Podcasts about steroids

Please visit answersincme.com/860/240201375-replay to participate, download slides and supporting materials, complete the post test, and get a certificate. Presented by James Michael Ramsahai, BSc, MD, PhD, FRCPC and Nan Zhao, BSc, MD, FRCPC. In this activity, experts in managing severe eosinophilic asthma discuss evidence-based strategies for personalizing biologic therapy, reducing steroid burden, and optimizing treatment in the setting of overlapping eosinophilic diseases. Upon completion of this activity, participants should be better able to: Identify strategies to individualize the selection of biologic therapies for patients with severe eosinophilic asthma based on the latest clinical and real-world evidence; Evaluate the implications of real-world data on biologic therapies for addressing airway remodeling and airway plugging; Develop steroid-sparing treatment plans and monitoring strategies for patients with severe eosinophilic asthma; and Formulate treatment plans to adjust the use of biologic therapies in patients with severe eosinophilic asthma and overlapping eosinophilic comorbidities.

Topical steroid withdrawal syndrome is finally getting the serious attention it deserves. In this episode, talk about the first published criteria to help doctors diagnose TSW (also known as red skin syndrome) and why it will help validate the experience of people who have been dismissed, misdiagnosed, or told they simply have severe eczema. We also dig into the growing gap between patient experience and conventional dermatology, and why that disconnect has left so many people searching for answers on their own.Dr. Olivia Hsu Friedman, DACM, L.Ac, Dipl.OM, joins me to discuss this and more! She is the owner of Amethyst Holistic Skin Solutions and brings extensive training in acupuncture, Chinese medicine, and dermatology to this timely discussion.⭐️Mentioned in This Episode:- See all the references

Book a free consultation call with Robert Sikes on breaking through your Keto or low carb plateau here: https://www.ketobodybuilding.com/callMost bodybuilders are destroying their lives for a plastic trophy and don't even know it. This episode exposes the truth about building a physique that enhances your life instead of consuming it.In episode 866 of the Savage Perspective Podcast, host Robert Sikes sits down with natural bodybuilding legend Jeff Alberts to discuss the secrets to over 30 years of success in the sport. They reveal how to build a sustainable fitness lifestyle, explaining the right way to approach building and cutting phases without ruining your metabolism or your relationship with food. Jeff shares his personal journey with aging, training, and finding balance between family, fatherhood, and fitness. This is a must-watch for any man who wants to master his body and his life.Follow Jeff on IG: https://www.instagram.com/3dmj_godfather/Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQChapters0:00 - A Veteran Bodybuilder's Evolving Mindset on Competing4:07 - The Art of Longevity & Redefining "Your Best" As You Age7:45 - Beyond the Physique: Maturing as a Person and an Athlete13:03 - A Sustainable Approach to Building & Cutting Phases20:06 - The Psychological Trap of Extreme Dieting23:48 - TRT, Steroids, and the "Easy Button" in Modern Fitness30:32 - How to Evolve Your Training Without Chasing Fads35:27 - Navigating Polygraphs, Supplements, and Health Scares40:08 - The Dark Side of Social Media for Fitness Creators45:22 - The Unspoken Challenge of Intentionally Gaining Weight47:01 - The 3 Pillars of Bodybuilding Mastery: Science, Skill & Art50:53 - How to Create Authentic Content the Algorithm Ignores56:36 - Finding the Right Training Style for Long-Term Progress1:04:55 - Life Outside the Gym: What Truly Matters1:08:27 - Where to Find More from Jeff Alberts

Hello and welcome to series 10! It feels like quite an achievment for little old me. In this episode I wander after work in my fav woods, going slightly bonkers and talking about a few future events. Come along and join me...Lots more guests to come in series 10. Join me on Patreon for extra creativity from the podcasts. New posts each week.Let's Create - A Mentored Journey Into Landscape Photography⁠⁠⁠⁠⁠⁠⁠⁠➡️⁠ ⁠https://malidavies.co.uk/lets-create-landscape-photography-mentoring⁠Grab a copy of my zine CREATE available in print and digital download⁠⁠⁠⁠⁠⁠⁠➡️ https://malidavies.co.uk/shop⁠⁠⁠⁠⁠⁠⁠Do please consider supporting what I do so I can keep doing more... Join me on Patreon today.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠➡️ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Mali Davies Photography On Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book yourself a place on my workshops at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠➡️ ⁠⁠⁠⁠⁠⁠MaliDavies.co.uk⁠⁠⁠⁠Thank you to everyone for your kind words and support#Inbetween #letscreate #LetsTalk #Podcast Join me on social media and my website...⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠➡️ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Mali Photography Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠➡️ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Check out all my social media links and join me on various groups⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Feel free to drop me a message and have a chat.Thank you and SITHEE!S10 EP1 Lets Create The In Between - Daffodils on Steroids

Potentially the most outspoken man in the bodybuilding industry.APR Health Solutions: www.aprhealthsolutions.comOptimize HRT Clinic: https://members.optimize-hp.com - code 'NYLE'Merch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle00:00:00 Intro00:03:22 Catching Up with Phil Viz00:05:32 Advanced Follicle Bio-Hacking00:12:06 The Peptide Gut Protocol00:15:30 The Truth About Kratom00:17:55 Pushing Mitochondrial Limits00:20:14 Microdosing Insulin & GLP-1s00:23:45 Warning: The Motility Crisis00:28:41 Mechanical Gut Scraping00:33:02 Sourcing Laboratory Standards00:37:30 Mentorship & Origin Stories00:45:00 Execution Under Fire00:48:10 Victory Has Defeated You00:51:30 Psychological Pain as Fuel00:53:30 Evolution of the Hard-Ass00:57:01 Logic Over Depression01:00:30 The Insulin Sensitivity Debate01:02:24 The False Positive GH Myth01:05:00 Hyperplasia & Skin Quality01:13:02 The Rebuild Blueprint01:18:15 Metrics of Longevity01:21:43 Pharmacological Resilience01:28:13 The Solidification Phase01:31:30 Integrity of the Exit01:37:15 Firing Lagging Chains01:42:30 The Olympia Verdict01:46:27 Spinal Decompression Myth01:52:45 The Art of Mock Peaks01:58:07 Slamming the Rebound02:02:13 Morphing: Endo vs Meso02:15:24 Final Reflections on Empathy

The post Inhaled, Applied, Prescribed: Steroids Through the Allergy Lens appeared first on JDDonline - Journal of Drugs in Dermatology.

The post JDD Podcast: Inhaled, Applied, Prescribed: Steroids Through the Allergy Lens appeared first on JDDonline - Journal of Drugs in Dermatology.

Pour son grand retour dans STEROIDS - LE PODCAST, le fabuleux, sémillant et pétillant Arnaud Bordas (dit "Ernest Bordeau - le plus grand critique de l'histoire du cinéma") accepte l'invitation aux micros de Stéphane Moïssakis pour parler du cheeeeffffe-d'oeeeeeuvre LE FAUCON de Paul Boujenah ! Grand polar existentiel issu de la quatrième dimension du cinéma français, ou nanar cosmique incompréhensible ? Nos deux exégètes des petits bras de Francis Huster n'ont pas encore tranché !Retrouvez toutes nos émissions sur http://www.capturemag.frPour nous soutenir, il y a deux adresses :PATREON : https://www.patreon.com/capturemagTIPEEE : https://www.tipeee.com/capture-magLISEZ CAPTURE MAG !Toutes nos revues sont disponibles dans les librairies, les magasins de produits culturels et sites marchands.Akileos : https://bit.ly/AkilsCM#nanar #polar #cinémafrançais Capture Mag est sur LETTERBOXD : https://letterboxd.com/CaptureMag/ Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Send a textIn this episode of The Corporate Life, host Hina Siddiqui sits down with George Dubuc, a man who has witnessed the evolution of connection from the engineering floors of General Motors in 1967 to the digital chaos of the modern era. Known as "The Ultimate Networker," George shares his perspective on why America is facing an epidemic of loneliness and how the transition from genuine human connection to transactional "dehumanized" units is affecting our mental health.George discusses his journey from building internet infrastructure when people were still asking "what's a website?" to his current role as an author and producer of the TV show America's Real Deal. He offers a candid look at the "noise" of social media, the breakdown of traditional family networks, and his ambitious new mission to launch a "Mastermind" movement for the 2028 U.S. Presidential run focused on logic and facts rather than propaganda.Key TakeawaysThe most important asset in life is who you know and who knows you, yet many people fail to nurture relationships. Modern technology is moving faster than human brain evolution, leading to frustration and a "ghosting" culture where connections are purely transactional. Success in the digital age often rewards those making the most "noise" rather than the highest quality product.Episode HighlightsGeorge reflects on the shrinking of family networks, noting his own hometown gathering dropped from 100 people to just 15 as younger generations delay marriage and reproduction. He also contrasts the "regimented" business world of the 1970s with today's "do your own thing" authenticity, where rules have been replaced by convenience. Finally, he shares his grandfather's secret to a wonderful life: work hard every single day, both physically and mentally.Timestamps00:00 - Introduction to the Ultimate Networker George Dubuc 03:30 - The importance of nurturing long-term relationships 06:00 - The decline of family networks and the rise of loneliness 09:30 - Why human brains are struggling to keep up with technology 22:00 - Evolution of the internet and doing business on the web 26:00 - America's Real Deal: Shark Tank on steroids 34:30 - Social interaction games and the "Sexuality Probe" 40:30 - The 2028 Mastermind Presidential movementConnect with GuestWebsite: theultimatenetworker.com TV Show: americasrealdeal.comConnect with HinaWEBSITE I https://thehinasiddiqui.com/ LINKEDIN I / hinasiddiqui INSTAGRAM I @hinawithwings YOUTUBE I / @thehinasiddiqui Email I hina@thehinasiddiqui.comCheck out Hina's books: https://amzn.to/The Path to ExitFounders—thinking of selling or raising capital? Here's what you should know... Listen on: Apple Podcasts Spotify Make your podcast work for your business - Listen to Podcasting AmplifiedPractical strategies to turn your podcast into a business growth engine.Listen on: Apple Podcasts Spotify

