Podcasts about steroids

Donna Yaklich alleged that her police detective husband repeatedly abused her, threatened her life and left her believing there was nowhere she could safely turn. Then she recruited two young men to kill him. David Lascher joins Elisa Donovan to revisit the shocking case behind Cries Unheard, why the movie was far more brutal than he remembered, and the complicated question at its center: What happens when a victim of abuse becomes responsible for a crime herself?See omnystudio.com/listener for privacy information.

Is it eczema or Topical Steroid Withdrawal (TSW)?In this episode, Julia explains the differences between eczema and Topical Steroid Withdrawal, the symptoms they share, what makes them different, and what to do if you suspect TSW.Julia also shares her own experience dealing with both eczema and TSW.She covers:What is eczema and how it presents What Topical Steroid Withdrawal (TSW) isCommon TSW symptomsHow to tell eczema and TSW apartJulia's personal experience with bothWhat to do if you suspect TSWITSAN: https://itsan.orgWork with Julia:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book a Free Consultation⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book a 1:1 EFT Tapping Session with Julia⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Julia on her social⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠@juliachien.rd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!

Why do steroids stop producing the same gains over time? In this episode of Drugs N Stuff, Scott McNally and Dave Crosland explain why simply running more drugs for longer eventually leads to diminishing returns—and how experienced bodybuilders structure long growth phases to keep making progress. Plus, we answer your questions on testosterone isocaproate, DHB, Dutasteride, Retatrutide, NAD+, P-21, sauna use, TRT injection frequency and much more. ⏱ TIMESTAMPS 0:00 Why Steroids Eventually Stop Working 1:00 Support Our Sponsors 3:45 How to Plan a 12-Month Growth Phase 13:40 Start Low, Build Slowly & Extend Your Cycle 20:30 Testosterone Isocaproate Half-Life Explained 24:10 Can You Re-Sensitize Yourself to Stimulants? 29:40 Scott's Experience with P-21 31:40 Selank: Scott's Honest Experience 32:50 Low-Dose Testosterone + DHB for a Specific Look 37:00 Sauna Benefits While Using PEDs 41:00 Can Retatrutide Reduce Addiction? 45:00 NAD+ Benefits & Can You Overdo Mitochondria? 48:45 Why Some Lifters Are Leaving Daily TRT Injections 49:45 Does Dutasteride Protect Against Dianabol Hair Loss? 51:50 Why Hydrochlorothiazide Is NOT Potassium Sparing 54:30 LSD as a Treatment for Depression 56:00 Uncle Dave's Wisdom 1:04:00 We Need to Buy Dave a Horn Check out all our affiliates at http://www.thinkbigbodybuilding.com UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

Andy Schectman rejoins the Economic Review to discuss what may be one of the most important financial stories being overlooked by the media: the extraordinary surge in gold demand from sovereign wealth funds, central banks, and governments around the world.While publicly released figures already indicated that official-sector demand had reached historic levels, Andy explains that subsequent revisions to those numbers suggest the true scale of accumulation was dramatically larger than originally reported.Sarah and Andy explore what this could mean for the global monetary system, the future role of the U.S. dollar, and why governments and large institutions may be positioning themselves for significant changes ahead. If sovereign buyers are moving aggressively into gold while public attention remains focused elsewhere, the question becomes: what are they seeing that the rest of the world is missing?Andy argues that the combination of gold's price behavior and the secretive nature of the purchasing activity suggests purposeful misdirection designed to obscure the true scale and significance of what is occurring. He believes these developments point to profound shifts taking place beneath the surface of the global financial system that deserve far more scrutiny than they are currently receiving.

Kill your vices, sculpt your physique, and become unstoppable with my FREE 6-Step Daily Domination Blueprint. CM Punk is on steroids?! Let the lazy nitwits tell it.  Find out the real "secrets" that separate the best in the world from everyone else, what to eat at every meal, how to increase athleticism, and more, in today's Q&A... Is there a trick for visible abs? [4:13] What to eat at every meal to look, feel, and perform your best. [7:34] Does too little fat crash your hormones? [11:53] Should you do isolation work before compound exercises? [14:56] What's the formula for increasing athleticism? [18:53] These character traits separate the best in the world from everyone else. [21:26] Sponsors LMNT: Restore health through hydration, and get a free sample pack at drinklmnt.com/renegade. Cured Nutrition: Use code RENEGADE at curednutrition.com and save 20% on the highest quality CBD products. Want to work with me to transform your body and mind? Go here now.

T3 + Vitamin A = LDL + Pregnenolone = All Sex Steroid Hormones The Critical Biochemical Pathway Most People Never Learn About In this episode of the Improvement Warrior Podcast (Substack, Apple), Jason Yun breaks down a critical biochemical pathway: how T3 (the active form of thyroid hormone) works with Vitamin A to help utilize LDL cholesterol, which then supports the production of pregnenolone — the precursor to all sex steroid hormones (testosterone, estrogen, progesterone, etc.). Jason explains the interconnected roles of these molecules in energy production, hormone balance, fertility, mood, and overall vitality. He connects this pathway to his core teachings on circadian biology, mitochondrial health, and the importance of proper light exposure. The discussion highlights why disruptions in this chain are common in modern life and offers practical insights into supporting it naturally through lifestyle, nutrition, and environment. Whether you're dealing with low energy, hormonal imbalances, or simply want to understand how your body produces and regulates sex steroids at the deepest level, this episode delivers clear, actionable knowledge rooted in real biology rather than conventional approaches.Timestamp Log 0:00 – Intro & welcome to Episode 891:10 – Overview of the key pathway: T3 + Vitamin A3:45 – Role of LDL Cholesterol in the process6:20 – Pregnenolone as the mother hormone9:00 – How this leads to all sex steroid hormones11:30 – Practical implications for energy, hormones & vitality13:45 – Ties to circadian biology, light exposure, and mitochondria15:30 – Key takeaways and action steps16:40 – Closing thoughts & outroResources MentionedImprovement Warrior Newsletter PatreonSubstackOne Tap ZapMagnesium Breakthrough

We discuss the military being on drugs, Tom and Toms vacations this past week, and why diesel is more  than gas  SPONSOR@pioneer_fitpioneerfit.comShow Hosts@tomkal1@huckfinnbarbell@Jacob.w.ross@hfbapparel@letsgetstupidpodcast@officialbebetterbrandletsgetstupidpodcast@gmail.comwww.huckfinnbarbell.comwww.bebetterofficial.com

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Want to see how to turn your phone into a GPS more powerful than the units found on most center console boats? Then you don't want to miss this! Tight lines and enjoy.

The Raven: Mythological Scavengers and Their Modern Return Guest: Stephen Moss Book Title: Ten Birds That Changed the World Ravens, described as "crows on steroids," carry a heavy weight of mythology as independent and highly intelligent scavengers. Associated with Odin's "eyes and ears" in Norse myth and portrayed as harbingers of doom by Shakespeare and Poe, ravens have long held a frightening aura. Their presence on battlefields and in graveyards led to centuries of persecution, particularly in Britain where bounties were paid to protect livestock. Moss dispels myths about the Tower of London ravens, noting they actually left during WWII bombings without the kingdom falling. Despite their sinister reputation, ravens are thriving again in the 21st century, adapting to urban environments and expanding their range. Moss expresses deep respect for these birds, noting they are among the few species that seem "equal to humans" in their independence and refusal to be controlled by our desires. (5)1905 PUPLE FINCH

