'Bone Up'

The lads talked to Prof Ken Poole about vertebral fractures. Ken explains that vertebral fractures should be never events because of effective treatments that patients can take. We also discuss Martha's law a patient safety initiative in the NHS that allows patients and their families to request a rapid review if they are concerned about their condition.https://www.england.nhs.uk/patient-safety/marthas-rule/ken Poole is Professor of Metabolic Bone Disease University of Cambridge. Ken applies novel imaging techniques to investigate bone diseases. He also runs NHS clinical services for metabolic bone diseases and specialised rheumatology needs. One key project is the PHOENIX study which aims to improve the diagnosis of vertebral fractures using routine CT scanning.

The lads talked to Dr Elena Tsourdi about personalised care for osteoporosis patients. Elena is working as the Senior Consultant at the Department for Metabolic Bone Diseases, with a focus on secondary osteoporosis and rare bone diseases. We had a fascinating chat about how doctors and patients can build trust and prescribe medicines to get the best outcomes for individual patients.

The lads talked to Professor Roland Baron from Harvard University. Roland has played a key role in characterising bone signalling pathways that govern bone formation and contributed to developing new treatments that increase cell signalling to improve bone mass.Roland is a co-founder and chair of the International Federation of Musculoskeletal Research Societies supporting our community and helping young scientists from the entire world to develop and support people living with osteoporosis.

The lads talked to each other about the exciting news that the National Institute for Health and Care Excellence (Nice) announced it had approved a new drug, Abaloparatide, for use by the health service. It will be available for use on the NHS in England within three months.

The lads talk to Dr Friederike Schulte about exciting research which shows that mechanical loading potentiates the effect of anabolic treatments for osteoporosis, leading to bigger gains in bone mass and strength. Friederike also spoke to us about her role in public outreach as a Co-Founder at the Swiss Fall Prevention Center. The startup works in the community to share knowledge about fall prevention with people at risk of a fracture, including expert lectures in senior and residential homes.

The lads jetted off to sunny Marseille in the South of France to get you updates on the latest bone research. We talked to Federico Moscogiuri, Ralph Muller and Aline Bozec from the IFMRS about supporting global musculoskeletal research. We also chatted with Annegreet Vlug and Petar Milovanovic from the ECTS academy about their research and supporting young scientists.The IFMRS Online Learning Environment (HubLE) provides high-quality, accessible knowledge about MSK research, with an emphasis on innovation, enabling early investigators to learn, share and network with each other and with professionals from across the world.

The lads jetted off to sunny Marseille in the South of France to get you updates on the latest bone research. We talked to Thomas Funck-Brentano about highlights from last year and spoke to some of the young prize winners. We also chatted with Jeroen Geurts and Alex Ireland from the ECTS academy about their research and supporting young scientists.(https://ects-academy.org/)

The lads talked to Dr. Madhavi Vindlacheruvu about frailty and osteoporosis. We discussed what frailty is and how it can be diagnosed, as well as the patient-centred care developed and practiced by the teams at Addenbrookes Hospital in Cambridge. Pre- and post-fracture care is more complex than you would think in geriatric patients. Dr Madhavi is a consultant orthogeriatrican at Addenbrookes Hospital in Cambridge and Clinical lead for National Hip Fracture Database, and the Fracture Liaison Services at the trust

The lads talk to Dr Jennie Walsh about bone health in teenager years and young adults. We discussed how doctors asses and treat low bone density in young people. We also talked about the effect of eating disorders on bone health. Dr Walsh is a Senior Clinical Lecturer in the Metabolic Bone Centre at the University of Sheffield.

The lads talk to each other and David chats to Richie about his research into bone quality at Imperial College London. Hear about how air pollution can cause osteoporosis, why ballet dancers get stress fractures and everything you wanted to know about nanoscale bone health in this month's episode of BoneUp the podcast.

The lads talked to Dr Jarod Wong about Duchenne Muscular Dystrophy and new research for developing international management guidelines. Dr Wong is using a mixed methods approach to include patients and their families in the design of new management strategies.

The lads went to Liverpool for the European Calcified Tissue Society annual meeting in 2023. A huge collection of bone scientists creating basic and clinical research. Join us for a fascinating insight into what's hot in bone research now!Every guest received an iconic and rare BoneUp Live mug!

The lads went to Liverpool for the European Calcified Tissue Society annual meeting in 2023. A huge collection of bone scientists creating basic and clinical research. Join us for a fascinating insight into what's hot in bone research now!Every guest received an iconic and rare BoneUp Live mug!

Do you want to join the fight for more equitable health and healthcare? The lads talked to Prof Celia Gregson about her life's mission to make healthcare not just fairer but better. It's a truly fascinating and inspiring insight into how one of our generational leaders is reaching out around the world to make everyone healthier. Sit back and enjoy this episode it's a cracker.Celia Gregson is a Professor of Clinical Epidemiology at Bristol Medical School, Consultant Orthogeriatrician, and Chair of the NOGG - National Osteoporosis Guideline Group.