Pat Boyle receives a phone call asking for the creation of a steroids-only Baseball League, making the case that it would actually improve the entertainment factor of the game.

AI is overal, maar hoe zorg je voor échte adoptie binnen je organisatie? In deze aflevering gaat Jochem in gesprek met Eric Mink, VP AI Adoption bij Pax8. Eric is iemand die mentaal al in 2027 of 2028 leeft, maar deze toekomstvisie ijzersterk weet te vertalen naar de realiteit en de uitdagingen van vandaag. We duiken diep in de ‘Intelligence' van AI en wat de razendsnelle ontwikkelingen betekenen voor productontwikkeling. In deze aflevering bespreken Jochem en Eric: Hoe zorg je ervoor dat de hele organisatie (de hut!) écht 'AI-first' gaat denken en werken? De evolutie van onze rol: Hoe ziet het werk van de Product Owner er over een paar jaar uit? AI Agents: Vanaf wanneer is het de normaalste zaak van de wereld dat iedereen dagelijks samenwerkt met autonome agents? Een absolute must-listen voor iedere Product Owner die niet wil achterlopen en zich wil voorbereiden op de AI-revolutie die nu gaande is. De Product Owner Podcast is een initiatief van Productowner.nl

Sign up to Easy Ayurveda Video Classes by clicking the link belowhttps://www.easyayurveda.com/video-classes/Video Course: “Ayurvedic food and Nutrition”https://www.easyayurveda.com/nutrition/Buy Tridosha Made Easy Bookhttps://www.easyayurveda.com/tridosha-made-easy-3/Buy Tridosha Made Easy Book in Spanish LanguageEl corazón de los doshas: Nuevo librohttps://www.easyayurveda.com/el-corazon-de-los-doshas/Click to know more about Easy Ayurveda Hospitalhttps://www.easyayurveda.com/hospital/Buy our new course on Marma Therapy Part 1https://www.easyayurveda.com/marma1Buy our new course on Marma Therapy Part 1Subscribe to Easy Ayurveda Video Classes https://www.easyayurveda.com/video-classes/Subscribe to our free Easy Ayurveda newsletter here (you can unsubscribe and stop them anytime) -  https://forms.aweber.com/form/58/2129766958.htm Buy our course on diabetes reversal, powered by Madhavbaug https://www.easyayurveda.com/diabetes Buy our online video course on Treatment of cardiac disorders with Ayurveda https://www.easyayurveda.com/heartMaster ECG in one week. Sign up for video course https://www.easyayurveda.com/ecgContact Dr. MB Gururaja BAMS MD (Ayu)https://www.easyayurveda.com/gururaja  Contact Dr. Raghuram YS BAMS MD (Ayu)https://www.easyayurveda.com/raghuram Buy Easy Ayurveda Ebooks https://www.easyayurveda.com/my-book Buy Easy Ayurveda Printed Books https://www.easyayurveda.com/books/

