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The way we describe what it is we do...who it is we help...and how? Is crucially important when it comes to our people finding us and hiring us. But the dark side to this mentality is that it also often leads to sticking ourselves in the box that appears “desirable” on the surface...meanwhile pushing pieces of ourselves away that actually have the power to help us stand out. In today's episode you'll be challenged to think about your role as a “coach” through an entirely new perspective.Here are a few ways we can keep this party going
You want to change careers but you're feeling stuck and don't quite know who or what is stopping you. Feeling stuck is incredibly frustrating, however there are some proactive things that you can do to regain control of your career and kick-start your career progression especially when you realize you have more control over the situation than you thought. ---------------------------------------------------------- Register for my FREE monthly 5 Day Program - Change your Career Without the Financial Fear - Designed to help women to start living the life they want without changing who they are or how much money they have in the bank. https://janicesutherland.ck.page/careernofear ____________________________________ FIND ME ON: Official Website | https://www.janicesutherland.com Facebook | https://www.facebook.com/iamjanicesutherland LinkedIn | https://www.linkedin.com/in/iamjanicesutherland Twitter | https://www.twitter.com/This_Woman_Can Janice Sutherland helps frustrated, mid-career, professional women of color re-align their careers while staying true to their values and personal and professional priorities. #thiswomancan #careertransition
This month on Episode 30 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the October 29 and November 12 issues of Circulation Research. This episode also features a conversation with Dr Elisa Klein from the University of Maryland about her study, Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity. Article highlights: Subramani, et al. CMA of eNOS in Ischemia-Reperfusion Liu, et al. Macrophage MST1 Regulates Cardiac Repair Van Beusecum, et al. GAS6/Axl Signaling in Hypertension Pati, et al. Exosomes Promote Efferocytosis and Cardiac Repair Cindy St. Hilaire: Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh and today I'll be highlighting articles presented in our October 29th and November 12th issues of Circulation Research. I also will speak with Dr Elisa Klein from the University of Maryland about her study, Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity. Cindy St. Hilaire: The first article I want to share is titled, Chaperone-Mediated Autophagy of eNOS in Myocardial Ischemia Reperfusion Injury. The first author is Jaganathan Subramani and the corresponding author is Kumuda Das from Texas Tech University Health Sciences Center. Reestablishing blood flow to ischemic heart muscle after myocardial infarction is critical for restoring muscle function but the return of flow itself can cause damage, a so-called reperfusion injury. The generation of reactive oxygen species or ROS and loss of nitric oxide or NO both contribute to reperfusion injury. Reperfusion injury is exacerbated when the NO producing enzyme, endothelial nitric oxide synthase or eNOS, produces damaging super oxide anions instead of NO. This switch in eNOS function is caused by glutathionylation of the enzyme, termed SG-eNOS. But how long this modification lasts and how it is fixed is unclear. This group used an in vitro model of ischemia reperfusion where human endothelial cells are exposed to several hours of hypoxia followed by reoxygenation. In this model, they found the level of SG-eNOS steadily increases for 16 hours and then sharply decreases. By blocking several different cellular degradation pathways, they discovered that this decrease in S-G eNOS was due to chaperone mediated autophagy with the chaperone protein, HSC70, being responsible for SG-eNOS destruction. Importantly, this team went on to show that pharmacological D-glutathionylation of eNOS in mice promoted NO production and reduced reperfusion injury, suggesting this approach may be of clinical benefit after myocardial infarction. Cindy St. Hilaire: The second article I want to share is titled Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4. The first author is Mingming Liu and the corresponding author is Ding Ai and they're from Tianjin Medical University. Myocardial infarction injures the heart muscle. These cells are unable to regenerate and instead a non-contractile scar forms and that fibrotic scar can lead to heart failure. Cardiomyocytes specific inhibition of the kinase MST1 can prevent infarction induced death of the cells and preserve the heart function, suggesting that it may have clinical utility. However, MST1 also has anti-inflammatory properties in macrophages. So inhibition of MST1 in macrophages may delay inflammation resolution after MI and impair proper healing. Thus, targeting this enzyme for therapy is not a straightforward process. This study examined mice lacking MST1 in macrophages and found that after myocardial infarction, the inflammatory mediator leukotriene B4 was upregulated in macrophages and the animal's heart function was reduced compared to that of wild type controls. Blocking the action of leukotriene B4 in mice reduced infarction injuries in the hearts of MST1-lacking animals and enhanced repair in the injured hearts of wild type animals given an MST1 inhibitor. The results suggest that if MST1 inhibition is used as a future post infarction regenerative therapy, then leukotriene B4 blockade may prevent its inflammatory side effects. Cindy St. Hilaire: The next article I want to share is titled Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension. The first author is Justin Beusecum and the corresponding author is David Harrison and they're from Vanderbilt University. Inflammation contributes to hypertension pathology but the links of this relationship are unclear. It's thought one trigger of inflammation may be the hypertension-induced mechanical stretch of vascular endothelial cells. Mechanical stretch causes endothelial cells to release factors that convert circulating monocytes into inflammatory cells. And one such factor is the recently identified Axl and Siglec-6 positive dendritic cells, also called AS DCs. AS DCs produce a large amount of inflammatory cytokines but little is known about the role of AS DCs or their cytokines in hypertension. This group found elevated levels of AS DCs in hypertensive people compared to normal tensive individuals. Mechanical stretch of human endothelial cells promoted the release of GAS6, which is an activator of the AS DC cell surface kinase, Axl. This stretch induced GAS6 release also promoted conversion of co-cultured monocytes to AS DCs. Inhibition of GAS6 or Axl in the co-cultured system prevented conversion of monocytes to AS DCs. This team went on to show that hypertensive humans and mice have elevated levels of plasma GAS6 and that blocking Axl activity in mice attenuated experimentally induced hypertension and the associated inflammation. This work highlights a new signaling pathway, driving hypertension associated inflammation and identifies possible targets to treat it. Cindy St. Hilaire: The last article I want to share is titled Novel Mechanisms of Exosome- Mediated Phagocytosis of Dead Cells in Injured Heart. The first author is Mallikarjun Patil and Sherin Saheera and the corresponding author is Prasanna Krishnamurthy from the University of Alabama, Birmingham. After myocardial infarction inflammation must quickly be attenuated to avoid excessive scarring and loss of muscle function. Macrophage mediated efferocytosis of dead cells is a critical part of this so-called inflammation resolution process. And resolution depends in part on the protein. MFGE8. MFGE8 helps macrophages engage with eat me signals on the dead cells and loss of macrophage MFGE8 delays inflammation resolution in mice. Because stem cell-derived exosomes promote cardiac repair after infarction and are anti-inflammatory and express MFGE8, this group hypothesized that perhaps part of a stem-cell derived exosomes proresolven activity may be due to boosting macrophage efferocytosis. They showed that stem cell derived exosomes did indeed boost efferocytosis of apoptotic cardiomyocytes in vitro and in vivo. An in vitro experiments showed that if exosomes lacked MFGE8 then efferocytosis by macrophages was reduced. Furthermore, after myocardial infarction in mice, treatment with MFGE8 deficient exosomes did not reduce infarct size and did not improve heart function compared to control exosomes. These results suggest MFGE8 is important for the cardioprotective effects of stem cell-derived exosomes. And that this protein may be of interest for boosting efferocytosis after myocardial infarction and in other pathologies where inflammation is not readily resolved. Cindy St. Hilaire So today, Dr Elisa Klein from the Department of Biomedical Engineering at the University of Maryland is with me to discuss her study Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity and this article is in our November 12th issue of Circulation Research. So Dr Klein, thank you so much for joining me today. Elisa Klein: Thank you for having me. Cindy St. Hilaire: Yeah. So broadly your study is investigating how blood flow patterns specifically, kind