Podcasts about bmj open

Ever feel like staying healthy today requires constant effort, planning, and discipline?You're not imagining it. Modern life is designed in ways that make health harder than it used to be. From ultra-processed foods and sedentary jobs to a culture built around convenience and constant access to calories, our environment often works against our biology.In this episode, we break down why maintaining your health today can feel like an uphill battle—and why that doesn't mean you're failing. It means you're navigating what public health researchers call an “obesogenic environment”: surroundings that make overconsumption easy and physical activity harder.You'll learn how changes in our food system, movement patterns, and daily routines have reshaped the health landscape—and most importantly, what you can do about it.In this episode:Why modern environments promote overeatingHow ultra-processed foods increase calorie intakeWhy sedentary lifestyles changed daily energy expenditureThe hidden role of convenience and “friction” in eating behaviorWhy health requires more intention todayFive practical strategies to make healthy choices easierThe goal isn't perfection—it's awareness and creating an environment that supports your health instead of working against it.You're not failing. You're navigating a system that wasn't built for human health. ReferencesBaumeister, R. F., et al. (1998). Ego depletion. Journal of Personality and Social Psychology. Ducrot, P., et al. (2017). Meal planning, diet quality and body weight. Int. Journal of Behavioral Nutrition and Physical Activity. Hall, K. D., et al. (2019). Ultra-processed diets increase calorie intake and weight gain. Cell Metabolism. Juul, F., et al. (2022). Ultra-processed food consumption and obesity in the U.S. American Journal of Clinical Nutrition. Levine, J. A. (2002). Non-exercise activity thermogenesis (NEAT). Proceedings of the Nutrition Society. Martínez Steele, E., et al. (2016). Ultra-processed foods and added sugars in the U.S. diet. BMJ Open. Matthews, C. E., et al. (2008). Sedentary behavior and health outcomes. American Journal of Epidemiology. Pontzer, H. (2015). Constrained energy expenditure model. Current Biology. Pontzer, H. (2021). Burn: New Research Blows the Lid Off How We Really Burn Calories. Swinburn, B., et al. (1999). Obesogenic environments. Preventive Medicine. Young, L. R., & Nestle, M. (2002). Expanding portion sizes. American Journal of Public Health.Support the showGet Weekly Health Tips: thrivehealthcoachllc.com Join the Thrive Collective Facebook group Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You!

Probiotics. They are often marketed as the end of all and be all for all our health issues. And they CAN do some real good. There is NO DOUBT a connection with overall heath and gut health…and NO ONE can deny that. But probiotics gets grey for some women's health issues. A new prospective, single-arm, non-blinded, multicenter study across 31 hospitals in Japan is making some pretty dramatic claims regarding oral probiotics and recurrent spontaneous preterm birth (ePUB). Can oral probiotics reduce spontaneous recurrent preterm birth? Listen in for details. 1. Prevention of Recurrent Spontaneous Preterm Delivery Using Probiotics: Results from a Prospective, Single-Arm, Multicenter Trial. PPP trial Collaborators et al.American Journal of Obstetrics & Gynecology, Volume 0, Issue 02. Grev J, Berg M, Soll R. Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2018 Dec 12;12(12):CD012519. doi: 10.1002/14651858.CD012519.pub2. PMID: 30548483; PMCID: PMC6516999.3. Jarde A, Lewis-Mikhael AM, Moayyedi P, Stearns JC, Collins SM, Beyene J, McDonald SD. Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018 Jan 8;18(1):14. doi: 10.1186/s12884-017-1629-5. PMID: 29310610; PMCID: PMC5759212.4. Othman M, Neilson JP, Alfirevic Z. Probiotics for preventing preterm labour. Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD005941. doi: 10.1002/14651858.CD005941.pub2. PMID: 17253567; PMCID: PMC9006117.5. Timing of Probiotic Milk Consumption During Pregnancy and Effects on the Incidence of Preeclampsia and Preterm Delivery: A Prospective Observational Cohort Study in Norway.6. Nordqvist M, Jacobsson B, Brantsæter AL, Myhre R, Nilsson S, Sengpiel V. Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway. BMJ Open. 2018 Jan 23;8(1):e018021. doi: 10.1136/bmjopen-2017-018021. PMID: 29362253; PMCID: PMC5780685.7. Gao Q, Sun Y, Qu Y, Li F, Li P. The effect of probiotic supplementation during pregnancy on pregnancy complications: An umbrella meta-analysis. Medicine (Baltimore). 2025 Dec 19;104(51):e46409. doi: 10.1097/MD.0000000000046409. PMID: 41430994; PMCID: PMC12727282.SPONSOR WEBSITE: Visit perspectivemedical.org to learn more about the Hemorrhage View C-Section Drape

Respiratory disease, including infections, affects one in five people in England and is the third biggest cause of death, with around 68,000 annual deaths.In this podcast Dr Thomas Round talks to Professor Paul Little, a GP and Professor of Primary Care Research at the University of Southampton about respiratory tract infections. They provide a discussion on the common presentations to primary care including symptoms and their duration, natural history, assessment (triage), red flags, treatment including best practice for the use of antibiotics (NNT and NNH, TARGET toolkit), point of care testing (CRP), the use of nasal sprays, encouraging at risk groups to receive vaccinations, continuation of hand washing, and the impact of stress on illness. They also offer top tips for everyday practice.Further reading: RCGP Essential Knowledge Update Hot Topic: Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care RCGP TARGET antibiotics toolkit hub Little P, Vennik J, Rumsby K, et al. Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care: a randomised, controlled, open-label, parallel-group trial. Lancet Respir Med. 2024 Aug;12(8):619-632.  Little P, Stuart B, Andreou P, et al. Primary care randomised controlled trial of a tailored interactive website for the self-management of respiratory infections (Internet Doctor). BMJ Open. 2016 Apr 20;6(4): e009769. RCGP Podcast FeedbackYour feedback plays a crucial role in helping us improve the CPD products and services we offer. We would be grateful if you could please complete our short RCGP Podcast Survey, which will take no more than 5 minutes to complete.

A lot of therapies address the context in which nonsuicidal self-injury (NSSI) and self-harm may occur, but only a few treatments have been designed to address NSSI specifically. In this episode, we dive into one of these treatments: Emotion Regulation Group Therapy (ERGT). Drs. Kim Gratz and Matthew Tull from the University of Toledo in Ohio walk us through in significant detail each of the 90-minute 14 sessions of ERGT. You can purchase their book "Acceptance-based emotion regulation therapy: A clinician's guide to treating emotion dysregulation and self-destructive behaviors using an evidence-based therapy drawn from ACT and DBT" on Amazon here or at New Harbinger Publications here.  Connect with Dr. Gratz on LinkedIn here and Dr. Tull here. Below are links to their research on ERGT referenced in this episode: Gratz, K. L., & Gunderson, J. G. (2006). Preliminary data on an acceptance-based emotion regulation group intervention for deliberate self-harm among women with Borderline Personality Disorder. Behavior Therapy, 37(1), 25-35. Gratz, K. L., & Tull, M. T. (2011). Extending research on the utility of an adjunctive emotion regulation group therapy for deliberate self-harm among women with borderline personality pathology. Personality Disorders: Theory, Research, and Treatment, 2(4), 316–326. Gratz, K. L., Tull, M. T., & Levy, R. (2014). Randomized controlled trial and uncontrolled 9-month follow-up of an adjunctive emotion regulation group therapy for deliberate self-harm among women with borderline personality disorder. Psychological Medicine, 44, 2099–2112. Gratz, K. L., Bardeen, J. R., Levy, R., Dixon-Gordon, K., L., & Tull, M. T. (2015). Mechanisms of change in an emotion regulation group therapy for deliberate self-harm among women with borderline personality disorder. Behaviour Research and Therapy, 65, 29-35. Sahlin, H., Bjureberg, J., Gratz, K. L., Tull, M. T., Hedman, E., Bjarehed, J., Jokinen, J., Lundh, L., Ljotsson, B., & Hellner, C. (2017). Emotion regulation group therapy for deliberate self-harm: A multi-site evaluation in routine care using an uncontrolled open trial design. BMJ Open, 7(10), e016220. Follow Dr. Westers on Instagram and Twitter (@DocWesters). To join ISSS, visit itriples.org and follow ISSS on Facebook and Twitter (@ITripleS). The Psychology of Self-Injury podcast has been rated #5 by Feedspot in their "Best 20 Clinical Psychology Podcasts" and by Welp Magazine in their "20 Best Injury Podcasts."

HEALTH NEWS   Can exercise turn back the clock on your brain? New study says yes Why leaving things unfinished messes with your mind Short-term, calorie-restrictive diet improves Crohn's disease symptoms Higher daylight exposure improves cognitive performance, study finds Breastfeeding may lower mums' later life depression/anxiety risks for up to 10 years after pregnancy     Can exercise turn back the clock on your brain? New study says yes AdventHealth Research Institute, January 13 2026 (Eurekalert) A simple, steady exercise routine may help your brain stay biologically younger, supporting clearer thinking, stronger memory, and a greater sense of whole-person well-being.   The study found that adults who followed a year-long aerobic exercise program had brains that appeared nearly a year “younger” than those who didn't change their activity levels.   Published in the Journal of Sport and Health Science, the study explored whether regular aerobic exercise could slow, or even reverse “brain age,” a magnetic resonance imaging (MRI)-based biomarker of how old your brain looks compared to your actual age. A higher brain-predicted age difference (brain-PAD), indicates an older-appearing brain and has been linked to poorer physical and cognitive function and increased risk of mortality in previous research.  In this clinical trial, 130 healthy adults aged 26–58 were randomly assigned to either a moderate-to-vigorous aerobic exercise group or a usual-care control group. The exercise group completed two supervised 60-minute sessions per week in a laboratory plus home-based exercise to reach about 150 minutes of aerobic activity per week, aligning with the American College of Sports Medicine's physical activity guidelines. Brain MRI and cardiorespiratory fitness, measured as peak oxygen uptake (VO2peak), were assessed at the beginning and end of the 12-month period.  Over 12 months, participants in the exercise group showed a measurable reduction in brain age, while the control group showed a slight increase. On average, the exercise group's brain-PAD decreased by about 0.6 years, indicating a younger-appearing brain at follow-up. In contrast, the control group's brains appeared about 0.35 years older, a change that was not statistically significant. Overall, the between-group difference in brain age was nearly one year, favoring the exercise group.     Why leaving things unfinished messes with your mind Yale University, January 12 2026 (Medical Xpress) In a new study, published in the Journal of Experimental Psychology: General, Yale professor of psychology Brian Scholl and lab members explored why humans so badly want to finish what we've started—in matters great and small. It turns out the brain just doesn't like dangling threads. The researchers had a hunch that visual clues could help explain the lure of the unfinished. Why is this state of leaving things undone so salient to us? It's an interesting quirk of human nature that science has not previously addressed. Unfinishedness has been found to decrease work satisfaction, impair sleep, and fuel ruminative thinking patterns. The researchers turned to the visual system. When we see unfinished events, are they somehow prioritized in memory?" To test their hunch that visual memory plays a role in making unfinishedness feel so sticky, the researchers ran four experiments involving a total of 120 participants who viewed computer animations of simple mazes populated by moving dots or lines. In several experiments, it seemed that the brain is wired to notice and remember incomplete things better than finished ones. The findings suggest that "unfinishedness" isn't just about motivation or satisfaction. It's built into the way people see and remember the world.   Short-term, calorie-restrictive diet improves Crohn's disease symptoms     Stanford University, January 13 2026 (News-Medical)   There have been few large studies of dietary interventions for IBD, a group of disorders that includes ulcerative colitis and Crohn's disease. Now a Stanford Medicine-led study finds a short-term, calorie-restrictive diet significantly improved symptoms. Their national, randomized controlled clinical trial found that a short-term, calorie-restrictive diet significantly improved both physical symptoms and biological indicators of mild-to-moderate Crohn's disease. A chronic condition affecting about a million Americans, Crohn's disease causes inflammation in the digestive tract, leading to symptoms of diarrhea, cramping, abdominal pain and weight loss. Steroids are the only approved therapeutic for mild Crohn's, but their use is limited due to significant side effects, particularly with long-term use. The study compared the symptoms and biological indicators of patients with mild-to-moderate Crohn's disease as they either followed a fasting mimicking diet or ate their normal diet for three consecutive months. The study enrolled 97 patients across the country, with 65 in the fasting mimicking group and 32 in the control group. Participants in the fasting mimicking group severely limited their calories for five consecutive days per month, eating between about 700 and 1,100 calories a day. Plant-based meals were provided during the fasting period. For the remainder of the month, the fasting mimicking group ate their normal diet. At the end of the study, two-thirds of the fasting mimicking group experienced improvement in their symptoms. The researchers found a significant decline in fecal calprotectin, a protein in the stool that indicates gut inflammation, in the fasting mimicking group compared with the control group. Some inflammation-promoting lipid mediators derived from fatty acids also declined in fasting mimicking group participants. Similarly, the immune cells of fasting mimicking group participants produced fewer of several types of inflammatory molecules.   Higher daylight exposure improves cognitive performance, study finds University of Manchester (UK), January 12 2026 (Medical Xpress) A real world study led by University of Manchester neuroscientists has shown that higher daytime light exposure positively influences different aspects of cognition. The first study of its kind showed that stable light exposure across a week and uninterrupted exposure during a day had similar effects. Participants in the study experienced improved subjective sleepiness, the ability to maintain focused attention and 7-10% faster reaction speeds under bright light when compared to recent dim conditions. Compared with their peers who went to bed later, participants with earlier bedtimes tended to be both more reliably wakeful under bright morning light and sleepy under dimmer evening light. Being exposed to bright, stable daytime light was linked to enhanced and more sustained attention in a visual search task in which participants were asked to find a specific target on a page. Higher daytime light exposure and fewer switches between light and dark were linked to improved cognitive performance. And higher daytime light exposure and earlier estimated bedtimes were also associated with stronger relationships between recent light exposure and subjective sleepiness. However, neither the time of day nor time awake significantly impacted cognitive performance; the effect of light was stronger than the effect of time of day.   Breastfeeding may lower mums' later life depression/anxiety risks for up to 10 years after pregnancy University College Dublin (Ireland), January 8 2026 (Eurekalert)   Breastfeeding may lower mothers' later life risks of depression and anxiety for up to 10 years after pregnancy, suggest the findings of a small observational study, published in the open access journal BMJ Open. The observed associations were apparent for any, exclusive, and cumulative (at least 12  months) breastfeeding, the study shows. The researchers tracked the breastfeeding behaviour and health of 168 second time mothers who were originally part of the ROLO Longitudinal Birth Cohort Study for 10 years.   At the check-ups, the mothers provided information on: whether they had ever breastfed or expressed milk for 1 day or more; total number of weeks of exclusive breastfeeding; total number of weeks of any breastfeeding; and cumulative periods of breastfeeding of less or more than 12 months.   The study concludes there may be a protective effect of successful breastfeeding on postpartum depression and anxiety, which in turn lowers the risk of maternal depression and anxiety in the longer term.