In this episode of PEM Currents: The Pediatric Emergency Medicine Podcast, we take a structured, evidence-based approach to the acute treatment of migraine in children and adolescents. From confirming the diagnosis and screening for concerning features to optimizing outpatient therapy and executing a protocolized emergency department strategy, this episode walks through what works. We review the role of NSAIDs and triptans, clarify how IV fluids and ketorolac fit into care, and provide a stepwise framework for dopamine antagonists, valproate bridge therapy, DHE protocols, steroids, discharge planning, and admission decisions. Practical dosing, reassessment timing, and family-centered communication strategies are emphasized throughout. Learning Objectives Recognize the clinical features of pediatric migraine and distinguish it from secondary causes of headache. Implement a stepwise, evidence-based emergency department approach to acute pediatric migraine, including appropriate medication selection and timing of reassessment. Develop safe discharge and follow-up plans by defining treatment endpoints, minimizing medication overuse, and identifying patients who require referral or inpatient management. References 1. Oskoui M, Pringsheim T, Holler-Managan Y, et al. Practice Guideline Update Summary: Acute Treatment of Migraine in Children and Adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019;93(11):487-499. doi:10.1212/WNL.0000000000008095. 2. Patterson-Gentile C, Szperka CL. The Changing Landscape of Pediatric Migraine Therapy: A Review. JAMA Neurology. 2018;75(7):881-887. doi:10.1001/jamaneurol.2018.0046. 3. Bachur RG, Monuteaux MC, Neuman MI. A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department. Pediatrics. 2015;135(2):232-238. doi:10.1542/peds.2014-2432. 4. Ashina M. Migraine. The New England Journal of Medicine. 2020;383(19):1866-1876. doi:10.1056/NEJMra1915327. 5. Richer L, Billinghurst L, Linsdell MA, et al. Drugs for the Acute Treatment of Migraine in Children and Adolescents. The Cochrane Database of Systematic Reviews. 2016;4:CD005220. doi:10.1002/14651858.CD005220.pub2. Transcript This transcript was generated using Descript automated transcription software and has been reviewed and edited for accuracy by the episode's author. Edits were limited to correcting names, titles, medical terminology, and transcription errors. The content reflects the original spoken audio and was not substantively altered. And today we're gonna talk about the acute treatment of migraine headache in children and adolescents. This is bread and butter for the PED, requires precise diagnosis and evidence-based treatment. We're gonna talk about making that diagnosis, red flags, outpatient and ED treatment, as well as some second-line agents, admission decisions, and a whole lot more. So migraine in children is defined by three criteria, and at least five attacks lasting two to 72 hours. So you gotta have at least two of the following: pulsating or throbbing quality, moderate to severe intensity, aggravation by routine activity, and a unilateral location. Although in children, it's often bilateral, plus at least one of nausea or vomiting and photophobia and/or phonophobia. In children headaches are frequently bilateral, bifrontal, bitemporal. The duration might be shorter than adults, especially in kids under second or third grade. And you may have to infer whether or not they have photophobia from their behavior. Like does the child close their eyes or wanna go into a dark room? In the emergency department, we're often diagnosing based on pattern recognition plus exclusion of dangerous secondary causes. Or even more often than that, the patient comes in and says, I've got a migraine. Before I move on to treatments, let's talk about some red flags where you might wanna pause and not just jump to migraine therapy. And the mnemonic SNOOP can be helpful here. And it stands for S for systemic symptoms such as fevers, myalgia, weight loss, or another S, secondary risk factors such as an immune deficiency, cancer, pregnancy, N for neurologic signs, papilledema, focal deficit, confusion, seizures. O onset sudden, or thunderclap. Migraines are often a little more gradual than that. The other O is older age, or technically younger age too, younger than five years or older than 50. Hopefully those patients are not coming into the pediatric emergency department. And then pattern changes, these new symptoms in a previously stable pattern. Don't ignore that. And precipitants, you know, is it worse with Valsalva, position change, or under significant exertion? If these signs are present, you'll probably wanna take a pause and just not throw migraine treatment at the patient. If they're stable, MRI is the preferred imaging modality, but a very sick patient, it'd be okay to get a head CT. If you've got a normal neurologic exam, there's no red flags. Again, you don't need routine imaging for migraine headaches. So let's talk about treatment. So hopefully patients have actually started to treat their headache before they arrive in the emergency department. If they haven't, it's a good idea to have some triage protocols in place. So ibuprofen, 7.5 to 10 milligrams per kilogram, 10 milligrams per kilogram is superior to placebo and it's superior to acetaminophen at two hours. So that's what we would use. Early treatment's critical. So ideally within the first hour of onset. So that's why triage protocols help. We'll give kids 10 mg per kg of ibuprofen and like 30 ounces of Gatorade. Blue is often the first Gatorade choice, though that's not an evidence-based statement. You can also use naproxen, but most of the studies are on ibuprofen. If NSAIDs fail, many adolescents and some older children will be prescribed triptans. The best evidence currently supports sumatriptan plus naproxen or zolmitriptan nasal spray. Rizatriptan is FDA approved down to age six. Adolescents respond to these agents better than younger children, and the route matters. The nasal formulations help when nausea is prominent. Families should be counseled to treat early, use weight-appropriate dosing, and avoid using acute medications more than 10 days per month. Often patients will have already taken an NSAID and a triptan before they get to the ED, and that's where we get into the treatment of refractory migraine. Now this is most of the patients that I will see, and before we push medications, let's briefly review ED treatment goals. You either want the patient headache free. Back to their baseline or mild descending pain. So a pain score of one to three. If you don't reach one of those endpoints and it's not agreed upon with the patient and their family, you've not completed treatments. You should do a reassessment within one hour after each intervention. And let's face it, if you're not reassessing within an hour and defining treatment goals, you're not practicing protocolized migraine care. So in the emergency department, many of you may be familiar with the migraine cocktail. So what is that? In general, it's a dopaminergic agent such as prochlorperazine or metoclopramide plus ketorolac, plus IV fluids. Let's take a look at all three of those components and see if you can guess which one is actually the one that can abort the migraine. So fluids are commonly given in pediatric migraine, but they alone do not treat it. They're helpful. Many patients have been throwing up or a bit dehydrated, but there are small randomized trials that show essentially no meaningful pain reduction in patients that get IV fluids alone. Well, what about ketorolac? Toradol, like that's the first thing you give to a kid with a kidney stone, right? It does help, but it's really adjunctive. So the main first-line agents for refractory or status migrainosus in the emergency department are the dopamine antagonists, and the first-line treatment for most patients is prochlorperazine or Compazine. The dose is 0.15 milligram per kilogram IV. The max is 10 milligrams. This is the backbone of ED migraine care. And why do they work? Well, migraines aren't just some random vascular headache. This is an inherited disorder with central pain pathways gone awry. Dopamine plays a large role in that pain, nausea, hypersensitivity, amplification of symptoms and more that, frankly, I won't get into this podcast because molecules hurt my head. The dopamine antagonists treat the headache, they reduce the nausea, and they just tamp down this process. Overall, the response rates approach 85%. Some studies have suggested that the response rate is about 77% at an hour and 90% at three hours. If you add the ketorolac and IV fluids, you get your response rate up to about 93 to 94%. These agents really do work well together. There have been randomized trials comparing IV prochlorperazine versus ketorolac. 85% of prochlorperazine patients achieved headache relief versus only 55% of ketorolac patients. So ketorolac helps, but really it's the prochlorperazine. Metoclopramide, or Reglan, is used in a lot of centers as well. There are some smaller studies in children and adolescents that show that prochlorperazine is more effective, but if kids have an adverse reaction, more on that in a moment, or they prefer metoclopramide because they've responded to it in the past, it's okay to go with it as well. Right. So what does it actually look like when you give the migraine cocktail to a patient? I think it's important to explain to patients and families what to expect, and if this is a teenager, I'm talking to them directly. I mean, they're getting the medication first and foremost. I tell them that the most effective way to treat their headache is with an IV. This often causes lots of angst, even in older teenagers. The medication just does not get to the brain as effectively and fast enough if you take it by mouth. Many patients who get the dopaminergic agents, so prochlorperazine, will invariably feel jittery or anxious or like they gotta move or like they got ants in their pants. I tell them to expect this so they're not surprised and worried when it happens. I tell them that once they start feeling that way, it means the medicine is probably working. They need to hit the nurse button and we're gonna get them up and have them take a walk. This fixes it for the majority of patients just getting up and moving. In adult centers, even with the initial administration of the prochlorperazine or as sort of a reflexive response to any of those symptoms, they just give a slug of IV Benadryl. There's some studies in adolescents especially that this may decrease the effectiveness of the IV agents you're giving in the first place, and it may also increase return rates to the ED. So I will use IV diphenhydramine if getting up and moving around isn't working, or if the distress is significant, or if the patient clearly indicates they've needed it in the past. So if after the migraine cocktail, the patient has met their pain goals and the reassessment is favorable, they can go home to outpatient follow-up. How about if the headache got better, but not all the way? It's usually when the initial migraine cocktail didn't achieve the pain endpoints fully, like it helped partially. If the dopamine blockade didn't do anything, valproate is unlikely to rescue the case. And so valproate works on GABA and it stabilizes some of these pain processes, but the dopaminergic agent needs to have done something first for valproate to work. Per the most common protocol, you give an initial dose of IV valproate, then you discharge the patient home on Depakote ER. So oral valproic acid under 10 years old or under 50 kilograms, 250 milligrams PO twice a day for two weeks, or older than 10 or greater than 50 kilos, 500 milligrams twice a day for two weeks. This is the extended release and it's most helpful if you give the first oral dose in the emergency department. So that's why it's very important to build this protocol in advance. If you don't have IV valproate, then don't just give the patient oral valproate, and definitely don't prescribe an oral course for discharge. All right, well, what about DHE? Dihydroergotamine for refractory or status migrainosus? Generally, this is only given at pediatric centers where you have neurology coverage. It's contraindicated if you've had another dose of DHE within 14 days, or you've had any triptan of any sort within 24 hours, and you must obtain a pregnancy test in adolescent females before giving it. The dosing for less than 30 kilograms is 0.5 milligram. At least 30 kilograms is one milligram. You give 50% of the dose over three minutes, then the remaining 50% over 30 minutes. If this is gonna work, the patients are gonna start feeling wretched at first. They're gonna get very nauseous and they're gonna vomit. They're gonna have flushing, and you'll see transient hypertension. Most of that resolves within the hour in most centers. If you're committing to DHE, you're kind of bringing the patient into the hospital anyway, though some facilities will have DHE done in the emergency department with close outpatient follow-up. Either way, it's really best practice to involve child neurology if you're giving DHE. Alright, well what about steroids? They give those in grownups too, right? Steroids really only have a role for recurrence prevention in children. So for kids that have a history of returning within 72 hours for rebound headache, you can give dexamethasone 0.6 milligram per kilogram IV dose, the max of 10 milligrams. You do not discharge them home on a steroid prescription or a Medrol dose pack or something else, and this can cut the recurrence risk down a bit. There's other therapies out there like magnesium and ketamine. There's just not enough evidence there. And the purpose of this episode is to discuss the therapies that have good evidence behind them and should be part of protocols across the country. Some patients are unfortunately not responsive to emergency department therapy and need admission. The main inpatient therapy is the DHE protocol. If they're not DHE eligible, they haven't tolerated it well or it's unavailable, admission's unlikely to help them unless they just need some IV fluids to help them get back up on their feet. You should consult neurology if the headache goals are not met after maximizing ED therapy for advice. And we should definitely avoid opioids. They don't treat patients with migraines. They increase recurrence risk. They increase revisit rates. Again, the dopamine antagonist prochlorperazine, it's superior for sustained relief when families ask about them, and fortunately they're asking about opioids far less. We use medications that treat the migraine pain pathways and signaling. We don't just wanna mask the pain. All right, so that's all I've got on the acute management of migraine headaches, especially in the emergency department. Remember that migraine care in the ED should be protocolized and evidence-based. IV fluids are supportive. Prochlorperazine is the first line, or you can use metoclopramide as well. Ketorolac is an adjunctive therapy. Valproate is next line. If you've gotta escalate, and DHE is specialized therapy, you can start in the ED, but most of these patients are getting admitted. Dexamethasone or steroids in children can reduce recurrence risk, but they're not really part of the acute management. You should definitely define the endpoints and structurally and systematically reassess patients at an hour. The goal is to get them feeling better to a defined endpoint and to restore function. There is evidence-based pediatric emergency migraine care. You should understand that, plus how to explain why these agents are being given and some of the side effects to patients and families. I find that that approach increases your likelihood of buy-in and success. Alright, so that's it for this episode on the Acute Management of Migraine Headaches in Children and Adolescents. I hope you found it helpful and I can pretty much guarantee that you're gonna see a patient with a migraine on your next shift. If you've got any feedback or comments, send them my way. If you like this episode, leave a review on your favorite podcast site. It helps more people find the show. Or recommend it to a colleague. If there's other topics that you'd like to hear, send them my way for the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.    

