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Welcome to the Oncology Brothers podcast! In this episode, we were joined by Dr. Rutika Mehta, a GI medical oncologist from Weill Cornell. Together, we dived into the current treatment landscape for advanced metastatic gastroesophageal junction (GEJ) and gastrointestinal carcinoma, with a special focus on HER2-positive disease. Episode Highlights: • Overview of recent advancements in the treatment of resectable disease, including the approval of Durvalumab in perioperative settings. • Discussion on the importance of biomarker testing, including HER2, PD-L1, MMR, and Claudin 18.2, in determining treatment options. • Insights into frontline treatment strategies for HER2-positive patients, including the role of trastuzumab and the addition of pembrolizumab based on PD-L1 status. • The significance of retesting HER2 expression upon disease progression and the implications for treatment decisions. • Exploration of emerging therapies like TDXd and Zanidatamab, and their potential impact on the treatment landscape. • Considerations for managing side effects and the importance of treatment sequencing in palliative care. Join us for an informative discussion that aims to keep community oncologists up to date in this ever-evolving field of cancer treatment. Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Don't forget to subscribe for more episodes covering treatment algorithms, FDA approvals, and conference highlights! Accreditation/Credit Designation Physicians' Education Resource®, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Physicians' Education Resource®, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Acknowledgment of Commercial Support This activity is supported by an educational grant from Jazz Pharmaceuticals, Inc. Link to gain CME credits from this activity: https://www.gotoper.com/courses/biomarker-testing-in-her2-gea-diagnosis-and-treatment-implications #HER2GastricCancer #GastricCancer #BiomarkerTesting #OncologyBrothers #GIOncology #CME
*The Texas grain harvest is almost done. *Highly Pathogenic Avian Influenza is showing up in wild birds. *The Texas Wheat Producers Board presented the Texas Wheat Legacy Award to wheat breeder Dr. Jackie Rudd. *Regaining access to China is good news for Texas sorghum growers. *High input costs continue, with fertilizer playing a major role. *Regenerative agriculture is getting a funding boost. *Many Texas soils are acidic. *Gastric ulcers are a major problem in horses.
In this episode of The Oncology Brothers, we dived into the pivotal study of MATTERHORN, which explored the addition of Durvalumab to perioperative FLOT chemotherapy for patients with resectable gastric and gastroesophageal junction adenocarcinoma. Join us as we welcome Dr. Yelena Y. Janjigian, a medical oncologist from Memorial Sloan Kettering and the lead author of the MATTERHORN study. Dr. Janjigian shared insights on the study's design, findings, and the implications for clinical practice, including: • The significance of the study in the context of recent FDA approvals and treatment advancements. • Key survival data, including a three-year overall survival rate of 68.6% with Durvalumab. • The feasibility of combining immunotherapy with chemotherapy and impact on surgical outcomes. • Management of side effects and clinical pearls for practitioners. We also discussed the potential for extrapolating this data to esophageal adenocarcinoma and the role of PD-L1 status in treatment decisions. Whether you're a seasoned oncologist or just starting in the field, this episode is packed with valuable information to help you provide the best care for your patients. Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Don't forget to like, share, and subscribe for more practice-changing updates in oncology! #MATTERHORN #GastricCancer #Immunotherapy #Durvalumab #OncologyBrothers #GIOncology
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/ZSR865. CME/AAPA credit will be available until October 29, 2026.To Glycemia and Beyond: Managing Cardiovascular Risk in People With Type 2 Diabetes Using Incretin-Based Therapies In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
Host: Jennifer Caudle, DO Guest: Samuel Klempner, MD Guest: Nataliya Uboha, MD, PhD Testing for biomarkers like PD-L1, HER2, claudin 18.2, and FGFR2b is reshaping our approach to first-line therapy in advanced gastric and gastroesophageal junction cancers. Alongside biomarker profiling, we must also weigh practical considerations around efficacy, toxicity, and patient-specific factors when selecting treatment. Joining Dr. Jennifer Caudle to explore how we can optimize our first-line treatment selection are Drs. Samuel Klempner and Dr. Nataliya Uboha. Dr. Klempner is an Associate Professor of Medicine at Harvard Medical School, and Dr. Uboha is an Associate Professor in the Division of Hematology and Oncology in the Department of Medicine at the University of Wisconsin.
Fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) is an emerging biomarker present in about 38% of patients with advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. In this episode, CANCER BUZZ speaks with Nataliya Uboha, MD, PhD, a medical oncologist at University of Wisconsin Health, about current recommendations for biomarker testing in this population, emerging biomarkers such as FGFR2b, and how multidisciplinary collaboration can ensure patients receive timely biomarker testing. CANCER BUZZ also interviews Wendi Waugh, BS, RT(R)(T), CMD, ODS, FACCC, administrative director of cancer services and ambulatory infusion at Southern Ohio Medical Center, about care coordination strategies and lessons learned from her team's experience administering biomarker testing. Finally, Kristina A. Matkowskyj, MD, PhD, pathologist at Mayo Clinic, explains the vital role of pathologists in identifying biomarkers and strategies for success in biopsies. "We have to work closely with our pathology colleagues to make sure that all of the tests are done quickly and so that they are readily available by the time the patient is seen in clinic." - Nataliya Uboha, MD, PhD "Tracking, knowing what and when new things come out, being able to mine your data to find those things, I think is going to be uber critical." - Wendi Waugh, BS, RT(R)(T), CMD, ODS, FACCC "I believe that the precision medicine testing that we're doing today... is going to change the face of cancer care." - Wendi Waugh, BS, RT(R)(T), CMD, ODS, FACCC "As a pathologist, if I was able to stress one thing, it would be to collect as many biopsies as is safely possible for that particular patient." - Kristina A. Matkowskyj, MD, PhD Guests: Nataliya Uboha, MD, PhD Medical Oncology University of Wisconsin Health Madison, WI Wendi Waugh, BS, RT(R)(T), CMD, ODS, FACCC Administrative Director of Cancer Services & Ambulatory Infusion Southern Ohio Medical Center Portsmouth, OH Kristina A. Matkowskyj, MD, PhD Pathologist Mayo Clinic Rochester, MN
Stress/Stille-thuisdrinker/Bingedrinker/Perfectionist/Erfelijk/ Burn-out/ Gastric bypass/Of...Check!We grijpen steeds meer naar de fles. Wat zijn jouw triggers en waar ligt de problematische grens? Is de stap naar hulp te groot of net een duwtje nodig, luister dan naar dit “STOPcast” programma. Met een vleugje humor neemt Evi Heyndrickx je mee in haar ontwapenend verhaal. Ludiek gaat ze in dialoog met getuigen, specialisten om dé methodiek te vinden om jouw foute patronen te doorbreken. Soms praat ze tegen zichzelf (herkenbaar?), vanaf nu kan je stiekem meeluisteren.
Get Your SUPER-SUPPLIMENTS HERE: https://vni.life/wam Use Code WAM15 & Save 15%! Life changing formulas you can't find anywhere else! DITCH YOUR DOCTOR! https://www.livelongerformula.com/wam Get a natural health practitioner and work with Christian Yordanov! Mention WAM and get a FREE masterclass! You will ALSO get a FREE metabolic function assessment! GET YOUR APRICOT SEEDS at the life-saving Richardson Nutritional Center HERE: https://rncstore.com/r?id=bg8qc1 Use code JOSH to save money! GET YOUR WAV WATCH HERE: https://buy.wavwatch.com/WAM Use Code WAM to save $100 and purchase amazing healing frequency technology! Josh Sigurdson reports on a new study out of South Korea confirming that both the mRNA and non-mRNA "Covid" vaccines caused a massive heightened risk of 6 cancers after studying the vaccinated for 2 years. The study looks at 3 main groups. The unvaccinated, the vaccinated and the vaccinated and boosted. The results show the following: Overall cancer risk increased 27%. Breast cancer, 20%. Colorectal cancer, 28%. Gastric cancer, 34%. Lung cancer, 53%. Prostate cancer, 69%. Thyroid cancer, 35%. Now, this is one of many studies that have proven these injections cause cancer. In fact, many studies have far higher numbers. Moderna admitted in front of a House hearing that their mRNA vaccines caused cancer. Pfizer which just got $70 billion from President Trump knowingly hid evidence that their vaccines caused cancer in children which they attempted to cover-up before being uncovered in court. Croatian pathologist Ivana Pavic claims that 65% of cancer cases recieved one or more covid injections. This it a bio war crime. It's not just the vaccines! From cell towers to fluoride, from pesticides forming poison clouds over populations to stratospheric aerosol geoengineering. Let's not forget mRNA meat and Moderna's push to spray mRNA pesticides on our fruits and vegetables. We are all under attack. There are many natural treatments and preventatives like apricot seeds (laetrile) as well as CBD-A. The question is, will people take preventatives seriously or wait until they're sick which we hope doesn't happen to any of you. Stay tuned for more from WAM! HELP SUPPORT US AS WE DOCUMENT HISTORY HERE: https://gogetfunding.com/help-keep-wam-alive/# GET HEIRLOOM SEEDS & NON GMO SURVIVAL FOOD HERE: https://heavensharvest.com/ USE Code WAM to save 5% plus free shipping! BUY GOLD HERE: https://firstnationalbullion.com/schedule-consult/ FIND OUR CoinTree page here: https://cointr.ee/joshsigurdson PURCHASE MERECHANDISE HERE: https://world-alternative-media.creator-spring.com/ PayPal: ancientwonderstelevision@gmail.com JOIN US on SubscribeStar here: https://www.subscribestar.com/world-alternative-media For subscriber only content! Pledge here! Just a dollar a month can help us alive! https://www.patreon.com/user?u=2652072&ty=h&u=2652072 BITCOIN ADDRESS: 18d1WEnYYhBRgZVbeyLr6UfiJhrQygcgNU World Alternative Media 2025