of, laminar and oscillatory flow, how those blood flow patterns impact protein modifications and activity. So before we, kind of, get to the details of the paper, I was wondering if you could just introduce for us the concept of blood flow patterns, how they change in the body naturally but then how they might influence or contribute to disease pathogenesis in the vessels? Elisa Klein: Sure. So obviously we have blood flow through all of our vessels and since we are complex human beings, we have complex vascular beds that turn and that split or bifurcate. And so every place we get one of these bifurcations or a turn in a vessel, the blood flow can't quite make that turn or split perfectly. So you get a little area where the flow is a oscillatory or what we call disturbed. There's lots of different kinds of disturbed flow. And the reason why that's important is because you tend to develop atherosclerotic plaques at locations where the blood flow is disturbed. So in my lab, we look a lot at what it is about that disturbed flow that makes the endothelial cells there dysfunctional and that leads to the atherosclerotic plaque development. Cindy St. Hilaire: That is so interesting. So I can picture how this is happening in a mouse at the bifurcation of different arteries but how are you able to model this in vitro? Can you describe the setup and then also how that setup can mirror the physiological parameters? Elisa Klein: Sure. So we have a couple of different systems we can use to model this and they all have their advantages and disadvantages, right? So a few years ago we made a system that's a parallel plate flow chamber. So you basically have your cells that you see that on a microscope slide and you use a gasket that's a given shape and that either drives the flow… Usually it drives the flow straight across the cells. So that's a nice laminar steady flow. And we see that the cells align and they produce nitric oxide in that type of flow which are measures that they are responding to the flow in vitro. So, a few years ago we made a device that actually makes the flow zigzag as it goes across the endothelial cells. And that creates these little pockets of disturbed flow and we did that in our parallel plate flow chamber. And that parallel plate flow chamber is really good for visualizing the cells. So you can stick it on a microscope. You can see what's happening, we can label for specific markers but it's not good for doing the things that we did in this Circ Research paper, where we want it to measure metabolism, because you need a lot more cells to measure metabolism and we needed a better media to cell ratio, so less media and more cells. So for this one, we designed and built a cone-and-plate device. So what it is, it's a cone and you spin that cone on top of a dish of endothelial cells and that cone produces flow. So it's going around in a circle. And if we just make it go around in a circle, it'll produce a steady laminar flow but if we oscillated it, so basically we kind of turn it back and forth, it'll make this oscillating disturbed flow. And then we have our dish of cells. We do this in a 60-millimeter dish and then we have a small amount of media in there and a lot of cells. And we can culture the cells in there for a while. Cindy St. Hilaire: That is so neat. And so I'm assuming that then your cone system is very tuneable. You could either speed it up, slow it down or change that oscillatory rate with different, I guess, shifts of it? Elisa Klein: Yeah, that's exactly right. So we can do all those things. It's programmable with a motor and so we can run whatever type of flow we want. Cindy St. Hilaire: That's great. So before your study, what was known regarding this link between hemodynamics and endothelial cell dysfunction and also endothelial cell metabolism? Because I feel like that's a really interesting space that a lot of people look at, kind of, metabolism and EC dysfunction or they just look at shear stress and EC dysfunction and you're, kind of, combining the three. So what was kind of the knowledge gap that you were hoping to investigate? Elisa Klein: Yeah, so we're really interested in macrovascular endothelial cell dysfunction. So this pro atherosclerotic phenotype that you can get in endothelial cells. And most of the work on endothelial cell metabolism had actually been done in the context of angiogenesis. So how much energy and how do cells get their energy to make new blood vessels? And that's more of a microvascular thing. So there was a study that came out before ours, actually, before we started this study, that was looking at how steady laminar flow could decrease endothelial cell glycolysis. And so that was after 72 hours of flow and they showed some gene expression changes at that time. Our study is shorter than that and we were still able to see a decrease in glycolysis in our cells in laminar flow. Before we started this study, no one had really looked at disturbed flow. So in the meantime, there are a few other papers that came out showing that the cells don't decrease glycolysis when they're in disturbed flow but not so much connecting them back to this function of making nitric oxide. Cindy St. Hilaire: So we were kind of dancing to the topic of O linked N acetylglucosamine or how do you say it? Elisa Klein: GlcNAC. Cindy St. Hilaire: GlcNAC? O- GlcNAC. So, O- GlcNAC is a sugar drive modification and I think it's added to Syrian and three Indian residues and proteins. Elisa Klein: Yup, that's right. Cindy St. Hilaire: Okay, good. And that modification, it does help dictate a protein's function. And you were investigating the role of this moiety on endothelial nitric oxide synthase or eNOS and so what exactly does this GlcNAC do for eNOS' function and under what conditions or disease states is this modification operative? Elisa Klein: Yeah. So there's some really important studies from a little bit ago that showed that eNOS gets GlcNAcylated in animals with diabetes, right? So if you have constantly high sugar levels, you get this modification of eNOS. The thought was that eNOS gets GlcNAcylated at the same site where it gets phosphorylated. But a more recent study came out and said, well, maybe that's not the case but it definitely gets GlcNAcylated somewhere where it affects this phosphorylation site. So it may be near it and prevent the folding or prevent the phosphorylation site availability. So if the eNOS gets GlcNAcylated, the thought is that it can't get phosphorylated and therefore it can't make nitric oxide. Cindy St. Hilaire: And so an interesting thing about this GlcNAcylation, which is probably the hardest thing I've ever said on this podcast, is that it's integrated with lots of different things. Obviously you need glycolysis and the substrates from the breakdown of sugars to make that substrate but also the enzymes that make that substrate are required. And so what's known about that balance in endothelial cells? Is there much known regarding the metabolic rate of the cells and this N-Glcynation? Elisa Klein: Yeah. So endothelial cells are thought to be highly glycolytic in terms of how they use glucose but they definitely take up glutamine to fuel the tricarboxylic acid or TCA cycle. And another paper came out a few years ago showing that quiescent and endothelial cells metabolize a lot of fatty acids. So they're fueling their energy needs that way. So there wasn't a lot known about GlcNAcylation in endothelial cells. A lot of this work has been done in cancer cells, which are also highly glycolytic but their metabolism actually seems like it's maybe more diverse than people have thought for a long time. So the weird thing about GlcNAcylation, which if you're used to working with phosphorylation there's a thousand different enzymes that can phosphorolate right. But with GlcNAcylation there's one enzyme that's known to put the GlcNAC on and one enzyme that's known to take it off. And so they're global, right? So in our studies, if we say, okay, we're going to knock down that enzyme, you're effecting every single protein in the cell that's GlcNAcylated. And obviously ourselves in particular, we're not a big fan of that. Especially once you put them in flow, they were, like, nope, we're not going to make it. Cindy St. Hilaire: Well, and that's a perfect segue to my next question because your results show that this flow really did not alter the expression of these enzymes that either add or subtract to the moiety. And rather it was the Hexosamine Biosynthetic Pathway that was decreased itself. So can you maybe give us a quick primer on what that is exactly and how that pathway feeds into the glycosylation... I think you wrote in the paper of over 4,000 proteins? So how would that fit in and why eNOS then? Elisa Klein: Yeah, so the Hexosamine Biosynthetic Pathway is one of these branch pathways that comes off glycolysis and there are these numbers sometimes there are these pathways out there and people say for the HBP in particular, 2% to 5% of the glucose that's going down through glycolysis gets shunted off into the HBP. We've done a lot of looking to try and figure out exactly where that 2% to 5%- Cindy St. Hilaire: Yeah, what exact percentage? Elisa Klein: Yeah, but some percentage of it comes down and we really thought there were going to be changes in these enzymes that do the GlcNacylation, we thought there might be changes in the localization of the proteins and it's possible that those things do