Podcasts about clinical endocrinology

The use of anti-diabetic medications such as pioglitazone or GLP-1 receptor agonists in the management of metabolic dysfunction-associated steatotic liver disease (MASLD) is discussed in this podcast. Dr Oliver Tavabie, Deputy Editor at FG and Hepatology Consultant at the Leeds Liver Unit, interviews Drs Scott Isaacs and Paul Brennan. Dr Scott Isaacs is the President of the American Association of Clinical Endocrinology and an Adjunct Associate Professor at Emory University School of Medicine, US. Dr Paul Brennan is a Senior Registrar and Honorary Research Fellow in Hepatology based at Ninewells Hospital, UK. They are authors of the paper "Role of anti-diabetic medications in the management of MASLD”, published online in Frontline Gastroenterology in February 2025. We hope you enjoy the #FGPodcast. Please follow @‌FrontGastro_BMJ. Listen to our regular podcasts and subscribe in Apple Podcasts and Spotify. If you enjoy our podcast, please rate us on your chosen platform, and leave us a review on the Frontline Gastroenterology Podcast page on Apple Podcasts: https://podcasts.apple.com/gb/podcast/fg-podcast/id942944229

A captivating conversation between Sonya and Jo explores the rapidly evolving landscape of menopause healthcare, research, and politics in Australia. In this episode we begin by unpacking the viral podcast between Dr. Rachel Rubin and Dr. Peter Attia – a two-and-a-half hour deep dive into menopause, vaginal health and GSM that's being celebrated as "the best podcast that has been recorded to date on this topic." What makes it exceptional isn't just the content but the peer-to-peer dynamic between two medical professionals sharing both evidence-based information and clinical experience.The conversation takes a powerful turn when journalist Jamila Rizvi's health journey is discussed. At just 31, a missed period led to the discovery of a rare brain tumour affecting her hormone production – a sobering reminder that health changes should never be dismissed without proper investigation. This naturally leads us to a discussion of exciting new research published in Clinical Endocrinology that examines the relationship between sex hormones and dementia risk.Politics takes centre stage as we celebrate Australia's increasingly female Parliament, with two major parties now led by women and gender equality achieved in the Labor cabinet. The shift in ministerial portfolios sees Rebecca White stepping into the Assistant Minister for Health role. We wrap up with news of an Australian company developing the first new estrogen patch in 22 years, potentially addressing supply issues and skin irritation problems plaguing current options.Links:ABC Conversations with Jamila RizviDr Rachel Rubin and Dr Peter Attia Podcast - Apple PodcastsDr Rachel Rubin and Dr Peter Attia Podcast - YouTubeSex Hormones and Risk of Incident Dementia in Men and Postmenopausal Women - Clinical Endocrinology ArticleThank you for listening to my show! Join the conversation on Instagram

Told it's impossible? Let's change that.In this episode, I break down what your AMH (Anti-Müllerian Hormone) levels really mean for your fertility — and why a low AMH is not the final word on your chances of getting pregnant.➡️ What you'll learn in this episode:✅ What AMH actually measures (and what it doesn't)✅ The surprising role of AMH as a “dam” in your ovarian function✅ Why are many women being misled by this one number✅ The difference between egg quantity vs. quality✅ Natural, research-backed strategies to support your fertility — even with low AMH

Cortisol, das Stresshormon, das in vielen Gesundheitsratgebern als der Bösewicht gilt. Doch ist Cortisol wirklich immer negativ? In dieser Folge räumen wir mit Mythen auf: Denn Cortisol ist nicht nur ein Zeichen von Überforderung, sondern kann - richtig dosiert - auch ein echter Performance-Booster sein. Studien zeigen: Kurzfristig erhöhte Cortisolwerte steigern Konzentration, Wachsamkeit und Energie z.B. bei wichtigen Präsentationen, sportlicher Belastung oder bei akuten Herausforderungen. Eine Untersuchung der Harvard Medical School belegt, dass kurzfristiger Stress sogar die Immunantwort verbessern kann, wenn er richtig abgepuffert wird. Praxisbeispiel: Du wachst morgens auf und dein Körper schüttet Cortisol aus, um dich wach und leistungsfähig zu machen. Ganz normal und sogar gewollt. Problematisch wird es erst, wenn der Cortisolspiegel chronisch erhöht bleibt - durch ständige Reizüberflutung, Schlafmangel, schlechte Ernährung oder fehlende Bewegung. Die Folge? Dauerstress bremst nicht nur deine Regeneration aus, sondern kann auch dein Testosteron-Level dramatisch senken. Besonders bei Männern führt das zu Energieverlust, Antriebslosigkeit, schwindender Muskelmasse und Libidoproblemen. Laut einer Studie des Journal of Clinical Endocrinology besteht ein direkter Zusammenhang zwischen chronisch erhöhtem Cortisol und einem drastischen Rückgang des Testosteronspiegels - mit massiven Folgen für Leistung und Lebensqualität. Und genau hier kommt mein ganzheitliches Performance Coaching ins Spiel. Denn viele Männer (und Frauen) haben bereits eine wahre Odyssee hinter sich: - unzählige Arztbesuche - Medikamente, die nur Symptome bekämpfen - Fehldiagnosen oder der Satz „Alles in Ordnung bei Ihnen“ obwohl du dich alles andere als in Ordnung fühlst Ich begleite dich mit fundiertem Wissen, individuell auf deinen Alltag abgestimmt - von körperlichem Training über Ernährung bis hin zu mentaler Stärke und Stressmanagement. Damit du deine hormonelle Balance zurückgewinnst und wieder voll in deine Kraft kommst. Hör rein und finde heraus, warum Cortisol kein Gegner sein muss, sondern dein Körper einfach nur wieder die richtige Steuerung braucht. Wenn du bereit bist, deinen Weg raus aus der Erschöpfung zu gehen, dann bewirb dich jetzt für mein Performance Coaching. Gemeinsam packen wir es an - ganzheitlich, effektiv und nachhaltig. https://andreas-trienbacher.com/coaching/ ___________________________

In this episode of Diabetes Dialogue, hosts Diana Isaacs, PharmD, an endocrine clinical pharmacist, director of Education and Training in Diabetes Technology, and codirector of Endocrine Disorders in Pregnancy at the Cleveland Clinic, and Natalie Bellini, DNP, program director of Diabetes Technology at University Hospitals Diabetes and Metabolic Care Center, are joined by Rifka Schulman-Rosenbaum, MD, director of inpatient diabetes at Long Island Jewish Medical Center and co-author of Establishing Screening Programs for Pre-symptomatic Type 1 Diabetes: Practical Guidance for Diabetes Care Providers, a new paper in the Journal of Clinical Endocrinology and Metabolism. With Bellini as a co-author of the piece, experts explored the increasing clinical and operational momentum behind screening for pre-symptomatic type 1 diabetes (T1D) and what it takes to implement effective programs in real-world settings. The conversation centers on the rationale and logistics behind identifying individuals in stages 1 and 2 of T1D—autoimmune stages characterized by multiple islet autoantibodies before clinical onset. With the availability of teplizumab (Tzield), a disease-modifying therapy shown to delay progression to stage 3 of T1D, the importance of early detection and standardized screening protocols has become more urgent. Schulman-Rosenbaum outlined how her work on the JDRF Breakthrough T1D initiative led to the development of actionable guidance aimed at frontline diabetes care providers. She highlights barriers to implementation—such as limited provider awareness of T1D staging and screening protocols—and details her institution's ongoing efforts to educate primary care clinicians and endocrinologists, including distributing screening handouts and creating streamlined workflows using dot phrases and dedicated follow-up slots. The discussion emphasizes targeted screening for high-risk groups, such as first- and second-degree relatives of individuals with T1D and patients with autoimmune diseases like Hashimoto's or celiac. Schulman-Rosenbaum emphasized the opportunity for endocrinologists to screen these patients directly during routine care and the utility of a centralized handout to guide test ordering and family engagement. Drawing from their paper, experts outlined practical steps for launching autoantibody screening programs: nominating a program champion, forming an implementation team, and embedding screening into existing clinical systems. Experts stressed the importance of using appropriate ICD-10 codes for insurance coverage and referenced a diagnostic coding table in their publication. Schulman-Rosenbaum also addressed the widespread issue of misdiagnosis, particularly in adults mistakenly classified as having type 2 diabetes, and outlines best practices for using antibody and C-peptide testing to refine diagnosis. She detailed her hospital's approach to inpatient screening, noting an increased use of autoantibody testing and follow-up coordination for patients with suspected T1D or latent autoimmune diabetes in adults (LADA). Finally, the episode highlighted how to monitor individuals who test positive for a single antibody or exhibit mild dysglycemia, noting that many fall outside established risk categories. Experts called for more research in this area and advocate for individualized monitoring strategies based on clinical risk, family history, and emerging glucose patterns—often using continuous glucose monitoring (CGM) data. Relevant disclosures for Isaacs include Eli Lilly and Company, Novo Nordisk, Sanofi, Abbott Diabetes Care, Dexcom, Medtronic, and others. Relevant disclosures for Bellini include Abbott Diabetes Care, MannKind, Provention Bio, and others. Key Episode Timestamps 00:00:00 Introduction 00:02:18 Inspiration Behind the Paper 00:04:12 Challenges in Implementing T1D Screening 00:07:32 Educating Providers and Overcoming Barriers 00:09:32 Addressing Misdiagnosis of Diabetes 00:12:01 Inpatient Screening Practices 00:16:13 Support and Resources for Patients with Positive Antibodies 00:20:01 Conclusion and Final Thoughts

On this episode we review the 2025 Clinical Practice Guideline for the Pharmacologic Management of Adults with Dyslipidemia published by the American Association of Clinical Endocrinology. We compare and contrast the common medications used in the management of dyslipidemia and examine how these can be utilized based on the 13 updated recommendations found in the 2025 guidelines.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. If you purchase an annual membership, you'll also get a free digital copy of High-Powered Medicine 3rd edition by Dr. Alex Poppen, PharmD. HPM is a book/website database of summaries for over 150 landmark clinical trials.You can visit our Patreon page at the website below:  www.patreon.com/corconsultrx We want to give a big thanks to Dr. Alex Poppen, PharmD and High-Powered Medicine for sponsoring the podcast..  You can get a copy of HPM at the links below:  Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to say thank you to our sponsor, Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx We also want to thank our sponsor Freed AI. Freed is an AI scribe that listens, prepares your SOAP notes, and writes patient instructions. Charting is done before your patient walks out of the room. You can try 10 notes for free and after that it only costs $99/month. Visit the website below for more information: https://www.getfreed.ai/  If you have any questions for Cole or me, reach out to us via e-mail: Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com

Von Hormonproduktion über Verdauung bis hin zur Energieverwertung: Der circadiane Rhythmus beeinflusst fast alle physiologischen Funktionen. Wenn wir im Einklang mit unserer inneren Uhr leben, funktioniert unser Körper effizienter und Verdauungsprobleme können besser gelöst werden. ShownotesIn dieser Folge dreht sich alles um den Zusammenhang von Stoffwechsel und zirkadianem Rhythmus. Ich teile meine wichtigsten Erkenntnisse, die dir helfen können, Verdauungsprobleme gezielt anzugehen, deine Ernährung in Einklang mit natürlichen Rhythmen zu bringen und kleine Veränderungen stressfrei in deinen Alltag zu integrieren - auch, wenn du zum Beispiel im Schichtdienst arbeitest. Dafür werfen wir einen Blick auf moderne wissenschaftliche Erkenntnisse und verbinden diese mit dem individuellen Ansatz des Ayurveda, um mit statt gegen unseren Körper zu arbeiten.In dieser Folge erfährst duWie der zirkadiane Rhythmus auf biologischer Ebene funktioniertWie dieser Rhythmus sich auf deine (Verdauungs-)hormone und deinen Stoffwechsel auswirktWie der Ayurveda und die aktuelle wissenschaftliche Studienlage die Relevanz des zirkadianen Rhythmus für unsere Essenszeiten bewertenWelche gesundheitlichen Folgen es haben kann, wenn wir gegen unsere innere Uhr lebenWelche Essenszeiten ideal sind und wie du deinen Stoffwechsel mit der idealen Mahlzeitenzusammensetzung unterstützen kannst (das geht auch, wenn du z. B. im Schichtdienst arbeitest)Konntest du etwas für dich mitnehmen? Dann würde ich mich riesig über deinen Like freuen.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-426 Overview: Drinking coffee offers potential health benefits—but does timing affect outcomes? This episode dives into new research on how morning vs. all-day coffee consumption impacts cardiovascular disease and all-cause mortality risk. Gain practical insights to optimize patient recommendations based on the latest evidence. Episode resource links: European Heart Journal (2025) 00, 1–11 https://doi.org/10.1093/eurheartj/ehae871 The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–11 https://doi.org/10.1210/clinem/dgae552 Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-426 Overview: Drinking coffee offers potential health benefits—but does timing affect outcomes? This episode dives into new research on how morning vs. all-day coffee consumption impacts cardiovascular disease and all-cause mortality risk. Gain practical insights to optimize patient recommendations based on the latest evidence. Episode resource links: European Heart Journal (2025) 00, 1–11 https://doi.org/10.1093/eurheartj/ehae871 The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–11 https://doi.org/10.1210/clinem/dgae552 Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Mándanos un mensaje¿Alguna vez has sentido que sigues todas las reglas pero tu cuerpo no responde como esperabas? La respuesta podría estar en tus biomarcadores, esas pequeñas señales químicas que revelan la verdad sobre tu salud mucho antes que cualquier síntoma visible.Organizaciones de saludAmerican Diabetes Association (ADA): https://diabetes.org/American Heart Association (AHA): https://www.heart.org/World Health Organization (WHO): https://www.who.int/National Institutes of Health (NIH): https://www.nih.gov/Centers for Disease Control and Prevention (CDC): https://www.cdc.gov/Endocrine Society: https://www.endocrine.org/American College of Rheumatology: https://www.rheumatology.org/American Association for the Study of Liver Diseases: https://www.aasld.org/Estudios científicos específicosHemoglobina A1C: American Diabetes Association. (2021). Glycemic Targets: Standards of Medical Care in Diabetes. Diabetes Care, 44(Supplement 1): S73-S84.Ferritina y rendimiento: Sim, M., et al. (2019). Iron considerations for the athlete: a narrative review. European Journal of Applied Physiology, 119(7): 1463-1478.Miocinas: Pedersen, B. K. (2019). Physical activity and muscle-brain crosstalk. Nature Reviews Endocrinology, 15(7): 383-392.Perfil lipídico y riesgo cardiovascular: Grundy, S. M., et al. (2019). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Journal of the American College of Cardiology, 73(24): e285-e350.Vitamina D: Holick, M. F., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7): 1911-1930.Enzimas hepáticas: Kwo, P. Y., et al. (2017). ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. The American Journal of Gastroenterology, 112(1): 18-35.Ácido úrico y enfermedad cardiovascular: Borghi, C., et al. (2020). Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk. Cardiology, 145(1): 1-10.Variabilidad de frecuencia cardíaca: Shaffer, F., & Ginsberg, J. P. (2017). An Overview of Heart Rate Variability Metrics and Norms. Frontiers in Public Health, 5: 258.Support the showInstagram: andieillanesPágina web: andieillanes.com.mx