Gastric ultrasound can be so important in assessing aspiration risk in any number of patients preoperatively, and POCUS can be an incredibly valuable tool in this circumstance. In this episode of RAPM Focus, RAPM social media editor, Alopi Patel, MD, converses with Jacob Wrobel, MD, and Alexander Doyal, MD, MPH, FASA, following the June 2025 publication of “Developing a method for ultrasound estimation of gastric volume in patients with previous gastric sleeve.” Dr. Jacob Wrobel is a recent graduate of the University of North Carolina School of Medicine and is preparing to begin his anesthesiology residency at the University of Pittsburgh Medical Center. He has a special interest in the applications for point-of-care ultrasound in the perioperative setting and plans to continue to pursue research in this area in his career as an anesthesiologist. Dr. Alexander Doyal is an associate professor in the department of anesthesiology within the transplant and vascular anesthesia division at the University of North Carolina. He has a keen interest in POCUS, research, and education. He serves as the POCUS course director in the School of Medicine. He also leads workshops for residents, and teaches and mentors faculty at regional and national meetings. His research interests are varied, and included novel POCUS clinical applications. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.
Are you aware that programmed cell death-ligand 1 (PD-L1) testing may not be needed to guide immunotherapy decisions in resectable gastric/gastroesophageal junction (GEJ) cancers? Credit available for this activity expires: 9/22/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002919?ecd=bdc_podcast_libsyn_mscpedu
In this bite-sized episode of SurgOnc Today, Drs. Zhi Ven Fong and Adriana Gamboa discuss palliative techniques for the management of gastric outlet obstruction in pancreatic cancer. Stay tuned for Part 2!
Maximizing Fitness, Fat Loss & Running Through Perimenopause
Often, the very thing we love, running and endurance training, is silently adding counterproductive stress to our body. While not a sole causative factor in adverse health outcomes, recent research findings have scientists, practitioners, recreational endurance athletes, and runners pausing across the world!In this episode of Maximizing Hormones, Physique, and Running Through Perimenopause, Louise, one of the world's leading integrative health practitioners, exercise physiologist, and fitness experts explores the often-overlooked connection between female physiology, gut health, and endurance training.Drawing on her 22+ years of clinical experience, research, supporting thousands of active individuals at all levels, and her own journey as a dedicated runner reversing stomach precancer, Louise explains how stress, gut health, and hormonal changes intersect during perimenopause and what you can do about it. From the science behind intestinal permeability (that stubborn lower ab “pooch” and bloat) to targeted, affordable supplements and practical fueling strategies, she keeps it simple, science-based, and specific to highly active women who love to run.You'll also hear Louise's candid take on the latest viral headlines and misleading social media spins claiming running causes cancer, why it's not that simple, and how to critically approach the noise without giving up the sport you love. This episode is equal parts honesty, science, and actionable tools so you can run, live, and thrive with confidence.If ready to critically think about novel research findings, instead of panic or jump to conclusions, this episode is for you!Feel, look & perform your best with my “All About Gut Health & How to Restore It” Mini Course here: https://www.breakingthroughwellness.com/offers/tKTJYVjP/checkout Link to check out the “Healthy Gut Support” (intestinal support formula) mentioned in the beginning of this episode: https://equi.life?irad=859795&irmp=3644194Watch my blog article “The Art of Magaining Stress & Chronic Disease Risk When You Love Fitness or Running… A Lot” “https://www.breakingthroughwellness.com/blog/dedicated-female-runners-the-art-of-managing-stress-women-s-health-osteoporosis-chronic-disease-riskLearn & level up with my free nutrition guide and award-winning Badass Breakthrough Academy to thrive through perimenopause with less stress: https://www.breakingthroughwellness.com/ Link to our FullScript where you can see our curated best supplement picks & save 20% off, including 20% off Seed, the supplement mentioned in today's episode: https://us.fullscript.com/welcome/breakingthroughwellness/store-startTake advantage of our podcast listener discount and save 20% off all of Kion's science-backed clean products: https://www.getkion.com/paTune in weekly to "Maximizing Hormones, Physique, and Running Through Perimenopause" for our simple female-specific science-based revolution. Let's unlock our best with less stress!I'd love to connect!Instagram