“I feel like I should be doing better by now.” In this episode, I unpack why that feeling is so common in PCOS — and why it's not a personal failure, but a gap in how PCOS care is delivered. Drawing from clinical experience and recent research, we explore three major blind spots in standard PCOS care:The high prevalence of disordered eating and eating disordersHow access, cost, stress, and food insecurity shape nutrition outcomesWhy many people are diagnosed without ever truly understanding their condition We'll break down what the research actually shows, connect it to real life, and explain why PCOS has never been a willpower problem — it's been a care-model problem. If you've been doing “everything right” and still feel stuck, this episode offers clarity, context, and a more human way forward! ✨ Learn more about our 1-on-1 nutrition care and PCOS Recovery Program If this episode resonated, leaving a rating or review helps others find inclusive, evidence-based PCOS support.  ReferencesBadri-Fariman M, Naeini AA, Mirzaei K, Moeini A, Hosseini M, Bagheri SE, Daneshi-Maskooni M. Association between the food security status and dietary patterns with polycystic ovary syndrome (PCOS) in overweight and obese Iranian women: a case-control study. J Ovarian Res. 2021 Oct 13;14(1):134. doi: 10.1186/s13048-021-00890-1. PMID: 34645502; PMCID: PMC8515721.Lalonde-Bester S, Malik M, Masoumi R, Ng K, Sidhu S, Ghosh M, Vine D. Prevalence and Etiology of Eating Disorders in Polycystic Ovary Syndrome: A Scoping Review. Adv Nutr. 2024 Apr;15(4):100193. doi: 10.1016/j.advnut.2024.100193. Epub 2024 Feb 24. PMID: 38408541; PMCID: PMC10973592.Liu Y, Guo Y, Yan X, Ding R, Tan H, Wang Y, Wang X, Wang L. Assessment of health literacy in patients with polycystic ovary syndrome and its relationship with health behaviours: a cross-sectional study. BMJ Open. 2023 Nov 24;13(11):e071051. doi: 10.1136/bmjopen-2022-071051. PMID: 38000817; PMCID: PMC10680007.PROOF. New data on household food insecurity in 2024. PROOF. Published May 5, 2025. https://proof.utoronto.ca/2025/new-data-on-household-food-insecurity-in-2024/

In the first Communicable episode of 2026, Annie Joseph and Josh Nosanchuk invite Robin Patel (Rochester, USA) and Fidelma Fitzpatrick (Dublin, Ireland) to discuss some of their favourite clinical microbiology papers published in 2025. These six papers highlight everything from technological advances of genomics and molecular diagnostic testing to the importance of patient and public involvement in research as well as effective communication [1-6]. The panel also discusses whether or not any of these papers have changed their practice.This episode was edited by Kathryn Hostettler and peer reviewed by Sinéad Kilgarriff of the National Virus Reference Laboratory University College, Dublin in Ireland. Robin's papersOyeniran SJ, et al. J Clin Microbiol 2025. DOI: https://doi.org/10.1128/jcm.00986-25 Xie O, et al. Lancet Microbe 2025. DOI: 10.1016/j.lanmic.2025.101182Lopopolo M et al., Science 2025. DOI: 10.1126/science.adu7144Fidelma's papersTurner NA, et al. JAMA 2025. DOI: 10.1001/jama.2025.12543  Paterson DL, et al. Lancet Infectious Diseases 2025. DOI: 10.1016/S1473-3099(25)00469-4Langford BJ, et al. Antimicrobial Stewardship & Healthcare Epidemiology 2025. DOI: 10.1017/ash.2025.10210Related podcast episodesCommunicable episode 1: Late breaker trials at ESCMID Global 2024, https://share.transistor.fm/s/9c598f68ReferencesOyeniran SJ, et al. J Clin Microbiol 2025. DOI: https://doi.org/10.1128/jcm.00986-25 Xie O, et al. Lancet Microbe 2025. DOI: 10.1016/j.lanmic.2025.101182Turner NA, et al. JAMA 2025. DOI: 10.1001/jama.2025.12543  Paterson DL, et al. Lancet Infectious Diseases 2025. DOI: 10.1016/S1473-3099(25)00469-4Lopopolo M et al., Science 2025. DOI: 10.1126/science.adu7144Langford BJ, et al. Antimicrobial Stewardship & Healthcare Epidemiology 2025. DOI: 10.1017/ash.2025.10210Further readingMohammed HT, et al. IJSEM 2025. DOI: 10.1099/ijsem.0.006986  Skally M, et al. BMJ Open 2025. DOI: 10.1136/bmjopen-2025-103431Ong SWX and Tverring J. CMI Communications 2025. DOI: 10.1016/j.cmicom.2025.105154Tverring J and Ong SWX. CMI Communications 2025. DOI: 10.1016/j.cmicom.2025.105169 

Special guest, Denisha Gingles, returns to the show to update our perceptions of good leadership with a decidedly non-Western traditional mindset of culturally responsive practices. For example, did you know that some cultures appreciate a greater sense of unity from their leaders? Apparently one giant know-it-all doesn't necessarily make for the best boss—looking at you, American CEOs! Learn how embracing a more diverse workforce can also benefit goals of meaningful mentorship and growth in our field with some examples from the medical world and how much we really should learn from rugby. This episode is available for 1.0 CULTURAL (ETHICS) CEU. Articles discussed this episode: Sriram, V., Atwal, A., & McKay, E.A. (2024). Exploring aspects of mentoring for black and minoritised healthcare professionals in the UK: A nominal group technique study. BMJ Open, 14. doi: 10.1136/bmjopen-2024-089121 Kemzang, J., Bekolo, G., Jaunky, S., Mathieu, J., Contant, H., Oguntala, J., Rahmani, M., Louisme, M.C., Medina, N., Kendall, C.E., Ewurabena, S., Hubert, D., Omecq, M.C., & Fotsing, S. (2024). Mentoring for admission and retention of black socio-ethnic minorities in medicine: A scoping review. Journal of Medical Education and Curricular Development, 11, 1-9. doi: 10.1177/23821205241283805 Shaikh, A.N., Gummaluri, S., Dhar, J., Carter, H., Kwag, D. (2024). Application of the principles of anti-oppression to address marginalized students and faculty's experiences in counselor education. Teaching and Supervision in Counseling, 6, 94-105. doi: 10.7290/tsc06laio Laloo, E. (2022). Ubuntu leadership - an explication of an Afrocentric leadership style. The Journal of Values-Based Leadership, 15, 1-9. doi: 10.22543/1948-0733.1383 Mathur, S.K. & Rodriguez, K.A. (2022). Cultural responsiveness curriculum for behavior analysts: A meaningful step toward social justice. Behavior Analysis in Practice, 15, 1023-1031. doi: 10.1007/s40617-021-00579-3 If you're interested in ordering CEs for listening to this episode, click here to go to the store page. You'll need to enter your name, BCBA #, and the two episode secret code words to complete the purchase. Email us at abainsidetrack@gmail.com for further assistance.

Chegou o episódio escolhido por vocês! Marcela Belleza e Joanne Alves convidam Carol Millon para conversar sobe 6 clinicagens de inibidores de SGLT2, as gliflozinas:Indicações além do DMRisco de CAD euglicêmicaQuando não usar?⁠Cuidados com doença aguda (sick day) e hipovolemia⁠Cuidados pré-operatórioRisco de fratura e amputaçãoReferências:1. Bailey CJ, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43. Published 2013 Feb 20. doi:10.1186/1741-7015-11-432. Bersoff-Matcha SJ, et al. Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med. 2019;170(11):764-769. doi:10.7326/M19-00853. Chang HY, et al. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes. JAMA Intern Med. 2018;178(9):1190-1198. doi:10.1001/jamainternmed.2018.3034 4. Clar C, et al. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open. 2012 Oct 18;2(5):e001007. doi: 10.1136/bmjopen-2012-001007. PMID: 23087012; PMCID: PMC3488745.5. Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5. PMID: 32771263; PMCID: PMC7545583. 6. Fralick M, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. Published 2020 Aug 25. doi:10.1136/bmj.m28127. Li D, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19(3):348-355. doi:10.1111/dom.128258. Neal B, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-223.e11. doi:10.1016/j.ahj.2013.05.0079. Nyirjesy P, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-1178. doi:10.1185/03007995.2012.69705310. Perkovic V, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. doi:10.1056/NEJMoa181174411. Rosenwasser RF, et al. SGLT-2 inhibitors and their potential in the treatment of diabetes. Diabetes Metab Syndr Obes. 2013 Nov 27;6:453-67. doi: 10.2147/DMSO.S34416. PMID: 24348059; PMCID: PMC3848644.12. Sridharan K, Sivaramakrishnan G. Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Opin Drug Saf. 2025;24(7):797-804. doi:10.1080/14740338.2024.237775513. Ueda P,  et al. Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study. BMJ. 2018;363:k4365. Published 2018 Nov 14. doi:10.1136/bmj.k436514. Watts NB, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 Jan;101(1):157-66. doi: 10.1210/jc.2015-3167. Epub 2015 Nov 18. PMID: 26580237; PMCID: PMC4701850.15. Zhuo M, et al. Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fracture Risk in Older Adults With Type 2 Diabetes. JAMA Netw Open. 2021;4(10):e2130762. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.3076216. Emerson Cestari Marino, Leandra Anália Freitas Negretto, Rogério Silicani Ribeiro, Denise Momesso, Alina Coutinho Rodrigues Feitosa, Marcos Tadashi Kakitani Toyoshima, Joaquim Custódio da Silva Junior, Sérgio Vencio, Marcio Weissheimer Lauria, João Roberto de Sá, Domingos A. Malerbi, Fernando Valente, Silmara A. O. Leite, Danillo Ewerton Oliveira Amaral, Gabriel Magalhães Nunes Guimarães, Plínio da Cunha Leal, Maristela Bueno Lopes, Luiz Carlos Bastos Salles, Liana Maria Torres de Araújo Azi, Amanda Gomes Fonseca, Lorena Ibiapina M. Carvalho, Francília Faloni Coelho, Bruno Halpern, Cynthia M. Valerio, Fabio R. Trujilho,  Antonio Carlos Aguiar Brandão, Ruy Lyra e Marcello Bertoluci. Rastreamento e Controle da Hiperglicemia no Perioperatório – Posicionamento Conjunto da Sociedade Brasileira de Diabetes (SBD), Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica (ABESO). Diretriz Oficial da Sociedade Brasileira de Diabetes (2025). DOI: 10.29327/5660187.2025-10 , ISBN: 978-65-5941-367-6.17. Singh LG, Ntelis S, Siddiqui T, Seliger SL, Sorkin JD, Spanakis EK. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2024;47(6):933-940. doi:10.2337/dc23-112918. Mehta PB, Robinson A, Burkhardt D, Rushakoff RJ. Inpatient Perioperative Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter-2 Inhibitors - Lessons From a Case Series and Strategies to Decrease Incidence. Endocr Pract. 2022;28(9):884-888. doi:10.1016/j.eprac.2022.06.00619. Umapathysivam MM, Morgan B, Inglis JM, et al. SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Netw Open. 2024;7(3):e242744. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.274420. Fleming N, Hamblin PS, Story D, Ekinci EI. Evolving Evidence of Diabetic Ketoacidosis in Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors. J Clin Endocrinol Metab. 2020;105(8):dgaa200. doi:10.1210/clinem/dgaa20021. Neuen BL, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2019;7(11):845-854. doi:10.1016/S2213-8587(19)30256-622. Braunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med. 2022;386(21):2024-2034. doi:10.1056/NEJMra211501123. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa150472024. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-657. doi:10.1056/NEJMoa161192525. Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380(4):347-357. doi:10.1056/NEJMoa181238926. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa191130327. Packer M, Anker SD, Butler J, et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413-1424. doi:10.1056/NEJMoa202219028. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa210703829. Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi:10.1056/NEJMoa202481630. The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, et al. Empagliflozin in...

Mel Haberfield and Brooke Patterson are leading sports physiotherapists with expertise at the intersection of elite performance and cutting-edge research. Mel has worked extensively in elite sport across basketball, gymnastics, and the AFL, and is currently completing a PhD focused on knee injuries in athletes. Her work bridges high-performance sport and evidence-based injury prevention and rehabilitation. Brooke is an Australian Research Council Early Career Industry Research Fellow whose research is shaping the future of knee injury and concussion prevention in women's Australian Football. Her PhD examined the long-term impact of ACL reconstruction on young adults, including early osteoarthritis, symptoms, and quality of life. A former elite Australian footballer and semi-professional basketball player, Brooke also brings firsthand experience as an elite-level coach, giving her a unique athlete-to-clinician perspective. In this episode of the How I Rehab podcast, Mel and Brooke share their initial motivation in dedicating their careers to improving female athlete health. As well as discussing: Gender bias in elite sport and actionable changes that are required to improve this moving forward. How clinicians can implement the Prep-to-Play program at a community and sub-elite level. What do women want when it comes to their knee health? What did the FAIR consensus tell us about modifiable risk factors for injury? Key considerations for female athlete rehabilitation post ACL Injury - the 7 key clusters. The TRAIL-W - Knee health, and associations with female-specific health, physical, psychological, and social-gendered factors in women runners.  https://youtu.be/uFnVsz_ezAg Additional References Injury prevention for women and girls playing Australian Football: programme cocreation, dissemination and early adopter coach feedback. What Do Women (With Serious Knee Injury) Want to Know About Knee Health? Identifying Research Priorities with a Consumer Advisory Group Considerations for a women's rehabilitation programme following anterior cruciate ligament reconstruction: a concept mapping approach to enhance women's outcomes. Modifiable risk factors for lower-extremity injury: a systematic review and meta-analysis for the Female, woman and/or girl Athlete Injury prevention (FAIR) consensus Patterson et al (2024). Injury prevention for women and girls playing Australian Football: programme cocreation, dissemination and early adopter coach feedback. Patterson et al (2022). Evaluation of an injury prevention programme (Prep-to-Play) in women and girls playing Australian Football: design of a pragmatic, type III, hybrid implementation-effectiveness, stepped-wedge, cluster RCT. BMJ Open, 12(9), e062483 Prep to Play program resources

Auch in Jahr sechs nach Beginn der Corona-Pandemie leiden Hunderttausende an Long Covid. Welche Erklärungen und Therapien gibt es mittlerweile? 1,5 Millionen Menschen in Deutschland leiden einer Schätzung der ME/CFS Foundation zufolge an schwerem Long Covid oder ME/CFS. Doch noch immer mangelt es an wirksamen Therapien - und an ausreichender Versorgung. Viele Betroffene pilgern von einer Praxis zur nächsten, die meisten müssen die Behandlungen aus eigener Tasche bezahlen. Denn das Krankheitsbild ist divers, es gibt mehr als 200 Symptome. Und es sind ganz verschiedene Mechanismen, die die Menschen so krank machen. Was weiß man heute? Wie entsteht Long Covid? Welche Wege führen zu einer besseren Versorgung? Und welche erfolgversprechenden Therapieansätze gibt es? Darüber spricht Wissenschaftsredakteurin Korinna Hennig in einer Live-Podcastfolge aus dem Haus der Wissenschaft in Braunschweig mit Experten. Mit dabei: Der Infektionsbiologe Dieter Jahn (TU Braunschweig) und die Hausärztin Susanne Fröhlich aus Isernhagen. HINTERGRUNDINFORMATIONEN: Studie zu Immunadsorption: Stein, E. et al.: Efficacy of repeated immunoadsorption in patients with post-COVID myalgic encephalomyelitis/chronic fatigue syndrome and elevated β2-adrenergic receptor autoantibodies: a prospective cohort study-The Lancet Regional Health Europe 2024. https://pubmed.ncbi.nlm.nih.gov/39759581/#:~:text=Interpretation%3A%20Immunoadsorption%20may%20improve%20symptoms,function%20in%20the%20condition%27s%20pathophysiology Studie zu hyperbarer Sauerstofftherapie: Kjellberg, A. et al.: Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial. BMJ Open 2025. https://pubmed.ncbi.nlm.nih.gov/40228859/ Studie zu HELP-Apherese/Blutwäsche: Espana-Cueto, Sergio et al: Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial. Nature Communications 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC11850642/ Links zu der Doppelfolge der "Science Cops" zu Long Covid: https://www.ardaudiothek.de/episode/urn:ard:episode:f2e192241785f729/ https://www.ardaudiothek.de/episode/urn:ard:episode:cee04aafe360636e/ Link zu "Deep Science" vom Deutschlandfunk: https://www.ardaudiothek.de/sendung/deep-science/urn:ard:show:498714386e4aad63/ Hier geht's zum Podcast ARD Klima Update: https://1.ard.de/ARD_Klima_Update?cp=synapsen Hier geht's zur Synapsenseite: https://www.ndr.de/nachrichten/podcastsynapsen100.html Hier geht's zu ARD Gesund: https://www.ndr.de/ratgeber/gesundheit Habt ihr Feedback oder einen Lifehack aus der Welt der Wissenschaft? Schreibt uns gerne an synapsen@ndr.de.

