Podcasts about Coagulation

1er épisode / 5, de la série sur la maladie de Willebrand. Episode 1 : Maladie rare – Qu'appelle-t-on maladie de Willebrand ? Invitée : Pr Sophie Susen, chef de l'Institut d'hématologie et de transfusion du CHU de Lille, coordinatrice de la filière MHEMO, filière des maladies rares de l'hémostase, et du centre de référence coordonnateur de la maladie de Willebrand, qui ont contribué au PNDS sur la maladie de Willebrand. https://biologiepathologie.chu-lille.fr/instituthematologie/ https://mhemo.fr/    1️⃣   Qu'appelle-t-on maladie de Willebrand ? [0'32 – 2'31] ✔️ Déficit quantitatif ou qualitatif du facteur Willebrand, essentiel pour la coagulation sanguine. ✔️ Trois types principaux : I (déficit modéré), II (déficit fonctionnel) et III (déficit complet). ✔️ Elle touche environ 1 personne sur 1 000, les formes symptomatiques nécessitant un traitement sont plus rares, environ 1 personne sur 10 000. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Quelle est la physiopathologie de cette maladie rare ? [2'32 – 3'42] ✔️ Anomalie génétique du gène du facteur Willebrand. ✔️La maladie se révèle par des saignements, à différents âges et dans diverses situations (saignements muqueux, postopératoires). ✔️ Le type III se manifeste dès l'enfance avec des saignements graves. 3️⃣   Quel tableau clinique doit faire suspecter la maladie de Willebrand ? [2'43 -4'59] ✔️ Saignements variés (muqueux, ORL, gynécologiques, gastro-intestinaux) et articulaires (formes graves). ✔️ Circonstances de découverte : symptômes de saignements, bilan de coagulation préopératoire, antécédents familiaux. 4️⃣   Quelle est l'utilité d'établir un score hémorragique pour les patients concernés ? [4'59 – 6'21] ✔️ Permet d'objectiver la fréquence des saignements, justifie une exploration approfondie et la recherche de la maladie de Willebrand. 5️⃣   À qui adresser les patients en cas de suspicion de la maladie de Willebrand ? [6'22 – 7'26] ✔️Orientation vers un centre de référence pour un diagnostic précis et une prise en charge adaptée.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom ******************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu :

This conversation kicks off a new series that takes a deep dive into anything blood-related. During this episode, Dr. Andrew Jenzer revisits the podcast alongside Dr. Maxwell Lloyd to demystify some of the key ideas underpinning hemostasis, coagulation, and PTT levels. Join us as we discuss helpful tools to navigate detection, monitoring, testing, and all the factors that may affect results. From PTT and D-Dimer testing to mixed testing options and thrombal elastography, we cover it all. Next, we get into abnormalities and all the elements to consider before going about an invasive surgery of this nation. We get into detail about Von Willebrand's disease and what testing can tell you, after considering why clinical history is specifically important for the treatment of bleeding issues. Lastly, we discuss OMS-specific hemostatic agents, and the impact of CRASH 1, 2, and 3 trials on how we implement TXA. Join us today to hear all this and more. Key Points From This Episode:Introducing Drs. Andrew Jenzer and Maxwell Lloyd.Dr. Jenzer's upcoming mock boards course for residents.The topic of this episode which kicks off a new series: blood and anything blood related.Differentiating between primary and secondary hemostasis. Understanding intrinsic and extrinsic pathways. Why all coagulation factors are ultimately made in the liver.The importance of interpreting the lab values.Using the WETT acronym in the context of anti-coagulation.Monitoring through PTT. D-Dimer testing and why it is so often misunderstood. What is essential to do when mixing tests together. Another test option: thrombal elastography.Thinking about the risks and benefits of stopping anticoagulation. Developing a schema to think about abnormalities. Understanding how to address Haemophilia A and B. Why clinical history is particularly important for bleeding issues.Demystifying Von Willebrand's disease and what testing can tell you. OMS-specific hemostatic agents, which ones work best, and more. CRASH 1, 2 and 3 trials and TXA. Links Mentioned in Today's Episode:Dr. Maxwell Lloyd on Google Scholar — https://scholar.google.com/citations?user=D0agka0AAAAJ Dr. Andrew Jenzer Email — andrew.jenzer@gmail.com Dr. Andrew Jenzer — https://surgery.duke.edu/profile/andrew-clark-jenzer CRASH-1 — https://pmc.ncbi.nlm.nih.gov/articles/PMC33506/ CRASH-2 — https://pmc.ncbi.nlm.nih.gov/articles/PMC4576020/ CRASH-3 — https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext Everyday Oral Surgery Website — https://www.everydayoralsurgery.com/ Everyday Oral Surgery on Instagram — https://www.instagram.com/everydayoralsurgery/ Everyday Oral Surgery on Facebook — https://www.facebook.com/EverydayOralSurgery/ Dr. Grant Stucki Email — grantstucki@gmail.com Dr. Grant Stucki Phone — 720-441-6059

In this episode, we're going to explore the transformative role of Thromboelastography (TEG) in blood coagulation and transfusion therapy. This groundbreaking technology has revolutionized how we understand and manage blood coagulation. Here's some of what we discuss in this episode: TEG provides a detailed picture of what the patient's coagulation status is. How coagulation and traditional tests of coagulation work. Understanding these pathways and their associated tests is crucial for diagnosing and managing bleeding disorders. What are some common treatments for preoperative anemia? Risks and costs associated with transfusion therapy.   Visit us online: https://beyondthemaskpodcast.com/ The 1099 CRNA Institute: https://aana.com/1099 Get the CE Certificate here: https://beyondthemaskpodcast.com/wp-content/uploads/2020/04/Beyond-the-Mask-CE-Cert-FILLABLE.pdf Help us grow by leaving a review: https://podcasts.apple.com/us/podcast/beyond-the-mask-innovation-opportunities-for-crnas/id1440309246 Donate to Our Heart Your Hands here: https://www.ourheartsyourhands.org/donate  Support Team Emma Kate: https://grouprev.com/haloswalk2024-shannon-shannon-brekken

