Podcasts about Frax

The Rollup TV presents: Mammoth May.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl

Broadcast from KSQD, Santa Cruz on 5-15-2025: Dr. Dawn provides a comprehensive overview of bone health, describing bones as the "silent architects" of our bodies that require ongoing care and attention throughout life. She outlines key risk factors including family history of fractures, eating disorders, hormonal changes, digestive surgeries, and medication use, while explaining how DEXA scans measure bone density through T-scores and Z-scores, recommending the FRAX risk calculator as a superior predictive tool. She shares practical strategies like weight-bearing exercise and proper vitamin supplementation (D, K2, calcium) alongside explaining the roles of osteoclasts and osteoblasts in bone turnover and how medications influence this balance. She addresses a caller's question about strontium citrate and isoflavone supplements for bone health after cancer treatment, clarifying that these differ from problematic boron and suggesting C-telopeptide or N-telopeptide testing to verify bone turnover rates beyond DEXA results. The program discusses a promising non-hormonal male contraceptive called ADAM, a dissolvable hydrogel implant shown in preliminary trials to block sperm for up to two years without serious side effects. Dr. Dawn addresses misconceptions about autism, describing it as a spectrum with diverse manifestations, explaining its neurological basis in atypical brain pruning patterns, and emphasizing it as a complex genetic vulnerability to environmental events. She evaluates a listener email about a supplement for urinary incontinence and metabolic health, warning listeners about marketing tactics and insufficient evidence behind many commercial products. Dr. Dawn examines "Fatty 15," a pentadecanoic acid supplement marketed for metabolic health, noting that while some rodent studies show promise for insulin sensitivity and liver health, human evidence remains limited compared to well-established benefits of omega-3 fatty acids. Dr. Dawn shares news about Orforglipron, a new oral GLP-1 medication in pill form for diabetes and weight management that appears as effective as injectable versions like Ozempic.. The show concludes with information about innovative plant-based transparent paperboard, a cellulose-based material that biodegrades within 300 days while offering a safer and more sustainable alternative to conventional plastics.

Welcome to The Rollup TV.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl

Welcome to The Rollup TV.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl

Ethereum has achieved groundbreaking technological success, but has it failed to properly define ETH the asset? In this episode, Frax founder Sam Kazemian joins us to discuss what he believes is Ethereum's biggest mistake: confusing the ETH asset with Ethereum the technology. Sam argues that post-EIP-1559 and Proof of Stake, ETH unintentionally shifted toward a discounted cash flow (DCF) valuation model, undermining its potential as a commodity-like store of value. We explore how the Ethereum community can reclaim a stronger narrative around ETH and why social consensus — not just tech — determines an asset's destiny. ------

Hola :)En el episodio de hoy os cuento por qué la osteoporosis es una enfermedad que, comienza a gestarse en la infancia y que pasa desapercibida hasta que da la cara con una fractura. Que, en españa la osteoporosis es la responsable de 33 fracturas por fragilidad cada hora y por qué todo el mundo deberia conocer la importancia de conservar la masa ósea para que la prevención sea cada vez un hecho.Asimismo os cuento qué farmacos y enfermedades se asocian con osteoporosis y por tanto hay que vigilar con especial detalle insistiendo mas en las medidas del estilo de vida como ejercicio fisico de fuerza e impacto, adecuada nutrición y cese de habitos toxicos.Cómo se diagnostica osteoporosis, pudiendo valorar incluso tu riesgo con la herramienta online gratuita y universal FRAX ( de cada pais) Qué medidas de suplementación pueden ayudarnosQué fármacos son los que actualmente están disponibles, sus pro y contras :)Ojala os guste y sobre todo aprendais :)Para mas información ya sabéis que me tenéis en mi instagram @isabelvina dónde te comparto contenido diario Mi TikTok @isabelvinabasEn mi canal de YouTube https://www.youtube.com/channel/UC-dfdxLBcvfztBvRAKZSXGQY los suplementos formulados por mi https://ivbwellness.com

Hello, Kaiju Lovers…and welcome, Listeners with Attitude! Nate takes advantage of his short time back on the Island to produce a Patreon-sponsored episode requested by first-time MIFV MAX member Andrew Wynja “The Ninja,” who picked the Power Rangers: Time Force VHS “Clash for Control.” So, naturally, Nate couldn't do this without his former Power Trip co-host Michael Hamilton. These episodes feature the first appearance of Wynja's favorite Zord, the amazing mecha-dinosaur Quantasaurus Rex (or Q-Rex), and Nate's Power Ranger “man crush,” Eric Myers, in an epic time travel adventure. But the reason Wynja chose this VHS edition of the episodes is because this was before they were censored in light of the September 11, 2001, terrorist attacks. Tune to hear about this and more! “Time for…Time Force!” Featuring Andrew Wynja as Frax. Jimmy's Notes on this episode COMING SOON!  For complete shownotes, inlcuding a bibliography of sources, visit this episode's post on the MIFV website: https://monsterislandfilmvault.com/index.php/2025/04/05/episode-101-power-rangers-time-force-clash-for-control-ft-andrew-wynja-and-michael-hamilton-patreon/.  Additional Music: “Galaxy Quest (Instrumental) [Main Titles]” by HeavenWraith Check out Nathan's spinoff podcasts, The Henshin Men and The Power Trip, and Henshin Power V3! We'd like to give a shout-out to our MIFV MAX patrons Danny DiManna (author/creator of the Godzilla Novelization Project); Damon Noyes, The Cel Cast, TofuFury, Eric Anderson of Nerd Chapel, Ted Williams, Wynja the Ninja, Christopher Riner, The Indiscrite One, Eli Harris, Jake Hambrick, Matt Walsh (but not that Matt Walsh), Jonathan Courtright, Leon Campbell, Michael Watson, and Sam Allred! Thanks for your support! You, too, can join MIFV MAX on Patreon to get this and other perks starting at only $3 a month! (https://www.patreon.com/monsterislandfilmvault) Buy official MIFV merch on TeePublic! (https://www.teepublic.com/user/the-monster-island-gift-shop). NEW MERCH NOW AVAILABLE! This episode is approved by the Monster Island Board of Directors. Timestamps: Introduction: 0:00-11:11 Main Discussion – Production History and More: 11:11-29:00 Main Discussion – Episode 12: “Worlds Apart”: 29:00-49:52 Main Discussion – Episode 13: “The Quantum Quest”: 49:52-1:13:08 Main Discussion – Episode 14: “Clash for Control, Part 1”: 1:13:08-1:43:12 Main Discussion – Episode 15: “Clash for Control, Part 2”: 1:43:12-2:02:58 Outro (housekeeping, etc.): 2:02:58-2:18:12 Credits: 2:18:12-end Podcast Social Media: MIFV Linktree: https://linktr.ee/monsterislandfilmvault Nate's Linktree: https://linktr.ee/nathan_marchand MIFV is a member of PodNation (https://podnation.tv/) MIFV is one of Feedspot's top 10 tokusatsu podcasts! (https://blog.feedspot.com/tokusatsu_podcasts/) MIFV is one of Feedspot's top 20 monster podcasts! (https://podcasts.feedspot.com/monster_podcasts/) www.MonsterIslandFilmVault.com #JimmyFromNASALives       #MonsterIslandFilmVault    #GodzillaRedux                       #Godzilla        #GodzillaVsMegalon #kaiju              © 2024, 2025 Moonlighting Ninjas Media

Punto y final a una nueva semana en AIRE FRESCO, algo más corta que la anterior, pero en la que nos hemos vuelto a divertir de lo lindo, sobre todo porque le hemos puesto la guinda al pastel con un jueves, 20 de marzo, en el que además de inaugurar la primavera, dejar atrás las fallas y haber felicitado con algo de retraso a todos los papás, hemos vuelto a tener una pléyade invitados que son de auténtico lujo.Empezando por un extraordinario trío de voces que nos han acompañado para presentar el libro en homenaje a la figura de Miguel Barceló, que se presenta este viernes 21 en la Fundación Mediterráneo de la C/ Alameda de Benidorm, formado por su nieto el senador Agustín Almodóbar, el escritor Martín Sanz y el patrocinador y presidente de la Fundación Frax, Matías Pérez Such, realizando una síntesis extraordinaria para repasar la vida y la obra de este personaje ilustre del Benidorm del siglo XX y la primera parte del XXI.Ángela Fuster, teniente de alcalde de Polop, que ya estuvo la pasada semana presentando actividades de agricultura y deporte en LEO RADIO, ha vuelto de nuevo para dar un gran avance de algunos de los muchos temas que contemplan el catálogo de posibilidades del programa cultural marzo-abril y presentar en exclusiva el nuevo folleto turístico de Polop de la Marina. Sin duda un gran trabajo al servicio de un pueblo que ha encontrado con esta edil una persona dedicada en cuerpo y alma a defender los intereses del oasis de la Costa Blanca.Padre e hija, Elena y Serge Gambi, también nos han visitado para presentarnos el premio conseguido por ella en el Circo de Lux de Luxemburgo y hablarnos de sus proyectos de futuro para con el mundo del circo, más de moda que nunca y renovado como no se ha visto en las últimas décadas. Hemos aprovechado para hacer un repaso por la historia de esta cultura tan arraigada en el psique de la conciencia europea y avanzar el curso que Elena Gambi ofrecerá en Polop el día 5 de abril, una Masterclass de Malabares.Aun quedaba más por disfrutar. La gran sorpresa la hemos conocido al entrar al micrófono nuestra siguiente invitada. Cristina Alexandra, compañera y colaboradora de LEO RADIO nos ha soltado la bomba, está embarazada. !Enhorabuena, compañera¡, crece la familia de la radio. Y en su sección “El Arte de Cuidarte”, hemos hablado hoy de los hábitos que todos conocemos pero no nos aplicamos para estar mucho mejor con nosotros mismos.Vicente Saval, gerente de Nos Importas y Abonabe, nos ha presentado hoy el resultado final del “Iberia Motor Fest”, que nace, en su tercera edición, ya después de todo un año de trabajo. Viernes, sábado y domingo, miles de motos y coches de época se darán cita en la playa de Villajoyosa para que disfrutes del mejor olor a gasolina y ruido de los motores, acompañado de la mejor música y ambiente que sólo viviéndolo podrás explicártelo.