Dave Crosland and Scott McNally break down the real differences between Anadrol and Winstrol during a contest cut before answering rapid-fire questions on TRT, Tren, HGH, SHBG, estrogen management, Nandrolone for joint pain, cycle design, bloodwork, CGMs for bodybuilding, and much more. 0:00 Anadrol vs Winstrol (Preview) 0:25 Support Our Sponsors 5:00 Anadrol vs Winstrol in a Contest Cut 8:30 Steroid Cycles Around a Rotation Job 13:50 Can P5P Reduce Tren Side Effects? 15:25 What Causes High SHBG? 19:40 CGMs for Bodybuilding: Worth It? 23:30 DIM & Calcium-D-Glucarate for Estrogen 25:45 When TRT Changes Your Life 27:35 Is a 50-Pound Second Cycle Realistic? 32:30 Painful Pharma Testosterone Injections 33:30 Should You Bulk with Tren? 35:00 Kenalog, Allergies & Muscle Growth 37:10 Managing Low Estrogen on Cycle 38:00 Nandrolone for Joint Pain 40:29 ApoB vs HDL: Which Matters More? 43:15 HGH Raw Supply Update 48:00 Switching from NPP to Tren 49:30 Is TRT Microdosing Dying? 51:20 Keeping Testosterone High Off TRT 54:00 When to Kickstart a Cycle 59:25 Bloodwork Options in Canada 1:02:00 Uncle Dave's Wisdom UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

The hormone testosterone is figuring prominently in conversations about the “manosphere.”Politicians and influencers are turning to testosterone and peptides in pursuit of an idealized masculine image.On this hour of All Sides, we're talking about the national obsession with testosterone.We'll meet actor and screenwriter Brock Yurich. His movie Test, filmed here in Ohio, follows one man's personal battle with steroid abuse.Guests: Dr. Benjamin Bring, board-certified physician in family and sports medicine, Ohio Health Brock Yurich, actor, model, screenwriter of the film Test(photo: Jim Norrena Act Out Photography)

The hormone testosterone is figuring prominently in conversations about the “manosphere.”Politicians and influencers are turning to testosterone and peptides in pursuit of an idealized masculine image.On this hour of All Sides, we're talking about the national obsession with testosterone.We'll meet actor and screenwriter Brock Yurich. His movie Test, filmed here in Ohio, follows one man's personal battle with steroid abuse.Guests: Dr. Benjamin Bring, board-certified physician in family and sports medicine, Ohio Health Brock Yurich, actor, model, screenwriter of the film Test(photo: Jim Norrena Act Out Photography)

Looking for a simple, effective PED approach without unnecessary complexity? Coaches Skip Hill, Andrew Berry and Scott McNally break down three of the easiest anabolic cycles to manage, why they chose them, and why Primobolan didn't make the cut for us. Plus, they answer listener questions on TRT backloading, training around knee pain, breaking through plateaus, cycling strategies, reverse dieting and more 00:00 The TRT Backloading Trick (Preview) 00:20 Support Our Sponsors 00:51 Skip Tries to Derail the Show 02:25 NPC Universe Recap 04:15 Why Blood Sweat & Gear Has No Drama 05:30 3 Easy-to-Manage Steroid Cycles 12:40 Why Primobolan Didn't Make the List 14:15 Leg Training Around Knee Pain 30:50 Breaking Through a Muscle Growth Plateau 40:00 TRT Backloading Explained 43:50 One Long Cycle vs Multiple 12-Week Cycles 55:00 Coaching Ethics: Where Do You Draw the Line? 1:03:30 Reverse Diet Gone Wrong: Too Much Fat Gain

The post (P)Steroids & the Psyche: The Problems Nobody Put on the Prescription Label appeared first on JDDonline - Journal of Drugs in Dermatology.

Carpal Tunnel Syndrome – a surprisingly common issue that starts to affect the wrist and hand causing pain and discomfort. What is Carpal Tunnel and how common is it? A nerve compression issue – one of the most common. Pressure on the 'median' nerve as it passes through the wrist It causes numbness, tingling, pain, and hand weakness. Affects around 3–6% of adults, and is more common in women. How do you recognise it? What are risk factors? Gradually notice tingling or numbness in the thumb, index, middle, and ring finger on the palm side. Symptoms are often worse at night, waking people up, or after repetitive use It can cause weakened grip, resulting in dropping objects, and pain using the steering wheel while driving. Those at risk: people who do repetitive work, pregnant people, those with diabetes, obesity, arthritis, or thyroid disease. It's most common in women aged 40–60. How is it diagnosed? Your doctor will take a history and do an examination. They will refer you for nerve test to confirm the diagnosis. An early diagnosis helps prevent permanent damage. What is the treatment? In mild cases, night splints to keep stop the wrist 'flexing' (bending over) while asleep and reducing activity. Manage underlying conditions which aggravate the condition such as thyroid issues, diabetes. Steroid injections can sometimes help. However, people are often referred to surgeon for a simple procedure to cut the ligament in the wrist that compresses the nerve. Most people recover well with excellent long-term results. LISTEN ABOVE See omnystudio.com/listener for privacy information.

The ALL ME® Podcast How Performance-Enhancing Drugs Shape Society – Dr. Charles "Chuck" Yesalis In this in-depth interview, Dr. Charles "Chuck" Yesalis shares his extensive knowledge on anabolic steroids, their impact on youth, and the ongoing challenges in anti-doping education. Discover the history from the 1970's to today, health effects, and societal influences surrounding performance-enhancing drugs. Takeaways: History of anabolic steroids and doping Health effects and risks of steroids Societal and cultural influences on drug use Policy and legal frameworks for drug control Challenges in education and prevention Chapters: 00:00 Introduction and Guest Introduction 00:34 How Dr. Yesalis and Don's Father Met 00:57 Early Concerns About Kids and Performance Drugs 01:24 The 1988 National Study on Youth Steroid Use 02:17 Dr. Yesalis's Involvement in Anti-Doping Efforts 02:59 Personal Motivations and the Loss of Taylor Hooten 03:26 Public Perception and Media Coverage of Steroid Use 03:53 Influence of Social Media and Body Image on Youth 04:25 Risks of Illegal Substance Use Among Young People 04:51 The Push to Gain an Advantage in Sports 05:19 Health Consequences and Long-term Risks of Steroids 05:43 Origins of Dr. Yesalis's Interest in Steroids 06:16 Understanding Anabolic Steroids and Their Effects 06:38 Historical Research and Early Findings 07:32 The Politics and Science of Steroid Use 08:44 Long-term Health Effects and Epidemiological Research 09:37 The Evolution of Performance-Enhancing Drugs 10:28 Credibility and Scientific Evidence in Anti-Doping 11:08 The Impact of Scientific Misconceptions 11:49 Challenges in Education and Public Awareness 12:58 The Role of Legislation and Regulation 13:47 The Influence of Money and Fame in Sports 14:40 Natural vs. Enhanced Performance and Ethical Dilemmas 15:30 Moral and Ethical Issues in Doping 16:26 Athletes' Willingness to Risk Their Lives for Fame 17:23 Obstacles in Anti-Doping Education 18:13 Public Perception and Media's Role 19:13 Generational Changes and Social Media Impact 19:55 Studies on Youth and Steroid Use in the 1980s 21:10 The 1988 Youth Steroid Study Insights 22:25 Public Awareness and Media Coverage of the Study 23:20 Attitudes Toward Risk and Self-Harm in Youth 23:40 Changes in Drug Legislation and Regulation 24:41 The Impact of the Anabolic Steroid Control Act 25:33 Societal Pressures and Body Image Trends 26:38 Current Perspectives on Testosterone and Medical Use 27:41 Descheduling Testosterone and Potential Risks 29:22 Pharmaceutical Industry and Overproduction of Steroids 30:12 Physician Perspectives on Steroid Regulation 31:34 Dependence and Psychological Effects of Steroids 33:03 Risks of Descheduling and Accessibility 34:18 Medical and Anti-Aging Clinics and Steroid Access 37:43 The Book 'Anabolic Steroids in Sports and Exercise' 39:13 Challenges in Fighting Performance-Enhancing Drugs 40:32 Cheating and Ethical Issues in Sports 40:54 Societal Attitudes Toward Winning at All Costs 41:51 Misconceptions and Public Perception of Steroids 43:08 Health Risks of High-Dose Steroid Use 43:59 Behavioral and Psychological Effects of Steroids 45:15 Physician Involvement and Safety in Steroid Use 45:41 The Role of Medical Professionals in Steroid Regulation 47:26 Reflections on Legacy and Impact in Anti-Doping 48:44 The Mission to Shine Light on the Truth 50:25 Final Thoughts and Personal Philosophy Follow Us: Twitter: @theTHF Instagram: @theTHF Facebook: Taylor Hooton Foundation #ALLMEPEDFREE Contact Us: Twitter: @theTHF Instagram: @theTHF Facebook: Taylor Hooton Foundation #ALLMEPEDFREE Email: info@taylorhooton.org Phone: 214-449-1990 ALL ME Assembly Programs: http://taylorhooton.org/education-resources/face-to-face-programs/