For more information, visit https://thecirsgroup.com Let this be your guide to the first annual CIRS Summit! CIRS, or Chronic Inflammatory Response Syndrome, is a complex illness, so there is a ton to learn about it as you receive your diagnosis and navigate the Shoemaker protocol to heal. Jacie and Barbara joined the steering committee to plan and produce this FREE event, the first of its kind that is geared towards patients. We break down the talks and point out our favorites, so we hope this helps you decide which talks to catch during the next replay, or whether it might be worth purchasing the upgraded ticket for access to replay at your convenience. All proceeds go towards important CIRS Research. To watch the CIRS Summit, visit https://the-ultimate-cirs-summit.heysummit.com/ For more information, support, and resources in your own CIRS healing journey, visit TheCIRSGroup.com TIME STAMPS: 0:00 Intro, disclaimer, and where you can watch The CIRS Summit 5:30 Introduction to Chronic Inflammatory Response Syndrome by Jacie Gregory 6:10 Staying Healthy Post-Protocol: Managing Re-Exposures: Dr. Christian Navarro-Torres, Jenny Johnson PT, FMCHC, NBC-HWC, Jacie Gregory & Barbara Williams 7:18 Building-Related Biotoxins: Mold, Bacteria and More by Larry Schwartz 7:30 Envirobiomics: Because Health Matters: Dust Testing and Blood Panel for CIRS by Gianni Rosinni 7:55 An Inconvenient Truth: Tick Borne Infections in CIRS Patients by Dr. Margaret DiTulio DNP, APRN 8:28 The Science Behind Brain Injury and Repair by Dr. Ritchie Shoemaker 9:10 Surviving Hypersensitivity in CIRS by Dr. Christian Navarro-Torres 9:54 Mindfully Navigating CIRS Recovery with Meditation by Melanie Joy Pensak M.S. CCC-SLP, CMT-P 10:28 The Devil is in the Differential: Diagnosing Chronic Illness by Dr. Margaret DiTulio DNP, APRN 10:35 Air Oasis: Love the Air you Breathe by Jon Bennert 10:40 Processing Grief: An Essential Step to Healing by Melanie Joy Pensak M.S. CCC-SLP, CMT-P, Dr. Lauren Sparks, Brenda Stewart LPC, LMHC, CTH & Mindy Mastruserio MS, NCC, LPC, CCTP-II 11:26 Understanding Red Hot Hands and Feet: Erythromelalgia in CIRS by Dr. Lauren Sparks 11:33 Common Remediation Mistakes and How to Avoid Them by Bill Weber 12:02 Leaky Buildings, Leaky Gut by Dr. Kellyn Milani NMD 12:07 CIRS: A Trauma-Based Illness by Dr. Andrew Heyman 12:10 Unlocking the Power of Genie to Inform your Recovery from CIRS by Louise Carder 12:50 The Importance of the HLA: Genetic Susceptibility to CIRS by Dr. Scott McMahon 13:11 The Importance of Family Support by Kendrah Betz & Matthew Betz 13:22 CIRS & Hormones by Dr. Anjali Noble 13:57 Eradicating MARCoNS by Dr. Joseph Mustom 14:08 Fixing Your Cells and Brain with Plasmalogens by Dr. Dayan Goodenowe 14:49 The Use of Peptides Beyond VIP by Dr. Christian Navarro-Torres 15:08 CIRS, Dysautonomia and Upper Cervical Care by Dr. Andrea Jordheim 16:10 Navigating Disordered Eating and CIRS by Brenda Stewart LPC, LMHC, CTH 16:30 Microbiology DX: Ordering and Understanding Marcons testing by Dr. Joseph Musto 17:16 PD Labs: Patient Driven Healthcare Solutions by Ray Solano 17:30 A Unique Way To Treat CIRS & Lyme by Dr. Laura Varga 17:40 Long Covid & CIRS by Jacie Gregory 18:09 Breathwork for the Moldy Brain by Morgan Glodowski 18:29 Deciphering the Alphabet Soup: CIRS Lab Tests and Reference Ranges by Dr. Ming Dooley 19:04 A Medically Important Professional Home Inspection for a CIRS Person by John Banta 20:06 Dietary Considerations for CIRS by Julia Davies 20:37 Setting Yourself Up for Success on the Shoemaker Protocol by Dr. Eric Dorninger 21:05 Navigating Project Pitfalls and Unlocking New Methods And Solutions by Brandon Apple 22:25 Healing from CIRS Outside the US by Louise Carder, Dr. Jodie Dashore, Mark Volmer & Kate Barry PhD 23:42 The Pain That No One Discusses: Suicidal Thoughts in CIRS by Mindy Mastruserio MS, NCC, LPC, CCTP-II 24:54 Minimizing the Financial Burden of CIRS Care by Alan Gruning DO 25:11 Coagulation & CIRS by Dr. James Ryan 25:35 Testing and Treating Bacterial Endotoxins in our Environment by Michael Schrantz, CIEC 26:39 Chasing the Ghosts of Water Damages Past by Greg Weatherman 27:11 Navigating Workplace Accommodations by Jane Prescot 27:40 How to Remediate and Maintain a Healthy Car by Mike Susi 29:00 Autoimmune illnesses and CIRS by Dr Miles Nichols 29:42 Assessing Your Own Home for Water Damage by Kendra Seymour 30:06 The Impact of Medical Trauma for CIRS Patients by Dr. Lauren Sparks 30:24 The Role of Clotting Disorders, Biofilm, and Actinobacteria in CIRS by Dr. Jacki Meinhardt 30:39 MoldCo: Online, Affordable Mold Illness Care and Treatments by Ariana Thacker 30:55 Putting it All Together: Patient Takeaways from The CIRS Summit by Jenny Johnson PT, FMCHC, NBC-HWC HELPFUL LINKS: Sign up for The CIRS Summit! https://the-ultimate-cirs-summit.heysummit.com/ CIRSx talks (free!): https://www.cirsx.com/conference-archives/ CIRSx courses: https://institute.cirsx.com/ The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Pre-order Jacie's book! https://a.co/d/8ZKCqz0 Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

Watch the full episode with Sarah Elkhaldy here: https://youtu.be/GsbVnuXjPfUSTAY INSPIRED & KEEP EVOLVINGYEWSupport this show http://supporter.acast.com/inspiredevolution. Hosted on Acast. See acast.com/privacy for more information.

Watch the full episode with Sarah Elkhaldy here: https://youtu.be/GsbVnuXjPfUSTAY INSPIRED & KEEP EVOLVINGYEWSupport this show http://supporter.acast.com/inspiredevolution. Hosted on Acast. See acast.com/privacy for more information.

Why You Should Listen:  In this episode, you will learn about the important role of hypercoagulation in chronic illness.  About My Guest: My guest for this episode is Ruth Kriz.  Utilizing her functional medicine background as well as experience in microbiology and teaching pharmacology, Ruth Kriz, MSN, APRN has spent the majority of her professional career as a Nurse Practitioner working with Chronic UTI and Interstitial Cystitis patients; as well as those dealing with hypercoagulation.  Her practice expanded to patients from almost all the states in the US as well as from 35 countries who came to her seeking answers beyond symptom management.  Through molecular testing, an understanding of the genetics common to these patients, and an understanding of how genetics contributes to chronic infection, hypercoagulation, and biofilms, she has been able to very successfully treat this population.  These factors have broad implications for other chronic infections (sinus, prostate, ear infections, wounds, etc.) as well as fibromyalgia, cardiovascular disease, and other conditions in which hypercoagulation and biofilms are an important contributor.  She has closed her medical practice, but she reinvented as a consultant to help practitioners learn how to utilize her approach for curing these patients and currently is working with MicroGenDX. Key Takeaways: What are the symptoms and conditions associated with hypercoagulation? Why is the "fibrinolytic pathway" a better term than "hypercoagulation"? What genetic predispositions are involved in coagulation disorders? Can hypercoagulation be treated naturally or are pharmaceutical interventions required? What is the role of vitamin K in coagulation? How might long-term antibiotics for chronic Lyme disease contribute to coagulation issues? What is the difference between fibrin and a biofilm? What are some of they key labs to explore in order to assess for the potential of hypercoagulation? Are statin drugs contraindicated in those with high Lp(a)? What role do platelets play in the coagulation discussion? What is the connection between long COVID and biofilms? How does lumbrokinase compare to nattokinase? Why are D-Dimer and PT/PTT not ideal tests for exploring hypercoagulation? Connect With My Guest:  http://RuthKriz.com Related Resources: To review additional resources mentioned in the episode, visit https://BetterHealthGuy.com/Episode207. Interview Date: October 29, 2024 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode207. Additional Information: To learn more, visit https://BetterHealthGuy.com. Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

1er épisode / 5, de la série sur le purpura thrombopénique immunologique (PTI). Episode 1 : Maladie rare - Qu'appelle-t-on PTI ? Invité : Pr Bertrand Godeau, médecin interniste, praticien hospitalier au sein du service de médecine interne de l'hôpital Henri Mondor à Créteil, coordinateur de l'actualisation du PNDS sur le PTI de l'adulte, médecin coordonnateur du centre de référence CeReCAI, affilié à la filière MaRIH. https://www.aphp.fr/service/service-54-026    https://marih.fr/groupe-experts/cerecai-centre-de-reference-des-cytopenies-auto-immunes-de-ladulte/    1️⃣   Qu'appelle-t-on purpura thrombopénique immunologique (PTI) ? [0'37 – 1'56] ✔️ Maladie auto-immune, avec production d'anticorps anti-plaquettes et leurs précurseurs (mégacaryocytes), ✔️ Maladie rare mais responsable de 4000 hospitalisations par an. ✔️ Sujets touchés de tout âge. Age moyen de diagnostic 50 ans. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/le-purpura-thrombopenique-immunologique-pti/ 2️⃣   Quel est le tableau clinique rencontré chez les patients touchés par un PTI ? [1'57 – 3'37] ✔️ Risque de saignements : cutanées, des muqueuses (gencives, nez),   ✔️ Les saignements graves sont rares (