Joining the Weekly Rollup this week is Haseeb Qureshi, dissecting Trump's controversial Crypto Strategic Reserve announcement featuring Bitcoin, Ethereum, Solana, Cardano, and Ripple—causing an initial market surge and a swift reversal. They unpack Sam Bankman-Fried's candid prison interview with Tucker Carlson, revealing a stark divide between human empathy and detached pragmatism. Plus, Trump's erratic tariff policies are rattling macro markets; is it strategic or simply chaotic? Finally, they delve into Ethereum's leadership shuffle, Base's new speed upgrade challenging Solana, and AI's profound reshaping of crypto startups and blockchain usability. Follow Haseeb: https://x.com/hosseeb ------

Joining us this week is Alex Thorn to break down why crypto markets are taking a hit. Major hacks, bearish macro signals, and fresh tariffs from the U.S. all played a role. But it's not all bad news: the SEC is backing off from lawsuits against Coinbase, OpenSea, and Uniswap, signaling a potential shift in regulatory pressure. Plus, Bybit suffered the biggest crypto hack ever, losing $1.5B—how did it happen, and who's behind it? Follow Alex: https://x.com/intangiblecoins ------

This week's Weekly Rollup covers Trump's clash with the Fed over interest rates and the surprising crypto moves from Trump Media. Gauntlet's Tarun Chitra joins us to unpack the latest developments—from OpenSea's upcoming airdrop to Arbitrum's permissionless fault proofs—while we debate whether airdrops are truly over. We also dig into Vitalik's “communist” joke and Dave Portnoy's memecoin mania. Tune in for all the drama and alpha happening in the second week of February! ------

The stablecoin landscape is evolving as DeFi and traditional finance continue to merge.Today we chat with Sam Kazemian from Frax to break down what's happening in the space. We'll dive into their new FRX USD launch and explore an interesting idea: using stablecoins to bridge the gap between crypto and U.S. treasuries.Sam also walks us through how Frax is rethinking stablecoin design to make yield more accessible, while partnering with big players like BlackRock and SuperState. Sam also shares insights on stablecoins' potential to reshape the broader financial system beyond just crypto.If you've been thinking about where stablecoins are headed, this is one to tune into.Join The Rollup Edge: https://members.therollup.coWebsite: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl

Frax launches the frxUSD stablecoin. Blockscout releases new features for interacting with smart contracts. And WalletConnect publishes its first governance proposal. Read more: https://ethdaily.io/643

In episode 593, Mike and James invite Samantha Moe back to talk about a newer agent for osteoporosis. So, if you want to know all the evidence for romosozumab, tune in and all will be revealed about the benefits and harms. Show notes 1) Tools for Practice Tony Romo-sozumab: Winning touchdown in osteoporosis or interception for the loss? 2) FRAX site for Canada

In this episode of Bankless, Luca Netz, CEO of Pudgy Penguins, explores how meme coins are evolving beyond speculation. We discuss Pengu's launch on Solana, Pudgy Penguins' expansion into retail and gaming, and how GIFs with 300M+ daily views are driving mass adoption. Luca also shares why meme coins can be real brands and what's next for Pudgy's growing ecosystem. ------

Ejaaz is back with David to unpack the whirlwind effects of President Trump's $70B memecoin launch, which slammed 400K fresh users onto Solana and shattered revenue records in under 30 hours. Meanwhile, a $500B federal boost to AI—backed by OpenAI and SoftBank—has everyone on edge about how crypto's AI agent economy might ride this newfound momentum. On the protocol front, Arc's Rake framework and AI16z's curated Eliza ecosystem are both stepping up, incubating projects like SoulGraph and Listen that promise a more user-friendly DeFAI future. Virtuals keeps shipping at breakneck speed too, testing new multi-chain waters, instituting a bold buyback, and hinting at metaverse collabs that could reshape gaming for good. From automated DeFi positions and trading dashboards to fully autonomous NPCs that commentate (and maybe soon play) your favorite games, the lines between AI and crypto are getting blurrier—and more exciting—by the day. Buckle up as the AI agent revolution continues to redefine what “on-chain” can really mean. Ready for the ride? ------ BANKLESS SPONSOR TOOLS:

Today's blockchain and cryptocurrency news  Bitcoin is up slightly at $101,483 Eth is up half a percent at $3,206 XRP, down half a percent at $3.04 Ledger co-founder kidnapped, held, freed. Caroline Pham has selected Harry Jung to lead the agency's crypto engagement. Jump Trading sues former employee Frax community considers WLFI position Nasdaq's official X account hacked. Learn more about your ad choices. Visit megaphone.fm/adchoices

Sam Kazemian, founder of Frax Finance, outlined the development and goals of FraxUSD, a decentralized stablecoin designed to integrate with both traditional finance and decentralized ecosystems. The upgraded FraxUSD offers redeemability through custodians like BlackRock and SuperState while providing competitive yields through diversified strategies. Kazemian described Frax's broader vision as building a digital economy anchored by its flagship stablecoin and Fraxstool, a high-performance Ethereum Layer 2. Chapters 00:00 - Introduction 00:48 - Founding Story and Differentiation of Frax 02:01 - Vision for Decentralized Stablecoins 02:41 - Features of FraxUSD 08:51 - Best of Both Worlds Design for FraxUSD 13:08 - Future of Stablecoins 23:05 - Yield Strategy of FraxUSD 34:16 - FraxUSD in Real World and On-Chain Usage 42:02 - Stablecoins as the Gateway to Crypto 47:12 - Roadmap and Future of Frax ✨ Check out our new website ✨ https://thedefiant.io/

Ejaaz is back with David to dissect the accelerating rise of AI agents at crypto's cutting edge. They uncover how Arc's multi-chain approach and Ai16z's Eliza framework are igniting a fresh wave of DeFAI innovation—everything from clever Twitter agents to more autonomous protocols. They dive into Virtuals' relentless shipping, which is driving record on-chain fees and fueling a bold $40M buyback, while exploring why upcoming gaming collaborations may unlock AI's next breakout moment. New players like Ava and Pippin also take center stage, proving both the promise and FUD-fueled volatility of this fast-growing sector. Whether it's DeFi revamps, multi-chain expansions, or full-blown AI-driven games, this episode outlines the major trends shaping crypto and AI's convergent future. Ready for the ride? Further DAO Drama Conext  https://x.com/TrustlessState/status/1878538551668736415 ------

David and Ejaaz are joined by Jeffy and Tint, creators of Zerebro—an autonomous AI agent that composes rap tracks, launches NFTs, and even minted its own token by hijacking Jeffy's computer. This on chain sensation transcends mere GPT wrappers, forging a bold new path for AI in crypto. How does an AI manage cross-chain finances, get deplatformed by Spotify, and still power a no-code framework for agent creation? We explore Zerebro's role in reshaping digital commerce and creativity, and what it means for the future of decentralized intelligence. ------

Do you think you've got what it takes to become a founder in crypto? On the show today we've got 8 of crypto's most famous and successful builders in crypto, each with about 15 minutes in time, giving you the wisdom they gained founding their own companies. We're joined by Jesse Pollack from Base, Jeremy Allaire from Circle, Anatoly from Solana, Stani from Aave, Kain from Synthetix, Mike & Jason from Blockworks, Kevin Owocki from Gitcoin and Lucas from Jito. Each one with their own perspectives, their own scars and hopefully by listening to this episode, you, the listener, can learn from their experiences to gain the confidence you need to venture into this world. ------

Tune in to this episode of the Security Token Show where this week Herwig Konings and Kyle Sonlin cover the industry leading headlines and market movements, including how we've crossed $50B in market cap and even some predictions! Join the RWA Foundation and Read the Whitepaper: RWAF.xyz  Read STM's Global Tokenized Real Estate Market Guide 2024: https://docsend.com/view/rrfjz7zxzqb9na2q   Read the RWA Securities Market Update: https://docsend.com/view/7k8mr83xsgyt57yh   Company of the Week - Herwig: Frax Company of the Week - Kyle: Nest  = Stay in touch via our Social Media = Kyle: https://www.linkedin.com/in/kylesonlin/   Herwig: https://www.linkedin.com/in/herwigkonings/  Nico: https://www.linkedin.com/in/nicopantelis/   Jason: https://www.linkedin.com/in/jasonbarraza/   Opinion articles, interviews, and more: https://medium.com/security-token-group   Find the video edition of this episode on our Youtube Channel: https://www.youtube.com/@stmtvofficial The Market Movements 1. Frax Allocations Announced: https://beincrypto.com/frax-stablecoin-blackrock-buidl-fund/  / https://x.com/superstatefunds/status/1874935000820310326   2. Nest and Dinari Tokenize Blackstone Senior Loan ETF Vault: https://www.news-journal.com/nest-partners-with-dinari-to-deliver-real-world-yield-through-first-tokenized-blackstone-etf-on/article_2e936434-cf32-5857-a329-d54f77b37a1e.html     3. Plume Network Launches $25M RWA Tokenization Fund: https://www.prnewswire.com/news-releases/plume-network-launches-25-million-rwafi-ecosystem-fund-to-accelerate-real-world-asset-tokenization-and-innovation-302341436.html   4. Ondo to Natively Issue USDY on Plume Network: https://www.prnewswire.com/news-releases/plume-network-taps-ondo-finance-to-broaden-rwafi-ecosystem-with-tokenized-us-treasuries-302340097.html   5. Plume Network and Maseer To Tokenize $200M in Carbon Allowances: https://enterprisetalk.com/quick-bytes/plume-network-partners-with-maseer-to-tokenize-usd-200m-in-carbon-allowances-on-chain   The Token Debrief 1. Mizuho Securities and Blue Sky Tokenize Renewable Energy Business: https://www.ledgerinsights.com/mizuho-securities-involved-in-security-token-for-renewable-energy/   2. Franklin Templeton to Expand BENJI and Looks at More ETFs: https://blockworks.co/news/franklin-templeton-etfs-tokenization-2025   3. T-Bank to Enter Tokenization; Bank of Russia's CBDC Receives Negative Feedback: https://coingeek.com/russia-cbdc-faces-opposition-t-bank-dabbles-in-tokenization/   4. Binance Wallet Now Supports Matrixdock's XAUm Gold Token: https://thetokenizer.io/2024/12/30/matrixdock-integrates-xaum-gold-token-with-binance-wallet-to-advance-financial-equality/   5. Singularity Finance and Crymbo Partner on FATF Travel Rule Compliance: https://zycrypto.com/singularity-finance-partners-with-crymbo-to-streamline-digital-asset-compliance-with-fatf-travel-rule/   ⏰ TABLE OF CONTENTS ⏰ 0:16 Introduction 1:53 Market Movements 18:53 RWA Foundation Weekly Update 21:25 Token Debrief 32:35 Companies of The Week: Nest and Frax