FOR EDUCATION ONLY : From testosterone to trenbolone and everything in between, coaches Andrew Berry and Scott McNally rank the most well-known anabolic steroids from S Tier to F Tier based on their experience, discussing their characteristics, limitations, side effects, and role in bodybuilding. This educational conversation is intended to compare compounds—not to encourage their use—and is designed to help viewers better understand the differences between them. 0:00 Tren Ace - The main character compound 0:20 Support the show with the sponsors 1:00 Rate Every Steroid - How the rating system works 2:20 Testosterone 4:00 Masteron Prop and Mast E 9:40 Primobolan 11:55 Nandrolone - Deca 13:50 Nandrolone - NPP 16:25 Trenbolone - Tren Ace 19:50 Trenbolone - Tren E 24:20 Trenbolone - Tren Hex 25:49 Equipoise - Boldenone 31:25 DHB - Dihydroboldenone AKA 1- Test Cyp 33:30 Anavar - Oxandrolone 36:25 Winstrol - Stanozolol 37:50 Anadrol, Superdrol, Halotestin 38:50 Dianabol 41:10 Oral Turinabol 47:45 Listener Critique Check out our Advertisers and Affiliates at http://www.thinkbigbodybuilding.com

Ben and Carlos talk through MLB's proposal to shake up the draft and the international talent acquisition system, working through ramifications for the game, player development, scouting and more. —Time Stamps(0:15) Where have we been?(2:30) MLB's player acquisition proposal(7:00) MLB's dishonest messaging(9:00) Why high school players are more expensive to scout(13:00) Development in pro ball vs. college(16:40) This is always how MLB negotiates(22:30) Why MLB teams don't want to compete with each other(25:00) The value of creating histories with players(29:00) Hypocrisy in the international market(33:30) Raising the signing age of international players(38:00) The shadow development system in Latin America(42:00) This felt like a misstep PR wise(45:00) Everyone loves the pick trading idea(50:50) Steroids and age issues in the international market(55:00) The pulse of international agents on the idea of a draft—Do you have feedback for the show or want to ask us a  question? Email us: futureprojection@baseballamerica.com.Future Projection Twitter: @FutureProPodBen's Twitter: @BenBadlerCarlos's Twitter: @CarlosACollazoBaseball America Website—SEAT GEEKUse our code for 10% off your next order of MLB tickets on SeatGeek*: seatgeek.onelink.me/RrnK/TERRITORY10 Sponsored by SeatGeek. *Restrictions apply. Max $20 discountAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

In this episode, Dr. Jockers shares a personal story about a medication he used in his teenage years and early 20s that he believes contributed to liver stress and significant gut disruption, setting the stage for a broader discussion on how common prescriptions can impact long-term health . He also breaks down why so many people are still using similar medications without realizing their potential downstream effects. You'll learn how the gut and liver work together to regulate inflammation, digestion, and detoxification, and why disrupting this relationship can show up as fatigue, digestive issues, nutrient deficiencies, and chronic symptoms. The episode also unpacks how some medications may temporarily reduce symptoms while quietly interfering with core biological systems like the microbiome and stomach acid production. We also explore five widely used medication categories—NSAIDs, antibiotics, acid blockers, birth control, and steroids—and how each one can influence gut integrity, immune balance, and metabolic health over time. By the end, you'll have a clearer perspective on when medication may be necessary and when it might be worth looking deeper at root-cause drivers instead. In This Episode:  00:00 PPI Mortality Warning 00:16 Podcast Intro and Coaching 02:35 Sponsor Ashwagandha Ad 04:53 Why Meds Miss Root Cause 08:01 NSAIDs Gut Damage 09:53 Antibiotics Overuse Risks 11:40 Apple Cider Vinegar Ad 13:52 PPIs and Acid Reflux Fixes 17:19 Birth Control Nutrient Drain 18:00 Steroids and Leaky Gut 19:01 Wrap Up and Next Steps Struggling with bloating, cravings, or blood sugar swings often comes down to poor digestive and metabolic support. This Apple Cider Vinegar Complex delivers the benefits of ACV without the harsh taste, plus added turmeric, ginger, Ceylon cinnamon, and lemon for enhanced gut and energy support. Go to paleovalley.com/jockers and save 15% off today   Boost your resilience and combat stress with Purality Health's premium Ashwagandha formula. This powerful adaptogen helps restore balance, improve energy, and reduce anxiety, all while supporting your overall wellness. Purality Health's unique Mycel Liposomal technology ensures maximum absorption for fast and effective results. Don't just take our word for it—try it risk-free for six months and experience the benefits for yourself! Visit renewyourhair.com/drj to claim your exclusive offer and start feeling your best today.   "Medications, most of the time, never address the root cause. They're only addressing symptoms in the body." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit paleovalley.com/jockers and save 15% off today Visit renewyourhair.com/drj to claim your exclusive offer Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