Auch in Jahr sechs nach Beginn der Corona-Pandemie leiden Hunderttausende an Long Covid. Welche Erklärungen und Therapien gibt es mittlerweile? 1,5 Millionen Menschen in Deutschland leiden einer Schätzung der ME/CFS Foundation zufolge an schwerem Long Covid oder ME/CFS. Doch noch immer mangelt es an wirksamen Therapien - und an ausreichender Versorgung. Viele Betroffene pilgern von einer Praxis zur nächsten, die meisten müssen die Behandlungen aus eigener Tasche bezahlen. Denn das Krankheitsbild ist divers, es gibt mehr als 200 Symptome. Und es sind ganz verschiedene Mechanismen, die die Menschen so krank machen. Was weiß man heute? Wie entsteht Long Covid? Welche Wege führen zu einer besseren Versorgung? Und welche erfolgversprechenden Therapieansätze gibt es? Darüber spricht Wissenschaftsredakteurin Korinna Hennig in einer Live-Podcastfolge aus dem Haus der Wissenschaft in Braunschweig mit Experten. Mit dabei: Der Infektionsbiologe Dieter Jahn (TU Braunschweig) und die Hausärztin Susanne Fröhlich aus Isernhagen. HINTERGRUNDINFORMATIONEN: Studie zu Immunadsorption: Stein, E. et al.: Efficacy of repeated immunoadsorption in patients with post-COVID myalgic encephalomyelitis/chronic fatigue syndrome and elevated β2-adrenergic receptor autoantibodies: a prospective cohort study-The Lancet Regional Health Europe 2024. https://pubmed.ncbi.nlm.nih.gov/39759581/#:~:text=Interpretation%3A%20Immunoadsorption%20may%20improve%20symptoms,function%20in%20the%20condition%27s%20pathophysiology Studie zu hyperbarer Sauerstofftherapie: Kjellberg, A. et al.: Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial. BMJ Open 2025. https://pubmed.ncbi.nlm.nih.gov/40228859/ Studie zu HELP-Apherese/Blutwäsche: Espana-Cueto, Sergio et al: Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial. Nature Communications 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC11850642/ Links zu der Doppelfolge der "Science Cops" zu Long Covid: https://www.ardaudiothek.de/episode/urn:ard:episode:f2e192241785f729/ https://www.ardaudiothek.de/episode/urn:ard:episode:cee04aafe360636e/ Link zu "Deep Science" vom Deutschlandfunk: https://www.ardaudiothek.de/sendung/deep-science/urn:ard:show:498714386e4aad63/ Hier geht's zum Podcast ARD Klima Update: https://1.ard.de/ARD_Klima_Update?cp=synapsen Hier geht's zur Synapsenseite: https://www.ndr.de/nachrichten/podcastsynapsen100.html Hier geht's zu ARD Gesund: https://www.ndr.de/ratgeber/gesundheit Habt ihr Feedback oder einen Lifehack aus der Welt der Wissenschaft? Schreibt uns gerne an synapsen@ndr.de.

Much like the amount of time the New England sun stays up, enjoy a short preview of what's coming out in the darkest days of December on the podcast. This month we've got three special guests including SLP, Judy Southey leading us through the new "How To" all about PECS; Denisha Gingles to lead us through a discussion of leadership practices in ABA, and Matt Cicoria leading us into the new year by reviewing what happened in ABA in 2025 in our yearly special episode. And, to round things out, a discussion about exactly what makes up assent practices. Yule love it all! Articles for December 2025 Tutorial: PECS with Judy Southey Robertson, M. & Harris, T. (2024, December 30th). How to best determine if an autistic individual is using an effective communication system. Autism Spectrum News. https://autismspectrumnews.org/how-to-best-determine-if-an-autistic-individual-is-using-an-effective-communication-system Wannapaschaiyong, P., Vivattanasinchai, T., & Wongkwanmuang, A. (2025). Predictors of successful Picture Exchange Communication System training in children with communication impairments: Insights from a real-world intervention in a resource-limited setting. BMJ Paediatrics Open, 9, 1-13. doi: 10.1136/bmjpo-2024-003282 Ganz, J.B., Mason, R.A., Goodwyn, F.D., Boles, M.B., Heath, A.K., & Davis, J.L. (2014). Interaction of participant characteristics and type of AAC with individuals with ASD: A meta-analysis. American Journal on Intellectual and Developmental Disabilities, 119, 516-535. doi: 10.1352/1944-7558-119.6.516   Culturally Reponsive Leadership Practices in ABA w/ Denisha Gingles Sriram, V., Atwal, A., & McKay, E.A. (2024). Exploring aspects of mentoring for black and minoritised healthcare professionals in the UK: A nominal group technique study. BMJ Open, 14. doi: 10.1136/bmjopen-2024-089121 Kemzang, J., Bekolo, G., Jaunky, S., Mathieu, J., Contant, H., Oguntala, J., Rahmani, M., Louisme, M.C., Medina, N., Kendall, C.E., Ewurabena, S., Hubert, D., Omecq, M.C., & Fotsing, S. (2024). Mentoring for admission and retention of black socio-ethnic minorities in medicine: A scoping review. Journal of Medical Education and Curricular Development, 11, 1-9. doi: 10.1177/23821205241283805 Shaikh, A.N., Gummaluri, S., Dhar, J., Carter, H., Kwag, D. (2024). Application of the principles of anti-oppression to address marginalized students and faculty's experiences in counselor education. Teaching and Supervision in Counseling, 6, 94-105. doi: 10.7290/tsc06laio Laloo, E. (2022). Ubuntu leadership - an explication of an Afrocentric leadership style. The Journal of Values-Based Leadership, 15, 1-9. doi: 10.22543/1948-0733.1383 Mathur, S.K. & Rodriguez, K.A. (2022). Cultural responsiveness curriculum for behavior analysts: A meaningful step toward social justice. Behavior Analysis in Practice, 15, 1023-1031. doi: 10.1007/s40617-021-00579-3   Operationalizing Assent Mead Jasperse, S.C., Kelly, M.P., Ward, S.N., Fernand, J.K., Joslyn, P.R., & van Dijk, W. (2025). Consent and assent practices in behavior analytic research. Behavior Analysis in Practice, 18, 826-841. doi: 10.1007/s40617-023-00838-5  Flowers, J. & Dawes, J. (2023). Dignity and respect: Why therapeutic assent matters. Behavior Analysis in Practice, 16, 913-920. doi: 10.1007/s40617-023-00772-6

Oui, plusieurs études scientifiques ont montré une corrélation entre les pics de pollen dans l'air et une hausse du nombre de suicides. Ce n'est pas une relation de cause à effet directe, mais plutôt un facteur aggravant qui pourrait influencer la santé mentale, surtout chez les personnes déjà fragiles psychologiquement.Une étude publiée en 2025 dans le Journal of Health Economics intitulée « Seasonal allergies and mental health: Do small health shocks affect suicidality? » a analysé plus de dix ans de données aux États-Unis, couvrant 34 zones métropolitaines entre 2006 et 2018. Les chercheurs ont constaté qu'au cours des journées où la concentration de pollen était la plus élevée, le nombre de suicides augmentait d'environ 7,4 % par rapport aux jours où le pollen était au plus bas. Cette hausse atteignait même 8,6 % chez les personnes ayant déjà un suivi pour troubles mentaux. Une autre recherche publiée dans la revue BMJ Open en 2013 en Europe allait dans le même sens, confirmant que les jours de forte pollinisation étaient associés à un risque plus élevé de suicide.Pourquoi cette association ? Plusieurs mécanismes biologiques et psychologiques peuvent l'expliquer. D'abord, les allergies au pollen déclenchent une réaction inflammatoire dans l'organisme : le système immunitaire libère des cytokines et de l'histamine, substances qui peuvent influencer la chimie du cerveau et modifier l'humeur. Certaines études en neurosciences suggèrent que l'inflammation chronique pourrait jouer un rôle dans la dépression. Ensuite, les symptômes physiques liés aux allergies — nez bouché, toux, fatigue, troubles du sommeil — altèrent la qualité de vie et peuvent accentuer l'irritabilité ou la lassitude. À cela s'ajoute un facteur psychologique : au printemps, période souvent associée à la vitalité et au renouveau, certaines personnes souffrant de dépression ressentent un contraste plus fort entre leur état intérieur et le monde extérieur, ce qui peut accentuer leur détresse.Il faut cependant rester prudent : le pollen ne “provoque” pas le suicide. C'est un facteur parmi d'autres qui peut fragiliser l'équilibre psychique, notamment chez les individus vulnérables. Les chercheurs parlent d'un “petit choc environnemental”, un élément supplémentaire qui peut, dans certaines circonstances, faire basculer quelqu'un déjà en difficulté.En résumé, les jours où le taux de pollen est très élevé coïncident souvent avec une légère hausse des suicides. Le phénomène s'expliquerait par les effets combinés de l'inflammation, du manque de sommeil et de la vulnérabilité émotionnelle. Une donnée que la recherche en santé mentale commence désormais à prendre au sérieux. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Dame Jilly Cooper died of an acute subdural haematoma, following a fall.   Pathways for CT head in adults exist to guide us in determining who needs a CT, but we must not forget the importance of safety netting all elderly people after head injury and to consider measures to prevent patients sustaining head injuries in the first place.   Check out the papers mentioned.   Evans LR, Jones J, Lee HQ, Gantner D, Jaison A, Matthew J, Fitzgerald MC, Rosenfeld JV, Hunn MK, Tee JW. Prognosis of Acute Subdural Hematoma in the Elderly: A Systematic Review. J Neurotrauma. 2019 Feb 15;36(4):517-522. doi: 10.1089/neu.2018.5829. Epub 2018 Aug 14. PMID: 29943683. Link Manivannan S, Spencer R, Marei O, Mayo I, Elalfy O, Martin J, Zaben M. Acute subdural haematoma in the elderly: to operate or not to operate? A systematic review and meta-analysis of outcomes following surgery. BMJ Open. 2021 Dec 3;11(12):e050786. doi: 10.1136/bmjopen-2021-050786. PMID: 34862284; PMCID: PMC8647543. Link  Kuhn EN, Erwood MS, Oster RA, Davis MC, Zeiger HE, Pittman BC, Fisher WS 3rd. Outcomes of Subdural Hematoma in the Elderly with a History of Minor or No Previous Trauma. World Neurosurg. 2018 Nov;119:e374-e382. doi: 10.1016/j.wneu.2018.07.168. Epub 2018 Jul 30. PMID: 30071339. Link MdCalc Canadian CT Head tool   BBC Article about Dame Jilly Cooper   www.rnzcuc.org.nz podcast@rnzcuc.org.nz https://www.facebook.com/rnzcuc https://twitter.com/rnzcuc   Music licensed from www.premiumbeat.com Full Grip by Score Squad   This podcast is intended to assist in ongoing medical education and peer discussion for qualified health professionals.  Please ensure you work within your scope of practice at all times.  For personal medical advice, always consult your usual doctor 

Un nouvel épisode du Pharmascope est disponible! Dans ce 89ème épisode, premier d'une série de deux concernant l'usage du fer, Nicolas, Sébastien et Isabelle animeront vos globules rouges en vous parlant de l'évaluation d'une carence en fer, des indications de traitement ainsi que des différences cliniques entre les différentes formulations de fer. Les objectifs pour cet épisode sont les suivants: Interpréter un résultat de ferritine Identifier les patients pouvant bénéficier d'un traitement de fer Comparer les avantages et inconvénients cliniques des différentes formulations de fer    Ressources pertinentes en lien avec l'épisode Lignes directrices Snook J et coll. British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. Gut. 2021;70:2030-51. British Columbia Ministry of Health. Iron Deficiency – Diagnosis and Management. BCGuidelines.ca. Avril 2019. Article de revue Pasricha S-R et coll. Iron deficiency. Lancet. 2021;397:233-48. Document de l'INESSS sur l'utilisation du bilan martial Boughrassa F, Framarin A. Usage judicieux de 14 analyses biomédicales. Institut national d'excellence en santé et en services sociaux. Avril 2014. Revues du traitement de la carence en fer sans anémie Miles LF et coll. Intravenous iron therapy for non anaemic, iron deficient adults. Cochrane Database Syst Rev. 2019;12:CD013084. Houston BL et coll. Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials. BMJ Open. 2018;8:e019240. McKennitt D, Allan GM. Iron Supplementation in Non-Anemic Women with Unexplainable Fatigue: Another Tired Theory? Tools for Practice 79. Août 2016. Revue de la comparaison de l'efficacité et l'innocuité de types de fer Moe S, Allan GM. New iron supplements for anemia. Can Fam Phys. 2019;65(8):556. Étude portant sur la prise concomitante de vitamine C Li N et coll. The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial. JAMA Network Open. 2020;3:e2023644.

Un nouvel épisode du pharmascope est maintenant disponible! Dans de ce 103ème épisode, Nicolas, Sébastien et Isabelle discutent encore une fois de vitamine B12. Cette fois, on jase de plein de choses: les médicaments pouvant causer une déficience en B12, la supplémentation en B12 et même de l'effet de la B12 sur les performances au karaoké!   Les objectifs pour cet épisode sont les suivants: Identifier les médicaments ou substances susceptibles de causer une déficience en vitamine B12 Comparer les avantages et les inconvénients des différentes voies d'administration disponibles pour l'administration de vitamine B12 Discuter du suivi à effectuer suite à l'amorce de la vitamine B12   Ressources pertinentes en lien avec l'épisode Boughrassa F, Framarin A. Usage judicieux de 14 analyses biomédicales: Outil pratique. Institut national d'excellence en santé et services sociaux. Avril 2014. Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349:g5226. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 2013;368:149-60. de Jager J et coll. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181. Sanz-Cuesta et coll; OB12 Group. Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non-inferiority clinical trial (OB12). BMJ Open. 2020;10:e033687. Wang H et coll. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018;3:CD004655. Volkov I et coll. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med. 2009;22:9-16.

Dr Ceri Battle is a Consultant Respiratory Physiotherapist and an Honorary Associate Professor in Swansea.  Ceri's PHD work led to the creation of the STUMBL score, a tool to help determine the risk of complications for patients with rib fractures.    Following her pre-recorded talk to our Bootcamp, she discusses the STUMBL score on the podcast and answers questions that arose from her talk last month.   Check out the STUMBL Score on MD Calc   Check out some of Ceri's work Battle C, Hutchings HA, Driscoll T, O'Neill C, Groves S, Watkins A, Lecky FE, Jones S, Gagg J, Body R, Abbott Z, Evans PA. A multicentre randomised feasibility STUdy evaluating the impact of a prognostic model for Management of BLunt chest wall trauma patients: STUMBL Trial. BMJ Open. 2019 Jul 26;9(7):e029187. doi: 10.1136/bmjopen-2019-029187. PMID: 31350248; PMCID: PMC6661629.  LINK Battle C, Cole E, Carter K, Baker E. Clinical prediction models for the management of blunt chest trauma in the emergency department: a systematic review. BMC Emerg Med. 2024 Oct 12;24(1):189. doi: 10.1186/s12873-024-01107-6. PMID: 39395934; PMCID: PMC11470733. LINK    www.rnzcuc.org.nz podcast@rnzcuc.org.nz https://www.facebook.com/rnzcuc https://twitter.com/rnzcuc   Music licensed from www.premiumbeat.com Full Grip by Score Squad   This podcast is intended to assist in ongoing medical education and peer discussion for qualified health professionals.  Please ensure you work within your scope of practice at all times.  For personal medical advice, always consult your usual doctor 

Join Dr. Brendan McCarthy, as he dives into Part 2 of our series on understanding the divide in modern medicine. In this episode, Dr. McCarthy explores: How education, corporate influence, and lobbying have shaped medicine and nutrition advice The history and impact of the food pyramid and dietary guidelines Why trust in traditional medicine has eroded and how alternative approaches gained popularity The role of pharmaceutical advertising and conference influence on medical practice Steps to rebuild trust and prioritize patient-centered care   Dr. McCarthy emphasizes accountability, understanding science objectively, and always keeping the patient's well-being at the center of care.  