occur. We just couldn't detect them in our cells. And in the end, what we showed was the main thing was that when you have cells and steady laminar flow, you just decreased glycolysis. And therefore, that 2% to 5% goes down. So you seem to make less of this UDP- GlcNAC, which is the substrate that gets put on to eNOS in this case. The really strange thing that we could not explain despite a lot of work and obviously we don't get to put all of our experiments that didn't work in the paper- Cindy St. Hilaire: The blood, sweat and tears gets left out. So- Elisa Klein: Exactly. So we tried really hard to figure out why it was eNOS specifically, right? Because in steady laminar flow, you see a lot of these like GlcNAcylated proteins and a lot of them didn't change but eNOS changed hugely, essentially this GlcNAcylation just went away for the cells and steady laminar flow. So we couldn't quite answer that. We're still working on that part of the question and looking at some of the other proteins that maybe get GlcNAcylated more in this case and trying to figure out what they are. Cindy St. Hilaire: I thought one of the cool results in your paper was one of the last ones. It was the one in healthy mice. In that you looked at healthy mice, just normal C57 black 6 mice that were 10 weeks old. So they just, kind of, reached maturity but you looked at their kind of these bifurcations and you looked at the inner aortic arch where there is more disturbed flow and you saw, similar to your in vitro studies, that there was this higher level of O-GlcNAcylation compared to the outer arch in the descending order. So my question is, these are healthy mice that are relatively young, they're not even full adults yet. That takes a couple more months. And so what are your thoughts about the role of this O-GlcNAcylation specifically on eNOS in driving atherogenesis. Where do you think this is happening in the disease process? It appears if it's in these wild type mice, it's already happening early. So where do you think this is most operative in the disease pathogenesis? Elisa Klein: I mean, I think it's very early, the effects of disturbed flow on endothelial cells. I can't imagine that there's a time when it's not having an effect on the cells. So I teach college students and I tell them all the time you think you're invincible now but these choices you're making today are going to affect your cardiovascular future in 50 years, which is very hard to accept. So I think it's very early in the process and I think it's only made worse by the things that we eat, in particular, that changed our blood sugar and our blood fatty acids and things like that. And our lab is looking into this more to try and see how when you change your blood metabolites then how does that then also affect this GlcNAcylation and the endothelial cell metabolism and then how does that affect endothelial cell function? Cindy St. Hilaire: Yeah. And it's funny, it's really making me think of those, kinds of, extreme diets like keto diets and things like that where you're just like depleting sugar. And obviously there's lots of controversy in that field, but if you just think about the sugar aspect what is that doing to those EC cells? Why do you think endothelial cells have this response? Meaning why do you think it is that they've adapted to induce a metabolic shift in response to disturbed flow? Because, obviously it's not going to be perfect laminar flow everywhere. So what do you think it is that provides some sort of advantage in the shift? Elisa Klein: That's a really good question. I haven't thought about the advantage that it might provide. There are a lot of things that are going on in this area of disturbed flow. So there is the shear stress, the differential shear stress that the cells are experiencing. There's also transport issues, right? So if you have this area of disturbed flow, you have blood and the contents of the blood, including the white blood cells and the red blood cells, everything else that's, kind of, sitting around in that area and not getting washed downstream as quickly. So it is possible that maintaining glycolysis provides energy for repair or for protecting the endothelial cell from some sort of inflammatory insult or something like that, that's happening in the area of disturbed flow. And I feel like I just read something recently, it was in a different genre but... if they stopped the increased glycolysis or stop the metabolic shifts, it actually was worse. Right? So I also believe that we treat humans for a single metabolic change, right? So if you have diabetes, I'm going to give you this drug and if you have high triglycerides, I'm going to give you this drug. But it's possible that if you have this metabolic abnormality, your body shifts the rest of your metabolism to protect the cells because of that metabolic abnormality. And so part of what we do as engineers is try and build computational models or we can take into account some of this complexity. So that's a really interesting question and my guess is that there are some protective aspects of this maintenance of high glycolysis and disturbed flow. Cindy St. Hilaire: Yeah, maybe it would be perfectly fine until we get athero and then it all goes awry. So in terms of... obviously it's early days and I know you're a bioengineer but in terms of translational potential, what do you think your findings suggest about future potential therapies or future targets for which we can use to develop therapies? Is modulating this O-GlcNAcylation itself, a viable option? Elisa Klein: I don't think that modulating it is a super viable option, right? Because as I said, when we tried to change those enzymes ourselves did not enjoy going through flow or anything else. So it's very hard to change it overall. What I think is these things that are coming out about how metabolism may shift for endothelial cells when they're activated versus when they're quiescent, right? So when laminar flow or cells are quiescent, they decrease glycolysis, they increase fatty acid oxidation. Those things are important to take into consideration when you are treating a person who has a metabolic disorder. So that's the biggest translational piece that I think is, how do we give therapies that modify the metabolism of a cell holistically instead of trying to hit one pathway in particular. We have done some studies where we tried to give endothelial cells something to inhibit a specific metabolic pathway and you see the cell shifts its entire metabolism to account for that. So we're starting to look at some of these other drugs like statins or metformin that do change endothelial cell metabolism, possibly even the SGLT2 inhibitors and trying to see not just how they change glycolysis but how they change metabolism as a whole and how that then affects endothelial cell function. Cindy St. Hilaire: So what are you going to do next on this project? Elisa Klein: So on this project, so we have some stuff in the works like I said on statins and how statins work together. And one of our big goals is to sort of build a comprehensive metabolic model of the endothelial cell. So this study really focused on glucose but there are other things that endothelial cells metabolize, glutamine, and fatty acids, and trying to look at some of those and then seeing how changes in the glycolytic pathway may affect some of those other pathways. We also have some really nice mass spec data part of which is in this paper but part of which is going to go into our next work, which is looking at how laminar flow impacts some of the other side branch pathways that are in metabolism and coming off of glycolysis as well as the TCA cycle, right? So we don't think of endothelial cells as being big mitochondrial energy producers but they do use their mitochondria. And so we think it's really interesting and part of our goal of building an endothelial cell model and then hopefully a model of the complexity of the whole vascular wall. Cindy St. Hilaire: Wow. That would be amazing. Well, Dr Elisa Klein from the University of Maryland, thank you so much for joining me today. This is an amazing study and I'm looking forward to seeing hopefully more of your future work. Elisa Klein: Thank you so much. It was a pleasure. Cindy St. Hilaire: That's it for the highlights the from October 29th and November 12th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes or #DiscoverCircRes. Thank you to our guest, Dr Elisa Klein. This podcast is produced by Asahara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy texts for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries and basic cardiovascular research. This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers on this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, visit AHAjournals.org.
Thank you for 26k streams! On this episode we feature these two up & coming Cinci queens! We talk it up about some wild times on Cinci Street, Dark Horse Days and Sofie lets us in on her little secret. Plus Nahtalya tells about her special talents and her ex boyfriends. We also got Louie of MadHouse and @ badgirlindsey on the show to chime in. Stream the entire video on my Onlyfans and follow me on social @ AaronScene!
Nov. 16, 2021 - Legal Aid Society staff attorney Kate Wood explains a new lawsuit designed to reverse state laws and practices that are keeping New Yorkers from raising their family members in foster care because of distant criminal records.