The Derm on RheumNow podcast is a collection of Citations and Content curated for dermatologists – addressing Psoriasis, PsA, CLE, vasculitis, HS, other CTD skin disorders. dermatology drugs, biiologics, JAKs - their use, efficacy and side effects.  Features Dr. Jack Cush, Editor at RheumNow.com.  SHOW NOTES FDA sent a complete response letter to AstraZeneca on their application (BLA) for anifrolumabs (Saphnelo) subcutaneous use in SLE. Despite a positive TULIP-SC trial & EU approval of SC-anifrolumab, FDA & sponsor still have to work things out. CRL reasons are unknown https://t.co/3dNwEyolrj Review of Calcinosis Cutis - Surgical intervent. most effective (excision, curettage, laser ablation, etc). Medical measures inconsistently, partially effective, best if used early & localized (CCB, TCN, probenecid, immunomodulation, biologics, colchicine, NA thiosulfate, & JAKi https://t.co/rv0hQBv6nX Systematic Review of Targeted Rx for Systemic Sclerosis: from 32 RCTs & 2036 pts Rx w/ 23 targeted agents. Guselkumab had greatest effect on mRSS, followed by tofacitinib, inebilizumab, & baricitinib. For FVC, B-cell Rx (belimumab, RTX) had highest efficacy https://buff.ly/vHOSRws Dermatomyositis outcomes w/ 2475 pts (claims) & 1196 pts (EHR). Half had myositis panels & 35% had + MSAbs. Steroid use common in 69% & 74%. HCQ, MTX, MMF. Outocmes (per 1000PYs) wereL all-cause hospitalisation 92, malignancy 15.3, ILD 6.4, and myocarditis 2.1 https://t.co/DJqKGNGX76 Danish DERMBIO registry of psoriasis pts Rx w/ biologics. Among 3790 bionaive pts ustekinumab had best 1-5 yr survival vs (ADA & SEC). In 3403 bioexperienced pts, bimekizumab, guselkumab, & risankizumab had highest 2-year drug survival rate. https://t.co/TInyLPMYkb Real-world study of 1202 #PsA pts shows that secukinumab retention rates were lower w/ smoking (79%/73%/72% in never/former/current smokers) but not w/ obesity (72%/77%/77% in normal/overweight/obese), Adh HR signif. higher w/ former (1.32) & current smokers (1.27)   https://t.co/1REWmod73W Together PSO Trial - Combination Ixekizumab and Tirzepatide Today Lilly announced top line results of the TOGETHER-PsO open-label, Phase 3b trial demonstrating the significant benefits of concomitant ixekizumab (IXE: an IL-17A inhibitor) and tirzepatide (TIR: GLP-1agonist) over https://t.co/YWCjN2NyGM

In this episode, Jay Campbell shares his extensive expertise on hormonal optimization, peptides, fasting, and the future of biohacking to extend lifespan and enhance health. Discover actionable strategies to transform your body and mind, and learn about revolutionary tools that are redefining wellness. Key Topics The science behind GLP1 peptides and their role in ending obesity How therapeutic hormones and peptides support longevity and muscle preservation The impact of modern society's toxins on health and strategies to combat them The importance of metabolic flexibility, sleep, and mindset for longevity How peptides are naturally derived and their delivery systems (injections, patches, oral strips) The potential of emerging technologies like Klotho and Folistatin Jay's journey through hormone therapy, fasting experiments, and biohacking innovations Future trends: peptides becoming mainstream in gyms and clinics Practical tips for implementing fasting, lifestyle, and supplementation Timestamps 00:00 - Introduction: Unlocking human potential through health and longevity 02:42 - Jay's personal journey into hormone therapy and biohacking 07:17 - Using peptides for fat loss, muscle building, and longevity 12:22 - The story behind therapeutic hormones and their transformative effects 14:11 - Fasting as a tool: history, experimentation, and advanced programs 17:24 - Steroids, peptides, and their impact on physical and mental health 22:18 - How peptides target healing, cognition, and metabolic regulation 28:16 - Delivery systems: injections, patches, oral strips, and future innovations 33:04 - The rise of peptides in the biohacking industry and future potential 39:30 - Cost considerations for peptide regimens now and in the future 43:17 - Society's toxins and the importance of quality food sourcing 46:01 - Foundations for longevity: diet, sleep, exercise, and mindset 48:46 - The vision of a future where health optimization is accessible worldwide 50:15 - Age is just a number: inspiring stories of aging with strength and vitality 53:21 - Connecting with Jay: Resources, books, and how to get started Resources & Links Metabolic Awakening with GLP1 Peptides on Amazon  Jay Campbell's Official Website BioLongevity Labs Connect with Jay Campbell X (Twitter) Instagram Email/Contact Thank you for tuning in! Don't forget to check out Jay's books and resources to kickstart your journey toward optimal health and longevity. Disclaimer: This podcast is for educational and personal development purposes only. The views shared are based on personal experience and are not intended to replace professional medical, psychological, or legal advice. Please seek a qualified professional for guidance specific to your situation.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Bone smashing. Steroids. Crystal meth. 13-year-olds letting AI judge their faces. It's called looksmaxxing – and it presents as self-improvement. Underneath, it's a deftly weaponized pipeline to nihilism, misogyny, and self-destruction, consuming millions of young men right now. Adam Skolnick and I sit with all of it this week – what it is, why it's spreading, and what the real antidote looks like. If you have a young man in your life – or you are one – sit with this. Show notes + MORE Watch on YouTube Newsletter Sign-Up Today's Sponsors: Rivian: Electric vehicles that keep the world adventurous forever

In this episode of Formula Fanatics, a subseries of the Drive Thru News podcast, we get ever closer to the upcoming season and logistics for watching races, including F1 coverage moving to Apple TV. We discuss rumors that drivers dislike their new cars and that driving style is changing due to battery regeneration, coasting into corners, rough first-gear behavior, reduced fuel flow, and the removal of DRS, raising concerns about difficult passing and “parade lap” racing. Our hosts give mixed expectations for the season, speculate who might adapt best, predict the year may become dull after a few races, and discuss potential viewership impacts from the Apple TV move.  ===== (Oo---x---oO) ===== 00:00 Race Week Prep: Apple TV, F1 App Access & Getting Subscribed 01:27 Never Miss a Session: Downloading the F1 Calendar + Time Zones 02:35 Max's Endurance Racing Plans: Schedules Moving for ‘Franz Herman' 03:36 Preseason Testing Shock: Drivers Say the New Cars Feel Awful 04:42 New Era Racing: Battery Regen, No DRS & ‘Formula E on Steroids' 07:56 Can Anyone Pass? Slipstream, Dirty Air & Old-School Racecraft 09:49 Who Thrives Now? Best Drivers for Late-Braking, Real Overtakes 10:47 Testing Rumors & Team Noise: Red Bull, Mercedes Sandbagging, Audi Woes? 11:53 Driver Numbers Explained: #1 for Lando, Max's Number Switch & Etiquette 12:56 Livery Talk: Audi & Cadillac + Williams Details 15:52 Grid Updates: Doohan Back as Haas Reserve 17:52 Quick Season Hype Check ... Will Fans Stick Around? Parade-Lap Fears, Rule Changes & Apple TV Impact 19:53 Predictions Time: Who Wins 2026 and Who Definitely Won't 20:37 Fun Send-Off: The Safety Car That Was Too Fast (Super Formula Clip) 21:41 Wrap-Up & Sponsor Shoutouts ==================== Formula Fanatics, is the high-octane sub-series of Break/Fix Podcast's Drive Thru Motorsports News! This is your pit stop for all things Formula 1 — from breaking headlines and race recaps to insider analysis and paddock buzz. The Motoring Podcast Network : Years of racing, wrenching and Motorsports experience brings together a top notch collection of knowledge, stories and information. #everyonehasastory #gtmbreakfix - motoringpodcast.net More Information: https://www.motoringpodcast.net/ Become a VIP at: https://www.patreon.com/gtmotorsports Online Magazine: https://www.gtmotorsports.org/