Mit den kürzeren Tagen sinkt bei vielen Menschen nicht nur die Energie, sondern auch ihr Vitamin-D-Spiegel. Rutscht er zu sehr ab, hat das Folgen für Leistungsfähigkeit, Immunsystem und Stimmung.Eine neue Studie deutet darauf hin, dass Indoor-Training den im Winter üblichen Vitamin-D-Abfall messbar ausbremst. Kann Deine Fitness-Routine also das Vitamin-D-Supplement ersetzen? Am Ende der Folge bist Du auf Stand und weißt, was das für Dich und Deinen Vitamin-D-Haushalt bedeutet.Außerdem bekommst Du eine klare Strategie an die Hand, um die dunklen Monate von Oktober bis März energiegeladen (und mit vollen Vitamin-D-Speichern) zu überbrücken – statt im Wintermodus auf Reserve zu laufen.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Tools (Marks Empfehlungen):Vitamin-D-Selbsttest von Medivere.Vitamin-D-Präparat mit 2.000 IE von FormMed (vegane Variante).Weiterführende Inhalte:Download: Ratgeber NahrungsergänzungFolge 502: "Brauchen Sportler Nahrungsergänzung, Herr Ernährungsmediziner?" Mit Niels Schulz-RuhtenbergWissenschaftliche Literatur:Perkin OJ, Davies SE, Hewison M, et al. Exercise without weight loss prevents seasonal decline in vitamin D metabolites: The VitaDEx randomized controlled trial. Advanced Science. 2025;12(22):e2416312.Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology. 2014;21(3):319-329.Webb AR, Kazantzidis A, Kift RC, Farrar MD, Wilkinson J, Rhodes LE. Meeting vitamin D requirements in white Caucasians at UK latitudes: Providing a choice. Nutrients. 2018;10(4):497.Lin LY, Smeeth L, Langan S, Warren-Gash C. Distribution of vitamin D status in the UK: a cross-sectional analysis of UK Biobank. BMJ Open. 2021;11(1):e038503.de Oliveira LF, de Azevedo LG, da Mota Santana J, de Sales LPC, Pereira-Santos M. Obesity and overweight decreases the effect of vitamin D supplementation in adults: Systematic review and meta-analysis of randomized controlled trials. Reviews in Endocrine and Metabolic Disorders. 2020;21(1):67-76.Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690-693.Drincic AT, Armas LAG, Van Diest EE, Heaney RP. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012;20(7):1444-1448.Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One. 2014;9(11):e111265.Sun X, Cao ZB, Taniguchi H, Tanisawa K, Higuchi M. Effect of an acute bout of endurance exercise on serum 25(OH)D concentrations in young adults. Journal of Clinical Endocrinology & Metabolism. 2017;102(11):3937-3944.____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Die Themen in den Wissensnachrichten: +++ Wichtige Meeresströmung im Golf von Panama fast komplett ausgefallen +++ KI-Stethoskop kann bei Diagnose von Herzproblemen helfen +++ Spinne setzt Glühwürmchen als Köder ein +++**********Weiterführende Quellen zu dieser Folge:Unprecedented suppression of Panama's Pacific upwelling in 2025, PNAS, 02.09.2025Schwächere Passatwinde verhindern Tiefenwasserauftrieb im Golf von Panama, idw - Informationsdienst Wissenschaft, 02.09.202516 % der Studierenden brauchen eine Stunde oder länger für den Weg zur Hochschule, DESTATIS, 02.09.2025Humble stethoscope gets an upgrade: AI helps it detect three heart conditions in 15 seconds, Medical Xpress, 30.08.2025Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER): design and rationale for a decentralised, real-world cluster-randomised controlled trial and implementation study, BMJ Open, 21.05.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Drs. Whitney Hartlage (@whithartlage11) and Sam Windham join Dr. Ryan Moenster to discuss updates in the diagnosis and management of community-acquire pneumonia. Hear from our guests on the role of rapid diagnostic tests such as multiplex PCR and urinary antigen tests in the inpatient and outpatient setting, considerations for initiating steroids and withholding macrolides, and when to use short antibiotic durations. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. PMID: 38240492. Odeyemi Y, Tekin A, Schanz C, Schreier D, Cole K, Gajic O, Barreto E. Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193. Butler AM, Nickel KB, Olsen MA, Sahrmann JM, Colvin R, Neuner E, O'Neil CA, Fraser VJ, Durkin MJ. Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults. Clin Infect Dis. 2024 Oct 23:ciae519. doi: 10.1093/cid/ciae519. Epub ahead of print. PMID: 39442057; PMCID: PMC12355227. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. PMID: 36948555; PMCID: PMC10040075 Schober T, Wong K, DeLisle G, et al. Clinical outcomes of rapid respiratory virus testing in emergency departments. JAMA Intern Med. 2024;184(5):528-536. Clark T, Lindsley K, Wigmosta T, et al. Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: results of a systematic review and meta-analysis. J Infect. 2023;86(5):462-475. May L, Robbins EM, Canchola JA, Chugh K, Tran NK. A study to assess the impact of the cobas point-of-care RT-PCR assay (SARS-CoV-2 and Influenza A/B) on patient clinical management in the emergency department of the University of California at David Medical Center. J Clin Virol. 2023:168:105597. Cartuliares MB, Rosenvinge FS, Mogensen CB, Skovsted TA, Andersen SL, Østergaard C, et al. Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med. 2023;20:e1004314. doi: 10.1371/ journal.pmed.1004314. Vaughn VM, Dickson RP, Horowitz JK, Flanders SA. Community-acquired pneumonia: a review. JAMA. 2024;332(15):1282-1295. Davis MR, McCreary EK, Trzebucki AM. Things we do for no reason – ordering Streptococcus pneumoniae urinary antigen in patients with community-acquired pneumonia. Open Forum Infect Dis. 2024;11(3):ofae089. Centers for Disease Control and Prevention. Laboratory Testing for Legionella. Updated June 9, 2025. Accessed July 13, 2025. https://www.cdc.gov/legionella/php/laboratories/index.html. Jain S, Self WH, Wunderink RG. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415-427. Kamat IS, Ramachandram V, Eswaran H, Guffey D, Musher DM. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis. Clin Infect Dis. 2020;70(3):538-542. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single blinded intervention trial. Lancet. 2004;363:600–7. doi: 10.1016/S0140- 6736(04)15591-8. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059–66. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalci- € tonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Datab System Rev. 2017;10(10):CD007498. doi: 10.1002/14651858. cd007498.pub2. Huang DT, Yealy DM, Filbin MR, Brown AM, Chang C-CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower Respiratory tract infection. New Engl J Med. 2018;379:236–49. doi: 10.1056/NEJMoa1802670. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;389(19):1623-1634. doi:10.1056/NEJMoa2215145. Gupta AB, Flanders SA, Petty LA, et al. Inappropriate diagnosis of pneumonia among hospitalized adults. JAMA Intern Med. 2024;184(5):548-556. Jones BE, Chapman AB, Ying J, et al. Diagnostic Discordance, Uncertainty, and Treatment Ambiguity in Community-Acquired Pneumonia: A National Cohort Study of 115 U.S. Veterans Affairs Hospitals. Ann Intern Med. 2024;177(9):1179-1189. doi:10.7326/M23-2505. Hartlage W, Imlay H, Spivak ES. The role of empiric atypical antibiotic coverage in non-severe community-acquired pneumonia. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e214. doi:10.1017/ash.2024.453. Dinh A, Barbier F, Bedos JP, et al. Update of guidelines for management of community acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF). Endorsed by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF); endorsed by the French Intensive Care Society (SRLF), the French Microbiology Society (SFM), the French Radiology Society (SFR), and the French Emergency Society (SFMU). Respir Med and Res. 2025. El Moussaoui R, de Borgie CAJM, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ. 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355. Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia: a randomized, non-inferiority trial. Lancet. 2021;397(10280):1195-1203.

ENCORE: This episode was first published in Sept. 2023.In 1998, a young Norwegian exercise physiologist found that a technique he had used to help Olympic athletes could help heart patients too. But his idea made doctors sweat. One famous cardiologist told him that if he used his technique in human heart attack patients, he "would kill them."Today's show looks at what happened when our researcher, Ulrik Wisløff, defied the experts — and built a career learning how high intensity interval training can help everyone from heart patients and ageing Baby Boomers, and possibly even Alzheimer's patients — but not in the way you might think!Today's guests are Ulrik Wisløff, Dorthe Stensvold and Atefe Tari.Here's a link to a rat on a treadmill photo. And here's a link to a transcript.Here's a list of some of the research mentioned in the podcast:Wisløff U, et al. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.Wisløff U,et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. doi: 10.1161/CIRCULATIONAHA.106.675041. Epub 2007 Jun 4.Rognmo, Ø et al.. Cardiovascular Risk of High- Versus Moderate-Intensity Aerobic Exercise in Coronary Heart Disease Patients Circulation. 2012;126:1436-1440. doi: 10.1161/CIRCULATIONAHA.112.123117Stensvold D, Viken H, Steinshamn S L, Dalen H, Støylen A, Loennechen J P et al. Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 :m3485 Tari AR, Nauman J, Zisko N, Skjellegrind HK, Bosnes I, Bergh S, Stensvold D, Selbæk G, Wisløff U. Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study. Lancet Public Health. 2019 Nov;4(11):e565-e574.Tari AR, Berg HH, Videm V, Bråthen G, White LR, Røsbjørgen RN, Scheffler K, Dalen H, Holte E, Haberg AK, Selbaek G, Lydersen S, Duezel E, Bergh S, Logan-Halvorsrud KR, Sando SB, Wisløff U. Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study. BMJ Open. 2022 Sep 6;12(9):e056964. Hosted on Acast. See acast.com/privacy for more information.

In unserer heutigen Leistungsgesellschaft scheint kaum noch Platz zu sein für etwas so Fundamentales wie bewusstes Essen. Alles muss schnell gehen: Ein Happen im Auto, ein Snack im Gehen, ein To-Go-Salat am Schreibtisch. Hauptsache schnell. Hauptsache funktional. Doch genau darin liegt eine der größten Fallen unserer Zeit – das sogenannte To-Go-Essen. In dieser Folge spreche ich mit dir über ein Thema, das für viele zur Alltagsroutine geworden ist und dabei oft unterschätzt wird. Denn selbst wenn du vermeintlich gesund isst, leidet dein Körper, wenn du es nicht achtsam tust. Was viele nicht wissen: Die Verdauung beginnt nicht im Magen - sie beginnt im Kopf. Schon der Anblick und der Geruch von Nahrung bereiten den Körper darauf vor, Verdauungsenzyme zu aktivieren. Stress, Hektik und Ablenkung verhindern jedoch genau diesen natürlichen Prozess. Der Parasympathikus, unser sogenannter „Ruhenerv“, der für Regeneration und Verdauung zuständig ist, wird in Stresssituationen heruntergefahren - Nährstoffe können so kaum aufgenommen werden. Der Medizinischer Hintergrund: Studien zeigen, dass Stress und schnelles Essen mit einem erhöhten Risiko für Verdauungsprobleme, Entzündungen und langfristig sogar Übergewicht und Insulinresistenz einhergehen (u.a. Harvard Health Publishing, 2020; Journal of Nutrition, 2015). Wer regelmäßig unter Zeitdruck isst, hat laut einer Studie aus dem BMJ Open ein deutlich höheres Risiko für metabolisches Syndrom - ein gefährlicher Mix aus Bluthochdruck, Fettstoffwechselstörung und Bauchfett. Das Problem ist also nicht nur was wir essen, sondern wie. Du kannst noch so clean, nährstoffreich und bio essen - wenn du deinem Körper keine Zeit gibst, wirst du die Nährstoffe nicht aufnehmen können. In dieser Folge erfährst du: • Warum To-Go-Essen deinem Körper mehr schadet als nützt • Wie Stress deine Verdauung blockiert • Warum bewusstes Essen deine Gesundheit langfristig verbessern kann • Welche einfachen Strategien du ab morgen umsetzen kannst KOSTENFREIES WEBINAR AM 14.07.2025 | 19:00 UHR „Zeig mir, wie du isst und ich zeig dir, wie du wirklich tickst!“ Raus aus der To-Go-Falle: Zurück zu echter Ernährung! Wenn du dein Essverhalten langfristig verändern willst und echte, funktionierende Lösungen suchst, dann ist dieses Webinar genau das Richtige für dich. Wir schauen uns gemeinsam an, warum dein Körper so reagiert, wie er reagiert und was du konkret tun kannst, um wieder in die Kraft zu kommen. Mit dabei: • Wissenschaftlich fundierte Inhalte • Direkt umsetzbare Tipps für deinen Alltag • LIVE Q&A für all deine persönlichen Fragen Melde dich jetzt kostenfrei an und mach den ersten Schritt raus aus der Ernährungsfalle! https://andreas-trienbacher.com/webinar/  Aufwachen. Umdenken. Umsetzen. Es ist Zeit, Verantwortung zu übernehmen - für deinen Körper, deinen Geist und deine Gesundheit. Denn echte Veränderung beginnt genau hier.

In this episode of the Eat to Live podcast, Jenna joins Dr. Fuhrman to uncover the root causes of osteoporosis—and what really works to prevent and reverse it. They discuss why medications often fall short and how a Nutritarian diet, rich in greens, beans, plant protein, nuts, and seeds, can protect bone strength as we age. Dr. Fuhrman also breaks down the science behind targeted exercises—like those using a power plate machine—to rebuild bone density. Plus, special guest Isabel (Dr. Fuhrman's 97-year-old mother) shares how she transformed her health through a Nutritarian lifestyle and remains active, sharp, and independent well into her 90s. References: Nguyen ND, Ahlborg HG, Center JR, et al. Residual lifetime risk of fractures in women and men. J Bone Miner Res 2007, 22:781-788. Losina E, Weinstein AM, Reichmann WM, et al. Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US. Arthritis Care Res (Hoboken) 2013, 65:703-711. Lu B, Ahmad O, Zhang FF, et al. Soft drink intake and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative. BMJ Open 2013, 3. McAlindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996, 39:648-656.

Gambling Disorder (Gambling Addiction or Problem Gambling) explained, a very under-recognised condition. Includes the 9 core symptoms and diagnostic criteria, as well as treatment options. Consider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Gambling Disorder?0:38 Gambling Disorder Symptoms1:40 Gambling Disorder Diagnostic Criteria2:16 Gambling Disorder Risk Factors3:12 Gambling Disorder TreatmentReferencesAmerican Psychiatric Association Hector Colon-Rivera, M.D., CMRO, Kavita Fischer M.D., DFAPA (2024) - “What is Gambling Disorder?”. Available at https://www.psychiatry.org/patients-families/gambling-disorder/what-is-gambling-disorderMenchon JM, Mestre-Bach G, Steward T, Fernández-Aranda F, Jiménez-Murcia S. An overview of gambling disorder: from treatment approaches to risk factors. F1000Res. 2018 Apr 9;7:434. doi: 10.12688/f1000research.12784.1. PMID: 30090625; PMCID: PMC5893944. Available at https://pmc.ncbi.nlm.nih.gov/articles/PMC5893944/World Health Organisation (2024) - “Gambling”. Available at https://www.who.int/news-room/fact-sheets/detail/gamblingThomas SA, Merkouris SS, Browning CJ, Radermacher H, Feldman S, Enticott J, Jackson AC. The PROblem Gambling RESearch Study (PROGRESS) research protocol: a pragmatic randomised controlled trial of psychological interventions for problem gambling. BMJ Open. 2015 Nov 24;5(11):e009385. doi: 10.1136/bmjopen-2015-009385. PMID: 26603250; PMCID: PMC4663416. Available at https://pmc.ncbi.nlm.nih.gov/articles/PMC4663416/Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. 

