJ Open. 2023;13:e072071 Kissinger PJ, Gaydos CA, Seña AC, McClelland RS, Soper, Secor WE, Legendre D, Workowski KA, Muzny CA, Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines, Clinical Infectious Diseases, Clinical Infectious Diseases, Volume 74, Issue Supplement_2, 15 April 2022 Howe K and Kissinger PJ. Single-dose compared with multidose metronidazole for the treatment of trichomoniasis in women: a meta-analysis. Sex Transm Dis 2017; 44: 29–34. Kissinger P, Muzny CA, Mena LA, et al. Single-dose versus 7- day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial. Lancet Infect Dis 2018; 18: 1251–1259. Sherrard J, Pitt R, Hobbs KR, Maynard M, Cochrane E, Wilson J, Tipple C. British Association for Sexual Health and HIV (BASHH) United Kingdom national guideline on the management of Trichomonas vaginalis 2021. Int J STD AIDS. 2022 Jul;33(8):740-750. STI Guidelines Australia - Trichomoniasis Host: Dr Fabiola Martin, STI BMJ Podcast editor, a Sexual Health, HIV and HTLV Specialist, Canberra & University of Queensland, Brisbane, Australia Guest: Dr Christina Munzy, Professor in Infectious Diseases at University of Alabama, Birmingham, USA

From time to time we rebroadcast popular episodes from our past catalogue. This week we bring you an episode from season 4, where Gaylea Fritsch, Vic Branch Professional Education committee member, chats with Chris Payten, Advanced Speech Pathologist at Gold Coast Hospital and PhD candidate at the University of Sydney. Chris explores his current PhD research in the area of voice disorder classification and implementing a primary telehealth assessment model for voice disorders. Resources:  NAIDOC Week- https://www.naidoc.org.au/ NAIDOC Week event finder- https://www.naidoc.org.au/local-events/local-naidoc-week-events New resources from Chris: Payten.C., et al. Evidenced Based Framework for Voice Disorder Classification- https://ars.els-cdn.com/content/image/1-s2.0-S089219972200039X-mmc1_lrg.jpg Resources from original broadcast: Chris's telehealth study protocol can be accessed here: Payten CL, Nguyen DD, Novakovic D, O'Neill J, Chacon A, Weir KA, and Madill CJ. Telehealth voice assessment by speech language pathologists during a global pandemic using principles of a primary contact model: an observational cohort study protocol. BMJ Open 2022;12:e052518. doi: 10.1136/bmjopen-2021-052518 bmjopen.bmj.com/content/12/1/e052518 Payten CL, Chiapello G, Weir KA and Madill CJ. Frameworks, Terminology and Definitions used for the Classification of Voice Disorders: A Scoping Review. Journal of Voice. https://pubmed.ncbi.nlm.nih.gov/35317970/ For further information, Chris can be contacted on: Christopher.Payten@health.qld.gov.au Speech Pathology Australia acknowledge the Traditional Custodians of lands, seas and waters throughout Australia, and pay respect to Elders past and present. We recognise that the health and social and emotional wellbeing of Aboriginal and Torres Strait Islander peoples are grounded in continued connection to culture, country, language and community and acknowledge that sovereignty was never ceded.

Stynes, Siobhan; Foster, Nadine; O'Dowd, John; Ostelo, Raymond; Konstantinou, Kika. . 'Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study.'. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. DOI > view in repository > Stynes, Siobhan; Snell, Kym IE; Riley, Richard D; Konstantinou, Kika; Cherrington, Andrea; Daud, Noor; Ostelo, Raymond; O'Dowd, John; Foster, Nadine E. 01-11-2023. 'Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol'. BMJ Open. DOI > view in repository > Nagington, A; Foster, NE; Snell, KIE; Konstantinou, K; Stynes, S. 21-01-2023. 'Prognostic factors associated with outcome following an epidural steroid injection for disc-related sciatica: a systematic review and narrative synthesis.'. European Spine Journal. DOI > view in repository > Corp, Nadia; Mansell, Gemma; Stynes, Siobhan; Wynne-Jones, Gwenllian; Morsø, Lars; Hill, Jonathan C.; van der Windt, Danielle A.. 01-09-2021. 'Authors' reply to the comment by Zhang et al'. European Journal of Pain. DOI > view in repository > Stynes, Siobhán; Konstantinou, Kika; Ogollah, Reuben; Hay, Elaine M.; Dunn, Kate M.. 01-04-2016. '241 Identification of Nerve Root Involvement in Primary Care Consulters with Low Back–Related Leg Pain: Diagnostic Classification Using Alternative Approaches'. Rheumatology. DOI > view in repository > Stynes, S; Konstantinou, K; Dunn, KM; Lewis, M; Hay, E. 01-02-2014. 'AGREEMENT AMONG THERAPISTS WHEN DIAGNOSING LOW BACK-RELATED LEG PAIN'. Orthopaedic Proceedings. view in repository > Archer, Lucinda; Snell, Kym I E; Stynes, Siobhán; Axen, Iben; Dunn, Kate M; Foster, Nadine E; Wynne-Jones, Gwenllian; Windt, Daniëlle A; Hill, Jonathan C. . 'Development and External Validation of Individualized Prediction Models for Pain Intensity Outcomes in Patients with Neck Pain, Low Back Pain, or both in Primary Care Settings'. Physical Therapy. DOI > view in repository > Stynes, S. . '050 One-Year Trajectories of Low Back-Related Leg Pain in Primary Care Patients: Analysis Using Growth Mixture Modelling'. Rheumatology. DOI > view in repository > Stynes; Wood, Lianne; Bishop, Annette; Goodwin, Rob. 01-06-2022. 'Patient satisfaction with the first contact physiotherapy service: Results from the national evaluation survey'. Musculoskeletal Care. DOI > view in repository > Saunders, Benjamin; Foster, Nadine E; Hill, Jonathan C; Sowden, Gail; Evans, Nicola; Bishop, Annette; Stynes, Siobhan; Dziedzic, Krysia; Campbell, Laura; Rankin, Gabrielle; Salmon, Paula; Wynne-Jones, Gwenllian. 01-03-2022. 'First Contact Practitioners' (FCPs) and General Practitioners' Perceptions Towards FCPs Delivering Vocational Advice to Patients with Musculoskeletal Conditions: A Qualitative Investigation of the Implementation Potential of the I-SWAP Initiative.'. Journal of Occupational Rehabilitation. DOI > view in repository > Stynes, S.; Jordan, K.P.; Hill, J.C.; Wynne-Jones, G.; Cottrell, E.; Foster, N.E.; Goodwin, R.; Bishop, A.. 01-12-2021. 'Evaluation of the First Contact Physiotherapy (FCP) model of primary care: Patient characteristics and outcomes'. Physiotherapy. DOI > view in repository > Hayward, Rebecca; Stynes, Siobhan. 01-09-2021. 'Self‐efficacy as a prognostic factor and treatment moderator in chronic musculoskeletal pain patients attending pain management programmes: A systematic review'. Musculoskeletal Care. DOI > view in repository > Mansell, Gemma; Corp, Nadia; Wynne-Jones, Gwenllian; Hill, Jonathan; Stynes, Siobhán; van der Windt, Daniëlle. 01-09-2021. 'Self‐reported prognostic factors in adults reporting neck or low back pain: An umbrella review'. European Journal of Pain. DOI > view in repository > Stynes. 06-08-2021. 'Evaluation of the First Contact Physiotherapy (FCP) model of primary care: a qualitative insight'. Physiotherapy. DOI > view in repository > Corp, N; Mansell, G; Stynes, S; Wynne-Jones, G; Morsø, L; Hill, J; Van Der Windt, D. 01-02-2021. 'Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines.'. European Journal of Pain. DOI > view in repository > Stynes, Siobhan. 01-07-2020. 'Musculoskeletal pain phenotyping: Our end point should be clinical feasibility - A commentary to Meisingset et al. "Novel approach towards musculoskeletal phenotypes"'. EUROPEAN JOURNAL OF PAIN. DOI > view in repository > Stynes. 27-08-2019. 'New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica.'. European Journal of Pain. DOI > view in repository >

Guidelines ACC/AHA - Link AF-React Study: artigo BMJ Open 1 - Link AF-React Study: artigo BMJ Open 2 - Link AF-React Study: artigo Frontiers in Medicine - Link (63) Sub e sobretratamento da fibrilhação auricular em Portugal - Link --- Nova Android & iOS app MGFamiliar - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Link⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Subscreva o Podcast MGFamiliar para não perder qualquer um dos nossos episódios. Além disso, considere deixar-nos uma revisão ou um comentário no Apple Podcasts ou no Spotify. --- Music Good Life by BraveLion - Link

Ellen Langer is a psychologist at Harvard who studies the mind-body connection. She's published some of the most remarkable scientific findings Steve has ever encountered. Can we really improve our physical health by changing our mind? SOURCE:Ellen Langer, professor of psychology at Harvard University. RESOURCES:Brave New Words: How AI Will Revolutionize Education (and Why That's a Good Thing), by Sal Khan (2024)."F.D.A.'s Review of MDMA Cites Health Risks and Study Flaws," by Andrew Jacobs and Christina Jewett (The New York Times, 2024).The Mindful Body: Thinking Our Way to Chronic Health, by Ellen Langer (2023)."Physical Healing as a Function of Perceived Time," by Peter Aungle and Ellen Langer (Nature: Scientific Reports, 2023)."Aging as a Mindset: A Study Protocol to Rejuvenate Older Adults With a Counterclockwise Psychological Intervention," by Francesco Pagnini, Cesare Cavalera, Ellen Langer, et al. (BMJ Open, 2019).Counterclockwise: Mindful Health and the Power of Possibility, by Ellen Langer (2009)."Mind-Set Matters: Exercise and the Placebo Effect," by Alia Crum and Ellen Langer (2007)."The Effects of Choice and Enhanced Personal Responsibility for the Aged: A Field Experiment in an Institutional Setting," by Ellen Langer and Judith Rodin (Journal of Personality and Social Psychology, 1976). EXTRAS:"The Future of Therapy Is Psychedelic," by People I (Mostly) Admire (2023)."Extra: An Update on the Khan World School," by People I (Mostly) Admire (2023)."Is This the Future of High School?" by People I (Mostly) Admire (2022)."What It Takes to Know Everything," by People I (Mostly) Admire (2022)."Sal Khan: 'If It Works for 15 Cousins, It Could Work for a Billion People,'" by People I (Mostly) Admire (2021)."Greg Norman & Mark Broadie: Why Golf Beats an Orgasm and Why Data Beats Everything," by People I (Mostly) Admire (2021)."Caverly Morgan: 'I Am Not This Voice. I Am Not This Narrative,'" by People I (Mostly) Admire (2020)."Does 'As If' Thinking Really Work?" by No Stupid Questions (2020)."Havana Wild Weekend," S28.E7 of The Simpsons (2016). 

Listen to Dr Rohan Mehra, RCP clinical education fellow, (Infectious diseases/microbiology SPR) and Dr Mumtaz Patel, as they shine a spotlight on differential attainment in healthcare. This is a pervasive issue within UK healthcare which requires work from everyone. Here Rohan and Mumtaz illustrate the issue, how it impacts people and what you can do to try and make a difference.  Dr Mumtaz Patel is a consultant in nephrology in Manchester as well as Senior censor and Vice President for education for the RCP. Mumtaz led nationally on the research around Differential Attainment for over 5 years and has led cross-collaborative research across organisations such as GMC, NHSE, royal colleges and within different specialties with a focus on earlier interventions and support to improve educational outcomes and trainee experience. Mumtaz has helped produce national guidance around supporting trainers and trainees in addressing and narrowing the Differential attainment gap. This work has had national and international recognition with presentations at multiple conferences. Resources:GMC: tackling differential attainment.https://www.gmc-uk.org/education/standards-guidance-and-curricula/guidance/tackling-differential-attainmentAcademic papers highlighting differential attainment and steps that need taken:Woolf K, Potts HW. Ethnicity and academic performance in UK-trained doctors and medical students: systematic review and meta-analysis. BMJ 2011;342:d901.Regan de Bere S, Nunn S, Nasser M. Understanding differential attainment across medical training pathways: a rapid review of the literature Final report prepared for The General Medical Council. 2015. https://www.gmc-uk.org/-/media/documents/gmc-understanding-differential-attainment_pdf-63533431.pdfWoolfe K, Rich A, Viney R, Needleman S, Griffin A. Perceived causes of differential attainment in UK postgraduate medical training: a national qualitative study. BMJ Open 2016;6:e013429https://www.gmc-uk.org/education/14105.aspHawkridge A, Molyneux D. (2019) A description and evaluation of an educational programme for North West England GP trainees who have multiple fails in the Clinical Skills Assessment (CSA). Education for Primary Care. 30(3):167-172. https://www.gmc-uk.org/-/media/documents/gmc-da-final-report-success-factors-in-training-211119_pdf-80914221.pdfJeremy Brown, Liam Jenkins, John Sandars, Julie Bridson, Mumtaz Patel (2023) Evaluation of the Impact of the Workshop ‘EQiT – Embedding Compassionate, Courageous, Cross-cultural Conversations into Training' General Medical CouncilJeremy Brown, Liam Jenkins, John Sandars, Julie Bridson, Mumtaz Patel (2023) Evaluation of the impact of the Royal College of Psychiatrists Clinical Assessment of Skill and Applied Knowledge masterclass on reducing the attainment gap General Medical Council Academy of Medical Royal Colleges, 2023 Principles for exam preparation, feedback and support for candidates to address the awarding gap.Patel, M. Differential Attainment and implementing successful strategies, RCP commentary 2023, https://70b706f2.flowpaper.com/CommAugust2023v2/#page=18 Music by Bensound.comThis episode was funded by Vertex Pharmaceuticals (Europe) Limited. Vertex had no involvement in the creation and elaboration of this episode and all views and opinions expressed by the presenter and guests are solely their own.

Proton pump inhibitors, or PPIs, are a class of popular drugs that reduce the amount of acid produced in the stomach. They are often the first-line treatment for conditions related to acid, such as esophagitis, non-erosive reflux disease, and peptic ulcer disease. We talk about PPIs and dementia with Misha Kogan, MD, ABIOM, RCST, medical director of the GW Center of Integrative Medicine and associate professor of Medicine here at GW. Studies show that people who take proton pump inhibitors (PPIs) for more than four years and are 45 or older have a 33% higher risk of developing dementia than those who have never taken PPIs. An expert on neurodegenerative diseases, Dr. Kogan completed the Geriatric Fellowship at GW. He is the chief editor of the first definitive textbook on Integrative Medicine and aging, “Integrative Geriatric Medicine,” part of Andrew Weil Integrative Medicine Library series. Dr. Kogan is also on the faculty of the GW Institute for Brain Health and Dementias; associate director of the Geriatrics Fellowship Program at GW; and founder and director othe George Washington University Integrative Geriatrics Fellowship Track. ◘ Related Content Institute for Brain Health and Dementia https://brainhealth.gwu.edu/ Choudhury A, Jena A, Jearth V, et al. Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2023;17(5):479-487. doi:10.1080/17474124.2023.2204229 https://pubmed.ncbi.nlm.nih.gov/37060552/ Gommers LMM, Hoenderop JGJ, de Baaij JHF. Mechanisms of proton pump inhibitor-induced hypomagnesemia. Acta Physiol (Oxf). 2022;235(4):e13846. doi:10.1111/apha.13846 https://pubmed.ncbi.nlm.nih.gov/35652564/ Geng T, Chen JX, Zhou YF, et al. Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2023;108(6):e216-e222. doi:10.1210/clinem/dgac750 https://pubmed.ncbi.nlm.nih.gov/36573284/ Liu W, Wang J, Wang M, Wang M, Liu M. Association of proton pump inhibitor use with risk of kidney stones: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (2007-2018). BMJ Open. 2023;13(10):e075136. Published 2023 Oct 16. doi:10.1136/bmjopen-2023-075136 https://pubmed.ncbi.nlm.nih.gov/37844987/ Gao S, Song W, Lin T, et al. Prolonged Use of Proton Pump Inhibitors, but Not Histamine-2 Receptor Antagonists, Is Associated With Lower Bone Mineral Density in Males Aged Over 70. Front Med (Lausanne). 2021;8:725359. Published 2021 Aug 23. doi:10.3389/fmed.2021.725359 https://pubmed.ncbi.nlm.nih.gov/34497815/ ◘ Transcript https://bit.ly/3V1BoJT ◘ This podcast features the song “Follow Your Dreams” (freemusicarchive.org/music/Scott_Ho…ur_Dreams_1918) by Scott Holmes, available under a Creative Commons Attribution-Noncommercial (01https://creativecommons.org/licenses/by-nc/4.0/) license. ◘ Disclaimer: The content and information shared in GW Integrative Medicine is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in GW Integrative Medicine represent the opinions of the host(s) and their guest(s). For medical advice, diagnosis, and/or treatment, please consult a medical professional.