On this episode of What Are Your Thoughts, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Downtown Josh Brown⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Michael Batnick⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ are back to discuss: why Wall Street's earnings forecasts may be entering a "steroid era," the broadening bull market rally beyond mega-cap tech, whether Strategy's massive Bitcoin bet has become a systemic risk, growing signs of excessive speculation across leveraged markets, and why some software stocks could emerge as AI winners and not just casualties. Plus, Josh makes the case for Toast, Michael brings another mystery chart, and special appearance by Spencer Jakab of the WSJ! This episode is sponsored by DBM⁠⁠⁠F. To learn more about the Alts solution for the model revolution check out: ⁠www.DBMF.com/WAYT ⁠ Sign up for ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Compound Newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and never miss out! Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://instagram.com/thecompoundnews⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/thecompoundnews⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/company/the-compound-media/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@thecompoundnews⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Investing involves the risk of loss. This podcast is for informational purposes only and should not be or regarded as personalized investment advice or relied upon for investment decisions. Michael Batnick and Josh Brown are employees of Ritholtz Wealth Management and may maintain positions in the securities discussed in this video. All opinions expressed by them are solely their own opinion and do not reflect the opinion of Ritholtz Wealth Management. The Compound Media, Incorporated, an affiliate of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ritholtz Wealth Management⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, receives payment from various entities for advertisements in affiliated podcasts, blogs and emails. Inclusion of such advertisements does not constitute or imply endorsement, sponsorship or recommendation thereof, or any affiliation therewith, by the Content Creator or by Ritholtz Wealth Management or any of its employees. For additional advertisement disclaimers see here ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://ritholtzwealth.com/advertising-disclaimers⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Investments in securities involve the risk of loss. Any mention of a particular security and related performance data is not a recommendation to buy or sell that security. The information provided on this website (including any information that may be accessed through this website) is not directed at any investor or category of investors and is provided solely as general information. Obviously nothing on this channel should be considered as personalized financial advice or a solicitation to buy or sell any securities. See our disclosures here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://ritholtzwealth.com/podcast-youtube-disclosures/⁠⁠⁠⁠ DBMF Disclosure: The Fund's investment objectives, risks, charges, and expenses must be considered carefully before investing. The statutory and summary prospectuses contain this and other important information about the investment company, it may be obtained by visiting ⁠www.imgp.com⁠.  The iMGP DBi Managed Futures Strategy ETF is distributed by ALPS Distributors, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dan, Manny, & Billy put the American Gladiators franchise to the ultimate test—THE NOSTALGIA TEST!   “It'd be a lot more American if they walked in the ring and just shot each other.” -Billy D'Elia   While this episode was being recorded, the orange lunatic who's technically our “president” was building a UFC octagon on the front lawn of The White House, which was ultimately a disaster (F Joe Rogan). We all should've seen the free-fall of America coming in the late 80s when we were all watching American Gladiators on TV. This episode attempts to figure out what this show is, why were people into it, and why was it resurrected, twice! That's right, there is currently a new version with two seasons hosted by The Miz. Oh, and the first season of the 2026 version WAS FILMED IN FRANCE!? Now, all credit goes to each and every gladiator that was on this show because in 1989 they were treated like trash. Safety wasn't a thing, people were being knocked out, and gladiators were being forced to compete injured. Watching the “evolution” of American Gladiators is so interesting, because as the series continued the only thing that got updated were the games and the arena. They made it bigger and got rid of the cardboard cutout audience members. That's right! They did that. At the same time, the gladiators remained overworked, injured, and forced to literally fight people like they were circus animals in an underground fight club. This episode travels along a zig-zag path to get the controversial conclusion of the 2026 episode they watched, how The Miz is just screaming in people's faces, some of the best knockouts, faceplants, and announcer quotes, all the way to the guys talking about how they need a 100% win for an episode because this is killing their souls. So, grab your American flag bandanas, an oversized tank top, scream at the top of your lungs for no reason, and kick your best friend in the face, because it's time to talk American Gladiators! ***   If you love what we're doing and want to support the podcast so we can keep this show going with better equipment and maybe meet up with each other to do some in-person recording, sponsor to The Nostalgia Test: buymeacoffee.com/nostalgiatest   Lastly, we're looking to be booked for podcast appearances, hosting gigs and parties, maybe you have a block party coming up, a BBQ that you want to be Nostalgia themed and you're looking to make it seriously memorable, a reunion, etc., contact us to book the podcast. We're ready to Get Nostalgic With You:  Contact For Booking   *** Email us (thenostalgiatest@gmail.com) your thoughts, opinions, and topics for our next Nostalgia Test! Suggest A Test & Be Our Guest! We're always looking for a fun new topic for The Nostalgia Test. Hit the link above, tell us what you'd like to see tested, and be our guest for that episode! *** Approximate Rundown 00:00 American Gladiators Setup 01:16 Show Format Challenge 02:18 Main Era Gladiators 03:20 Reboots & Hosts 05:34 Saturday TV Memories 07:44 Early Seasons Chaos 08:47 Games Evolve Over Time 10:17 Joust & Judge Bits 11:18 Reality TV Before Reality 13:12 Behind the Scenes Grind 14:48 Brutal Interviews &Trauma 17:33 Downfall & Exploitation 19:11 Injuries & Rule Nonsense 24:09 America Culture Context 25:38 Does It Pass Nostalgia 26:51 Competition Show Landscape 32:07 Steroids & Wild Stories 35:41 Trash TV Reboot Setup 36:50 Peak Games And 1996 40:10 Rewatch Reality Check 40:25 Hogan Ali Reboot 41:47 Schlock Backstories 43:00 Bad Names Bad Vibes 44:12 Water Hazards 50:32 Why It Failed 51:54 Miz Era Rant 54:45 Finale Disqualification 57:35 Filmed in France 01:06:06 Fixing the Format 01:11:22 Nostalgia Verdict 01:15:26 Next Episode Pick 01:17:10 Major League Storytime 01:19:25 Wrap Up & Plugs   Book The Nostalgia Test Podcast Bring The Nostalgia Test Podcast's high energy fun and comedy on your podcast, to host your themed parties & special events!  The Nostalgia Test Podcast will create an unforgettable Nostalgic experience for any occasion because we are the party! We bring it 100% of the time! Email us at thenostalgiatest@gmail.com or fill out the form at this link. LET'S GET NOSTALGIC!       Keep up with all things The Nostalgia Test Podcast on Instagram | Substack | Discord | TikTok | Bluesky | YouTube | Facebook   The intro and outro music ('Neon Attack 80s') is by Emanmusic.

Cette semaine, nos invités ont des allures familières ! Et pour cause, puisqu'il s'agit de Julien Dupuy (non, ce n'est pas un homonyme) et Jeremy Fauchoux, les réalisateurs du documentaire CAROLCO : UN RÊVE HOLLYWOODIEN, actuellement disponible sur MyCanal et en Blu-Ray chez L'atelier d'images. Retraçant l'ascension fulgurante d'Andy Vajna et Mario Kassar, le documentaire relate comment les deux producteurs ont eu le tout Hollywood dans leurs pognes, le temps de faire quelques classiques comme TOTAL RECALL et TERMINATOR 2 : LE JUGEMENT DERNIER. Il fallait donc en parler dans un épisode de STEROIDS - LE PODCAST.Retrouvez toutes nos émissions sur http://www.capturemag.frPour nous soutenir, il y a deux adresses :PATREON : https://www.patreon.com/capturemagTIPEEE : https://www.tipeee.com/capture-magLISEZ CAPTURE MAG !Toutes nos revues sont disponibles dans les librairies, les magasins de produits culturels et sites marchands.Akileos : https://bit.ly/AkilsCMCapture Mag est sur LETTERBOXD : https://letterboxd.com/CaptureMag/#carolco #sylvesterstallone #arnoldschwarzenegger Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Tell us what you like or dislike about this episode!! Be honest, we don't bite!He has a £10M net worth, face tattoos, and absolutely nothing to sell you - and that alone should tell you this conversation is going to be different. In this episode, Matt Haycox sits down with Daniel Pekic - Australian expat, Bitcoin holder since under $1k, and one of the most genuinely unbucketable people on the internet. They get into how Daniel actually built his wealth (hint: it starts on the dark web), why he considers $10M unimpressive by Dubai standards, and the one trait he believes the TikTok generation has completely lost.Daniel doesn't hold back on the bigger picture either: the nanny state laws he happily breaks and why, his take on Western decline and whether it gets better before it gets worse, immigration, multiple passports, and what it really means to live as a sovereign individual. If you're tired of podcasts where someone's quietly selling you something, this is the antidote.Chapters0:00 - Coming Up0:14 - Intro1:40 - Who Is Daniel Pekic?6:18 - The Cost of Impatience15:02 - Building a Tattoo Empire in Bali17:55 - Managing Artists & Running a Profitable Shop23:51 - Why Business Partnerships Fail29:50 - How He Actually Discovered Bitcoin31:26 - The Moment Bitcoin Clicked35:58 - Bitcoin vs Altcoins & Crypto Sovereignty43:09 - Steroids, TRT & Performance51:39 - Breaking Laws & Where to Draw the Line56:46 - Is the West in Managed Decline?1:01:32 - Immigration & What Daniel Actually Means1:07:47 - Where He'd Actually Choose to Live1:13:19 - Multiple Passports & Flag Theory1:16:47 - The Face Tattoos: Regret or No Regret?1:20:51 - What's Next for DanielFollow Daniel:Youtube: https://www.youtube.com/@AskPekicInstagram: https://www.instagram.com/danielpekic/Website: https://askpekic.com/ 

Think about the last time you had to time something perfectly. Maybe it taking that perfect swing at the baseball, or catching a flight after a commute, or making a high-stakes decision. In the world of high-risk pregnancy, clinicians play a constant game of high-stakes timing with a usual medication called antenatal corticosteroids. Given to moms at risk of giving birth early, these steroids are a gamechanger for a preterm neonate. But there's a catch. If you give them too early, the benefits fade. If you give them too late and she delivers very quickly, they don't have time to work. A brand-new study published in the journal Obstetrics & Gynecology by Mark Clapp et al reveals just how incredibly difficult this balancing act is. This data shows that nearly 26% of pregnant individuals who received these steroids actually went on to deliver completely full-term, exposing babies to medications they might not have needed. So how do we as clinicians solve this OB Goldilocks problem where the stakes are a newborn baby's health? On today's episode, we break down the data behind 'maximizing benefit while avoiding overuse' and what it means for real world practice.Strong Coffee Company - Protein Coffee PLUS MORE; Get 20% OFF | Promo Code: CHAPANOSPINOBG https://promocode.to/strong-coffee-company/chapanospinobg-hbv1. Clapp, Mark A. MD, MPH; Li, Siguo MS; Melamed, Alexander MD, MPH; Reiff, Emily MD; Gyamfi-Bannerman, Cynthia MD, MS; Kaimal, Anjali J. MD, MAS. Maximizing Benefit From Antenatal Steroid Use While Avoiding Overuse. Obstetrics & Gynecology 148(1):p e33-e42, July 20262. FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm. Int J Gynaecol Obstet. 2021 Oct;155(1):26-303. Society for Maternal-Fetal Medicine Special Statement: Quality metrics for optimal timing of antenatal corticosteroid administration; 2022

