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Welcome to Off the Beaten Clef! This week, we dig into the iconic guitar video game of Guitar Hero. We discuss the background of the video games, the evolution from GH1 to GH2, and into GH3: Legends of Rock. We also draft 3 of our favorites from each game - for a mixtape of 18 songs total! The playlists for our picks will be below on Spotify and Apple Music. What are your favorite memories from Guitar Hero? What songs were left off the list? Let us know on social media / discord! To listen our Guitar Hero Mixtape on Spotify / Apple Music OTBC Social Media: Instagram - @offthebeatenclef // Twitter - @OffClef // Email - offthebeatenclef@gmail.com // TikTok - @otbc.podcast // Discord - Link HERE Thanks for listening!
In 1D Talks: Episode 31, Dr. Todd Lee - IFBB Pro, joins Joe and Justin to discuss bodybuilding, anabolics, testosterone, liquid T4, hormone health, family life, and funny opinions!1:10 - Introduction/How did Justin meet Todd4:39 - Ken Jackson6:30 - How did Justin meet Todd continued, and Todd working with different coaches12:50 - Hard working mentality in a prep15:40 - John's prep and peak week protocols16:24 - Todd's competition plans17:37 - Todd's cardio regiment20:20 - Circadian rhythms could be different for everyone23:45 - Todd's tips for better sleep27:20 - Tiktok's algorithm28:27 - Sunlight after waking up30:00 - Hot ball theory33:40 - T4 and growth hormone36:04 - Raloxifene37:20 - Aromatase inhibitors for breast cancer40:25 - Steroid pathways43:23 - How does Todd deal with erectile dysfunction 46:40 - Tren leading to higher prolactin50:35 - Hard to conduct studies on hormone intricacies 51:41 - ED54:13 - Todd using Melanotan 56:15 - Todd's protocol and thoughts for Ozempic 58:14 - Research on reps in reserve vs training to failure1:00:18 - Everybody demonizing steroids and the benefits of steroids1:00:04- Nandrolone only cycles1:06:30 - Justin's approach to steroids1:09:20 - Intermission1:10:53 - T4 and GH1:14:05 - T3- Follow Dr. Todd and Learn About His Services- Subscribe to Dr. Todd on YouTube.- Hosted by Joe Miller and Justin Harris of 1st DetachmentSupport the show** DISCLAIMER **The content on this channel is for entertainment and educational purposes only. 1st Detachment does not provide, endorse, or promote specific medical providers. We do not make warranties to its accuracy, application, and completeness. Our guests share their opinions and views on a variety of complex topics. Always seek advice from qualified medical practitioners. Do not disregard medical advice or delay seeking medical treatment due to the information presented on this channel.Consult with a physician before taking any over-the-counter medications, supplements, or herbs. This channel does not endorse medications, vitamins, or herbs, nor do we condone the use of illegal drugs.Consistent with community guidelines, we do not glorify the use of illegal drugs or the consumption of drugs illegally. A qualified medical professional should make decisions with each patient's health profile, current prescriptions, and medical history in mind.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.14.339028v1?rss=1 Authors: Baiya, S., Pengthaisong, S., Ketudat Cairns, J. R. Abstract: Monolignol glucosides are storage forms of monolignols, which are polymerized to lignin to strengthen plant cell walls. The conversion of monolignol glucosides to monolignols is catalyzed by monolignol {beta}-glucosidases. Rice Os4BGlu18 {beta}-glucosidase catalyzes hydrolysis of the monolignol glucosides, coniferin, syringin, and p -coumaryl alcohol glucoside more efficiently than other natural substrates. To understand more clearly the basis for substrate specificity of a monolignol {beta}-glucosidase, the structure of Os4BGlu18 was determined by X-ray crystallography. Crystals of Os4BGlu18 and its complex with {delta}-gluconolactone diffracted to 1.7 and 2.1 [A] resolution, respectively. Two protein molecules were found in the asymmetric unit of the P 2 1 2 1 2 1 space group of their isomorphous crystals. The Os4BGlu18 structure exhibited the typical ({beta}/) 8 TIM barrel of glycoside hydrolase family 1 (GH1), but the four variable loops and two disulfide bonds appeared significantly different from other known structures of GH1 {beta}-glucosidases. Molecular docking studies of the Os4BGlu18 structure with monolignol substrate ligands placed the glycone in a similar position to the {delta}-gluconolactone in the complex structure and revealed the interactions between protein and ligands. Molecular docking, multiple sequence alignment, and homology modeling identified amino acid residues at the aglycone-binding site involved in substrate specificity for monolignol {beta}-glucosides. Thus, the structural basis of substrate recognition and hydrolysis by monolignol {beta}-glucosidases was elucidated. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.15.252114v1?rss=1 Authors: Prakash, O. Abstract: Protocol established and validated for clustering of non-unified protein sequences through memory-map guided deep learning. Data evaluated belongs to the disease causing proteins/genes from human hormonal system. Possibilities for future experiments validation was found for genes as: ACTHR, AGMX1, ATK, BPK, DPDE3, ERBA2, FSHB, GH1, GHSR, GNAS1, GSP, HANF, LCGR, LGR2, LGR3, LHRHR, NR1A2, PKR1, PRKAR1, RNF216, SBP2, SECISBP2, THR1, THRB, TPIT, TRIAD3, TSE1, UBCE7IP1, XAP2, and ZIN. Protocol is recommended for implementation with small to large dataset (protein/ DNA/ RNA sequences of unified or non-unified length) with unclassified data flags. Copy rights belong to original authors. Visit the link for more info
I have launched my own radio station - We Get Lifted Radio! https://www.wegetliftedradio.com We play house music for you every day.. deep house, soulful house, afro house, jackin house, progressive house, and even trance! I have a GREAT team of DJ's as well as global shows from Jesse Saunders, GOGO Music Radioshow, Traxsource Live, Armada Radio, Roger Sanchez Release Yourself and trance shows such as Transmission, Suzanne Chesterton and more. Regular DJs include Marvin Sykes Presents Syked, Daniel Waite from Fixate playing progressive house, my team members DJ K-Smoov and Stevie B from Philly. From Canada we have DJ BossRoss and Naturevibes. The soulful and afro DJs - Mickey Cee, GH1, Vibe Providers, Ples Jones, Craig Twitty, House Matters, Soulful Masters (SA), Ben Brummitt, DJ Flyer. We have the deep house guys - Col Lawton, OUD (Hu), John Ludo and Lee Thomas playing across the genres, Kontrolfreaks with their tougher sounds. From Hawaii with have Meeshu with his chilled Surf's Up Soundsystem. We are having a massive trance night this Saturday 13th February from 9pm (GMT). You won't want to miss it! Come and join us, you can chat with us about the music if you want to. https://www.mixlr.com/we-get-lifted This is the first of a series of mixes from We Get Lifted Radio, this one is from me, Lady Duracell, and there will be more soon from the other DJs. LD x https://ladyduracellqueenoffunk.podomatic.com http://www.ladyduracell.com https://www.wegetlifted.com https://www.wegetliftedradio.com http://www.facebook.com/LadyDuracellDJ http://www.facebook.com/groups/ladyduracell http://twitter.com/LadyDuracell Get Lifted Clothing: http://www.JackFresh.com
In This Episode... In Segment 1, Keith tells Rod about his new stuff such as his sensor cleaning techniques and tools like the Eyelead SCK-1B, his Rokinon 12mm E-Mount and Rokinon 16mm full frame lenses, and his new Fotodiox Fusion ND Throttle Auto EF to E Mount adapter. Then in Segment 2, Keith tells Rod about his 4K data explosion dilemma and how to deal with his mounting data storage needs with drives like his new Mobius 5-bay RAID enclosure, the new Seagate 8TB Expansion Desktop Drive, and Softraid. Then in Segment 3, Keith and Rod discuss 3 new and one newish Canon Cameras, the 5Dmk4, the XC15, the C700, and the C300mkII price drop. In Segment 4, Keith tries to talk Rod off the ledge of ditching his GH1 in favor of something like the Sony A7rii or A6300. Will Rod take the plunge? Rod and Keith wrap up Episode 33 with a philosophical discussion "Is Micro Four Thirds Dead?" Please remember to support TechMove – it’s easy and doesn’t cost you anything, just go to techmovepodcast.com/amazon.