----- Shout out to all our members who make this content possible, sign up for only $5 a month https://www.youtube.com/channel/UCNNTZgxNQuBrhbO0VrG8woA/join Promote Your Music with No Jumper - https://nojumper.com/pages/promo CHECK OUT OUR ONLINE STORE!!! https://nojumper.com NO JUMPER PATREON http://www.patreon.com/nojumper CHECK OUT OUR NEW SPOTIFY PLAYLIST https://open.spotify.com/playlist/5tesvmDS8h50LkjnSAWMOs?si=j6sJD6DkR4mk5NZZWnlK7g Follow us on SNAPCHAT https://www.snapchat.com/discover/No_Jumper/4874336901 Follow us on SPOTIFY: https://open.spotify.com/show/4z4yCTjwXa4an6sBGIe7m5 iTunes: https://itunes.apple.com/us/podcast/no-jumper/id1001659715?mt=2 Follow us on Social Media: https://www.snapchat.com/discover/No_Jumper/4874336901 http://www.twitter.com/nojumper http://www.instagram.com/nojumper https://www.facebook.com/nojumper http://www.reddit.com/r/nojumper JOIN THE DISCORD: https://discord.gg/Q3XPfBm Follow Adam22: http://www.instagram.com/adam22 adam22bro on Snapchat Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to our monthly conversation with Konstantin, who is one of the most respected voices on YouTube about what is happening Inside Russia. Konstantin Samoilov is a well-known YouTuber whose channel ‘Inside Russia' comments insightfully on Russia's decent into authoritarianism over the last few years. But now, like many others, he's outside Russia, with no idea of when he can return there. ----------LINKS: @INSIDERUSSIA https://www.patreon.com/insiderussiaINSIDE RUSSIA is a source of current news on Russia - Konstantin carefully selects 9 news stories that are important and really matter, with commentaries and analyses by Konstantin delivered daily to channel patrons at Patreon.comGet your access to daily news updates at patreon.com/INSIDERUSSIA----------SUPPORT THE CHANNEL:https://www.buymeacoffee.com/siliconcurtainhttps://www.patreon.com/siliconcurtain----------SILICON CURTAIN LIVE EVENTS - FUNDRAISER CAMPAIGN Events in 2025 - Advocacy for a Ukrainian victory with Silicon Curtainhttps://buymeacoffee.com/siliconcurtain/extrasOur events of the first half of the year in Lviv, Kyiv and Odesa were a huge success. Now we need to maintain this momentum, and change the tide towards a Ukrainian victory. The Silicon Curtain Roadshow is an ambitious campaign to run a minimum of 12 events in 2025, and potentially many more. Any support you can provide for the fundraising campaign would be gratefully appreciated. https://buymeacoffee.com/siliconcurtain/extrasWe need to scale up our support for Ukraine, and these events are designed to have a major impact. Your support in making it happen is greatly appreciated. All events will be recorded professionally and published for free on the Silicon Curtain channel. Where possible, we will also live-stream events.https://buymeacoffee.com/siliconcurtain/extras----------SILICON CURTAIN FILM FUNDRAISERA project to make a documentary film in Ukraine, to raise awareness of Ukraine's struggle and in supporting a team running aid convoys to Ukraine's front-line towns.https://buymeacoffee.com/siliconcurtain/extras----------DESCRIPTION: Inside Russia: Corruption on Steroids, Elite Chaos & Covert Mobilization Jonathan hosts a bimonthly discussion with Konstantin Samoilov about developments 'Inside Russia' approaching the fourth anniversary of Russia's attack on Ukraine. They argue Russia's economic decline is a slow-motion collapse, but the more decisive shift is in Russia's political landscape and social fabric, with corruption accelerating as officials fear the system is becoming unstable. Konstantin describes widespread failures in utilities, healthcare, education, agriculture, and communications, alongside frequent arrests of regional officials, which he says signals a broken “social contract” of loyalty-for-impunity within Putin's vertical of power. He contrasts this with Ukraine becoming “healthier” and more resilient amid attacks, while acknowledging Ukraine's corruption issues but insisting Russia must stop its aggression. The conversation covers how officials allegedly loot state funds as if “there is no tomorrow,” including an example from Belgorod where reconstruction money was allegedly misallocated through falsified damage claims.----------

Une fois encore, l'équipe de STEROIDS - LE PODCAST s'aventure là où on ne l'attend pas. Cette fois, c'est dans les tréfonds des plateformes de streaming, pour rattraper HEADS OF STATE, nouveau film d'Ilya Naishuller (HARDCORE HENRY, NOBODY) avec John Cena, Idris Elba et Priyanka Chopra Jonas (à laquelle il faut rendre hommage, puisque nos deux zouaves n'ont pas été foutus de la nommer durant l'épisode !). Reste la question qui brûle les lèvres de nos chers auditeurs : Avons-nous affaire à l'énième film de streaming de la semaine, ou une bonne surprise qui se consomme sans trop se prendre le chou ? Réponse en écoutant les arguments de Vincent Guignebert et Stéphane Moïssakis dans le podcast du jour !Retrouvez toutes nos émissions sur http://www.capturemag.frPour nous soutenir, il y a deux adresses :PATREON : https://www.patreon.com/capturemagTIPEEE : https://www.tipeee.com/capture-magLISEZ CAPTURE MAG !Toutes nos revues sont disponibles dans les librairies, les magasins de produits culturels et sites marchands.Akileos : https://bit.ly/AkilsCMCapture Mag est sur LETTERBOXD : https://letterboxd.com/CaptureMag/#johncena #headsofstate #actionmovies Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Since the era of Joseph Stalin, Moscow’s rulers have sent Russian athletes into the Summer and Winter Olympics with one command: you must win. These competitors operated under a "win-at-all-costs" doctrine most notably through the use of "shamateurism." By giving elite hockey stars nominal titles as military officers or factory workers, the USSR bypassed amateur requirements to field seasoned professionals against genuine Western students—a disparity that defined the Cold War sporting era. But the deception went deeper than employment records; it extended into the very biology of the athletes, particularly in high-strength disciplines like weightlifting and powerlifting. Athletes such as Vasily Alekseyev, the super-heavyweight lifter who set 80 world records and weighed 360 pounds, were often the face of a system later revealed to be fueled by state-mandated anabolic steroids Today’s guest is Bruce Berglund, author of “The Moscow Playbook: How Russia Used, Abused, and Transformed Sports in the Hunt for Gold.” We look at the intersection of Russian sports and geopolitical power, from the dominant Soviet teams of past Olympics to recent doping scandals and international sanctions. With new research from Olympic archives, records of the Soviet bloc and current Russian media, Berglund shows how Moscow’s leaders have defied the rules of the game for decades as the world’s governing bodies turned a blind eye.See omnystudio.com/listener for privacy information.

Welcome back to another episode of the Couple Casuals Podcast!In this episode, Stefano sits down with Mike Van Wyck — entrepreneur, veteran of the fitness world, and one of the most influential voices in Canadian strength culture — for a raw, unfiltered conversation about training, discipline, masculinity, social media, and what it really means to stay grounded in a noisy world.Mike walks through his journey from competitive football and bodybuilding to working in high-level security, eventually becoming a respected fitness educator with a massive online following — all without ever chasing attention or internet fame. He explains how social media unexpectedly found him, not the other way aroundThroughout the episode, Stefano and Mike dive into:• Mike's early years in football, bodybuilding, and strength training• transitioning from private security into fitness education• why most modern fitness content creates confusion, not clarity• the rise of “analysis paralysis” in training and nutrition• peptides, steroids, and the dangerous shortcuts people take• why enjoyment and consistency matter more than optimization• the clash between old-school gym culture and social media fitness• filming culture, influencer economics, and false expectations• masculinity, discipline, and self-respect through physical effort• training through injuries, aging, and long-term sustainability• why the gym should be a place of presence — not escapismMike also opens up about public perception, controversy, and how quickly narratives form online — offering a rare, grounded look at how media snippets can overshadow years of character, discipline, and lived experience.Grab a casual, lock in, and let's get into it