A Solo Podcast this week with Ayesha (@ayeshasehra). I am sharing all the affirmations, self-serving positive and life-enhancing daily practises that will set you up for a happier and a more abundant version of YOUR life. These are daily lessons, principles and practises I swear by that have profoundly changed my life for the better through operating with this ethos and mindset. Whatever life throws your way, remember it is ALL in our response in how you handle it. That is where the true power and magic lies in living your fulfilled and unapologetic life. Sending you all infinite amounts of love, gratitude and good vibes!! X share the love on socail if you get value from this pod: @coffeeandagoodvibe EPISODE SUMMARY: How to cultivate infinite faith in the journey you are on Blocking your blessings Intention Setting for your day Daily Morning Non-Negotiable routine to shape your day for abundance, success and happiness How life is always playing the role as your teacher Perception is everything Divine Timing and trusting the timeline / your process Relationships, GOOD AND BAD - are given to us for growth! How to view everything as a blessing The power of your environment Dealing with Negativity - negative people, low vibes in the environment Mindset/ ethos for a fulfilling and positive life Share the love & let me know your thoughts over on Instagram, @coffeeandagoodvibe | @ayeshasehra CONNECT: YOUTUBE ➟ Watch & subscribe to our channel here ➟ Coffee & A Good Vibe Video Interviews To connect with Ayesha Sehra ➟ click HERE Check out our podcast insta ➟ click HERE To learn about my Branding & PR Agency Grow The Social ➟ click HERE To connect with this week's guest click ➟ HERE
Hey mamas! It doesn't matter if you're working or are a SAHM, you can make another stream of income from home! But if you haven't taken that step YET, then one of these 4 reasons may be holding you back. In this episode you'll learn: How Other People's Beliefs or Negative Experiences is not your own. How the Fear of Failing is nothing to Fear. Why Old Identities Need to be Shed. Self-Doubt is your biggest Enemy. & I'll tell you how to Overcome all of these in order to STOP it from Blocking you from making money! -Kawai Connect -> email@example.com Instagram -> https://www.instagram.com/kawai_ahquin Community -> https://bit.ly/HEMsupportgroup Homeschooling Basics Bootcamp -> https://homeschoolingbb.weebly.com/
Anne asks for more information about the weird world of memetic warfare. Voodoo shares a strange story about a recurring dream that just might have predicted some events in the waking world. Bronze Ranked Boomer wonders about the efficacy of blue-blocking cosmetics. All this and more in this week's Listener Mail. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com
At least since the invention of the wheel, people have fixed, tinkered with, and improved every device they've possessed. It's been a human right. But after several thousand years, suddenly legal clauses are being tucked in purchase agreements saying that today's owners of products MUST NOT even peek, much less poke inside the inner workings of our devices. Makers of anything with a computer chip in it (everything from your car to your toothbrush) have been especially vehement about this, rewriting human nature by outlawing our right to repair. Yes, they assert, you own the thing, but we own the intangible ideas that make it work, so if the product malfunctions, you must return it to us – and pay us a premium – to repair it. Plus, they prattle, you could hurt yourself trying to do-it-yourself, so trust us. Bovine Excrement, barks Steve Wozniak: Companies inhibit your rights so they can have “power, control, over everything.” Is he, some consumer radical? No, Wozniak is the co-founder of Apple, the multibillion-dollar global goliath that is the world's biggest producer of consumer electronics. He's appalled that Apple has now become a fierce opponent of self-repair. He says “We wouldn't have had an Apple” except that early innovators like him grew up “in a very open technology world.” From the start, Wozniak point out, openness helped spread innovation and consumer demand. “So, why stop... the self-repair community,” he asks? Two big reasons: Besides letting corporations lock in monopoly profits from the repair industry, it also dissuades customers from bothering with repairs – just throw the thing away and buy a new one! If you wonder where such massive, deadly levels of pollution by bead, mercury, plastic, etc. come from, look to the gross throw-away ethic of big tech profiteers like Apple.
Biden Admin OPENLY Abuses Power, Orders Vaccine Mandate DESPITE Court Blocking Him, GOP Must IMPEACH. Republicans may be in for a red wave in 2022 and if they win they must file for impeachment of joe biden over the Ukraine Scandal and the constant abuses of power. Democrats are seeing failing approval, Biden approval is at al all time low and disapproval is skyrocketing. People are fed up with Democrats chasing unpopular policies and causing inflation and soaring gas prices. #Biden #Democrats #Republicans Become A Member And Protect Our Work at http://www.timcast.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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You have a creative idea. You feel inspired to pursue it. But your head is filled with doubt. “What if I can't make it work? What if I can't provide for my family? What if my work isn't good enough? What if people think my creation is stupid?” We have a guest on the show […] You can listen to this episode How to Keep Fear from Blocking Your Creativity with David Lee Martin on Christian Publishing Show.
You have a creative idea. You feel inspired to pursue it. But your head is filled with doubt. “What if I can't make it work? What if I can't provide for my family? What if my work isn't good enough? What if people think my creation is stupid?” We have a guest on the show […] You can listen to this episode How to Keep Fear from Blocking Your Creativity with David Lee Martin on Christian Publishing Show.
Are you tired all the time? Headaches migraines weekly or monthly? Digestive upset that won't quit? Anxiety like you've never had before and sleep so disturbed that you can literally feel your body aging faster than it should? As I've said before, It's not about the food. You are definitely going to want to listen up to the expert guest I have on today who will leave you wide-eyed and amazed at how your home (and even your car) could be making you sick. And we aren't talking mold here. I have a passion for helping my clients and my listeners mitigate the dangerous effects of electromagnetic radiation from our devices, our phones, wifi, bluetooth, and cell towers because you guys, this is real, it's published in the research, and it's getting worse that EMF is a major part of our health decline. I myself am highly sensitive to it and have to take extra precautions in order to live in this modern tech world and not be too affected by it. And that's why I am honored to welcome my next guest who I have been trying to get on my podcast for quite some time so I'm so glad he is here. Brian Hoyer is a fellow Functional Nutritional Therapy Practitioner, like myself, trained with the NTA so we definitely have that in common and, has trained with The highly regarded Klinghardt Academy, and become a certified Geo-biologist trained by a pioneering naturopathic and environmental medicine clinic in Austria that's been addressing EMF and geopathic stress since 1983. He is founder of Shielded Healing, a company with the goal of helping modern humanity recreate their home environments that more closely mimic our historic human habitats, and help you regain your health instead continue to get sicker and sicker. In this episode we talk sleep, digestive issues, lack of hormones and why the major issues plaguing most people today could be do to their home environment and the mass amount of radiation they are exposed to. You are going to love Brian's company and how they will personally set up a time to come to your residence and shield you as well as educate you from harmful EMF. And my listeners receive a special promo code: JODELLE ..... This offers $100 off any of their EMF services. http://shieldedhealing.com/discount/JODELLE?aff=61 And Thank you to our show sponsors: Swanwick Sleep Blue-light Blocking glasses: https://www.bn10strk.com/GETFIT/ and use code: FITFOR10 MOS Shielding Equipment https://mosequipment.com/?ref=cGFWJ1 COUPON CODE: JODELLE FOR 5% OFF Microbe Formulas - Mimosa Pudica is the best supplement I have found to help eliminate gut pathogens and enhance your EMF-resisting gut bacteria https://bit.ly/3lqn3oH
In this bonus episode of Dear Gabby, you'll hear a talk from my Judgment Detox book launch event. If you haven't heard me speak live, I think you'll really enjoy this! On stage is where I light up, and I was super inspired to share these life-changing tips with my audience. In this talk, I explain the 6 steps for releasing judgment. If you practice this method, you'll feel more free than you ever have before—and that's a guarantee. Join me for this live talk to learn: A simple morning ritual that will help you live in faith every day How to witness your judgment without judgment How to honor your core wounds to get to the root cause of your judgment How to release resistance so that miracles can occur naturally in your life How to shut down your inner critic and show up for your gifts (this is SO important!) Why I KNEW I had to write Judgment Detox to begin with, and how the book can serve you Don't worry—I don't expect you to never judge anyone or anything again. You're human, and that's okay! But if you diligently apply the steps I lay out in this talk, you won't believe your judgments anymore. RESOURCES: The following are helpful resources and books I mention within the episode: Happy Days book preorder & Live Virtual Event Experience Want a FREE VIP ticket to the biggest event of 2022? When you preorder the book, Happy Days, you'll score a FREE ticket to the Live Virtual Event Experience on February 26, 2022! Claim your spot here: http://deargabby.com/happydays FREE TRAINING: Need some inspiration? I just dropped a FREE training that will crack you wide open to creative possibilities. It's called: Your 5-Step Guide to Unlock Purpose & Abundance. You can get it for free, right now, at DearGabby.com/purpose. Here's what you'll learn: My method for thriving in financially insecure times The #1 reason you're blocking your dreams, and how to fix it The only thing you need to prioritize to fulfill your purpose How to stop pushing and take action with confidence This one is maaaaaajor — you don't want to miss it! BOOKS & CARDS Judgement Detox: gabbybernstein.com/judgment-detox-book MIRACLE MEMBERSHIP Want even more support? I created the Miracle Membership to help you design a spiritual practice you can stick to—so you can feel connected, supported and inspired every day. Each month I deliver brand new workshops, guided meditations, live group meditations, community connection, and so much more. Plus, it's easy to access on your phone, computer or tablet. Click here to join: https://bit.ly/3xBSsat PARTNERS To access a free sample class and learn how you can save 30% on tuition right now, visit integrativenutrition.com/deargabby Go to FLEXFITS.com/gabby and use code gabby for 20% off Flex Disc Starter Kits—or 10% off your first Flex Cup—PLUS free U.S. shipping! Produced by Dear Media.