In this encore episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori 2. H. pylori Overview- Gram-negative bacterium, can colonize the stomach lining- Many individuals remain asymptomatic- Symptoms - Can contribute to gastritis and peptic ulcers- Produces urease, hydrolyzes urea into ammonia (NH₃) andcarbon dioxide (CO₂)- Ammonia neutralizes stomach acid locally, protective microenvironment- H. pylori damages the mucosal barrier and contributes to persistence- Possesses additional virulence factors 3. Gastric Anatomy - Stomach is divided into the cardia, fundus, body, and pylorus- The gastric mucosa - The epithelial lining; mucous cells, parietal cells, chief cells, and more 4. Mucous Cells and Mucosal Protection - Line the gastric pits and secrete thick, viscous mucus- Mucus composed of water, mucin glycoproteins, and other low-molecular-weight molecules- Traps bicarbonate ions (HCO₃⁻)- Shields the stomach lining 5. Parietal Cells - Located in the gastric glands, predominantly in the fundus and body- Secrete hydrochloric acid (HCl)- Secrete intrinsic factor (IF) 6. Vitamin B12 Overview - Cobalamin: DNA synthesis, red blood cell formation, neurological function, methylation, and more- Methylcobalamin and 5-deoxyadenosylcobalamin- Non-active forms include hydroxocobalamin and synthetic cyanocobalamin 7. Vitamin B12 Absorption Pathway - B12 is released from proteins by HCl and pepsin- Binds first to haptocorrin- In the small intestine, pancreatic enzymes degrade haptocorrin- B12 binds intrinsic factor - Absorption in the ileum - Impairment 8. Chief Cells - Located in the gastric glands- Secrete pepsinogen, activated by acid into pepsin- Also secrete gastric lipase 9. Hydrochloric Acid (HCl) - Secreted by parietal cells- Denatures dietary proteins and activates pepsinogen- Acts as a defense mechanism by aiding in sterilizing ingested food 10. Relevance of H. pylori - Produces urease that breaks down urea into NH₃ and CO₂- Ammonia neutralizes acid locally, forming a protective “bubble”- Enhances mucosal damage and microbial persistence 11. B12 Absorption - Multiple factors and root causes can impair absorption- H. pylori 12. Hypochlorhydria - Symptoms- Absorption: vitamin B12, iron, calcium, magnesium, more- Small Intestinal Bacterial Overgrowth (SIBO) 13. Conclusion- Multi-factorial, root cause approachThank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Today on the Inside Word! Manu through a Manatee(10:00) - NFR Flyaway(16:00) - A kind message about becoming Sniper Elite(21:00) - Jay's house update(29:00) - Jay's health update(31:00) - Note on a car (34:00 - Gastric bypass (36:00) - Creating a fake ID for your own son Want to get in touch? Hit us up, here: https://linktr.ee/notforradioBecome a Sniper Elite: https://plus.rova.nz/ Learn more about your ad choices. Visit megaphone.fm/adchoices
In this encore episode, we detail overlap among intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO - Discussion of overlap 2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea - Methane and intestinal transit- Bloating, abdominal discomfort, constipation - Associated with irritable bowel syndrome with constipation (IBS-C) 3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating - Different forms of SIBO can coexist 6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea 7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions - Gastric acid, digestion and antimicrobial defense 9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release 10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation 11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption 12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility - Intestinal motility and ENS function in microbial homeostasis - Hydrogen sulfide as a gasotransmitterGet Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Today on the podcast. 2 - Glue on the nether region.10 - When do you wash your hands? 15 - Gastric bypass surgery.25- 100% New Zealand Bacon and Ham Awards.45 - Original Rolls-Royce crank.46 - Working at a crematorium. New NFR sunglasses - https://neufound.com/pages/notforradio Give us a follow if you haven't already ~ Jay and Dunc. Want to get in touch? Hit us up, here: https://linktr.ee/notforradio Become a Sniper Elite: https://plus.rova.nz/ Support the show: https://plus.rova.nz/ Learn more about your ad choices. Visit megaphone.fm/adchoices
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
Is it time to rethink perioperative immunotherapy in resectable gastric and gastroesophageal junction (GEJ) cancers? See the latest data and expert takeaways. Credit available for this activity expires: 7/18/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002710?ecd=bdc_podcast_libsyn_mscpedu
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GUA865. CME/MOC/AAPA/IPCE credit will be available until July 16, 2026.Achieving Excellence in Gastric/GEJ Cancer Care: Multidisciplinary Guidance on Immunotherapy Platforms in Resectable Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca.Disclosure information is available at the beginning of the video presentation.