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: What's More Important, Diet or Exercise? (3:38) Is Adam made of glass? (20:46) The cognitive power of methylene blue and what NOT to take it with. (30:04) Sal the mouse trapper. (34:09) The infamous Hammer Strength machine. (37:15) "Steroid" influencers. (39:54) Another example of using data to twist & mold outcomes to communicate crap. (45:30) The clear pill theory. (49:29) The benefits of liposomal glutathione. (1:00:59) #ListenerCoaching call #1 – Needing guidance on feeling more comfortable in my body and being able to trust the process. (1:03:01) #ListenerCoaching call #2 – What program or training routine is best for me, as someone's goal is to stay injury-free, with my past issues in mind? (1:20:29) #ListenerCoaching call #3 – Looking for advice on what style of training is best for me to continue to build muscle, not feeling so stiff, and advice on controlling binge eating. (1:32:07) #ListenerCoaching call #4 – Looking for advice on staying compliant with military height & weight standards with a history of crash dieting. (1:48:42) Related Links/Products Mentioned Get Coached by Mind Pump, live! Visit: https://www.mplivecaller.com  Visit Troscriptions for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP for 10% off your first order. ** Experience the difference of Liposomal Technology. Use code MINDPUMP for 20% OFF everything. Visit: https://www.rhonutrition.com/discount/MINDPUMP New Program Launch (Feb. 15-28th): MAPS Great 8 (Retail $127, Code: LAUNCH for 50% off!) ** Launch bonuses include: MAPS GREAT 8 Nutrition Guide + 5 Days of Free Coaching with Top Trainer Cole (Only available to those who sign up by the 22nd. Coaching starts on the 23rd.) Mind Pump Store Mind Pump #2187: Why Building Muscle Is More Important Than Losing Fat With Dr. Gabrielle Lyon Mind Pump #2763: Eat as Much as You Want, but Don't Get Fat (JUST follow these 2 rules) Hammer Strength H-Squat -DHS-3042 Trans athletes have no advantage over women, study claims Visit Butcher Box for this month's exclusive Mind Pump offer!  ** New users will receive their choice between Organic Ground Beef, Chicken Breast, or Ground Turkey FREE in every box for a year. ** Mind Pump # 2560: How to Break Free from Destructive Body Image Issues Mind Pump # 2385: Five Reasons Why You Should Hire a Trainer Mind Pump Concierge Coaching Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Ben Pakulski (@bpakfitness) Instagram  

Get our free database with 140+ business ideas: https://clickhubspot.com/kbs Episode 797: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) react to the wildest Elon Musk interview yet.  — Show Notes:  (0:00) We react to the elon podcast (6:11) Evidence of exceptional ability (10:33) Maniacal sense of urgency (11:36) limiting factor (23:31) Human emulators (39:33) Stolen focus (55:39) IDEA: Attention testing — Links: • Full interview - https://www.youtube.com/watch?v=BYXbuik3dgA  • Stolen Focus - https://www.amazon.com/Stolen-Focus-Attention-Think-Deeply/dp/0593138511  • Kumon - https://www.kumon.com/  • Lightwork - https://www.lightworkhome.com/aboutus  — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com  • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC • I run all my newsletters on Beehiiv and you should too + we're giving away $10k to our favorite newsletter, check it out: beehiiv.com/mfm-challenge — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam's List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano /

#199 - Healing Eczema from the Inside Out: Toxins, Steroid Withdrawal & the Identity Shift That Changes Everything with Kat Vong If you've ever looked in the mirror and felt betrayed by your own skin… If you've been told “it's just genetic” or “here's another prescription”… If you're quietly wondering whether something deeper is going on— Stop scrolling. This episode is the one you've been waiting for. Today I'm joined by my friend Kat Vong—host of the Well Done podcast and founder-in-the-making of a clean beauty brand for women with chronic skin struggles. Kat's story is raw, emotional, and wildly empowering. After years of battling off-and-on eczema that left her in physical pain and emotional exhaustion, Kat's body erupted in severe eczema just three weeks before her wedding. We're talking weeping wounds. Steroid injections. Oral steroids. Topicals on repeat. And that was just the beginning. What unfolded over the next several years included topical steroid withdrawal, toxic overload, leaky gut, postpartum depression, a NICU stay with twins at UCLA—and ultimately, a complete identity shift that changed everything. This conversation is about more than eczema. It's about the skin–gut–toxin connection. It's about stress, identity, and the nervous system. It's about what happens when you decide to heal—and cut off every other option. The best news - whether it's your skin or something else, healing.is.possible. In This Episode, We Cover: Heavy metals, phthalates, parabens—and how toxic burden shows up in your skin Leaky gut and why “everything” can suddenly become a trigger Why detox can initially make flares worse The missing piece in chronic healing: identity and mindset The hidden dangers of long-term topical steroid use What topical steroid withdrawal (TSW) actually looks like The beauty industry's blind spots—and what needs to change Practical skin barrier repair from the inside out How meditation rewires your biology (yes, really) Timestamps 00:00 – Meet Kat: severe eczema, beauty industry insider, and the wedding-week flare from hell 02:00 – Three types of steroids in three weeks (and why that mattered later) 03:30 – When the flares came back worse than before 05:00 – Discovering topical steroid withdrawal (TSW) and sleeping on towels 08:00 – The functional testing that changed everything: toxins, gut, inflammation 09:30 – Heavy metals, parabens, phthalates, mold—and why her practitioner was shocked 11:00 – Leaky gut, gluten markers, and the “everything is a trigger” phase 12:00 – Detox + TSW: when healing looks worse before it gets better 13:30 – Pregnancy, temporary glowing skin, and the devastating steroid shot before delivery 15:00 – NICU, postpartum depression, and the emotional toll of skin disease 18:30 – The surprising non-food trigger most people ignore: toxic burden 20:00 – Stress as gasoline on the inflammatory fire 21:30 – “You can't drain the bathtub if the faucet's still running.” 22:30 – Identity work: “I am someone who has eczema” vs. “I am someone who heals.” 26:00 – The meditations that changed her brain (inspired by Joe Dispenza and his books Breaking the Habit of Being Yourself and You Are the Placebo) 29:00 – The desperation loop that keeps people stuck 30:00 – Decide vs. choose: cutting off every other option 31:30 – Skin barrier repair explained simply (bricks + mortar analogy) 34:00 – Makeup, shame, leadership, and not feeling “enough” in the beauty industry 37:00 – Beauty, identity, and self-worth beyond appearance 39:00 – If you feel stuck, here's what you need to hear 41:00 – Turning pain into purpose 42:00 – Kat's upcoming clean beauty brand for chronic skin conditions Let's Talk Root Causes What struck me most in this conversation? It wasn't just the heavy metals or the leaky gut (although yes, those matter). It was this: You cannot heal in the same identity that created the illness. I've seen this over and over in clinical practice. We can remove inflammatory foods. We can support detox pathways. We can rebuild the gut lining. But if someone still believes, deep down, “This is just who I am”… the body listens. Kat didn't just detox her liver. She detoxed her identity. And that's where the shift happened. If You're Struggling with Chronic Condition Right Now… Here's your gentle but firm nudge: Get proper testing. Guessing is exhausting. Reduce inflammation first (you can't drain a bathtub with the faucet running). Support detox pathways before aggressive detox. Repair the gut lining. Regulate the nervous system daily. Decide that healing is happening—even if your eyes haven't caught up yet. Your body is not broken. It's communicating. And as someone who has walked countless women through chronic conditions, autoimmunity, skin flares—I can tell you: when we address toxins, gut integrity, stress, and identity together… things change. Connect with Kat Follow Kat's amazing journey and podcast: Instagram: @thewelldonepod Personal page: @iamkatvong Website: thewelldonepod.com Her upcoming clean beauty line is being formulated specifically for women who have felt invisible in the makeup aisle. And honestly? It's about time. If this episode resonated, send it to the friend who keeps saying, “It's just my hormones,” or “I guess I just have sensitive skin.” Sometimes it's not just sensitive skin. Sometimes it's your body asking for a new story. And that story? It can end very differently than it began.   ✨Join the conversation: Share your thoughts with us on social media or in the comments!

If you're taking steroids, immunosuppressants, biologics like Dupixent, or JAK inhibitors for eczema, you may be wondering how these medications impact your gut and skin microbiome.In this episode, Julia breaks down what the research shows about how different eczema medications affect the immune system, skin barrier, and the gut.She covers: 4 common drug classes: Steroids, immunosuppressants, biologics, and JAK inhibitorsPotential benefits and risks How they may or may not impact the gut & skin microbiomeWhat you can do to support your body while on treatmentThis episode is not anti-medication. It's about understanding how to approach healing in a balanced way by supporting your microbiome, nutrition, and nervous system along with conventional care.Always consult your physician before making any changes to your medications.Work with Julia:⁠Book a Free Consultation⁠Follow Julia on her social⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠@juliachien.rd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!