Die Themen in den Wissensnachrichten: +++ Mittelmeer könnte nach und nach tropisch werden +++ Musikerinnen mit offenem Brief gegen KI +++ Besser Schlafen durch regelmäßige Bewegung +++**********Weiterführende Quellen zu dieser Folge:The dawn of the tropical Atlantic invasion into the Mediterranean Sea, PNAS, 01.04.2024200+ Artists Urge Tech Platforms: Stop Devaluing Music, Medium, 01.04.2024Association between physical activity over a 10-year period and current insomnia symptoms, sleep duration and daytime sleepiness: a European population-based study, BMJ Open, 26.03.2024Data and trained models for: Human-robot facial co-expression, Dryad, 05.03.2024Eurasian aspen (Populus tremula L.): Central Europe's keystone species ‘hiding in plain sight', PLOS ONE, 27.03.2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

The CLOT Conversation Hosts (Dr Jameel Abdulrehman and Dr Maha Othman) discuss Post-Thrombotic Syndrome and the TILE study with two of the authors of the recently published paper, Tinzaparin Lead-in to Prevent the Post-Thrombotic syndrome study protocol, Dr Jean-Phillippe Galanaud and Dr Ilia Makedonov. In the interview the authors discuss the latest research on PTS and the rationale for the TILE study.Dr Jean-Philippe Galanaud is a General Internal Medicine specialist and Thrombosis Physician. He works as a staff physician in the Department of Medicine at Sunnybrook Health Sciences Centre in Toronto; He is associate Professor of Medicine at the University of Toronto.His areas of expertise in research are in the field of the post thrombotic syndrome and of distal DVT; He is currently conducting, with Susan Kahn from McGill, 2 multicentre studies in the field of PTS; 1 on the prevention of post thrombotic syndrome with LMWH (The Tile study) and 1 on the treatment of post thrombotic syndrome with venoactive drugs (The MUFFIN study)AndDr Makedonov completed medical school at the University of Toronto, followed by internal medicine residency in Ottawa. He took a keen interest in thrombosis, doing a fellowship at Sunnybrook and receiving a grant from CanVECTOR. He research has focused on the post thrombotic syndrome as well as distal DVT and cerebral venous sinus thrombosis. He runs a thrombosis clinic at the Southlake Regional Health Centre. He has a broad clinical practice, including peri-partum and cancer associated VTE. In his spare time , he bikes and sails. He hopes to one day own a dog. Reference:  Makedonov I, Kahn S, Abdulrehman J, et al. TILE pilot trial study protocol: Tinzaparin Lead-in to Prevent the Post-Thrombotic syndrome study protocol. BMJ Open 2023;13:e064715. doi:10.1136/ bmjopen-2022-064715  Follow us on twitter: @thrombosiscan Check out our website: https://thrombosiscanada.caSupport the showhttps://thrombosiscanada.caTake a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Canada

A Rebelião Saudável nasceu da união de diversos profissionais de saúde que pensam diferente e cujo foco é promover saúde e bem estar, com comida de verdade e sem medicamentos. Semanalmente a Rebelião se reune no app Telegram para discussão de tópicos importantes relacionados a Nutrição Humana e Qualidade de vida. Nessa semana, a Rebelião discutiu sobre Manteiga X Margarina. Artigos citados no podcast: Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013 Feb 4;346:e8707. doi: 10.1136/bmj.e8707. Erratum in: BMJ. 2013;346:f903. PMID: 23386268; PMCID: PMC4688426. Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open. 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019; PMCID: PMC5855206. Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O. Phytosterols and Cardiovascular Disease. Curr Atheroscler Rep. 2021 Sep 1;23(11):68. doi: 10.1007/s11883-021-00964-x. PMID: 34468867; PMCID: PMC8410723. DiNicolantonio JJ, O'Keefe JH. Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart. 2018 Sep 26;5(2):e000898. doi: 10.1136/openhrt-2018-000898. PMID: 30364556; PMCID: PMC6196963. Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ. 2016 Apr 12;353:i1246. doi: 10.1136/bmj.i1246. PMID: 27071971; PMCID: PMC4836695. Phytosterols may play role in atherosclerosis: https://www.ajmc.com/view/jun04-1804p3# Deol P, Evans JR, Dhahbi J, Chellappa K, Han DS, Spindler S, Sladek FM. Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver. PLoS One. 2015 Jul 22;10(7):e0132672. doi: 10.1371/journal.pone.0132672. PMID: 26200659; PMCID: PMC4511588. Dias CB, Wood LG, Garg ML. Effects of dietary saturated and n-6 polyunsaturated fatty acids on the incorporation of long-chain n-3 polyunsaturated fatty acids into blood lipids. Eur J Clin Nutr. 2016 Jul;70(7):812-8. doi: 10.1038/ejcn.2015.213. Epub 2016 Jan 13. PMID: 26757835. Spiteller G. Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases. Chem Phys Lipids. 1998 Oct;95(2):105-62. doi: 10.1016/s0009-3084(98)00091-7. PMID: 9853364. Alvheim AR, Malde MK, Osei-Hyiaman D, Lin YH, Pawlosky RJ, Madsen L, Kristiansen K, Frøyland L, Hibbeln JR. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. Obesity (Silver Spring). 2012 Oct;20(10):1984-94. doi: 10.1038/oby.2012.38. Epub 2012 Feb 15. PMID: 22334255; PMCID: PMC3458187. Guyenet SJ, Carlson SE. Increase in adipose tissue linoleic acid of US adults in the last half century. Adv Nutr. 2015 Nov 13;6(6):660-4. doi: 10.3945/an.115.009944. PMID: 26567191; PMCID: PMC4642429. Penzo D, Tagliapietra C, Colonna R, Petronilli V, Bernardi P. Effects of fatty acids on mitochondria: implications for cell death. Biochim Biophys Acta. 2002 Sep 10;1555(1-3):160-5. doi: 10.1016/s0005-2728(02)00272-4. PMID: 12206909. Livros para Pesquisa: SHANAHAN, Catherine. The Fatburn Fix: boost energy, end hunger, and lose weight by using body fat for fuel. New York: Flat Iron Books, 2020. 352 p. TEICHOLZ, Nina. Gordura sem Medo: por que a manteiga, a carne e o queijo devem fazer parte de uma dieta saudável. São Paulo: Wmf Martins Fontes, 2020. 464 p. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran.

In 1998, a young Norwegian exercise physiologist found that a technique he had used to help Olympic athletes could help heart patients too. But his idea made doctors sweat. One famous cardiologist told him that if he used his technique in human heart attack patients, he "would kill them."Today's show looks at what happened when our researcher, Ulrik Wisløff, defied the experts — and built a career learning how high intensity interval training can help everyone from heart patients and ageing Baby Boomers, and possibly even Alzheimer's patients — but not in the way you might think!Our guests on today's show are Ulrik Wisløff, Dorthe Stensvold and Atefe Tari.Here's a link to a rat on a treadmill photo.Here's a list of some of the research mentioned in the podcast, with links:Wisløff U, Helgerud J, Kemi OJ, Ellingsen O. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. doi: 10.1161/CIRCULATIONAHA.106.675041. Epub 2007 Jun 4.Øivind Rognmo, Trine Moholdt, Hilde Bakken, Torstein Hole, Per Mølstad, Nils Erling Myhr, Jostein Grimsmo and Ulrik Wisløff. Cardiovascular Risk of High- Versus Moderate-Intensity Aerobic Exercise in Coronary Heart Disease Patients Circulation. 2012;126:1436-1440. doi: 10.1161/CIRCULATIONAHA.112.123117Stensvold D, Viken H, Steinshamn S L, Dalen H, Støylen A, Loennechen J P et al. Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 :m3485 Tari AR, Nauman J, Zisko N, Skjellegrind HK, Bosnes I, Bergh S, Stensvold D, Selbæk G, Wisløff U. Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study. Lancet Public Health. 2019 Nov;4(11):e565-e574.Tari AR, Berg HH, Videm V, Bråthen G, White LR, Røsbjørgen RN, Scheffler K, Dalen H, Holte E, Haberg AK, Selbaek G, Lydersen S, Duezel E, Bergh S, Logan-Halvorsrud KR, Sando SB, Wisløff U. Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study. BMJ Open. 2022 Sep 6;12(9):e056964. Hosted on Acast. See acast.com/privacy for more information.

If you're like me, you want to see the evidence. There is a lot of talk out there about how “fertility mindset” can help you conceive. But is there actual research to back that up? You may be wondering if it's a bunch of woo-woo hocus-pocus or if there is actual science to back up the claims. If you're curious about this approach because something in you thinks it could help, but you're also skeptical because it's outside the scope of typical medical protocol, then this episode will assuage your concerns. I'm bringing out the research from medical journals and explaining how findings suggest that women who participate in mind/body programs can be up to twice as likely to conceive as women who don't. That's a pretty exciting fact! Join me today as we break all this down. And, after you listen o the show, check out the citations down below. For fertility support, inspiration and community, follow me @badassfertility CITATIONS Clifton J, Parent J, Seehuus M, Worrall G, Forehand R, Domar A. An internet-based mind/body intervention to mitigate distress in women experiencing infertility: A randomized pilot trial. PLoS One. 2020 Mar 18;15(3):e0229379. doi: 10.1371/journal.pone.0229379. PMID: 32187236; PMCID: PMC7080396. Domar, A. et al. “Impact of a group Mind/Body Intervention on Pregnancy Rates in IVF Patients,” Fertility and Sterility, vol 75, no. 7: pp 2269 – 2273 (June 2011) Frederiksen Y, Farver-Vestergaard I, Skovgård NG, et al Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis BMJ Open 2015;5:e006592. doi: 10.1136/bmjopen-2014-006592 Rooney KL, Domar AD. The relationship between stress and infertility. Dialogues Clin Neurosci. 2018 Mar;20(1):41-47. doi: 10.31887/DCNS.2018.20.1/klrooney. PMID: 29946210; PMCID: PMC6016043.

In this episode, Dr. Mark Hoffman hosts Dr. Jan Baekelandt, a gynecologic surgeon from Mechelen, Belgium, to discuss a novel gynecologic surgery approach known as vaginal natural orifice transluminal endoscopic surgery (vNOTES). --- SHOW NOTES This technique involves entering the pelvic cavity through the vaginal lumen, eliminating the need for abdominal incisions and promoting a less invasive procedure. Dr. Jan Baekelandt explains that during his career this approach originated from the single-side surgery technique, gradually evolving into a fully transvaginal procedure. He highlights that the advanced tools required for vaginal surgeries now offer equivalent visualization and hemostatic control as laparoscopic techniques, while providing the added benefit of reduced invasiveness. The benefits of vNOTES for patients are discussed, including findings from two randomized control trials comparing vNOTES hysterectomy and adnexectomy to laparoscopic approaches. The results indicate non-inferiority, reduced postoperative pain, decreased analgesic use, and shorter hospital stays for vNOTES. Complications were also lower in the hysterectomy trial. Notably, the vNOTES technique especially benefited patients who were obese, had undergone prior abdominal surgeries, or had large uteruses. Jan underscores the significance of technique standardization to facilitate teaching and complication avoidance. He acknowledges vNOTES-specific complications, such as a higher cystotomy rate, but notes a lower ureter damage rate. However, he cautions that vNOTES might not be suitable for certain patients, like those with endometriosis, prior pelvic inflammatory disease or pelvic abscesses. The potential impact of vNOTES on non-hysterectomy surgeries, future deliveries, and sexual function is briefly discussed, though data in these areas remain limited. Dr. Jan Baekelandt is hopeful that more evidence will emerge to guide physicians. He shares that, based on available data and his own experience, vaginal deliveries following vNOTES have generally proceeded without complications, without a notable increase in cesarean sections or vaginal tears. He notes that to protect sexual function, surgeons should take care to make incisions away from the posterior cervical fornix to avoid subsequent dyspareunia for their patients. The episode concludes with Jan emphasizing the importance of formal training and starting with simpler cases to build proficiency and confidence. He asserts that the best technique for a surgeon is the one that instills confidence in keeping patients safe. --- RESOURCES Baekelandt J, De Mulder PA, Le Roy I, Mathieu C, Laenen A, Enzlin P, Weyers S, Mol BW, Bosteels JJ. HALON-hysterectomy by transabdominal laparoscopy or natural orifice transluminal endoscopic surgery: a randomised controlled trial (study protocol). BMJ Open. 2016 Aug 12;6(8):e011546. doi: 10.1136/bmjopen-2016-011546. PMID: 27519922; PMCID: PMC4985989. Baekelandt JF, De Mulder PA, Le Roy I, Mathieu C, Laenen A, Enzlin P, Weyers S, Mol BWJ, Bosteels JJA. Transvaginal natural orifice transluminal endoscopic surgery (vNOTES) adnexectomy for benign pathology compared with laparoscopic excision (NOTABLE): a protocol for a randomised controlled trial. BMJ Open. 2018 Jan 10;8(1):e018059. doi: 10.1136/bmjopen-2017-018059. PMID: 29326183; PMCID: PMC5780723.

Happy birthday Adam! Join us for this special birthday Pod where we discuss a fascinating new meta-analysis on the association of PPIs and Dementia. Learn about the study's results, methods, a rabbit hole about prediction intervals, and Adam's Tupperware approach to confidence intervals.  Learn more and become a member on https://drjournalclub.com/PPIs and Barrett's Continuing Education Course: https://drjournalclub.com/continuing-education/Ahn N, Nolde M, Krause E, Güntner F, Günter A, Tauscher M, Gerlach R, Meisinger C, Linseisen J, Baumeister SE, Rückert-Eheberg IM. Do proton pump inhibitors increase the risk of dementia? A systematic review, meta-analysis and bias analysis. Br J Clin Pharmacol. 2023 Feb;89(2):602-616. doi: 10.1111/bcp.15583. Epub 2022 Nov 23. PMID: 36331350.Kumar R, Kumar A, Nordberg A, Långström B, Darreh-Shori T. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia. Alzheimers Dement. 2020 Jul;16(7):1031-1042. doi: 10.1002/alz.12113. Epub 2020 May 8. PMID: 32383816.Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011 Feb 10;342:d549. doi: 10.1136/bmj.d549. PMID: 21310794.IntHout J, Ioannidis JP, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016 Jul 12;6(7):e010247. doi: 10.1136/bmjopen-2015-010247. PMID: 27406637; PMCID: PMC4947751.Learn more and become a member at www.DrJournalClub.comCheck out our complete offerings of NANCEAC-approved Continuing Education Courses.

Dr. Mark Neuman and Dr. Sam Falkson join the show to discuss the literature around risks of regional versus general anesthesia for postoperative delirium. Dr. Neuman is the founding Director of the Center for Perioperative Outcomes Research and Transformation and Professor of Anesthesiology at Penn Medicine. Dr. Sam Falkson is an anesthesia resident at the Massachusetts General Hospital. This podcast was recorded as part of the Depth of Anesthesia podcast elective. Thanks for listening! If you enjoy our content, leave a 5-star review on Apple Podcasts and share our content with your colleagues. — Follow us on Instagram @DepthofAnesthesia and on Twitter (X) @DepthAnesthesia for podcast and literature updates. Email us at depthofanesthesia@gmail.com with episode ideas or if you'd like to join our team. Music by Stephen Campbell, MD. — References Guay J, Parker MJ, Gajendragadkar PR, Kopp S. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2016;2(2):CD000521. Ravi B, Pincus D, Choi S, Jenkinson R, Wasserstein DN, Redelmeier DA. Association of duration of surgery with postoperative delirium among patients receiving hip fracture repair. JAMA Netw Open. 2019;2(2):e190111. Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. BMJ Open. 2018;8(12):e020757. Zheng X, Tan Y, Gao Y, Liu Z. Comparative efficacy of Neuraxial and general anesthesia for hip fracture surgery: a meta-analysis of randomized clinical trials. BMC Anesthesiol. 2020 Jun 30;20(1):162. Neuman MD, Feng R, Carson JL, et al. Spinal anesthesia or general anesthesia for hip surgery in older adults. N Engl J Med. 2021;385(22):2025-2035. Rathmell JP, Avidan MS. Patient-centered outcomes after general and spinal anesthesia. N Engl J Med. 2021 Nov 25;385(22):2088–9. Stone AB, Poeran J, Memtsoudis SG. There remains a role for neuraxial anesthesia for hip fracture surgery in the post-REGAIN era. Reg Anesth Pain Med. 2023 Aug;48(8):430-432. doi: 10.1136/rapm-2022-104071. Epub 2023 Mar 28. PMID: 36977527. Li T, Li J, Yuan L, et al. Effect of regional vs general anesthesia on incidence of postoperative delirium in older patients undergoing hip fracture surgery: the raga randomized trial. JAMA. 2022;327(1):50-58.