In this episode of The One Thing Podcast, hosted by Dr. Adam Rinde, the focus is on integrative and naturopathic medicine, specifically addressing complex chronic illnesses and cancer care. Dr. Rinde introduces the guest, Dr. Paul Anderson, a leading voice in the field with over 30 years of clinical experience. The episode aims to explore the topic of coagulopathy in chronic disease, discussing its mechanisms, implications, and potential treatments. Guest Highlights • Dr. Paul Anderson: o Leading voice in integrative and naturopathic medicine. o Specializes in complex chronic illness and cancer care. o Over 30 years of clinical experience. o Led the interventional arm of a US NIH-funded human research trial on IV and integrative therapies for cancer patients. o Founder of Advanced Medical Therapies in Seattle, Washington. o Collaborates with clinics and hospitals worldwide. o Academic contributions include serving as a professor of pharmacology and clinical medicine and as the chief of IV Services for Baer's Oncology Research Center. o Published works include "Outside the Box Cancer Therapies" and "Cancer, the Journey for Diagnosis to Empowerment." o Notable work on intravenous nutrient therapy featured in a scientific reference textbook. Main Topics Covered 1. Mechanisms of Coagulation: o Discussion on the intrinsic and extrinsic pathways of coagulation. o Role of immune chemicals in triggering clotting. o Impact of chronic illnesses and infections like COVID-19 on coagulation. 2. Coagulopathy in Chronic Disease: o Excessive coagulation in chronic disease states. o Specific conditions discussed include COVID-19, fibromyalgia, chronic fatigue syndrome, and POTS (postural orthostatic tachycardia syndrome). o How coagulopathies may hinder patient recovery and the importance of assessing and addressing these issues. 3. Genetic and Environmental Factors: o Influence of genetics on susceptibility to hypercoagulability. o Role of diet, hydration, and lifestyle in managing coagulation issues. o Importance of testing and early detection for prevention and treatment. 4. Treatment Approaches: o Use of supplements like vitamin E, omega oils, and fibrinolytic enzymes (e.g., nattokinase, lumbrokinase). o Potential use of baby aspirin for managing clotting issues. o Importance of a stepwise approach to treatment, starting with lifestyle modifications and progressing to more intensive interventions if necessary. 5. Biofilm and Chronic Infections: o Connection between biofilm formation and chronic infections. o How pathogens use fibrin to form protective biofilms, complicating treatment. o Strategies for breaking down biofilms to improve patient outcomes. 6. Hope and Recovery: o Emphasis on the possibility of recovery from chronic illnesses and coagulopathies. o Importance of finding a supportive healthcare team and utilizing available resources for treatment and management Related Links 1. Dr. Paul Anderson's Books: o "Outside the Box Cancer Therapies" by Dr. Paul Anderson and Dr. Mark Stengler o "Cancer, the Journey from Diagnosis to Empowerment" by Dr. Paul Anderson 2. Research on Coagulation and COVID-19: o Studies on interleukin-6 and its role in COVID-19 o Research on microclots in COVID-19 patients 3. Supplements Mentioned: o Nattokinase o Lumbrokinase o Baby aspirin o Vitamin E o Omega oils 4. Organizations and Labs: o Fry Laboratories (historical reference) 5. Conditions Discussed: o COVID-19 and Long COVID Socials Mentioned: • Social Media Handles: o Twitter: @DrAConsult o LinkedIn: Dr. Paul Anderson • Website: ConsultDrAnderson.com --- Support this podcast: https://podcasters.spotify.com/pod/show/onethingpod/support

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary Chapter 3.5 Penicillins  Chapter 3.5 of the Nursing Pharmacology guide focuses on penicillins, detailing their discovery, mechanism of action, indications, administration considerations, potential side effects, and patient education. Penicillins work by interfering with bacterial cell wall synthesis, and they treat infections like Streptococcal and Staphylococcal. Nurses should monitor for allergic reactions, superinfections, and drug interactions. Proper patient teaching includes medication adherence and monitoring symptoms. Multiple Choice Questions What is the primary mechanism of action for penicillins? a) Blocking protein synthesis b) Disrupting cell wall synthesis c) Inhibiting DNA replication d) Preventing RNA transcription Which condition is penicillin commonly used to treat? a) Hypertension b) Streptococcal infections c) Diabetes d) Migraine headaches What is a common side effect of high doses of penicillin? a) Hyperglycemia b) Coagulation abnormalities c) Increased heart rate d) Dry skin Why should patients avoid taking penicillin with citrus-based products? a) It increases absorption b) It reduces absorption c) It causes stomach pain d) It increases side effects What should a patient do if they develop diarrhea while taking penicillin? a) Stop taking the medication immediately b) Treat it with over-the-counter medicine c) Contact their healthcare provider d) Drink more fluids Answer Key b) Disrupting cell wall synthesis b) Streptococcal infections b) Coagulation abnormalities b) It reduces absorption c) Contact their healthcare provider ```

Why You Should Listen:  In this episode, you will learn about the use of GENIE testing in Chronic Inflammatory Response Syndrome. About My Guest: My guest for this episode is Dr. Ritchie Shoemaker.  Ritchie Shoemaker, MD is a recognized leader in patient care, research, and an education pioneer in the field of biotoxin related illness.  While illness acquired following exposure to the interior environment of water-damaged buildings (WDB) comprises the bulk of Dr. Shoemaker's daily practice, other illnesses caused by exposure to biologically-produced toxins are quite similar in their “final common pathway.”  What this means is that while the illness might begin acutely with exposure to fungi, spirochetes, apicomplexans, dinoflagellates and cyanobacteria, for example, in its chronic form, each of these illnesses has similar symptoms, lab findings, and Visual Contrast Sensitivity (VCS) findings.  Taken together the inflammatory illness from each of these diverse sources is known as  Chronic Inflammatory Response Syndrome. Key Takeaways: What is GENIE? Is HLA-DR still relevant? What are the common triggers of CIRS?  Actinobacteria?  Endotoxins?  Mold and mycotoxins? What is hypometabolism? How does CIRS impact insulin and blood sugar? What is apoptosis? What is the role of coagulation in CIRS? Are upregulated cytokines seen in CIRS? Can GENIE identify those that may have Lyme? What are defensins? What is Ikaros? What is the role of MAP kinases in CIRS? What do Toll receptors tell us? How are B and T cells involved in CIRS? How many CIRS markers are needed in GENIE to suggest CIRS? What is the PTSD gene? How often is histamine involved? What are the cytoskeleton and microtubules?  What can be determined around the function of Treg cells? What are the recent additions to GENIE in the realm of Parkinson's disease? What has GENIE told us about MARCoNS? Connect With My Guest:  http://SurvivingMold.com Interview Date: September 11, 2024 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode205. Additional Information: To learn more, visit https://BetterHealthGuy.com. Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

Learn to coagulate your life.