Send a textA first-round pick, a hometown heart, and a league in flux. We sit down with Kevin Orie to unpack a career shaped by grit, timing, and the unforgiving glare of Wrigley Field. From kicking rocks out of infields in Pittsburgh to a private tryout at Wrigley where he sprinted the bases after BP on instinct, Kevin's story tracks the highs and hard lessons of a young player dropped into a franchise starving for a solution at third base.The rookie season hit like a wave: an 0–14 start, the pressure to transform into a power bat behind Sammy Sosa, and the quiet squeeze of the steroid era altering not just bodies but recovery and confidence. Kevin doesn't hedge. He breaks down how mindset, workload, and the drumbeat of expectations can change a player's identity in weeks. He remembers a shoulder separation that killed a September call-up, a quad tear after a two-mile treadmill test, and a late cut in L.A. when the Beltre controversy closed a door at the buzzer. Through it all, there were anchors: Jim Leyland lighting up the tunnel in St. Louis as the Marlins went back-to-back-to-back-to-back, and Don Baylor's simple inside-pitch drill that later unlocked a swing he didn't know he had.We trace the journeyman years—out clauses, selling himself to third base coaches mid-game, cleanup roles on loaded Triple-A rosters that didn't lead to a phone call—and the eventual return to Chicago on unfinished business. Kevin reveals the difference better development and clearer roles might have made, and how today's strength and swing tech would have sped up his learning curve. Off the field, he opens up about raising three daughters after losing his wife, pivoting into hotel investments and commercial real estate through a recession, and staying in the game with Pirates pre/post on The Fan to keep those clubhouse threads alive.Come for the dugout stories and stay for the clarity about pressure, identity, and resilience. If you've ever wondered how a career can tilt in three weeks—or how a single drill can change a season—this one hits home. Subscribe, share with a baseball fan who loves the human side of the game, and leave a review with the moment that stuck with you most.THANK YOU FOR LISTENING!!!!www.holdmycutter.com

Are Psychopaths As Dangerous As The Legal System Believes?  For decades, judicial systems in North America have been using formal assessments to identify these psychopathic individuals. Scoring high on these tests can lead to harsher sentencing and exclusion from rehabilitation programs based on the controversial belief that such inmates cannot be changed. However, our expert pushes back against these procedures and discusses what modern research is revealing about psychopathy.  Guest: Rasmus Larsen, forensic epistemologist & assistant professor, University of Toronto, author, Psychopathy UnmaskedHost: Elizabeth WestfieldProducer: Kristen Farrah Male Menopause: How To Combat Your Natural Decline In Testosterone  While menopause is a well-known milestone for women, men experience a similar age-related decline in testosterone often referred to as ‘andropause'. This process typically begins around age 40 and is influenced by both natural aging and various lifestyle factors. Our expert explains the numerous signs of low testosterone and how to effectively treat this condition.  Guests: Lisa Fasone, physician assistant, Northwestern MedicineHost: Greg JohnsonProducers: Kristen Farrah Medical Notes: A New Form Of Primary Care, The Hidden Risk Of Suicide, And How To Maintain Muscle StrengthHost: Maayan Voss de BettancourtProducer: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listen to Dr. Tom Roselle, DC and learn how a slipped disc can often be cured or managed without surgery or steroid injections. Approximately 90% of cases improve within a few weeks to months using conservative and non-surgical treatments, as the body can naturally resorb the bulging disc material over time. For more episodes of Ageless Health® with Dr. Tom Roselle, DC please visit: https://www.drtomroselle.com/ageless-health-podcast/ #AgelessHealth @DrTomRoselleDC @WMALDC @RoselleCare #AppliedKinesiology #RoselleCenterForHealing #HolisticHealth #IntegrativeHealth #FunctionalMedicine #HealthEducation #backpain #legpain #sciatica #neuropathy #slippeddisc #herniateddisc

Send a textThe 2026 F1 rules are finally hitting the track—and the drivers are not holding back. Welcome back to the paddock! In this episode, Greeny and the Cheese break down all the chaotic action from Part 2 of the 2026 Formula 1 Pre-Season Testing in Bahrain. With the new engine regulations officially in effect, teams are dealing with massive power drop-offs, and we dive into Max Verstappen and Fernando Alonso's brutal feedback on the extreme "lift and coast" battery management. Is Formula 1 turning into "Formula E on steroids"?Could this be the year Lewis Hamilton secures his elusive 8th World Championship during his second season with Ferrari? We look at Scuderia Ferrari's impressive reliability and massive lap count, while also analyzing Mercedes' potential sandbagging tactics. Plus, we discuss the shocking struggles of the Aston Martin Honda project despite their massive investments and high-profile new hires. Finally, we size up the mid-field, preview the new Cadillac team's entry, and unpack Charles Leclerc's unexpected Pokémon fandom revealed during the Super Bowl.Episode Highlights:The 2026 Engine Drama: Drivers are running out of battery power three-quarters of the way down the straights, forcing massive RPM drops. We break down Nico Hulkenberg's struggles in the Audi to highlight the issue.Driver Frustrations: Max Verstappen and Fernando Alonso are furious about the new driving style required to manage the battery.Hamilton's 8th Title?: Ferrari has looked incredibly reliable by running the most laps across the Barcelona and Bahrain tests. We discuss if Lewis Hamilton's historic "second-year" trend could bring him a championship in red.Aston Martin's Nightmare: Despite new facilities and Adrian Newey's arrival, Aston Martin's new Honda power plant looks like a disaster so far.Mid-Field Battles & Cadillac: Haas is surprisingly looking like a contender for 5th place, Williams and Alpine are showing promise, and the brand-new Cadillac team is expected to start at the back of the grid.Leclerc's Pokémon Secret: A hilarious breakdown of Charles Leclerc being outed as a Pokémon fan during the Super Bowl halftime show. Don't forget to subscribe and leave a 5-star review! We'll be back in two weeks for our ultimate 2026 Season Preview before the lights go out in Melbourne.#F1 #Formula1 #F12026 #F1Testing #MaxVerstappen #LewisHamilton #ScuderiaFerrari #MercedesAMGF1 #AstonMartinF1 #HaasF1 #CadillacF1 #Motorsport #F1Podcast #CharlesLeclerc #pokemonSupport the show

Male Menopause: How To Combat Your Natural Decline In TestosteroneWhile menopause is a well-known milestone for women, men experience a similar age-related decline in testosterone often referred to as ‘andropause'. This process typically begins around age 40 and is influenced by both natural aging and various lifestyle factors. Our expert explains the numerous signs of low testosterone and how to effectively treat this condition.Guests: Lisa Fasone, physician assistant, Northwestern MedicineHost: Greg JohnsonProducers: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The final hour of Evan & Tiki is packed with chaos, controversy, and classic WFAN storytelling. The guys react to Craig Carton putting Todd Hundley on the spot about steroid allegations from the Mitchell Report — and whether anyone even cares about PED accusations anymore. That sparks a deeper conversation about the Mitchell Report itself, George Mitchell's Epstein connections, and what that means (if anything) for baseball history.