Do you always feel out of touch with yourself, school, work, or your passions? You may be experiencing burnout. Once you go a long time without addressing this issue, it may spiral into more issues such as depression and low self-esteem. Here are a few signs that you're burnt out. Disclaimer: This is a disclaimer that this video is for informative purposes only. It is not intended to diagnose or treat any condition. Please reach out to a qualified healthcare provider or mental health professional if you are struggling. Some people mistake burnout for laziness, but how do we tell the difference? Watch this video to learn more: https://youtu.be/MLuJ249WnkE Writer: Mary Li Chamae G. Quiachon Script Editor: Isadora Ho Script Manager: Kelly Soong Voice: Amanda Silvera Animator: Hannah Ralden YouTube Manager: Cindy Cheong REFERENCES: GoodTherapy. (2018, August 20). Isolation. www.goodtherapy.org/learn-about-therapy/issues/isolation LearnVest. (2021, June 30). 10 Signs You're Burning Out — And What To Do About It. Forbes. www.forbes.com/sites/learnvest/2013/04/01/10-signs-youre-burning-out-and-what-to-do-about-it/?sh=4388750625b4 Mayo Clinic. (2016, October 15). Insomnia – Diagnosis and treatment – Mayo Clinic. www.mayoclinic.org/diseases-conditions/insomnia/diagnosis-treatment/drc-20355173 Metlaine, A., Sauvet, F., Gomez-Merino, D., Elbaz, M., Delafosse, J., Leger, D., & Chennaoui, M. (2017, January 1). Association between insomnia symptoms, job strain and burnout syndrome: a cross-sectional survey of 1300 financial workers. BMJ Open. bmjopen.bmj.com/content/7/1/e012816 Roberts, C. (2019, October 10). 7 important signs you have burnout — and how to fix it. CNET. www.cnet.com/health/signs-you-have-burnout/ Smith, M., M. A., Segal, J., Ph. D., & Robinson, L. (2021, July 15). Burnout Prevention and Treatment. HelpGuide.Org. https://www.helpguide.org/articles/stress/burnout-prevention-and-recovery.htm Solving Procrastination. (n.d.). Why People Procrastinate: The Psychology and Causes of Procrastination. Retrieved from solvingprocrastination.com/why-people-procrastinate/ Soong, J. (2010, December 6). Depression Traps: Social Withdrawal, Rumination, and More. WebMD. www.webmd.com/depression/features/depression-traps-and-pitfalls WebMD. (n.d.). Signs You're Burned Out. Retrieved from www.webmd.com/balance/ss/slideshow-signs-burnout

Five-year follow-up of patients with knee osteoarthritis not eligible for total knee replacement: results from a randomised trial. Larsen JB, Roos EM, Laursen M, et al. BMJ Open. 2022;12(11):e060169. doi:10.1136/bmjopen-2021-060169 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

The Real Estate (Regulation and Development) Act was introduced in 2016 to protect consumers who had invested in residential real estate projects from malpractices by real estate developers. After the law was passed, most states established real estate regulatory authorities to register and oversee the conduct of real estate developers. What changes did this act try to bring in, and how has this regulatory change benefited consumers? Is the increased information about property litigation that the Maharashtra RERA provides affecting housing prices? Does RERA reduce information asymmetry in the housing market?In this episode of Interpreting India, Vaidehi Tandel and Sahil Gandhi join Anirudh Burman to give us insights into these issues and more. They discuss their recent working paper, co-authored with Anupam Nanda and Nandini Agnihotri. Their study analyses how housing prices change in response to mandatory disclosures under the RERA. The paper is titled, “Do Mandatory Disclosures Squeeze the Lemons? The Case of Housing Markets in India.”Episode ContributorsVaidehi Tandel is an economist working in the areas of urban economics, political economy, and public finance, with a focus on India. Currently, Dr. Tandel is a lecturer in real estate and urban economics at the University of Manchester, UK. Her research has been featured in The Financial Times, The New York Times, The Straits Times, Livemint, and others. Her papers have been published in the Journal of Development Economics, the Journal of Urban Economics, the Journal of Regional Science, Environment and Urbanization, Cities, and BMJ Open, among others. Her current work looks at the politician-builder nexus in Mumbai, agglomeration economies in India, and climate change and adaptation across cities in developing countries.Sahil Gandhi is an urban and real estate economist. Dr. Gandhi is a lecturer at The University of Manchester's School of Environment, Education and Development. His research is in the fields of urban economics, real estate, and land economics. His recent papers are on vacant housing in India, migration and tenure choice, housing supply in Mumbai, and so on. His research has been published in the Journal of Urban Economics, the Journal of Development Economics, the Journal of Regional Science, Environment and Urbanization, and Cities, among others. He has also led a report on affordable housing in India. Dr. Gandhi has bylines in international and Indian media outlets such as The Washington Post, The Hindu, Hindustan Times, The Economic Times, and Livemint, among others. His research has also been cited in The Financial Times, The BBC, The Straits Times, Livemint, and more.---Key Moments(0:00); Introduction(2:39); Chapter 1: The Context Behind RERA(9:56); Chapter 2: Key Regulatory Changes(15:21); Chapter 3: The Case of Maharashtra's RERA(17:27); Chapter 4: Mumbai's High Proportion of Litigated Projects(23:04); Chapter 5: The Aim and Findings of the Study(27:35); Chapter 6: Variations Across Housing Submarkets (32:35); Chapter 7: Luxury Housing and Mandatory Disclosures(35:02); Chapter 8: Non-Luxury Housing and Litigation Costs(36:10); Chapter 9: RERA's Impact on Low- and Middle-Income Consumers(40:36); Chapter 10: Types of Litigation Faced by Projects(43:44); Chapter 11: Future Research in Urban Economics(48:22); Outro---Additional ReadingsDo Mandatory Disclosures Squeeze the Lemons? The Case of Housing Markets in India by Vaidehi Tandel, Sahil Gandhi, Anupam Nanda, and Nandini AgnihotriToo Slow for the Urban March: Litigations and the Real Estate Market in Mumbai, India by Sahil Gandhi, Vaidehi Tandel, Alexander Tabarrok, and Shamika RaviView: Time to Make RERA Roar by Nandini Agnihotri and Sahil GandhiIndia Has to Attack Causes of Land Litigation. Modi's Ease of Doing Business Depends on It by Anirudh Burman Making Land Titles in India Marketable: Using Title Insurance as a Viable Alternative to Conclusive Titling by Anirudh Burman--Carnegie India Socials:Instagram: https://www.instagram.com/carnegieindia/ (@CarnegieIndia)Twitter: https://twitter.com/CarnegieIndiaWebsite: https://carnegieindia.orgYouTube: https://www.youtube.com/c/CarnegieIndia/

An 88-year-old man is preparing for his third decompression surgery for spinal stenosis. His friend wonders if massage therapy might be helpful, or even replace this risky procedure. Join us for a closer look at spinal stenosis and the risks and benefits of this common surgery!   Sponsors:     Books of Discovery: www.booksofdiscovery.com     Host Bio:                    Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com.                                      Recent Articles by Ruth:          “Working with Invisible Pain,” Massage & Bodywork magazine, November/December 2022, page 36, http://www.massageandbodyworkdigital.com/i/1481961-november-december-2022/38   “Unpacking the Long Haul,” Massage & Bodywork magazine, January/February 2022, page 35, www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36. “Chemotherapy-Induced Peripheral Neuropathy and Massage Therapy,” Massage & Bodywork magazine, September/October 2021, page 33, http://www.massageandbodyworkdigital.com/i/1402696-september-october-2021/34.           “Pharmacology Basics for Massage Therapists,” Massage & Bodywork magazine, July/August 2021, page 32, www.massageandbodyworkdigital.com/i/1384577-july-august-2021/34.       Resources:    Pocket Pathology: https://www.abmp.com/abmp-pocket-pathology-app   The Back Jam https://themassagementorinstitute.com/p/backjam   Alhaug, O.K. et al. (2021) ‘Criteria for failure and worsening after surgery for lumbar spinal stenosis: a prospective national spine registry observational study', The Spine Journal, 21(9), pp. 1489–1496. Available at: https://doi.org/10.1016/j.spinee.2021.04.008.   Anderson, D.B. et al. (2019) ‘SUcceSS, SUrgery for Spinal Stenosis: protocol of a randomised, placebo-controlled trial', BMJ Open, 9(2), p. e024944. Available at: https://doi.org/10.1136/bmjopen-2018-024944.   Beatty, R.M. (1987) ‘Persistent nerve root compression by buckling of the longitudinal ligament after chemonucleolysis', Neurosurgery, 20(2), pp. 332–334. Available at: https://doi.org/10.1227/00006123-198702000-00025.   Complications of Spine Surgery (no date). Available at: https://www.umms.org/ummc/health-services/orthopedics/services/spine/patient-guides/complications-spine-surgery   Ep 34 – Spinal Fusion—“I Have a Client Who …” Pathology Conversations with Ruth Werner (2020) Associated Bodywork & Massage Professionals. Available at: https://www.abmp.com/podcasts/ep-34-spinal-fusion-i-have-client-who-pathology-conversations-ruth-werner.   Katz, J.N. et al. (2022) ‘Diagnosis and Management of Lumbar Spinal Stenosis: A Review', JAMA, 327(17), pp. 1688–1699. Available at: https://doi.org/10.1001/jama.2022.5921.   Laminectomy Surgery for Back Pain: Treatment, Risks, Recovery (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/treatments/10895-laminectomy-surgery-for-back-pain   Massage & Bodywork - MARCH | APRIL 2021 (no date). Available at: http://www.massageandbodyworkdigital.com/i/1338685-march-april-2021/36?   Surgery for spinal stenosis linked to lower mortality and costs (no date). Available at: https://www.wolterskluwer.com/en/news/surgery-for-spinal-stenosis-linked-to-lower-mortality-and-costs   What is the latest treatment for spinal stenosis? (2022). Available at: https://www.medicalnewstoday.com/articles/what-is-the-latest-treatment-for-spinal-stenosis

Hormonal birth control is linked with altered mood states, including anxiety and depression as well as exaggerated responses to stress.  Sponsored Message: Support your sleep, mood and metabolic health with MyoRelax and Calm by MYOXCIENCE: https://bit.ly/myo-relax-sleep-blend Use code podcast at checkout to save Link to imagers and articles: https://bit.ly/44HIPZM Time Stamps:  00:00 Altered mood states are linked with hormonal birth control. 00:50 IUD's, other than copper, contain progestins and some have estrogens. 02:00 Elevated depression and stress scores, elevated CRP, and plasma cortisol, are found from hormonal birth control. 04:00 Exaggerated basal neuroendocrine and inflammatory profiles are found with hormonal contraceptive users. 04:20 Hormone users had double the amount of cortisol compared to non-users. 04:40 Synthetic progestins and estrogens are not the same as biologically identical progesterone and estradiol. 07:20 Depression increases your risk from dying from all causes, particularly from cardiovascular disease. 07:45 Neurotransmitter GABA is sensitive to changes in progesterone. 10:50 Neuroactive steroid hormones and the HPAG axis are altered with synthetic hormonal contraceptives. 13:10 History of psychiatric illness increases likelihood of poor mental health while using hormonal contraception. 14:30 Explore birth control alternatives.   Studies Mentioned:   1.Skovlund, C. W., Mørch, L. S., Kessing, L. V. & Lidegaard, Ø. Association of Hormonal Contraception With Depression. Jama Psychiat73, 1154 (2016).   2.Lewis, C. A. et al. Effects of Hormonal Contraceptives on Mood: A Focus on Emotion Recognition and Reactivity, Reward Processing, and Stress Response. Curr Psychiat Rep 21, 115 (2019).   3.Elsayed, M. et al. The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review. World J Biological Psychiatry 1–19 (2022) doi:10.1080/15622975.2022.2145354.   4.Raeder, F. et al. Do oral contraceptives modulate the effects of stress induction on one-session exposure efficacy and generalization in women? Psychopharmacology 240, 1075–1089 (2023).   5.Lacasse, J. M., Ismail, N. & Tronson, N. C. Editorial overview: Hormonal contraceptives and the brain: A call for translational research. Front Neuroendocrin 69, 101063 (2023).   6.Martell, S., Marini, C., Kondas, C. A. & Deutch, A. B. Psychological side effects of hormonal contraception: a disconnect between patients and providers. Contracept Reproductive Medicine 8, 9 (2023).   7.Zettermark, S. et al. Population heterogeneity in associations between hormonal contraception and antidepressant use in Sweden: a prospective cohort study applying intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Bmj Open 11, e049553 (2021).