TRENDING TOPIC SEGUNDA TERCERA POSICIÓN Iñigo González GH1 infiltra al Vuelo714 en la fiesta previa a la boda de Jorge Berrocal GH1. En ese improvisado asalto a la intimidad de Jorge y sus amigos, los voladores disfrutamos de la magia del directo con la crónica de Jorge acerca de GH17 y su presentador y luego con la de Iñigo (reportero del vuelo por un dia). Nos hablan de su paso por la gala de GH17, de Mercedes Milá y de J.J.Vázquez. No lo aparentaba pero Jorge estaba en "capilla" e iñigo a su lado como buen compañero. Solo la generosidad de los dos permitió que todos los voladores compartieramos esos momentos tan importantes en directo. A estas horas Jorge ya tendrá esas dos piernas tan aclamadas por él encima, y para siempre si dios y la providencia lo permite. Manu vuelve a recitar su maestría cinematográfica glosando las excelencias del la cinematografía de bolliwood. El programa obtiene una SEGUNDA posición en las tendencias de twitter España y consigue un trending topic TT2 a escasos metros del TT1 de sálvame, en ese momento en emisión y compitiendo con el vuelo. Otra medalla más para los voladores que calentaron el HT #Vuelo714N65 como nunca.
Background: Since the times of domestication, cattle have been continually shaped by the influence of humans. Relatively recent history, including breed formation and the still enduring enormous improvement of economically important traits, is expected to have left distinctive footprints of selection within the genome. The purpose of this study was to map genome-wide selection signatures in ten cattle breeds and thus improve the understanding of the genome response to strong artificial selection and support the identification of the underlying genetic variants of favoured phenotypes. We analysed 47,651 single nucleotide polymorphisms (SNP) using Cross Population Extended Haplotype Homozygosity (XP-EHH). Results: We set the significance thresholds using the maximum XP-EHH values of two essentially artificially unselected breeds and found up to 229 selection signatures per breed. Through a confirmation process we verified selection for three distinct phenotypes typical for one breed (polledness in Galloway, double muscling in Blanc-Bleu Belge and red coat colour in Red Holstein cattle). Moreover, we detected six genes strongly associated with known QTL for beef or dairy traits (TG, ABCG2, DGAT1, GH1, GHR and the Casein Cluster) within selection signatures of at least one breed. A literature search for genes lying in outstanding signatures revealed further promising candidate genes. However, in concordance with previous genome-wide studies, we also detected a substantial number of signatures without any yet known gene content. Conclusions: These results show the power of XP-EHH analyses in cattle to discover promising candidate genes and raise the hope of identifying phenotypically important variants in the near future. The finding of plausible functional candidates in some short signatures supports this hope. For instance, MAP2K6 is the only annotated gene of two signatures detected in Galloway and Gelbvieh cattle and is already known to be associated with carcass weight, back fat thickness and marbling score in Korean beef cattle. Based on the confirmation process and literature search we deduce that XP-EHH is able to uncover numerous artificial selection targets in subpopulations of domesticated animals.
Episode 2 of the Digital Convergence Podcast by 16x9 Cinema with host Carl Olson - a visual artist, photographer, and videographer based in the Atlanta, Georgia, USA, area. In episode 2, I talk to Bruce Sharpe, founder and CEO of Singular Software - the source of the amazing application PluralEyes. PluralEyes saves hours in post-production for multi-camera edits, dual-system audio or multi-take workflows such as music videos. It automatically synchronizes all your audio and video clips without the need for timecode, clappers or any special preparation. In this episode, Bruce talks about the origin of PluralEyes, offers some helpful tips for hybrid DSLR videographers, and reveals exciting news on how you can be the next James Cameron with a pair of hybrid DSLR cameras.
I went out for a rollerblade on the lakefront. When I got there I saw that the paths were absolutely packed. So I took off my skates and did some prospecting with the Panasonic GH1. This is the footage that came out of it.
The new Zoom H4n gives DSLR camera operators the option to shoot video and sound with equal consideration