Want to know how to eat to reduce your risk of a hip-fractures? It's a question our listeners are always asking so the lads reached out to Australia to talk to Dr Sandra Luliano who led an investigation reporting that the risk of falls and of bone and hip fractures decreased in older adults if they received additional daily servings of dairy. The results were startling: 33% fewer bone fractures, 46% fewer hip fractures and 11% fewer falls.Dr Sandra Luliano is a senior researcher at the University of Melbourne based at Austin Health.

Have you ever wondered where osteoporosis medicines come from? The lads went on a journey to find out by talking to Dr Cesar Libanati and Dr Alistair Henry about discovering new medicines and getting them to you the listener. The interview is a fascinating insight into how to change the world and make it a better place for us all to live.Cesar Libanati is the head of external affairs and medical strategy for bone at UCB. Alistair Henry is the Head of discovery science and UK Site head at UCB.

David and Richie visited the BRS Meeting 2022 in Manchester to bring you up to date with the most recent discoveries in bone science. We interviewed a wide variety of clinical and basic scientists from undergraduates taking their first steps in science all the way up to global professors setting treatment guidelines.And to cap it all we won the Neil Mackenzie Public Engagement Award 2022!!

Welcome to the first bonus episode of Bone UP. The first new treatment fir osteoporosis in a decade has been approved in the UK, and many countries around the world.Romosozumab is a new drug treatment for some people living with osteoporosis. It may be suitable if you've already broken a bone due to osteoporosis and are at high risk of breaking another.Richie and David discuss the approval system in the UK, treatment guidelines and mechanism of action. Enjoy!

The lads talk to Kirstie Donaghey and Prof Stuart Ralston about pregnancy-associated osteoporosis.Kirstie suffered multiple osteoporotic fractures shortly after giving birth to her son Freddy and explains the patient journey and perspectives from fracture to treatment. Stuart is a Rheumatologist from the University of Edinburgh with an interest in bone disease. He talks to us about his new research project to investigate osteoporosis in pregnancy.If you would like to take part in Prof Ralston's survey, follow one of these links:PAO Survey (affected patients): https://is.gd/paosurvey2021PAO Survey (unaffected): https://is.gd/paocontrols2021.

The lads talk to Craig Jones about the Royal Osteoporosis Society, a UK based charity that supports bone health around the globeCraig is the Chief Executive Officer of the ROS and has led the development of a new strategy for tackling osteoporosis called ‘Breaking the Silence'. We had a wide-ranging chat about the new strategy and the role of medical charities: including everything from patient support and advocacy in the healthcare and government settings to finding research.https://theros.org.uk/

The lads talk to Prof Gustavo Duque about the crosstalk between bone and muscle in ageing.Gustavo is a geriatrician, clinical researcher and a world leader in ageing and musculoskeletal research, with a special interest in the treatment of frailty osteoporosis, sarcopenia and in older persons.We had an exciting chat about the crosstalk between bone and muscle and how communication between the two organs is important for ageing and the risk of falls and fractures.Prof Duque Gustavo is Chair of Medicine at the University of Melbourne.

The lads talk to Prof Kate Ward about the challenges caused by osteoporosis in Sub-Saharan Africa.Kate is a key member of the FRACURES-E3 research study team investigating epidemiology, Economic Impact and Ethnography. We have a fascinating chat about the risk factors, management, and treatment of osteoporosis in Africa. Join us to hear all about this generation-defining bone research.https://www.bristol.ac.uk/translational-health-sciences/research/musculoskeletal/rheumatology/research/global-musculoskeletal-health/fractures/

Dr Kassim Javiad joins us from Oxford University to discuss how Fracture Liason Services can identify people at high risk of an imminent fracture. Why fractures in people aged over 50 are so dangerous and the new range of anabolic bone-building treatments available to patients. We also discuss the need for osteoporosis to get its own speciality doctors - because it's complicated (apparently).

Join us chatting to Dr Alex Mavroeidi from the University of Strathclyde Glasgow - an expert in exercise, sedentary behaviour and bone health. Alex gives a fascinating insight into the role that exercise can play in preventing fractures. Spoiler later check out the Royal Osteoporosis Society pages at https://tinyurl.com/nmcj2h3x.Enjoy!

We are excited to have a communication expert & rising star of the osteoporosis world Dr Zoe Paskins in this episode.We discuss all you ever wanted to know about discussing bone health, fracture risk and osteoporosis between patient and doctor.

This month Bone UP talks to Prof Eugene McCloskey who is one of the creators of the online Fracture Risk Assessment Tool. Clinicians and patients use the tool every day to assess the risk of a serious fracture and consider treatment options.

Dr Richie Abel and Prof David Armstrong Introduce themselves before kicking off the first episode of 'bone Up'. the podcast all about bone health and osteoporosis.

Episode 1 -Dr David Armstrong (MD) and Dr Richard Abel (PhD) discuss osteoporosis, fracture risk prediction, management and treatment decisions, before considering the future of care.