I denne episoden har vi Tommy Lundberg som gjest. Tommy jobber ved det Karolinska Institut som foreleser og forsker. Sammen med hans kolleger forsker han bl.a. på concurent training der han ser på hvordan utholdenhetstrening og styrketrening påvirker hverandre, og på transkjønns behandlingsmetoder og hvilke implikasjoner det kan ha for idrettslig deltakelse. Har 12 mnd testosteron-hemmende behandling en effekt på fysiske parametere som styrke og utholdenhet, slik at transkvinner og kvinner konkurrerer på samme grunnlag? Burde man løpe eller sykle dersom man vil unngå å miste styrke-"gainz"? Dette er et lite knippe av spørsmål som du vil få svar på i denne episoden! God lytting!Kontaktinformasjon:⁠https://ki.se/en/people/tommy-lundberghttps://twitter.com/tlexercise⁠⁠⁠https://www.researchgate.net/profile/Tommy_Lundberg⁠⁠https://www.instagram.com/tlexercise/?hl=nb⁠Referanser:Lundberg, T. R., Fernandez-Gonzalo, R., Gustafsson, T., & Tesch, P. A. (2013). Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training. Journal of applied physiology, 114(1), 81-89.Lundberg, T. R., Fernandez-Gonzalo, R., Gustafsson, T., & Tesch, P. A. (2012). Aerobic exercise alters skeletal muscle molecular responses to resistance exercise. Medicine & Science in Sports & Exercise, 44(9), 1680-1688.Lundberg, T. R., Fernandez-Gonzalo, R., & Tesch, P. A. (2014). Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men. Journal of applied physiology, 116(6), 611-620.Fernandez‐Gonzalo, R., Lundberg, T. R., & Tesch, P. A. (2013). Acute molecular responses in untrained and trained muscle subjected to aerobic and resistance exercise training versus resistance training alone. Acta Physiologica, 209(4), 283-294.Wiik, A., Andersson, D. P., Brismar, T. B., Chanpen, S., Dhejne, C., Ekström, T. J., ... & Lindholm, M. E. (2018). Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study. Contemporary Clinical Trials Communications, 10, 148-153.Wiik, A., Lundberg, T. R., Rullman, E., Andersson, D. P., Holmberg, M., Mandić, M., ... & Arver, S. (2020). Muscle Strength, Size, and Composition Following 12 Months of Gender-affirming Treatment in Transgender Individuals. The Journal of Clinical Endocrinology & Metabolism, 105(3), e805-e813.Anna, W., Lundberg, T. R., Eric, R., Andersson, D. P., Mats, H., Mirko, M., ... & Stefan, A. (2020). Muscle strength, size and composition following 12 months of gender-affirming treatment in transgender individuals. The Journal of Clinical Endocrinology & Metabolism.Lundberg, T. (2019). Long-Term Effects of Supplementary Aerobic Training on Muscle Hypertrophy. In Concurrent Aerobic and Strength Training (pp. 167-180). Springer, Cham.Schumann, M., & Rønnestad, B. R. (Eds.). (2018). Concurrent aerobic and strength training: Scientific basics and practical applications. Springer.

Les hommes et les femmes ne sont pas égaux, mais ce n'est pas une question de société mais bel est bien de nature humaine. Comment gérer ces différences pour en faire une force ?

Coffee consumption is increasing in the United States, with 67% of adults drinking coffee, according to the National Coffee Association.Researchers suggest that moderate coffee consumption can offer health benefits, including a reduced risk of type 2 diabetes, coronary heart disease, and stroke.A recent study published in the Journal of Clinical Endocrinology and Metabolism found that the benefits of coffee were highest for those who drank a moderate amount, defined as three cups or 200 to 300 milligrams of caffeine per day.The Mayo Clinic also states that coffee can lower the risk of Alzheimer's, Parkinson's, liver disease, certain cancers, and kidney stones. However, dietitians warn that excessive caffeine intake can increase anxiety and disrupt sleep.It's also important to consider the amount of sugar, cream, and other additives in each cup of coffee.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today, Trista Chan discusses the complex relationship between PCOS and weight gain, addressing common misconceptions and the impact of weight stigma. She explores both extrinsic and intrinsic factors contributing to weight gain in individuals with PCOS, emphasizing the importance of understanding these factors rather than placing blame on personal habits. This episode also highlights the detrimental effects of weight stigma on mental and physical health, and offers practical strategies for individuals seeking to navigate their relationship with weight and health. Trista advocates for a body neutrality approach, encouraging listeners to focus on self-care and well-being rather than solely on weight loss. In this episode, you'll learn: Weight stigma can exacerbate health issues in those with PCOS Intrinsic factors like hormones play a significant role in weight gain Weight loss is often misprescribed as a treatment for unrelated health issues Body neutrality allows for a healthier relationship with self-image Diet and lifestyle changes can improve PCOS symptoms without focusing solely on weight Episode links: PCOS Recovery Program - starts February 12th! References Álvarez-Blasco F, Luque-Ramírez M, Escobar-Morreale HF. Diet composition and physical activity in overweight and obese premenopausal women with or without polycystic ovary syndrome. Gynecol Endocrinol 2011;27:978-81. Douglas CC, Norris LE, Oster RA, Darnell BE, Azziz R, Gower BA. Difference in dietary intake between women with polycystic ovary syndrome and healthy controls. Fertil Steril 2006;86:411-7 Georgopoulos NA, Saltamavros AD, Vervita V, et al. Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance. Fertil Steril 2009;92:250-5. 220.  Helena Teede et al. International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023. Monash University. https://doi.org/10.26180/24003834.v1Himmelstein MS, Puhl RM, Quinn DM. Intersectionality: An Understudied Framework for Addressing Weight Stigma. Am J Prev Med 2017;53:421-31. Hosseini MS, Dizavi A, Rostami H, Parastouei K, Esfandiari S. Healthy eating index in women with polycystic ovary syndrome: a case-control study. Int J Reprod Biomed 2017;15:575-82 Huijgen NA, Laven JS, Labee CT, Louwers YV, Willemsen SP, Steegers-Theunissen RP. Are dieting and dietary inadequacy a second hit in the association with polycystic ovary syndrome severityPLoS One 2015;10:e0142772. Moran LJ, Ranasinha S, Zoungas S, McNaughton SA, Brown WJ, Teede HJ. The contribution of diet, physical activity and sedentary behaviour to body mass index in women with and without polycystic ovary syndrome. Human reproduction 2013;28:2276-83. Moran LJ, Brown WJ, McNaughton SA, Joham AE, Teede HJ. Weight management practices associated with PCOS and their relationships with diet and physical activity. Human reproduction 2017;32:669-78 Moran LJ, Noakes M, Clifton PM, et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. The Journal of Clinical Endocrinology & Metabolism 2004;89:3337-44.  Puhl RM, Heuer CA. The stigma of obesity: a review and update. Obesity (Silver Spring) 2009;17:941-64 Robinson S, Chan SP, Spacey S, Anyaoku V, Johnston DG, Franks S. Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clin Endocrinol (Oxf) 1992;36:537-43. 221.

What is the difference between Germ Theory and Terrain Theory? Where did each way of thinking come from, how do they differ in terms of key principles, and how do they impact treatment of disease? Tune in to hear us compare and contrast and give our two cents on what each one has gotten right or wrong.    In this episode, we unpack the historical origins of both Germ Theory and Terrain Theory. We discuss how each one has impacted medicine, from hygiene and sanitation to pharmaceutical intervention and beyond. Plus we discuss key aspects of how you can best support your body's individual terrain and immune system and share our Strep Throat Protocol.    Also in this episode:  Free Detox Class 1/8/25 Sign Up Here Free Keto Masterclass 1/15/25 Sign Up Here Save the Date, next LIVE Keto Reset starts 1/29 Buy 3 Get 1 Free Tea with code FREETEA What is Germ Theory? Historical Origins Shortcomings What is Terrain Theory? Nutrient Deficiency Vitamin D Balanced Blend Bio-C Plus Cellular Antiox Sugar Consumption Naturally Nourished Episode 262 The Keto-Immune Connection Gut Microbiome Beat the Bloat Cleanse Rebuild Spectrum Probiotic GI Immune Builder Stress Stress Manager Bundle Relax and Regulate Sleep Support Detox 10 Day Detox Branch Basics use code ALIMILLERRD on a starter kit Air Quality Air Doctor use code ALIMILLERRD Strep Throat Protocol References Wang, T., et al. (2014). The role of vitamin D in immunity and inflammation. Journal of Nutritional Biochemistry, 25(5), 499–505. Martineau, A. R., et al. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. The Lancet Infectious Diseases, 17(8), 810–818. Johnson, R. J., et al. (2014). Consumption of sugar-sweetened beverages and reduced immune function: An examination of leukocyte function and inflammation. The American Journal of Clinical Nutrition, 100(4), 1141-1146. Cranford, R. R., et al. (2002). The effects of dietary sugar on neutrophil function. The American Journal of Clinical Nutrition, 75(4), 781-785. Adkins, Y., et al. (2006). Acute intake of sugar-sweetened beverages decreases immune function. The Journal of Clinical Endocrinology & Metabolism, 91(2), 615–618. Shin, N. R., et al. (2015). The gut microbiota and its implications for health and disease. Frontiers in Immunology, 6, 121. Belkaid, Y., & Hand, T. (2014). Role of the microbiota in immunity and inflammation. Nature Reviews Immunology, 16(6), 390–400. Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of research. Psychoneuroendocrinology, 30(10), 1023–1039. Black, P. H., & Garbutt, L. D. (2002). Stress, inflammation, and cardiovascular disease. Brain, Behavior, and Immunity, 16(3), 331–338. Bryant, P. A., et al. (2004). Sleep and immune function. Journal of Immunology, 173(4), 2149–2156. Prather, A. A., et al. (2015). Sleep and C-reactive protein: A systematic review and meta-analysis. Sleep, 38(6), 827–835. Source: Saito, H., et al. (2014). Liver detoxification and its importance for health. Hepatology International, 8(1), 15–20. Brook, R. D., et al. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Environmental Health Perspectives, 118(8), 1150–1156. Nieman, D. C. (2013). Exercise immunology: An introduction. Exercise Immunology Review, 19, 8–20. Sponsors for this episode:  According to extensive research by the Environmental Working Group, virtually every home in America has harmful contaminants in its tap water. That's why you've got to check out AquaTru. AquaTru purifiers use a 4-stage reverse osmosis purification process, and their countertop purifiers work with NO installation or plumbing. It removes 15x more contaminants than ordinary pitcher filters and are specifically designed to combat chemicals like PFAS in your water supply. Naturally Nourished Podcast listeners can use code ALIMILLERRD at AquaTru.com to save 20% off. 