6/22/2026 PODCAST Episodes #2397 - #2399 GUESTS: Nicolas Hulscher, Rob Schilling, Rep. Derrick Van Orden + YOUR CALLS! at 1-888-480-JOHN (5646) and GETTR Live! @jfradioshow #GodzillaOfTruth #TruckingTheTruth   Want more of today's show? Episode #2397 Fake News On Lying Steroids over Iran Deal Episode #2398 The New Tokyo Rose Episode #2399 America Speaks!   https://johnfredericksradio.libsyn.com/

Episode 2816 - Vinnie Tortorich speaks with Dr. Zoe Harcombe about the myth of "settled science" and a new drug that is basically a "statin on steroids." https://vinnietortorich.com/2026/06/statin-on-steroids-episode-2816 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout A Statin on Steroids The resurgence of the Rice Diet. 6:00 The facts behind the scenes of that study/diet. It is also devoid of any real nutrients. Denise Minger took apart The China Study. The myth of low-carb and the misguided dietary guidelines. (21:00) Efforts to modify the guidelines to correct them have faced backlash. Fat has been incorrectly demonized. Confirmation bias is a real issue that hinders the search for the truth. (27:00) In 2019, Dr. Harcombe and her colleague initiated a defamation lawsuit after an article about them accused them of misinformation. (34:00) Extreme viewpoints on diet and health are not helpful. (42:00) What is Dr. Harcombe's opinion on the new statin Repatha (Evolocumab)? (52:00) Cholesterol is too important in the body, and forcing it too low could be risky. You can find Dr. Harcombe at https://www.zoeharcombe.com/ ALSO: Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section to purchase them there, too. (58:30) https://purevitaminclub.com/collections/food-and-snacks The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

In this episode of the Lupus Foundation of America's The Expert Series podcast, we focus on how steroids are an essential and often life-saving treatment for people with lupus, even though the new SLE guidelines recommend using them as little as possible. Our guest speaker, Dr. Megan Lockwood, walks us through why steroids play such a critical role in lupus care, the potential risks and downsides of prolonged use and why limiting their use whenever possible is equally important. We also discuss how patients can work with their health care providers to develop a thoughtful, personalized steroid plan and have productive conversations with their doctors about managing steroid treatment.Sign up to receive emails from the Lupus Foundation of America (LFA) when new episodes are published: https://support.lupus.org/site/SPageNavigator/email_subscribe_expert_series.htmlThis episode will help you understand:How steroid mechanism of actionThe importance of minimizing steroid useShort and long-term side effects of steroidsAlternatives to steroids in lupus treatmentSafe steroid tapering strategiesFuture treatments and research developmentsRelated Resources:Ask a Lupus Health Educator (LFA): https://www.lupus.org/care-support/ask-a-health-educatorFind Support Near You (LFA): https://www.lupus.org/resources/find-support-near-youNational Resource Center on Lupus (LFA): https://www.lupus.org/resourcesThe Expert Series (LFA): https://www.lupus.org/resources/lupus-the-expert-seriesMedications Used to Treat Lupus (LFA): https://www.lupus.org/resources/medications-used-to-treat-lupus

Welcome to Episode 148 of ShiftLess! Coming at you straight from the mobile van studio, Kevin and Chef Brad dive deep into the gear trends dominating this year's Tour Divide. From the undeniable takeover of rear racks (shoutout Tailfin) over traditional saddlebags to the absolute dominance of Vittoria Mezcals, we are breaking down what the ultra-endurance crowd is actually running.We also get into the weeds on Scott's flat-bar Scale RC—is a 20lb rigid mountain bike really a "gravel" bike?—the disruptive arrival of X-Labs and XDS in the carbon market, and why we are still waiting for that 32-inch wheel revolution to finally hit the dirt.Then, things get real as we tackle the elephant in the peloton: performance-enhancing drugs. Are massive "carbs per hour" claims and extreme ketone use just a convenient mask for a new era of undetectable PEDs? We compare modern cycling's explosive power numbers to the Lance Armstrong and Mark McGwire eras of sports.Plus, an exciting USA Trail update as the Florida segment is officially done and dusted, some pop-culture nostalgia, and Chef Brad walks us through his insane 9-course summer pop-up dinner menu.Tour Divide Gear Check: The massive shift from saddlebags to rear racks, Garmin vs. Coros Dura, and the missing 32-inch test bikes.Industry Shakeups: Scott's Scale Gravel RC blurring the MTB lines and how XDS might completely disrupt carbon bike pricing.The PED Conspiracy: A candid discussion on TRT, ketones, and whether the pro peloton is quietly slipping back into its old ways.USA Trail Update: Florida scouting is completely verified and finished.Off The Bars: Hawk attacks in the yard, 25 years of The Fast and the Furious, and Chef Brad's 95-degree friendly 9-course culinary masterclass.Tags/Keywords:Tour Divide 2024, Bikepacking Gear, Tailfin Rack, Gravel Cycling, Scott Scale Gravel RC, XDS Bikes, PEDs in Cycling, Pro Peloton Doping, USA Trail Route, Basepacking, ShiftLess PodcastIn This Episode:Shiftless Ep. 148: Tour Divide Preview, Gear Trends, 32-inch Wheels, and Doping TalkIn Shiftless episode 148, the hosts preview the Tour Divide and discuss last year's fastest time by Robin (11 days, 19 hours, 14 minutes) being ineligible due to reroutes, then review Bikepacking.com's rig data: no 32-inch bikes in the field, rear racks now dominate (about 77%) led by Tailfin, flat bars slightly outnumber drop bars, Salsa remains the biggest brand (mostly Cutthroats) though with reduced share, Mezcal tires are most common, and electronic drivetrains and Coros Dura computers are more prevalent. They debate Scott's marketing around 32-inch prototypes and a rigid flat-bar “Scott Scale Gravel RC” listed as a gravel bike, and reflect on generational gaps and monoculture. 00:00 Tour Divide Preview Kickoff00:28 Record Pace Reality Check01:20 Gear Teasers And Hot Takes03:39 Reroutes And Last Year Recap04:52 Surprise Visitor Interruption06:47 Back To Divide Gear Trends09:04 Racks Droppers And Old School12:43 Brands Tires And Bike Computers19:16 No 32s And Scott Marketing23:08 Scott Scale Gravel Confusion24:33 Generational Gap And Monoculture31:08 Cycling's Missing Youth32:21 Marketing to New Riders33:53 Scott Bike Lineup Hunt34:58 Steroids and Spectacle37:49 Is That Really Gravel40:59 Doping Returns Debate51:52 Fast and Furious Detour54:15 Better Call Saul Talk58:50 Backyard Hawks and Snakes01:00:35 USA Trail and Industry News01:04:46 Will Prices Backtrack01:05:21 China Subsidy Advantage01:06:05 Carbon Rims and Rebrands01:08:07 China vs Taiwan Fact Check01:09:39 XDS Scale and Market Reality01:11:14 E-Bike Market Direction01:13:58 Tour de France and Side Tangents01:16:47 Wildlife Yard Interlude01:19:15 Pop-Up Dinner Menu Breakdown01:23:15 Rides Weather and Moto Luggage01:26:02 Tour Hype and Doping Debate01:34:45 Where Supplements Become Doping01:38:25 Lance Era Doubt and Wrap-Up