IntroductionWelcome to PICU Doc On Call, a podcast dedicated to current and aspiring pediatric intensivists. I'm Dr. Pradip Kamat from Children's Healthcare of Atlanta/Emory University School of Medicine, and I'm Dr. Rahul Damania from Cleveland Clinic Children's Hospital. We are two Pediatric ICU physicians passionate about medical education in the PICU. This podcast focuses on interesting PICU cases and their management in the acute care pediatric setting.Episode OverviewIn today's episode, we are excited to welcome Dr. Karen Zimowski, Assistant Professor of Pediatrics at Emory University School of Medicine and a practicing pediatric hematologist at Children's Healthcare of Atlanta at the Aflac Blood & Cancer Center. Dr. Zimowski specializes in pediatric bleeding and clotting disorders.Case PresentationA 16-year-old female with a complex medical history, including autoimmune thyroiditis and prior cerebral infarcts, was admitted to the PICU with acute chest pain and difficulty breathing. Despite being on low-dose aspirin, her oxygen saturation was 86% on room air. A CT angiography revealed a pulmonary embolism (PE) in the left lower lobe and signs of right heart strain. The patient was hemodynamically stable, and thrombolytic therapy was deferred in favor of anticoagulation. She was placed on BiPAP to improve her respiratory status. Her social history was negative for smoking, illicit drug use, or oral contraceptive use.Key Case PointsDiagnosis: Pulmonary embolism (PE)Hemodynamics: Stable with no right ventricular (RV) strain on echocardiogramManagement Focus: Anticoagulation and consultation with the hematology/thrombosis teamExpert Discussion with Dr. Karen ZimowskiRisk Factors and Epidemiology of VTE in PediatricsPathophysiology: Venous thromboembolism (VTE) in children involves components of Virchow's triad: stasis of blood flow, endothelial injury, and hypercoagulability.Incidence: VTE is rare in the general pediatric population but increases significantly in hospitalized children.Age Distribution: Bimodal peaks in infants and adolescents aged 15-17 years.Risk Factors: Central venous lines, infections, congenital heart disease, cancer, and autoimmune disorders.Clinical Manifestations of DVTSymptoms: Swelling, pain, warmth, and skin discoloration in the affected extremity.Specific Presentations:SVC syndrome from superior vena cava thrombosisAbdominal pain from portal vein thrombosisHematuria from renal vein thrombosisNeurological symptoms...

Why You Should Listen:  In this episode, you will learn about a toolkit to improve cognition and protect brain health from cognitive decline. About My Guest: My guest for this episode is Dr. Heather Sandison.  Heather Sandison, ND is a renowned naturopathic doctor specializing in neurocognitive medicine and the founder of Solcere Health Clinic, San Diego's premier brain optimization clinic, and Marama, the first residential memory care facility to have the goal of memory recovery.  She has dedicated her career to supporting those suffering with dementia and is the primary author of the peer reviewed research “Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline” published in the Journal of Alzheimer's Disease.  Dr. Sandison hosts the annual online Reverse Alzheimer's summit where she shares cutting-edge and tried-and-true insight into what is possible for those suffering with dementia.  She is excited to shatter common misconceptions about Alzheimer's and share what she has learned about keeping your brain sharp at any age.  She is also the author of the newly released book “Reversing Alzheimer's The New Toolkit to Improve Cognition and Protect Brain Health”. Key Takeaways: What are the most common factors impacting cognitive health today? What are some of the top tools for mitigating environmental toxicity? What approaches lead to optimal microbiome diversity? What is the role of herpetic viruses in Alzheimer's? How much more important has vascular health become in the pandemic era? What are the genetic contributors to cognitive decline? Is the presence of amyloid correlation or causation? How can one more consistently remain in ketosis without dependence on exogenous ketones? Should certain people avoid saturated fats? What are some of the tools that may assist in balancing lipid dysregulation? Is there a place for limbic and vagal work in optimizing cognitive health? What are some of the common challenges preventing optimal sleep? Are all seed oils toxic? Can vegetarians and vegans optimize cognitive health without animal protein? What is the role of hypercoagulation and arterial calcification in cognitive decline? How important is reducing EMFs in reversing Alzheimer's? How can mitochondrial health be supported to optimize energy currency production? Can antimicrobial mouthwashes actually make things worse? What is the role of peptides in supporting brain health? Connect With My Guest:  http://ReversingAlzheimersBook.com Interview Date: June 18, 2024 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode202. Additional Information: To learn more, visit https://BetterHealthGuy.com. Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

Why do patients with long COVID have such a wide array of symptoms affecting so many bodily systems? That bedeviling question is the focus of this episode of Raise the Line featuring Dr. Resia Pretorius, head of the Department of Physiological Sciences at Stellenbosch University in South Africa and a renowned researcher in coagulation. “The underlying concept of what is happening, in our minds, is that long COVID is a widespread vascular endotheliitis, which is driven by the presence of all sorts of inflammatory molecules in circulation,” she tells host Dr. Raven Baxter of the Cohen Center for Recovery from Complex Chronic Illnesses (CoRE). Because endothelial cells line blood vessels that travel to every part of the body, their impairment produces a range of symptoms. Dr. Pretorius and her research colleagues have discovered that “microclots” – abnormal proteins that prevent clots from breaking down – are another ingredient in the long COVID recipe due to their possible role in reducing oxygen flow to the brain and other organs. Because of their unusual structure, microclots are not detected by customary blood tests, leading Dr. Pretorius to add her voice to the chorus of stakeholders calling for the development of new diagnostic tests and additional treatments. “We need a concerted effort for trials. We need FDA approval for the laboratory test that we developed. I'm confident we will get it done, but it will take time, which is sad.” Tune in to learn about the possible causes of microclots, promising research on anticoagulation therapy and why long COVID is not a “checklist” disease, as our special series on post-acute infection syndromes continues. Mentioned in this episode:Mount Sinai Health SystemSteven & Alexandra Cohen Foundation

Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. In today's episode, Karine Carrière  will explain further what are microvesicles, their importance in coagulation and how to analyze them.  Literature sources: [Tesselaar et al.], [Lacroix et al.] [Faille et al.] [Mullier et al.] Vallier et al.] . [Nieuwland et al.] Kim HK, Song KS, Park YS, Kang YH, Lw YJ, Lw KR, et al. Elevated levels of circulating platelet microparticles, VEGF, 11-6 and FiANTES in patients Wlth gastrlc cancer. possible mle of a metastasis predlotor. Eur J Cancer 2003;39(2):184-91. Helley D, Banu E, Bouziane A, Banu A, Scotte F, Fiher AM, et al. Platelet microparticles: a potential predictive factor of survival in hormone-reac pmstate cancer patients treated with docetaxel-based chemotherapy. Eur Urnl2009;56(3):479-84. Zwicker JI, Liebman HA, Neuberg D, Lecmix R, Bauer KA, Furie BC, et ai. Tmr-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res 2009; 15 (22): 68630-40   Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

CME credits: 0.25 Valid until: 30-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/evolving-our-view-of-the-coagulation-cascade-and-stroke-management/24144/ How can you improve long-term secondary stroke prevention in patients with a history of noncardioembolic ischemic stroke or transient ischemic attack (TIA)? An understanding of how to apply emerging clinical trial data is critical, as is the evaluation of potential alternative agents that could expand the therapeutic options for these patients. In this activity, our expert faculty will add to your knowledge by reviewing the coagulation cascade and the relevance of inhibiting factors XI and XIa in stroke management.=

FREE! CRNA School Interview Prep Guide: https://www.cspaedu.com/uc9a5ih4There's an entire coagulation cascade going on in your blood vessels that is protecting you from bleeding to death. It's complex process, and it's easy to get lost in the intricacies of the mechanism. Lucky for us, Dr. Stephanie Woodruff, Program Director at Ursuline College Nurse Anesthesia Program joins us in this episode to give us an easier way to memorize how the coagulation cascade works. Stephanie Woodruff, DNP, CRNA, CHSENurse Anesthesia Program Director (NAPD)Associate ProfessorDr. Woodruff serves as the Program Director of SNAP. She graduated from Georgetown University in 1994 with a bachelor's in nursing. In 1998, she received her master's in nursing from the University of Pennsylvania and was certified as a Nurse Practitioner in Women's Healthcare. Dr. Woodruff became a Certified Registered Nurse Anesthetist in 2008 after graduating with her second master's degree from the University of Pennsylvania. In 2017, she received her DNP from Wilmington University. She is the State Peer Advisor for Pennsylvania through the AANA and is a member of the Pennsylvania Association of Nurse Anesthetist Wellness Committee. Dr. Woodruff continues to practice clinically once a week.Get your note-taking tools and tune in!Fast-Track Your CRNA Interview Prep with our CRNA Interview Crash Course! https://www.cspaedu.com/4wotmldsHave you gained acceptance to CRNA school? Congratulations! Prepare with the #1 pre-anesthesia curriculum, as recommended by CRNA program faculty. Start the NAR Boot Camp today: https://www.cspaedu.com/bootcampThousands of nurses have gained CRNA school acceptance with CRNA School Prep Academy. Join today for access to all of the tools proven to accelerate your CRNA success! Click here: https://cspaedu.com/joinJoin the CSPA email list: https://www.cspaedu.com/podcast-emailJoin the Free Facebook Community here! https://www.facebook.com/groups/crnaschoolprepacademyfreeBook a mock interview, resume or personal statement critique, transcript review and more: www.teachrn.com