Thank you for over 25k streams! For episode 65 we feature the man the myth, the legend, Chuck Daddy Debroder. We get to know him and how we came to be the the weather icon he is today. He also lets us in on some hypnosis tips and tricks and even hypnotizes our girl Naomi. Plus he tells us some throwback news room horny stories and the time he ran into the great Michael Irvin here in El Paso. Make sure to stream & subscribe and catch the full video on my Onlyfans! Follow me on social media @ AaronScene. Onlyfans.com/aaronscene
Have you been feeling like your life has been at a standstill lately? Do you feel like every time you take one step forward, then life takes you two steps back? Have you been asking God for a blessing or help with a situation and you just feel like he's not listening to you? Trust me when I say... I've been there Here is the thing, God is always right here with us and he always helps us in His perfect timing. It could be that He is listening to you, but you're blocking your own blessings. This happened to me a little while back, and I really wanted to come on here and do this episode because I know someone is struggling right now and they just feel like they're at a standstill, and it could be you reading this right now. You just feel like the blessing that you're so desperately looking for is not coming your way and you just don't understand what's going on. So today I'm going to go into my story of blocking my blessings, I'm going to pair it with some scripture, and then also give you three things to implement to help you let go of whatever's holding you back, to fully stay obedient, and to trust the Lord. Enjoy! For the study guide, join this group and check out the units tab. This episode's show notes: https://www.faithfuelsmyfire.com/post/are-you-blocking-your-blessings If you want to check out previous Bible studies, click here Email me: firstname.lastname@example.org Facebook Community: https://www.facebook.com/groups/486483515603028/ YouTube Channel: https://www.youtube.com/channel/UCmBsSKktGU_8WHVNIxhFuzg The Bible App that I use: http://bible.com/app Instagram: @_lorenacamille_ Never Forget to Choose Faith Over Fear, -Lorena Camille
If you want to find out what's keeping you stuck and sick, book a free mini-consult with us to receive specific recommendations: caseyshipp.com/miniconsultSupport the show (https://caseyshipp.com/)
On this episode, Josh talks about how he is developing and improving his skills as a content creator. He reveals a few key mistakes that he's learned which may hopefully keep you from making the same mistakes while creating your own content. Josh continues on by talking a bit about why he likes to wear the Ra Optics blue-blocking lenses. And he takes a deep dive into one of his favorite biohacking wearable devices called the Hapbee, the technology that allows you to actually choose your mental and physical state. Enjoy the show! __ Full Video Episode on youtube: https://youtu.be/T7n3HgRaH-o __ Ra Optics: http://www.raoptics.com/discount/joshuajholland?redirect=%2F%3Fafmc%3Djoshuajholland Discount code: joshuajholland Hapbee: https://hapbee.com/JOSH Discount code: JOSH Riverside.FM: @Riversidefm https://riverside.fm/?utm_campaign=campaign_1&utm_medium=affiliate&utm_source=rewardful&via=josh-holland
In this episode, I'm talking about ways in which you may be blocking yourself from receiving money. How to Support the Podcast: Subscribe to the podcast on iTunes, Stitcher, Google Play or wherever you listen to podcasts. Please like, share, and leave a review. If you like the content, please share with your friends by posting on social media so that we can reach and impact more people. If you want to purchase any of the books that we discuss, please use the link in the notes to shop on Amazon. In fact, if you shop on Amazon at all, then use our link to help support the podcast. https://www.amazon.com/?tag=weddbyheat-20 Connect: Heather Lahtinen: Website, Facebook, Instagram
On this episode of The Built in Seattle Podcast, I talked with Julian Alvarez, CEO & Co-Founder at Logixboard.For more stories and lessons from startup life in Seattle, subscribe to my weekly emailEpisode HighlightsHow to stay sane when people say you're crazy.No tech founder + No domain expertise = ??Selling first customers from PowerPointMoving to Columbia to sit with an early customer.The 50+ rejections, 7 months, and 6 flights that it took to land the first customer.Smiling about mistakes. The formula for raising money. Behind the scenes on Logixboard series A.Why Symbol.ai is Julian's Seattle business role model.Why Jon Gelsey is Julian's Seattle leadership role model.Where to follow Julianhttps://www.linkedin.com/in/julian-alvarez-751943126/Where to follow Adam:https://www.linkedin.com/in/adamschoenfeld/https://twitter.com/schoenyFeedback? Suggestions on who to interview? Email me anytime - email@example.com
It's the collab you never expected, Fulhamish talking basketball. It was necessary due to Marco Silva's side scoring from another corner that involved a blocking routine. Peter gives us the lowdown, following his piece where he spoke to two NBA experts from The Athletic about the tactic. In part two, we discuss the club's decision to halt their search for a Director of Scouting. What does this mean for Fulham's transfer recruitment? Are we looking at more short-termism when it comes to our signings? Finally, we break the 'opposition preview glass' ahead of this Saturday's massive game against West Brom by speaking to Louis Bent from The Baggies Podcast. Learn more about your ad choices. Visit megaphone.fm/adchoices
Just when Liv and Lex thought the all about love series was over, they couldn't leave the conversation without talking about how to handle heartbreak and getting over an ex. What is your strategy? Blocking or staying friends? Well tune in to hear Liv and Lex give their advice on how to get over an ex and reclaim your peace.
Presenters: Jake Lancaster MD, Chief Medical Information Officer and Pamela Popp JD, Chief Risk Officer for Gallagher Bassett Understand the information blocking rule and implications for your practice Learn about ways you can improve your documentation Learn about the risks of noncompliance with the information blocking rule CME Credit Info: Link to complete brief survey and claim CME credit: https://www.surveymonkey.com/r/C55LKSY (https://www.surveymonkey.com/r/C55LKSY) CME credit is available for up to 3 years after the stated release date Contact CEOD@bmhcc.org if you have any questions about claiming credit. Faculty Disclosure: None of the hosts or guests have relevant financial interests to disclose. It is the policy of Baptist Memorial Health Care Corporation (BMHCC) to promote balance, independence, objectivity, and scientific rigor in all educational activities; to require disclosure of relevant financial relationships from individuals engaged in content development or planning of a CME activity; to identify and resolve conflicts of interest related to those relationships; and to make disclosure information available to the audience prior to the CME activity. Presenters are required to disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentations.