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-410 Overview: In this episode, we discuss the latest updates on vitamin D. Learn about its link to common disorders, when to consider supplementation, and what the most recent practice guideline says about vitamin D and disease prevention—empowering you to make informed decisions and improve patient care without unnecessary screenings or treatments. Episode resource links: Marie B Demay, Anastassios G Pittas, Daniel D Bikle, Dima L Diab, Mairead E Kiely, Marise Lazaretti-Castro, Paul Lips, Deborah M Mitchell, M Hassan Murad, Shelley Powers, Sudhaker D Rao, Robert Scragg, John A Tayek, Amy M Valent, Judith M E Walsh, Christopher R McCartney, Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 8, August 2024, Pages 1907–1947, https://doi.org/10.1210/clinem/dgae290 Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver, Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1911–1930, https://doi.org/10.1210/jc.2011-0385 Guest: Jillian Joseph, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-410 Overview: In this episode, we discuss the latest updates on vitamin D. Learn about its link to common disorders, when to consider supplementation, and what the most recent practice guideline says about vitamin D and disease prevention—empowering you to make informed decisions and improve patient care without unnecessary screenings or treatments. Episode resource links: Marie B Demay, Anastassios G Pittas, Daniel D Bikle, Dima L Diab, Mairead E Kiely, Marise Lazaretti-Castro, Paul Lips, Deborah M Mitchell, M Hassan Murad, Shelley Powers, Sudhaker D Rao, Robert Scragg, John A Tayek, Amy M Valent, Judith M E Walsh, Christopher R McCartney, Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 8, August 2024, Pages 1907–1947, https://doi.org/10.1210/clinem/dgae290 Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver, Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1911–1930, https://doi.org/10.1210/jc.2011-0385 Guest: Jillian Joseph, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

In this episode, Trista explores the complexities of managing pregnancy with PCOS, focusing on dietary considerations, the safety of medications and supplements, and the importance of mental health during the postpartum period. She emphasizes the need for careful monitoring of blood sugar levels, the role of insulin and metformin, and the significance of support systems for new parents. You'll learn: Why managing glycemic load is crucial for pregnant individuals with PCOS Safe and effective treatments for gestational diabetes How postpartum mental health is a significant concern for new parents Navigating potential chest feeding challenges for those with PCOS Episode Links: How to Manage Gestational Diabetes with Diet and Lifestyle 1-on-1 Nutrition Coaching References: Choudhury, A. A., & Rajeswari, V. D. (2022). Polycystic ovary syndrome (PCOS) increases the risk of subsequent gestational diabetes mellitus (GDM): A novel therapeutic perspective. Life Sciences (1973), 310, 121069–121069. https://doi.org/10.1016/j.lfs.2022.121069 Diabetes Canada. (2024). Gestational diabetes. https://www.diabetes.ca/about-diabetes/gestational Facchinetti, F., Cavalli, P., Copp, A. J., D'Anna, R., Kandaraki, E., Greene, N. D. E., & Unfer, V. (2020). An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opinion on Drug Metabolism & Toxicology, 16(12), 1187–1198. https://doi.org/10.1080/17425255.2020.1828344 Ibrahim, I., Bashir, M., Singh, P., Al Khodor, S., & Abdullahi, H. (2022). The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control. Frontiers in Nutrition (Lausanne), 9, 867099–867099. https://doi.org/10.3389/fnut.2022.867099 Jorquera, G., Echiburú, B., Crisosto, N., Sotomayor-Zárate, R., Maliqueo, M., & Cruz, G. (2020). Metformin during Pregnancy: Effects on Offspring Development and Metabolic Function. Frontiers in Pharmacology, 11, 653–653. https://doi.org/10.3389/fphar.2020.00653 Koric, A., Singh, B., VanDerslice, J. A., Stanford, J. B., Rogers, C. R., Egan, D. T., Agyemang, D. O., & Schliep, K. (2021). Polycystic ovary syndrome and postpartum depression symptoms: a population-based cohort study. American Journal of Obstetrics and Gynecology, 224(6), 591.e1-591.e12. https://doi.org/10.1016/j.ajog.2020.12.1215 Ryssdal, M., Vanky, E., Stokkeland, L. M. T., Jarmund, A. H., Steinkjer, B., Løvvik, T. S., Madssen, T. S., Iversen, A.-C., & Giskeødegård, G. F. (2023). Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS. The Journal of Clinical Endocrinology and Metabolism, 108(9), e743–e753. https://doi.org/10.1210/clinem/dgad145 Slouha, E., Alvarez, V. C., Gates, K. M., Ankrah, N. M. N., Clunes, L. A., & Kollias, T. F. (2023). Gestational Diabetes Mellitus in the Setting of Polycystic Ovarian Syndrome: A Systematic Review. Curēus (Palo Alto, CA), 15(12), e50725–e50725. https://doi.org/10.7759/cureus.50725 Vanky, E., Isaksen, H., Haase Moen, M., & Carlsen, S. M. (2008). Breastfeeding in polycystic ovary syndrome. Acta Obstetricia et Gynecologica Scandinavica, 87(5), 531–535. https://doi.org/10.1080/00016340802007676

En vieillissant, la qualité et la quantité de sommeil tendent à diminuer, un phénomène bien documenté par la recherche scientifique. Plusieurs facteurs physiologiques et neurologiques contribuent à ces changements. Changements dans les cycles du sommeilLe sommeil se compose de plusieurs cycles, dont le sommeil lent profond, qui est le plus réparateur. Avec l'âge, la proportion de sommeil profond diminue, tandis que les phases de sommeil léger augmentent. Une étude de *Sleep Medicine Reviews* en 2017 a montré que les personnes âgées passent moins de temps en sommeil profond, ce qui rend leur sommeil plus facilement interrompu. Cela signifie qu'ils se réveillent plus fréquemment durant la nuit et ressentent souvent un sommeil moins reposant. Modification de l'horloge biologiqueL'horloge interne, ou rythme circadien, qui régule le cycle veille-sommeil, devient moins stable avec l'âge. Les personnes âgées ressentent souvent une tendance à s'endormir plus tôt le soir et à se réveiller plus tôt le matin, un phénomène appelé « avancement de phase ». Une étude publiée dans *Chronobiology International* en 2018 a montré que ce changement dans l'horloge biologique est dû à une réduction de la sensibilité à la lumière et à des modifications dans la production de mélatonine, une hormone régulatrice du sommeil. Réduction de la production de mélatonineLa mélatonine, souvent appelée « hormone du sommeil », aide à induire le sommeil et à maintenir un rythme de sommeil régulier. En vieillissant, le corps produit moins de mélatonine, ce qui peut rendre l'endormissement plus difficile et le sommeil moins profond. Une recherche dans *Journal of Clinical Endocrinology & Metabolism* a révélé que les niveaux de mélatonine baissent progressivement avec l'âge, ce qui explique en partie pourquoi les personnes âgées peuvent avoir des difficultés à dormir aussi longtemps ou aussi profondément. Facteurs de santé et médicamentsLes troubles de santé chroniques, comme les douleurs articulaires, l'arthrite, ou les problèmes urinaires, peuvent également perturber le sommeil. Par ailleurs, de nombreux médicaments prescrits aux personnes âgées, comme les traitements pour la tension artérielle ou les diurétiques, peuvent avoir des effets secondaires qui nuisent au sommeil. Selon une étude publiée en 2015 dans *Sleep Health*, plus de la moitié des personnes âgées rapportent des interruptions de sommeil dues à des douleurs ou des besoins fréquents d'uriner la nuit. En somme, le vieillissement affecte le sommeil à plusieurs niveaux, de la structure même des cycles de sommeil à la régulation hormonale. Ces changements sont une combinaison de facteurs biologiques, de modifications de l'horloge biologique, et d'effets liés aux conditions de santé, ce qui explique pourquoi le sommeil devient moins profond et plus interrompu avec l'âge. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Episode hosted by Dr. Julie Foucher of the Pursuing Health Podcast, on Sep 17, 2024: #PursuingHealth Tony Nader, MD, PhD is a medical doctor trained at Harvard University and Massachusetts Institute of Technology (Ph.D. in neuroscience) and a globally recognized expert in the science of Consciousness and human development. Dr. Nader, whose training includes internal medicine, psychiatry, and neurology, is a bestselling author (One Unbounded Ocean of Consciousness), with his book Consciousness is All There Is recently released on August 6 (Penguin/Hay House). He is the successor to Maharishi Mahesh Yogi and the head of the Transcendental Meditation organizations globally. Dr Nader conducted research on neurochemistry, neuroendocrinology, and the relationship between diet, age, behavior, mood, seasonal influences, and neurotransmitter and hormonal activity, and on the role of neurotransmitter precursors in medicine. Dr. Nader's interest to explore the full potential of the human physiology, and the human mind led him to also study and conduct research on ancient and modern techniques of self-development. For many years, Dr. Nader worked closely with Maharishi Mahesh Yogi, who first introduced Transcendental Meditation or TM® to the world in 1958, and who emphasized the scientific understanding and validation of Transcendental Meditation. Dr. Nader has discussed his expertise at academic institutions such as Harvard Business School on The Neuroscience of Transcendence, Stanford University, where he gave talks in a series entitled "Hacking Consciousness" as well as the keynote speaker for a number of conferences at the House of Commons, British Parliament. His research has been published in Neurology, Journal of Clinical Endocrinology and Metabolism, Journal of Gerontology, Progress in Brain Research, and many other journals. Dr. Nader has been awarded many time for his outstanding contribution in human development, environment, education, and health. You can connect with Dr. Nader via Instagram @drtonynader https://www.instagram.com/drtonynader If you like this episode, please subscribe to Pursuing Health on iTunes and give it a rating or share your feedback on social media using the hashtag #PursuingHealth. I look forward to bringing you future episodes with inspiring individuals and ideas about health. Disclaimer: This podcast is for general information only, and does not provide medical advice. I recommend that you seek assistance from your personal physician for any health conditions or concerns. iTunes: https://goo.gl/UFjY0q | Stitcher: http://goo.gl/xKMmiR | Spotify: https://spoti.fi/3aiTnBg | Google Play: http://bit.ly/2vrlTSD To order Dr Tony Nader's book Consciousness Is All There Is: https://www.drnaderbooks.com or use your favorite bookseller. Website https://www.drtonynader.com Instagram https://instagram.com/drtonynader Facebook https://facebook.com/DrTonyNader YouTube https://youtube.com/@DrTonyNader X https://x.com/DrTonyNader TikTok https://tiktok.com/@drtonynader Original podcast episode link https://youtu.be/V4QecGh3lNQ?si=wP7VzRkYHSlqz0wm To learn Transcendental Meditation https://www.tm.org To view the Meditate America event https://live.meditateamerica.org Maharishi International University https://www.miu.edu

Today's discussion centers on the pitfalls of exercise and why many individuals struggle to see results despite their hard work. Overtraining syndrome, which can lead to persistent fatigue, irritability, and a lack of motivation, is a significant barrier to achieving fitness goals. The episode explores how excessive exercise can disrupt hormone levels, particularly in women, impacting energy, recovery, and overall well-being. Additionally, the relationship between diet and exercise is examined, emphasizing the importance of balanced nutrition for optimal performance and recovery. Tune in as we delve into practical strategies for finding the right balance between exercise intensity, recovery, and nutrition to enhance your fitness journey.Takeaways: Overtraining can lead to negative side effects, including persistent fatigue and irritability, impacting workout motivation. Women should adjust workout intensity according to their menstrual cycle for optimal performance and recovery. Chronic inflammation caused by excessive exercise without recovery can impair immune function and performance. Nutrition quality, not just calorie count, is essential for effective workout recovery and overall health. Exercise can disrupt hormonal balance, particularly in women, leading to menstrual irregularities and lower energy levels. Proper recovery, including sleep and rest days, is crucial for achieving fitness goals and preventing burnout. Nutrigenomics and how they impact your nutrition and exercise to ensure optimal results.West Wellness and Longevity LinksAre you ready to make change but don't know where to start. Book a free 30 min consultation here.https://www.westwellnessatx.com/get-started Have questions? Feel free to reach out to me at: tarawest@westwellnessatx.com Follow me on instagram @westwellnessatxStudy Links:Nieman, D. C. (1994). Exercise, infection, and immunity. International Journal of Sports Medicine, 15(S3), S131-S141. https://doi.org/10.1055/s-2007-1021128Pedersen, B. K., & Fischer, C. P. (2007). Physiological roles of muscle-derived interleukin-6 in response to exercise.Current Opinion in Clinical Nutrition and Metabolic Care, 10(3), 265–271. https://doi.org/10.1097/MCO.0b013e3282f3f81aMountjoy, M., et al. (2014). The IOC consensus statement: beyond the female athlete triad—Relative Energy Deficiency in Sport (RED-S). British Journal of Sports Medicine, 48(7), 491-497. https://doi.org/10.1136/bjsports-2014-093502Van Cauter, E., et al. (2014). Sleep loss and the pathophysiology of insulin resistance. Journal of Clinical Endocrinology & Metabolism, 99(6), 2198–2207. https://doi.org/10.1210/jc.2014-1737Szabo, A., et al. (2013). Exercise addiction in sportsmen. Psychology of Sport and Exercise, 14(4), 436-445. https://doi.org/10.1016/j.psychsport.2013.03.003Malhotra, A., et al. (2015). It is time to bust the myth of physical inactivity and obesity: you cannot outrun a bad diet.Progress in Cardiovascular Diseases, 57(4), 322–329. https://doi.org/10.1016/j.pcad.2014.11.006Ludwig, D. S., et al. (2002). The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. American Journal of Clinical Nutrition, 76(1), 274S–280S. https://doi.org/10.1093/ajcn/76.1.274Ferguson, L. R., et al. (2017). Nutrigenomics, the microbiome, and gene-environment interactions for health.Nutrients, 9(11), 1133. https://doi.org/10.3390/nu9121133Hansen, M., et al. (2005). The...