The topic of discussion for this episode leans more toward the scientific side but has huge clinical relevance. For today, we will be asking our expert panel to lend their experience and expertise to the topic of FVIII and FIX, which we will be discussing from several related perspectives.    Contributors: Radek Kaczmarek, PhD, MSc; University of Indiana, USA Peter Lenting, PhD; INSERM, Paris, France Ben Samuelson -Jones, M.D., PhD; CHOP Research Institute, USA Courtney Thornburg, M.D., MS; Rady Children's Hospital, UCSD, USA   Senior Advisor: Donna DiMichele, MD   Hosted & Written by: Patrick James Lynch   Featured Advertiser: Sanofi   Subscribe to the Global Hemophilia Report   Show Notes: Presenting Sponsor: Sanofi   Subscribe to the Global Hemophilia Report   Connect with the Global Hemophilia Report Global Hemophilia Report on LinkedIn Global Hemophilia Report on Twitter Global Hemophilia Report on Facebook   Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter

Hello everyone, today Dr. May and Verity discuss a clinical case out of BSAVA Companion Journal, going through case history, differentials, discussing several topics from jaundice, to coagulation cascade, anaemia and more! *this is not a sponsored ad, but we recommend getting the BSAVA membership as a small animal vet or vet student because of all the valuable resources you get access to! A good refresher or introduction to how we can practice our approach to cases, and this is based off the 'Clinical Conundrum' section in the BSAVA Companion Journal so all credit goes to the author, Alice Elischer, referenced below. We hope you find this entertaining or useful, and please let us know in the comments or on socials if you'd like more episodes like these. References 1. BSAVA Companion, Volume 2023, Issue 7, Jul 2023, p. 4 - 7 https://doi.org/10.22233/20412495.0723.4 2. Coagulation assays https://eclinpath.com/hemostasis/tests/screening-coagulation-assays/

In this week's episode we'll discuss the findings from a two-year follow-up study of lisocabtagene maraleucel in relapsed or refractory large B-cell lymphoma, learn more about how reciprocal stabilization of coagulation factor XIII-A and -B subunits influences plasma FXIII concentration, and discuss the findings from a phase 2 study of inotuzumab ozogamicin for measurable residual disease in acute lymphoblastic leukemia in remission.

This holiday week is a big astrological week as we experience the forward movement of Chiron and Jupiter. A bright Full Moon in Cancer happens on Tuesday as we sift through our year end emotions. The party starts later in the week as Venus enters Jupiter's domain while Jupiter stations direct in Venus's domain. All this week on The Golden Astrologer Podcast!

In this week's episode we delve into the world of cardiac catheterization and speak with Assistant Professor of Pediatrics at USC, Dr. Neil Patel about a recent work he co-authored at Children's LA about continuation of anti-coagulation during catheterization. Does AC have to be stopped to safely perform a catheterization? Are there certain cases or patients in whom the risk may be especially high? What about NOACs or DOACs? When should closure devices be considered? These are amongst the questions posed to Dr. Patel this week.DOI: 10.1007/s00246-023-03097-x

This week on the show, my good friend, colleague, and fellow alchemist Martin Ferretti comes back on to get real deep into the stages of alchemy throughout all processes of life. Despite his show The Alchemical Mind being on hiatus for some time, Martin has been a diligent alchemist in many capacities for years now, and he's one of my favorite people to talk to when it comes to this subject. Calcination, Dissolution, Separation, Conjunction, Fermentation, Distillation, and Coagulation -- these are the seven stages of alchemy, whether it be mental, physical, or spiritual. In seven stages we even find the levels of heaven and hell, the seven chakras, concepts like the seven stages of grief, and so much more. What does it mean to go through these processes on a psychological, existential level? To further elaborate this food for thought we bring up topics like Carl Jung, shadow work, the Kabbalah, Aristotle's distaste for the written word, Philip K Dick, Liu Cixin's The Three Body Problem, dark timelines and my recent conversation with Eric Millar, deciphering psychedelic revelations, and so much more. We hope you dig it! This week's featured music! Don't forget to support your favorite artists and all that black hoodie metal and hardcore! Rigor Mortis - Darkroom Original Spirit - Negative Blast Rats - Salt Psychic Trash - Negative Blast Starcrusher - Doc Hammer --- Send in a voice message: https://podcasters.spotify.com/pod/show/blackhoodiealchemy/message Support this podcast: https://podcasters.spotify.com/pod/show/blackhoodiealchemy/support

In this episode of “Lab Medicine Rounds,” host Justin Kreuter, M.D., speaks with Jansen Seheult, M.B., B.Ch., B.A.O., M.D., assistant professor of laboratory medicine and pathology in the Division of Hematopathology, to discuss heterophile antibodies and HIL, which are considered by some to be analytical errors and by others to reflect patient-related pre-analytical variables. Timestamps:00:00 Introduction00:40 Role of pre-analytical variables for coagulation testing03:25 Common pre-analytical variables to be aware of07:49 Medical community collaboration to mitigate patient-related issues11:51  Share about an intervention that was tried and how that worked out14:10 Future of coagulation testing16:34 Outro

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Coagulation Cascade⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠from the Heme section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

In this episode of “Lab Medicine Rounds,” guest host Ann Moyer, M.D., Ph.D., speaks with Justin Kreuter, M.D., transfusion medicine pathologist and assistant professor of pathology and laboratory medicine at Mayo Clinic, about common misunderstandings and practical ways to teach the basics of coagulation. Timestamps:0:00 Intro00:48 Why is it important for physicians to understand the fundamentals of coagulation?02:27 In your experience, what are a few of the common misunderstandings that people might have?08:15 Do you have any thoughts on what we can do better to teach a complicated topic like coagulation?13:57 Are there any sessions at the upcoming Bleeding and Thrombosing Diseases conference that you are looking forward to in particular?15:31 Outro

Commentary by Dr Eue-Keun Choi

STUDIES REFERENCE IN THE EPISODE   SWITCHING FROM TOFACITINIB TO BARICITINIB   Kazmi A et al (starts at 12:33). Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.     RITLECITINIB IN ADOLESCENTS   Hordinsky M et al (starts at 21:31). Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double-blind, placebo-controlled trial. Pediatr Dermatol. 2023 Jul 17.     RISK OF INFECTIONS, CANCER, HEART DISEASE AND BLOOD CLOTS IN AT/AU   George P et al (starts at 36:08). Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.     Schneeweiss MC et al (starts at 37:36). Incidence of Venous Thromboembolism in Patients With Dermatologist-Diagnosed Chronic Inflammatory Skin Diseases. JAMA Dermatol. 2021 Jul 1;157(7):805-816.     MARKERS OF VENOUS THROMBOEMBOLISM IN ALOPECIA AREATA   Sudnik W et al (starts at 57:40) . The role of selectins in alopecia areata. Postepy Dermatol Alergol. 2015 Feb;32(1):27-32.   Shakoei S et al (starts at 58:23). Coagulation status in patients with alopecia areata: a cross-sectional study. Ital J Dermatol Venerol. 2021 Oct;156(5):588-592.   Waśkiel-Burnat A et al (starts at 59:30). Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry about? Dermatol Ther (Heidelb). 2023 Aug;13(8):1847-1855.     HABIT REPLACEMENT THERAPY FOR TRICHOTILLOMANIA   Moritz S et al (starts at 1:04:34). Self-Help Habit Replacement in Individuals With Body-Focused Repetitive Behaviors: A Proof-of-Concept Randomized Clinical Trial.  JAMA Dermatol. 2023 Jul 19;e232167.   LINK TO VIDEO on HRT DEMONSTRATION https://clinical-neuropsychology.de/habit-replacement-en/#sthash.J6iQiYRi.dpuf    