In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in conditions such as small intestinal bacterial overgrowth (SIBO).Topics:1. Hypochlorhydria - Low stomach acid.- Aging, autoimmune gastritis, chronic PPI use, H. pylori infection.2. H. pylori - Common gram-negative bacterium that colonizes the stomach lining.- Symptoms.- Produces urease.- Ammonia neutralizes acid, creating a protective microenvironment.- Additional virulence factors and ability to form biofilms contribute to persistence.3. Gastric Anatomy & Layers- The stomach: hollow, muscular organ for mechanical and chemical digestion.- Regions: Cardia, fundus, body, and pylorus.- Layers: Mucosa, Submucosa, Muscularis externa, Serosa4. Mucosal Layer - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.- Gastric pits lead to gastric glands, which contain specialized secretory cells.5. Specialized Gastric Cells- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.- Intrinsic factor and vitamin B12 absorption.6. Vitamin B12 Absorption- Essential for DNA synthesis, RBC formation, neurological function.- Released from food proteins by gastric acid and pepsin.- Impaired absorption.7. Role of Gastric Acid in Broader Micronutrient Absorption- Absorption of minerals.- Soluble, ionized state.- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.8. Protective Role of Gastric Acid- Acts as a line of defense against ingested pathogens.- Maintains low microbial diversity in the stomach.- Low HCl and SIBO (Small Intestinal Bacterial Overgrowth).9. Symptoms of Low Stomach Acid- Bloating, early satiety, excessive belching.- Undigested food in stool, chronic constipation.- May reflect impaired enzymatic activation and digestive insufficiency.10. Conclusion- Multifactorial causes and downstream effects.- Optimal range of stomach acid: neither high nor low.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Did you know that immunotherapy has shown promise in the perioperative setting for gastric and gastroesophageal junction (GEJ) adenocarcinoma? Credit available for this activity expires: 7/11/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/transforming-gastric-and-gej-cancer-care-perioperative-2025a1000i7e?ecd=bdc_podcast_libsyn_mscpedu
Could the latest data in novel antibody-drug conjugates reshape your treatment approach for patients with gastric cancer? Credit available for this activity expires: 7/1/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002638?ecd=bdc_podcast_libsyn_mscpedu
Until now there has been no approved treatment for malaria in newborns and infants weighing less than 4.5kg. We hear from families and clinicians firsthand what this new formulation, due to be approved across eight African countries, means for them.We are joined by Professor Damian Bailey as we become pickle juice detectives to find out why it is becoming more common for athletes to drink the briny solution in a bid to tackle cramps.Gastric cancer is the fifth leading cause of cancer-related deaths worldwide, researchers from the International Agency for Research on Cancer have predicted that the bacteria Helicobacter pylori may be responsible for over 11 million future gastric cancer cases in people born between 2008 and 2017. How can we prepare for a future where socially assistive robots are integrated into healthcare and the home? Professor Helen Meese joins us to explain some of the practical and ethical concerns that accompany the rise of helpful robots in clinical and home settings.Presenter: Claudia Hammond Producer: Katie Tomsett Studio Managers: Searle Whittney & Duncan Hannant
Gastric sleeve surgery is the key feature of a pair of recent cases from the journal, which start this episode (1:17). Both cases feature 25-yo women with presentations in common: paraesthesia and limb weakness, along with disordered eye movement. Their symptoms arose soon after the gastrectomy operation. https://pn.bmj.com/content/25/3/268 The second report is a "true grey case" (22:14), with a myriad of presenting symptoms in a 27-yo man: fevers, weight loss, lethargy, light sensitivity, and skin plaques around the nose and mouth. Steroid treatment was started with a suspicion of a connective tissue disease, but was halted when his condition soon worsened. Some feathered friends of the podcast shine a light on the diagnosis. https://pn.bmj.com/content/25/3/253 The case reports discussion is hosted by Prof. Martin Turner¹, who is joined by Dr. Ruth Wood² and Dr. Babak Soleimani³ for a group examination of the features of each presentation, followed by a step-by-step walkthrough of how the diagnosis was made. These case reports and many others can be found in the June 2025 issue of the journal. (1) Professor of Clinical Neurology and Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, and Consultant Neurologist at John Radcliffe Hospital. (2) Neurology Registrar, University Hospitals Sussex. (3) Clinical Research Fellow, Oxford Laboratory for Neuroimmunology and Immunopsychiatry, Nuffield Department of Medicine, University of Oxford Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production by Amy Ross Russell and Brian O'Toole, editing by Brian O'Toole. Thank you for listening.