Was man teilweise über Vitamin D hört, klingt fast zu schön, um wahr zu sein. Andererseits deuten hunderte verschiedener Forschungsarbeiten darauf hin, dass Vitamin D zur Vorbeugung einer Reihe von Krankheiten beitragen kann – darunter Osteoporose, Depression, Autoimmun- und Herz-Kreislauf-Erkrankungen. Ärzte empfehlen es. Gesundheits- und Fitnesspodcaster sprechen darüber. Vielleicht geht Dir sogar Deine Lieblingstante damit auf die Nerven. Bei all dem Hype ist die Frage berechtigt: "Solltest Du Vitamin D einnehmen?" Hier sind die Antworten – und die neuesten Fakten über ein faszinierendes Vitamin, das ein wahrer Verwandlungskünstler ist. ____________ *WERBUNG: KoRoDrogerie.de: 5% Ermäßigung auf alles mit dem Code „FMM“ beim Checkout. ____________ Ressourcen zur Folge: Literatur: Ratgeber Nahrungsergänzung – Mark Maslow (kostenlos auf MarathonFitness) Blut: Die Geheimnisse unseres flüssigen Organs* – Ulrich Strunz (Heyne) Vitamin D* – Uwe Gröber, Michael F. Holick (Wissenschaftl. Verlagsgesellschaft) Blutuntersuchung (Selbsttest): Vitamin D Test* von Medivere Präparate: D-Form 2.000 K2+* von FormMed D-Form 2.000 K2+ vegan* von FormMed ____________

Host Aaron Lohr talks with Rita Kalyani, MD, professor of medicine at Johns Hopkins University School of Medicine and president-elect of medicine and science at the American Diabetes Association. Earlier this year, Dr. Kalyani and colleagues published a position statement in The Journal of Clinical Endocrinology & Metabolism titled, “Prioritizing Patient Experiences in the Management of Diabetes and Its Complications: An Endocrine Society Position Statement.” Show notes are available at https://www.endocrine.org/podcast/enp93-patience-experience-in-managing-diabetes — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

Join Dr. Lonnie Lowery in this enlightening episode as he reveals groundbreaking research from the International Space Station about a new anabolic agent from green tomatoes, potentially combating age-related muscle loss. Dr. Mike also discusses a recent study linking caffeine consumption to reduced cardiometabolic disease risk. Dive into this exploration of health, strength sports, and nutrition, and stay updated on upcoming changes and expert discussions. Don't miss insights from the Journal of Clinical Endocrinology and Metabolism and future episodes on dietary supplements regulation.00:30 Exploring Muscle Loss in Microgravity02:54 Green Tomato Extract: A Potential Muscle Loss Drug07:08 Caffeine: Is It Healthy?07:23 Iron Radio Updates and Announcements08:35 Dr. Mike T. Nelson's Daily Newsletter09:07 Exclusive Newsletter and Free Information09:45 Exploring Caffeine and Cardiac Health10:18 Study Insights: Coffee and Cardiometabolic Diseases13:10 Caffeine's Potential Benefits and Mechanisms Donate to the show via PayPal HERE.You can also join Dr Mike's Insider Newsletter for more info on how to add muscle, improve your performance and body comp - all without destroying your health, go to www.ironradiodrmike.com Thank you!Phil, Jerrell, Mike T, and Lonnie

In today's episode of Daily Value, we look at the protective effects of coffee, tea, and caffeine consumption on cardiometabolic health. A recent study published in the Journal of Clinical Endocrinology & Metabolism (doi:10.1210/clinem/dgae552) reveals how moderate caffeine intake—equivalent to a specific amount of caffeine—is related to the reduced risk of cardiometabolic multimorbidity, which includes coexistence of conditions like type 2 diabetes, coronary heart disease, and stroke.Episode Talking Points:*The link between caffeine intake and reduced risk of developing cardiometabolic diseases.*Potential mechanisms of protection, including antioxidant and anti-inflammatory effects, improved lipid metabolism, and the role of specific compounds like chlorogenic acid and catechins.*Practical takeaways for incorporating moderate coffee or tea consumption into your daily routine for long-term heart health.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae552/7754545?redirectedFrom=fulltextSupport the show

Ready to ditch calorie counting and unlock the secrets to sustainable weight loss? In this episode of Weight Loss Made Simple, Dr. Stacy Heimburger dives into the multi-pronged approach to holistic weight loss. Discover why focusing on more than just calories is essential for long-term success. We explore the impact of psychological stress, the role of quality sleep, the importance of nutrient-dense foods, effective physical activity, and building a supportive network. Tune in to learn how integrating these lifestyle changes can transform your weight loss journey and overall wellness.References:Psychological Stress and Obesity - A. M. C. Farrow, E. E. White, A. M. Jacobs, Physiology & Behavior, October 2003Sleep and Obesity - M. G. Knutson, L. L. Van Cauter, Current Diabetes Reports, April 2006Nutrient-Dense Foods and Weight Management - K. L. Hlebowicz, E. D. Solomon, M. M. Mitchell, Nutrients, August 2019Physical Activity and Weight Loss - C. S. Albright, R. D. Thompson, G. T. Wright, Journal of Clinical Endocrinology & Metabolism, August 2008Stress Management and Weight Loss - J. K. Smith, R. S. Peterson, L. T. Morgan, Journal of Behavioral Medicine, April 2011Free 2-Pound Plan Call!Want to jump start your weight loss? Schedule a free call where Dr. Stacy Heimburger will work with you to create a personalized plan to lose 2 pounds in one week, factoring in your unique circumstances, challenges, and aspirations. Schedule now! www.sugarfreemd.com/2poundThis episode was produced by The Podcast Teacher.

Tony Nader, MD, PhD is a medical doctor trained at Harvard University and Massachusetts Institute of Technology (Ph.D. in neuroscience) and a globally recognized expert in the science of Consciousness and human development. Dr. Nader, whose training includes internal medicine, psychiatry, and neurology, is a bestselling author (One Unbounded Ocean of Consciousness), with his book Consciousness is All There Is recently released on August 6 (Penguin/Hay House). He is the successor to Maharishi Mahesh Yogi and the head of the Transcendental Meditation organizations globally.   Dr Nader conducted research on neurochemistry, neuroendocrinology, and the relationship between diet, age, behavior, mood, seasonal influences, and neurotransmitter and hormonal activity, and on the role of neurotransmitter precursors in medicine.   Dr. Nader's interest to explore the full potential of the human physiology, and the human mind led him to also study and conduct research on ancient and modern techniques of self-development.   For many years, Dr. Nader worked closely with Maharishi Mahesh Yogi, who first introduced Transcendental Meditation or TM® to the world in 1958, and who emphasized the scientific understanding and validation of Transcendental Meditation.   Dr. Nader has discussed his expertise at academic institutions such as Harvard Business School on The Neuroscience of Transcendence, Stanford University, where he gave talks in a series entitled "Hacking Consciousness" as well as the keynote speaker for a number of conferences at the House of Commons, British Parliament. His research has been published in Neurology, Journal of Clinical Endocrinology and Metabolism, Journal of Gerontology, Progress in Brain Research, and many other journals. Dr. Nader has been awarded  many time for his outstanding contribution in human development, environment, education, and health.   You can connect with Dr. Nader via Instagram @drtonynader Related Episodes: Ep 223 - Tapping to Reduce Stress with Nick Ortner Ep 277 - The Science of Spirituality and Mental Health with Dr. Lisa Miller If you like this episode, please subscribe to Pursuing Health on iTunes and give it a rating or share your feedback on social media using the hashtag #PursuingHealth. I look forward to bringing you future episodes with inspiring individuals and ideas about health. Disclaimer: This podcast is for general information only, and does not provide medical advice.  I recommend that you seek assistance from your personal physician for any health conditions or concerns.

Send us a textHello and welcome to this episode. Today we will be discussing an approach to a low TSH. We will be going over 2 review studies from The Journal of Clinical Endocrinology and Metabolism  and then Cleveland Clinic Journal of Medicine. But first today's question: A 50-year-old postmenopausal woman with no other notable history presenting with palpitations, frequent bowel movements, and tremors. She has no family history of thyroid dysfunction. She has mild tachycardia. Her thyroid gland is 20 g and nontender to palpation. Her TSH is < 0.1. What is the best next step in evaluating this patient?A Thyrotropin receptor antibodiesB Check Total T4C Check Free T4 and T3D Thyroid US And the answer is T4 and Total T3. These questions, while seemingly simple, are actually guaranteed on board exams. Initial thyroid function evaluation should start with TSH. In this case the TSH is low and there is clinical suspicion for hyperthyroidism. If TSH is suppressed, the immediate next step is to check T4 and T3 to confirm and further characterize the thyroid dysfunction (overt vs subclinical). This is worth repeating: investigating the cause of the suppressed TSH by checking thyroid hormones is important in determining how to proceed with evaluation and treatment.   In this question, checking the Free T4 is favored over total T4 because Total T4 levels can be affected by alterations in binding proteins.  Checking T4 only is not sufficient because there are cases of isolated T3 thyrotoxicosis. Ordering receptor antibodies or starting treatment are premature at this point. Thyroid US is not a routine part of the diagnostic algorithm to hyperthyroidism. For this case, an iodine uptake scan could be performed to differentiate thyroiditis from true hyperthyroidism, but this would not be the best next step in this question. An Approach to Low TSHIf the T4 and T3 level are normal, repeat TSH, T4, and T3 in 6-8 weeks before giving a diagnosis. When TSH suppression is transient, most times thyroid dysfunction will be resolved in this time. A suppressed TSH that is not normalized in this period requires more investigation. Low TSH can be differentiated by level of TSH suppression such as mild (TSH 0.1 – 0.4 mIU/L) milli-international units per liter and complete TSH suppression TSH < 0.1 mIU/L. It is unclear the incidence of low TSH within the population but in a representative sample of the US without known thyroid condition that 0.7% of patients had suppressed TSH (< 0.1 mU/L) and 1.8% of patients had a TSH level below the reference range (< 0.4 mU/L) It can be helpful to think of the etiologies of low TSH 1) in their relation to the pituitary/hypothalamus or 2) in terms of accuracy of the assay measurement / drug effect Relationship to Pituitary/Hypothalamus·       Category #1: low TSH due to  an appropriate pituitary response to high thyroid hormone, the pituitary is actively attempting to reduce thyroid hormone production because of advanced or early elevated thyroid hormone levels In this category differentiating the source of the excess thyroid hormone can be helpful·       #1 Excess endogenous thyroid hormone production from multinodular goiter, autonomous thyroid nodule, Graves' disease,·       #2 Exogenous thyroid hormone commonly from excess levothyroxine supplementation (iatrogenic or intentional in context of high risk thyroid cancer) or ingestion of natural thyroid preparations (athletic performance and integrative health) – in   these cases exogenous T4 is suppressing TSSupport the show

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-397 Overview: In this episode, we review the T Trials—a coordinated set of 7 research trials that assessed the efficacy of testosterone gel treatment in 7 functional domains for men aged 65 years or older. Hear best practices for determining testosterone levels and how to balance the benefits and risks of testosterone replacement therapy during patient discussions. Episode resource links: Matsumoto AM. Testosterone Replacement in Men with Age-Related Low Testosterone: What Did We Learn From The Testosterone Trials? Curr Opin Endocr Metab Res. 2019 Jun;6:34-41. doi: 10.1016/j.coemr.2019.04.004. Epub 2019 Apr 25. PMID: 32043015; PMCID: PMC7009797.  The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–10 https://doi.org/10.1210/clinem/dgae085 Guest: Robert A. Baldor MD, FAAFP Music Credit: Richard Onorato Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-397 Overview: In this episode, we review the T Trials—a coordinated set of 7 research trials that assessed the efficacy of testosterone gel treatment in 7 functional domains for men aged 65 years or older. Hear best practices for determining testosterone levels and how to balance the benefits and risks of testosterone replacement therapy during patient discussions. Episode resource links: Matsumoto AM. Testosterone Replacement in Men with Age-Related Low Testosterone: What Did We Learn From The Testosterone Trials? Curr Opin Endocr Metab Res. 2019 Jun;6:34-41. doi: 10.1016/j.coemr.2019.04.004. Epub 2019 Apr 25. PMID: 32043015; PMCID: PMC7009797.  The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–10 https://doi.org/10.1210/clinem/dgae085 Guest: Robert A. Baldor MD, FAAFP Music Credit: Richard Onorato Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Half of the world's population will go through menopause. Yet research shows that a large proportion of women do not feel informed and equipped for menopause. In this episode, we reveal the results of a brand new study that highlight the impact of diet on menopause symptoms. Davina McCall is a British household name and much-loved TV presenter on a mission to change this. Her 2022 book Menopausing provided a roadmap for women to be fearless in tackling this stage of life. She has her own very personal menopause story and today, she shares it with us. Together with ZOE's Chief Scientist Dr. Sarah Berry, we're having an honest and open conversation about perimenopause and menopause.