For more information, visit https://thecirsgroup.com We attended CIRSx 2023 and learned a ton of new info and are bringing you the highlights today! We had to split up the whole CIRSx weekend into two parts, and here is part two! For more information, visit TheCIRSGroup.com   TIME STAMPS: 00:00 Intro 00:58 Even Holy Water Supports Mold - Mike Schrantz and Bill Weber 03:13 Erythromelalgia and Peripheral Hypoperfusion - Dr. Lysander Jim 04:04 Stop Coronary Disease: Live Longer, Live Better - Dr. Bill Blanchett 05:26 Dust Mites: So Uncontroversial It's Almost Forgotten - Carl Grimes 07:03 Cyanobacterial Toxins as a Risk Factor for Neurodegeneration - Dr. Elijah Stommel 08:18 Coagulation and GENIE - Dr. James Ryan 09:24 Foundations Training with Jesse Salas and Dr. Goodman  10:51 Understanding Immune Response Genetics: Deeper Dive into HLA - Dr. Scott McMahon 11:52 Historical vs Modern Dust - Greg Weatherman 12:35 Osteopathy as an Adjunct Therapy for Those with CIRS - Dr. April Vukelic 14:42 Holy Water Pt 2 - Mike Schrantz and Bill Weber 15:10 House Hunting with CIRS - Jennifer Schrantz 17:09 Benzo Induced Neurologic Dysfunction - Dr. Christy Huff 19:21 Outro CIRSx website: https://www.cirsx.com/2023-cirsx-annual-conference Jacie is a 3.5+ year carnivore, certified nutrition coach, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a coach, facilitator, speaker, 2.5+ year carnivore, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment. Catch Jacie and Barbara on Judy Cho's podcast to learn more about their health journeys and why they started The CIRS Group: When Carnivores are Affected by Mold Illness - Jacie Gregory & Barbara Williams - https://youtu.be/CR8Uj-d_fok

DrBeen#39 Is Nattokinase Protective Against SARS-COV-2? Nattokinase is thrombolytic, spike protein degradative, and anti-aging enzyme produced by Bacillus subtilis. Is it protective against SARS-COV-2? Let's take a look. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Dec. 19 2022 File:Natto mixed by Kinchan1.jpg - Wikimedia Commonshttps://commons.wikimedia.org/wiki/File:Natto_mixed_by_Kinchan1.jpg Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/#:~:text=Mechanism%20of%20Action.,activator%20(t%2DPA) Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458005/ A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles | Scientific Reportshttps://www.nature.com/articles/srep11601 Mechanism of Action. Nattokinase dissolves blood clots by directly... | Download Scientific Diagramhttps://www.researchgate.net/figure/Fig-2-Mechanism-of-Action-Nattokinase-dissolves-blood-clots-by-directly-hydrolyzing_fig2_321687198 Coagulation and fibrinolytic cascades. Ca, calcium; FDPs, fibrin... | Download Scientific Diagramhttps://www.researchgate.net/figure/Coagulation-and-fibrinolytic-cascades-Ca-calcium-FDPs-fibrin-degradation-product_fig2_284136686 Coagulation and anticoagulation in idiopathic pulmonary fibrosis | European Respiratory Societyhttps://err.ersjournals.com/content/24/137/392.figures-only Coagulation Clotting Mechanisms - Circulatory System - MCAT Contenthttps://jackwestin.com/resources/mcat-content/circulatory-system/coagulation-clotting-mechanisms Physiology, Coagulation Pathways - StatPearls - NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482253/#:~:text=The%20intrinsic%20pathway%20is%20activated,endothelial%20cells%20after%20external%20damage.&text=This%20pathway%20is%20the%20longer%20pathway%20of%20secondary%20hemostasis. Intrinsic Pathway of Coagulation and Thrombosis | Arteriosclerosis, Thrombosis, and Vascular Biologyhttps://www.ahajournals.org/doi/full/10.1161/ATVBAHA.118.312130 Plasmin - Wikipediahttps://en.wikipedia.org/wiki/Plasmin Urokinase - Wikipediahttps://en.wikipedia.org/wiki/Urokinase Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

DrBeen#38 Nattokinase Antithrombotic Mechanism of Action Nattokinase Part 1 of 3 (to be followed by Part 2: Nattokinase and The Degradation of the Spike Protein and Part 3: Nattokinase: Dosing and Safety) Nattokinase is a thrombolytic, spike protein degradative, and anti-aging enzyme produced by Bacillus subtilis. Nattokinase is made by fermenting soybeans with Bacillus subtilis. Let's review its actions. URL list from Monday, Dec. 19 2022 File:Natto mixed by Kinchan1.jpg - Wikimedia Commonshttps://commons.wikimedia.org/wiki/File:Natto_mixed_by_Kinchan1.jpg Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/#:~:text=Mechanism%20of%20Action.,activator%20(t%2DPA) Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458005/ A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles | Scientific Reportshttps://www.nature.com/articles/srep11601 Mechanism of Action. Nattokinase dissolves blood clots by directly... | Download Scientific Diagramhttps://www.researchgate.net/figure/Fig-2-Mechanism-of-Action-Nattokinase-dissolves-blood-clots-by-directly-hydrolyzing_fig2_321687198 Coagulation and fibrinolytic cascades. Ca, calcium; FDPs, fibrin... | Download Scientific Diagramhttps://www.researchgate.net/figure/Coagulation-and-fibrinolytic-cascades-Ca-calcium-FDPs-fibrin-degradation-product_fig2_284136686 Coagulation and anticoagulation in idiopathic pulmonary fibrosis | European Respiratory Societyhttps://err.ersjournals.com/content/24/137/392.figures-only Coagulation Clotting Mechanisms - Circulatory System - MCAT Contenthttps://jackwestin.com/resources/mcat-content/circulatory-system/coagulation-clotting-mechanisms Physiology, Coagulation Pathways - StatPearls - NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482253/#:~:text=The%20intrinsic%20pathway%20is%20activated,endothelial%20cells%20after%20external%20damage.&text=This%20pathway%20is%20the%20longer%20pathway%20of%20secondary%20hemostasis. Intrinsic Pathway of Coagulation and Thrombosis | Arteriosclerosis, Thrombosis, and Vascular Biologyhttps://www.ahajournals.org/doi/full/10.1161/ATVBAHA.118.312130 Plasmin - Wikipediahttps://en.wikipedia.org/wiki/Plasmin Urokinase - Wikipediahttps://en.wikipedia.org/wiki/Urokinase Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

On falling into existence by failing temptation.If you are wondering what happened to HIEROPHANY #14 then check out OEITH #204 (https://tinyurl.com/36nvukxy) on the topic of depressive hedonia and its antidote.Anonymous (2002). Meditations on the Tarot: A Journey into Christian Hermeticism. New York: Tarcher.Aleister Crowley (1929). Magick in Theory and Practice, https://tinyurl.com/msuku7bw (iarchive.com). Accessed May 2023.Baba Ram Dass (1979). Psychosis: A Framework for an Alternate Possibility. In: James Fadiman & Donald Kewman (eds.), Exploring Madness: Experience, Theory, and Research, second edition. Monterey, CA: Brooks/Cole.Patrick Harpur (2003). Daimonic Reality: A Field Guide to the Otherworld. Ravensdale, WA: Pine Winds.Support the podcast and access additional content at: https://patreon.com/oeith. Buy me a coffee at https://ko-fi.com/oeith or https://www.buymeacoffee.com/dbarfordG. Or you could send me a lovely book from https://www.amazon.co.uk/hz/wishlist/ls/1IQ3BVWY3L5L5?ref_=wl_share. Hosted on Acast. See acast.com/privacy for more information.