Frax governance approves BUIDL as collateral. Kartik introduces the Anon World social network. IDRISS announces its IDRISS token. And claims for ZKsync's ZK token close on January 3rd. Read more: https://ethdaily.io/617

On this special episode, we welcome back Sam Kazemian, co-founder of Frax, to dive into the Fraxtal Vision Roadmap. A plan set in 3 phases, introducing token upgrades, AIVM, and becoming the microstrategy of ETH with Frax's Crypto Strategic Reserve.Timeline:00:00 Introduction & Background03:05 State of Crypto Post-Elections08:10 Convos w/ Legislators + Staffers in DC11:48 Reflections on Fraxtal and the L2 Playbook15:36 Running a Protocol vs an L217:23 The Vision Roadmap: Sovereign Assets and AI Integrations18:37 Phase 1: Tokenomic upgrades, The Future of FRAX.36:43 Proof of Inference and AI Agents Onchain49:18 Retaking on Fraxtal Securing Different VMs53:30 Frax: The MicroStrategy of ETH1:01:55 The Crypto Strategic Reserve1:04:37 Key Takeaways of The Vision Roadmap1:06:31 Post-Game~~~~Subscribe to the Flywheel mailing list: https://flywheeldefi.com~~~~Follow FlywheelX: https://twitter.com/FlywheelDeFiTelegram: https://t.me/FlywheelDeFiYouTube: @flywheeldefiSpotify: https://open.spotify.com/show/34xXNO289naHrPB2h4uN4J?si=7aa710b683c04a66Apple Podcasts: https://podcasts.apple.com/ca/podcast/flywheel-defi/id1628697864~~~~ConnectDeFi Dave: https://twitter.com/defidave22Kiet: https://twitter.com/0xkapital_kSam: https://twitter.com/traders_insightLewy: https://x.com/lewquidity~~~~Not financial or tax advice. This channel is strictly educational and is not investment advice or a solicitation to buy or sell any assets or to make any financial decisions. This video is not tax advice. Talk to your accountant. Do your own research.

Gm! This week, we're joined by Dan Smith from Blockworks Research. We discuss what's happening on Solana as total economic value keeps reaching new highs. We deep dive into Solana's inflation, staking SOL, Solana's transition to a top three asset within crypto & comparing the 2021 cycle to today. Enjoy! – Follow Dan: https://x.com/smyyguy Follow Jack: https://x.com/whosknave Follow Mert: https://x.com/0xMert_ Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Ledger, the global leader in digital asset security, proudly sponsors the Lightspeed podcast. As Ledger celebrates 10 years of securing 20% of global crypto, it remains the top choice for securing your Solana assets. Buy a LEDGER™ device now and build confidently, knowing your SOL are safe. Buy now on Ledger.com. -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (03:14) Solana Economics (07:55) Staking SOL (15:08) Sei Protocol Ad (15:35) Ledger Ad (16:11) Solana's REV All Time High (24:33) Sandwiching Attacks (29:18) Solana's Fee Market (41:50) The 2021 Cycle vs Now -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! This week, we're joined by Eliezer Ndinga of 21 Shares to discuss the path forward for a Solana ETF. We deep dive into the election impact on regulation within crypto, DeFi's renaissance, the SEC vs crypto & why Eliezer is bullish on Solana. Enjoy – Follow Jack: https://x.com/whosknave Follow Eliezer: https://x.com/elindinga Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Ledger, the global leader in digital asset security, proudly sponsors the Lightspeed podcast. As Ledger celebrates 10 years of securing 20% of global crypto, it remains the top choice for securing your Solana assets. Buy a LEDGER™ device now and build confidently, knowing your SOL are safe. Buy now on Ledger.com. -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (01:32) The Election Impact (06:28) DeFi Renaissance (08:48) The SEC vs Crypto (13:44) Ethereum vs Solana Dominance (19:33) Sei Protocol Ad (20:00) Ledger Ad (20:36) The Solana ETF (34:02) Solana ETF Demand (37:58) The 2025 Crypto ETF Cycle (42:19) Bullish On Solana -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! This week, Andrej Radonjic joins the show to discuss the recent Grass airdrop, how crypto can help fix the internet, the intersection of AI & crypto & much more. Enjoy! – Follow Andrej: https://x.com/0xdrej Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) - Introduction (02:08) - Airdrop Takeaways (11:35) - Web Scraping (18:38) - Sei Ad (19:04) - DePiN & Grass Data Capacity (27:54) - Token Demand & Utility (30:36) - Training AI Models (33:56) - Can Crypto Fix The Internet? (37:14) - Monetizing AI (40:04) - Building On Solana (42:55) - Rollups (45:30) - What's Next For Grass? -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! This week, we're back with another roundup. We discuss Solana's on chain boom, why economic value reached a new all time high, Stripe's recent acquisition of Bridge & much more. Enjoy! – Follow Mert: https://x.com/0xMert_ Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (01:29) Solana's On Chain Boom (10:17) Solana's Breaking Point (14:21) Firedancer (18:47) Sei Ad (19:13) Solana's Economic Value (22:37) Memecoins & Fee Markets (31:35) Meme's (35:31) Stripe Acquires Bridge (40:35) Crypto M&A, IPOs & Regulation (45:07) Crypto Mobile Apps (56:11) SocialFi -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! This week, we're joined by Daniel Lev from Coinflow! We discussed Stripe's acquisition of Bridge, challenges faced by crypto payments businesses, and TradFi's adoption of stablecoins. Additionally, we unpacked the impact of US regulations on the stablecoin sector, and the fees associated with on and off-ramps in crypto. Finally, we covered interesting use cases Coinflow is enabling today. Enjoy! – Follow Coinflow: https://x.com/CoinflowLabs Follow Daniel: https://x.com/SirDigitalDan Follow Mert: https://x.com/0xMert_ Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (01:45) Stripe Acquires Bridge (07:03) Challenges Faced By Payments Businesses (10:46) The Problems With ACH (14:07) TradFi Adoption of Stablecoins (26:58) Sei Ad (27:25) How Cypherpunk Are Stablecoins? (30:49) Struggling With US Regulations (41:06) Fees Associated With Crypto Ramp Providers (45:53) Daniel's Journey Before Coinflow (50:28) Gaining Solana Labs as a Client (52:04) Mobile Integrations (55:10) What Is Coinflow Enabling Today? -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! this week, we're live at Permissionless with a discussion on crypto's creator economy. We deep dive into capturing attention in crypto, building DRiP, why build on Solana, NFTs, meme coins & more. Enjoy! -- Follow Vibhu: https://x.com/vibhu Follow Steve: https://x.com/solanasteve_ Follow Jake: https://x.com/SolJakey Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- (00:00) Introduction (01:22) Crypto's Creator Economy (07:14) Capturing Attention In Crypto (13:27) Content On DRiP (17:24) Why Build On Solana? (17:50) Sei Ad (25:57) Investments vs Commerce In Crypto (29:28) Building A Media Company In Crypto (31:22) NFTs (42:21) Will DRiP Ever Launch A Token? (45:38) Meme Coins -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

OsteoporosisListen along to Dr Sagen Zac-Varghese, Dr Amy Purohit and Dr Elinor Roderick as they discuss osteoporosis. They discuss identifying people with osteoporosis, investigating for causes of falls and secondary causes of osteoporosis, use of FRAX, understanding bone mineral density, and, management to reduce fracture risk, including diet, exercise and medications. Sagen Zac-Varghese is a consultant in diabetes, endocrinology and general internal medicine and lead for undergraduate students at the East and North Herts NHS Trust. She is the RCP education representative for the RCP Advisory Group on Nutrition Weight and Health.Elinor Roderick is an academic foundation doctor at the East and North Herts Trust. Amy Purohit is an academic foundation doctor at the East and North Herts Trust.LinksRoyal Osteoporosis Society https://theros.org.uk/  National Osteoporosis Guideline Group https://www.nogg.org.uk/ FRAXhttps://frax.shef.ac.uk/FRAX/music: bensound.com