Dr. Laura Burke is a health sciences researcher and assistant professor of emergency medicine at Harvard Medical School. She gave a reaffirming grand rounds talk to us, packed full of evidence to support the concept that emergency medicine and emergency physicians provide an incredible quality of service and value to the healthcare system overall. Listen in!   Articles she references throughout are listed below in chronological order.   CONTACTS Twitter - @AlwaysOnEM; @VenkBellamkonda; @LauraBurke20 Instagram – @AlwaysOnEM; @Venk_like_vancomycin; @ASFinch Email - AlwaysOnEM@gmail.com REFERENCES & LINKS Li G, Lau JT, McCarthy M, Schull MJ, Vermeulen M, Kelen GD. Emergency Department Utilization in the United States and Ontario, Canada. Acad Emerg Med June 2007, Vol 14, No. 6 Papanicolas I, Woskie LR, Jha AK. Health Care Spending in the United States and Other High-Income Countries. JAMA. 2018;319(10):1024-1039 Papanicolas I, Woskie LR, Orlander D, Orav EJ, Jha AK. The Relationship between health spending and social spending in high-income countries: How does the US compare? Health Aff (Millwood). 2019 Sep;38(9):1567-1575 Zhou RA, Baicker K, Taubman S, Finkelstein AN. The uninsured do not use the emergency department more – they use other care less. Health Affairs (Millwood). 2017 Dec;36(12):2115-2122 Smulowitz PB, Lipton R, Wharam JF, Adelman L, Weiner SG, Burke L, Baugh CW, Schuur JD, Liu SH, McGrath ME, Liu B, Sayah A, Burke MC, Pope JH, Landon BE. Emergency department utilization after the implementation of Massachussetts health reform. Annals of Emergency Medicine. 2011 Sep;58(3):225-234 Singer AJ, Thode HC, Pines JM. US Emergency Department visits and hospital discharges among uninsured patients before and after implementation of the Affordable Care Act. JAMA Network Open. 2019 Apr 5;2(4):e192662 Brook, Robert H., Emmett B. Keeler, Kathleen N. Lohr, Joseph P. Newhouse, John E. Ware, William H. Rogers, Allyson Ross Davies, Cathy D. Sherbourne, George A. Goldberg, Patricia Camp, Caren Kamberg, Arleen Leibowitz, Joan Keesey, and David Reboussin, The Health Insurance Experiment: A Classic RAND Study Speaks to the Current Health Care Reform Debate. Santa Monica, CA: RAND Corporation, 2006. https://www.rand.org/pubs/research_briefs/RB9174.html. Vogel JA, Rising KL, Jones J, Bowden ML, Ginde AA, Havranek EP. Reasons patients choose the emergency department over primary care: A qualitative metasynthesis. J Gen Intern Med. 2019 Nov; 34(11):2610-2619 Chou SC, Gondi S, Baker O, Venkatesh AK, Schuur JD. Analysis of a commercial insurance policy to deny coverage for emergency department visits with nonemergent diagnoses. JAMA network Open. 2018 Oct 5;1(6):e183731 Raven MC, Lowe RA, Maselli J, Hsia RY. Comparison of presenting complaint vs discharge diagnosis for identifying nonemergency emergency department visits. JAMA. 2013 Mar 20;309(11):1145-53 Arnetz BB, Goetz C, vanSchagen J, Baer W, Smith S, Arnetz JE. Patient-reported factors associated with avoidance of in-person care during the COVID-19 pandemic: Results from a national survey. PLoS One. 2022 Aug 5;17(8):e0272609 Sharma M, Lioutas VA, Madsen T, Clark J, O'Sullivan J, Elkind MSV, Willey JZ, Marshall RS, Selim MH, Greer D, Tirschwell DL, Burton T, Boehme A, Aparicio HJ. Decline in stroke alerts and hospitalisations during the COVID-19 pandemic. Stroke Vascular Neurology. 2020 Dec;5(4):403-405 Bradley CJ, Neumark D, Walker LS. The effect of primary care visits on other health care utilization: A randomized controlled trial of cash incentives offered to low income, uninsured adults in Virginia. J Health Economics. 2018 Nov;62:121-133 Peikes D, Dale S, Ghosh A, Taylor EF, Swankoski K, O'Malley AS, Day TJ, Duda N, Singh P, Anglin G, Sessums LL, Brown RS. The comprehensive primary care initiative: effects on spending, quality, patients and physicians. Health Affairs (Millwood). 2018 Jun;37(6):890-899 Song Z, Gondi S. Will increasing primary care spending alone save money? JAMA. 2019 Oct 8;322(14)1349-1350 Weinik RM, Burns RM, Mehrotra A. Many emergency department visits could be managed at urgent care centers and retail clinics. Health Affairs (millwood). 2010 Sep;29(9):1630-6 Wang B, Mehrotra A, Friedman AB. Urgent care centers deter some emergency department visits but, on net, increase spending. Health Affairs (Millwood). 2021 Apr;40(4):587-595 Pitts SR, Pines JM, Handrigan MT, Kellermann AL. National trends in emergency department occupancy, 2001-2008:effect of inpatient admissions versus emergency department practice intensity. Annals of Emergency Medicine. 2012 Dec;60(6):679-686 Burke LG, Wild RC, Orav EJ, Hsia RY. Are trends in billing for high-intensity emergency care explained by changes in services provided in the emergency department? An observational study among US Medicare beneficiaries. BMJ Open. 2018 Jan 30;8(1):e019357 Schuur JD, Venkatesh AK. The growing role of emergency departments in hospital admissions. NEJM. 2012 Aug 2;367(5):391-3 Chou SC, Baker O, Schuur JD. Changes in Emergency Department Care Intensity from 2007-16: Analysis of the National Hospital Ambulatory Medical Care Survey. Western Journal of Emergency Medicine. 2020 Feb 21;21(2):209-216 Janke AT, Gettel C, Vacirca RK, Lin MP, Kocher KE, Venkatesh AK. Trends in treat and release emergency care visits with high-intensity billing in the US, 2006-19. Health Affairs (Millwood). 2022 Dec;41(12)1772-1780 Gani F, Canner JK, Pawlik TM. Assessing coding practices for gastrointestinal surgery over time in the United States. Surgery. 2018 Sep;164(3):530-538 Schonberger RB, Dutton RP, Dai F. Is there evidence for systematic upcoding of ASA physical status coincident with payer incentives? A regression discontinuity analysis of the national anesthesia clinical outcomes registry. Anesthesia Analgesia. 2016 Jan;122(1):243-50 Rajkumar CA, Suh WM, Francis DP. Upcoding of clinical information to meet appropriate use criteria for percutaneous coronary intervention. Circulation: Cardiovascular Quality and Outcomes. 2019 Mar;12(3):e005025 Smulowitz PB, Honigman L, Landon BE. A novel approach to identifying targets for cost reduction in the emergency department. Annals of Emergency Medicine. 2013 Mar;61(3):293-300 Burke LG, Burke RC, Epstein SK, Orav EJ, Jha AK. Trends in costs of care for Medicare beneficiaries treated in the emergency department from 2011 to 2016. JAMA Network Open. 2020 Aug 3;3(8):e208229 Tsai TC, Greaves F, Zheng J, Orav EJ, Zinner MJ, Jha AK. Better patient care at high-quality hospitals may save medicare money and bolster episode-based payment models. Health Affairs (Millwood). 2016 Sep 1;35(9):1681-9 Lin MP, Baker O, Richardson LD, Schuur JD. Trends in emergency department visits and admission rates among US acute care hospitals. JAMA Intern Med. 2018 Dec 1;178(12):1708-1710 Pomerantz A, Burke R, Friedman A, Burke L, Wolfe R, Smulowitz P. The influence of Medicare for all on reimbursement for emergency care treat-and-release visits. Annals of Emergency Medicine. 2020 Oct;76(4):454-458 Obermeyer Z, Cohn B, Wilson M, Jena AB, Cutler DM. Early death after discharge from emergency departments: analysis of national US insurance claims data. BMJ. 2017 Feb 1;356:j239 Burke LG, Epstein SK, Burke RC, Orav EJ, Jha AK. Trends in mortality for medicaire beneficiaries treated in the emergency department from 2009 to 2016. JAMA Internal Medicine. 2020 Jan 1;180(1):80-88 Marco CA, Courtney DM, Ling LJ, Salsberg E, Reisdorff EJ, Gallahue FE, Suter RE, Muelleman R, Chappell B, Evans DD, Vafaie N, Richwine C. The emergency medicine physician workforce: projections for 2030. Annals of Emergency Medicine. 2021 Dec;78(6):726-737 Paul Genberg. The Value of Being a Generalist. Forbes. June 3, 2021

A question I get asked all the time - Should I be taking a multivitamin supplement as a triathlete? As overachieving endurance athletes, we have a higher need for many vitamins and minerals compared to someone that's more sedentary. But do we need to supplement? Or can we get everything we need from our diet? In this episode I talk about: The 13 essential vitamins our body needs for normal, healthy functioning What happens if certain vitamins are missing from our diet? Are there any adverse effects if we get too much? Water soluble vs fat soluble vitamins When would vitamin supplements be useful? My simple answer for the question - Do you need to take a multivitamin supplement?   Tune in to learn more! LINKS Paper Referenced:  Paranjpe et al. 2020. Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study. BMJ Open. Available from: https://bmjopen.bmj.com/content/10/11/e039119   Join the waitlist for our next Triathlon Nutrition Academy opening:  www.dietitianapproved.com/academy Triathlon Nutrition Checklist: Check how well you're doing when it comes to your nutrition: dietitianapproved.com/checklist Website: www.dietitianapproved.com Instagram: @Dietitian.Approved  @triathlonnutritionacademy Facebook: www.facebook.com/DietitianApproved   The Triathlon Nutrition Academy is a podcast by Dietitian Approved. All rights reserved. www.dietitianapproved.com/academySee omnystudio.com/listener for privacy information.

A lot of therapies address the context in which nonsuicidal self-injury (NSSI) and self-harm may occur, but only a few treatments have been designed to address NSSI specifically. In this episode, we dive into one of these treatments: Emotion Regulation Group Therapy (ERGT). Drs. Kim Gratz and Matthew Tull from the University of Toledo in Ohio walk us through in significant detail each of the 90-minute 14 sessions of ERGT.Learn more about Dr. Gratz here and reach her at klgratz28@gmail.com. Learn more about Dr. Tull here and follow him on Twitter @MTTull. Learn more about the Personality and Emotion Research and Treatment (PERT) Laboratory within the Department of Psychology at the University of Toledo here, and follow the PERT Lab on Twitter @LabPert. Below are links to their research on ERGT referenced in this episode:Gratz, K. L., & Gunderson, J. G. (2006). Preliminary data on an acceptance-based emotion regulation group intervention for deliberate self-harm among women with Borderline Personality Disorder. Behavior Therapy, 37(1), 25-35.Gratz, K. L., & Tull, M. T. (2011). Extending research on the utility of an adjunctive emotion regulation group therapy for deliberate self-harm among women with borderline personality pathology. Personality Disorders: Theory, Research, and Treatment, 2(4), 316–326.Gratz, K. L., Tull, M. T., & Levy, R. (2014). Randomized controlled trial and uncontrolled 9-month follow-up of an adjunctive emotion regulation group therapy for deliberate self-harm among women with borderline personality disorder. Psychological Medicine, 44, 2099–2112.Gratz, K. L., Bardeen, J. R., Levy, R., Dixon-Gordon, K., L., & Tull, M. T. (2015). Mechanisms of change in an emotion regulation group therapy for deliberate self-harm among women with borderline personality disorder. Behaviour Research and Therapy, 65, 29-35.Sahlin, H., Bjureberg, J., Gratz, K. L., Tull, M. T., Hedman, E., Bjarehed, J., Jokinen, J., Lundh, L., Ljotsson, B., & Hellner, C. (2017). Emotion regulation group therapy for deliberate self-harm: A multi-site evaluation in routine care using an uncontrolled open trial design. BMJ Open, 7(10), e016220.Follow Dr. Westers on Instagram and Twitter (@DocWesters). To join ISSS, visit itriples.org and follow ISSS on Facebook and Twitter (@ITripleS).The Psychology of Self-Injury podcast has been rated #5 by Feedspot in their "Best 20 Clinical Psychology Podcasts" and by Welp Magazine in their "20 Best Injury Podcasts."

FOURIER authors' response, a possible practice-changing paper in electrophysiology, and the ATLAS and CAPLA trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. FOURIER Authors Respond Recount of FOURIER Data Finds Higher Mortality With Evolocumab; Trialists Push Back https://www.medscape.com/viewarticle/986634 Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data https://bmjopen.bmj.com/content/12/12/e060172 Letter to the Editor RE: "Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data". BMJ Open https://bmjopen.bmj.com/content/12/12/e060172.responses#letter-to-the-editor-re-restoring-mortality-data-in-the-fourier-cardiovascular-outcomes-trial-of-evolocumab-in-patients-with-cardiovascular-disease-a-reanalysis-based-on-regulatory-data-bmj-open-2022123060172 Risk of selection bias assessment in the NINDS rt-PA stroke study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202115/ Methodological survey of missing outcome data in an alteplase for ischemic stroke meta-analysis https://doi.org/10.1111/ane.13656 II. A Potential Practice-Changing Paper in Cardiac Pacing Novel 'Cure' May Avert Lead Extraction in CIED Pocket Infections https://www.medscape.com/viewarticle/986762 Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections https://doi.org/10.1016/j.jacc.2022.10.022 Treatment of Localized Implantable Cardiac Device Pocket Infections https://doi.org/10.1016/j.jacc.2022.11.018 III. ATLAS Trial Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations https://doi.org/10.7326/M22-1566 Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1915932 Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/10.1056/NEJMc2034917 IV. CAPLA Published CAPLA Shows Limits of Further Ablation Post PVI in Persistent AF https://www.medscape.com/viewarticle/986901 Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800186 Catheter Ablation for Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800200 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Amidst the battle of the mental health crisis, major depressive disorder stands out as an all-too-common reality for many children and adolescents, but the forces of science and medicine can stand against this foe. Dr. Christopher Drescher, a clinical child psychologist, joins pediatric resident Dr. Daniel Allen and medical student Vuk Lacmanovic to remove the cape from this increasingly common condition and discuss its symptoms, diagnosis, and treatment. Specifically, they will: Define major depressive disorder (MDD) and recognize the common symptoms in both children and adolescents. Formulate a differential diagnosis for patients presenting with depressive symptoms. Recognize validated screening tools for depression in both children and adolescents. Review cognitive behavioral therapy and pharmacotherapy as treatment options. Review appropriate referral to a mental health specialist. Free CME Credit (requires sign-in): https://mcg.cloud-cme.com/course/courseoverview?P=0&EID=12493  References: Bhatia SK, Bhatia SC. Childhood and adolescent depression. Am Fam Physician. 2007 Jan 1;75(1):73-80. PMID: 17225707. Brent DA, Maalouf F. Depressive Disorders (in Childhood and Adolescence). In: Ebert MH, Leckman JF, Petrakis IL. eds. Current Diagnosis & Treatment: Psychiatry, 3e. McGraw-Hill; Accessed November 17, 2020. https://accessmedicine.mhmedical.com/content.aspx?bookid=2509§ionid=200807606 Clark MS, Jansen KL, Cloy JA. Treatment of childhood and adolescent depression. Am Fam Physician. 2012 Sep 1;86(5):442-8. PMID: 22963063. Fendrich M, Weissman MM, Warner V. Screening for depressive disorder in children and adolescents: validating the Center for Epidemiologic Studies Depression Scale for Children. Am J Epidemiol. 1990 Mar;131(3):538-51. doi: 10.1093/oxfordjournals.aje.a115529. PMID: 2301363. (PDF of CES-DC here) Forman-Hoffman V, McClure E, McKeeman J, Wood CT, Middleton JC, Skinner AC, Perrin EM, Viswanathan M. Screening for Major Depressive Disorder in Children and Adolescents: A Systematic Review for the U.S. Preventive Services Task Force. Ann Intern Med. 2016 Mar 1;164(5):342-9. doi: 10.7326/M15-2259. Epub 2016 Feb 9. PMID: 26857836. Hathaway EE, Walkup JT, Strawn JR. Antidepressant Treatment Duration in Pediatric Depressive and Anxiety Disorders: How Long is Long Enough? Curr Probl Pediatr Adolesc Health Care. 2018 Feb;48(2):31-39. doi: 10.1016/j.cppeds.2017.12.002. Epub 2018 Jan 12. PMID: 29337001; PMCID: PMC5828899. March JS, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, Domino M, McNulty S, Vitiello B, Severe J. The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes. Arch Gen Psychiatry. 2007 Oct;64(10):1132-43. doi: 10.1001/archpsyc.64.10.1132. Erratum in: Arch Gen Psychiatry. 2008 Jan;65(1):101. PMID: 17909125. Meister R, Abbas M, Antel J, Peters T, Pan Y, Bingel U, Nestoriuc Y, Hebebrand J. Placebo response rates and potential modifiers in double-blind randomized controlled trials of second and newer generation antidepressants for major depressive disorder in children and adolescents: a systematic review and meta-regression analysis. Eur Child Adolesc Psychiatry. 2020 Mar;29(3):253-273. doi: 10.1007/s00787-018-1244-7. Epub 2018 Dec 8. PMID: 30535589; PMCID: PMC7056684. Rachel A. Zuckerbrot, Amy Cheung, Peter S. Jensen, Ruth E.K. Stein, Danielle Laraque and GLAD-PC STEERING GROUP. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management. Pediatrics March 2018, 141 (3) e20174081; DOI: https://doi.org/10.1542/peds.2017-4081 Scott K, Lewis CC, Marti CN. Trajectories of Symptom Change in the Treatment for Adolescents With Depression Study. J Am Acad Child Adolesc Psychiatry. 2019 Mar;58(3):319-328. doi: 10.1016/j.jaac.2018.07.908. Epub 2019 Jan 8. PMID: 30768414; PMCID: PMC6557284. Sharma T, Guski LS, Freund N, Gøtzsche PC. Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ. 2016 Jan 27;352:i65. doi: 10.1136/bmj.i65. PMID: 26819231; PMCID: PMC4729837. Siu AL; US Preventive Services Task Force. Screening for Depression in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Pediatrics. 2016 Mar;137(3):e20154467. doi: 10.1542/peds.2015-4467. Epub 2016 Feb 8. PMID: 26908686. Weersing VR, Brent DA, Rozenman MS, Gonzalez A, Jeffreys M, Dickerson JF, Lynch FL, Porta G, Iyengar S. Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial. JAMA Psychiatry. 2017 Jun 1;74(6):571-578. doi: 10.1001/jamapsychiatry.2017.0429. PMID: 28423145; PMCID: PMC5539834. Weersing VR, Shamseddeen W, Garber J, Hollon SD, Clarke GN, Beardslee WR, Gladstone TR, Lynch FL, Porta G, Iyengar S, Brent DA. Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. J Am Acad Child Adolesc Psychiatry. 2016 Mar;55(3):219-26. doi: 10.1016/j.jaac.2015.12.015. Epub 2016 Jan 18. PMID: 26903255; PMCID: PMC4783159. Xu Y, Bai SJ, Lan XH, Qin B, Huang T, Xie P. Randomized controlled trials of serotonin-norepinephrine reuptake inhibitor in treating major depressive disorder in children and adolescents: a meta-analysis of efficacy and acceptability. Braz J Med Biol Res. 2016 May 24;49(6):e4806. doi: 10.1590/1414-431X20164806. PMID: 27240293; PMCID: PMC4897997. Zhou X, Cipriani A, Zhang Y, Cuijpers P, Hetrick SE, Weisz JR, Pu J, Giovane CD, Furukawa TA, Barth J, Coghill D, Leucht S, Yang L, Ravindran AV, Xie P. Comparative efficacy and acceptability of antidepressants, psychological interventions, and their combination for depressive disorder in children and adolescents: protocol for a network meta-analysis. BMJ Open. 2017 Aug 11;7(8):e016608. doi: 10.1136/bmjopen-2017-016608. PMID: 28801423; PMCID: PMC5629731. Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P. Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis. Lancet Psychiatry. 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. PMID: 32563306; PMCID: PMC7303954.