“I couldn't even walk around the block.” That's what Frank said before he had gastric sleeve surgery.Now? He's down over 100 pounds, mentally stronger than ever, and finally reclaiming his life.
Driveway Beers PodcastBig Health News!!Big health news from Mike! The fellas talk about how Mike's surgery went for his gastric sleeve. Only 5 days after the surgery, Mike sits down and talks about the entire experience. The guys share their numbers from the beginning to today which is well over a year from when they started. Come see if Alex can make Mike laugh and bust open his stitches!! #gastric #sleeve #weight #loss #podcast #health Please subscribe and rate this podcast on your podcast platforms like Apple and Spotify as it helps us a ton. Also like, comment, subscribe and share the video on Youtube. It really helps us get the show out to more people. We hope you enjoyed your time with us and we look forward to seeing you next time. Please visit us at https://drivewaybeerspodcast.com/donate/ to join The Driveway Club and buy us a bourbon! Buy us a bottle and we'll review it on a show!Leave us a comment and join the conversation on our discord at https://discord.gg/rN25SbjUSZ.Please visit our sponsors:Adam Chubbuck of Team Alpha Charlie Real Estate, 8221 Ritchie Hwy, Pasadena, MD 21122, www.tacmd.com, (443) 457-9524. If you want a real estate agent that will treat your money like it's his own and provide you the best service as a buyer or seller, contact Adam at Team Alpha Charlie.If you want to sponsor the show, contact us at contact@drivewaybeerspodcast.comCheck out all our links here https://linktr.ee/drivewaybeerspodcast.comIf you're looking for sports betting picks, go to conncretelocks.com or send a message to Jeremy Conn at Jconn22@gmail.comFacebook Page https://www.facebook.com/drivewaybeerspodcast/#podcast #whiskey #bourbon
In this encore episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO - Discussion of overlap 2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea - Methane and intestinal transit- Bloating, abdominal discomfort, constipation - Associated with irritable bowel syndrome with constipation (IBS-C) 3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating - Different forms of SIBO can coexist 6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea 7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions - Gastric acid, digestion and antimicrobial defense 9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release 10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation 11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption 12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility - Intestinal motility and ENS function in microbial homeostasis - Hydrogen sulfide as a gasotransmitterGet Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Critical Care St James's Hospital in the past year, have abolished the practice of measuring Gastric Residual Volumes (GRV's). This practice has been ingrained in many ICU's nationally and internationally for many years now despite little to no evidence to support it. We interview key members of the MDT today including Dr Arnaud-Felix Miailhe Consultant Intensivist, Emer O Sullivan Clinical Specialist Dietitian and Deirdre Doyle Practice Development Facilitator Critical Care St James's Hospital about the changes in practice, the literature surrounding this practice and the value of MDT involvement in driving change.
In this episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's survival mechanisms in the acidic gastric environment as well as potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori 2. H. pylori Overview- Gram-negative bacterium, can colonize the stomach lining- Many individuals remain asymptomatic- Symptoms - Can contribute to gastritis and peptic ulcers- Produces urease, hydrolyzes urea into ammonia (NH₃) andcarbon dioxide (CO₂)- Ammonia neutralizes stomach acid locally, protective microenvironment- H. pylori damages the mucosal barrier and contributes to persistence- Possesses additional virulence factors 3. Gastric Anatomy - Stomach is divided into the cardia, fundus, body, and pylorus- The gastric mucosa - The epithelial lining; mucous cells, parietal cells, chief cells, and more 4. Mucous Cells and Mucosal Protection - Line the gastric pits and secrete thick, viscous mucus- Mucus composed of water, mucin glycoproteins, and other low-molecular-weight molecules- Traps bicarbonate ions (HCO₃⁻)- Shields the stomach lining 5. Parietal Cells - Located in the gastric glands, predominantly in the fundus and body- Secrete hydrochloric acid (HCl)- Secrete intrinsic factor (IF) 6. Vitamin B12 Overview - Cobalamin: DNA synthesis, red blood cell formation, neurological function, methylation, and more- Methylcobalamin and 5-deoxyadenosylcobalamin- Non-active forms include hydroxocobalamin and synthetic cyanocobalamin 7. Vitamin B12 Absorption Pathway - B12 is released from proteins by HCl and pepsin- Binds first to haptocorrin- In the small intestine, pancreatic enzymes degrade haptocorrin- B12 binds intrinsic factor - Absorption in the ileum - Impairment 8. Chief Cells - Located in the gastric glands- Secrete pepsinogen, activated by acid into pepsin- Also secrete gastric lipase 9. Hydrochloric Acid (HCl) - Secreted by parietal cells- Denatures dietary proteins and activates pepsinogen- Acts as a defense mechanism by aiding in sterilizing ingested food 10. Relevance