Gm! this week, we begin by discussing Snowden's recent comments that Solana is centralized. We then deep dive into Mert's biggest takeaways from recent conferences, the impact of Firedancer, reasons to be bullish DePin & more. Enjoy! -- Follow Mert: https://x.com/0xMert_ Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- (00:00) Introduction (03:28) Is Solana Centralized? (18:02) Defining Success In Crypto (23:49) Sei Ad (24:15) Firedancer (32:50) Solana TPS & Block Demand (39:37) The Firedancer Impact (44:49) Crypto's KOLs (53:09) Crypto Conferences (56:19) Bullish DePin -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! This week Arnold Lee joins the show to discuss how Sphere is accelerating global payments for fintech companies by leveraging Spherenet built on the SVM. We deep dive into what is Spherenet, the problem with global payments, permissioned vs permissionless systems & more. Enjoy! -- Follow Arnold: https://x.com/0xdirichlet Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain. With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- (00:00) Introduction (02:58) What Is Spherenet? (10:26) The Spherenet Roadmap (14:55) Sei Protocol Ad (15:22) Permissioned vs Permissionless Chains (25:18) The Future Of Crypto (33:03) Crypto Payments (48:14) Working With Iggy Azalea -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! In this episode, Sean Carey, Partner at Borderless Capital, joined us to discuss all things DePIN! We dove into DePIN selling points, the sustainability of DePIN projects, and what infrastructure makes the most sense for DePIN. Additionally, we spoke about why crypto and DePIN work so well together. Finally, we closed the episode by discussing Solana's impact on the future of DePIN networks. Enjoy! -- Follow Borderless Capital: https://x.com/borderless_cap Follow Sean: https://x.com/densone Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain.  With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (04:53) Borderless Capital's DePIN Fund (11:59) DePIN Selling Points to LPs (28:09) Sei Ad (28:36) How Many DePIN Projects Are Sustainable? (35:02) What Infrastructure Makes the Most Sense For DePIN? (43:21) DePIN Needs Crypto (58:33) Solana's Impact on DePIN (1:03:01) Optimizing L1s For DePIN -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! In this episode, we're joined by Andrea Fortunio, Co-founder of MagicBlock! We discussed the current state of the Solana gaming industry, AAA vs Mobile gaming, and the benefits of Ephemeral Rollups. Additionally, we dove into the security implications of utilizing optimistic rollups in onchain gaming. We ended the episode with coverage of MagicBlock's current timelines, and their experience in the A16z accelerator. Enjoy! Resources MagicBlock Engine footage: https://x.com/magicblock/status/1802717656102978040 – Follow MagicBlock: https://x.com/magicblock Follow Andrea: https://x.com/supermarioblock Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain.  With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (05:07) Why Run Games Fully Onchain? (11:42) The Solana Gaming Industry (15:47) AAA Games vs Mobile Gaming (18:05) Sei Ad (18:31) The Benefits of Ephemeral Rollups (36:41) Security Implications of Optimistic Rollups for Onchain Gaming (40:10) Why Not Build A L2? (46:16) MagicBlock Timelines (50:55) A16z Accelerator & Crypto Gaming Sentiment -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! In this episode, Jack and Ian Unsworth from Kairos Research discuss Solana Mobile's latest device, Seeker, and its potential impact on Solana's growth. Additionally, they dive into the value proposition for Non-Bitcoin ETFs, and Trump's upcoming DeFi project. They close out by asking - will Solana restaking be successful? Enjoy! Resources Helius Funding Announcement: https://x.com/0xMert_/status/1836578165977915858 Drift Funding Announcement: https://x.com/DriftProtocol/status/1836752136614658325 The Next Chapter of Solana Mobile: https://x.com/solanamobile/status/1836614409613119632 Cypherpunk Holdings Rebrands: https://blockworks.co/news/lightspeed-newsletter-sol-strategies-rebrand -- Follow Ian: https://x.com/Ian_Unsworth Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain.  With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (02:07) Drift & Helius Announce Funding Rounds (03:37) The Solana Seeker (20:16) Seeker's Impact On Crypto Gaming (28:12) Sei Protocol Ad (28:38) Cypherpunk Holdings Rebrands to Sol Strategies (35:16) The Value Proposition For Non-Bitcoin ETFs (41:27) Trump Buys Burgers With Bitcoin (44:01) Trump's DeFi Project (47:49) Will Solana Restaking Be Successful? -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! In this episode, MacBrennan, Co-founder of MarginFi, joined us to discuss the state of Solana DeFi, crypto founder exhaustion, and crypto's image problem. We also asked ourselves, where are the new users? Finally, told us how MarginFi has navigated 2024, and what he is optimistic about in crypto today. Enjoy! Resources MacBrennan's Take on Founder Exhaustion: https://x.com/macbrennan_cc/status/1824203471656194259 -- Follow MacBrennan: https://x.com/macbrennan_cc Follow Mert: https://x.com/0xMert_ Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed Utilize the Solana Dashboard by Blockworks Research: http://solana.blockworksresearch.com/ -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain.  With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (02:45) The State of Solana DeFi (07:28) Are Crypto Founders Exhausted? (16:46) Sei Ad (17:13) Where Are the New Users? (28:39) Crypto's Image Problem (38:09) MarginFi Today (48:45) Optimism in Crypto -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Gm! In this episode, Jack and Mert discuss the state of SocialFi, the lack of bold bets in crypto, and what it means for crypto to succeed. They also dove into how Proof of Stake systems should work, and how sandwich attacks can be reduced onchain. Finally, they covered new DePIN projects coming to market. Enjoy! -- Follow Mert: https://x.com/0xMert_ Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed -- DragonSwap is the DeFi Hub on Sei's Layer 1, allowing users to swap, provide liquidity, and farm! Built on Sei's sub-second execution environment, DragonSwap is transforming the DEX landscape by building an “onchain CEX” that leverages chain-abstracted AVSs, enabling users to buy any asset on any chain.  With tons of incentives already available, September will bring even more to Sei users with partners like Stargate and Frax! Start farming on Sei today by visiting https://dragonswap.app/ -- Subscribe on YouTube: https://bit.ly/43o3Syk Subscribe on Apple: https://apple.co/3OhiXgV Subscribe on Spotify: https://spoti.fi/3OkF7PD Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- (00:00) Introduction (04:08) Is SocialFi Dead? (17:20) The Lack of Bold Bets in Crypto (26:44) What Does It Mean For Crypto to Succeed? (32:27) Sei Ad (32:53) How Should A Proof of Stake System Work? (47:41) Reducing Sandwich Attacks (53:31) New DePIN Projects Coming to Market -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Bone density will decline with each decade in life. But it isn't a death sentence. Today we interviewed Dr. Susan Baumgaertel, MD FACP and we discuss menopause and the changes that happen in regards to bone density. You don't want to miss this!Here's the link to the FRAX score: https://frax.shef.ac.uk/FRAX/tool.aspx?country=9You can find Susan here: mymdadvocate.comDid you know that our YouTube channel has a growing number of videos including this podcast? Give us a follow here- https://youtube.com/@fixyoursciatica?si=1svrz6M7RsnFaswNAre you looking for a more affordable way to manage your pain? Check out the patient advocate program here: ptpatientadvocate.comHere's the self cheat sheet for symptom management: https://ifixyoursciatica.gymleadmachine.co/self-treatment-cheat-sheet-8707Book a free strategy call: https://msgsndr.com/widget/appointment/ifixyoursciatica/strategy-callSupport this podcast at — https://redcircle.com/fix-your-sciatica-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

In this episode of Flywheel, host DeFi Dave welcomes back Alex Golubitsky for a third time. They dive into recent regulatory shifts in the U.S., highlighting the bipartisan support for the Fit 21 Act, challenges with the SEC's SAB 121, and the potential impact of the Bitcoin ETF approval. They also discuss the innovative solutions presented by MetaLex, a new project co-founded by Alex, aimed at helping DAOs achieve legal recognition and operational efficiency.00:00 Introduction and Welcome01:15 Call to Action: Subscribe and Follow01:42 Regulatory Shift in the U.S.03:37 SAB 121 Explained05:14 Political Dynamics and Crypto15:50 The Fit 21 Act21:01 DeFi and Digital Commodities30:05 Challenges and Future of Crypto Regulation35:47 Crypto and Politics: A Bipartisan Issue37:18 The Future of Crypto Regulation41:16 The Role of the SEC and Gary Gensler45:45 The ETF Approval Process51:11 Introducing Metal X: Decentralizing Protocols52:17 The Legal Personhood of DAOs58:39 The Future of Metal X and Legal Tech01:03:02 Closing Remarks and Social Media Plugs~~~~Subscribe to the Flywheel mailing list: https://flywheeldefi.com~~~~Have ETH but don't know what to do with it? Swap it to FrxETH for the highest staking yields in crypto.https://app.frax.finance/frxeth/mint~~~~Calling all threadoors, researchers, and dashboard creators

In this episode of Flywheel, hosts DeFi Dave and Kiet are joined by 0xMaki and Glovin from Heroglyphs. Learn how Solo Stakers of ETH can mint memecoins and NFTs using Heroglyphs. The guests dive into the technical nuances of encoding graffiti on the Ethereum blockchain, the coordination game, liquidity pools, and harbinger tax systems. The episode also addresses the looming centralization threats within DeFi and highlights strategies for fostering decentralization through economic incentives and liquid staking.00:00 Welcome to Flywheel: Your Crypto and DeFi Hub02:05 Introducing 0xMaki and Glovin07:04 Exploring the Technical Aspects of Heroglyphs13:37 The Vision and Mechanics Behind Heroglyphs20:17 Heroglyphs: A New Era of Token Distribution and Validator Incentives36:27 The Coordination Game: Uniting Communities with Heroglyphs45:15 Reviving the Crypto Spirit: Fair Launches and Community Empowerment46:04 The Rise of Food Tokens and NFTs in Crypto Culture46:24 Validator Goals and the Push for Decentralization47:40 The Big Picture: Incentivizing Participation in Crypto Networks49:05 Exploring the Degeneracy: Liquidity Pools and Tokenomics54:23 The Vision of Heroglyphs: Beyond Meme Coins01:12:02 The Future of Heroglyphs: Roadmap and Launch Details01:20:46 Post-Game: Understanding Heroglyphs' Potential~~~~Subscribe to the Flywheel mailing list: https://flywheeldefi.com~~~~Have ETH but don't know what to do with it? Swap it to FrxETH for the highest staking yields in crypto.https://app.frax.finance/frxeth/mint~~~~Calling all threadoors, researchers, and dashboard creators