VIDEO: Tulsi Gabbard: Zelenskyy shut down the biggest Ukrainian church in the country (3:18) Tulsi Gabbard destroys Trudeau #trudeaumustgo #canada #chrystiafreeland #tulsigabbard New leak claims FBI grilled Twitter on ‘state propaganda' (4:41) From the frontlines, the USEU/UK war on school playgrounds in Donbass. Eva Bartlett (6:58) Mediterranean diet linked to lower preeclampsia risk Cedars-Sinai Medical Center, December 22, 2022 In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, investigators from the Smidt Heart Institute at Cedars-Sinai found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy. The study, published in the peer-reviewed journal JAMA Network Open, also evaluated the association between the Mediterranean diet and other adverse pregnancy outcomes, including gestational diabetes and hypertension, preterm birth, delivery of a small-for-gestational-age infant, and stillbirth. “This multicenter, population-based study validates that a healthier eating pattern is associated with a lower risk of adverse pregnancy outcomes, the most exciting being a 28% lower risk for preeclampsia,” said Natalie Bello, MD, MPH, senior and corresponding author of the study and director of Hypertension Research in the Smidt Heart Institute. “Importantly, this connection between the Mediterranean diet and lower risk of adverse pregnancy outcomes was seen in a geographically, racially and ethnically diverse population.” Bello also notes that researchers found the association was stronger in women who are traditionally considered to be of advanced maternal age, those 35 or older. Preeclampsia is a serious blood pressure condition that develops during pregnancy and puts stress on the mother's heart. Left untreated, the condition can cause serious complications like weakened kidney and liver function and decreased blood supply to the fetus. In addition to preeclampsia, the risk of gestational diabetes also decreased in women who more closely followed the heart-healthy diet. The study was part of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be, which enrolled 10,038 women . Of the women enrolled, 7,798 were included in the JAMA Network Open study. Women who were pregnant with their first child were asked to complete a semi-quantitative food frequency questionnaire during their first study visit, which occurred in the first trimester. The questionnaire focused on the women's eating habits during the three months prior to their visit and asked the participants to report their intake of common foods and beverages. Individuals' responses were then categorized into the nine components of a Mediterranean diet—vegetables, fruits, nuts, whole grains, legumes, fish, monounsaturated-to-saturated fat ratio, red and processed meats, and alcohol—to calculate a Mediterranean diet score. The data was compiled, analyzed and studied by researchers and showed: A high Mediterranean diet score was related to 21% lower odds of having any adverse pregnancy outcome, as well as a 28% and 37% lower risk of having preeclampsia/eclampsia and gestational diabetes. (NEXT) Almond findings continue to demonstrate prebiotic promise University of Florida, December 17, 2022 Eating almonds is beneficial to maintaining a healthy gut microbiota composition and improving the diet quality of parents and children suggests a new study. The research is the first to monitor the effects of dietary change on digestive health and immune function in a parent and child and whether this positively affects immunity, inflammation and general health. Writing in Nutrition Research, researchers began by enrolling 29 healthy parent and child pairs in to a 14-week, randomised, controlled, crossover study. Parents and children consumed 1.5 and 0.5 ounces of almonds and/or almond butter, respectively, on a daily basis for three weeks, as part of their usual diet, followed by a 6-week washout period and another 3-week period of following the usual diet with no almonds. Using the Healthy Eating Index (HEI) score—a measure of adherence to recommended dietary guidance—parents and children increased their scores to 61.4, (above national averages of 57.4 for adults 31-50 years and 54.9 for children 4-8 years). HEI scores also increased for fatty acids, total protein, seafood and plant protein and decreased for fruit and empty calories. When eating almonds, participants also consumed more vitamin E and magnesium, two nutrients lacking in the majority of adult's and children's diets. Almond consumption also seemed to change gut bacteria levels in subjects. Although the children consumed one-third of the amount of almonds compared to adults, microbiota was affected to a greater extent in their bodies. No specific changes in immune markers were noted. Last year, NutraIngredients reported on a study in which fibre-rich almonds and their skin may selectively boost the populations of Bifidobacterium spp. and Lactobacillus spp in the gut. The study suggested that populations of these bacteria were enhanced after six weeks of consuming almonds or almond skins. (NEXT) Probiotic bacteria found in fermented foods might help dispel bad breath Sichuan University (China), December 21, 2022 Probiotic bacteria usually found in fermented foods, such as yoghurt, sourdough bread, and miso soup, might help dispel the embarrassment of persistent bad breath (halitosis), finds a pooled data analysis of the available evidence, published in the open access journal BMJ Open. Lactobacillus salivarius, Lactobacillus reuteri, Streptococcus salivarius, Weissella cibaria, taken in the form of supplements in this study, may help freshen the breath, but more good quality research is needed, say the researchers. Volatile sulphuric compounds are the main cause of persistent bad breath. These compounds are produced by mouth bacteria as a result of bacterial mixing and food debris associated with poor gum and dental hygiene. Options used to tackle the problem include mouthwashes, chewing gums, teeth scaling and tongue scraping. Emerging evidence suggests that probiotic bacteria might offer a simpler alternative. To explore this further, and find out how long any such effects might last, the researchers trawled research databases for relevant randomised clinical trials published up to February 2021. Probiotics may inhibit the decomposition of amino acids and proteins by anaerobic bacteria in the mouth, so curbing the production of smelly by-products, the researchers explain. (NEXT) War metaphors for cancer hurt certain prevention behaviors University of Michigan, December 15, 2022 It's not unusual for people to use war metaphors such as “fight” and “battle” when trying to motivate patients with cancer. But a University of Michigan study indicates that using those words can have an unintended negative effect. David Hauser, a U-M doctoral student in psychology, and colleague Norbert Schwarz, found in three studies that exposure to metaphoric language relating cancer to an enemy significantly lessens the extent to which people consider cancer-prevention behaviors. “Hearing metaphoric utterances is enough to change the way we think about a concept,” said Hauser, the study's lead investigator. “When we hear the phrase ‘win the battle against cancer,' it forces us to think of cancer as if it's an enemy that we are at war with.”These metaphors emphasize power and taking aggressive actions toward an enemy. However, the bulk of cancer prevention behaviors–such as curbing alcohol intake, salty foods and smoking–involve limitation and restraint. None of them fit with an enemy metaphor that promotes power and aggression, the researchers said. “Hence, enemy metaphors de-emphasize this subset of beneficial prevention behaviors and hurts people's willingness to engage in them,” he said. In one study, the authors asked participants to list cancer-prevention behaviors they would be willing to undertake. For one group of participants, the request contained metaphors relating cancer to an enemy (“What things would you do to fight against developing cancer?”). For a second group, the request contained no metaphors. The group exposed to the enemy metaphor listed significantly less limitation-related prevention behaviors. “This suggests that simply seeing war metaphors for cancer diminishes the extent to which these behaviors come to mind,” Hauser said. In another study, 313 participants read one of two health information passages about colorectal cancer. One passage contained metaphors relating cancer to an enemy (“This disease involves an enemy uprising of abnormal cellular growth in the large intestine.”), whereas the second passage contained no enemy metaphors. Participants then rated the extent to which they intended to engage in various prevention, screening and treatment behaviors. Those who read the enemy metaphor passage had less intention to engage in limitation-related prevention behaviors (such as limiting red meat intake or excessive alcohol consumption) than the participants who read the second passage. “Enemy metaphoric language for cancer diminishes people's intentions for these types of prevention behaviors,” Schwarz said. “Importantly, these negative effects of enemy metaphors on prevention behaviors are not accompanied by a positive effect on intentions to undertake screening or treatment behaviors.” War and enemy metaphors are the most common metaphors found in science journalism about cancer, and they pervade public discourse about the disease.”Fight and battle are actually among the top 10 verbs used to describe cancer,” Hauser said. “Constant exposure to even minor metaphorical utterances may be enough to make enemy metaphors for cancer a powerful influence on public health–with unfortunate side-effects.” (NEXT) More proof that cannabis is an anti-aging powerhouse to rapidly restore memory performance of older mice Hebrew University Jerusalem & University of Bonn (Germany), December 14, 2022 Scientists from The Hebrew University of Jerusalem and the University of Bonn teamed up to examine the potential brain benefits of cannabis in mice. This amazing study is years in the making, with the researchers having built a strong body of evidence on the brain benefits of THC. To conduct their study, researchers administered a small amount of THC, derived from cannabis, to mice aged two, twelve and 18 months old for the course of one month. Some mice were given a placebo. As sources explain, mice have very short life spans and show substantial cognitive deficiencies at just 12 months of age. Afterwards, the mice were subjected to a battery of tests to gauge their learning capacity and memory. Incredibly, the team found that older mice treated with cannabis displayed cognitive function that was as good as the youngest control subjects. As reported by The Hebrew University of Jerusalem: Mice that were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. “The treatment completely reversed the loss of performance in the old animals,” reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation. In past studies, the team found that brain aging is accelerated when THC receptors are absent, prompting them to investigate further. In the brain, THC acts very similarly to the cannabinoids naturally produced by the body. “With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces. When the activity of the cannabinoid system declines, we find rapid aging in the brain,” Prof. Zimmer commented. Treating the mice with THC yielded incredibly impressive epigenetic changes in their brains, and the number of links between neurons dramatically increased, as well. “It looked as though the THC treatment turned back the molecular clock,” Zimmer commented. (NEXT) Brussels Sprouts Have As Much Vitamin C As Oranges – And Plenty Of Other Health Benefits Quadram Institute, December 22, 2022 For many people, Christmas dinner is not complete without a side helping of Brussels sprouts. Indeed, they are Britain's favourite Christmas dinner vegetable. But if you're not a convert, perhaps these health benefits will convince you to give them a second chance. Sprouts belong to the wholesome family of cruciferous or brassica vegetables, including cabbage, kale and broccoli. As with all brassica, Brussels sprouts are packed with fibre, which is good for keeping the beneficial bacteria in your gut happy. They also provide essential minerals, such as potassium and calcium, to keep your muscle and bones healthy. They are rich in vitamins K and C, supporting a healthy immune system and bones. Pound for pound, you'll get more vitamin C from them when eaten raw than from oranges. Cooked Brussels sprouts still contain vitamin C, though – about the same pound for pound as you'd get from orange juice and raw oranges.Most importantly, Brussels sprouts are rich in a wide range of natural chemicals, such as carotenoids and polyphenols, that have been linked to good health. They are particularly abundant in sulphur-containing compounds called glucosinolates. Several scientific studies have shown that these sulphurous compounds are potent antioxidants that can promote health by preventing cell damage. Several studies have also shown that consuming more of these glucosinolates from cruciferous vegetables, including Brussels sprouts, broccoli, kale and cabbage, are associated with a reduced risk of developing a wide range of cancers. Research continues collecting more evidence of their benefits, but the best advice to keep in mind is to try to consume roughly five portions of brassica vegetables weekly and to vary the options.

Videos : The Covid Redemption with Tim Robbins – #048 – Stay Free with Russell Brand MP calls for complete suspension of mRNA jab in extraordinary British Parliamentary speech Turmeric studied for its ability to seek out and destroy cancer stem cells, the source of all tumors Montclair State University, December 13, 202 Turmeric has gained immense popularity over the years not just for the unique flavor it adds to dishes like curries, but also for its various health benefits. One of its most promising therapeutic applications is as a natural remedy for cancer. Although the anticancer potential of turmeric isn't new, a recent study published in Cancer Letters further proved the importance of this golden spice in understanding and treating cancer. The team of American researchers evaluated the ability of curcumin, which is a polyphenol in turmeric, to target cancer stem cells that are assumed to be the primary cause of cancer tumor formation and malignancy. Unlike conventional cancer models used in previous studies, the cancer stem cell model suggests that only a small population of cancer cells drive the initiation, maintenance, and growth of tumors. These stem cells regularly undergo renewal and differentiation into other cancer cells, which no longer have the ability to regenerate themselves. Therefore, in this model, cancer stem cells that are not killed by treatments lead to the formation of more invasive and treatment-resistant tumors. In this study, the researchers found that curcumin is more effective in eradicating cancer since unlike conventional treatments, this polyphenol also targets cancer stem cells. It can do so through various mechanisms of action, which include the following. Regulation of cancer stem cell self-renewal pathway — There are different pathways involved in the self-renewal of cancer stem cells. These include the Wnt/beta-catenin, sonic hedgehog 89 (SHH), and Notch pathways. The researchers found that curcumin can directly or indirectly interfere with these pathways in 12 different cancer cell lines Modulation of microRNA — The body contains microRNAs, which are short RNA sequences that don't encode for anything. These microRNAs regulate more than 33 percent of protein-coding genes by targeting and binding to their corresponding messenger RNAs so that these won't be expressed. In this study, the authors observed that curcumin altered microRNA expression in cancer stem cells so that they can't produce everything that they need for tumor formation and growth. Direct anti-cancer activity — Curcumin selectively targets cancer cells and programs their death. When used in conjunction with conventional anticancer agents, this effect becomes more evident and the damage typically caused by chemotherapy is no longer observed. Overall, the results of this study show that for cancer treatments to be effective, they have to target and kill cancer stem cells just like turmeric does. Otherwise, these cancer stem cells will pave the way for the formation of more invasive and treatment-resistant tumors. (NEXT) Chiropractic spinal manipulation associated with reduction in low back surgery University Hospitals Cleveland Medical Center, December 19, 2022 A recent study from University Hospitals (UH) Connor Whole Health has found that adults who initially visit a chiropractor to receive spinal manipulation for low back pain caused by disc herniation or radiculopathy (i.e., sciatica) are less likely to undergo discectomy (i.e., disc surgery) over the subsequent two years. This study was recently published in the journal BMJ Open. In this retrospective cohort study, the authors selected adult patients, age 18 to 49, from a 101 million patient United States health records network (TriNetX, Cambridge, MA, U.S.). Patients with serious pathology or urgent indications for surgery were excluded from the study. Ultimately, the authors identified 5,785 patients who initially received chiropractic spinal manipulative therapy, and the same number of patients who received other forms of medical care for their low back pain. The authors used a statistical technique called propensity score matching to control for variables that could influence the likelihood that patients would undergo discectomy. In this process, they matched patients in both cohorts according to several such as age, sex, obesity, smoking, previous injections, and medications. The authors found that patients who initially received chiropractic spinal manipulation for their low back pain were significantly less likely to undergo lumbar discectomy through two years' follow-up. At one year follow-up, 1.5% of the patients in the chiropractic cohort had undergone discectomy, compared to 2.2% of patients in the cohort receiving other care At two years' follow-up, 1.9% of the patients in the chiropractic cohort had undergone discectomy, compared to 2.4% of patients in the cohort receiving other care This study represents the first study to examine whether chiropractic care is associated with a reduction in likelihood of discectomy. (NEXT) High-intensity exercise delays Parkinson's progression Northwestern Medicine and University of Denver, December 11, 2022 High-intensity exercise three times a week is safe for individuals with early-stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by Northwestern Medicine and University of Denver scientists. This is the first time scientists have tested the effects of high-intensity exercise on patients with Parkinson's disease, the second most common neurodegenerative disorder and the most common movement disorder, affecting more than a million people in the United States. It previously had been thought high-intensity exercise was too physically stressful for individuals with Parkinson's disease. “If you have Parkinson's disease and you want to delay the progression of your symptoms, you should exercise three times a week with your heart rate between 80 to 85 percent maximum. Because medications for Parkinson's have adverse side effects and reduced effectiveness over time, new treatments are needed. The randomized clinical trial included 128 participants ages 40 to 80 years old from Northwestern University, Rush University Medical Center, the University of Colorado and the University of Pittsburgh. Participants enrolled in the Study in Parkinson Disease of Exercise (SPARX) were at an early stage of the disease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by medication. “The earlier in the disease you intervene, the more likely it is you can prevent the progression of the disease,” Corcos said. “We delayed worsening of symptoms for six months; whether we can prevent progression any longer than six months will require further study.” Scientists examined the safety and effects of exercise three times weekly for six months at high intensity, 80 to 85 percent of maximum heart rate, and moderate intensity, 60 to 65 percent of maximum heart rate. They compared the results to a control group who did not exercise. After six months, participants were rated by clinicians on a Parkinson's disease scale ranging from 0 to 108. The higher the number, the more severe the symptoms. Participants in the study had a score of about 20 before exercise. Those in the high intensity group stayed at 20. The group with moderate exercise got worse by 1.5 points. The group that did not exercise worsened by three points. Three points out of a score of 20 points is a 15 percent change in the primary signs of the disease and considered clinically important to patients. It makes a difference in their quality of life. (NEXT) Meditation adapts the brain to respond better to feedback University of Surrey UK, December 11, 2022 In a study in the Journal of Cognitive, Affective & Behavioral Neuroscience researchers from the University of Surrey have discovered a link between meditation and how individuals respond to feedback. Participants in the study, a mixture of experienced, novice and non-meditators, were trained to select images associated with a reward. Each pair of images had varying probabilities of a reward e.g. images that result in a reward 80 per cent of the time versus those that result in a reward 20 per cent of the time. Participants eventually learnt to select the pairing with the higher outcome. Researchers found that participants who meditated were more successful in selecting high-probability pairings indicating a tendency to learn from positive outcomes, compared to non – meditators who learned the pattern via low-probability pairings suggesting a tendency to learn from negative outcomes. During the study participants were connected to an EEG, a non-invasive method that records electrical patterns in the brain. Results from the EEG found that while all three groups responded similarly to positive feedback, the neurological response to negative feedback was highest in the non-meditation group, followed by the novice group and then by the experienced meditation group. These results indicate that the brains of meditators are less affected by negative feedback, and that this may be a result of altered dopamine levels caused by meditation. Paul Knytl, lead author and PhD candidate in psychology at the University of Surrey, said: “Humans have been meditating for over 2000 years, but the neural mechanisms of this practice are still relatively unknown. These findings demonstrate that, on a deep level, meditators respond to feedback in a more even-handed way than non-meditators, which may help to explain some of the psychological benefits they experience from the practice.” (NEXT) Caution to pregnant women on red meat diabetes link University of Adelaide (Australia) December 12, 2022 Pregnant women and women planning to become pregnant can make use of the holiday season to adjust their diets and reduce the risk of gestational diabetes, according to researchers at the University of Adelaide's Robinson Institute. The recommendation comes at a time when there is increasing evidence to suggest that red meat is linked with a higher rate of gestational diabetes in pregnant women, which poses risks to the health of both the mother and the baby. In a commentary published in the jjournal Evidence-Based Nursing, author Philippa Middleton says the latest international research shows that women who eat a lot of red and processed meats even before they become pregnant have a significant risk of developing gestational diabetes. “There have been several reports linking red meat with increased risk of type 2 diabetes, and now the work of a number of research teams worldwide is showing this link for diabetes during pregnancy,” says Ms Middleton, who is one of the Robinson Institute's research leaders. “While this news is alarming, there are also some positives. The latest research from the United States has shown that eating fish and poultry does not increase the risk of gestational diabetes, and consuming more vegetable and non-meat protein is associated with a reduction in risk. “For example, just over half a serving of nuts per day can reduce the risk of gestational diabetes by 40%.” “Based on current evidence, pregnant women or women planning to become pregnant should consider eating more vegetable protein, and nuts, and replacing some red meat with fish and poultry. (NEXT) Treatment for lupus may depend on restoring proteins in patients' blood Singapore General Hospital, December 19, 2022 Restoring protein balance in the blood may be key to developing an effective treatment for lupus. The incurable autoimmune disease reportedly affects about 100 in every 100,000 people worldwide, and disproportionally affects women between 15 and 45 years-old and Asians. Lupus causes the body's immune system to attack itself, which can inflame several vital organs like the kidneys, brain, heart, and lungs. The aggressive nature of the disease is what makes it life-threatening for many who have it, especially since current treatments don't help that much. “We are excited about the possibility of a new treatment option for lupus as 30 to 60 percent of patients do not respond to conventional medications despite aggressive regimens. In the past 65 years, only three drugs for lupus have been approved by the United States Food and Drug Administration but these drugs have modest efficacy. There is therefore a real and urgent need for better therapies, particularly for the more severe spectrum of lupus that we see in Asia,” says senior author Andrea Low, the Head and Senior Consultant in the Department of Rheumatology & Immunology at Singapore General Hospital (SGH), in a media release. To reach their findings, Low and her team studied CXCL5, a protein that helps to regulate the immune system through neutrophils, which are a type of white blood cell. They revealed that lupus patients had considerably lower levels of the protein in their blood compared to healthy people, thus suggesting that it may have a connection to the disease. They also discovered that mice with severe lupus injected weekly with CXCL5 displayed restored protein balance. Moreover, their survival outcomes increased from 25 percent to over 75 percent after 10 weeks. Not only did the injections reduce mortality risk, but they didn't cause any adverse side-effects, study authors report. “Our study has shown CXCL5 to be safe. There was no liver or kidney toxicity or cancer inducing effects. Major components of the immune system were also not compromised,” reports principal investigator Dr Fan Xiubo, Senior Research Fellow, Department of Clinical Translational Research, SGH. The entire team is hopeful that they can continue to build on their research to better the lives of patient's suffering from this debilitating disease. “To be in the forefront of medicine means we have to constantly further our understanding of diseases and offer patients better treatment options through rigorous scientific research. I'm heartened that the team has shed new light on lupus and the possibility of a more efficacious therapy for patients some years down the road,” says Professor Fong Kok Yong, Deputy Group CEO (Medical and Clinical Services), SingHealth, and Senior Consultant, Department Rheumatology & Immunology, SGH