If your computer is currently running Windows 10, like most Windows computers currently are, there's a new major update that's just been released – it's Windows 11. It's not something you want yet. For quite some time, Microsoft said that the last version of Windows would be Windows 10. They said they would just continue to [...] Read more » The post Blocking Windows 11 from coming in first appeared on The Computer Tutor.Download Ashford for WordPress
Thank you for 24k streams! For this episode we got our girls Aileen and Melissa and it is a horny one! We talk about Aileen's time as a dancer, her premium snapchat days (which was *chef kiss*) and Melissa tells us about her two boys story. Catch the full video action on my OnlyFans and follow me on social media @ AaronScene! Onlyfans.com/aaronscene
Support the show: https://www.buymeacoffee.com/HawkVision Mr. Mike Zeller is an extremely accomplished business owner and performance coach that helps people across the country identify their area of genius. With over 12 successful businesses generating over 300 MILLION dollars in revenue, Mike Zeller knows what success looks like in both mindset and execution. In perhaps one of the most thought-provoking interviews to date, Mike directly speaks to the positive impact of investing in himself through several classes with Anthony Robbins. We discussed the entrepreneurship in its purest form, which will help new business owners uncover the things that we often overlook that block our zone of genius. If you've ever wanted to hear from a multi-million dollar business owner share the secrets of his success in a way that lets you take actionable “next steps”, this interview is for you.Guest Site: https://mikezeller.com/about/Guest Social: https://www.instagram.com/themikezeller/?hl=enHost Site: https://www.hawkvisionpodcast.com/Host Social: https://www.instagram.com/hawk_vision_/?hl=en #MikeZeller#ChuckHawkins#BestBlackPodcast#BlackShowHost#MindsetMastery#MilliionaireMindInterview#ZoneOfGenius#TheGeniusWithin#NewEntrepreneurs
I am interviewing my daughter, Alexis, on the things that have blocked her from manifesting, signs from the universe, positive thinking, and how to believe with unwavering faith that your big goals will manifest. Free 5-Day Law of Attraction Course: https://www.subscribepage.com/j8n1q0 Text HELLO to (855) 997-1687 to get my Abundance Subliminal Manifestation Bundle Tag me on Instagram @lawofattractiontribe and I'll tag you back! Law of Attraction Shop: https://www.etsy.com/shop/LawOfAttractionTribe?ref=simple-shop-header-name&listing_id=709752750 Law of Attraction Free Resources: https://thelawofattractiontribe.com/free-resources/
All that stuff in the title and loads more. Recorded on location in Cyprus.
In this episode, we talk about the most effective team blocking strategies so you can decide which one would be best for your team. Topics include: A bunch read system A spread system Commit system Middle blocking strategies Pin blocking strategies And a few more items Click here to join the waitlist for Digital Volleyball Academy Reach out to me via Instagram @BrianSingh_CoachB
PROF Olle Johansson is here with again for a third podcast, so thrilled Olle Johansson, who I have now coined my Swedish father, because my maiden name used to be the same as his, and I really look up to him for his research on something I am extremely passionate in, which we will be jumping into in just a moment but for those of you who don't know much about Prof Johansson, I highly recommend listening to the two previous podcasts we did which will blow you HAIR BACK, due to the knowledge he brings on the dangers of the internet of things, 5G, the coming 6G, 7G and more. Olle Johansson is a professor, and head of Experimental dermatology in the department of Neuroscience at the prestigious Karolinska Institute in Stockholm, Sweden. Olle is a world-leading authority in the field of EMF radiation and health effects. He has published more than 500 original articles, reviews, book chapters and conference reports within the field of basic and applied neuroscience and is more recently researching something I am so interested to talk with him today on which is electro hyper sensitivity (EHS) is an officially fully recognized functional impairment. We discuss: Smartphones and weight gain How EMF affects your gut bacteria!!!! New Research! Smartphones, EMF and sleep health Smartphones and cancer Smartphones and children's health Internet of things and health implications What's happened to the bees Dangers of too much time on social media And much more! PROF Olle Johansson is doing some incredible work and would greatly benefit from our help. Please consider donating to his fundamental work here: https://honeywire.org/research (Always remember that no gift is too small, and Dr. Johansson's work needs this economic support so he would be able to continue quality research work regarding the adverse health and biological effects of artificial electromagnetic fields from cell phones, satellites, smart meters, WiFi, baby alarms, powerlines, and many more installations.) Resources mentioned: Johansson O, "To bee, or not to bee, that is the five “G” question", Newsvoice.se 28/5, 2019 https://newsvoice.se/2019/05/5g-question-olle-johansson/ But perhaps you also can use some of these, with their web links? Johansson O, "Bacteria, mobile phones & WiFi - a deadly combination?", Nya Dagbladet 31/5, 2017 https://nyadagbladet.se/debatt/bacteria-mobile-phones-wifi-deadly-combination/ Johansson O, "Associate professor: Wireless radiation – the biggest full-scale biomedical experiment ever done on Earth", Newsvoice.se 5/8, 2018 https://newsvoice.se/2018/08/wireless-radiation-biomedical-experiment/ Johansson O, “Is the ‘electrosmog' finally clearing?”, Newsvoice.se 4/2, 2019 https://newsvoice.se/2019/02/electrosmog-clearing/ Johansson O, Ferm R, " “Yes, Prime Minister” Stefan Löfven, but no! This is not good enough!",Newsvoice.se 3/5, 2020 https://newsvoice.se/2020/05/stefan-lofven-5g-microwave-radiation/ Santini R, Johansson O, "If 5G is not deemed safe in the USA, and nowhere in the rest of the world, by the insurance industry … why is it by the Danish government?", Newsvoice.se 8/7, 2020 https://newsvoice.se/2020/07/5g-not-safe-usa/ Johansson O, Rebel TK, McGavin B, "Global 5G protest warns of health and ecological costs", Newsvoice.se 5/9, 2020 https://newsvoice.se/2020/09/global-5g-protest-warns-of-health-and-ecological-costs/ Johansson O, "Fuck your telephone?", Newsvoice.se 17/3, 2021a https://newsvoice.se/2021/03/olle-johansson-fuck-your-telephone/ Johansson O, "Cars, humans, laws, artificial electromagnetic fields … but what about the future?”, Newsvoice.se 9/8, 2021b https://newsvoice.se/2021/08/associate-professor-olle-johansson-artificial-electromagnetic-fields-future/ Thank you to our show sponsors: Swanwick Sleep Blue-light Blocking glasses: https://www.bn10strk.com/GETFIT/ and use code: FITFOR10 MOS Shielding Equipment https://mosequipment.com/?ref=cGFWJ1 COUPON CODE: JODELLE FOR 5% OFF Microbe Formulas - Mimosa Pudica is the best supplement I have found to help eliminate gut pathogens and enhance your EMF-resisting gut bacteria https://bit.ly/3lqn3oH
October 15, 2021: Charles Boicey, CTO for Clearsense talks call centers, development, data science and information blocking with Bill. We need call centers to support so many parts of our conversation with the patient but they are not optimal. What is possible? What are the best practices? Where do development projects go off the rails? How do you manage outsource development partners? And where do we start with app development? How are we going to manage the information blocking rule? Is there any way to ensure our patients that the PHAs that connect to our EHR and request data on their behalf are safe?Key Points:NLP - Natural Language Processing and NLU - Natural Language Understanding [00:06:15] It's really important that you future-proof your assets [00:11:15] Development projects go off the rails initially when whatever we've conceived isn't in alignment with the board [00:18:38] What does low-code no-code look like? [00:23:16] Too much black boxing is going to hurt healthcare [00:34:25] Clearsense
Bert used to give Moe a hard time for blocking multiple people on his social media accounts. But today, the tables have turned. Bert is going on a blocking spree, but for good reason. See acast.com/privacy for privacy and opt-out information. Become a member at https://plus.acast.com/s/the-bert-show.