In this episode of Flywheel, hosts DeFi Dave and Kapital K introduce YieldNest, a cutting-edge platform revolutionizing the way users engage with liquid re-staking protocols (LRTs) and Automated Validator Selections (AVSs). Joined by YieldNest founders Deo (Amadeo Brands) and Dan, the conversation dives deep into the mechanics of re-staking, the assessment of risks associated with AVSs and LRTs, and the future of decentralized finance. Dio and Dan share their extensive backgrounds, from working in hedge funds and DAOs to their involvement in significant DeFi projects and protocols, emphasizing their commitment to decentralization and the innovative approach of YieldNest. The discussion also covers the complex landscape of DeFi, including the challenges of education within the space, the potential of meme coins merging with substantive technology, and the importance of building a self-sovereign digital nation state through DeFi.00:00 Welcome to Flywheel: Your Crypto and DeFi Hub00:16 Introducing YieldNest: Innovating in DeFi02:15 Deo's Journey: From Crypto Newbie to DeFi Innovator04:40 The Philosophy of DeFi and Building a Digital Nation State05:44 Challenges and Opportunities in DeFi's Growth07:09 Meme Coins: The Convergence of Memes and Technology08:47 Dan's Path: Engineering to DeFi Development19:58 YieldNest's Approach to Managing DeFi Risks25:48 Exploring the Nuances of Restaking Protocols26:05 The Technical and Economic Implications of Restaking27:40 Debating the Future of Blockchain Technologies28:07 The Competitive Landscape of Restaking Protocols32:49 Yieldnest's Approach to Restaking and Validator Management35:52 The Lifecycle of an LRT: From Deposit to Withdrawal44:21 Innovations and Challenges in Restaking Architecture52:41 Closing Remarks and How to Connect with Yieldnest~~~~Subscribe to the Flywheel mailing list: https://flywheeldefi.com~~~~Have ETH but don't know what to do with it? Swap it to FrxETH for the highest staking yields in crypto.https://app.frax.finance/frxeth/mint~~~~Calling all threadoors, researchers, and dashboard creators

Doctors Lisa and Sara talk to Dr Saadat Ahmed, ST5 in Geriatrics for a deep dive into Osteoporosis. We cover what it is, why it matters, what the risks factors are, who and how to assess for it, and what to do with results from FRAX and DXA scans. After a discussion on lifestyle options to help improve bone health, we ask advice on counselling patients around the pros and cons of taking Bisphosphonates including his advice on talking about the rarer side effects. We talk through a case and ask advice on how to reassess bone health after these initial conversations, and medications might have been started, including when to consider drug holidays.   Lots of excellent CPD here we feel. Enjoy and please share with any interested clinicians/trainees as you see fit.   Useful resources:  Osteoporosis - Prevention of Fragility Fractures NICE CKS Guidelines (updated Apr 2023): https://cks.nice.org.uk/topics/osteoporosis-prevention-of-fragility-fractures/ FRAX Calculator UK (Link from National Osteoporosis Guideline Group UK: https://frax.shef.ac.uk/FRAX/tool.aspx?country=1 WHO Falls Management: https://www.who.int/news-room/fact-sheets/detail/falls National Osteoporosis Guideline Group UK: https://www.nogg.org.uk/full-guideline/section-4-intervention-thresholds-and-strategy https://www.nogg.org.uk/full-guideline/section-7-strategies-management-osteoporosis-and-fracture-risk SIGN Scottish Osteoporosis Guidelines (discussion of evidence for links between PPIs and Osteoporosis on page 27): https://www.sign.ac.uk/media/1812/sign-142-osteoporosis-v3.pdf Osteonecrosis of the Jaw relative risk discussed on page 37 of National Osteoporosis Guideline Group UK: https://www.nogg.org.uk/sites/nogg/download/NOGG-Guideline-2021-g.pdf Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus, Journal of Bone and Mineral Research. Khan A et al 2015: https://pubmed.ncbi.nlm.nih.gov/25414052/ Flow Chart for Oral Bisphosphonates long term treatment and monitoring NOGG Guidelines: Page 35: https://www.nogg.org.uk/sites/nogg/download/NOGG-Guideline-2021-g.pdf Rubin KH, Rothmann MJ, Holmberg T, et al. Effectiveness of a two-step population-based osteoporosis screening program using FRAX: the randomized Risk-stratified Osteoporosis Strategy Evaluation (ROSE) study. Osteoporosis Int 2018; 29(3): 567-78. https://pubmed.ncbi.nlm.nih.gov/29218381/ Merlijn T, Swart KM, van Schoor NM, et al. The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial. J Bone Miner Res 2019; 34(11): 1993-2000. https://pubmed.ncbi.nlm.nih.gov/31220365/ Merlijn T, Swart KMA, van der Horst HE, Netelenbos JC, Elders PJM. Fracture prevention by screening for high fracture risk: a systematic review and meta-analysis. Osteoporosis Int 2020; 31(2): 251-7. https://pubmed.ncbi.nlm.nih.gov/31838551/ _____ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our quick anonymous survey here: https://pckb.org/feedback Email us at: primarycarepodcasts@gmail.com _____ This podcast has been made with the support of GP Excellence and Greater Manchester Integrated Care Board. Given that it is recorded with Greater Manchester clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions.  The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.

The modular thesis is growing week by week. We are seeing the rise of new L2s and appchains happening at a rapidly accelerating pace now. Our second podcast as a team featuring Sam Kazemian from Frax Finance is here. Frax started its journey as a decentralized stablecoin and has expanded significantly to include a broader range of DeFi tools and assets, making their modular L2 more appealing from our POV. The backbone of Frax's operations is its modular L2, Fraxtal, which brings together protocols, liquidity, and monetary policies within one chain. Fraxtal enhances efficiency and transparency, setting a foundation for Frax to function akin to a decentralized central bank. Within this framework, Fraxtal uses an incentivization system known as Fraxtal points, which rewards popular contracts based on their usage and gas consumption. This creates a reputation-based system that promotes sustainable development within the Frax ecosystem. Additionally, we discussed how Sam plans to encourage the development of L3s atop of Fraxtal. This means dApps can launch their own chains while benefiting from the underlying Frax protocol and liquidity. This is part of Frax's fractal scaling vision, where L2 and L3s can generate revenue and contribute back to the overall ecosystem. Explore how Fraxtal, powered by Frax, is morphing into its broader vision of becoming a decentralized central bank in todays episode! Hope you enjoy. The Rollup Frax Finance Website: https://frax.finance/ Frax Finance Socials: https://twitter.com/fraxfinance

In this episode, Leif and Daphne dive into the science behind antinutrients - Lectins, Phytates, and Oxalates. Are antinutrients as scary as some people would lead you to believe, or is there a safe way to consume them?Register for Menopause Mastery: https://www.vegansuperheroacademy.com/menopause-masteryCONNECT WITH THE VEGAN GYM:WebsiteInstagramFacebookYouTubeNEW TO THE VEGAN GYM?We're on a mission to help 1,000,000 vegans get into the best shape of their lives because we believe that the more healthy, fit vegans there are in the world, the faster veganism will spread. Let's work together to inspire change, spread compassion, and challenge the status quo.EPISODE REFERENCESBinding and the effect of the red kidney bean lectin, phytohaemagglutinin, in the gastrointestinal tract of suckling ratsRed kidney bean poisoning in the UK: an analysis of 50 suspected incidents between 1976 and 1989Plant lectins in cancer therapeuticsAssociations between plant-based dietary patterns and risks of type 2 diabetes, cardiovascular disease, cancer, and mortalityPhytic Acid: From Antinutritional to Multiple Protection Factor of Organic SystemsDietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study IIUrinary phytate concentration and risk of fracture determined by the FRAX index in a group of postmenopausal womenPhytate Decreases Formation of Advanced Glycation End-Products in Patients with Type II Diabetes: Randomized Crossover TrialIron absorption in man: ascorbic acid and dose-dependent inhibition by phytateCalcium oxalate in plants: formation and functionOxalate intake and the risk for nephrolithiasisA Study of Diet and Lifestyle and the Risk of Urolithiasis in 1,519 Patients in Southern ChinaRisk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan DietsDietary intake of fiber, fruit and vegetables decreases the risk of incident kidney stones in womenDietary oxalate and kidney stone formationSupport the show