Videos: 6 minutes ago : Elon Musk Shared Terrifying Message (8:39) You're Not Going To Believe This! | Mark Steyn & Eva Vlaardingerbroek (3:03) Tulsi Gabbard News Live/ Tulsi Shares The True Reason Of Her Exit (3:13) Neil Oliver – ‘…it's a toxic hell…' (START @ 9:00) So THIS is how they plan to screw these companies, from inside out | Redacted with Clayton Morris (2:48)   Pomegranate juice found to combat systemic inflammation throughout the body University of Bologna (Italy) & University of Auckland (New Zealand), November 18, 2022 The researchers from the University of Bologna and the University of Auckland looked at the effects of the juice of the pomegranate in particular, which has already been shown to help conditions like diabetes, atherosclerosis and prostate cancer. Chronic inflammation, a response by the body to infection and tissue damage, has been linked to the development of disorders such as inflammatory bowel disease, asthma, rheumatoid arthritis, chronic obstructive pulmonary disease and psoriasis. After analyzing an extensive number of existing studies on pomegranate, they found plenty of evidence that shows pomegranate juice can indeed help inflammation-related diseases, although they pointed out that a definitive relationship has not been officially established. Most of the scientific research on pomegranate's health benefits has been carried out on cell culture or animal models, they point out, and clinical trials with humans are generally lacking. They found that pomegranate seems to show the most promise in fighting cardiovascular diseases, metabolic syndrome and diabetes, but the researchers urge care, calling on further studies to determine its specific effects and explain why the fruit juice seems to help chronic inflammatory diseases. A Case Western study published in the Journal of Inflammation, for example, found that the extract of pomegranate significantly inhibited the buildup of damaging proteins associated with Alzheimer's disease by as much as a half. This effect is being attributed to its ability to protect against the oxidative stress that leads to beta-amyloid deposits. Researchers have also demonstrated its potential to help those with prostate, colon and breast cancer. In studies where tumor cells were treated with pomegranate, cell migration dropped and the cancer was stopped from spreading to other areas of the body. Pomegranate juice came out on top in a study of beverages known for their antioxidant content carried out by the Center for Human Nutrition at the University of California – Los Angeles's David Geffen School of Medicine. While all of the beverages examined – blueberry juice, acai berry juice, green tea, white tea, Concord grape juice, orange juice, pomegranate juice and red wine, had impressive amounts of antioxidants, pomegranate juice outperformed them all when it came to polyphenols and protective benefits. Its antioxidant potency composite index was a full 20 percent higher than any of the other drinks that were put through the rigorous testing. (NEXT) Handful of walnuts daily cuts risk of asthma University of North's Carolina, November 20, 2022 Here's another reason for you to eat more walnuts as a type of vitamin E, found in these nuts, may prevent the risk of asthma attacks by reducing airway inflammation. According to researchers, sufferers of a common breathing condition, taking it as part of the study, were also found to have less sticky mucus in their lungs. Gamma-tocopherol is a major form of vitamin E, which is abundant in nuts like walnuts and pecans and in the legume peanut, as well as seed oils such as corn, soybean and sesame. Senior study author Professor Michelle Hernandez from the University of North's Carolina school of medicine said epidemiologic data suggested that people with high amounts of vitamin E in their diet were less prone to asthma and allergic disease. The team randomly analysed participants into two groups, one that received gamma tocopherol supplement and other that received a placebo for two weeks. After a three-week period break, the findings indicated that when people were taking the vitamin E supplement, they had less eosinophilic inflammation. In addition, those who were taking vitamin E were also found to have lower levels of proteins called mucins, which affect the stickiness of mucus. Mucins are often elevated in asthmatics. (NEXT) Using vapes may set the stage for dental decay Tufts University, November 23, 2022 A vaping habit could end up leading to a tarnished smile, and more frequent visits to the dentist. Research by faculty from Tufts University School of Dental Medicine found patients who said they used vaping devices were more likely to have a higher risk of developing cavities. With CDC surveys reporting that 9.1 million American adults—and 2 million teenagers—use tobacco-based vaping products, that means a lot of vulnerable teeth. The findings of this study on the association between vaping and risk of caries—the dental term for cavities—serve as an alert that this once seemingly harmless habit may be very detrimental, says Karina Irusa, assistant professor of comprehensive care and lead author on the paper. The study was published in The Journal of the American Dental Association. Irusa says that the recent Tufts finding may be just a hint of the damage vaping causes to the mouth. “The extent of the effects on dental health, specifically on dental decay, are still relatively unknown,” she says. “At this point, I'm just trying to raise awareness,” among both dentists and patients. This study, Irusa says, is the first known specifically to investigate the association of vaping and e-cigarettes with the increased risk for getting cavities. She and her colleagues analyzed data from more than 13,000 patients older than 16 who were treated at Tufts dental clinics from 2019-2022. While the vast majority of the patients said they did not use vapes, there was a statistically significant difference in dental caries risk levels between the e-cigarette/vaping group and the control group, Irusa found. Some 79% of the vaping patients were categorized as having high-caries risk, compared to just about 60% of the control group. The vaping patients were not asked whether they used devices that contained nicotine or THC, although nicotine is more common. It's also been observed that vaping seems to encourage decay in areas where it usually doesn't occur—such as the bottom edges of front teeth. “It takes an aesthetic toll,” Irusa says. (NEXT) Study finds link between foods scored higher by new nutrient profiling system and better long-term health outcomes Tufts University, November 22, 2022 The idea that what we eat directly affects our health is ancient; Hippocrates recognized this as far back as 400 B.C. But, identifying healthier foods in the supermarket aisle and on restaurant menus is increasingly challenging. Now, researchers at the Friedman School of Nutrition Science and Policy at Tufts have shown that a holistic food profiling system, Food Compass, identifies better overall health and lower risk for mortality. In a paper published in Nature Communications, researchers assessed whether adults who ate more foods with higher Food Compass scores had better long-term health outcomes and found that they did. Introduced in 2021, Food Compass provides a holistic measure of the overall nutritional value of a food, beverage, or mixed meal. It measures nine domains of each item, such as nutrient ratios, food-based ingredients, vitamins, minerals, extent of processing, and additives. Based on scores of 10,000 commonly consumed products in the U.S., researchers recommend foods with scores of 70 or above as foods to encourage; foods with scores of 31-69 to be eaten in moderation; and anything that scores 30 or below to be consumed sparingly. For this new study, Food Compass was used to score a person's entire diet, based on the Food Compass scores of all the foods and beverages they regularly consume. For this validation study, researchers used nationally representative dietary records and health data from 47,999 U.S. adults aged 20-85 who were enrolled between 1999-2018 in the National Health and Nutrition Examination Survey (NHANES). Deaths were determined through linkage with the National Death Index (NDI). Overall, researchers found that the mean Food Compass score for the diets of the nearly 50,000 subjects was only 35.5 out of 100, well below ideal. “One of the most alarming discoveries was just how poor the national average diet is,” said O'Hearn. “This is a call for actions to improve diet quality in the United States.” A higher Food Compass diet score was associated with lower blood pressure, blood sugar, blood cholesterol, body mass index, and hemoglobin A1c levels; and lower prevalence of metabolic syndrome and cancer. A higher Food Compass diet score was also associated with lower risk of mortality: for each 10-point increase, there was a 7 percent lower risk of death from all causes. Food Compass also boosts scores for ingredients shown to have protective effects on health, like fruits, non-starchy vegetables, beans and legumes, whole grains, nuts and seeds, seafood, yogurt, and plant oils; and lowers scores for less healthful ingredients like refined grains, red and processed meat, and ultra-processed foods and additives. “We know Food Compass is not perfect,” said Mozaffarian. “But, it provides a more comprehensive, holistic rating of a food's nutritional value than existing systems, and these new findings support its validity by showing it predicts better health.” (NEXT) Acupuncture can relieve lower back and pelvic pain often experienced during pregnancy Guangzhou University of Chinese Medicine, November 21, 2022 Acupuncture can significantly relieve the lower back and/or pelvic pain frequently experienced by women during their pregnancy, suggests a pooled data analysis of the available evidence, published in BMJ Open. And there were no observable major side effects for newborns whose moms opted for the therapy, the findings indicate, although only a few of the published studies included in the analysis evaluated outcomes, such as premature birth, note the researchers. To add to the evidence base, the researchers trawled research databases for relevant clinical trials that compared the pain relief afforded to pregnant womengiven acupuncture, alone or when combined with other therapies, with other/no/dummy treatments, as well as the potential impact on their newborns. The final analysis included 10 randomized controlled trials, involving 1,040 women. Every study was published between 2000 and 2020, and carried out variously in Sweden, the UK, the U.S., Spain and Brazil. The moms-to-be were all healthy, 17 to 30 weeks into their pregnancy on average, and had lower back and/or pelvic pain. Pooled data analysis of the trial results for nine studies suggested that acupuncture significantly relieved pain during pregnancy. Four of those studies reported on the potential of acupuncture to restore physical function, and the results showed that this was significantly improved. Quality of life was recorded in five studies. When the results of these were pooled, the findings suggested that acupuncture significantly improved this too. Pooled data analysis of four studies indicated that there was a significant difference in overall effects when acupuncture was compared with other or no interventions. The researchers conclude that acupuncture merits closer attention for its potential to ease pain at a time when it's preferable to avoid drugs because of their potential side effects for mother and baby. (NEXT) 6 Health Benefits Of Rutin, And Where To Find It GreenMedInfo, November 24, 2022 Rutin is an antioxidant and anti-inflammatory powerhouse found in a variety of delicious food that may boost your health via multiple avenues, from promoting healthy circulation to providing pain relief. Rutin is one of about 4,000 types of flavonoids that are found abundantly in plants. Also known as rutoside and vitamin P, rutin is a flavonol that acts as an active constituent in tea leaves, apples, buckwheat, most citrus fruits and passion flower, for example, with nutraceutical effects that have been valued since ancient times. Medicinal plant compounds often have a range of biological activities that are both impressive and varied. Rutin is no exception, with a number of pharmacological activities that include: Six Top Reasons to Try Rutin Rutin is perhaps best known for its ability to ward off oxidative stress via potent antioxidant properties. This makes it valuable in a number of disease conditions and even as a tool for healthy aging. Rutin, for instance, reduces skin aging by strengthening dermal density and elasticity, and is found in more than 130 registered therapeutic medicinal preparations. GreenMedInfo.com has additionally compiled nearly 70 pharmacological actions related to rutin, along with 136 diseases that it may be useful for. Some of its top health benefits follow. Protection From Neurodegenerative Disease Rutin has demonstrated benefits to the central nervous system, including prevention of neuroinflammation, anticonvulsant activity and antidepressant effects. Rutin may be useful for recovery after stroke and also shows promise for Alzheimer's disease. With an ability to cross the blood-brain barrier, rutin may benefit the cognitive and behavioral symptoms of neurodegenerative diseases and helps to remove the inflammatory component of neurodegeneration. Relieve Arthritis Pain Rutin not only has analgesic and antinociceptive effects but also antiarthritic effects, making it an ideal natural option for arthritis.The plant compound has been found to suppress oxidative stress in people with rheumatoid arthritis,while also inhibiting both the acute and chronic phases of inflammation in an arthritis rat model. Antidiabetic Effects Rutin has beneficial effects on the endocrine system, including antidiabetic and anti-hypercholesterolemic effects. Rutin helps fight diabetes by decreasing carbohydrates absorption from the small intestine, increasing the uptake of glucose into tissues and stimulating the secretion of insulin from beta cells, leading to antihyperglycemic effects as well as protection against the development of diabetic complications. Rutin is also useful for protecting against age-related metabolic dysfunction, with research suggesting it inhibits age-related mitochondrial dysfunction and oxidative stress, as well as endoplasmic reticulum, or ER, stress, which is related to proteins that are not properly folded. Promote Healthy Circulation and Reduce Blood Clots Consuming rutin, either from foods or supplements, may be an effective way to block the formation of blood clots. Research by Harvard Medical School researchers suggests that rutin is effective against both platelet-rich clots that form in arteries and fibrin-rich clots that form in veins. Rutin was found to be a “champion compound” for inhibiting protein disulfide isomerase (PDI), which plays a role in the initial stages of clot formation. A nano-formulation of rutin was also found to exert powerful antithrombotic effects by inhibiting PDI,while rutin may also augment the production of nitric oxide in human endothelial cells, which is useful for blood pressure and cardiovascular system health. In terms of improved circulation, rutin is a venoactive compound, which means it may be useful for symptoms of chronic venous diseases (CVD). The compound has been demonstrated to reduce severity of lower leg pain, leg cramps, heaviness and itching, as well as edema (swelling), in people with CVD. Anticancer Effects Rutin's anticancer properties have been extensively studied. In human leukemia cells, rutin led to a significant reduction in tumor size, and it's known to inhibit cancer cell growth by cell cycle arrest and apoptosis. It also inhibits proliferation and metastasis of colorectal cancer cell lines and shows promise for use in ovarian and color cancers, as well as neuroblastoma. Support Gastrointestinal Health Rutin has antiulcer effects, as it inhibits the gastric proton pump that sends acid to your stomach. It also has potential against inflammatory bowel disease, not only due to its antioxidant effects but also by suppressing the release of proinflammatory mediators and the expression of inflammatory proteins. Top Sources of Rutin As noted in the Saudi Pharmaceutical Journal, “An ancient saying ‘an apple a day, keeps doctor away' seems to be true as rutin, one of the important constituents of apples, has a wide array of biological activities.”