There has long since been a knowledge gap in medical education regarding care of LGBTQIA+ patients. This has manifested itself in health disparities that detrimentally affect the LGBTQIA+ population. This podcast serves as a way to start bridging the gap on order to mitigate the effects of bias, discrimination, and prejudice that queer patients often face in health care. Research has shown that consistent, early exposure in medical education to patients from the queer community has been beneficial in preparing future practitioners for gender inclusive care. We must also do our parts as pediatricians to make sure our queer youth grow into confident, thriving queer adults.  Join Dr. Farrah-Amoy Fullerton, a recent graduate of the pediatric residency program at MCG, and Professor of Pediatrics, Dr. Lisa Leggio, as they introduce LGBTQIA+ health care disparities and describe ways to bridge the gap for eager general practitioners who would like to know more. CME Credit (requires free sign up): Link Coming Soon! References: Bonvicini, K. A. (2017). LGBT healthcare disparities: What progress have we made? Patient Education and Counseling, 100(12), 2357–2361. https://doi.org/10.1016/j.pec.2017.06.003 Fish, J. N. (2020). Future directions in understanding and addressing mental health among LGBTQ youth. Journal of Clinical Child & Adolescent Psychology, 49(6), 943–956. https://doi.org/10.1080/15374416.2020.1815207 Nowaskie, D. Z., & Patel, A. U. (2020). How much is needed? patient exposure and curricular education on medical students' LGBT cultural competency. BMC Medical Education, 20(1). https://doi.org/10.1186/s12909-020-02381-1 Ormiston, C. K., & Williams, F. (2021). LGBTQ youth mental health during COVID-19: Unmet needs in public health and policy. The Lancet, 399(10324), 501–503. https://doi.org/10.1016/s0140-6736(21)02872-5 Reisman, T., & Goldstein, Z. (2018). Case report: Induced lactation in a transgender woman. Transgender Health, 3(1), 24–26. https://doi.org/10.1089/trgh.2017.0044 Reisner, S. L., Bradford, J., Hopwood, R., Gonzalez, A., Makadon, H., Todisco, D., Cavanaugh, T., VanDerwarker, R., Grasso, C., Zaslow, S., Boswell, S. L., & Mayer, K. (2015). Comprehensive Transgender Healthcare: The gender affirming clinical and public health model of Fenway Health. Journal of Urban Health, 92(3), 584–592. https://doi.org/10.1007/s11524-015-9947-2 Underman, K., Giffort, D., Hyderi, A., & Hirshfield, L. E. (2016). Transgender Health: A standardized patient case for advanced clerkship students. MedEdPORTAL. https://doi.org/10.15766/mep_2374-8265.10518 Wamboldt, R., Shuster, S., & Sidhu, B. S. (2021). Lactation induction in a transgender woman wanting to breastfeed: Case report. The Journal of Clinical Endocrinology & Metabolism, 106(5). https://doi.org/10.1210/clinem/dgaa976 Wylie, K., Knudson, G., Khan, S. I., Bonierbale, M., Watanyusakul, S., & Baral, S. (2016). Serving transgender people: Clinical Care Considerations and Service Delivery Models in transgender health. The Lancet, 388(10042), 401–411. https://doi.org/10.1016/s0140-6736(16)00682-6 The Williams Institute at UCLA School of Law. (2023, July 10). How many adults and youth identify as transgender in the United States? - Williams Institute. Williams Institute. https://williamsinstitute.law.ucla.edu/publications/trans-adults-united-states/ https://implicit.harvard.edu/implicit/takeatest.html Coleman E, Radix AE, Bouman WP, et al. Standards of Care for the Health of Transgender and Gender Diverse People, Version 8. Int J Transgend Health. 2022;23(Suppl 1):S1-S259. Published 2022 Sep 6. doi:10.1080/26895269.2022.2100644 https://pflag.org/ thetrevorproject.org

On episode 488 of The Nurse Keith Show nursing and healthcare career podcast, Keith interviews Thomas George, DNP, APRN, FNP-C, NASM-CPT, a family nurse practitioner specializing in the treatment of obesity. In the course of their conversation, Keith and Dr. George discuss obesity as a chronic disease of pandemic proportions, current treatment strategies, the concept of "food noise", the latest scientific evidence, and much more. Excellent resources shared by Dr. George include the Consensus Statement on Obesity as a Disease by the Stop Obesity Alliance; the consensus statement by the the American Association of Clinical Endocrinology; an informative article about "food noise"; the Obesity Action Coalition, and the Obesity Medicine Association. Dr. Thomas George is a family nurse practitioner and assistant professor at Frontier Nursing University, and the Clinic Director and obesity specialist and business consultant for Wellspring Weight and Wellness, a new startup in rural SE Idaho. Dr. George chairs the Obesity Medicine Association's CME Committee, and holds a certificate and advanced education in obesity medicine from the Obesity Medicine Association, and a certificate in primary care obesity management from the Obesity Society. He is a certified personal trainer and weight loss specialist with the National Academy of Sports Medicine, and he himself is a person living with obesity. Connect with Thomas George: Wellspring Weight and Wellness LinkedIn Contact Nurse Keith about holistic career coaching to elevate your nursing and healthcare career at NurseKeith.com. Keith also offers services as a motivational and keynote speaker and freelance nurse writer. You can always find Keith on LinkedIn. Are you looking for a novel way to empower your career and move forward in life? Keith's wife, Shada McKenzie, is a gifted astrologer and reader of the tarot who combines ancient and modern techniques to provide valuable insights into your motivations, aspirations, and life trajectory, and she offers listeners of The Nurse Keith Show a 10% discount on their first consultation. Contact Shada at TheCircelandtheDot.com or shada@thecircleandthedot.com.

High Fructose Corn Syrup's Profits over Health:  Richard Gale & Gary Null PhD Progressive Radio Network, July 24, 2024 There is an unseen culprit hiding in the shadows. It is a toxic poison contained in many of the foods and beverages that we commonly eat. A toxin that has been implicated in causing cancer, diabetes, heart disease, lowered cognitive function, addiction, depression, and obesity. The magicians and alchemists of the corporate food industry have cleverly disguised this ingredient and sing its praises.  If you are waiting for mainstream media to undertake an in-depth investigative report on this topic you will be waiting a long time. Back in 2015 Tufts University's department of nutritional sciences conducted a study published by the American Heart Association that documented the annual rates of global deaths directly due to over-consumption of beverages with high sugar content. The results estimated that 184,000 adults die annually from sugary drinks.  Dr. Gitanjali at Tufts analyzed data documenting sugar-related deaths across 51 countries between 1980 and 2010.  Deaths were compiled according to cardiovascular disease, diabetes and various cancers. Based upon the data, the study concluded that sugar contributed to 45,000 annual deaths from cardiovascular disease, 13,000 deaths from diabetic complications, and 6,450 deaths related to cancer.  Credit Suisse's Research Institute published a scathing report that brought sugar's health risks into sharper focus.  The study revealed that upward to 40% of American healthcare expenditures could be directly tied to overconsumption of sugar in the average American diet.  Today, the US' national addiction to sugar contributes to $1 trillion in healthcare costs annually, which includes coronary heart disease, diabetes and metabolic syndrome. There are numerous studies published in reliable peer-reviewed medical journals associating sugar with each of these life threatening diseases. As far back as 1971, I began writing about the hazards of sugar. In 2002, my documentary Seven Steps to Perfect Health was premiered on PBS stations. During a special appearance on one station's fund drive, I poured sugar out of a bag. The amount I poured equaled the number of teaspoons that an average American teenager consumes daily. My general counsel, David Slater, verified the quantity by proper measurement according to scientific food and diet data.  After the initial airing of this special, I was informed by the station's program director that they could not rebroadcast the performance, even though it was the most successful program during the fund drive. I was informed that the station had received harsh criticism from the sugar industry. The program director explained that the information I presented about sugar's dangers, even though I provided full scientific verification of the facts, ran up against the president of the station board Sharon Rockefeller. I was told she had received a phone call from a sugar-lobbying group representing soft drink makers and sugar manufacturers.  Therefore the station made the decision to pull my program. I was never asked to return to the station. Not surprisingly, a subsequent investigation revealed Sharon Rockefeller sat on Pepsi's board at the time, one of America's largest manufacturers of sweetened soft drinks.    That was my first personal encounter with the political forces supporting sugar. I wrote letters to the sugar industry, the station board and Sharon Rockefeller contesting their suppression of my program and their claim that sugar was unrelated to the declining health of Americans. They were presented with dozens of peer-reviewed studies. However in recent decades, the sweetener industry has undergone a dramatic transformation with the introduction and widespread adoption of high fructose corn syrup (HFCS) throughout our food system. This shift from traditional cane sugar, which dominated my criticism earlier, to fructose corn sugars has led to deep human health and environmental concerns due to its economic benefits for food manufacturers.  High fructose corn syrup was developed in the late 1960s by Japanese scientists who discovered a method to convert glucose from cornstarch into fructose using enzymes. This innovation was spurred by the need to find a cheaper and more versatile sweetener as an alternative to the more labor-intensive production of traditional cane sugar. HFCS is made by milling corn to produce cornstarch. The starch is then hydrolyzed into glucose by adding the enzyme alpha-amylase. Finally the glucose is further processed into fructose. The result is a syrup that typically contains 42-55 percent fructose, with the rest being glucose. Some methods can produce fructose as high as 90 percent.  Today, HFCS production has been so optimized that it has become the most cost-effective and efficient means to produce sweeteners. Monsanto's genetically modified Round-Up Ready corn, enabling the use of more toxic herbicides and pesticides, has now made HFCS the cornerstone of the sugar industry.  However, the shift to HFCS has been fundamentally driven by economics and the agro-chemical industry and has absolutely nothing to do with creating a healthier sugar.  Since corn is one of the most extensively cultivated crops in the United States, which is heavily subsidized by the government, it has provided an enormous, inexpensive supply of the raw material needed for HFCS production. In addition, the enzymatic conversion process can result in a high yield of sweetener from a relatively small amount of corn.  HFCS is now a ubiquitous ingredient that permeates our entire modern food supply. Starting in the 1980s, the introduction of HFCS has gradually displaced traditional sweeteners such as natural cane sugar, glucose and honey. According to the USDA, HFCS can cost up to 50% less than cane and other traditional sugars. This cost differential is particularly significant in industries where sweeteners constitute a major portion of production costs such as in soft drinks, artificial fruit juices, sweet baked goods, snack foods and candy, breakfast cereals, condiments and sauces, sweetened dairy products such as yoghurt and ice cream, and a large variety of processed canned and prepared meals. A study published in American Journal of Clinical Nutrition found that HFCS accounts for over 40% increase of caloric sweeteners added to foods and beverages. Having a purview of the distribution of different sugars in the American diet helps to illustrate the dominance of HFCS in the food system. Approximately 45 percent of added sugars in the American diet come from HFCS and an additional 2 percent from pure fructose. Between 35-40 percent of sweeteners derive from sucrose, the common table sugar made from sugarcane and sugar beets -- the latter now being genetically modified. The production process involves crushing the plant material to extract the juice, which is then purified, concentrated, and crystallized to produce table sugar.  Not to be confused with HFCS, corn syrup is largely glucose and represents about 10-15 percent of the nation's sugar intake. It is the most common sugar used in baked goods and candy. Lactose and galactose each account for about 4-5 percent of consumed sugars. However they are typically not added sugars to foods but naturally present in all dairy products.  Finally, honey, which at one time was a common food ingredient, today only accounts for about 1-2 percent of sweeteners.  Moreover, according to FDA testing, a lot of commercial honey found in grocery stores has been adulterated with HFCS and other sweeteners, such sucrose derived from cane and GMO beet sugars and artificial honey-flavored imitators.  A general estimate is that 20-30 percent of honey sold is impure.  Back in the 1970s and 1980s when I frequently railed publicly against the sugar industry and the health risks of processed table sugar that then completely dominated the food industry, I would never have imagined that sucrose would be gradually replaced by HFCS. This replacement accelerated after the emergence of genetically modified (GM) corn. As noted above, the vast majority of HFCS produced in the United States, the world's larger corn producer globally, is derived from genetically modified (GM) corn. Estimates suggest that around 85-90% of the corn grown in the U.S. is genetically modified. Therefore it is reasonable to infer that approximately 85-90% of HFCS is derived from GM corn. As many court cases and exposes of corruption in the agro-chemical industry have cone to light, GM corn has dire implications for the production and consumption of HFCS, especially considering the associated health risks linked to the use of toxic herbicides such as glyphosate. Research has linked glyphosate to various health issues, including cancer. A decade ago, the International Agency for Research on Cancer (IARC) classified glyphosate as a "probable human carcinogen"; today, it is no longer probable but a medical fact. Several studies have detected glyphosate residues in food products containing HFCS. A study published in Environmental Health found glyphosate residues in a variety of food products, highlighting the widespread contamination of the food supply with this herbicide. In addition to glyphosate's carcinogenic potential, the toxin has also been shown to disrupt endocrine function and it has been implicated in gut dysbiosis, an imbalance in the gut microbiome. This disruption can lead to a range of health problems, including inflammatory bowel disease (IBD) and other gastrointestinal disorders. Research published in Current Microbiology indicates that glyphosate exposure can alter the composition of the gut microbiota, leading to adverse health outcomes. HFCS and traditional sugars like table sugar differ significantly in their composition and metabolic effects. Sucrose is a disaccharide composed of equal parts glucose and fructose, while HFCS is a mixture of free glucose and fructose, with the fructose content higher than that in sucrose. This difference in composition affects how the body metabolizes these sugars. Briefly, HFCS poses more serious health risks than sucrose. The free fructose in HFCS is absorbed more rapidly than the bound fructose in sucrose, leading to quicker spikes in blood sugar and insulin levels. In addition, the high fructose content in HFCS places a greater burden on the liver, leading to increased fat production and storage, contributing to fatty liver disease and metabolic disorders. In contrast, the balanced glucose-fructose composition of sucrose is metabolized more evenly, posing lower risks. However, it is crucial to realize that excessive or even moderate consumption of any form of sugar can be detrimental to health. Extensive research has linked the consumption of HFCS to a range of adverse health effects. Key among these is metabolic disorders and cardiovascular diseases. A study published in the Journal of Clinical Endocrinology & Metabolism found that high consumption of HFCS is associated with an increased risk of developing metabolic syndrome, which includes conditions such as obesity, insulin resistance, hypertension, and dyslipidemia. These conditions collectively elevate the risk of heart disease and stroke. HFCS has been directly implicated in America's obesity epidemic due to its high fructose content, which is metabolized differently than glucose. Fructose is primarily processed in the liver, where it can be converted into fat more readily than glucose. This process can lead to increased fat accumulation and insulin resistance, both of which are risk factors for obesity and type 2 diabetes. A study in the American Journal of Clinical Nutrition highlighted that high HFCS consumption is correlated with an increased risk of obesity and diabetes, particularly in children and adolescents. HFCS intake also leads to non-alcoholic fatty liver disease (NAFLD). Unlike glucose, which is metabolized by all cells in the body, fructose is metabolized almost entirely in the liver. High levels of fructose overwhelms the liver's capacity to process it, leading to fat accumulation and liver damage. Research published in Hepatology has shown a strong correlation between HFCS consumption and the progression to more severe liver diseases, such as cirrhosis and liver cancer. Recent evidence reveals that HFCS has detrimental effects on cognitive function and mental health. Studies indicate that fructose impairs insulin signaling in the brain, which is crucial for maintaining cognitive functions. A study in the Journal of Physiology found that high-fructose diets can lead to insulin resistance in the brain, potentially increasing the risk of neurodegenerative diseases like Alzheimer's. Additionally, high sugar diets, including those high in HFCS, have been linked to mood disorders, such as depression and anxiety, as detailed in a review in Nature Reviews Neuroscience. HFCS and other fructose-rich sugars can have profound adverse effects on the gut and digestive system. These sugars are known to disrupt the normal functioning of the gastrointestinal tract, contributing to various digestive disorders and altering the gut microbiome. Fructose, unlike glucose, is not directly absorbed by the body. It requires a specific transporter, GLUT5, to be taken up by the intestinal cells. Fructose interferes with these transporters, leading to malabsorption. Unabsorbed fructose travels to the large intestine, where it undergoes fermentation by gut bacteria. This process produces gases such as hydrogen, carbon dioxide, and methane, which cause bloating, gas, and abdominal pain leading to malabsorption and the intestine's inability to absorb fructose efficiently. The gut microbiome, a complex community of trillions of microorganisms living in the digestive tract, is crucial for maintaining digestive health, immune function, and overall well-being. High intake of fructose negatively affects this delicate balance. Studies have shown that diets high in fructose can lead to an imbalance in the gut microbiota composition. This imbalance is characterized by a decrease in beneficial bacteria such as Bifidobacteria and Lactobacilli and an increase in harmful bacteria like Clostridia and Enterobacteria.  A study published in The American Journal of Clinical Nutrition found that high fructose levels increase intestinal permeability, also known as "leaky gut." This condition allows harmful substances, such as toxins and bacteria, to pass from the gut into the bloodstream, triggering inflammation and contributing to the development of various diseases, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Inflammatory bowel disease, which includes conditions like Crohn's disease and ulcerative colitis, is exacerbated by promoting inflammation and altering the gut microbiota. A study in the journal Gut reported that reducing fructose intake improved symptoms in individuals with IBS, suggesting a direct link between fructose consumption and IBS symptom severity. Finally we need to also consider the catastrophic effects of HFCS on children. Children are particularly vulnerable to the health risks associated with HFCS due to their higher consumption levels relative to their body weight. According to data from the CDC, the average American child consumes approximately 12-16 teaspoons of added sugars per day, a significant portion of which comes from HFCS. This high intake is largely driven by the consumption of sweetened beverages, snacks, and processed foods that are marketed specifically to children. The high consumption of HFCS among children is a major contributor to the rising rates of childhood obesity and metabolic disorders. Studies have shown that children who consume high levels of sugary beverages and snacks are more likely to develop obesity, insulin resistance, and type 2 diabetes. A study published in Pediatrics found that children who consume sugary drinks daily are at a significantly higher risk of developing obesity compared to those who consume them less frequently. There is also growing concern about the impact of HFCS on children's cognitive development and behavior. High sugar diets have been linked to attention deficit hyperactivity disorder (ADHD) and other behavioral issues in children. A study in the Journal of Attention Disorders found that excessive sugar consumption, including HFCS, exacerbates symptoms of ADHD and impair cognitive functions such as memory and learning. A deeper look at the politics of the sugar industry reveals that huge sums are being doled out by the government to support and subsidize sugar companies. Writing for the Wall Street Journal, health journalist Alexandra Wexler explains that American taxpayers are currently responsible for shelling out $280 million to cover the cost of loans from the USDA which sugar producers are unable to pay back. Given the undeniable evidence demonstrating the toxicity of HFCS and other commercial sugars and their enormous toll on the wellbeing of Americans, why is it that our health agencies and elected officials are not calling for an urgent overhaul of existing policies, which graciously support the domestic sugar industry to poison the population? Where is the outrage over bailing out the purveyors of what is likely the most dangerous staple in the American diet? For our answers we must follow the money-trail.