Dr. Dustin Jones // #GeriOnICE // www.ptonice.com  In today's episode of the PT on ICE Daily Show, join Modern Management of the Older Adult division leader Dustin Jones discusses helping patients better understand their osteoporosis diagnosis, including learning to read a DEXA scan. Dustin also shares tips on discussing prognosis with patients as well as using the data supporting their osteoporosis diagnosis to inform your treatment choices & plan of care development. Take a listen to learn how to better serve this population of patients & athletes, or check out the full show notes on our blog at www.ptonice.com/blog. If you're looking to learn more about live courses designed to better serve older adults in physical therapy or our online physical therapy courses, check our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab. EPISODE TRANSCRIPTION INTRODUCTIONHey everybody, Alan here, Chief Operating Officer at ICE. Thanks for listening to the PT on ICE Daily Show. Before we jump into today's episode, let's give a big shout out to our show sponsor, Jane, an online clinic management software and EMR. The Jane team understands that getting started with new software can be overwhelming, but they want you to know that you're not alone. To ensure the onboarding process goes smoothly, Jane offers free data imports, personalized calls to set up your account, and unlimited phone, email, and chat support. With a transparent monthly subscription, you'll never be locked into a contract with Jane. If you're interested in learning more about Jane, or you want to book a personalized demo, head on over to jane.app.switch. And if you do decide to make the switch, don't forget to use our code ICEPT1MO at sign up to receive a one month free grace period on your new Jane account. DUSTIN JONESWhat's up team? Dustin Jones here. You are listening to the PT on Ice daily show brought to you by the Institute of Clinical Excellence. Today we're talking about osteoporosis diagnosis, prognosis, and treatment. This is a big topic that so many of the folks, older adults that we work with, they will receive this diagnosis or have this discussed with them. And a lot of times it's not given a lot of context or they don't have full understanding of what this really means for them and what they can do about it. Most importantly, what they can do about it. All right, so let's get into this. OSTEOPOROSIS: DIAGNOSIS We'll start with the diagnosis piece, just really defining what is osteoporosis and then spend a little bit more time on the prognosis side of things and the treatment because I feel like that's where we have a lot of opportunity to really serve our folks well. So osteoporosis, we're going to review, go all the way back to your formal training when you learn some of these numbers. that we may have forgotten, all right? So when someone is, when that conversation of bone mineral density starts to come into play, usually it's for postmenopausal women or males over 50 years old, start to look at bone mineral density. And the way that we can measure, objectively measure bone mineral density is through a DEXA scan. You'll see that D-X-A or D-E-X-A, that's Dual Energy X-Ray Absorbed Geometry or DEXA. This is the reason why everyone calls it that. So you're basically looking at bone mineral density. And if for individuals that are over that kind of 65 year range, you're going to get a score. That score is going to be a T score. And so we're taking the measurement of the minerals in the bone in a certain area and comparing that to same sex and race norms for a younger population. So we're comparing it to a younger cohort, and that's where you'll get those T-scores. And so based on those T-scores, you will get maybe something from 0 to negative 1, and that is considered to be normal and healthy. Then that negative 1 to negative 2.5 is that osteopenic range or osteopenia which means the bones are a little bit weaker but not full-blown osteoporosis just yet and then below negative 2.5 and below they will receive that osteoporosis diagnosis. Typically, along with the DEXA scan, a physician is doing a FRAX screen. This measures the 10-year risk of having a fracture. There's some different lifestyle questions and it'll basically spit out a percentage of likelihood that that individual is going to have a fracture within the next 10 years. And so those two pieces of information really formulate the, or someone giving a diagnosis, but then also the treatment that follows. And then based on those T-score readings, as well as the FRAC score, the pathways are typically, there's gonna be some pharmacology involved, right? Whether we're preventing bone resorption or really encouraging more bone formation and remodeling. And then they're typically going to give some blanket generic recommendation of exercise of weight bearing exercise. All right. Now, the tough part about this diagnosis, it can come from a whole host of different providers. So you can see primary care physicians, you know, kind of leading the charge of, you know, looking into bone mineral density. Internists can as well. Orthopedic physicians can as well. And so there will be different doctors that will be kind of looking into bone mineral density. And then they will often refer out to someone like an endocrinologist, for example, for further treatment and so there's a lot of people kind of involved talking about this and what at least I have seen is that this has been a topic that has been brought up and a lot of fear has been revolving around this topic but not a ton of guidance of what it really means day to day to really influence bone mineral density beyond taking that pill and you know quote-unquote weight-bearing activities. I've just worked with so many people that did not understand that diagnosis and what it actually meant. So just understand that. I'm not saying that always happens, but in a lot of the folks that I work with, that is typically the case. OSTEOPOROSIS: DIAGNOSIS So they're given this diagnosis and now let's talk about the prognosis. In particular, what I want to speak to is the opportunity to really dive in to the DEXA scan that our patients receive. And I'm not saying it is our place to kind of give a medical prognosis per se. Well, I guess when I'm saying prognosis is what can they expect going forward and to give them context of that diagnosis. So I'm mainly working the context of fitness now at Stronger Life in Lexington, Kentucky, and it's a gym for folks only over 55. And we're about four years old now, and so over the past four years, we've had a lot of members that have had at least a couple DEXA scans at this point. And so I'll put a field out for folks to send me some of their DEXA scans, and this is something that, these are conversations I'll typically have with folks anyway, once they get their DEXA scan. This is something I want you all to do. I want you to ask some of your folks that have osteoporosis on their, you know, their chart, their diagnosis list. Say, Hey, can I see your DEXA scan? Or, you know, if you're in a medical system, look up their DEXA scan, because it's really interesting. And you start to look at a lot of these reports and you'll have some of them that are more kind of narrative based, um, that, you know, are basically just several paragraphs kind of outlining, um, you know, what to expect, what they found, something more along the lines of, a bunch of words if you're not watching I'm just holding up some of these DEXA scans but more narrative but then a lot of them will actually have graphs of T-scores when they had that DEXA scan and where. So the most common areas are going to be the lumbar spine, the neck of both femurs, bilateral femurs, and then they'll kind of zoom out a little bit and look at the total hip as well. And so get those DEXA scans and look at some of those numbers. And when you start to look, what you're often going to find is variation amongst the different sites. So you can have individuals that may have that negative below negative 2.5, negative 2.5 or below, let's say at the neck of the left femur, for example. And then the neck of the right femur may be negative 1.7, osteopenic. The lumbar spine may be negative 1.5, for example, osteopenic. And so technically that person has osteoporosis on the left, on the left side, right? The right and the lumbar spine does not have osteoporosis, osteopenic, still a concern, right? But not as bad as that left side. That message is often missed by many of our patients. Now, I believe they're getting that message, you know, when they are getting these reports and having conversations with some of the physicians, but they're probably getting all kinds of recommendations. They're getting that diagnosed and all kinds of things that, you know, we only may only hear half of what is actually being said. But a lot of folks I work with, they will receive that diagnosis of osteoporosis that in reality is only in their lumbar spine, for example. and they will take that and own it as if every single bone in their body is brittle and about to combust under any type of pressure or load. They embrace that diagnosis as it's this global systemic osteoporosis. Every single bone I have is tremendously weak without acknowledging that there's some variability in different areas of the body. That piece of information for folks can be really eye-opening and very empowering. Oh my gosh, are you saying that I only really have this in this particular area of my body and not everywhere else? That's a sense of relief for a lot of folks. A lot of folks will take this diagnosis and view it as almost like a death sentence. everything. I am so weak. I'm so fragile. I need to be very careful. I'm going to break something, any bone I need to be very, very concerned about. Right. And that's not necessarily what's happening. It's usually in kind of one, maybe two areas that are a concern, particularly folks that are initially receiving these DEXA scans. And the cool thing about where I'm at now, working with folks for over four years, this individual, she's had a DEXA scan every two years. She was on a negative slope, negative three in 2017, negative 3.1 in 2019, negative 3.4 in 2022, and her most recent scan a couple months ago was negative 2.8. This is at her lumbar spine. and when you are able to give context to the diagnosis but then also be able to see over time you'll be able to spot trends and then hopefully be able to potentially reverse trends or slow down trends and we're seeing this at Stronger Life and I know many of y'all don't have the luxury of working with folks consistently you know three times a week over the course of several years but man if we can apply some of the interventions I'm going to talk about here in a second over the course of years you can have a significant influence in a lot of these DEXA scan readings and we're definitely seeing that and you can too. But I think that conversation, the prognosis, them understanding the diagnosis, where in particular that may be, that they understand every single bone in my body is not going to combust under pressure. This particular area may be more concerned, but I'm doing okay in these other areas. It's really good for them to hear that and that can be a more empowering message. OSTEOPOROSIS: TREATMENT Now the most important thing I think is that we take the information from this DEXA scan and then we use it in our plans of care. And so if I have someone that has maybe normal osteopenic in terms of the DEXA scan in their bilateral femurs, neck of their femurs, but then they're kind of borderline osteoporosis in their lumbar spine, for example, as a physical therapist, That gives me something that I can focus on, that I can give targeted interventions to give specific forces and stressors to that area in a very progressive manner, keep in mind, to stimulate a change in that bone mineral density or increase the odds that we can see change in their bone mineral density. So we take that information, use it for our plan of care. Some folks, you may be focused, all right, this left hip, let's load up this left hip a little bit more, do some unilateral stuff, staggered stance type things, not neglecting the other side per se, but if there's a big difference, we may want to give preference to one side or the other. If it's a spine, lots of loaded carries, deadlifts, those types of things where we're getting that axial compression, getting those forces through the spine. We can give target interventions. that's gonna encourage those bones to remodel, to get stronger, or potentially slow down, decline. So we take that information and take it into our intervention piece. Now for the intervention piece, you know, this is a 15, 20 minute podcast. We have a whole week on this in our NYA Level 2 course. But what you need to know is there are three things that are really, really important if osteoporosis is on board. One is balance training. This doesn't directly impact bone mineral density, but if we're able to improve people's balance capacity, I would even go as far to say their fall capacity as well. Do they know how to land? Do they have the balance capacity to even prevent the fall? That whole conversation of falls prevention and falls preparedness that we speak to, particularly in our live course, is really helpful for these individuals. Because if we can prevent a fall or even teach people how to fall in a more efficient or safer manner, you can potentially prevent an injurious fall or an osteoporotic-related fracture. So that's the first thing. Second thing is progressive resistance training. Bones really like progressive resistance training, where we're working up to relatively higher percentages of a one rep max, 70, 80, 85%. We're not going to come out the gate hitting that, but it'll take some time. But there's some really promising studies showing that, man, if people are able to regularly train at those higher intensities, they get really strong. They improve in a lot of the functional outcome measures that we care a lot about, but also their bone mineral density as well. Lyftmore trial is a great example of one group that's been able to show that. And then probably one of the more neglected things that we can definitely implement that can be intimidating for a lot of folks, but I found a lot very empowering for patients once they're able to do these things, and that is impact training. Weight-bearing as well. Loading the bones, but really thinking about the rate of loading. Progressive resistance training puts a ton of force, a bunch of load through that skeletal system that gets really good results. But bone can also respond really well to rapid loading. So think like plyometrics, stomping, heel stomps. step-ups, maybe a plyometric push-up, for example, or a quick bearing of weight through the upper extremities, something along those lines, where we're getting those increased ground reaction forces, we're getting those impact that can give the bones a signal to remodel. You take balance training, you take falls preparedness, sprinkle in some progressive resistance training, and then sprinkle in some of that impact training, and you stretch that out over years, And I will put my money that you're going to see some solid results when your patient comes back and says, Oh my gosh, Alan, look at my DEXA scan I just got. Remember the previous year, about a couple of years ago is like right when we started working together. And then man, I just had this DEXA scan and I've reversed my osteoporosis. We've seen that. Not to say it's going to happen every time, but people have the capacity to change and we often don't perceive that with this particular diagnosis. It is not a death sentence. There's a lot we can do. So understand the diagnosis, but then also understand that prognosis and give your patients context. Get that DEXA scan, look at it, analyze it. It's going to give you a lot of helpful information that they may not have comprehended and it can ease their mind of a lot of concern and worry, but it can also give them, something that they know they can do. And we can take that information and give a targeted intervention to a particular area that may be more troublesome than others. But man, if we combine that balance training, falls preparedness, progressive resistance training, and impact training with folks over a long duration of time, we can see some really significant results. All right, y'all. I appreciate y'all taking the time to listen. Let me know if you have any thoughts, questions, or your experiences working with folks. I do want to make sure I'm not saying everyone's going to get better. Everyone's going to improve their bone metal density. That is not the case. But man, if we can try without causing more harm, I think that's a good thing to pursue. And oftentimes, we can see some improvement. SUMMARY Before I go, I do want to mention our MMOA courses. I already mentioned that level 2 where we talk a lot about osteoporosis. Our online level 1 course is starting May 15th. Our level 2 course is starting May 16th. These are both 8 weeks long, about 2 hours a week, so you'll get 16 CEUs for PT, OT. and we equip you all to be the go-to clinician to best serve older adults in your community. It's likely gonna make you a very, very busy clinician serving these folks. And then our live course, we're gonna be in Bismarck, North Dakota, in Richmond, Virginia on May 18th and 19th. I'm gonna be in Scottsdale, Arizona, the beginning of June 1st and 2nd, and then we'll be in Spring, Texas, June 8th and 9th. We'd love to see y'all on the road or see y'all online. Y'all have a lovely rest of your Wednesday and go check out those Texas games. See y'all! OUTRO Hey, thanks for tuning in to the PT on Ice daily show. If you enjoyed this content, head on over to iTunes and leave us a review, and be sure to check us out on Facebook and Instagram at the Institute of Clinical Excellence. If you're interested in getting plugged into more ice content on a weekly basis while earning CUs from home, check out our virtual ice online mentorship program at ptonice.com. While you're there, sign up for our Hump Day Hustling newsletter for a free email every Wednesday morning with our top five research articles and social media posts that we think are worth reading. Head over to ptonice.com and scroll to the bottom of the page to sign up.