VIDEOS: Mark Dolan: Covid has been the biggest “I told you so” in history (4:41) Society is going to COLLAPSE (5:24) Fear Psychosis and the Cult of Safety – Why are People so Afraid? (13:25) MSNBC Midterm PANIC꞉ ‘It's Going To Be a BLOODBATH'!!! (0:18 – 3:32) Pycnogenol, gotu kola supplementation associated with decreased progression of atherosclerosis D'Annunzio University (Italy), October 23, 2022 The results of studies published in Minerva Cardioangiologica suggest a benefit for supplementation with extracts of pine bark and the herb gotu kola in atherosclerosis. In one study, participants with arterial wall atherosclerotic lesions and intima-media thickening (thickening of the artery walls' innermost layers) received standard management, standard management plus aspirin, or standard management, aspirin and Pycnogenol® pine bark extract plus gotu kola extract daily for three years, after which atherosclerotic lesion progression, carotid artery intima-media thickness and oxidative stress were assessed. At the end of the trial, 5.3% of those who received Pycnogenol and gotu kola had experienced atherosclerotic lesion progression in comparison with over 20% of the remainder of the participants. Cardiovascular events that required hospital admission were less than 4% in the supplemented group compared to over 12% in the rest of the subjects. Carotid artery intima thickness and oxidative stress were also lower in association with supplementation. In the second study, 90 men with coronary artery calcifications received standard management alone, standard management and daily Pycnogenol, or standard management with daily Pycnogenol plus gotu kola. All participants received daily aspirin. Calcification was assessed at the beginning of the study and after one year. While Pycnogenol plus standard management was more effective than standard management alone, men who received Pycnogenol plus gotu kola experienced a 10% decline in the number of calcifications by the end of the study, in contrast with a 34.9% increase in the standard management group. “This indicates that supplementation with the combined supplements blocks the increase in calcified areas and, possibly, in time may decrease the number of calcified spots,” Shu Hu and colleagues write. Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study. Pennsylvania State University, October 22, 2022 Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms. We evaluated the effects of 2 doses of pistachios, added to a lower-fat diet, on lipids and lipoproteins, apolipoprotein (apo)-defined lipoprotein subclasses, and plasma fatty acids. To investigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD). In a randomized crossover controlled-feeding study, 28 individuals with LDL cholesterol > or = 2.86 mmol/L consumed 3 isoenergetic diets for 4 wk each. Baseline measures were assessed after 2 wk of a typical Western diet. The experimental diets included a lower-fat control diet with no pistachios [25% total fat; 8% saturated fatty acids (SFAs), 9% monounsaturated fatty acids (MUFAs), and 5% polyunsaturated fatty acids (PUFAs)], 1 serving/d of a pistachio diet (1 PD; 10% of energy from pistachios; 30% total fat; 8% SFAs, 12% MUFAs, and 6% PUFAs), and 2 servings/d of a pistachio diet (2 PD; 20% of energy from pistachios; 34% total fat; 8% SFAs, 15% MUFAs, and 8% PUFAs). Inclusion of pistachios in a healthy diet beneficially affects CVD risk factors in a dose-dependent manner, which may reflect effects on SCD. Poor quality sleep may be linked to heightened risk of glaucoma, irreversible sight loss Sichuan University (China), November 1, 2022 Poor quality sleep, including too much or too little shuteye, daytime sleepiness, and snoring, may be linked to a heightened risk of developing irreversible sight loss (glaucoma), suggests a large UK Biobank study published in the open access journal BMJ Open. The findings underscore the need for sleep therapy in people at high risk of the disease as well as eye checks among those with chronic sleep disorders to check for early signs of glaucoma, conclude the researchers. While population screening may not be cost-effective, targeted screening of high-risk groups might be, suggest the researchers. And previously published research suggests that sleep disorders may be an important risk factor. To explore these issues further, the researchers set out to ascertain the risk of glaucoma among people with different sleep behaviors: insomnia; too much or too little sleep; night or morning chronotypes (“owls” or “larks”); daytime sleepiness; and snoring. They drew on 409,053 participants in the UK Biobank, all of whom were aged between 40 and 69, and who had provided details of their sleep behaviors. Sleep duration of 7 to less than 9 hours per day was defined as normal, and as too little or too much outside this range. Chronotype was defined according to whether the person described themselves as more of a morning lark or night owl. During an average monitoring period of just over 10.5 years, 8690 cases of glaucoma were identified. Those with glaucoma tended to be older and were more likely to be male, chronic smokers, and to have high blood pressure or diabetes than those who weren't diagnosed with the disease. Short or long sleep duration was associated with a heightened risk of 8%; insomnia, 12%; snoring, 4%; and frequent daytime sleepiness, 20%. Compared to those with a healthy sleep pattern, snorers and those who experienced daytime sleepiness were 10% more likely to have glaucoma, while insomniacs and those with a short/long sleep duration pattern were 13% more likely to have it. Could a Japanese mushroom extract eradicate HPV? University of Texas Health Science Center October 29, 2022 A study by researchers from The University of Texas Health Science Center suggests that an extract from a Japanese mushroom has potential to eradicate human papillomavirus – the leading cause of cervical cancer. HPV is also accountable for around 95% of anal cancers, 65% of vaginal cancers, 60% of oropharyngeal cancers, 50% of vulvar cancers and 35% of penile cancers. . As such, the team set out to assess the effects of active hexose correlated compound (AHCC) against HPV. AHCC is a substance produced by the shiitake mushroom, also called the Japanese mushroom, native to Asia. AHCC is already available as a nutritional supplement, hailed for its immune-boosting properties. Previous studies, however, have suggested that the compound may improve the growth and function of cells that ward off infections and prevent tumor growth. To reach their findings, Smith and colleagues enrolled 10 women to their study who had tested positive for HPV infection. Once a day for up to 6 months, each woman took an oral formulation of AHCC. Five of these women tested negative for HPV infection after 3 months of AHCC use. Among three of the participants, it was confirmed that HPV had been completely eradicated after AHCC use had ceased. The remaining two women needed to take AHCC for the full 6 months to see results. The team's findings are “very encouraging,” according to Smith. “We were able to determine that at least 3 months of treatment is necessary, but some need to extend that to 6 months,” she says, adding: “Since AHCC is a nutritional supplement with no side effects and other immune-modulating benefits, we will be planning on using 6 months of treatment in our phase 2 clinical study to have a consistent study treatment plan. This confirms our earlier preclinical research.” Research suggests higher testosterone reference range for young men University of Michigan, October 31 2022. In an article appearing in the Journal of Urology, Alex Zhu , of University of Michigan and his associates asserted that the standard cutoff for testosterone deficiency of 300 nanograms per deciliter (ng/dL) is too low for men younger than 45 years of age. The study is “the first evaluation of normative, population-based testosterone levels for young men in the United States,” according to Dr Zhu and colleagues. “There is an age-related decline in male testosterone production,” they wrote. “It is therefore surprising that young men are evaluated for testosterone deficiency with the same cutoff of 300 ng/dL that was developed from samples of older men.” The investigation included 1,486 men between the ages of 20 to 44 years who participated in the National Health and Nutrition Examination Surveys (NHANES) of United States residents. Men who were receiving hormone replacement therapy were excluded from the study. The men's testosterone levels were evaluated according to 5-year age groups. Testosterone levels that fell in the middle one-third of each group were categorized as normal. For every 1-year increase in age, a 4.3 ng/dL decline in testosterone was observed. Normal levels of testosterone for men aged 20 to 24 years were categorized as 409-558 ng/dL, for those 25-29 as 413-575 ng/dL, for men 30 to 34 as 359-498 ng/dL, for 35-39-year-olds as 352-478 ng/dL and for 40 to 44-year-olds as 350-473 ng/dL. This resulted in age-specific cutoffs for low testosterone levels of 409, 413, 359, 352 and 350 ng/dL for each age group. “Young men have different testosterone reference ranges than older men,” Dr Zhu, remarked. “Our findings suggest we should be using age-specific cutoffs when assessing testosterone levels in younger men.” Why 80% of Us Are Deficient In Magnesium Dr Mark Sircus, October 31st 2022 Magnesium deficiency is often misdiagnosed because it does not show up in blood tests – only 1% of the body's magnesium is stored in the blood Most doctors and laboratories don't even include magnesium status in routine blood tests. Thus, most doctors don't know when their patients are deficient in magnesium, even though studies show that the majority of Americans are deficient in magnesium. Consider Dr. Norman Shealy's statements, “Every known illness is associated with a magnesium deficiency” and that, “magnesium is the most critical mineral required for electrical stability of every cell in the body. A magnesium deficiency may be responsible for more diseases than any other nutrient.” Few people are aware of the enormous role magnesium plays in our bodies. Magnesium is by far the most important mineral in the body. After oxygen, water, and basic food, magnesium may be the most important element needed by our bodies; vitally important, yet hardly known. It is more important than calcium, potassium or sodium and regulates all three of them. Millions suffer daily from magnesium deficiency without even knowing it Symptoms of Magnesium Deficiency The first symptoms of deficiency can be subtle – as most magnesium is stored in the tissues, leg cramps, foot pain, or muscle ‘twitches' can be the first sign. Other early signs of deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur. Symptoms involving impaired contraction of smooth muscles include constipation; urinary spasms; menstrual cramps; difficulty swallowing or a lump in the throat-especially provoked by eating sugar; photophobia, especially difficulty adjusting to oncoming bright headlights in the absence of eye disease; and loud noise sensitivity from stapedius muscle tension in the ear. Continuing with the symptoms of magnesium deficiency, the central nervous system is markedly affected. Symptoms include insomnia, anxiety, hyperactivity and restlessness with constant movement, panic attacks, agoraphobia, and premenstrual irritability. “Symptoms or signs of the cardiovascular system include palpitations, heart arrhythmias, and angina due to spasms of the coronary arteries, high blood pressure and mitral valve prolapse. Be aware that not all of the symptoms need to be present to presume magnesium deficiency; but, many of them often occur together. One of the principle reason doctors write millions of prescriptions for tranquilizers each year is the nervousness, irritability, and jitters largely brought on by inadequate diets lacking magnesium. Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent. If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given. Another good list of early warning symptoms suggestive of magnesium insufficiency: Physical and mental fatigue Persistent under-eye twitch Tension in the upper back, shoulders and neck Headaches Pre-menstrual fluid retention and/or breast tenderness Possible manifestations of magnesium deficiency include: Low energy Fatigue Weakness Confusion Nervousness Anxiousness Irritability Seizures (and tantrums) Poor digestion PMS and hormonal imbalances Inability to sleep Muscle tension, spasm and cramps Calcification of organs Weakening of the bones Abnormal heart rhythm Signs of severe magnesium deficiency include: Extreme thirst Extreme hunger Frequent urination Sores or bruises that heal slowly Dry, itchy skin Unexplained weight loss Blurry vision that changes from day to day Unusual tiredness or drowsiness Tingling or numbness in the hands or feet Frequent or recurring skin, gum, bladder or vaginal yeast infections Magnesium deficiency is a predictor of diabetes and heart disease both; diabetics both need more magnesium and lose more magnesium than most people. In two new studies, in both men and women, those who consumed the most magnesium in their diet were least likely to develop type 2 diabetes

Are benzos effective for treating anxiety? Insomnia? Seizures? If they aren't safe, what is the evidence? How many BIND symptoms are there? Could these be permanent? And what about COVID? Tune in for the surprising answers.In today's episode, we ask some key questions about benzos and provide real answers, with evidence to back them. We also share questions from our international listeners on CBD and probiotics, and we hear a powerful story of one woman's struggle with her third attempt at withdrawal. This one if chock full of information, and I hope you'll join us.https://www.easinganxiety.com/post/the-facts-what-do-we-really-know-about-benzos-and-bind-bfp107Video ID: BFP107Chapters 0:00:00 INTRODUCTION0:01:16 About the Last Episode0:02:17 Behind the Scenes Work0:03:18 Hurricane Ian0:05:38 MAILBAG0:05:54 Benzo Belly and Probiotics (Jon)0:11:48 CBD and Withdrawal (Julie)0:17:29 BENZO STORY (Jessica)0:26:48 Response from D0:31:20 FEATURE: Benzo Facts0:32:48 Are Benzos Effective?0:35:23 Are Benzos Safe?0:43:49 Can You Be Addicted to Benzos?0:44:46 Is BIND an Official Term?0:47:21 How Many BIND Symptoms Are There?0:52:05 Is BIND Permanent?0:56:42 Are Z-drugs the Same as Benzos?0:57:22 Do Benzos Have an Effect on COVID?1:00:58 MOMENT OF PEACE Episode Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Easing Anxiety of the resource or any recommendations or advice provided therein.SITE RESOURCES— Benzodiazepine Action Work Group (BAWG) — https://benzoaction.org— Benzodiazepine Information Coalition (BIC) — https://benzoinfo.com— The Alliance for Benzodiazepine Best Practices — https://benzoreform.org— Blazing Benzos Facebook Group — https://m.facebook.com/groups/1205287192817668/MAILBAGGrinspoon, Peter. Cannabidiol (CBD): What we know and what we don't. Harvard Health Publishing. September 24, 2021. Accessed September 27, 2022. https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476. FEATUREAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual. Ashton, C. Heather. Benzodiazepines: The Still Unfinished Story. (Speech at Beat the Benzos Launch Conference, Croyden, London, England). https://www.benzo.org.uk/ashspeech.htm. Bachhuber, Marcus A., Sean Hennessy, Chinazo O. Cunningham and Joanna L. Starrels. “Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013.” American Journal of Public Health (AJPH) (April 2016). Accessed April 7, 2018. doi:10.2105/AJPH.2016.303061. Benzodiazepine Information Coalition (BIC). Withdrawal & Post Withdrawal Symptoms. Accessed September 29, 2022. https://www.benzoinfo.com/benzodiazepine-withdrawal-post-withdrawal-symptoms/. Breilmann J, Girlanda F, Guaiana G, Barbui C, Cipriani A, Castellazzi M, Bighelli I, Davies SJC, Furukawa TA, Koesters M. Benzodiazepines versus placebo for panic disorder in adults. Cochrane Database of Systematic Reviews 2019, Issue 3. Art. No.: CD010677. DOI: 10.1002/14651858.CD010677.pub2. Accessed 27 September 2022. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010677.pub2/full. Commonwealth of Pennsylvania. Prescribing Guidelines for Pennsylvania: Safe Prescribing Benzodiazepines for Acute Treatment of Anxiety & Insomnia. Updated May 15, 2017. Accessed April 7, 2018. http://www.health.pa.gov/My%20Health/Diseases%20and%20Conditions/M-P/opioids/Documents/PA%20Guidelines%20on%20Benzo%20Prescribing.pdf. Easing Anxiety. BIND Symptoms. https://easinganxiety.com/symptoms. Foster, D E. Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal. Erie, CO: Denim Mountain Press, 2018. https://easinganxiety.com/book. Frances, Allen. Yes, Benzos Are Bad for You. Pro Talk: A Rehabs.com Community. June 10, 2016. Accessed October 13, 2016. https://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/. Guina J, Merrill B. Benzodiazepines I: Upping the Care on Downers: The Evidence of Risks, Benefits and Alternatives. J Clin Med. 2018 Jan 30;7(2):17. doi: 10.3390/jcm7020017. PMID: 29385731; PMCID: PMC5852433. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852433/. Kripke, D. F., R.D. Langer and L.E. Kline. Hypnotics' Association with Mortality or Cancer: A Matched Cohort Study. BMJ Open 2(e000850)(2012). Accessed June 21, 2017. doi:10.1136/bmjopen-2012-000850. Lakhani, Nina, Drugs Linked to Brain Damage 30 Years Ago, Independent, November 7, 2010, accessed March 4, 2017, https://www.independent.co.uk/life-style/health-and-families/health-news/drugs-linked-to-brain-damage-30-years-ago-2127504.html. New York City Department of Health and Mental Hygiene (NYC DOHMH). City Health Information: Judicious Prescribing of Benzodiazepines. 35(2)(2016). https://docs.wixstatic.com/ugd/990dad_167113513c9445f8bc77a77370ce649f.pdf. Park, H.Y., Kwon, J., An, S.K. et al. A nationwide cohort study of the association of benzodiazepines with SARS-CoV-2 infection and clinical outcomes. Sci Rep 12, 15947 (2022). https://doi.org/10.1038/s41598-022-20335-z. U.S. Drug Enforcement Agency (DEA). Office of Diversion Control; Drug & Chemical Evaluation Section: Benzodiazepines (January 2013). Accessed March 6, 2017. https://www.deadiversion.usdoj.gov/drug_chem_info/benzo.pdf. U.S. Food & Drug Administration. FDA requiring Boxed Warning updated to improve safe use of benzodiazepine drug class. September 23, 2020. Accessed September 27, 2022. https://www.fda.gov/drugs/drug-safety-and-availability/fda-requiring-boxed-warning-updated-improve-safe-use-benzodiazepine-drug-class.  The PodcastThe Benzo Free Podcast provides information, support, and community to those who struggle with the long-term effects of anxiety medications such as benzodiazepines (Xanax, Ativan, Klonopin, Valium) and Z-drugs (Ambien, Lunesta, Sonata). WEBSITE: https://www.easinganxiety.comMAILING LIST: https://www.easinganxiety.com/subscribe YOUTUBE: https://www.youtube.com/@easinganx DISCLAIMERAll content provided by Easing Anxiety is for general informational purposes only and should never be considered medical advice. Any health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems, or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it. Please visit our website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. CREDITSMusic provided / licensed by Storyblocks Audio — https://www.storyblocks.com Benzo Free Theme — Title: “Walk in the Park” — Artist: Neil Cross PRODUCTIONEasing Anxiety is produced by… Denim Mountain Presshttps://www.denimmountainpress.com ©2022 Denim Mountain Press – All Rights Reserved