On our latest episode, Joe chats with Trevor Warmedahl, the 2022 Daphne Zepos Teaching Endowment Award winner. Trevor is known as the "Milk_Trekker" by his popular instagram and YouTube handle where he is followed by thousands. Trevor is a real life nomadic herdsman, cheese maker, writer, and educator who has traveled to remote areas of the world studying different coagulation and rennet practices while embracing regenerative grazing and sustainable livestock practices. We catch up to hear what he's been up to and where's he's been lately - don't miss this inspirational session!Photo courtesy of Alexander Pomper.Heritage Radio Network is a listener supported nonprofit podcast network. Support Cutting the Curd by becoming a member!Cutting the Curd is Powered by Simplecast.

In this week's episode we'll report on the findings from a 5-year follow-up study of axicabtagene ciloleucel in refractory large B-cell lymphoma, discuss the role of C1 inhibitor deficiency in coagulation and venous thrombosis, and learn how chemotherapy signatures can be used to track the evolution of therapy-related myeloid neoplasms.

Looking for more information on this topic? Check out the Disseminated Intravascular Coagulation brick. If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

À l'occasion de la journée mondiale de l'hémophilie, nous parlons des troubles de la coagulation. Quand il y a saignement, le corps met en place plusieurs mécanismes afin de colmater le vaisseau qui saigne : la contraction des vaisseaux sanguins, l'activation des plaquettes et la coagulation sanguine. Saignements anormaux, thromboses artérielles ou veineuses… Les troubles de la coagulation peuvent avoir différentes causes. Quelles sont-elles ? Comment dépister et traiter ces troubles ? Dr Laurent Frenzel, hématologue et rhumatologue, responsable du Centre de l'hémophilie à l'Hôpital Necker-Enfants Malades à Paris, hôpital jumelé avec le CHU Ignace Deen, de Conakry, en Guinée Dr Mamady Diakité, chef du service d'Hématologie du CHU de Conakry en Guinée. Enseignant-chercheur à la Faculté des Sciences et Techniques de la Santé à l'Université de Conakry. Témoignage par Raphaëlle Constant.

À l'occasion de la journée mondiale de l'hémophilie, nous parlons des troubles de la coagulation. Quand il y a saignement, le corps met en place plusieurs mécanismes afin de colmater le vaisseau qui saigne : la contraction des vaisseaux sanguins, l'activation des plaquettes et la coagulation sanguine. Saignements anormaux, thromboses artérielles ou veineuses… Les troubles de la coagulation peuvent avoir différentes causes. Quelles sont-elles ? Comment dépister et traiter ces troubles ? Dr Laurent Frenzel, hématologue et rhumatologue, responsable du Centre de l'hémophilie à l'Hôpital Necker-Enfants Malades à Paris, hôpital jumelé avec le CHU Ignace Deen, de Conakry, en Guinée Dr Mamady Diakité, chef du service d'Hématologie du CHU de Conakry en Guinée. Enseignant-chercheur à la Faculté des Sciences et Techniques de la Santé à l'Université de Conakry. Témoignage par Raphaëlle Constant.

In this episode, we review the high-yield topic of Coagulation Factor Inhibitor ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Hematology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

The following episode specifically focuses on the role of platelets in coagulation. This episode builds upon the previous episode, which focused on the clotting cascade, with a detailed discussion of the formation of the platelet plug and its unique interaction with the fibrin mesh produced by the clotting cascade. The stage is now set for a discussion of anticoagulants. 

Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. In this episode, to coincide with International Womens Day (March 8th), we are focusing on Gender equality in the workforce, why this is good for business and good for society overall. We meet with Eva Ohlsson Desormonts, Group HR Director for Stago and Amandine Serret International Business Support and Communications Director for Stago as well as an Executive Coach. Literature sources: Women in the Workpace 2022, McKinsey & Company whitepaper Challenges facing early career women in thrombosis and hemostasis—meeting the needs of the next generation, Guest Editorial, J Thromb Haemost. 2022;20:2453-5455   Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

Welcome to Ask Stago, the Podcast dedicated to provide expert answers to your expert questions in coagulation. In today's episode, we are delighted to speak to April Matera. April experienced a stroke at the age of 39 and from there began her journey towards an anti-phospholipid syndrome diagnosis. Unfortunately it took 7 different visits to 7 different doctors to get her there. She tells us here about her APS road and how it has impacted her life and her dream to have a family.   Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

In this episode, we review the high-yield topic of Disseminated Intravascular Coagulation (DIC) from the Heme section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

Join Ashley as she discusses coagulation disorders with Dr. Angela Shaw.

Dr. Marques received her M.D. from the Federal University of Rio Grande do Sul in Brazil and trained in Internal Medicine at the same institution. She and her husband moved to the United States in 1986.  She spent 2 years at NIH and 5 years at Harvard Medical School as a research fellow before coming to UAB to train in Pathology.  She has been a faculty member since 1998 in the Laboratory Medicine sections of Apheresis, Coagulation and Transfusion Medicine.  She has been very active in national societies having been an ASFA Board member for 8 years and President from 2014-2015, as well as President of the Academy of Clinical Laboratory Physicians and Scientists (ACLPS) from 2016-2017.  She loves to share her experiences, joys and setbacks with others, always focusing on what can be learned and applied in the future. Faculty Profile:  https://scholars.uab.edu/display/henrique

Kids love cheese! (So do adults: Americans consume an average of 40 pounds of cheese per person per year.) In this episode we learn how cheese is made and answer all of your cheesy questions: Why are there different types of cheese? Why do cheeses have different flavors? How do you make Colby Jack cheese? How does cheese get its color? And why do we say cheese when we take a picture? We visit the Cabot Cheese factory and talk with Maegen Olsen and Panos Lekkas. Download our learning guides: PDF | Google Slide Cheese starts with milk. Cheese is often made with milk from cows or goats, but it can also be made with milk from sheep, buffalo, camels or other mammals. (There's even a moose-cheese company in Russia!) If the cheese is made in bulk to sell to lots of people, companies will usually run tests on the milk before they turn it into cheese. They want to make sure it doesn't have bad bacteria or antibiotics in it. The milk is then pasteurized, which means it's heated quickly and cooled quickly to kill any lurking bad bacteria. Next cheesemakers will add a starter culture. Starter culture is GOOD bacteria, which will eat the milk sugar (lactose), create lactic acid and drive down the pH of the milk. That helps create curds. The next step is coagulation! (Coagulation is the process of turning a liquid into a semi-solid or solid.) To coagulate the milk, an enzyme called rennet is added. Now it's time to separate the curds from the whey. Cheesemakers will use knives to cut the coagulated milk into chunks known as curds, leaving some liquid behind. That liquid is known as whey. When milk is made into cheddar it gives a 10% yield, meaning 10% of the milk will become cheese and 90% will be left over as whey. Some cheesemakers, like Cabot, use the whey to make protein powders. In other factories it might go to waste. Next, it's time to add salt. Salt serves as a preservative and gives the cheese flavor. If it's a flavored cheese, things like garlic or peppers will be added at this point. The cheese is then pressed into blocks. At factories like Cabot, they pull the curds into tall towers and then add more and more, creating pressure that forms those curds into solid blocks. Smaller cheesemakers use a cheese press.  In the final step, the cheese is aged. It will sit in a cold storage or cheese cave and just…get older. Cheddar can be aged for years, giving it a stronger flavor. Aging also changes the texture of a cheese like cheddar. It can get more crumbly the older it gets. Once it's ready, it will be cut, packaged and shipped to stores.