of H. pylori - Produces urease that breaks down urea into NH₃ and CO₂- Ammonia neutralizes acid locally, forming a protective “bubble”- Enhances mucosal damage and microbial persistence 11. B12 Absorption - Multiple factors and root causes can impair absorption- H. pylori 12. Hypochlorhydria - Symptoms- Absorption: vitamin B12, iron, calcium, magnesium, more- Small Intestinal Bacterial Overgrowth (SIBO) 13. Conclusion- Multi-factorial, root cause approachThanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Why is your sport horse not performing at its best? In this insightful round table discussion, Dr. Mike Pownall and the veterinary team at McKee-Pownall break down the multi-layered causes of poor performance in equine athletes. From subtle lameness and dental pain to ulcers and metabolic disease, this episode explores the interconnected systems that influence your horse's health and rideability.Joined by Drs. Esther Millares, Natalie Sanza, and Katelyn McNicol—with lead vet assistant Karen Foell—this episode emphasizes the importance of early detection, diagnostic precision, and a collaborative care approach. Whether you're a competitive rider, trainer, or passionate owner, this episode will change the way you think about what's really going on when your horse feels “off.”Timestamps00:00 – Welcome to the EquiConnect Podcast01:20 – Why poor performance isn't just lameness03:00 – Most common causes of lameness in sport horses05:20 – When it's not the limbs: other sources of poor performance07:00 – Dental health: the missing link in equine performance09:15 – Signs of dental pain and behavioural clues11:00 – How often should your horse's teeth be checked?12:30 – Bit-related injuries and overlooked oral discomfort13:00 – Gastric ulcers: pain, behavior, and underperformance15:00 – Why diagnosis matters before treatment17:30 – Preventing ulcers through diet, stress reduction, and training plans20:00 – Understanding metabolic disease: EMS and Cushing's23:30 – Preventing laminitis and managing metabolic horses25:00 – Myths that delay proper care27:00 – Supplements, shoeing, and the importance of diagnostics30:00 – New tools: regenerative therapies and smarter supplements32:00 – The power of teamwork: vet, farrier, body worker, nutritionist33:00 – Final thoughts and takeawaysQuotes“Believing a stiff horse is just naughty is like blaming your car for being slow when the tires are flat.” – Dr. Esther Millares“Dental pain can be constant and invisible—but it affects everything from eating to contact under saddle.” – Dr. Katelyn McNichol“Gastric ulcers don't just hurt—they change your horse's entire mindset.” – Dr. Natalie Sanza“Education and empathy—not judgment—are how we improve sport horse care.” – Dr. EstherMillares“Diagnosis isn't just a step—it's the foundation for treatment that works.” – Dr. Natalie SanzaKey Takeaways & ResourcesDiagnosing Poor PerformancePoor performance is rarely caused by a single issue. Often, subtle lameness, gastric discomfort, dental problems, and metabolic disorders overlap.Know your horse's “normal.” Behavioural changes are often the first clue.Dental HealthSubtle dental pain may show up as training resistance, chewing abnormalities, or changes in body condition.Annual dental exams are essential; some horses benefit from 6–9 month intervals.Gastric UlcersUlcers cause both physical and behavioural symptoms and are common in sport horses.Gastroscopy is the gold standard for diagnosis and should guide tailored treatment plans.Management includes low-stress environments, frequent hay access, and limited high-intensity work.Metabolic ConditionsEquine Metabolic Syndrome (EMS) and Cushing's Disease (PPID) can impact energy, recovery, and condition.Laminitis prevention starts with early diagnosis, diet changes, and consistent exercise.Advanced TherapiesTools like stem cell therapy, PRP, and IRAP are extending equine careers and targeting healing.Collaborative...
PAIN – How to tell if your horse has kissing spine, gastric ulcers of arthritisHow do you know if your horse is in pain, and more importantly, where that pain is coming from?In this episode, equine physiotherapist Dr Gillian Tabor explores the complexities of recognising pain in horses. From facial expressions and behaviour to the blurred lines between conditions like kissing spines, gastric ulcers and lameness, Gillian dives into the latest research to help you spot the subtle (and not-so-subtle) signs that something isn't right.Whether you're a horse owner, rider or equine professional, this episode is packed with insights on how horses show pain, why behaviours shouldn't be dismissed as 'naughty', and why thinking pain first could be the most important step in safeguarding your horse's welfare.Topics include:The science of how horses perceive painAnticipatory vs actual pain behavioursOverlapping symptoms across common equine conditionsWhy girthiness isn't always about the girthKey research from Dalla Costa, Dyson, Kumar and more----To find out more about becoming a member >>> AskAnimalweb.comNot a Member? Join for as little as £6 a month or £8 on a month-by-month basis to access all the test results and have a say in what we test and investigate next. For this, you also get access to all past and future webinars, videos, podcasts, and articles, the opportunity to take part in testing and research and SOOOO much more. Hosted on Acast. See acast.com/privacy for more information.