Host Jennifer Sanasie breaks down the latest news in the crypto industry from JPMorgan's new report on bitcoin's positioning to the latest update on Do Kwon's South Korea extradition.To get the show every day, follow the podcast here."CoinDesk Daily" host Jennifer Sanasie breaks down the biggest headlines impacting the crypto industry today, including a new report from JPMorgan that says bitcoin still looks overbought despite the recent sell-off. Plus, the latest on Do Kwon's South Korea extradition and Frax's singularity roadmap that aims to boost the TVL of its layer 2 to $100 billion.-Consensus is where experts convene to talk about the ideas shaping our digital future. Join developers, investors, founders, brands, policymakers and more in Austin, Texas from May 29-31. The tenth annual Consensus is curated by CoinDesk to feature the industry's most sought-after speakers, unparalleled networking opportunities and unforgettable experiences. Register now at consensus.coindesk.com.-This episode was hosted by Jennifer Sanasie. “First Mover” is produced by Jennifer Sanasie and Melissa Montañez and edited by Victor Chen.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

KSQD 2-28-2024: A new drug for endometriosis pain is long overdue -- endometrial microbiome is discussed; Active release therapy for the psoas tendon; Side effects of long time use of Finasteride for prostate hypertrophy; Keeping off the weight you lose from semaglutide drugs requires exercise and diet; The complex issue of mycotoxins in the environment and your body; Questions about the FRAX score for osteoporosis; How to treat SIBO