Iago Jooooorge, Marcela Belleza e Eduarda Bauer atualizam o episódio 102 de osteoporose em 5 clinicagens: como avaliar o risco de fratura? Como e quando iniciar o ⁠⁠tratamento após fratura? Como continuar o tratamento depois dos medicamentos anabólicos? ⁠⁠Quando e como acompanhar as "férias" de bisfosfonatos? Como tratar homens com osteoporose?  Vote no TdC no prêmio Melhores Podcasts do Brasil (prêmio MPB). Estamos na categoria Ciência! https://www.premiompb.com.br/ Referências: Site da ABRASSO - https://abrasso.org.br/ Frax Plus https://www.fraxplus.org/frax-plus  https://www.tadeclinicagem.com.br/guia/198/tratamento-farmacologico-de-osteoporose-primaria/  Richard Eastell, Clifford J Rosen, Dennis M Black, Angela M Cheung, M Hassan Murad, Dolores Shoback, Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 5, May 2019, Pages 1595–1622, https://doi.org/10.1210/jc.2019-00221 Silva BC, Madeira M, d'Alva CB, et al. Definition and management of very high fracture risk in women with postmenopausal osteoporosis: a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Association of Bone Assessment and Metabolism (ABRASSO). Arch Endocrinol Metab. 2022;66(5):591-603. doi:10.20945/2359-3997000000522 Radominski SC, Bernardo W, Paula AP, et al. Brazilian guidelines for the diagnosis and treatment of postmenopausal osteoporosis. Rev Bras Reumatol Engl Ed. 2017;57 Suppl 2:452-466. doi:10.1016/j.rbre.2017.07.001 Gregson, C.L., Armstrong, D.J., Bowden, J. et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 17, 58 (2022). https://doi.org/10.1007/s11657-022-01061-5  El Miedany, Y., Toth, M., Elwakil, W. et al. Post-Fracture Care Program: Pharmacological Treatment of Osteoporosis in Older Adults with Fragility Fractures. Curr Osteoporos Rep 21, 472–484 (2023). https://doi.org/10.1007/s11914-023-00791-w Wang CY, Fu SH, Yang RS, Chen LK, Shen LJ, Hsiao FY. Timing of anti-osteoporosis medications initiation after a hip fracture affects the risk of subsequent fracture: A nationwide cohort study. Bone. 2020;138:115452. doi:10.1016/j.bone.2020.115452 Camacho PM, Petak SM, Binkley N, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS-2020 UPDATE. Endocr Pract. 2020;26(Suppl 1):1-46. doi:10.4158/GL-2020-0524SUPPL Ramchand SK, Leder BZ. Sequential Therapy for the Long-Term Treatment of Postmenopausal Osteoporosis. J Clin Endocrinol Metab. 2024;109(2):303-311. doi:10.1210/clinem/dgad496 Chandran M. The why and how of sequential and combination therapy in osteoporosis. A review of the current evidence. Arch Endocrinol Metab. 2022;66(5):724-738. doi:10.20945/2359-3997000000564

Episode Title: 29. How Circadian Rhythms Can Transform Your Hormonal Health Host: Lacy Lain, The Functional Medicine Woman Episode Summary: In this episode of Functional Medicine for Women, Lacy Lain delves into the critical connection between women's functional health and circadian medicine. She discusses how circadian rhythms impact mood, anxiety, and depression, potentially leading to HPA axis dysfunction and hormonal imbalances. Lacy shares practical tips to help reset your circadian rhythm and improve overall well-being. Key Points: Understanding Circadian Rhythm: Circadian rhythms are influenced by external cues like light and darkness. Morning sunlight exposure can improve sleep quality and mood. Hormonal Insights: Melatonin: Produced in response to darkness; optimal production requires morning sunlight exposure. Cortisol: The stress hormone, follows a daily rhythm; peaks in the morning and levels out during the day. Imbalances in melatonin or cortisol can lead to poor sleep quality, chronic fatigue, and anxiety. Impact of Lifestyle Choices: Irregular sleep patterns, shift work, and late-night screen use can disrupt circadian rhythm. Simple changes like establishing a bedtime routine and reducing screen time can improve circadian health. Circadian Rhythm and Mental Health: Disruptions in circadian rhythms are linked to mood disorders, anxiety, and depression. Studies highlight the importance of maintaining regular sleep patterns and light exposure. Practical Tips for Better Sleep and Hormonal Balance: Set a consistent sleep schedule: Go to bed and wake up at the same time every day, even on weekends. Reduce exposure to artificial light at night: Use blue light filters or dim lights in the evening. Spend time outside in natural light: Aim for at least 30 minutes of sunlight exposure daily, preferably before 10 a.m. Additional Lifestyle Factors: Diet and Exercise: A balanced diet and regular physical activity support healthy circadian rhythms. Stress Resilience: Building stress resilience through methods like cold showers or cold plunges (under guidance) can enhance emotional balance. HPA Axis and Hormonal Health: Chronic circadian disruption and elevated cortisol levels can lead to HPA axis dysfunction. This dysfunction affects thyroid function and reproductive health, causing symptoms like fatigue, weight gain, and irregular menstrual cycles. Personal Experience and Insights: Lacy shares her personal journey with hormonal imbalances and how functional medicine helped her achieve regular cycles and better health. Actionable Takeaway: Start improving your circadian rhythm today by setting a consistent sleep schedule, reducing exposure to artificial light at night, and spending time outside in natural light. Remember, small consistent actions lead to long-term health benefits. Resources Mentioned: The Lancet Psychiatry Study on Circadian Rhythms and Mood Disorders Journal of Clinical Endocrinology and Metabolism Study on Stress and Hormonal Imbalances Call to Action: If you found today's episode helpful, please share it with others who might benefit. Don't forget to subscribe and leave a review. Visit functionalhealthforwomen.com to join the free forever membership and start your journey toward optimal wellness today. Thank you for joining us on this journey to better health. Stay tuned for our next episode, where we dive deeper into functional health topics. Until next time, take care and keep prioritizing your health. Connect with Lacy: Social Profiles: Follow Lacy Lain on Instagram for daily tips and updates on functional health and holistic wellness. Join the FREE Holistic Health Hub Membership here. Disclaimer: Our life and health coaches do not diagnose, treat, prevent, or cure any disease or condition. Nothing we share with our clients is intended to substitute for the advice, treatment, or diagnosis of a qualified licensed physician. Lacy Lain, FMCHC may not make any medical diagnoses or claim, nor substitute for your personal physician's care. It is the role of Lacy Lain and her Practitioners to partner with their clients to provide ongoing support and accountability in an opt-in model of self-care and should be done under the supervision of a licensed physician. These platforms share personal experiences and provides education. Interaction on these platforms does not constitute a doctor/patient relationship.

In this episode, Charmaine, a seasoned dietitian, and Ghalia, an expert coach in the Reversing Diabetes Program, unravel the complexities of managing diabetes in the digital age. Navigating through the overwhelming and often conflicting information online, they shed light on scientifically backed blood glucose lowering hacks that actually work!Join the journey as they share two commonly overlooked factors that can help you progress further in your journey towards reversing diabetes!If you are looking to know more about what you can do starting from today to improve your insulin sensitivity and metabolic health so that you can reverse diabetes, then this podcast episode is a must-listen!ReferencesSpiegel, K., Leproult, R., & Van Cauter, E. (1999). Impact of sleep debt on metabolic and endocrine function. The Lancet, 354(9188), 1435-1439.Buxton, O. M., Pavlova, M., Reid, E. W., Wang, W., Simonson, D. C., & Adler, G. K. (2010). Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes, 59(9), 2126-2133.Spiegel, K., Tasali, E., Penev, P., & Van Cauter, E. (2004). Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141(11), 846-850.Chaput, J. P., Després, J. P., Bouchard, C., & Tremblay, A. (2007). Short sleep duration is associated with reduced leptin levels, elevated ghrelin levels, and increased body mass index. Sleep, 30(11), 1429-1437.Donga, E., Van Dijk, M., Van Dijk, J. G., Biermasz, N. R., Lammers, G. J., van Kralingen, K. W., ... & Romijn, J. A. (2010). A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. Journal of Clinical Endocrinology & Metabolism, 95(6), 2963-2968.Leproult, R., Copinschi, G., Buxton, O., & Van Cauter, E. (1997). Sleep loss results in an elevation of cortisol levels the next evening. Sleep, 20(10), 865-870.Rizza, R. A. (2010). Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: Implications for therapy. Diabetes, 59(11), 2697-2707.Rosmond, R., Dallman, M. F., & Björntorp, P. (1998). Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. Journal of Clinical Endocrinology & Metabolism, 83(6), 1853-1859.Black, P. H. (2003). The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain, Behavior, and Immunity, 17(5), 350-364.Purnell, J. Q., Kahn, S. E., Samuels, M. H., Brandon, D., Loriaux, D. L., & Schwartz, R. S. (2009). Enhanced cortisol production rates, free cortisol, and 11β-HSD-1 expression correlate with visceral fat and insulin resistance in men: Effect of weight loss. American Journal of Physiology-Endocrinology and Metabolism, 296(2), E351-E357.Adam, T. C., & Epel, E. S. (2007). Stress, eating and the reward system. Physiology & Behavior, 91(4), 449-458.   12. Choi, J. H., Joseph, L., & Pilote, L. (2013). Obesity and C-reactive protein in various populations: A systematic review and meta-analysis. Obesity Reviews, 14(3), 232-244.⇰FREE WEBINAR TRAINING & OTHER LINKS: https://stan.store/reversingdiabetesrevolutionMy name is Charmaine and I'm the registered dietitian who helps people reverse Typ