How can a quick bedside ultrasound transform patient safety in anesthesia? Today, Sharon and guest co-host Carole Doyscher, CRNA, BSN, MS, APRN explore the growing role of gastric point-of-care ultrasound (PoCUS), a tool helping anesthesia providers assess stomach contents in real time. Joined by Rachel Edgerton, DNAP, MSNA, CRNA, APRN, CHSE and three doctoral students from St. Mary's University - Molly O'Neill, BSN, RN, Hannah Peine, BSN, RN, CCRN, CMC, Alyssa Klein, BSN, RN - the episode dives into their groundbreaking DNP project educating CRNAs on this skill. Here's some of what we discuss in this episode:
In this podcast Dr. Noah Cohen and Dr. Brett Ecker review the current state and future directions of the management of gastric carcinomatosis with international gastric carcinomatosis expert Dr. Maheswari Senthil.
In this episode of the EquiConnect Podcast, Dr. Mike Pownall and co-host Karen Foell dive into the crucial topic of Equine Gastric Ulcer Syndrome (EGUS) with veterinarians Dr. Rafael Gomez and Dr. Natalie Sanza. They explore the different types of ulcers, common causes, and cutting-edge treatment approaches. Listeners will gain valuable insights into diagnosing and managing this prevalent condition in horses, as well as key strategies for prevention. Plus, get an exclusive look at the upcoming Gastroscopy Open House Event—a must-attend opportunity for horse owners to see gastroscopy in action. Whether you're a competitive rider, trainer, or dedicated horse owner, this episode is packed with expert knowledge to help keep your horse healthy and happy.Timestamps: [00:00:00] – Introduction to the EquiConnect Podcast and episode overview [00:01:00] – Meet the experts: Dr. Rafael Gomez & Dr. Natalie Senza [00:02:00] – What is Equine Gastric Ulcer Syndrome (EGUS)?[00:03:00] – The two types of gastric ulcers: Squamous vs. Glandular[00:04:30] – Causes of equine ulcers: Feeding, stress, and more[00:08:00] – How feeding schedules affect ulcer development[00:09:30] – Stress and its impact on gastric health[00:11:00] – Shocking statistics: How common are gastric ulcers?[00:14:00] – Diagnosing ulcers: Why gastroscopy is the gold standard[00:17:00] – Recognizing symptoms: Poor performance, weight loss, and more[00:19:00] – The role of treatment: Omeprazole, GastroGard, and other medications[00:25:00] – Preventing ulcers: The power of management & nutrition[00:31:00] – Three pillars of ulcer prevention: Management, supplements, and medication[00:34:00] – Post-treatment care: How to prevent relapse[00:36:00] – Exciting event: Gastroscopy Open House on March 22nd[00:40:00] – Final thoughts & key takeawaysNotable Quotes:“More than half of the horse population suffers from ulcers—whether they're in the wild or in competition.” – Dr. Rafael Gomez “The only way to diagnose ulcers with certainty is through gastroscopy—there is no magic test from the outside.” – Dr. Natalie Sanza “If we don't change management after treatment, ulcers can return in as little as two days.” – Dr. Rafael Gomez “Management is the best medicine. The right feeding schedule, turnout, and stress reduction are key.” – Dr. Natalie SanzaResources & Mentioned Topics:
In this episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO - Discussion of overlap 2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea - Methane and intestinal transit- Bloating, abdominal discomfort, constipation - Associated with irritable bowel syndrome with constipation (IBS-C) 3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating - Different forms of SIBO can coexist 6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea 7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions - Gastric acid, digestion and antimicrobial defense 9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release 10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation 11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption 12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility - Intestinal motility and ENS function in microbial homeostasis - Hydrogen sulfide as a gasotransmitterThank you to our episode sponsors:1. Shop Fresh Press Farms'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Shop CYLN's full skincare line here.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
In this episode of the Becker's Healthcare Podcast, host Lukas Voss explores cutting-edge advancements in gastric and esophageal cancer care with two leading experts from City of Hope. Surgical Oncologist Dr. Yanghee Woo and Medical Oncologist Dr. Dani Castillo discuss the benefits of a multidisciplinary approach, the impact of robotic-assisted minimally invasive surgery, and the latest clinical trials offering new hope for patients.This episode is sponsored by City of Hope.
Gut Check: Hypermobility and Gastric Disorders with Dr Dacre Knight by Gastroenterology Learning Network
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