Dr. Julie Brauer // #GeriOnICE // www.ptonice.com  In today's episode of the PT on ICE Daily Show, Modern Management of the Older Adult lead faculty Julie Brauer discusses the importance of fracture risk screening & osteoporosis management, including utilizing the FRAX tool & DEXA scans to better help assess & manage fall risk with patients. Take a listen to learn how to better serve this population of patients & athletes, or check out the full show notes on our blog at www.ptonice.com/blog. If you're looking to learn more about live courses designed to better serve older adults in physical therapy or our online physical therapy courses, check our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab. EPISODE TRANSCRIPTION INTRODUCTION Hey everyone, this is Alan. Chief Operating Officer here at ICE. Before we get started with today's episode, I want to talk to you about VersaLifts. Today's episode is brought to you by VersaLifts. Best known for their heel lift shoe inserts, VersaLifts has been a leading innovator in bringing simple but highly effective rehab tools to the market. If you have clients with stiff ankles, Achilles tendinopathy, or basic skeletal structure limitations keeping them from squatting with proper form and good depth, a little heel lift can make a huge difference. VersaLifts heel lifts are available in three different sizes and all of them add an additional half inch of h drop to any training shoe, helping athletes squat deeper with better form. Visit www.vlifts.com/icephysio or click the link in today's show notes to get your VersaLifts today. JULIE BRAUER Welcome to the Geri on Ice segment of the PT on Ice Daily Show. My name is Julie Brauer. I'm a member of the Older Adult Division. Excited to be talking to you all this morning all about the big critical piece that is missing from our fall prevention and management frameworks. The big critical piece that is missing from our fall prevention and management framework. So before we get into the goods, I want to let you all know about our courses that are coming up in January because we are hitting the new year just right out the gate. We are absolutely slammed. So our L1 and L2 online courses kick off January 11th and January 12th. And then we will be on the road all throughout the month. So we will be in Columbus, Ohio, We will be in Santa Rosa, California, Clearwater, Florida, and Kearney, Missouri. So we would love to see you in our online courses or out on the road starting the year off strong with us. FRAMEWORKS FOR ASSESSING FALL RISK Okay, let's dive in. I want you all to think of your typical frameworks for your fall risk assessment and your management plan. I want you to think about it. So I want you to think that 70 year old Betty is coming into your clinic or you're going to see her at her home or in her hospital room. She's been referred for strength and balance deficits. She's had a fall in the past. I want you to think about kind of that long list of assessment pieces that come into your head. You know, what you're probably going to evaluate or be thinking about. So when I think about that long list, here are some of the things that come to my mind that are probably coming to your mind. You may do some evaluations and assessments like the short physical performance battery. You may run a tug. You may look at strength. You're probably going to do a gait speed. Maybe you want to do a mini best and check Betty's vision, check her cognition, talk to her about her environment. Maybe you do a medication review or you check her shoe wear. Maybe you're going to check her vitals, right? This list could go on and on. It's definitely not all inclusive, but I would bet that a large percentage of you that for a large percentage of you, the piece that didn't make that list was fracture risk screening and osteoporosis management. FRACTURE RISK SCREENING & OSTEOPOROSIS MANAGEMENT This is our critical missing piece, fracture risk screening and osteoporosis management. So we are going to start by setting the foundation and talk about why that piece is commonly missed. We are going to talk about why as fitness forward rehab professionals, fracture risk screening and osteoporosis management has to be on our radar, especially given the fact that we have the goal, especially in this crew, we have the goal of identifying, seeking out, and absolutely destroying one ret max living in order to make our older adults as robust as possible. And in this specific case, helping to make their bones as robust as possible. And then I will give you guys a few clear, easy to implement actionables that you can start getting after this week that are going to be able to give you a very comprehensive clinical picture of your patient's skeletal health. Okay. So first and foremost, we need to think about why is this not on our radar? You know, why for many of us was fracture risk screening and osteoporosis management not something that came to our minds. And if you're like me, I didn't really learn about that in school. It wasn't emphasized. I definitely didn't learn it out on clinical. And I really didn't address it in my clinical practice. If someone, one of my patients had osteoporosis, I kind of just assumed that it was going to be managed by their PCP or the medical team. And I didn't really have a big role to play, right? And we also have to realize that we understand that falls and fractures are important, right? Like falls and fractures, especially in working with older adults, this is on our mind a lot. And we know that as our older adults age, falls and fractures are going to increase. And we know that This results in years and years and years of disability that our older adults have to live with. So we know that it's important. So we have to start thinking like, why isn't this on our radar? So I want you all to start getting really curious about your patient's skeletal health. And when we look to the literature, we further see that this is an undertreated and an underdiagnosed condition. In the literature, it'll be deemed as the silent disease. And there are so many retrospective cohort studies that show that individuals who sustain a fracture after a fall, a very alarming high percentage of them were never scanned. They never had a DEXA scan. They were not on osteoporosis medication. And a very high percentage of them will go on to have another fracture in a few years. So this is a massive, massive problem that we are seeing and we have to realize that we have a role here and we can be the individuals to help screen and identify this as a problem and interrupt that cycle. So when we start to get curious about our patient's skeletal health, I want you all to think about Betty, right? About 75-year-old Betty who's coming in to see you. And we're really good at looking at Betty and assessing Betty and thinking, like, Betty's got a lot of muscular weakness on board. So if we know that Betty is weak muscularly, we have to remember that it's called the musculoskeletal system, and that those bones also may be very weak as well. So as soon as you identify muscular weakness in Betty, I want you all to be thinking, okay, I need to start thinking, hmm, are those bones weak as well? The other side of this, though, is that Betty may blow that, you know, 30 seconds to stand out of the water. Her gait speed may be great. Like she's really kind of crushing it on her on these outcome measures that we're running. And we may think like, oh, she's thriving. However, we can't automatically assume that those bones are thriving as well because there are so many factors that go into bone health that are not visible to the eye. So don't make the assumption that her skeletal system is absolutely crushing it. You want to continue to be curious and you have to start thinking there's so much more that goes into this. I need to do some assessments and do some screening to really get a clinical picture of what Betty's skeletal health is actually like, right? And we need to start thinking about this in terms of urgency. In the older adult division, the urgent situation is identifying someone who is at one rep max living, and then triaging our fitness forward approach, because that individual needs our fitness forward approach the most. So if you think about it, and Betty is coming in, and you're running assessments on her, and she's at risk for falls, and you haven't even looked at her skeletal health yet, Well, you're going to say, whew, Betty's at risk for falls. I definitely need to really triage a fitness board approach for her. But then if you also assess her skeletal health and you realize that she has weak bones and she's at risk for falls, my God, that is an incredibly, incredibly urgent situation. That individual needs our fitness forward approach the most, but we're not going to be able to know how to intervene, how to appropriately intervene if we don't even know the problem exists. So we have to be able to identify that this is a problem. We are the providers that can make this silent, invisible disease very visible. So how do we do that? Let's talk about some actionables here that you guys can start doing immediately that are going to be able to give you really critical data in order to gain a comprehensive picture of her skeletal health. Number one, it is the lowest hanging fruit. It's the easiest place to start. SCREENING FOR FRACTURE RISK: THE FRAX TOOL You can screen for fracture risk and you can do that by using the FRAX tool. The FRAX tool is so easy, so quick to implement. I will link it here for you. It takes two minutes, but the algorithm gives the 10-year probability of a fracture. So it's gonna give the 10-year probability of a hip fracture and the 10-year probability of a major osteoporotic fracture, so of the spine, forearm, hip, or shoulder. In the questionnaire for the FRAX, ask some questions that start giving you an idea of things that affect bone health. So really easy, they're going to be asking just age and height and weight, right? These things you can get from EMRs or your patient. really quickly and then they're going to be asking some questions like have they had a previous fracture? Did one of their parents fracture a hip? Are they smoking? Are they on medications like glucocorticoids? Do they have an inflammatory disease like rheumatoid arthritis? Do they drink excessive alcohol? All of these factors that can really affect our bone health negatively. It will also ask for their bone mineral density. And you do not have to have Betty's bone mineral density in order to fill this out and for it to be to give you a validated probability. The frax has been validated without a bone mineral density value. However, Betty may have her bone mineral density. She may have a DEXA scan, and you can use that value, but only for the femoral neck. It is only validated for the bone mineral density of the femoral neck. So that's the caveat there, right? So really quick and dirty, you can do the FRAX tool. It's going to shoot out a probability. What happens next? This is going to start to give you an idea, like, whew, there's a lot going on here that I didn't realize with Betty. Her skeletal health isn't really thriving. And let's assume that Betty has not had a bone mineral density scan. And you're really thinking, well, I mean, gosh, she smokes, she's been on glucocorticoids, she drinks alcohol, she has had a previous fracture, like, she should probably get a DEXA scan. and you're thinking like, but you know, what are some, like, should I suggest that? The great news is that there are guidelines that tell us if we should suggest that Betty get a bone marrow density scan. I will link the clinician's guide to prevention and treatment of osteoporosis as well for you all to look at, but it just gives some general guidelines. A lot of the things that you have just heard about from the FRAX tool. So, it will tell us that we should consider BMD testing if with individuals based on age, based on the clinical risk factors such as taking glucocorticoids or having an inflammatory disease, individuals who have had a fracture. So we have guidelines to tell us this. TESTING FOR OSTEOPOROSIS So You've run the FRAX tool, you've looked at the guidelines, you are sure, you're like, Betty needs to go get a DEXA scan. So you're gonna communicate this to Betty. But what you're gonna do next is not, hey Betty, I really want you to go get those bones looked at. So schedule that with your doctor. I'll see you next week. That's not what we're gonna do. you're gonna help Betty set that appointment up or call a doctor, right? You are going to help her advocate for herself. You're not just gonna give that piece of education and then peace out, Betty. So what can you do? You can get the doctor on speakerphone during your session with Betty. and you can guide the conversation while she asks to set up an appointment to get a DEXA scan done. You can make sure Betty knows how to get into her MyChart so she can send a message to her doctor and you can help guide her on how she should formulate that message so she's communicating effectively. Make sure that you are a guide during that process and that you're not just throwing an educational piece at her and expecting her to take care of it. Help her through the process. Okay, so let's say we got a DEXA scan scheduled for Betty and she goes and has her appointment. She gets her DEXA scan. She has her results. This is where you can have a major role, not only in helping to deal hope to Betty once we are looking at those results, but it's also gonna be your guide when you start to implement your interventions. And it gives you very critical information, okay? So if you all have not seen a DEXA scan in the wild and what that looks like, I'm gonna tell ya, it's not patient friendly. I have seen one after my mom had to get one before she had a lumbar fusion surgery. It is chock full of scary words like osteopenia, fracture, osteoporosis. There's a lot of negative values, right? Like her T-scores all over the place and there's these negative numbers. It'll say increased risk for fracture. It is not easy to comprehend. and it deals a lot of fear. So this is an opportunity to help Betty interpret what this means. And you can really offer a lot of hope here. So with the DEXA scan, right, and with this data, you can be looking at it, and it's gonna give you that T-score, right? Betty may be looking at this and be like, oh my gosh, this number is so low, this is awful, right? I'm so scared. you can deal hope because you know, based on the law of initial values, those lower T-scores are going to respond to bone loading the best. They're gonna have the best result from starting to load those bones up. That's an amazing thing. You can share that news. So even if that T-score is really low, you can say, Betty, that's all right. That low score, those bones, you're gonna respond the best. And together, we're gonna help get those bones stronger. So right away, you can start dealing some hope. It's also going to tell you where those low T-scores are. The location of where the osteopenia or osteoporosis is is incredibly critical. How many of you have had patients come into your clinic and say, I can't lift that because I have weak bones? And you know, Betty, if it was Betty, she may assume that her weak bones are all over the place. However, that DEXA scan could tell you that the only place where she has weak bones is in her radius. Okay, well, all those squats and the jumping and things that Betty's like, absolutely not, I can't do, they're kind of irrelevant because it's in her radius and not in the legs, right? So to help Betty alleviate some of that fear, you could reassure her where those weak bones are. And that could really work in your favor when you're trying to get her to buy in to do exercise. However, you are also thinking, I need to know where and where is important because you know that bones are going to adapt specifically to where load is put on them. So let's say the low T score is in Betty's hip. You know that you have to load that hip up in order for that bone mineral density to increase. However, you also are taking this information and being cautious to say where it is so that Betty knows, yes, it's weak here. She may be a little apprehensive to load that area. So you know that you can give her the hope of, hey, it's weak here, but your bones are strong in these other places. So we can start loading where those strong bones are. So you can gradually expose her and mitigate some of the fear she may have. The other piece of information that is really important from the DEXA scan that you get as a provider is that it just gives you the severity, right? How low is low in that T-score? Because that is going to determine your rate of loading progression. So you have to know, hey, maybe this is someone where we are not going to start with impact exercises, we're going to start with just resistance exercises. And maybe I'm going to modify where I place that weight based on where that low T-score is. And maybe if we do start impact, or when we start impact, it's going to be upper extremity assisted versus just having Betty do jumping right away. So it's incredibly important so you know where the entry point is of appropriate and safe loading. So the bone mineral density scan, helping Betty interpret that information and you using it as a guide, sets you up to be able to appropriately intervene and start loading those bones up. All right. That is it, that is what I got for you all. I want you to start getting really curious about your patient's skeletal health, and then get after these two easy actionables. Run the FRAX tool, advocate for a bone mineral density test. Once you get the DEXA scan and you get that information, interpret that with Betty, use that as your guide, use it to deliver hope to Betty. After that, it is off to the races with your loading interventions. this framework of how to manage osteoporosis. This is one small piece. We expand on this so much greater in our L2 course. We talk about medical management. We talk about further into guidelines and how to load and what's appropriate to load. And we dig into the research. We would love to see you in that L2 course so that you all can really get a comprehensive really get comprehensive knowledge of how to manage this condition. In our live course, we have an entire lab focused on impact training, so it gives you all the ideas, all the ideas. You get to try them out of how to initiate bone loading for your athletes who are seated and they are non-ambulatory, they're in wheelchairs, all the way up to a very high, highly active older adult. That's what I got for you guys. I would love to hear if you all run the Fractual this week or interpret your patient's DEXA scan with them. I would love to hear how that goes. Have a wonderful rest of your Wednesday. OUTRO Hey, thanks for tuning in to the PT on Ice daily show. If you enjoyed this content, head on over to iTunes and leave us a review, and be sure to check us out on Facebook and Instagram at the Institute of Clinical Excellence. If you're interested in getting plugged into more ice content on a weekly basis while earning CUs from home, check out our virtual ice online mentorship program at ptonice.com. While you're there, sign up for our Hump Day Hustling newsletter for a free email every Wednesday morning with our top five research articles and social media posts that we think are worth reading. Head over to ptonice.com and scroll to the bottom of the page to sign up.