Welcome to this episode of Physician's Weekly podcast. I am your host, Dr. Rachel Giles, from Medicom Medical Publishers, in collaboration with Physician's Weekly. Today's episode features two interviews, with an inDEPTH look at prevention. First, we discuss primary prevention of HIV-AIDS from a community global approach, with Rachel Baggaley, MBBS, MSc, the team lead for testing, prevention, and populations in the Global HIV, Hepatitis and STI Programs at the WHO, who has recently published papers in the Lancet HIV and BMJ.  Our second interview is with Alan Pollack, MD, PhD, Chair and Professor of Radiation Oncology at the University of Miami's Sylvester Comprehensive Cancer Center. He talks us through his recently published trial in the Lancet about a new intervention for secondary prevention of prostate cancer after prostatectomy.Enjoy listening! Additional readingSchmidt H, et al. Lancet HIV. 2022;9(5):e363-e366.Kennedy C, et al. BMJ Open. 2022;12(2):e054121.  Pollack A, et al. Lancet. 2022 May 14;399(10338):1886-1901. 

A new study in the BMJ Open journal questions a long-held belief about longevity. CBS' Vicki Barker has more in today's "Reporter's Notebook."See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

For several years, data has validated the value of water immersion during labor (1st stage). However, when it comes to the 2nd stage of labor, the AAP and the ACOG are unified in their positions which is at odds with the ACNM. But what does the new data support? In this session we will cover a new systematic review and meta-analysis from BMJ Open which was published July 2022. Let's set the record straight on water immersion during the first and second stages of labor.

Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers perinatal psychiatry with Dr. Tuong Vi Nguyen, Assistant Professor, Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University and Scientist and Scientist, RI-MUHC, Brain Repair and Integrative Neuroscience (BRaIN) Program, Centre for Outcomes Research and Evaluation.    The learning objectives for this episode are as follows:   By the end of this episode, you should be able to… Define the field of perinatal psychiatry Describe the key issues that should be addressed in pre-conception psychiatric counseling Discuss the management approach for prescribing medications during pregnancy Recognize the prevalence of mood disorders during the perinatal period Recall the diagnostic criteria for postpartum depression Consider the risk factors and explanatory models for postpartum depression Discuss the use of screening tools for postpartum depression Outline the treatment for postpartum depression Describe the clinical presentation of postpartum psychosis and recognize the urgency of this condition List important risk factors for postpartum psychosis Discuss the management for postpartum psychosis   Guest: Dr. Tuong Vi Nguyen   Hosts: Nima Nahiddi (PGY4), Audrey Le (PGY1), and Arielle Geist (PGY2)    Produced by: Nima Nahiddi (PGY4), Audrey Le (PGY1), Rebecca Marsh (PGY2) and Arielle Geist (PGY2)    Audio editing by: Audrey Le   Show notes by: Arielle Geist    Interview content: Introduction - 00:00 Learning objectives - 00:43 Defining the field of perinatal psychiatry - 01:55 Key issues to address in preconception counseling - 02:50 Management approach for prescribing medications during pregnancy - 07:00 Prevalence of mood disorders during the perinatal period - 12:11 Diagnostic criteria for postpartum depression - 14:05 Differentiating postpartum psychosis from postpartum depression - 16:52 Risk factors and explanatory models for postpartum depression - 18:58 Screening tools for postpartum depression - 20:15 Treatment for postpartum depression - 22:13 Pharmacotherapy - 22:20 Psychotherapy - 27:34 Clinical presentation of postpartum psychosis - 29:07 Risk factors for postpartum psychosis - 30:43 Postpartum psychosis prognosis and impacts on attachment- 32:57 Management of postpartum psychosis -35:30 Closing comments - 38:00   Resources: Bérard, A., Zhao, J. P., & Sheehy, O. (2017). Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ open, 7(1), e013372. https://doi.org/10.1136/bmjopen-2016-013372 Boukhris, T., Sheehy, O., Mottron, L., & Bérard, A. (2016). Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. Jama Pediatrics, 170(2), 117-24. doi: 10.1001/jamapediatrics.2015.3356. Brown, A. S., Gyllenberg, D., Malm, H., McKeague, I. W., Hinkka-Yli-Salomäki, S., Artama, M., Gissler, M., Cheslack-Postava, K., Weissman, M. M., Gingrich, J. A., & Sourander, A. (2016). Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring. JAMA psychiatry, 73(11), 1163–1170. https://doi.org/10.1001/jamapsychiatry.2016.2594 Cohen, J. , Hernández-Díaz, S. , Bateman, B. , Park, Y. , Desai, R. , Gray, K. , Patorno, E. , Mogun, H. & Huybrechts, K. (2017). Placental Complications Associated With Psychostimulant Use in Pregnancy. Obstetrics & Gynecology, 130(6), 1192-1201. doi: 10.1097/AOG.0000000000002362. Huybrechts, K. F., Hernández-Díaz, S., Patorno, E., Desai, R. J., Mogun, H., Dejene, S. Z., Cohen, J. M., Panchaud, A., Cohen, L., & Bateman, B. T. (2016). Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations. JAMA psychiatry, 73(9), 938–946. https://doi.org/10.1001/jamapsychiatry.2016.1520 Huybrechts, K. F., Palmsten, K., Avorn, J., Cohen, L. S., Holmes, L. B., Franklin, J. M., Mogun, H., Levin, R., Kowal, M., Setoguchi, S., & Hernández-Díaz, S. (2014). Antidepressant use in pregnancy and the risk of cardiac defects. The New England Journal of Medicine, 370(25), 2397–2407. https://doi.org/10.1056/NEJMoa1312828 Imaz, M. L., Oriolo, G., Torra, M., Soy, D., García-Esteve, L., & Martin-Santos, R. (2018). Clozapine Use During Pregnancy and Lactation: A Case-Series Report. Frontiers in Pharmacology, 9, 264. https://doi.org/10.3389/fphar.2018.00264 Nörby, U., Forsberg, L., Wide, K., Sjörs, G., Winbladh, B., & Källén, K. (2016). Neonatal Morbidity After Maternal Use of Antidepressant Drugs During Pregnancy. Pediatrics, 138(5), e20160181. https://doi.org/10.1542/peds.2016-0181 Nörby, U., Winbladh, B., & Källén, K. (2017). Perinatal Outcomes After Treatment With ADHD Medication During Pregnancy. Pediatrics, 140(6), e20170747. https://doi.org/10.1542/peds.2017-0747 Reis, M., & Källén, B. (2013). Combined use of selective serotonin reuptake inhibitors and sedatives/hypnotics during pregnancy: risk of relatively severe congenital malformations or cardiac defects. A registered study. BMJ Open, 3, e002166. doi:10.1136/bmjopen-2012-002166 Sundram S. (2006). Cannabis and neurodevelopment: implications for psychiatric disorders. Human psychopharmacology, 21(4), 245–254. https://doi.org/10.1002/hup.762   References: Boland, R., Verduin, M., & Ruiz, P. (2021). Psychopharmacology. In Kaplan & Sadock's synopsis of psychiatry (Twelfth edition.). Philadelphia: Wolters Kluwer. Jones, I., Chandra, P.S., Dazzan, P., & Howard, L.K. (2014). Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period. Lancet, 384(9956), 1789-1799. doi: 10.1016/S0140-6736(14)61278-2. Nieldson, D., Videbech, P., Hedegaard, M., Dalby, J., & Secher, N.J. (2005). Postpartum depression: identification of women at risk. An International Journal of Obstetrics and Gynaecology, 107(10), 1210-1217. https://doi-org.myaccess.library.utoronto.ca/10.1111/j.1471-0528.2000.tb11609.x Schiller, C.E., Meltzer-Brody, S., & Rubinow, D.R. (2015). The role of reproductive hormones in postpartum depression. CNS Spectrums, 20(1), 48-59. doi: 10.1017/S1092852914000480 Viguera, A. (2021). Mild to moderate postpartum unipolar major depression: Treatment. UpToDate. Accessed 2021-01-18. Wisner, K.L., Sit, D.K.Y., & McShea, M.C. (2013). Onset timing, thoughts of self-harm, and diagnoses in postpartum women with screen-positive depression findings. JAMA Psychiatry, 70(5), 490-498. doi:10.1001/jamapsychiatry.2013.87   CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association. For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.

Researchers in Europe find that exercise habits in the year prior to COVID exposure decrease severity of symptoms. Crush your next workout or sauna session with the new Electrolyte Stix by MYOXCIENCE:  Use code podcast to save 15% OFF at checkout Link to show notes and video: https://bit.ly/3wiMcqZ Malisoux, L., et al (2022). Associations between physical activity prior to infection and COVID-19 disease severity and symptoms: results from the prospective Predi-COVID cohort study. BMJ Open, 12(4), e057863.  Time Stamps: 00:02 Physical activity is protective against both moderate and severe COVID 19-like illness. 01:00 People who are physically active are less likely to experience common classic symptoms. 01:53 Exercise is a key therapeutic intervention. It does not need to be structured recreational fitness. 03:45 There are now 7 studies showing that regular exercise and physical activity saves lives. 05:43 MET = Metabolic Equivalent Task. 06:15 Fewer than 30 MET hours per week means that you more likely to have moderate to severe symptoms. 09:45 80 MET hours per week garnered the fewest symptoms. 10:50 40 – 60 MET hours per week is ideal. 12:00 Even walking and gardening are protective. 12:40 There is reduced odds of death.  

How much do you know about benzos? About withdrawal? About anxiety and insomnia? Want to test that knowledge? Well, this is the place. It's time to lighten the mood a bit and have some fun. Welcome to our first-ever Benzo Trivia episode. In today's episode of the podcast, we ask the questions, and you provide the answers. I provide a series of questions in five separate categories related to benzos, allow you time to answer, and then provide the answers with a little background on each. I hope you enjoy it. https://www.easinganxiety.com/post/benzo-trivia-what-do-you-really-know-bfp085Video ID: BFP085 Chapters 00:00  Introduction 06:18 BENZO TRIVIA – Intro 08:49 Benzos, the Drug 16:50 Anxiety, Insomnia, and Benzos 21:30 The Benzo Community 24:51 Benzo Withdrawal 33:15 True or False: Rapid Fire 39:28 Closing  Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Easing Anxiety of the resource or any recommendations or advice provided therein. . FEATURE – BENZO TRIVIA American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders 4th ed. text rev. (DSM-IV-TR). Washington, DC: American Psychi-atric Association, 2000.Ashton, C. Heather. “Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual).” 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.Ashton, C. Heather. “Benzodiazepines: The Still Unfinished Story.” (Speech at Beat the Benzos Launch Conference, Croyden, London, England). https://www.benzo.org.uk/ashspeech.htm.Bachhuber, Marcus A., Sean Hennessy, Chinazo O. Cunningham and Joanna L. Starrels. “Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013.” American Journal of Public Health (AJPH) (April 2016). Accessed April 7, 2018. doi:10.2105/AJPH.2016.303061.Bowden, John. “CIA considered use of anti-anxiety drug in terror suspect interrogations: report.” The Hill. November 13, 2018. Accessed November 14, 2018. https://thehill.com/policy/defense/416485-cia-considered-potential-truth-serum-for-terror-suspects.Byrne, A. “Benzodiazepines: The End of a Dream.” Australian Family Physician 23(8)(Aug 1994):1584-5. Accessed April 17, 2018. https://www.ncbi.nlm.nih.gov/pubmed/7980158.Foster, D E. “Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal.” Erie, CO: Denim Mountain Press, 2018. https://easinganxiety.com/book.Frances, Allen. “Yes, Benzos Are Bad for You.” Pro Talk: A Rehabs.com Community, June 10, 2016. Accessed October 13, 2016. https://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/.Kripke, D. F., R.D. Langer and L.E. Kline. “Hypnotics' Association with Mortality or Cancer: A Matched Cohort Study.” BMJ Open 2(e000850)(2012). Accessed June 21, 2017. doi:10.1136/bmjopen-2012-000850.New York City Department of Health and Mental Hygiene (NYC DOHMH). City Health Information: Judicious Prescribing of Benzodiazepines 35(2)(2016). https://docs.wixstatic.com/ugd/990dad_167113513c9445f8bc77a77370ce649f.pdf.Porter, Mark, “Addicted to Sleeping Pills? Try This Instead,” The Sunday Times, October 25, 2016, accessed March 4, 2017, https://www.thetimes.co.uk/article/dr-mark-porter-how-to-avoid-sleeping-tablet-addiction-shsrnpwsm.Riechmann, Deb. “CIA considered potential truth serum for terror suspects.” Associated Press. November 13, 2018. Accessed November 14, 2018. https://apnews.com/e4bc055b4fee4e0d9f47ab14adc2c173.Sharbaf Shoar N, Bistas KG, Saadabadi A. “Flumazenil.” [Updated 2020 Sep 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK470180/.The PodcastThe Benzo Free Podcast provides information, support, and community to those who struggle with the long-term effects of anxiety medications such as benzodiazepines (Xanax, Ativan, Klonopin, Valium) and Z-drugs (Ambien, Lunesta, Sonata). WEBSITE: https://www.easinganxiety.comMAILING LIST: https://www.easinganxiety.com/subscribe YOUTUBE: https://www.youtube.com/@easinganx DISCLAIMERAll content provided by Easing Anxiety is for general informational purposes only and should never be considered medical advice. Any health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems, or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it. Please visit our website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. CREDITSMusic provided / licensed by Storyblocks Audio — https://www.storyblocks.com Benzo Free Theme — Title: “Walk in the Park” — Artist: Neil Cross PRODUCTIONEasing Anxiety is produced by…Denim Mountain Presshttps://www.denimmountainpress.com ©2022 Denim Mountain Press – All Rights Reserved