Last episode we described the literature showing no survival benefit to patients with the AutoPulse device. Fear not, I wasn't ignoring the LUCAS, I just felt it deserved it's own episode. We'll cover the LINC and PARAMEDIC randomized controlled trials and the secondary analysis of LINC in shockable rhythms. I switched to a new production process using a new mic (Rode NT1) and started using ecamm to record. Yes, I know there is a bit of AV dysynchrony.. I'm working on it. I still have a lot to learn about ecamm but am optimistic about it. Citations on LUCAS device:1. Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, et al.: Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The LINC Randomized Trial. JAMA. 2014;January 1;311(1):53–61.2. Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther A-M, Woollard M, Carson A, et al.: Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. The Lancet. 2015;385(9972):947–55.3. Hardig BM, Lindgren E, Östlund O, Herlitz J, Karlsten R, Rubertsson S: Outcome among VF/VT patients in the LINC (LUCAS IN cardiac arrest) trial—A randomised, controlled trial. Resuscitation. 2017;June;115:155–62. Citations on Jeff's Tamiflu Rant1. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ: Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348:g2545.2. Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Onakpoya I, Heneghan CJ: Risk of bias in industry-funded oseltamivir trials: comparison of core reports versus full clinical study reports. BMJ Open. 2014;4(9):e005253.3. Jefferson T: The Tamiflu Story: Why We Need Access To All Data From Clinical Trials. Open Knowledge Foundation Blog. FAST25 | May 19-21, 2025 | Lexington, KY

En este podcast te quiero explicar el paso número uno que transformó mi relación con el móvil y cómo este simple cambio mejoró mi calidad de vida, productividad y sueño. También te explico por qué evitar el uso del móvil en las mañanas es clave para empezar tu día con enfoque y energía positiva.Descubre cómo implementé una rutina que eliminó mi adicción al móvil, los hábitos que fortalecen mi foco cognitivo y cómo puedes aplicar estos cambios en tu vida diaria. Si estás listo para recuperar el control sobre tu tiempo, este video es para ti.#adiccionalmovil #productividad #rutinamatutina #saludmental #calidaddelsueño #biohacking #gestiondeltiempo #PhilHugo #desarrollopersonal #hábitossaludablesEstudios:- Hysing, M., Pallesen, S., Stormark, K. M., Jakobsen, R., Lundervold, A. J., & Sivertsen, B. (2015). Sleep and use of electronic devices in adolescence: Results from a large population-based study. BMJ Open, 5(1), e006748. https://doi.org/10.1136/bmjopen-2014-006748- Ohayon, M. M., & Sagales, T. (2010). Prevalence of insomnia and sleep characteristics in the general population of Spain. Sleep Medicine, 11(10), 1010-1018. https://doi.org/10.1016/j.sleep.2010.02.018- Ohayon, M. M., & Bader, G. (2010). Prevalence and correlates of insomnia in the Swedish population aged 19-75 years. Sleep Medicine, 11(10), 980-986. https://doi.org/10.1016/j.sleep.2010.07.012

Drs. Nico Cortes-Penfield (@Cortes-Penfield), Kerry LaPlante (@Kerry_LaPlante), Jessica Seidelman (@JessieLSeidel) join Dr. Julie Ann Justo (@julie_justo) to discuss the pesky slime that is biofilm in periprosthetic joint infections. They review biofilm composition & development, have an honest discussion about whether antibiotics can ever really eradicate it, and provide updates on the promising non-pharmacologic strategies on the horizon (bacteriophages, electromagnetism, & more). Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp References Nixing the Nidus: Managing Retained Sources in Prosthetic Joint Infections. Breakpoints Podcast Episode #67. Society of Infectious Diseases Pharmacists. Dosing Consult: Rifampin Part 1. Breakpoints Podcast Episode #104. Society of Infectious Diseases Pharmacists. Review on Staphylococcal biofilm development: Schilcher K, Horswill AR. 2020 Aug 12;84(3):e00026-19. doi: 10.1128/MMBR.00026-19. PMID: 32792334. Antibiotics can fail to kill biofilm cells even if they penetrate the biofilm: Singh R, et al. Pathog Dis. 2016 Aug;74(6):ftw056. doi: 10.1093/femspd/ftw056. Epub 2016 Jul 7. PMID: 27402781. Subinhibitory antibiotic concentrations can promote biofilm formation: Schilcher K, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5957-67. doi: 10.1128/AAC.00463-16. PMID: 27458233. Clinical and genetic risk factors for biofilm-forming Staphylococcus aureus: Luther MK, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02252-17. doi: 10.1128/AAC.02252-17. PMID: 29530854. Meta-analysis showing poor clinical outcomes with debridement, antibiotics, and implant retention (DAIR): Kunutsor SK, et al. J Infect. 2018 Dec;77(6):479-488. doi: 10.1016/j.jinf.2018.08.017. PMID: 30205122. Thieme L, et al. MBEC versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology. Biol Proced Online 21, 18 (2019). https://doi.org/10.1186/s12575-019-0106-0. Ongoing trial investigating use of MBEC in the treatment of PJIs: Tillander JAN, et al. BMJ Open. 2022 Sep 15;12(9):e058168. doi: 10.1136/bmjopen-2021-058168. PMID: 36109038. Maale, G. Complete eradication of biofilm using low frequency electromagnetic force (EMF) and antibiotics at MIC. 34th Annual Meeting Musculoskeletal Infection Society. 2024 Aug. Abstract 1232 (see full program). Meta-analysis on bacteriophages for biofilm: Kovacs CJ, et al. Mil Med. 2024 May 18;189(5-6):e1294-e1302. doi: 10.1093/milmed/usad385. PMID: 37847552. Berking BB, et al. Biofilm disruption from within: light-activated molecular drill-functionalized polymersomes bridge the gap between membrane damage and quorum sensing-mediated cell death. ACS Biomater Sci Eng. 2024 Sep 9;10(9):5881-5891. doi: 10.1021/acsbiomaterials.4c01177. PMID: 39176452. Aboelnaga N, et al. Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances. Cell Commun Signal. 2024 Mar 22;22(1):188. doi: 10.1186/s12964-024-01511-2. PMID: 38519959. Conway J, et al. Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0065524. doi: 10.1128/aac.00655-24. PMID: 39012102. Mulpur P, et al. Efficacy of intrawound vancomycin in prevention of periprosthetic joint infection after primary total knee arthroplasty: a prospective double-blinded randomized control trial. J Arthroplasty. 2024 Jun;39(6):1569-1576. doi: 10.1016/j.arth.2024.01.003. PMID: 38749600. Dong Y, et al. Synergy of ultrasound microbubbles and vancomycin against Staphylococcus epidermidis biofilm. J Antimicrob Chemother. 2013 Apr;68(4):816-26. doi: 10.1093/jac/dks490. PMID: 23248238. Miltenberg B, et al. Intraosseous Regional Administration of Antibiotic Prophylaxis for Total Knee Arthroplasty: A Systematic Review. J Arthroplasty. 2023 Apr;38(4):769-774. doi: 10.1016/j.arth.2022.10.023. PMID: 36280158. Viswanathan VK, et al. Intraosseous regional antibiotic prophylaxis in total joint arthroplasty (TJA): Systematic review and meta-analysis. J Clin Orthop Trauma. 2024 Oct 3;57:102553. doi: 10.1016/j.jcot.2024.102553. PMID: 39435324. SOLARIO trial: Dudareva M, et al. The European Bone and Joint Infection Society Meeting, 2024 Sept. SOLARIO trial press release from BoneSupportTM. 2024 Oct 3. Fehring TK, et al. Does treatment at a specialized prosthetic joint infection center improve the rate of reimplantation. J Arthroplasty. 2023 Jun;38(6S):S314-7. PMID 37004968. ROADMAP trial website. 2024.

Egal zu welchem Anlass, in Deutschland wird gerne getrunken. Obwohl der Konsum seit Jahren langsam sinkt, liegen wir im internationalen Vergleich immer noch weit vorn. Schätzungen gehen davon aus, dass jährlich mehr als 40.000 Menschen in Deutschland an den Folgen ihres Alkoholkonsums vorzeitig sterben. Und dennoch gilt Alkoholtrinken immer noch als normal. Warum können - oder wollen - wir nicht auf diese Droge verzichten? Es nur mit dem Rausch, mit der kleinen Flucht aus dem Alltag zu erklären, wäre zu einfach.  Autorin Yasmin Appelhans ist dem Alkoholkonsum wissenschaftlich auf den Grund gegangen und hat dafür auch in der Evolutionsgeschichte gewühlt. Im Gespräch mit Host Lucie Kluth erzählt sie von ihren spannenden Erkenntnissen - unter anderem, warum unser Körper Alkohol relativ gut verarbeiten kann, was die forschungsrelevante "Drunken Monkey Hypothesis" damit zu tun hat und warum gerade Soziale Medien mitverantwortlich dafür sind, dass viele junge Menschen ihren Alkoholkonsum hinterfragen. DIE HINTERGRUNDINFORMATIONEN 1. Dudley R. Evolutionary Origins of Human Alcoholism in Primate Frugivory. The Quarterly Review of Biology. 2000;75(1): 3–15. https://doi.org/10.1086/393255. 2. Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, et al. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences. 2015;112(2): 458–463. https://doi.org/10.1073/pnas.1404167111. 3. Bowland AC, Melin AD, Hosken DJ, Hockings KJ, Carrigan MA. The evolutionary ecology of ethanol. Trends in Ecology & Evolution. 2024;0(0). https://doi.org/10.1016/j.tree.2024.09.005. 4. Dudley R, Maro A. Human Evolution and Dietary Ethanol. Nutrients. 2021;13(7): 2419. https://doi.org/10.3390/nu13072419. 5. Dashko S, Zhou N, Compagno C, Piškur J. Why, when, and how did yeast evolve alcoholic fermentation? Fems Yeast Research. 2014;14(6): 826–832. https://doi.org/10.1111/1567-1364.12161. 6. Milan NF, Kacsoh BZ, Schlenke TA. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology. 2012;22(6): 488–493. https://doi.org/10.1016/j.cub.2012.01.045. 7. Heinz A, Daedelow LS. Alkohol als Kulturgut – eine historisch-anthropologische und therapeutische Perspektive auf Alkoholkonsum und seine soziale Rolle in westlichen Gesellschaften. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2021;64(6): 646–651. https://doi.org/10.1007/s00103-021-03327-8. 8. Cooke R. The Palgrave handbook of psychological perspectives on alcohol consumption. Cham, Switzerland: Springer; 2021. 9. Alkoholkonsum in Deutschland: https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/a/alkohol.html [Accessed 9th December 2024]. 10. Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. The Lancet. 2010;376(9752): 1558–1565. https://doi.org/10.1016/S0140-6736(10)61462-6. 11. Mamluk L, Edwards HB, Savović J, Leach V, Jones T, Moore THM, et al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe' levels of alcohol during pregnancy? A systematic review and meta-analyses. BMJ Open. 2017;7(7): e015410. https://doi.org/10.1136/bmjopen-2016-015410. 12. Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. The Lancet. 2019;393(10190): 2493–2502. https://doi.org/10.1016/S0140-6736(18)32744-2. 13. Kilian C, Manthey J, Rehm J, Kraus L. Alkoholpolitik in Deutschland: Verpasste Chancen zur Senkung der Krankheitslast. SUCHT. 2023;69(4): 163–171. https://doi.org/10.1024/0939-5911/a000823. 14. Binder A, Kilian C, Hanke S, Banabak M, Berkenhoff C, Petersen KU, et al. Stigma and self-stigma among women within the context of the german “zero alcohol during pregnancy” recommendation: A qualitative analysis of online forums and blogs. International Journal of Drug Policy. 2024;124: 104331. https://doi.org/10.1016/j.drugpo.2024.104331. 15. Stockwell T, Zhao J, Clay J, Levesque C, Sanger N, Sherk A, et al. Why Do Only Some Cohort Studies Find Health Benefits From Low-Volume Alcohol Use? A Systematic Review and Meta-Analysis of Study Characteristics That May Bias Mortality Risk Estimates. Journal of Studies on Alcohol and Drugs. 2024;85(4): 441–452. https://doi.org/10.15288/jsad.23-00283. 16. Cook M, Critchlow N, O'Donnell R, MacLean S. Alcohol's contribution to climate change and other environmental degradation: a call for research. Health Promotion International. 2024;39(1): daae004. https://doi.org/10.1093/heapro/daae004. 17. 3.7 Genetik der Alkoholabhängigkeit.. 2011th ed. Alkohol und Tabak. Thieme Verlag; 2011. https://doi.org/10.1055/b-0034-40723. [Accessed 21st December 2024]. 18. Hakulinen C, Elovainio M, Batty GD, Virtanen M, Kivimäki M, Jokela M. Personality and Alcohol Consumption: Pooled Analysis of 72,949 Adults from Eight Cohort Studies. Drug and alcohol dependence. 2015;151: 110–114. https://doi.org/10.1016/j.drugalcdep.2015.03.008. 19. Heinz A, Gül Halil M, Gutwinski S, Beck A, Liu S. ICD-11: Änderungen der diagnostischen Kriterien der Substanzabhängigkeit. Der Nervenarzt. 2022;93(1): 51–58. https://doi.org/10.1007/s00115-021-01071-7. 20. Alkoholberatung: Alkohol? Kenn dein Limit. https://www.kenn-dein-limit.de/alkoholberatung/ [Accessed 21st December 2024].