In this episode, Po and Dr. Rak welcome Dr. Gebre Nida, MD, FACE, DipABLM, whose remarkable journey from the rugged terrains of rural Ethiopia to the forefront of lifestyle medicine in North Carolina epitomizes resilience and transformative care. Born in a village without electricity, Dr. Nida walked hours to school daily, a testament to his commitment to education and betterment. Now a triple board-certified endocrinologist, he integrates lifestyle medicine into his practice, profoundly impacting patients battling chronic diseases like type 2 diabetes. In this episode, Dr. Nida shares his personal story and professional insights, demonstrating how deep empathy and dedicated care can revolutionize healthcare. Listen as we explore how overcoming extreme obstacles equipped him to change lives through a unique blend of medicine and compassion. Takeaways Perseverance and determination are key to overcoming challenges and achieving success. Education is a powerful tool that can transform lives and open doors to opportunities. Community support and mentorship play a crucial role in helping individuals reach their full potential. Gratitude and a positive mindset can help navigate difficult circumstances and fuel personal growth. Lifestyle medicine is a powerful approach to healthcare that focuses on empowering patients to take control of their health through healthier living. Lowering systemic inflammation is key to healing the body and preventing chronic diseases. Prioritizing self-care, including exercise and a healthy diet, is essential for healthcare professionals to lead by example and effectively promote lifestyle medicine. Addressing chronic diseases requires a holistic approach that includes diet, exercise, stress management, and social connections. Timestamps: 00:00 A Glimpse into a Challenging Childhood 00:56 Meeting Gebre: A Journey of Transformation 06:15 Gebre's Origin Story: From Rural Ethiopia to Medical Excellence 08:18 The Struggles and Triumphs of Pursuing Education 12:25 The Journey to Becoming a Board Certified Physician in the U.S. 37:57 Embracing a New Perspective on Medicine and Health 45:30 Challenging the Status Quo: A Doctor's Transformation 51:20 Revolutionizing Diabetes Management with Lifestyle Medicine 52:03 The Power of 10-Minute Consultations 52:56 Preparing for Patient Encounters: A Personalized Approach 55:13 Empowering Patients in Rural North Carolina 55:49 Overcoming Systemic Resistance to Lifestyle Medicine 01:04:25 Personal Journey: From Burnout to Empowerment 01:11:09 The Impact of Lifestyle Medicine Beyond the Clinic 01:11:47 Balancing Professional Commitment and Self-Care 01:25:26 The Future of Medicine: A Call to Action 01:28:33 Closing Thoughts: Food as the Foundation of Health Online Platforms: Connect with Dr. Nida on LinkedIn Guest Bio: Gebreselassie (Gebre) Nida, MD, is a full-time general endocrinology practitioner in North Carolina. He is board-certified in internal medicine, endocrinology, and lifestyle medicine. He was born and raised in Ethiopia, where he attended undergraduate and medical school. He did his residency in internal medicine and a fellowship in endocrinology, diabetes, and metabolism in Michigan. Dr. Nida always attempts to provide compassionate, comprehensive, patient-centered assistance in patients' healthcare decisions. He practices evidence-based medicine and, as much as he can, engages patients in sometimes serious discussions to clear up myths and misinformation. Dr. Nida is a member of many medical societies, including the American Diabetes Association, American Association of Clinical Endocrinology, North Carolina Medical Society, and American College of Lifestyle Medicine. He is the chair of the Cone Health lifestyle medicine steering committee. Follow @thehealthfeast on IG and YT for more. The Health Feast is available where you get podcasts and thehealthfeast.com. Have a question or comment for Dr. Rak and Po? You can submit them on our website https://www.thehealthfeast.com Disclaimer: The Health Feast is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. As with any changes affecting your health, we recommend and encourage you to consult your medical doctor or other qualified healthcare professionals before making lifestyle changes. The opinions expressed are our own and do not necessarily reflect the views of our employers.

We all know that a sedentary lifestyle is not healthy for anyone, but just how strongly is physical activity connected to lipid levels in childhood? Host Aaron Lohr talks with Andrew Agbaje, MD, PhD, a physician and pediatric clinical epidemiologist at the University of Eastern Finland. He has authored a study recently published in The Journal of Clinical Endocrinology & Metabolism titled, “Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study.” Show notes are available at https://www.endocrine.org/podcast/enp83-sedentary-time-and-physical-activity-effects-on-childhood-lipid-levels — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

One of the most hot button topics in today's nutrition landscape is the debate between plant-based and animal-based sources. While there are many perspectives and lenses on which to view this topic including environment, ethical, and spiritual, I want to address this issue from a nutritional standpoint and what the research shows is best for our health, hormones, and body composition. We'll also discuss the role of beauty and the bodybuilding industry, complete proteins, why I love my air fryer, and more!     Time Stamps:   (1:32) Animal vs Plant Based Diets (3:40) Plant Based Diet Benefits (6:02) Plant Based Products (7:43) Beauty and Bodybuilding Industry (10:05) What is a Complete Protein? (12:48) The Invention of the Air Fryer (13:04) Environmental Considerations (17:35) Please Subscribe, Rate, and Follow Me ----------  Resources Used:   Journal of the American Heart Association: "Plant‐Based Diets Are Associated With a Lower Risk of Incident Cardiovascular Disease." Journal of Nutrition and Metabolism: "The Importance of Bioavailable Iron in Meat." Nutrients: "Health Benefits of Fruits and Vegetables." American Journal of Clinical Nutrition: "Micronutrient Status in Omnivores, Vegetarians, and Vegans in Switzerland." Journal of Clinical Endocrinology and Metabolism: "Effects of Phytoestrogens on Estrogen Metabolism." International Osteoporosis Foundation: "Nutrition and Bone Health." National Institutes of Health, Office of Dietary Supplements: "Vitamin B12 Fact Sheet for Health Professionals." Journal of the American College of Nutrition: "Iron and Zinc Bioavailability in Humans: A Review." Public Health Nutrition: "Health and nutritional aspects of sustainable diet strategies and their association with environmental impacts: a global modeling analysis with country-level detail." Academy of Nutrition and Dietetics: "Position of the Academy of Nutrition and Dietetics: Vegetarian Diets." Menopause: "Omega-3 fatty acids and inflammatory processes: from molecules to man." ----------  Follow Me On Instagram - https://www.instagram.com/sarahfechter.ifbbpro/   Check Out My Website - https://www.sarahfechter.com ----------  This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, other professional health care services, or any professional practice of any kind. Any reliance on the information provided in this Podcast is done at your own risk and Sarah Fechter Fitness LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual use of, reference to, reliance on, or inability to use, this Podcast or the information presented in this Podcast. All contents and design for this Podcast are owned by Sarah Fechter Fitness LLC. Always consult your professional team before beginning any exercise or nutrition program.

Have you ever wondered what drives your decisions, what fuels your motivation to stick to a workout plan, or why certain foods seem irresistible? The answer might surprise you – it's all about a powerful brain chemical called dopamine. This neurotransmitter plays a crucial role in our everyday behavior and choices, often without us even realizing it. In this article, we'll delve into how dopamine influences your adherence to exercise and nutrition programs, what causes its levels to fluctuate, and, most importantly, what you can do to optimize dopamine levels for better health and well-being. As a health and fitness enthusiast, you might already know that maintaining a healthy lifestyle isn't just about willpower – it's about understanding and working with your body's natural processes. That's what we aim to uncover here. So, whether you're looking to boost your motivation, improve your mood, or simply understand your body better, you're in the right place. Let's dive into the world of dopamine and discover how this crucial neurotransmitter can be your ally in achieving your health and fitness goals. What is Dopamine? - Understanding the Basics Dopamine, often referred to as the "feel-good" neurotransmitter, is a chemical messenger vital for conveying signals in the brain. It's produced in various parts of the brain, including the substantia nigra and the ventral tegmental area.Schultz, W. (2007). Multiple dopamine functions at different time courses. Annual Review of Neuroscience, 30, 259-288. But dopamine is more than just a messenger of pleasure; it's a critical component in your ability to think, plan, focus, and find things interesting. The production of dopamine starts with the amino acid tyrosine. Tyrosine undergoes a series of transformations, eventually becoming dopamine. Once produced, dopamine travels through different pathways in the brain, each influencing various aspects of behavior and physical function.Wise, R. A. (2004). Dopamine, learning and motivation. Nature Reviews Neuroscience, 5(6), 483-494. Interestingly, dopamine is not just confined to the brain. A substantial portion is also produced in the gut. This gut-derived dopamine is pivotal in regulating gastrointestinal motility and ensuring the proper functioning of the digestive system.Eisenhofer, G., Aneman, A., Friberg, P., Hooper, D., Fåndriks, L., Lonroth, H., … & Lundberg, J. (1997). Substantial production of dopamine in the human gastrointestinal tract. Journal of Clinical Endocrinology & Metabolism, 82(11), 3864-3871 The gut-brain axis, a communication network linking the gut and the brain, suggests that the dopamine produced in the gut could also have indirect effects on mood and behavior.Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2), 203. Dopamine doesn't work in isolation. It interacts with neurotransmitters like serotonin and norepinephrine, creating a delicate balance affecting everything from your mood to your motor skills.Carlsson, A. (1959). The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacological Reviews, 11(2), 490-493. In general, dopamine is central to motivating behavior by signaling the anticipation of a reward. It's involved in various functions, including memory, attention, mood, learning, and even motor control.Berridge, K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Research Reviews, 28(3), 309-369. Dopamine's Influence on Exercise and Nutrition Adherence As we've seen, dopamine is a key player in the brain's reward system. But how exactly does this translate to our exercise and nutrition habits? Exercise-induced dopamine release creates a feedback loop in your brain. When you exercise,

According to ACOG's CO 773 from 2019, “Currently, serum antimüllerian hormone levels are not part of the accepted diagnostic criteria for polycystic ovary syndrome (PCOS)”. But medicine moves fast, and that statement is no longer valid, at least it isn't valid from the ASRM July 2023 Standpoint. Yep, once considered experimental, AMH has now entered the PCOS diagnostic algorithm. Nonetheless, some important limitations and facts must be understood for its use in this way. In this episode, we will highlight the recommendations from the 2023 international, evidence-based guideline for the assessment and management of polycystic ovary syndrome, focusing on the role of AMH. We will also discuss the condition in adolescents and why this diagnosis is DIFFERENT in this group, and the update to the number of follicles per ovary (FNPO) recommended for the diagnosis. This guideline has been co-published in Fertility and Sterility, Human Reproduction, European Journal of Endocrinology, and The Journal of Clinical Endocrinology and Metabolism.

"I turned 40 and my hormones..." I've heard something like this over and over. Age takes the blame for hormone-related health problems, but is it really age that's to blame? No, it's one's nutrition and lifestyle choices. Some people still own pristine cars from the 50s and 60s because of the way they've cared for them. Others own cars that are just a few years old and look like junkers. Half a lifetime of poor diet and lifestyle choices compound until your body cannot counter those choices any longer. You see and feel their effects. The good news is that your body is far more resilient than a car is. When you stop sabotaging your hormones, you can restore your health within months to a year. If you're ready to stop blaming your hormones and start taking responsibility for your habits, take a look at these 29 causes of hormone imbalances and find out which ones you need to act on beginning today. 1. Excessive Carbohydrate Consumption Before you think, "I really don't eat that many carbs," think again. Most people I've met have said that, and yet, when I ask them what they ate in the days leading up to our conversation, they realize just how much of the food they eat is carbohydrate-heavy. Excessive carbohydrate consumption causes your pancreas to secrete more insulin, which helps regulate blood sugar levels. Over time, the cells in your muscles stop listening to the constantly high levels of insulin, a condition known as insulin resistance.Wright, E., Scism-Bacon, J. L., & Glass, L. C. (2018). Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. International Journal of Clinical Practice, 60(3), 308–314. This causes your pancreas to release even more insulin, creating a vicious cycle. Insulin resistance is a precursor to conditions like type 2 diabetes and polycystic ovarian syndrome (PCOS). But that's not all. Elevated insulin levels can also impact other hormones, such as leptin, which regulates hunger.Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010). Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology & Metabolism, 21(11), 643–651. Additionally, too much insulin can increase androgens, the so-called "male hormones" that can cause issues in both men and women. To make matters worse, increased insulin often leads to the storage of visceral fat, which is hormonally active and can further exacerbate hormonal imbalances.Tchernof, A., & Després, J. P. (2013). Pathophysiology of human visceral obesity: an update. Physiological Reviews, 93(1), 359–404. 2. Not Eating Enough Protein Protein isn't just for bodybuilders; it's essential for everyone, especially when it comes to hormone health. Proteins are the building blocks of hormones, and a lack of it can directly affect the production of crucial hormones like insulin, growth hormone, and even sex hormones like estrogen and testosterone.Pasiakos, S. M. (2015). Metabolic advantages of higher protein diets and benefits of dairy foods on weight management, glycemic regulation, and bone. Journal of Food Science, 80(S1), A2–A7. Not eating enough protein can also destabilize your blood sugar levels, making your body produce excessive insulin.Belobrajdic, D. P., & Bird, A. R. (2013). The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutrition Journal, 12(1), 62. A study published in the Journal of Clinical Endocrinology & Metabolism found that low protein intake was associated with decreased thyroid hormone levels.Jung, C. H., Choi, K. M., & Jung, S. H. (2018). The relationship between protein intake and thyroid hormone. Journal of Clinical Endocrinology & Metabolism, 103(2), 626–635. Lower thyroid levels can lead to a slow metabolism, weight gain, and fatigue. Additionally, adequate protein intake influences appetite-related hormones like ghrelin and GLP-1, helping you feel full and satisfied.