To carry anger within you over what someone did to you is to degrade your creativity, productivity and serenity.Being mistreated is nothing more than a training camp to build your strength to forgive.And to forgive really is to be strong and powerful versus weak. And meek.When you harbor resentment, you miss the glory of the present moment. You're living in the past. The grudge is burning away at you. Blocking your mastery. And silencing your music.So how can you let it go?......simple, you let it go.You make the choice to move on with your life, understanding that un-forgiveness is like carrying the person who hurt you on your back. Pretty draining, right?You set the intention to be the bigger person and seek the growth in whatever happened, letting your pain purify you. And make you kinder and wiser.And you work to develop the awareness that people do the best they can based on the level of wisdom and awareness they have at that time.So, forgive. Today. Please.If you want to encode Robin Sharma's finest methods and strategies [well beyond what he shares in his #1 bestseller The Everyday Hero Manifesto] to escalate your positivity, accelerate your productivity and magnify your impact on the world......with him as your personal mentor for the next 12 months...Claim one of the limited memberships to Robin Sharma's premium digital course, The Everyday Hero Manifesto Method here.The Everyday Hero Manifesto Method offers a step-by-step system to multiply your success in your professional and personal life, with him as your personal mentor for one year.FOLLOW ROBIN SHARMA:InstagramFacebookTwitterYouTube
Are there any guarantees to having your retirement account remain accessible? In this video, Andrew shares an article about how one country is blocking the retirement money of citizens who are leaving to go where they're treated best. 00:00 Start 0:43 Where should you put retirement money? - IRA - Roth IRA 1:37 ''China Is Blocking Fleeing Hong Kongers From Getting Their Retirement Money'' 4:32 Ways to Protect your retirement savings https://nomadcapitalist.com/ Andrew Henderson and the Nomad Capitalist team are the world's most sought-after experts on legal offshore tax strategies, investment immigration, and global citizenship. We work exclusively with seven- and eight-figure entrepreneurs and investors who want to "go where they're treated best". Work with Andrew: https://nomadcapitalist.com/apply/ Andrew has started offshore companies, opened dozens of offshore bank accounts, obtained multiple second passports, and purchased real estate on four continents. He has spent the last 12 years studying and personally implementing the Nomad Capitalist lifestyle. Our growing team of researchers, strategies, and implementers add to our ever-growing knowledge base of the best options available. In addition, we've spent years studying the behavior of hundreds of clients in order to help people get the results they want faster and with less effort. About Andrew: https://nomadcapitalist.com/about/ Our Website: http://www.nomadcapitalist.com Subscribe: https://www.youtube.com/subscription_center?add_user=nomadcapitalist Buy Andrew's Book: https://amzn.to/2QKQqR0 DISCLAIMER: The information in this video should not be considered tax, financial, investment, or any kind of professional advice. Only a professional diagnosis of your specific situation can determine which strategies are appropriate for your needs. Nomad Capitalist can and does not provide advice unless/until engaged by you.
Welcome to episode 63! For this After Party we got our guy Dom the Cincinnati DJ Whore himself and we talk about his life and time in El Paso and on Cinci Street, his little love triangle and he tells about his most embarrassing sex story. Plus Sabring joins us and takes off some clothes for the vibes. Catch the full video on my OnlyFans and follow me on social media @ AaronScene! Onlyfans.com/aaronscene
Dan and Nick break down the All-22 coaches film of the Giants' Week 5 loss to the Cowboys. They talk about the play calling from Jason Garrett, Daniel Jones' early struggles, what they saw from Matt Peart compared to Nate Solder, Kadarius Toney's breakout and more Learn more about your ad choices. Visit podcastchoices.com/adchoices
A Swiss Federal Institute of Technology robotics engineering student Ken Pillonel stuffed a USB-C port that can transfer data as well as charge into an iPhone X. A San Francisco court orders Tesla to pay $136.9 million to a former contract employee who alleged discrimination and hostile work environment, and Microsoft and Nvidia created the Megatron-Turing Natural Language Generation model or MT-NLP which they call the “most powerful monolithic transformer language model trained to date”. Starring Tom Merritt, Sarah Lane, Stephanie Humphrey. Roger Chang, Joe, Amos MP3 Download Using a Screen Reader? Click here Multiple versions (ogg, video etc.) from Archive.org Follow us on Twitter Instgram YouTube and Twitch Please SUBSCRIBE HERE. Subscribe through Apple Podcasts. A special thanks to all our supporters–without you, none of this would be possible. If you are willing to support the show or to give as little as 10 cents a day on Patreon, Thank you! Become a Patron! Big thanks to Dan Lueders for the headlines music and Martin Bell for the opening theme! Big thanks to Mustafa A. from thepolarcat.com for the logo! Thanks to our mods Jack_Shid and KAPT_Kipper on the subreddit Send to email to firstname.lastname@example.org Show Notes To read the show notes in a separate page click here!
A Swiss Federal Institute of Technology robotics engineering student Ken Pillonel stuffed a USB-C port that can transfer data as well as charge into an iPhone X. A San Francisco court orders Tesla to pay $136.9 million to a former contract employee who alleged discrimination and hostile work environment, and Microsoft and Nvidia created the Megatron-Turing Natural Language Generation model or MT-NLP which they call the “most powerful monolithic transformer language model trained to date”.Starring Tom Merritt, Sarah Lane, Stephanie Humphrey, Roger Chang, Joe.Link to the Show Notes. See acast.com/privacy for privacy and opt-out information.
Josh Youssef from Help The Persecuted stops by to explain how our own state department is now blocking their efforts to get stranded Americans our of Afghanistan and democrats continue their hard push to control social media in order to tamp out conservative speech.
Josh Youssef from Help The Persecuted stops by to explain how our own state department is now blocking their efforts to get stranded Americans our of Afghanistan and democrats continue their hard push to control social media in order to tamp out conservative speech.
In football, there are two things players need to get really, REALLY good at before they can start thinking about advanced strategies and complex plays.Those two things are blocking and tackling.These are the fundamental actions of the game.Real estate investing has its own blocking and tackling.Whether you're flipping or wholesaling houses, there are two fundamentals you have to get good at if you want to succeed.At Flip Hacking LIVE a couple years ago, Andy McFarland shared what these two things are and how to get good at them even if you're a complete beginner. This is one of my favorite presentations from any event we've ever held…And it will give you a taste of what's in store at Flip Hacking LIVE next week.Let's dive in to “blocking and tackling” for real estate investors…Listen in now!There are SO MANY huge takeaways in this presentation.Every year, guys like Andy McFarland take the stage at Flip Hacking LIVE to share things like this. Each session alone is more than enough to accelerate your real estate investing growth…And you get THREE FULL DAYS of this.If you haven't gotten your ticket to Flip Hacking LIVE by now, I'm not sure what's holding you back… but the price is going up TOMORROW.Hit the link below to register!CLICK HERE to Get a Spot at Flip Hacking LIVE 2021 >>The event is happening October 14-16 in Orlando, FL.It's going to be awesome. I can hardly wait…See you there!Links and ResourcesFlip Hacking LIVE tickets for October 2021 are available now… and seats are filling up fast. If you want to learn the exact systems and strategies the nation's top house flippers and wholesalers are using to flip 100s of houses per year, reserve your spot today. Hit the link below to sign up!- CLICK HERE: FlipHackingLIVE.comIf you're an experienced real estate investor and you're ready to get around a community of active house flippers and wholesalers who will support you, hold you accountable, and push you to set goals that inspire you as you grow your business, check out 7 Figure Altitude and see if it looks like a good fit. If it is, I invite you to fill out a quick application to join. If you have any questions, reach out!- CLICK HERE: 7FigureAltitude.com====================Want to continue your house flipping / wholesaling journey? Here are a few more resources to check out...Subscribe: Join the 7 Figure Flipping email list to get the latest house flipping and wholesaling secrets, plus insider access to real estate investing tips, training, and more! Click Here: https://7figureflipping.com/subscribe7 Figure Flipping Podcast: Subscribe and get more episodes like this one delivered to you every week! Click Here: https://7figureflipping.com/listenFacebook Group: We've built a community of serious investors who are learning and growing their businesses together. Join the Group on Facebook: https://www.facebook.com/groups/fliphacking/7FigureFlipping.com: Learn more about who we are, our mentoring groups, upcoming events, and the causes we support at our website. Plus, grab some free downloads and other materials to help you on your real estate investing journey! Click Here: https://7figureflipping.com/ See acast.com/privacy for privacy and opt-out information.