Egal zu welchem Anlass, in Deutschland wird gerne getrunken. Obwohl der Konsum seit Jahren langsam sinkt, liegen wir im internationalen Vergleich immer noch weit vorn. Schätzungen gehen davon aus, dass jährlich mehr als 40.000 Menschen in Deutschland an den Folgen ihres Alkoholkonsums vorzeitig sterben. Und dennoch gilt Alkoholtrinken immer noch als normal. Warum können - oder wollen - wir nicht auf diese Droge verzichten? Es nur mit dem Rausch, mit der kleinen Flucht aus dem Alltag zu erklären, wäre zu einfach.  Autorin Yasmin Appelhans ist dem Alkoholkonsum wissenschaftlich auf den Grund gegangen und hat dafür auch in der Evolutionsgeschichte gewühlt. Im Gespräch mit Host Lucie Kluth erzählt sie von ihren spannenden Erkenntnissen - unter anderem, warum unser Körper Alkohol relativ gut verarbeiten kann, was die forschungsrelevante "Drunken Monkey Hypothesis" damit zu tun hat und warum gerade Soziale Medien mitverantwortlich dafür sind, dass viele junge Menschen ihren Alkoholkonsum hinterfragen. DIE HINTERGRUNDINFORMATIONEN 1. Dudley R. Evolutionary Origins of Human Alcoholism in Primate Frugivory. The Quarterly Review of Biology. 2000;75(1): 3–15. https://doi.org/10.1086/393255. 2. Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, et al. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences. 2015;112(2): 458–463. https://doi.org/10.1073/pnas.1404167111. 3. Bowland AC, Melin AD, Hosken DJ, Hockings KJ, Carrigan MA. The evolutionary ecology of ethanol. Trends in Ecology & Evolution. 2024;0(0). https://doi.org/10.1016/j.tree.2024.09.005. 4. Dudley R, Maro A. Human Evolution and Dietary Ethanol. Nutrients. 2021;13(7): 2419. https://doi.org/10.3390/nu13072419. 5. Dashko S, Zhou N, Compagno C, Piškur J. Why, when, and how did yeast evolve alcoholic fermentation? Fems Yeast Research. 2014;14(6): 826–832. https://doi.org/10.1111/1567-1364.12161. 6. Milan NF, Kacsoh BZ, Schlenke TA. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology. 2012;22(6): 488–493. https://doi.org/10.1016/j.cub.2012.01.045. 7. Heinz A, Daedelow LS. Alkohol als Kulturgut – eine historisch-anthropologische und therapeutische Perspektive auf Alkoholkonsum und seine soziale Rolle in westlichen Gesellschaften. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2021;64(6): 646–651. https://doi.org/10.1007/s00103-021-03327-8. 8. Cooke R. The Palgrave handbook of psychological perspectives on alcohol consumption. Cham, Switzerland: Springer; 2021. 9. Alkoholkonsum in Deutschland: https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/a/alkohol.html [Accessed 9th December 2024]. 10. Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. The Lancet. 2010;376(9752): 1558–1565. https://doi.org/10.1016/S0140-6736(10)61462-6. 11. Mamluk L, Edwards HB, Savović J, Leach V, Jones T, Moore THM, et al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe' levels of alcohol during pregnancy? A systematic review and meta-analyses. BMJ Open. 2017;7(7): e015410. https://doi.org/10.1136/bmjopen-2016-015410. 12. Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. The Lancet. 2019;393(10190): 2493–2502. https://doi.org/10.1016/S0140-6736(18)32744-2. 13. Kilian C, Manthey J, Rehm J, Kraus L. Alkoholpolitik in Deutschland: Verpasste Chancen zur Senkung der Krankheitslast. SUCHT. 2023;69(4): 163–171. https://doi.org/10.1024/0939-5911/a000823. 14. Binder A, Kilian C, Hanke S, Banabak M, Berkenhoff C, Petersen KU, et al. Stigma and self-stigma among women within the context of the german “zero alcohol during pregnancy” recommendation: A qualitative analysis of online forums and blogs. International Journal of Drug Policy. 2024;124: 104331. https://doi.org/10.1016/j.drugpo.2024.104331. 15. Stockwell T, Zhao J, Clay J, Levesque C, Sanger N, Sherk A, et al. Why Do Only Some Cohort Studies Find Health Benefits From Low-Volume Alcohol Use? A Systematic Review and Meta-Analysis of Study Characteristics That May Bias Mortality Risk Estimates. Journal of Studies on Alcohol and Drugs. 2024;85(4): 441–452. https://doi.org/10.15288/jsad.23-00283. 16. Cook M, Critchlow N, O'Donnell R, MacLean S. Alcohol's contribution to climate change and other environmental degradation: a call for research. Health Promotion International. 2024;39(1): daae004. https://doi.org/10.1093/heapro/daae004. 17. 3.7 Genetik der Alkoholabhängigkeit.. 2011th ed. Alkohol und Tabak. Thieme Verlag; 2011. https://doi.org/10.1055/b-0034-40723. [Accessed 21st December 2024]. 18. Hakulinen C, Elovainio M, Batty GD, Virtanen M, Kivimäki M, Jokela M. Personality and Alcohol Consumption: Pooled Analysis of 72,949 Adults from Eight Cohort Studies. Drug and alcohol dependence. 2015;151: 110–114. https://doi.org/10.1016/j.drugalcdep.2015.03.008. 19. Heinz A, Gül Halil M, Gutwinski S, Beck A, Liu S. ICD-11: Änderungen der diagnostischen Kriterien der Substanzabhängigkeit. Der Nervenarzt. 2022;93(1): 51–58. https://doi.org/10.1007/s00115-021-01071-7. 20. Alkoholberatung: Alkohol? Kenn dein Limit. https://www.kenn-dein-limit.de/alkoholberatung/ [Accessed 21st December 2024].

In this episode of Brown Women Health, we dive into two fascinating papers that highlight critical health issues for South Asian women and infants. First, we discuss the Nurture Early for Optimal Nutrition (NEON) pilot study, which explores the impact of participatory learning and action women's groups on improving infant feeding practices in South Asia. Next, we explore a qualitative synthesis of South Asian women's perspectives on maternity care services, shedding light on their unique experiences and challenges in accessing care. Join us as we break down these insightful studies and discuss their implications for improving maternal and infant health outcomes in South Asian communities. Papers Discussed: Nurture Early for Optimal Nutrition (NEON) Participatory Learning and Action Women's Groups to Improve Infant Feeding and Practices in South Asian Infants: Pilot Randomised Trial Study ProtocolManikam L, Allaham S, Patil P, et al. BMJ Open 2023;13:e063885.Read the paper here Exploring South Asian Women's Perspectives and Experiences of Maternity Care Services: A Qualitative Evidence SynthesisNagesh N, Ip CHL, Li J, et al. Women Birth 2024;37(2):259-277.Read the paper here Special Offer: This episode is brought to you by Magic Mind! If you're looking to improve focus and reduce stress, try Magic Mind and use our code BWHPOD20 for up to 48% off a subscription or 20% off a one-time purchase at magicmind.com/bwhpod --- Support this podcast: https://podcasters.spotify.com/pod/show/brownwomenhealth/support

In today's episode, I will address an important issue impacting workplaces worldwide: workplace depression. This topic affects everyone directly or indirectly through colleagues, friends, or family members. I will discuss how depression manifests in the workplace, the risk factors,  warning signs, and strategies for managing depression at work. I will also share how our mindset about stress can significantly influence our mental health outcomes.ReferencesDeady, M., Collins, D. A. J., Johnston, D. A., Glozier, N., Calvo, R. A., Christensen, H., & Harvey, S. B. (2022). A pilot evaluation of a smartphone application for workplace depression. International Journal of Environmental Research and Public Health, 17(6753), 1-14. https://doi.org/10.3390/ijerph17186753Greiner, B. A., & Arensman, E. (2022). The role of work in suicidal behavior - uncovering priorities for research and prevention. Scandinavian Journal of Work, Environment & Health, 48(6), 419–424. https://doi.org/10.5271/sjweh.4051 Huebschmann, N. A., & Sheets, E. S. (2020). The right mindset: Stress mindset moderates the association between perceived stress and depressive symptoms. Anxiety, Stress, & Coping, 1-8. https://doi.org/10.1080/10615806.2020.1736900LaMontagne, A. D., Åberg, M., Blomqvist, S., Glozier, N., Greiner, B. A., Gullestrup, J., Harvey, S. B., Kyron, M. J., Madsen, I. E. H., Hanson, L. M., Maheen, H., Mustard, C., Niedhammer, I., Rugulies, R., Smith, P. M., Taouk, Y., Waters, S., Witt, K., & King, T. L. (2024). Work-related suicide: Evolving understandings of etiology & intervention. American Journal of Industrial medicine, 67(8), 679–695. https://doi.org/10.1002/ajim.23624 Moon, J. Y., Choi, T. Y., Won, E. S., Won, G. H., Kim, S. Y., Lee, H. J., & Yoon, S. (2022). The relationship between workplace burnout and male depression symptom assessed by the Korean version of the Gotland Male Depression Scale. American Journal of Men's Health, 16(5), 1-13. https://doi.org/10.1177/15579883221123930Zadow, A. J., Dollard, M. F., Dormann, C., & Landsbergis, P. (2021). Predicting new major depression symptoms from long working hours, psychosocial safety climate and work engagement: A population‐based cohort study. BMJ Open, 11(6), e044133. https://doi.org/10.1136/bmjopen-2020-044133https://www.virtual-college.co.uk/resources/uk-suicides-could-be-work-related-research-suggestshttps://ahc.leeds.ac.uk/download/downloads/id/678/work-related_suicide_a_qualitative_analysis_of_recent_cases_with_recommendations_for_reform.pdfhttps://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/articles/suicidebyoccupation/england2011to2015

Welcome to Episode 37 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 37 of “The 2 View” – Pitfalls in Managing Pain in the ED with Sergey M. Motov, MD, FAAEM. Segment 1 Bachhuber MA, Hennessy S, Cunningham CO, Starrels JL. Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013. Am J Public Health. 2016;106(4):686-688. doi:10.2105/AJPH.2016.303061. https://pubmed.ncbi.nlm.nih.gov/26890165/ Bijur PE, Kenny MK, Gallagher EJ. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med. 2005;46(4):362-367. doi:10.1016/j.annemergmed.2005.03.010. https://pubmed.ncbi.nlm.nih.gov/16187470/ Evoy KE, Covvey JR, Peckham AM, Ochs L, Hultgren KE. Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS). Res Social Adm Pharm. 2019;15(8):953-958. doi:10.1016/j.sapharm.2018.06.018. https://pubmed.ncbi.nlm.nih.gov/31303196/ Kim HS, McCarthy DM, Hoppe JA, Mark Courtney D, Lambert BL. Emergency Department Provider Perspectives on Benzodiazepine-Opioid Coprescribing: A Qualitative Study. Acad Emerg Med. 2018;25(1):15-24. doi:10.1111/acem.13273. https://pubmed.ncbi.nlm.nih.gov/28791786/ Li Y, Delcher C, Wei YJ, et al. Risk of Opioid Overdose Associated With Concomitant Use of Opioids and Skeletal Muscle Relaxants: A Population-Based Cohort Study. Clin Pharmacol Ther. 2020;108(1):81-89. doi:10.1002/cpt.1807. https://pubmed.ncbi.nlm.nih.gov/32022906/ Peckham AM, Evoy KE, Covvey JR, Ochs L, Fairman KA, Sclar DA. Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population. Pharmacotherapy. 2018;38(4):436-443. doi:10.1002/phar.2096. https://pubmed.ncbi.nlm.nih.gov/29484686/ Smith RV, Havens JR, Walsh SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction. 2016;111(7):1160-1174. doi:10.1111/add.13324. https://pubmed.ncbi.nlm.nih.gov/27265421/ Suvada K, Zimmer A, Soodalter J, Malik JS, Kavalieratos D, Ali MK. Coprescribing of opioids and high-risk medications in the USA: a cross-sectional study with data from national ambulatory and emergency department settings. BMJ Open. 2022;12(6):e057588. Published 2022 Jun 16. doi:10.1136/bmjopen-2021-057588. https://pubmed.ncbi.nlm.nih.gov/35710252/ Segment 2 Caplan M, Friedman BW, Siebert J, et al. Use of clinical phenotypes to characterize emergency department patients administered intravenous opioids for acute pain. Clin Exp Emerg Med. 2023;10(3):327-332. doi:10.15441/ceem.23.018. https://pubmed.ncbi.nlm.nih.gov/37092185/ Connors NJ, Mazer-Amirshahi M, Motov S, Kim HK. Relative addictive potential of opioid analgesic agents. Pain Manag. 2021;11(2):201-215. doi:10.2217/pmt-2020-0048. https://pubmed.ncbi.nlm.nih.gov/33300384/ Fassassi C, Dove D, Davis A, et al. Analgesic efficacy of morphine sulfate immediate release vs. oxycodone/acetaminophen for acute pain in the emergency department. Am J Emerg Med. 2021;46:579-584. doi:10.1016/j.ajem.2020.11.034. https://pubmed.ncbi.nlm.nih.gov/33341323/ Irizarry E, Cho R, Williams A, et al. Frequency of Persistent Opioid Use 6 Months After Exposure to IV Opioids in the Emergency Department: A Prospective Cohort Study. J Emerg Med. Published online March 14, 2024. doi:10.1016/j.jemermed.2024.03.018. https://pubmed.ncbi.nlm.nih.gov/38821847/ Sapkota A, Takematsu M, Adewunmi V, Gupta C, Williams AR, Friedman BW. Oxycodone induced euphoria in ED patients with acute musculoskeletal pain. A secondary analysis of data from a randomized trial. Am J Emerg Med. 2022;53:240-244. doi:10.1016/j.ajem.2022.01.016. https://pubmed.ncbi.nlm.nih.gov/35085877/ Wightman R, Perrone J, Portelli I, Nelson L. Likeability and abuse liability of commonly prescribed opioids. J Med Toxicol. 2012;8(4):335-340. doi:10.1007/s13181-012-0263-x. https://pubmed.ncbi.nlm.nih.gov/22992943/ Segment 3 Anshus AJ, Oswald J. Erector spinae plane block: a new option for managing acute axial low back pain in the emergency department. Pain Manag. 2021;11(6):631-637. doi:10.2217/pmt-2021-0004. https://pubmed.ncbi.nlm.nih.gov/34102865/ Chauhan G, Burke H, Srinivasan SK, Upadhyay A. Ultrasound-Guided Erector Spinae Block for Refractory Abdominal Pain Due to Acute on Chronic Pancreatitis. Cureus. 2022;14(11):e31817. Published 2022 Nov 23. doi:10.7759/cureus.31817. https://pubmed.ncbi.nlm.nih.gov/36579238/ Dove D, Fassassi C, Davis A, et al. Comparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind Clinical Trial. Ann Emerg Med. 2021;78(6):779-787. doi:10.1016/j.annemergmed.2021.04.031. https://pubmed.ncbi.nlm.nih.gov/34226073/ Elkoundi A, Eloukkal Z, Bensghir M, Belyamani L, Lalaoui SJ. Erector Spinae Plane Block for Hyperalgesic Acute Pancreatitis. Pain Med. 2019;20(5):1055-1056. doi:10.1093/pm/pny232. https://pubmed.ncbi.nlm.nih.gov/30476275/ Finneran Iv JJ, Gabriel RA, Swisher MW, Berndtson AE, Godat LN, Costantini TW, Ilfeld BM. Ultrasound-guided percutaneous intercostal nerve cryoneurolysis for analgesia following traumatic rib fracture -a case series. Korean J Anesthesiol. 2020 Oct;73(5):455-459. doi: 10.4097/kja.19395. Epub 2019 Nov 5. PMID: 31684715; PMCID: PMC7533180. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533180/ Finneran JJ, Swisher MW, Gabriel RA, et al. Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. J Burn Care Res. 2020;41(1):224-227. doi:10.1093/jbcr/irz192. https://pubmed.ncbi.nlm.nih.gov/31714578/ Gabriel RA, Finneran JJ, Asokan D, Trescot AM, Sandhu NS, Ilfeld BM. Ultrasound-Guided Percutaneous Cryoneurolysis for Acute Pain Management: A Case Report. A A Case Rep. 2017;9(5):129-132. doi:10.1213/XAA.0000000000000546. https://pubmed.ncbi.nlm.nih.gov/28509777/ Herring AA, Stone MB, Nagdev AD. Ultrasound-guided abdominal wall nerve blocks in the ED. Am J Emerg Med. 2012;30(5):759-764. doi:10.1016/j.ajem.2011.03.008. https://pubmed.ncbi.nlm.nih.gov/21570238/ Kampan S, Thong-On K, Sri-On J. A non-inferiority randomized controlled trial comparing nebulized ketamine to intravenous morphine for older adults in the emergency department with acute musculoskeletal pain. Age Ageing. 2024;53(1):afad255. doi:10.1093/ageing/afad255. https://pubmed.ncbi.nlm.nih.gov/38251742/ Mahmoud S, Miraflor E, Martin D, Mantuani D, Luftig J, Nagdev AD. Ultrasound-guided transverse abdominis plane block for ED appendicitis pain control. Am J Emerg Med. 2019;37(4):740-743. doi:10.1016/j.ajem.2019.01.024. https://pubmed.ncbi.nlm.nih.gov/30718116/ McCahill RJ, Nagle C, Clarke P. Use of Virtual Reality for minor procedures in the Emergency Department: A scoping review. Australas Emerg Care. 2021;24(3):174-178. doi:10.1016/j.auec.2020.06.006. https://pubmed.ncbi.nlm.nih.gov/32718907/ Nguyen T, Mai M, Choudhary A, et al. Comparison of Nebulized Ketamine to Intravenous Subdissociative Dose Ketamine for Treating Acute Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind, Double-Dummy Controlled Trial. Ann Emerg Med. Published online May 2, 2024. doi:10.1016/j.annemergmed.2024.03.024. https://pubmed.ncbi.nlm.nih.gov/38703175/ Sikka N, Shu L, Ritchie B, Amdur RL, Pourmand A. Virtual Reality-Assisted Pain, Anxiety, and Anger Management in the Emergency Department. Telemed J E Health. 2019;25(12):1207-1215. doi:10.1089/tmj.2018.0273. https://pubmed.ncbi.nlm.nih.gov/30785860/ Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Training as imagined?, sim for faster stroke treatment, simulation after key events, Implementing TALK for clinical debriefing.  Another great month on Simulcast.  The articles: -  Kerins, J., Ralston, K., Stirling, S.A. et al. Training as imagined? A critical realist analysis of Scotland's internal medicine simulation programme. Adv Simul 9, 27 (2024)  Ajmi SC, Kurz M, Lindner TW, et al. Does clinical experience influence the effects of team simulation training in stroke thrombolysis? A prospective cohort study. BMJ Open 2024;14:e086413  Diaz-Navarro, C., Jones, B., Pugh, G. et al. Improving quality through simulation; developing guidance to design simulation interventions following key events in healthcare. Adv Simul 9, 30 (2024).  Diaz-Navarro C, Enjo-Perez I, Leon-Castelao E, Hadfield A, Nicolas-Arfelis JM, Castro-Rebollo P. Implementation of the TALK© clinical self-debriefing tool in operating theatres: a single-centre interventional study. Br J Anaesth. 2024 Jul 29:S0007-0912(24)00413-6.    And also mentioned on the podcast   The Self Development Module on ‘Introduction to Quality Improvement'  Happy listening!    And… Date Claimers    The Victorian Translational SIMposium  6th September, Melbourne . Details and registration here     Simulation Reconnect is on again   Bond University, Wednesday 27th November. Registration here  