What comes to mind when you think of “metabolic disease”? It seems as though terms like “metabolic disease” and “metabolic health” are everywhere in social media. Are we talking diabetes? Thyroid dysfunction? Is this just a new way to package and market the diet/weight loss industry? Is it all about the number on the scale??Today we will dive into a few facets of metabolic health, and we will focus specifically on “prediabetes”. According to the CDC:Prediabetes is a serious health condition where blood sugar levels are higher than normal, but not high enough yet to be diagnosed as type 2 diabetes. Approximately 96 million American adults—more than 1 in 3—have prediabetes. Of those with prediabetes, more than 80% don't know they have it. Prediabetes puts you at increased risk of developing type 2 diabetes, heart disease, and stroke.How can we know if we are at risk for prediabetes? Is it all genetic? Are there things we can control to reduce our risk? Are there system-based changes that can be made in the American healthcare system that can help folks improve their risk of developing metabolic disease on a large, population-based scale?Thankfully, we have our friend and renowned expert in the field of Endocrinology to help us understand more! Welcome, Greg Dodell, MD, FACE!Dr. Dodell is a board-certified Endocrinologist. He received his medical degree from Albany Medical College. He completed his internal medicine and endocrinology Fellowship at St. Luke's-Roosevelt Hospital Center, affiliated with Columbia University. He is in private practice at Central Park Endocrinology, PC. He also is active on social media ( Everything_Endocrine on IG), where he posts wonderfully helpful information about metabolic health. He supports weight-neutral healthcare, combats toxic diet culture, and is active in campaigning for legislation to end size discrimination. His testimony in February of this year at NYC City Hall helped pass a bill banning body size discrimination in the workplace, and added weight and height as protected classes under NYCs Human Rights Law!Dr. Dodell and Your Doctor Friends recommend the following resources to learn more about prediabetes and metabolic disease:The American Academy of Clinical Endocrinology website. Dr. Dodell's practice, Central Park Endocrinology website. NAAFA: National Association to Advance Fat Acceptance's research on fat bias in the news.FLARE: Fat Legal Advocacy, Rights, and Education website. DOVE'S website on supporting the movement to end body size discrimination. NYC official website covering the signage of legislation to prohibit height/weight in employment, housing, and public accommodations.For more episodes, limited edition merch, or to become a Friend of Your Doctor Friends (and more), follow this link!...

Today we look at a study from ENDO 2023 about COVID-19 exposure and weight gain in infants. Host Aaron Lohr talks with Mollie Ockene, a Clinical Research Coordinator at Massachusetts General Hospital and a co-author of the study, titled, “Accelerated Longitudinal Weight Gain Among Infants With In Utero COVID-19 Exposure.” Also, get a sneak peak at an episode of our members-only podcast Endocrine Feedback Loop which looks at a study in The Journal of Clinical Endocrinology & Metabolism about the glycemic gap in hospitalized patients with COVID. Show notes are available at https://www.endocrine.org/podcast/enp76-infants-and-in-utero-exposure-to-covid — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

Today we look at a study from ENDO 2023 about COVID-19 exposure and weight gain in infants. Host Aaron Lohr talks with Mollie Ockene, a Clinical Research Coordinator at Massachusetts General Hospital and a co-author of the study, titled, “Accelerated Longitudinal Weight Gain Among Infants With In Utero COVID-19 Exposure.” Also, get a sneak peak at an episode of our members-only podcast Endocrine Feedback Loop which looks at a study in The Journal of Clinical Endocrinology & Metabolism about the glycemic gap in hospitalized patients with COVID. For helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

We're in the midst of a testosterone crisis. Alarmingly, the average levels of this crucial male hormone have been plummeting, with one seminal study reporting a staggering 1% annual decline in average testosterone levels since the late 20th century.Travison, T. G., Araujo, A. B., O'Donnell, A. B., Kupelian, V., & McKinlay, J. B. (2007). A population-level decline in serum testosterone levels in American men. The Journal of Clinical Endocrinology & Metabolism, 92(1), 196-202. This decline isn't just a number; it's a reality affecting men's health, well-being, and quality of life. Lower testosterone levels have been linked to an increased risk of cardiovascular disease, decreased muscle mass, diminished cognitive function, and even a reduced lifespan.Araujo, A. B., Esche, G. R., Kupelian, V., O'Donnell, A. B., Travison, T. G., Williams, R. E., ... & McKinlay, J. B. (2007). Prevalence of symptomatic androgen deficiency in men. The Journal of Clinical Endocrinology & Metabolism, 92(11), 4241-4247. So, to call it a "crisis" is no exaggeration at all. You're in the right place if you're concerned about low testosterone or suspect you may be part of this growing trend. This article breaks down the 17 leading causes of low testosterone—all supported by scientific evidence. It's actionable, understandable information that you can use to take charge of your health. 1. Aging By the time you hit 30, your testosterone levels could start to decline by around 1% each year.Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001). Longitudinal effects of aging on serum total and free testosterone levels in healthy men. The Journal of Clinical Endocrinology & Metabolism, 86(2), 724-731. Why does this happen? Simply put, it's due to a slowdown in testicular function coupled with a decrease in the responsiveness to luteinizing hormone (LH). LH acts like a messenger, telling your testes to produce testosterone. As you age, this messaging system gets a bit sluggish, causing the testes to produce less testosterone.Wu, F. C., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., ... & Lean, M. E. (2008). Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2737-2745. A 1% drop might not sound like much initially, but consider this: by the time you're 50, you could be looking at a decline of 20% or more. That's significant. Lower testosterone levels can lead to diminished energy, less muscle mass, a decreased sex drive, and even mood swings. Over time, this could affect your quality of life. You can't stop the clock, but you can buffer its effects. Supplements, nutrition, and exercise can all slow the loss significantly, but an intense resistance training program is one of the most effective.Vingren, J. L., Kraemer, W. J., Ratamess, N. A., Anderson, J. M., Volek, J. S., & Maresh, C. M. (2010). Testosterone physiology in resistance exercise and training. Sports Medicine, 40(12), 1037-1053. 2. Excess Body Fat When it comes to testosterone, carrying excess weight is like a double-edged sword. On one end, body fat—especially abdominal fat—contains an enzyme called aromatase that converts testosterone into estrogen, the primary female sex hormone.Cooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S., & Hess, R. A. (2017). Estrogens in Male Physiology. Physiological reviews, 97(3), 995–1043. So the more fat you have, the more of your limited testosterone is converted into estrogen. This inevitably leads to even lower levels of free testosterone in the body. On the other end, low testosterone can lead to an increase in body fat, setting off a self-perpetuating cycle. Lower testosterone levels slow your metabolism and decrease muscle mass, making it easier to gain body fat.Saad, F., Aversa, A., Isidori, A. M., & Gooren, L. J. (2011).

Get science-based nutrition advice straight to your inbox: https://bit.ly/3ExWxCG Most of us like to have breakfast before we exercise in the morning, but what happens if we don't eat anything first? The issue goes beyond weight loss and exercise timing to involve blood sugar, insulin sensitivity, and other — perhaps unexpected — aspects of your health.In today's short episode of ZOE Science & Nutrition, Jonathan and Professor Javier Gonzalez ask: Should we exercise on an empty stomach?If you want to uncover the right foods for your body, head to joinzoe.com/podcast and get 10% off your personalised nutrition program.Mentioned in today's episode:Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese from The Journal of Clinical Endocrinology & Metabolism Body composition changes associated with fasted versus non-fasted aerobic exercise from Journal of the International Society of Sports Nutrition The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis from Sport Medicine Exercising Tactically for Taming Postmeal Glucose Surges from Hindawi Exercise-stimulated glucose uptake — regulation and implications for glycaemic control from Nature Reviews EndocrinologyFollow ZOE on Instagram. Episode transcripts are available here.Is there a nutrition topic you'd like us to explore? Email us at podcast@joinzoe.com, and we'll do our best to cover it.

In today's episode, Julia talks with Dr. Aimee, a renowned fertility specialist recognized as the "egg whisperer."  Together, Julia and Dr. Aimee delve into her complete “obsession to bring more love into this world” by helping more intended parents conceive.  They also discuss the many ways she is changing the patient experience by shifting the mindset around fertility treatment - from one of a battle to one of glitter, hope, and magic.    Dr. Aimee distinguishes her approach to in vitro fertilization (IVF) from that of her peers, emphasizing her focus on "OLS (Ovarian Life Support)" and her unwavering dedication to retrieving every viable egg from her patients. While she exudes enthusiasm for IVF, Dr. Aimee remains pragmatic, acknowledging that not every woman will achieve pregnancy, and she candidly reveals how she navigates such circumstances. Don't miss this captivating two-part series.   IN THIS EPISODE:   [02:48] Dr. Aimee shares her love of being a fertility doctor, knowing that was her calling from an early age [05:05] Why is she called ‘the egg whisperer' and getting through the hard stuff [10:15] Dr. Aimee's advice to someone who is discouraged. Who is her typical patient [13:24] How her process is different than other specialists and how she is committed to treating women in all 50 states [21:55] How she advises someone who loses a baby  [25:55] Dealing with the cost of IVF and Dr. Aimee's hope for the future [30:30] Dr. Aimee encourages patients to know their medical history and the procedures they have had to prevent mistakes  [33:28] Dr. Aimee defines family   KEY TAKEAWAYS:   Dr. Aimee provides online IVF classes available to anyone. They are similar to getting a full consultation. Learn about IVF. Remember your treatment history. Don't expect every doctor to remember the details about your medical treatments. Be your advocate.  After many treatments and discouragements trying to get pregnant, you might need to stop and take a break to see if going through more treatment is right for you. Be realistic.    RESOURCE LINKS:   Stork'd - Facebook   Stork'd - Instagram   Stork'd - YouTube    Dr. Aimee - Facebook   Dr. Aimee - Website   Egg Whisperer - Instagram   Egg Whisperer School - Website   BIO Dr. Aimee graduated from UCLA School of Medicine and completed her residency in Obstetrics & Gynecology at Harvard Medical School. She also completed a fellowship in Reproductive Endocrinology & Infertility and holds a Master's in Public Health Management and Policy from the University of Michigan.   She has presented her research at the national meetings of the American Society of Reproductive Medicine, The Endocrine Society and The American College of Obstetricians and Gynecologists. Her research has been published in several journals, including Fertility and Sterility, The Journal of Clinical Endocrinology and Metabolism, Obstetrics and Gynecology and Menopause. She is a fellow of the American College of Obstetrics and Gynecology and continues to contribute to research in the field of reproductive endocrinology and infertility. She has co-authored book chapters on ultrasonography and male infertility with national leaders in the field of reproductive endocrinology.   In her off-time, Dr. Aimee is a mom to four rambunctious kids aged ten and under. You can email her directly at email@draimee.org

In this episode the Endocrine Surgery team at BTK goes over two cases to review the American Association of Endocrine Surgeons Guidelines for Adrenalectomy.  Dr. Michael Yeh is a Professor of Surgery at UCLA and serves as Section Chief of the UCLA Endocrine Surgery program which he established.  Dr. Masha Livhits is an Assistant Professor of Surgery at UCLA and works in the Endocrine Surgery Department Dr. James Wu is an Assistant Professor of Surgery at UCLA and works in the Endocrine Surgery Department  Dr. Na Eun Kim is an Endocrine Surgery Fellow at UCLA in his first year of fellowship Dr. Rivfka Shenoy is a PGY-5 General Surgery Resident at UCLA who has completed two years of research  Dr. Max Schumm is a PGY-5 General Surgery Resident at UCLA who has completed two years of research. He is a future endocrine surgeon.  Important Papers  Yip L, Duh QY, Wachtel H, Jimenez C, Sturgeon C, Lee C, Velázquez-Fernández D, Berber E, Hammer GD, Bancos I, Lee JA, Marko J, Morris-Wiseman LF, Hughes MS, Livhits MJ, Han MA, Smith PW, Wilhelm S, Asa SL, Fahey TJ 3rd, McKenzie TJ, Strong VE, Perrier ND. American Association of Endocrine Surgeons Guidelines for Adrenalectomy: Executive Summary. JAMA Surg. 2022 Oct 1;157(10):870-877. doi: 10.1001/jamasurg.2022.3544. PMID: 35976622; PMCID: PMC9386598. Schumm M, Hu MY, Sant V, Kim J, Tseng CH, Sanz J, Raman S, Yu R, Livhits M. Automated extraction of incidental adrenal nodules from electronic health records. Surgery. 2023 Jan;173(1):52-58. doi: 10.1016/j.surg.2022.07.028. Epub 2022 Oct 4. PMID: 36207197. M. Conall Dennedy, Anand K. Annamalai, Olivia Prankerd-Smith, Natalie Freeman, Kuhan Vengopal, Johann Graggaber, Olympia Koulouri, Andrew S. Powlson, Ashley Shaw, David J. Halsall, Mark Gurnell, Low DHEAS: A Sensitive and Specific Test for the Detection of Subclinical Hypercortisolism in Adrenal Incidentalomas, The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 3, 1 March 2017, Pages 786–792, https://doi.org/10.1210/jc.2016-2718 Amar, L., Pacak, K., Steichen, O. et al. International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers. Nat Rev Endocrinol 17, 435–444 (2021). https://doi.org/10.1038/s41574-021-00492-3 **Fellowship application link: https://forms.gle/PiKM2MMQpE5jSAeW7 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other endocrine episodes here: https://behindtheknife.org/podcast-category/endocrine/