In this Hasty Treat, Scott and Wes talk about how much modern web development has taken from PHP! Freshbooks - Sponsor Get a 30 day free trial of Freshbooks at freshbooks.com/syntax and put SYNTAX in the “How did you hear about us?” section. LogRocket - Sponsor LogRocket lets you replay what users do on your site, helping you reproduce bugs and fix issues faster. It's an exception tracker, a session re-player and a performance monitor. Get 14 days free at logrocket.com/syntax. Show Notes 03:56 - Why much of modern web development is just recreating PHP Everyone loves to hate on PHP, but modern Web dev takes a lot from PHP 05:44 - Mixing templating and logic We do this with JSX 07:39 - Each request has its own scope 08:57 - Massive standard lib Format a date? No sweat! Image resizing? Sure! Audio bindings? Sure! 10:16 - URL-based routing Next.js pages Serverless functions 11:13 - Server-rendered Hotwire 11:38 - $_GET, $_POST, are just available Next.js hooks 12:29 - Variable interpolation 12:59 - All-in-one frameworks Laravel did it CakePHP CodeIgnighter 13:32 - Direct DB access SQL statements 14:37 - Why do people hate PHP? WordPress Inconsistent API Their first code was PHP and they sucked PHP has come a long way It used to not be safe Blocking by default - no async/await 17:48 - Why is JS still better? Shared code between frontend and backend Single language Huge ecosystem (could be a con) Links Syntax 267: Hasty Treat - Turbolinks + Server Generated HTML + JS Sprinkles https://vuejs.org/ https://www.hey.com/ Tweet us your tasty treats! Scott's Instagram LevelUpTutorials Instagram Wes' Instagram Wes' Twitter Wes' Facebook Scott's Twitter Make sure to include @SyntaxFM in your tweets
Once you decide to make a career change, you'll have many roadblocks and mental barriers to overcome. Often, people allow their own fears to stand in the way to make that change. You know that you NEED to change, but you don't see how you can actually pivot to where you want to go. After working with people for years, it's been proven that the hard work, endless days, sleepless nights, and the energy it took to make a successful transition in their career is worth it in the end. To binge-listen to more career happiness success stories, find all the podcasts at https://happentoyourcareer.com/podcast Want to know high-performers discover their ideal career and find meaningful, well-paid work without starting over https://www.happentoyourcareer.com/career-change-advice-guide-backed-by-research/ Email Scott@happentoyourcareer.com
Joy Reid leads this episode of The ReidOut with the wait to see if Speaker Pelosi will bring the bipartisan infrastructure bill to the House floor for a vote on Thursday night, which per her history, Pelosi would likely only do if it will pass. Rep. Pramila Jayapal of Washington, chair of the Congressional Progressive Caucus, joins Joy Reid to discuss. Then, the select committee on Jan. 6 is moving forward in high gear issuing 11 new subpoenas Wednesday night to those involved in planning, promoting and financing the rallies that precipitated the siege on the Capitol, including the so-called “Stop the Steal” rally. Rep. Adam Schiff of California joins The ReidOut on these developments. Plus: There is a new Republican figure looming over the politics landscape -- Glenn Youngkin, the Republican running for governor of Virginia against Democratic former governor Terry McAuliffe. Is he hiding an ultra-conservative side from voters? Finally: Joy critiques the extremely rich who are doing everything they can to avoid paying taxes. All this and much more in this edition of The ReidOut on MSNBC.
This episode is about finding your passion by releasing repressed anger. Today's caller, Illarion, feels lost. He is in his twenties and is struggling to find his purpose. Emotions from his childhood are bubbling to the surface of his unconscious. If you relate to this call and feel blocked, anxious, or lost, this episode will help you tap into your fire and find your voice. [For show notes, go here: Christinehassler.com/episode316] So many of us that may be dealing with anxiety, depression, or feeling lost have a bit of indifference, hopelessness, and apathy we can slip into. That is a dangerous place because there is numbness. Whereas anger, if understood and expressed in a healthy way, is a very useful emotion. Anger is often the gateway to reaching our deeper hurts and it's the thing that unleashes our passion. Repressed anger takes up a lot of energy. It is a fiery emotion that just sits inside of us. Passion is fire too. If we have a lot of anger that we haven't processed, it can be a block to our creativity and passion. A lot of creative and artistic people have trouble accessing their anger. It ends up manifesting as anxiety. When we have the creative archetype, there is also gentleness. We want to be the peacekeeper and avoid conflict. We don't feel the warrior spirit because we are more on the creative side. However, when we don't access our anger and our rage, it can hold our passion back. It is often anger and resentment that keep us from getting to the true energy of forgiveness. Join us for our LIVE Inner Child Workshop on October 8–10th. It will be the last live inner child workshop taught by Christine and Stefanos for a while. Get live coaching or attend the workshop online ChristineHassler.com/InnerChild. Consider/Ask Yourself: Do you feel stuck or lost in your life? Did you have parents that supported who you are but not 100% of the time? Have you analyzed and talked about your issues and have been in therapy but things are not changing? Is anger something that turns you off? Illarion's Question: Illarion feels lost and is struggling to find his purpose. He goes through bouts of loneliness, anxiety, and low self-worth. Illarion's Key Insights and Ahas: He moved to New York City. He is going through imposter syndrome. He doubts every choice he makes. His feelings go up and down. He may have unresolved issues from childhood. He has been in therapy for three years. He looks at what he should be instead of what he is meant to be. He didn't feel he was able to be himself as a child. What he is going through is normal for his age. He is not sure he is lovable and enough for his parents. He doesn't speak with his father. He hasn't dealt with the anger he feels at his parents. He seeks approval from other people. He wanted someone to stick up for him as a child. How to Get Over It and On With It: Tap into his anger and be pissed. Do the temper-tantrum technique at ChristineHassler.com/angerrelease Write an F-U letter to his mom and dad without sending it to them. Go to a quiet place and expel rage while he punches a pillow. Find his fiery passion. Sponsor: SOUL CBD — is a daily supplement to calm the nervous system and re-calibrate homeostasis. Soul CBD gummies, liquids, oils, topicals, and bath bombs are all 3rd-party-tested for toxins. Bring balance into your life and get 15% off AND free shipping in the U.S. at MySoulCBD.com/OVERIT Resources: Christine Hassler — Join the Free Over It and On With It Community Christine Hassler Podcasts Including Coaches Corner Christine on Facebook Expectation Hangover, by Christine Hassler @ChristinHassler on Twitter @ChristineHassler on Instagram @SacredUnionCouples on Instagram Assist@ChristineHassler.com — Males who want to be on the show Jill@ChristineHassler.com — For information on any of my services Get on the Waitlist to be coached on the show. Get on the list to be notified about the upcoming certification program for coaches.