Today we have another Pulm PEEPs Pearls episode about a core critical care topic. Furf and Monty will be giving a high level overview of the use of steroids in sepsis including a review of the relevant literature and recent guidelines, and pragmatic bedside points. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points Why Steroids in Sepsis? Steroids do not treat the infection — antimicrobials are always first and remain the cornerstone. The goal is addressing critical illness–related corticosteroid insufficiency (CIRCI), where cortisol production cannot keep up with the overwhelming inflammatory demand of septic shock. Hydrocortisone helps in two main ways: Blunts the dysregulated inflammatory response — tempers the excessive vasodilation and febrile response that drive harm beyond the infection itself. Restores vascular sensitivity to catecholamines — sepsis downregulates adrenergic receptors; steroids turn that responsiveness back on. Clinical takeaway: The first thing you notice is vasopressor weaning (or a bend in the escalation curve) — not a rapid improvement in fever or white count. Caveat: These trials predate modern sepsis phenotyping. None distinguish hyperinflammatory vs. hypoinflammatory responders — they treat all comers. The Evidence: Four Landmark Trials Every IM resident and critical care fellow will eventually journal-club these four. The most consistent signal across all of them is faster shock reversal and reduced vasopressor use; the mortality question remains unsettled. Trial (Year)NRegimenKey FindingAnnane (2002)~300Hydrocortisone + fludrocortisoneMortality benefit in ACTH non-responders; criticized methodology and messy cortisol-response testing; not cleanly replicated.CORTICUS (2008)~500Hydrocortisone aloneFaster shock reversal but no mortality benefit, regardless of cortisol responsiveness. Raised (later allayed) superinfection concern. Cornerstone for abandoning routine cort-stim testing.ADRENAL (2018)~3,800Hydrocortisone aloneFaster vasopressor weaning; no 90-day mortality benefit.APROCCHSS (2018)~1,200Hydrocortisone + fludrocortisoneMortality benefit at 90 days. Bottom line: Faster shock reversal is consistent. Mortality benefit appears in 2 of 4 trials (both used fludrocortisone) but not the others. A 2026 meta-analysis showed benefit for hydrocortisone + fludrocortisone vs. placebo, but not for hydrocortisone + fludrocortisone vs. hydrocortisone alone — suggesting hydrocortisone drives the main effect. Who Gets Steroids, and When? 2021 Surviving Sepsis: Consider steroids for norepinephrine or epinephrine ≥ 0.25 mcg/kg/min for ≥ 4 hours despite adequate resuscitation — a reasonable bedside trigger. Early 2026 update: Moved away from a specific numeric trigger — consider steroids when a septic patient is not responding well to vasopressors or has escalating requirements. Make a clinical decision. (Quality of evidence: low to moderate.) Go faster than the threshold when: Known/suspected adrenal insufficiency or home steroids, or florid pressor-requiring shock on arrival. A practical escalation sequence: escalating norepinephrine → add vasopressin (per VASST) → then add steroids if requirements keep climbing. Do NOT wait for an ACTH stimulation test. It does not reliably predict who responds and only delays treatment. Sepsis is an elevated-cortisol state but can dissociate ACTH and cortisol, and cortisol-binding globulin is depleted — the test is too messy to guide care. What to Give: The Regimen Standard dose: Hydrocortisone 200 mg/day, typically 50 mg IV Q6H. (Original trials often used continuous infusions, rarely used in the U.S.) Some start with a 100 mg bolus to gain control. Higher dose: If chronically on steroids / adrenally insufficient, consider ~300 mg/day (e.g., 100 mg Q8H). Fludrocortisone: Unsettled. The two mortality-benefit trials added it (50 mcg PO/NG/OG daily), but hydrocortisone already has mineralocorticoid activity and meta-analyses don't show added benefit over hydrocortisone alone. Most clinicians omit it — adding it is reasonable and safe, just be honest about the uncertainty. Duration & Tapering Typical course: ~7 days is most common. Trial practices varied (ADRENAL ~7 days; VANISH used a taper after 6 days; some continue until pressors are off). No taper needed. You do not need to taper for adrenal insufficiency after a short course — just stop. If pressors dramatically rebound, you can restart, but most patients have gained the benefit they'll get by day 7. Pitfalls & Safety Hyperglycemia: Expected and must be managed (monitor closely; insulin drip if needed). No signal for major DKA / severe complications in the trials. Superinfection / fungal infection: The most-quoted concern, but the overall literature does not show a convincing, statistically significant increase. Be disciplined about stopping on schedule. Muscle weakness: Steroids can worsen critical illness myopathy; a short 7-day course likely has limited effect, but be aware. Other: GI bleeding (follow general PPI prophylaxis guidance) and sodium disturbances (watch for hyper-/hyponatremia). Two things we know: (1) steroids shorten duration of vasopressor support, and (2) they are relatively safe in sepsis. Whether they improve mortality — and in whom — remains open. The Five Pulm PEEPs Pearls Mechanism: Steroids restore catecholamine vascular sensitivity and blunt dysregulated inflammation. The clinical target is vasopressor weaning, not infection treatment. Evidence: Faster shock reversal is the most consistent finding. Mortality benefit is seen in 2 of 4 trials but not the others — still controversial. Some patients likely benefit; we don't yet know who. Trigger: A practical 2021 threshold is levo/epi ≥ 0.25 mcg/kg/min for ≥ 4 hours. Newer guidance drops the strict number — make a clinical decision based on poor pressor response or escalation. Dose: Hydrocortisone 200 mg/day (e.g., 50 mg Q6H). Adding fludrocortisone mirrors two trials, but meta-analyses find no benefit over hydrocortisone alone. Safety: Steroids appear safe in sepsis. Monitor and treat hyperglycemia; no marked increase in superinfection. References and Further Reading Annane, Djillali et al. “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.” JAMA vol. 288,7 (2002): 862-71. doi:10.1001/jama.288.7.862 Sprung, Charles L et al. “Hydrocortisone therapy for patients with septic shock.” The New England journal of medicine vol. 358,2 (2008): 111-24. doi:10.1056/NEJMoa071366 Venkatesh, Balasubramanian et al. “Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 797-808. doi:10.1056/NEJMoa1705835 Annane, Djillali et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 809-818. doi:10.1056/NEJMoa1705716 Sun, Alin et al. “Correction: Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.” Frontiers in medicine vol. 13 1811616. 2 Mar. 2026, doi:10.3389/fmed.2026.1811616 Prescott, Hallie C et al. “Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.” Critical care medicine vol. 54,4 (2026): 715-724. doi:10.1097/CCM.0000000000007089

The underground steroid market is changing fast. We break down new developments in China API production, Operation Pangea, law enforcement focus on online sales, and what it could mean for PED users moving forward. Plus, we answer your listener questions on estrogen management, Anavar use, TRT+, growth hormone dosing, Masteron, AFIB, stubborn fat loss, and much more. Hosted by Dave Crosland and Scott McNally 0:00 Welcome Back to Drugs n Stuff 0:45 Testosterone Production Industry Update 3:00 China API Production Changes Explained 8:45 Operation Pangea Disrupting the Steroid Market 11:25 Law Enforcement Targets Online Steroid Sales 14:45 Is the U.S. Still Investigating? 17:20 Support Our Sponsor - True Nutrition 18:00 How Important Is Keeping Estrogen In Range? 23:10 Can You Use PEDs If You Have AFIB? 25:15 Can You Build Muscle With Resistance Bands? 28:15 Are People Overusing Lab Work? 31:45 Anavar Only On Training Days? 34:20 First Steroid Cycle vs TRT Plus 36:15 Getting Rid Of Lower Abdominal Fat 39:00 The Worst Cycle We've Ever Heard 43:30 YK-11 Real World Listener Feedback 45:00 2 IU vs 10 IU Growth Hormone 48:45 Using Gear After Massive Fat Loss 51:30 High Masteron Cycles And Aging Skin 53:45 Can Steroids Cause Carpal Tunnel? 55:15 Cialis For Pumps And Contest Prep 57:00 Crack On! 57:30 Dave's Story Of Being A Fugitive UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