Cost-effectiveness of strength exercise or aerobic exercise compared with usual care for patients with knee osteoarthritis: secondary results from a multiarm randomised controlled trial in Norway Killingmo RM, Øiestad BE, Risberg MA, et al. BMJ Open. 2024;14(5):e079704. doi:10.1136/bmjopen-2023-079704 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Remember when they were coming to take your gas stove away? Every so often a study about the effects of air pollution on health goes viral, and we're reminded again that seemingly innocuous objects—like your kitchen cooker—could be bad for us in unexpected ways. How bad is air pollution? And is it getting any better?In this episode of The Studies Show, Tom and Stuart look into the science of air pollution, trying to separate correlation from causality, and working out what scientists mean when they say that deaths are “attributable” to something (it's more complicated than you think!).The Studies Show is brought to you by Works in Progress magazine. We usually mention their long-form pieces at worksinprogress.co, but they also have a Substack newsletter at worksinprogress.news with shorter articles on the same topics. We commend it to you, and thank Works in Progress for sponsoring the podcast.Show notes* Recent news about “Ella's Law” in the UK* Tom's 2019 Unherd article on air pollution* “Death risk from London's toxic air sees ‘utterly horrifying' rise for second year running”* The Our World In Data “Deaths by Risk Factor” graph* 2024 BMJ Open article about the health risks of coal power stations* Dynomight's long article on air quality* The 1952 “Great Smog of London”* More useful Our World In Data articles:* An explainer on “attributable fractions” and summing up multiple risk factors* On indoor air pollution* Deaths from outdoor pollution* Death rate from outdoor pollution* Deaths from outdoor pollution vs. GDP per capita* The WHO calls indoor air pollution “the world's single largest environmental health risk”* More on attributable fractions, with some examples* Example of an experimental study on the effects of air pollution* The article that sparked the Great Cooker Controversy of 2023* Example of the media coverage at the time* Biden forced to rule out a ban on gas cookers* Recent story on how there's “no safe level” of PM2.5* Based on this 2024 paper in the BMJ* How policy interventions can reduce (and have reduced) air pollution* London report on the effect of ULEZCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

Today we provide you with an update on the sexually transmitted infection: Trichomonas vaginalis, a protozoan which infects the vagina, urethra and paraurethral glands. It is an uncommon cause of vaginal discharge and penile urethritis and can persist for a long time if left untreated. Up to 50% of people with vaginal infections and especially people with urethral infections remain asymptomatic. Persistent trichomonas infection has been associated with facilitating the transmission of human immunodeficiency virus (HIV) and adverse poor reproductive health outcomes. Dr Christina Munzy, Professor in Infectious Diseases at University of Alabama, Birmingham, USA, will present on published clinical trial data on novel treatment against trichomoniasis. Relevant publications: Van Gerwen OT, Aaron KJ, Schroeder J, et al. Spontaneous resolution of Trichomonas vaginalis infection in men. Sexually Transmitted Infections. Published Online First: 27 June 2024. Muzny CA, Van Gerwen OT, Kaufman G, Chavoustie S. Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data. BMJ Open. 2023;13:e072071 Kissinger PJ, Gaydos CA, Seña AC, McClelland RS, Soper, Secor WE, Legendre D, Workowski KA, Muzny CA, Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines, Clinical Infectious Diseases, Clinical Infectious Diseases, Volume 74, Issue Supplement_2, 15 April 2022 Howe K and Kissinger PJ. Single-dose compared with multidose metronidazole for the treatment of trichomoniasis in women: a meta-analysis. Sex Transm Dis 2017; 44: 29–34. Kissinger P, Muzny CA, Mena LA, et al. Single-dose versus 7- day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial. Lancet Infect Dis 2018; 18: 1251–1259. Sherrard J, Pitt R, Hobbs KR, Maynard M, Cochrane E, Wilson J, Tipple C. British Association for Sexual Health and HIV (BASHH) United Kingdom national guideline on the management of Trichomonas vaginalis 2021. Int J STD AIDS. 2022 Jul;33(8):740-750. STI Guidelines Australia - Trichomoniasis Host: Dr Fabiola Martin, STI BMJ Podcast editor, a Sexual Health, HIV and HTLV Specialist, Canberra & University of Queensland, Brisbane, Australia Guest: Dr Christina Munzy, Professor in Infectious Diseases at University of Alabama, Birmingham, USA

From time to time we rebroadcast popular episodes from our past catalogue. This week we bring you an episode from season 4, where Gaylea Fritsch, Vic Branch Professional Education committee member, chats with Chris Payten, Advanced Speech Pathologist at Gold Coast Hospital and PhD candidate at the University of Sydney. Chris explores his current PhD research in the area of voice disorder classification and implementing a primary telehealth assessment model for voice disorders. Resources:  NAIDOC Week- https://www.naidoc.org.au/ NAIDOC Week event finder- https://www.naidoc.org.au/local-events/local-naidoc-week-events New resources from Chris: Payten.C., et al. Evidenced Based Framework for Voice Disorder Classification- https://ars.els-cdn.com/content/image/1-s2.0-S089219972200039X-mmc1_lrg.jpg Resources from original broadcast: Chris's telehealth study protocol can be accessed here: Payten CL, Nguyen DD, Novakovic D, O'Neill J, Chacon A, Weir KA, and Madill CJ. Telehealth voice assessment by speech language pathologists during a global pandemic using principles of a primary contact model: an observational cohort study protocol. BMJ Open 2022;12:e052518. doi: 10.1136/bmjopen-2021-052518 bmjopen.bmj.com/content/12/1/e052518 Payten CL, Chiapello G, Weir KA and Madill CJ. Frameworks, Terminology and Definitions used for the Classification of Voice Disorders: A Scoping Review. Journal of Voice. https://pubmed.ncbi.nlm.nih.gov/35317970/ For further information, Chris can be contacted on: Christopher.Payten@health.qld.gov.au Speech Pathology Australia acknowledge the Traditional Custodians of lands, seas and waters throughout Australia, and pay respect to Elders past and present. We recognise that the health and social and emotional wellbeing of Aboriginal and Torres Strait Islander peoples are grounded in continued connection to culture, country, language and community and acknowledge that sovereignty was never ceded.

Ellen Langer is a psychologist at Harvard who studies the mind-body connection. She's published some of the most remarkable scientific findings Steve has ever encountered. Can we really improve our physical health by changing our mind? SOURCE:Ellen Langer, professor of psychology at Harvard University. RESOURCES:Brave New Words: How AI Will Revolutionize Education (and Why That's a Good Thing), by Sal Khan (2024)."F.D.A.'s Review of MDMA Cites Health Risks and Study Flaws," by Andrew Jacobs and Christina Jewett (The New York Times, 2024).The Mindful Body: Thinking Our Way to Chronic Health, by Ellen Langer (2023)."Physical Healing as a Function of Perceived Time," by Peter Aungle and Ellen Langer (Nature: Scientific Reports, 2023)."Aging as a Mindset: A Study Protocol to Rejuvenate Older Adults With a Counterclockwise Psychological Intervention," by Francesco Pagnini, Cesare Cavalera, Ellen Langer, et al. (BMJ Open, 2019).Counterclockwise: Mindful Health and the Power of Possibility, by Ellen Langer (2009)."Mind-Set Matters: Exercise and the Placebo Effect," by Alia Crum and Ellen Langer (2007)."The Effects of Choice and Enhanced Personal Responsibility for the Aged: A Field Experiment in an Institutional Setting," by Ellen Langer and Judith Rodin (Journal of Personality and Social Psychology, 1976). EXTRAS:"The Future of Therapy Is Psychedelic," by People I (Mostly) Admire (2023)."Extra: An Update on the Khan World School," by People I (Mostly) Admire (2023)."Is This the Future of High School?" by People I (Mostly) Admire (2022)."What It Takes to Know Everything," by People I (Mostly) Admire (2022)."Sal Khan: 'If It Works for 15 Cousins, It Could Work for a Billion People,'" by People I (Mostly) Admire (2021)."Greg Norman & Mark Broadie: Why Golf Beats an Orgasm and Why Data Beats Everything," by People I (Mostly) Admire (2021)."Caverly Morgan: 'I Am Not This Voice. I Am Not This Narrative,'" by People I (Mostly) Admire (2020)."Does 'As If' Thinking Really Work?" by No Stupid Questions (2020)."Havana Wild Weekend," S28.E7 of The Simpsons (2016). 

Listen to Dr Rohan Mehra, RCP clinical education fellow, (Infectious diseases/microbiology SPR) and Dr Mumtaz Patel, as they shine a spotlight on differential attainment in healthcare. This is a pervasive issue within UK healthcare which requires work from everyone. Here Rohan and Mumtaz illustrate the issue, how it impacts people and what you can do to try and make a difference.  Dr Mumtaz Patel is a consultant in nephrology in Manchester as well as Senior censor and Vice President for education for the RCP. Mumtaz led nationally on the research around Differential Attainment for over 5 years and has led cross-collaborative research across organisations such as GMC, NHSE, royal colleges and within different specialties with a focus on earlier interventions and support to improve educational outcomes and trainee experience. Mumtaz has helped produce national guidance around supporting trainers and trainees in addressing and narrowing the Differential attainment gap. This work has had national and international recognition with presentations at multiple conferences. Resources:GMC: tackling differential attainment.https://www.gmc-uk.org/education/standards-guidance-and-curricula/guidance/tackling-differential-attainmentAcademic papers highlighting differential attainment and steps that need taken:Woolf K, Potts HW. Ethnicity and academic performance in UK-trained doctors and medical students: systematic review and meta-analysis. BMJ 2011;342:d901.Regan de Bere S, Nunn S, Nasser M. Understanding differential attainment across medical training pathways: a rapid review of the literature Final report prepared for The General Medical Council. 2015. https://www.gmc-uk.org/-/media/documents/gmc-understanding-differential-attainment_pdf-63533431.pdfWoolfe K, Rich A, Viney R, Needleman S, Griffin A. Perceived causes of differential attainment in UK postgraduate medical training: a national qualitative study. BMJ Open 2016;6:e013429https://www.gmc-uk.org/education/14105.aspHawkridge A, Molyneux D. (2019) A description and evaluation of an educational programme for North West England GP trainees who have multiple fails in the Clinical Skills Assessment (CSA). Education for Primary Care. 30(3):167-172. https://www.gmc-uk.org/-/media/documents/gmc-da-final-report-success-factors-in-training-211119_pdf-80914221.pdfJeremy Brown, Liam Jenkins, John Sandars, Julie Bridson, Mumtaz Patel (2023) Evaluation of the Impact of the Workshop ‘EQiT – Embedding Compassionate, Courageous, Cross-cultural Conversations into Training' General Medical CouncilJeremy Brown, Liam Jenkins, John Sandars, Julie Bridson, Mumtaz Patel (2023) Evaluation of the impact of the Royal College of Psychiatrists Clinical Assessment of Skill and Applied Knowledge masterclass on reducing the attainment gap General Medical Council Academy of Medical Royal Colleges, 2023 Principles for exam preparation, feedback and support for candidates to address the awarding gap.Patel, M. Differential Attainment and implementing successful strategies, RCP commentary 2023, https://70b706f2.flowpaper.com/CommAugust2023v2/#page=18 Music by Bensound.comThis episode was funded by Vertex Pharmaceuticals (Europe) Limited. Vertex had no involvement in the creation and elaboration of this episode and all views and opinions expressed by the presenter and guests are solely their own.

Proton pump inhibitors, or PPIs, are a class of popular drugs that reduce the amount of acid produced in the stomach. They are often the first-line treatment for conditions related to acid, such as esophagitis, non-erosive reflux disease, and peptic ulcer disease. We talk about PPIs and dementia with Misha Kogan, MD, ABIOM, RCST, medical director of the GW Center of Integrative Medicine and associate professor of Medicine here at GW. Studies show that people who take proton pump inhibitors (PPIs) for more than four years and are 45 or older have a 33% higher risk of developing dementia than those who have never taken PPIs. An expert on neurodegenerative diseases, Dr. Kogan completed the Geriatric Fellowship at GW. He is the chief editor of the first definitive textbook on Integrative Medicine and aging, “Integrative Geriatric Medicine,” part of Andrew Weil Integrative Medicine Library series. Dr. Kogan is also on the faculty of the GW Institute for Brain Health and Dementias; associate director of the Geriatrics Fellowship Program at GW; and founder and director othe George Washington University Integrative Geriatrics Fellowship Track. ◘ Related Content Institute for Brain Health and Dementia https://brainhealth.gwu.edu/ Choudhury A, Jena A, Jearth V, et al. Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2023;17(5):479-487. doi:10.1080/17474124.2023.2204229 https://pubmed.ncbi.nlm.nih.gov/37060552/ Gommers LMM, Hoenderop JGJ, de Baaij JHF. Mechanisms of proton pump inhibitor-induced hypomagnesemia. Acta Physiol (Oxf). 2022;235(4):e13846. doi:10.1111/apha.13846 https://pubmed.ncbi.nlm.nih.gov/35652564/ Geng T, Chen JX, Zhou YF, et al. Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2023;108(6):e216-e222. doi:10.1210/clinem/dgac750 https://pubmed.ncbi.nlm.nih.gov/36573284/ Liu W, Wang J, Wang M, Wang M, Liu M. Association of proton pump inhibitor use with risk of kidney stones: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (2007-2018). BMJ Open. 2023;13(10):e075136. Published 2023 Oct 16. doi:10.1136/bmjopen-2023-075136 https://pubmed.ncbi.nlm.nih.gov/37844987/ Gao S, Song W, Lin T, et al. Prolonged Use of Proton Pump Inhibitors, but Not Histamine-2 Receptor Antagonists, Is Associated With Lower Bone Mineral Density in Males Aged Over 70. Front Med (Lausanne). 2021;8:725359. Published 2021 Aug 23. doi:10.3389/fmed.2021.725359 https://pubmed.ncbi.nlm.nih.gov/34497815/ ◘ Transcript https://bit.ly/3V1BoJT ◘ This podcast features the song “Follow Your Dreams” (freemusicarchive.org/music/Scott_Ho…ur_Dreams_1918) by Scott Holmes, available under a Creative Commons Attribution-Noncommercial (01https://creativecommons.org/licenses/by-nc/4.0/) license. ◘ Disclaimer: The content and information shared in GW Integrative Medicine is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in GW Integrative Medicine represent the opinions of the host(s) and their guest(s). For medical advice, diagnosis, and/or treatment, please consult a medical professional.