“Consider your patient's diagnosis. What kind of cancer do they have? And ask yourself, ‘Could this patient be in disseminated intravascular coagulation (DIC)? Is there something more that we should be doing or looking at?'” Leslie Smith, RN, APRN-CNS, DNP, BMTCN®, AOCNS®, oncology clinical specialist at the National Institutes of Health in Bethesda, MD, told Jaime Weimer, MSN, RN, AGCNS-BC, AOCNS®, oncology clinical specialist at ONS. Smith discussed the nursing considerations for the management of DIC. This episode is part of a series about oncologic emergencies; the others are linked in the episode notes. You can earn free NCPD contact hours after listening to this episode by completing the evaluation linked below. Music Credit: “Fireflies and Stardust” by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at myoutcomes.ons.org by October 7, 2024. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of NCPD by the American Nurses Credentialing Center's Commission on Accreditation. Episode Notes Complete this evaluation for free NCPD. Previous Oncology Nursing Podcast episodes on oncologic emergencies ONS book: Understanding and Managing Oncologic Emergencies: A Resource for Nurses (third edition) ONS courses: Oncologic Emergencies Treatment and Symptom Management—Oncology RN Essentials in Oncologic Emergencies for the Advanced Practice Provider ONS Huddle Cards™ DIC Huddle Card ONS Prevention of Bleeding Symptom Intervention and Guideline UpToDate Information from Cleveland Clinic Information from the National Heart, Lung, and Blood Institute To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From Today's Episode “If the D-dimer is high, that is indicative of a clotting issue occurring. So, the next step for the nurse would be to look for the lab or ask for an order—you can order a DIC panel in some institutions—but look at coagulation labs. And really care and support these patients. DIC is not a disease in itself; it is a symptom of a disease, it is a syndrome. And it's indicative of another problem occurring.” Timestamp (TS) 07:09 “In the chronic form, patients who live in a chronic inflammatory state—maybe from arthritis or whatever the process is—their coagulopathy will not be as severe as an acute form. They may have an elevated prothrombin time (PT) or partial thromboplastin time (PTT). Their platelets may be a little bit low and their fibrinogen may be just a little bit low, but it's not life-threatening. And in an acute stage of DIC, it is life-threatening.” TS 08:43 “If we are taking care of patients who have received CAR T cells, for example, nurses know to monitor for cytokine release syndrome, we're watching for fever, we're watching the C-reactive protein levels or the ferritin levels, and we're treating appropriately via tocilizumabs . . . preventing DIC that way. Patients who are at risk for developing sepsis. . . . watching for signs of impeding infection . . . . Those types of things can prevent DIC from occurring.”  TS 12:26 “I think it can be a little bit confusing for the nurse because they're vague symptoms. So, if you have a patient that is maybe thrombocytopenic, you could attribute, ‘Well, they have all this petechiae from their thrombocytopenia.' It's difficult. That's why you need to really draw a lab. . . . It is not just one lab or one sign or symptom that will diagnosis DIC. There's no one thing that tells you that the patient has DIC. You need to look at all the lab work to make that determination.” TS 14:15 “Nurses are going to support the patient with transfusions. . . . And this will help in an attempt to normalize the lab or at least get the factors and the platelets back up. And then treating the disease. . . . And then in addition, if the patient is infected or septic, administering the antibiotics.” TS 16:26 “DIC is often thought—especially by patients or family—that once you start that chemotherapy or the antibiotics, that the DIC will go away. That is not true. It can take days to weeks for the DIC to resolve itself. It's not something that is going to happen overnight. The patient will need to continue to be supported.” TS 18:13 “Consider what is the diagnosis of your patient. If they have cancer, what kind of cancer do they have? And ask the question to yourself, ‘Could this patient be in DIC? Is there something more that we should be doing or looking at?'” TS 19:22

Join us after hours at Dr. Bryan A. Cotton's pop-up bourbon bar at the AAST 2022 Meeting in Chicago. In this FANTASTIC & FUN episode, we talk amongst friends about cutting edge research at this year's meeting. To no one's surprise, coagulopathy, damage control resuscitation, whole blood, and factor replacement therapy just happen to be but a few of the topics discussed on Rounds.Time Stamps:00:12 AAST 2022 - Intro00:42 Sex diamoprhisms in coagulation01:52 Hemostatic profiles of female donors02:48 Pediatric whole blood (WB) is safe03:10 WB for TBI03:31 Leukoreduction is unnecessary05:30 TXA, TEG  and trauma06:44 STAAMP trial07:21 TXA: go early, big or go home07:52 Calcium...early!09:33 Canadian perspective on TXA and TEG – Neil Perry from London, ON11:25 Nori Bradley from Edmonton, AB13:53 Jordan Weinberg, not Canadian – Phoenix, AZ16:12 Issues with WB – COMBAT vs PAMPer17:31 Cold stored platelets18:22 Rapid transfusers and whole blood: Only the strong survive!!19:42 How are we doing with our resuscitation? 1:1:1 is just the beginning, not the end!21:44 Timing is everything!23:38 Plasma first resuscitation: “…God damn good!” -BAC24:37 Dr. Joshua B. Brown - Pittsburgh, PA25:31 More Canadian perspectives with Perry and Bradley29:48 Less is best!31:27 Prothrombin complex concentrate: Yay or nay?32:18 More on the endotheliopathy of trauma33:38 Just messing around and having a blast34:22 What was the best bourbon tonight?References:CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14. PMID: 20554319.Gruen DS, Guyette FX, Brown JB, Okonkwo DO, Puccio AM, Campwala IK, Tessmer MT, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Neal MD, Zuckerbraun BS, Yazer MH, Billiar TR, Sperry JL. Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial. JAMA Netw Open. 2020 Oct 1;3(10):e2016869. doi: 10.1001/jamanetworkopen.2020.16869. PMID: 33057642; PMCID: PMC7563075.Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ, Nirula R, Vercruysse GA, O'Keeffe T, Joseph B, Alarcon LH, Callaway CW, Zuckerbraun BS, Neal MD, Forsythe RM, Rosengart MR, Billiar TR, Yealy DM, Peitzman AB, Sperry JL; STAAMP Study Group. Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial. JAMA Surg. 2020 Oct 5;156(1):11–20. doi: 10.1001/jamasurg.2020.4350. Epub ahead of print. Erratum in: JAMA Surg. 2021 Jan 1;156(1):105. PMID: 33016996; PMCID: PMC7536625.Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, Chin T, Burlew CC, Pieracci F, West FB, Fleming CD, Ghasabyan A, Chandler J, Silliman CC, Banerjee A, Sauaia A. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet. 2018 Jul 28;392(10144):283-291. doi: 10.1016/S0140-6736(18)31553-8. Epub 2018 Jul 20. PMID: 30032977; PMCID: PMC6284829.Pusateri AE, Moore EE, Moore HB, Le TD, Guyette FX, Chapman MP, Sauaia A, Ghasabyan A, Chandler J, McVaney K, Brown JB, Daley BJ, MSupport the show

REFERENCES: Farkas, Josh. (Feb 14, 2021). Acute Liver Failure. Internet Book of Critical Care. Available: https://emcrit.org/ibcc/alf/ Forkin, Katherine T. MD; Colquhoun, Douglas A. MBChB, MSc, MPH†; Nemergut, Edward C. MD,‡; Huffmyer, Julie L. MD*. The Coagulation Profile of End-Stage Liver Disease and Considerations for Intraoperative Management. Anesthesia & Analgesia: January 2018 - Volume 126 - Issue 1 - p 46-61 doi: 10.1213/ANE.0000000000002394 Mayo Clinic. Liver Function Tests. Available from: https://www.mayoclinic.org/tests-procedures/liver-function-tests/about/pac-20394595 Montreif, Tom. (Nov 25, 2018). Acute Liver Failure: Evidence-Based Evaluation and Management. EM Docs blog. Available: http://www.emdocs.net/acute-liver-failure-evidence-based-evaluation-and-management/ Northup PG, Caldwell SH. Coagulation in liver disease: a guide for the clinician. Clin Gastroenterol Hepatol. 2013 Sep;11(9):1064-74. doi: 10.1016/j.cgh.2013.02.026. Epub 2013 Mar 16. PMID: 23506859.