Big Sexy Sean McCorkle Part 2 - UFC Exit, Monte Cox, Steroids, Wild Post-UFC Fights & More | Episode 333Big Sexy Sean McCorkle returns for an even more unfiltered Part 2. Shawn opens up about his controversial UFC departure after Joe Silva's warnings about his tweets, the “risk vs reward” conversation, and his raw farewell message. He dives deep into his relationship with manager Monty Cox, handshake deals, pay-per-view points battles, and behind-the-scenes UFC politics with Dana White, the Fertittas, and discretionary bonuses.Sean shares hilarious and chaotic post-UFC stories: the legendary Mike Hayes fight hype prank that hit Yahoo Sports, last-minute opponent negotiations, cutting to 285 on Winstrol/Anavar, the Cameron Befort (not Vitor Belfort) finish, and a wild post-fight “Fidel Castro / Free Cuba” shoutout in Miami. He also discusses steroid cycles, weight cuts, near-misses with Jason Guida, Bellator dealings, and memorable run-ins with Travis Brown, Matt Mitrione, Brendan Schaub, and more.Plus: the WWE offer, pro wrestling stories, family life, his son's comedy ambitions, and why he has zero regrets living life on his own terms.Drop your questions for Part 3 in the comments — we're bringing Big Sexy back!Subscribe for more early UFC, EliteXC, Cage Rage, and regional MMA history deep dives.The MMA History Podcast preserves raw, untold stories from the pioneers who built the sport.0:00 start0:43 MMA history podcast intro 1:15 Joey Venti's guest introduction1:31 interview start 2:00 getting recognized internationally4:27 departing from the UFC7:41 UFC becoming anti free speech 10:54 dealings with Monte Cox 14:42 thoughts on Dana White 15:55 UFC not paying fighters for public appearances19:45 looking for fights after UFC release20:52 issues with Sam Hoger 22:14 hyping up fight with Mike Hayes “ canceled bout” 32:41 offered fight with Tony Lopez 33:31 negotiating fight with Cameron Befort 39:37 Sean McCorkle vs Cameron Befort 39:47 controversial post fight interview41:58 understanding fight capabilities 45:10 bad experience with the Schmo46:29 travis Brown story52:32 Sean McCorkle vs Alex Rozman54:03 turning down Hollywood producers56:22 getting an offer from the WWE 57:35 meeting professional wrestlers at signings1:00:56 talking to Alex Rozman after fight 1:04:05 sending Alex Rozman money for commissary1:07:06 UFC refusing to let Sean McCorkle return 1:08:42 the Fertitta brothers ties to the Mob1:10:15 Sean McCorkle vs Justin Grizzard1:12:34 interactions with Alex Trujillo 1:14:12 Sean McCorkle vs Richard White 1:16:01 Pat Curran vs Joe Warren “bad stoppage” 1:19:29 Sean McCorkle vs Christian Morecraft 1:21:51 Joe Silva refusing to book local fighters1:23:57 receiving front row tickets from Dana White 1:28:14 next chapter of fight career 1:29:38 Sean McCorkle's son pursuing comedy 1:31:11 roasting Brandon Schaub online 1:36:36 issues with hosting a podcast 1:39:03 having unbelievable stories1:43:03 interview wrap up  1:43:13 outro/ closing thoughts#MMAHistoryPodcast #UFC #MMA #MontyCox #JoeSilva #UFCFighters #SteroidsInMMA #FighterStories #CombatSports

Short steroid cycles, contest prep decisions, max testosterone dosing, training, recovery and real-world bodybuilding coaching. Coaches Skip Hill, Andrew Berry and Scott McNally answer listener questions on cycle length, muscle growth, shift work, fat loss, training performance and the practical decisions that shape better physiques. 0:00 4-Week Cycle Results (Preview) 0:30 Support Our Sponsors 1:00 Shortest Effective Steroid Cycles 1:45 What Is A Normal Cycle Length? 3:55 Coming Off Testosterone Between Cycles 4:25 Are 10-Week Cycles Long Enough? 6:15 Do 6-Week Cycles Work? 7:30 Is There A Benefit To 4-Week Cycles? 9:45 The Mindset Shift Of Short Cycles 15:50 Using Long Esters In Short Cycles 18:50 Best Training Split For Shift Workers 23:00 Bodybuilding On A Swing Shift Schedule 31:00 Managing Sleep Around Work & Training 35:24 How Old Can You Still Build Muscle? 47:00 Contest Prep: Fullness vs Fat Loss 49:00 Maintaining Strength While Dieting 53:30 One Compound We Don't Recommend Like We Used To 56:45 Maximum Testosterone Before It Hurts Your Look 1:00:30 Best Ab Exercises For Bodybuilders 1:02:20 Does Skip Still Ride Motorcycles? 1:06:18 Why National-Level Bodybuilding Is So Competitive

It's friday and it's time to get caught on on the stories that matter.  This week we are covering Shotzi winning a title, Vince avoiding a trail, WWE shutting off the power and more.  Cheers! Buy a fucking shirt: https://whatamaneuver.net/search?q=drunk+wrestling+history Subscribe to our YouTube Channel: https://www.youtube.com/channel/UCGDuaXlrj8A_Ur6nBZX0fVg/featured Follow us @wrestling_drunk on Twitter, Instagram, and TikTok Follow Adam @SaveUsBobMan Don't follow Scott @feedmetacobell Make sure to subscribe, rate, and review. Buy a fucking shirt: https://whatamaneuver.net/search?q=drunk+wrestling+history Subscribe to our YouTube Channel: https://www.youtube.com/channel/UCGDuaXlrj8A_Ur6nBZX0fVg/featured Follow us @wrestling_drunk on Twitter, Instagram, and TikTok Follow Adam @SaveUsBobMan Don't follow Scott @feedmetacobell Make sure to subscribe, rate, and review.

Learn how to enhance your physique with expert insights on bodybuilding and nutrition. Discover key strategies that work for both natural and enhanced athletes. In the world of fitness and bodybuilding, there's a wealth of information, but sifting through it all can be overwhelming. Whether you're just starting out or looking to refine your approach, understanding how to effectively optimize your physique is crucial. In this post, we'll explore key insights from Paul Barnett, an IFBB pro bodybuilder and retired tech CEO, who delves into the science of bodybuilding and biohacking to maximize resultsRelevant links:Visit Paul Barnett's Website: https://www.anabolicbodybuilding.com/Disclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

En attendant que SALE TEMPS POUR UN FILM prenne le relais pour parler de DISCLOSURE DAY, l'autre actualité musclée de la semaine, c'est THE FURIOUS de Kenji Tanigaki. Soyons honnêtes : déjà considéré comme « le plus grand film d'action de tous les temps » de la semaine, ce long-métrage bien bourrin n'atteint peut-être pas les cimes promises. Mais il y a à boire et à manger dans THE FURIOUS, et Yannick Dahan et Stéphane Moïssakis sont sur le coup… s'ils arrivent à démarrer l'émission sans s'étouffer de rire !Retrouvez toutes nos émissions sur http://www.capturemag.frPour nous soutenir, il y a deux adresses :PATREON : https://www.patreon.com/capturemagTIPEEE : https://www.tipeee.com/capture-magLISEZ CAPTURE MAG !Toutes nos revues sont disponibles dans les librairies, les magasins de produits culturels et sites marchands.Akileos : https://bit.ly/AkilsCMCapture Mag est sur LETTERBOXD : https://letterboxd.com/CaptureMag/#thefurious #actionmovies #martialarts Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode of Drugs N Stuff, we answer your steroid and PED questions covering TRT, Tren, Deca, NPP, gyno prevention, contest prep cycles, growth hormone, and more. We also discuss cycle design, nandrolone, androgen receptor sensitivity, and the practical decisions lifters face when planning their next phase. Plus, Dave shares another chapter of Dave the Fugitive and we answer a wide range of audience questions. 0:00 Support Our Sponsors 1:35 Growth Hormone Banned in China? What It Means 8:30 Are Steroids in Ampules Harder to Counterfeit? 19:30 How to Minimize Gynecomastia Risk 22:00 TRT vs Coming Off Cycle | Androgen Receptor Sensitivity 31:00 When to Add a Second Compound to Testosterone 34:20 Injectable YK-11 Feedback & Experiences 35:15 Low Dose Tren for a Summer Recomp 41:00 NPP vs Deca | Are They Equal Mg for Mg? 44:20 Managing a Bulk & Adding an Oral Compound 47:35 Can Nandrolone Improve Mood? 48:45 Favorite Classic Cars & Modern Cars 54:00 Low Dose Deca with Low Dose Tren 56:10 Standard Contest Prep Steroid Cycles 57:30 Steroid Advice for "Average Gym Bros" vs Competitors 1:02:30 Dave the Fugitive Part 4 UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