If you're like me, you want to see the evidence. There is a lot of talk out there about how “fertility mindset” can help you conceive. But is there actual research to back that up? You may be wondering if it's a bunch of woo-woo hocus-pocus or if there is actual science to back up the claims. If you're curious about this approach because something in you thinks it could help, but you're also skeptical because it's outside the scope of typical medical protocol, then this episode will assuage your concerns. I'm bringing out the research from medical journals and explaining how findings suggest that women who participate in mind/body programs can be up to twice as likely to conceive as women who don't. That's a pretty exciting fact! Join me today as we break all this down. And, after you listen o the show, check out the citations down below. For fertility support, inspiration and community, follow me @badassfertility CITATIONS Clifton J, Parent J, Seehuus M, Worrall G, Forehand R, Domar A. An internet-based mind/body intervention to mitigate distress in women experiencing infertility: A randomized pilot trial. PLoS One. 2020 Mar 18;15(3):e0229379. doi: 10.1371/journal.pone.0229379. PMID: 32187236; PMCID: PMC7080396. Domar, A. et al. “Impact of a group Mind/Body Intervention on Pregnancy Rates in IVF Patients,” Fertility and Sterility, vol 75, no. 7: pp 2269 – 2273 (June 2011) Frederiksen Y, Farver-Vestergaard I, Skovgård NG, et al Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis BMJ Open 2015;5:e006592. doi: 10.1136/bmjopen-2014-006592 Rooney KL, Domar AD. The relationship between stress and infertility. Dialogues Clin Neurosci. 2018 Mar;20(1):41-47. doi: 10.31887/DCNS.2018.20.1/klrooney. PMID: 29946210; PMCID: PMC6016043.

In this episode, Dr. Mark Hoffman hosts Dr. Jan Baekelandt, a gynecologic surgeon from Mechelen, Belgium, to discuss a novel gynecologic surgery approach known as vaginal natural orifice transluminal endoscopic surgery (vNOTES). --- SHOW NOTES This technique involves entering the pelvic cavity through the vaginal lumen, eliminating the need for abdominal incisions and promoting a less invasive procedure. Dr. Jan Baekelandt explains that during his career this approach originated from the single-side surgery technique, gradually evolving into a fully transvaginal procedure. He highlights that the advanced tools required for vaginal surgeries now offer equivalent visualization and hemostatic control as laparoscopic techniques, while providing the added benefit of reduced invasiveness. The benefits of vNOTES for patients are discussed, including findings from two randomized control trials comparing vNOTES hysterectomy and adnexectomy to laparoscopic approaches. The results indicate non-inferiority, reduced postoperative pain, decreased analgesic use, and shorter hospital stays for vNOTES. Complications were also lower in the hysterectomy trial. Notably, the vNOTES technique especially benefited patients who were obese, had undergone prior abdominal surgeries, or had large uteruses. Jan underscores the significance of technique standardization to facilitate teaching and complication avoidance. He acknowledges vNOTES-specific complications, such as a higher cystotomy rate, but notes a lower ureter damage rate. However, he cautions that vNOTES might not be suitable for certain patients, like those with endometriosis, prior pelvic inflammatory disease or pelvic abscesses. The potential impact of vNOTES on non-hysterectomy surgeries, future deliveries, and sexual function is briefly discussed, though data in these areas remain limited. Dr. Jan Baekelandt is hopeful that more evidence will emerge to guide physicians. He shares that, based on available data and his own experience, vaginal deliveries following vNOTES have generally proceeded without complications, without a notable increase in cesarean sections or vaginal tears. He notes that to protect sexual function, surgeons should take care to make incisions away from the posterior cervical fornix to avoid subsequent dyspareunia for their patients. The episode concludes with Jan emphasizing the importance of formal training and starting with simpler cases to build proficiency and confidence. He asserts that the best technique for a surgeon is the one that instills confidence in keeping patients safe. --- RESOURCES Baekelandt J, De Mulder PA, Le Roy I, Mathieu C, Laenen A, Enzlin P, Weyers S, Mol BW, Bosteels JJ. HALON-hysterectomy by transabdominal laparoscopy or natural orifice transluminal endoscopic surgery: a randomised controlled trial (study protocol). BMJ Open. 2016 Aug 12;6(8):e011546. doi: 10.1136/bmjopen-2016-011546. PMID: 27519922; PMCID: PMC4985989. Baekelandt JF, De Mulder PA, Le Roy I, Mathieu C, Laenen A, Enzlin P, Weyers S, Mol BWJ, Bosteels JJA. Transvaginal natural orifice transluminal endoscopic surgery (vNOTES) adnexectomy for benign pathology compared with laparoscopic excision (NOTABLE): a protocol for a randomised controlled trial. BMJ Open. 2018 Jan 10;8(1):e018059. doi: 10.1136/bmjopen-2017-018059. PMID: 29326183; PMCID: PMC5780723.

Happy birthday Adam! Join us for this special birthday Pod where we discuss a fascinating new meta-analysis on the association of PPIs and Dementia. Learn about the study's results, methods, a rabbit hole about prediction intervals, and Adam's Tupperware approach to confidence intervals.  Learn more and become a member on https://drjournalclub.com/PPIs and Barrett's Continuing Education Course: https://drjournalclub.com/continuing-education/Ahn N, Nolde M, Krause E, Güntner F, Günter A, Tauscher M, Gerlach R, Meisinger C, Linseisen J, Baumeister SE, Rückert-Eheberg IM. Do proton pump inhibitors increase the risk of dementia? A systematic review, meta-analysis and bias analysis. Br J Clin Pharmacol. 2023 Feb;89(2):602-616. doi: 10.1111/bcp.15583. Epub 2022 Nov 23. PMID: 36331350.Kumar R, Kumar A, Nordberg A, Långström B, Darreh-Shori T. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia. Alzheimers Dement. 2020 Jul;16(7):1031-1042. doi: 10.1002/alz.12113. Epub 2020 May 8. PMID: 32383816.Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011 Feb 10;342:d549. doi: 10.1136/bmj.d549. PMID: 21310794.IntHout J, Ioannidis JP, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016 Jul 12;6(7):e010247. doi: 10.1136/bmjopen-2015-010247. PMID: 27406637; PMCID: PMC4947751.Learn more and become a member at www.DrJournalClub.comCheck out our complete offerings of NANCEAC-approved Continuing Education Courses.

Dr. Mark Neuman and Dr. Sam Falkson join the show to discuss the literature around risks of regional versus general anesthesia for postoperative delirium. Dr. Neuman is the founding Director of the Center for Perioperative Outcomes Research and Transformation and Professor of Anesthesiology at Penn Medicine. Dr. Sam Falkson is an anesthesia resident at the Massachusetts General Hospital. This podcast was recorded as part of the Depth of Anesthesia podcast elective. Thanks for listening! If you enjoy our content, leave a 5-star review on Apple Podcasts and share our content with your colleagues. — Follow us on Instagram @DepthofAnesthesia and on Twitter (X) @DepthAnesthesia for podcast and literature updates. Email us at depthofanesthesia@gmail.com with episode ideas or if you'd like to join our team. Music by Stephen Campbell, MD. — References Guay J, Parker MJ, Gajendragadkar PR, Kopp S. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2016;2(2):CD000521. Ravi B, Pincus D, Choi S, Jenkinson R, Wasserstein DN, Redelmeier DA. Association of duration of surgery with postoperative delirium among patients receiving hip fracture repair. JAMA Netw Open. 2019;2(2):e190111. Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. BMJ Open. 2018;8(12):e020757. Zheng X, Tan Y, Gao Y, Liu Z. Comparative efficacy of Neuraxial and general anesthesia for hip fracture surgery: a meta-analysis of randomized clinical trials. BMC Anesthesiol. 2020 Jun 30;20(1):162. Neuman MD, Feng R, Carson JL, et al. Spinal anesthesia or general anesthesia for hip surgery in older adults. N Engl J Med. 2021;385(22):2025-2035. Rathmell JP, Avidan MS. Patient-centered outcomes after general and spinal anesthesia. N Engl J Med. 2021 Nov 25;385(22):2088–9. Stone AB, Poeran J, Memtsoudis SG. There remains a role for neuraxial anesthesia for hip fracture surgery in the post-REGAIN era. Reg Anesth Pain Med. 2023 Aug;48(8):430-432. doi: 10.1136/rapm-2022-104071. Epub 2023 Mar 28. PMID: 36977527. Li T, Li J, Yuan L, et al. Effect of regional vs general anesthesia on incidence of postoperative delirium in older patients undergoing hip fracture surgery: the raga randomized trial. JAMA. 2022;327(1):50-58.

Do you always feel out of touch with yourself, school, work, or your passions? You may be experiencing burnout. Once you go a long time without addressing this issue, it may spiral into more issues such as depression and low self-esteem. Here are a few signs that you're burnt out. Disclaimer: This is a disclaimer that this video is for informative purposes only. It is not intended to diagnose or treat any condition. Please reach out to a qualified healthcare provider or mental health professional if you are struggling. Some people mistake burnout for laziness, but how do we tell the difference? Watch this video to learn more: https://youtu.be/MLuJ249WnkE Writer: Mary Li Chamae G. Quiachon Script Editor: Isadora Ho Script Manager: Kelly Soong Voice: Amanda Silvera Animator: Hannah Ralden YouTube Manager: Cindy Cheong REFERENCES: GoodTherapy. (2018, August 20). Isolation. www.goodtherapy.org/learn-about-therapy/issues/isolation LearnVest. (2021, June 30). 10 Signs You're Burning Out — And What To Do About It. Forbes. www.forbes.com/sites/learnvest/2013/04/01/10-signs-youre-burning-out-and-what-to-do-about-it/?sh=4388750625b4 Mayo Clinic. (2016, October 15). Insomnia – Diagnosis and treatment – Mayo Clinic. www.mayoclinic.org/diseases-conditions/insomnia/diagnosis-treatment/drc-20355173 Metlaine, A., Sauvet, F., Gomez-Merino, D., Elbaz, M., Delafosse, J., Leger, D., & Chennaoui, M. (2017, January 1). Association between insomnia symptoms, job strain and burnout syndrome: a cross-sectional survey of 1300 financial workers. BMJ Open. bmjopen.bmj.com/content/7/1/e012816 Roberts, C. (2019, October 10). 7 important signs you have burnout — and how to fix it. CNET. www.cnet.com/health/signs-you-have-burnout/ Smith, M., M. A., Segal, J., Ph. D., & Robinson, L. (2021, July 15). Burnout Prevention and Treatment. HelpGuide.Org. https://www.helpguide.org/articles/stress/burnout-prevention-and-recovery.htm Solving Procrastination. (n.d.). Why People Procrastinate: The Psychology and Causes of Procrastination. Retrieved from solvingprocrastination.com/why-people-procrastinate/ Soong, J. (2010, December 6). Depression Traps: Social Withdrawal, Rumination, and More. WebMD. www.webmd.com/depression/features/depression-traps-and-pitfalls WebMD. (n.d.). Signs You're Burned Out. Retrieved from www.webmd.com/balance/ss/slideshow-signs-burnout

Five-year follow-up of patients with knee osteoarthritis not eligible for total knee replacement: results from a randomised trial. Larsen JB, Roos EM, Laursen M, et al. BMJ Open. 2022;12(11):e060169. doi:10.1136/bmjopen-2021-060169 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

Hormonal birth control is linked with altered mood states, including anxiety and depression as well as exaggerated responses to stress.  Sponsored Message: Support your sleep, mood and metabolic health with MyoRelax and Calm by MYOXCIENCE: https://bit.ly/myo-relax-sleep-blend Use code podcast at checkout to save Link to imagers and articles: https://bit.ly/44HIPZM Time Stamps:  00:00 Altered mood states are linked with hormonal birth control. 00:50 IUD's, other than copper, contain progestins and some have estrogens. 02:00 Elevated depression and stress scores, elevated CRP, and plasma cortisol, are found from hormonal birth control. 04:00 Exaggerated basal neuroendocrine and inflammatory profiles are found with hormonal contraceptive users. 04:20 Hormone users had double the amount of cortisol compared to non-users. 04:40 Synthetic progestins and estrogens are not the same as biologically identical progesterone and estradiol. 07:20 Depression increases your risk from dying from all causes, particularly from cardiovascular disease. 07:45 Neurotransmitter GABA is sensitive to changes in progesterone. 10:50 Neuroactive steroid hormones and the HPAG axis are altered with synthetic hormonal contraceptives. 13:10 History of psychiatric illness increases likelihood of poor mental health while using hormonal contraception. 14:30 Explore birth control alternatives.   Studies Mentioned:   1.Skovlund, C. W., Mørch, L. S., Kessing, L. V. & Lidegaard, Ø. Association of Hormonal Contraception With Depression. Jama Psychiat73, 1154 (2016).   2.Lewis, C. A. et al. Effects of Hormonal Contraceptives on Mood: A Focus on Emotion Recognition and Reactivity, Reward Processing, and Stress Response. Curr Psychiat Rep 21, 115 (2019).   3.Elsayed, M. et al. The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review. World J Biological Psychiatry 1–19 (2022) doi:10.1080/15622975.2022.2145354.   4.Raeder, F. et al. Do oral contraceptives modulate the effects of stress induction on one-session exposure efficacy and generalization in women? Psychopharmacology 240, 1075–1089 (2023).   5.Lacasse, J. M., Ismail, N. & Tronson, N. C. Editorial overview: Hormonal contraceptives and the brain: A call for translational research. Front Neuroendocrin 69, 101063 (2023).   6.Martell, S., Marini, C., Kondas, C. A. & Deutch, A. B. Psychological side effects of hormonal contraception: a disconnect between patients and providers. Contracept Reproductive Medicine 8, 9 (2023).   7.Zettermark, S. et al. Population heterogeneity in associations between hormonal contraception and antidepressant use in Sweden: a prospective cohort study applying intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Bmj Open 11, e049553 (2021).

FOURIER authors' response, a possible practice-changing paper in electrophysiology, and the ATLAS and CAPLA trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. FOURIER Authors Respond Recount of FOURIER Data Finds Higher Mortality With Evolocumab; Trialists Push Back https://www.medscape.com/viewarticle/986634 Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data https://bmjopen.bmj.com/content/12/12/e060172 Letter to the Editor RE: "Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data". BMJ Open https://bmjopen.bmj.com/content/12/12/e060172.responses#letter-to-the-editor-re-restoring-mortality-data-in-the-fourier-cardiovascular-outcomes-trial-of-evolocumab-in-patients-with-cardiovascular-disease-a-reanalysis-based-on-regulatory-data-bmj-open-2022123060172 Risk of selection bias assessment in the NINDS rt-PA stroke study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202115/ Methodological survey of missing outcome data in an alteplase for ischemic stroke meta-analysis https://doi.org/10.1111/ane.13656 II. A Potential Practice-Changing Paper in Cardiac Pacing Novel 'Cure' May Avert Lead Extraction in CIED Pocket Infections https://www.medscape.com/viewarticle/986762 Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections https://doi.org/10.1016/j.jacc.2022.10.022 Treatment of Localized Implantable Cardiac Device Pocket Infections https://doi.org/10.1016/j.jacc.2022.11.018 III. ATLAS Trial Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations https://doi.org/10.7326/M22-1566 Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1915932 Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/10.1056/NEJMc2034917 IV. CAPLA Published CAPLA Shows Limits of Further Ablation Post PVI in Persistent AF https://www.medscape.com/viewarticle/986901 Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800186 Catheter Ablation for Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2800200 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net