Most men think erectile dysfunction is a bedroom problem. It's actually one of the earliest warning signs of cardiovascular disease, capable of showing up three to five years before a heart attack.In this episode, Dr. Gabrielle Lyon sits down with Dr. Amy Pearlman, a urologist trained in men's sexual health, to discuss:Why ED is a symptom of vascular health, not a standalone disease and how the artery feeding the heart is roughly double the size of the one feeding the penis, so problems show up "down there" firstWhy "normal" testosterone can be meaningless, and the questions to ask before accepting a lab result that didn't flagHow daily erections preserve penile tissue the way water keeps a sponge supple and why disuse can cost noticeable size over just a few monthsThat cardiovascular exercise can rival ED medication for improving erectile function, making your heart health the real fixHow to track erectile fitness before there's a problem, instead of waiting until something breaksBy the end, you'll understand the single signal your body uses to flag heart and metabolic risk early and the simple, mostly drug-free steps that protect both your cardiovascular health and your sexual function for life.Thank you to our sponsors:Manukora - Go to https://bit.ly/3RCMrKx to save 31% plus $25 worth of free gifts.Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGNBon Charge - Save 15% at https://bit.ly/433Xi2B with code DRLYONExplore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Listen to "Pearls of Wisdom" on all your favorite platforms!Spotify: https://open.spotify.com/show/4uOhWn5DeVXO7D2ppa0RoVApple Podcasts: https://podcasts.apple.com/us/podcast/pearls-of-wisdom/id1617916659Find Dr. Amy Pearlman at:Website: https://www.primeinstitute.us/YouTube: https://youtube.com/@docamyurology?si=oJ2LZ_sxMPYTaK41Instagram: https://www.instagram.com/amypearlmanmd/X: https://x.com/AmyPearlman1LinkedIn: https://www.linkedin.com/in/amy-pearlman-54a2b0208Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonTimestamps00:00 - Introduction01:25 - Erections predict cardiac events01:41 - The pen and artery analogy03:40 - No health milestones for men07:52 - Normal structure and function11:45 - The five S's of men's health21:24 - Why "normal" testosterone misleads25:00 - Testosterone and fertility risk31:05 - Steroids versus FDA-approved agents41:13 - The untreated 25-year-old43:56 - Sperm health and home testing52:02 - Peyronie's disease and injury1:01:34 - Protein, nutrition, supplements1:05:09 - Daily Cialis as a pre-workout1:13:32 - The sponge analogy1:15:31 - Erectile fitness tracking1:23:05 - The penis pump, used right1:27:24 - Restoring lost size1:35:00 - Traction and girth enhancement1:46:00 - Women's anatomy and pleasureIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

He went from $180K for 14 units… to 7,500 multifamily units… to NOW closing 7 hotels in a single year with $40M of investor capital.   In this short clip from Abundance Mindset, Vinney "Smile" Chopra breaks down:

The Enhanced Games are kind of like the Olympics except everyone is on performance enhancing drugs. The organizers want to push back on the shame of doping. But they're also trying to sell you something. This episode was produced by Ariana Aspuru, edited by Jolie Myers, fact-checked by Gabriel Dunatov, engineered by David Tatasciore, and hosted by Noel King. Deadlifter Hafþór Júlíus Björnsson competes in the Enhanced Games in Las Vegas. Photo by Greg Doherty/Getty Images for Enhanced. Listen to Today, Explained ad-free by becoming a Vox Member: vox.com/members. New Vox members get $20 off their membership right now. Transcript at ⁠vox.com/today-explained-podcast.⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Reasonable Ignorance - The Podcast Show hosted by Jamal Shabazz (@kingboola) Magic Mike Walton (@magicmike32). Two Black Men raised on Chicago's Southside bringing you their views on today's Music, Business, and World Events.

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Coach O is BACK at LSU and somehow the SEC got even more unhinged. This week on Craft Brewed Sports:

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How long are bodybuilding cycles in 2026 — and how long is too long? Scott McNally and Dave break down modern cycle length, TRT, Proviron, Test No Ester, recovery, and real-world PED use. Plus Milos coaching Hadi, MK677 for appetite, gut health discussion, and Dave's fugitive story Part 2. 0:00 Support the show by shopping with our advertisers 2:00 WVE-007 RNA Therapy 4:20 6-Month Trial Results 7:45 Financial Fallout 12:30 Max Cycle Length 25:10 Is Proviron Worth It? 29:20 Test No Ester Preworkout 34:30 Shortest Effective Cycle 43:25 MK677 for Anadrol Appetite 44:40 TRT Test/Deca/Mast Ratio 48:55 Fixing Stomach Acid Issues 55:30 Milos Coaching Hadi 1:01:00 Dave Fugitive Story Pt. 2 1:18:10 Behind The Scenes UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

We still down this week and talk about Tom marrying his sister in law, softballs wins, and peptides! SPONSOR@pioneer_fitpioneerfit.comShow Hosts@tomkal1@huckfinnbarbell@Jacob.w.ross@hfbapparel@letsgetstupidpodcast@officialbebetterbrandletsgetstupidpodcast@gmail.comwww.huckfinnbarbell.comwww.bebetterofficial.com

May 19, 2026Department of Justice announces $1.776 billion “Anti-Weaponization Fund," Administration continues to blame others for actions that they themselves are doing, The fund is not part of a legal settlement of Trump's case against the IRS, which Trump has withdrawn, But Trump has reached an agreement with the DOJ, giving him full control of the fund, Trump loyalists are looking to compensate participants in the January 6 insurrection, The agreement was then amended to add a blanket promise to stop all IRS audits of Trump, his sons, and the Trump Organization, Described as a "pardon on steroids,” it appears intended to stop the government from convicting Trump of tax evasion, Meanwhile, Trump held a press conference to talk about the White House ballroom.Watch today's recording here: https://www.youtube.com/live/g9TUa1Rwd6U?si=T8_KKcHQZElhpnZ-Get full, free access to Letters from an American here: https://heathercoxrichardson.substack.com/subscribeYou can also find me:Bluesky: https://bsky.app/profile/hcrichardson.bsky.socialInstagram: https://www.instagram.com/heathercoxrichardson/?hl=enFacebook: https://www.facebook.com/heathercoxrichardson/YouTube: https://www.youtube.com/@heathercoxrichardson Get full access to Letters from an American at heathercoxrichardson.substack.com/subscribe

What if Olympic athletes could use steroids and other performance-enhancing drugs, legally? They can now, at the Enhanced Games. The Enhanced Games take place on May 24th and it’s anyone’s guess what will happen.Unless you’re Chris Gayomali, host of the new podcast SuperHuman, which is an inside look at the ‘steroid Olympics.’ Chris Gayomali joins Oz to break down how aging tanks athletes' earning potential, how the Enhanced Games strives to be like Formula One, and what drew big-money backers Peter Thiel and Donald Trump Jr. to the table. Additional Reading: SuperHuman | iHeart What Would the Olympics Be Like If the Athletes Could Juice? | GQ EXCLUSIVE NordVPN Deal ➼ https://nordvpn.com/techstuff Try it risk-free now with a 30-day money-back guaranteeSee omnystudio.com/listener for privacy information.