How long would it take to revamp your entire business? For Elliott Zelinskas: three weeks. Using Claude Code, he rebuilt his 4-year website, generated 100+ SEO pages, automated YouTube creation and publishing, and replaced parts of his tech stack. All without a dev team. Is agentic AI the next evolution of entrepreneurship? LINKS Follow Elliott on X Follow Elliott on Instagram Meet Elliott and other lifestyle founders inside Dynamite Circle Hang out exclusively with 7+ figure founders in DC BLACK Bento will beat your current email bill — up to 70% off or $300 in credits Million Dollar Weekend by Noah Kagan Live Well on Less Than You Think by Fred Brock CHAPTERS (00:00:00) Intro (00:02:39) Meet Elliott & His Business (00:07:05) How Elliott Started Using Claude Code (00:11:16) Upsides and Downsides of Agentic AI (00:15:13) Simple But Powerful Use Cases for Agentic AI (00:22:07) Six Tips for Non-Tech Founders (00:33:18) Security, Risk, and How to Decide What to Build (00:46:42) Digital Nomading and Personal Finance CONNECT: Dan@tropicalmba.com Ian@tropicalmba.com Past guests on TMBA include Cal Newport, David Heinemeier Hannson, Seth Godin, Ricardo Semler, Noah Kagan, Rob Walling, Jay Clouse, Einar Vollset, Sam Dogan, Gino Wickam, James Clear, Jodie Cook, Mark Webster, Steph Smith, Taylor Pearson, Justin Tan, Matt Gartland, Ayman Al-Abdullah, Lucy Bella. PLAYLIST: Bad Hiring Advice That Can Actually Work: 9 Tactics for Lifestyle Founders 4 Ways to Start a Business From Scratch in 2026 “Scaling on Steroids” with AI Automation ft. Juan Montero

Happened In the 90's hosted by Steve and Matt picks a day, any day, and then goes back in time to that magical decade we all know and love the 90's, to revisit episodes of tv, movies that premiered, or cultural events that occurred on that day in the 90's. This week Steve & Matt discuss the magnitude of MC Hammer's reign at the top, dinosaurs that take performance-enhancing drugs, & Westside Connection stops by King's Tower.SEGMENT 1Show: DinosaursEpisode: "Steroids to Heaven” (Season 3 | Episode: 15)Premiere Date: 2/12/1993Story:Robbie tries to bulk up to impress a girl, but her attention seems to be drawn to a bigger guy named Dolf. When exercise doesn't cut it for Robbie, he resorts to Thornoids and finds out his new, bulky body comes at a high price.SEGMENT 2Show: The Jamie Foxx ShowEpisode: “Westside" (Season 1 | Episode: 17)Premiere Date: 2/12/1997Story: Helen and Junior take a trip and leave Jamie in charge but their no parties rule goes out the window when a hip-hop group wants to use the hotel.

AI in commercial real estate is usually framed around predictions and pricing.   In brief: Underwriting delays come from manual data extraction, not Excel. Institutional CRE teams automate the data layer, not the model. Parsing rent rolls and T12s is now a scale problem, not a staffing one. AI underwriting is being adopted first by lenders and servicers. Speed and consistency are emerging as underwriting risk controls. This Demo Day conversation with Parag Goswami, CEO of Clik.ai, focuses on something more fundamental: how underwriting actually gets done.   The core insight is simple.   The bottleneck in CRE underwriting is not Excel.   It is the manual, error-prone work of pulling data out of PDFs and forcing it into models. Clik.ai does not replace spreadsheets.   It automates everything before the spreadsheet matters by automating the tedious data input to your Excel model and automating it.   That is why its earliest adopters are institutional lenders, servicers, credit teams, and acquisitions pros.   Add to this automated Trepp comparable data and you have a high-value, early underwriting model to screen deals using your own Excel model.   Bottom line Clik.ai eliminates friction in the earliest stage of deal evaluation by automating the grunt work of data inputting giving you faster underwriting and a significant competitive edge.   ***   At GowerCrowd, we are aggressively researching AI tools you can actually use and that bring real, immediate value to your business. Contact us to learn more.   Subscribe to my newsletter and get access to this transformational intel before anyone else:  https://gowercrowd.com/subscribe Email: adam@gowercrowd.com Call: 213-761-1000

Life After Steroids? - Bodybuilding Podcast Episode 77#bodybuilding #TRT #gym #workout #Muscle #Contestprep #bodybuildingpodcastMy Book: ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING Link -⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bodybuilderinthailand.com/ultimate-guide-to-roids/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Daily Text Msg Training 99/month and 1 Hour Phone Call Consult 59 Email to inquire about personal training to steroidspodcast@gmail.com Bodybuilder in Thailand on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/bodybuilderinthailand/⁠⁠⁠⁠⁠⁠ My Other Podcast: Grab the Bull Podcast: ⁠⁠⁠⁠⁠⁠https://youtu.be/X6SzfCrN4NY?si=Ho2T9WIVxLjXo_AE⁠⁠⁠Time Stamps:0:00 Who is using steroids2:54 Maintaining muscle and health after steroid use15:57 Strategies for maintaining muscle on testosterone replacement therapy24:21 Dbol Impact on HPTA and Natural Testosterone28:18 Testosterone Trenbolone Masteron cut stack discussion33:00 Permanent muscel changes from past steroid use39:05 Recovering natural testosterone after 20+ week steroid cycle41:14 Perma Cruise on HGH Enhanced TRT and Health53:46 Manipulating Carbs to Reduce Water RetentionThis Podcast is for entertainment and conversational purposes only. Serious Injury and Death can occur from utilizing chemical performance enhancement. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. The purpose of this podcast is not to glorify the use of PED's but to bring to light the reality of what athletes are doing privately. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.

In this episode of Communicable, Navaneeth Narayanan and Josh Nosanchuk invite Virginie Lemiale and Elie Azoulay (Paris, France) as well as fellow editor Emily McDonald (Montreal, Canada)—this time as guest—to discuss adjunctive steroid therapy for pneumocystis pneumonia (PCP) in HIV-negative individuals. In 2025, Lemiale and Azoulay published results from their double-blind, randomised controlled trial investigating steroid treatment for severe Pneumocystis jirovecii pneumonia (PIC trial) in the Lancet Respiratory Medicine [1]. At first glance, one might dismiss the study's clinical impact due the ‘negative' result of  the primary outcome, mortality at 28 days, which just missed a statistically significant difference between groups. There was a clinical difference, however, and all other outcomes, including 90-day mortality, were significantly different between groups. Understanding how pivotal these results were to clinical practice, McDonald and colleagues sought to contextualise the results of the PIC trial through a Bayesian analysis in a follow-up publication [2]. While the discussion provides useful clinical commentary, it also helps both to demystify Bayesian analysis and to call attention to what might be lost with strict or overly concrete interpretations of traditional frequentist analyses. This episode was peer reviewed by Arjana Zerja from the Mother Theresa University Hospital Center, Tirana, Albania.ReferencesLemiale V, et al. Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2025;13(9):800-808. doi:10.1016/S2213-2600(25)00125-0.Lee TC, Albuquerque AM, McDonald EG. Contextualizing the use of corticosteroids in severe Pneumocystis jirovecii pneumonia through a Bayesian lens. CMI Commun. 2025;2(4):105141. doi:10.1016/j.cmicom.2025.105141.

STEROIDS - LE PODCAST : Quand il s'agit d'évoquer la carrière de héros d'action de Christophe Lambert, on peut dire qu'il y a du choix. Après avoir discuté de RÉSURRECTION avec Julien Dupuy, voici que Stéphane Moïssakis invite Yannick Dahan pour parler de LA PROIE, film d'action totalement oublié des années 90, et dans lequel notre Totophe favori doit combattre des ninjas ! Tout un programme !Retrouvez toutes nos émissions sur http://www.capturemag.frPour nous soutenir, il y a deux adresses :PATREON : https://www.patreon.com/capturemagTIPEEE : https://www.tipeee.com/capture-magLISEZ CAPTURE MAG !Toutes nos revues sont disponibles dans les librairies, les magasins de produits culturels et sites marchands.Akileos : https://bit.ly/AkilsCMCapture Mag est sur LETTERBOXD : https://letterboxd.com/CaptureMag/#christopherlambert #ninja #1990s Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

🧭 REBEL Rundown 🗝️ Key Points 💉 Hydrocortisone Saves Lives:The 2023 Cape Cod Trial (NEJM) showed a clear mortality benefit and reduced need for intubation in severe CAP patients treated with hydrocortisone.📊 Guidelines Are Catching Up:The SCCM (2024) and ERS now recommend steroids for severe CAP, while ATS/IDSA updates are still pending.🔥 Redefining “Severe”:Patients requiring high FiO₂ (>50%), noninvasive or mechanical ventilation, or PSI >130 meet criteria for steroid therapy — even outside the ICU.🍬 Main Risk = Hyperglycemia:Elevated glucose was the most consistent adverse effect, but rates of GI bleed and secondary infection were not increased.🧭 Early, Targeted Use Matters:Start hydrocortisone within 24 hours of identifying severity — especially in patients with high CRP (>150) or strong inflammatory response. Click here for Direct Download of the Podcast. 📝 Introduction Corticosteroids have long sparked debate in the treatment of bacterial pneumonia — once viewed with skepticism, now increasingly supported by high-quality evidence. In this episode, Dr. Alex Chapa joins the REBEL Core Cast team to explore how the 2023 Cape Cod Trial (NEJM) reshaped practice and guideline recommendations for severe community-acquired pneumonia (CAP). 📖 Historical Context & Long-Standing Skepticism For decades, the use of steroids in pneumonia was controversial.Early Use: Steroids entered practice in the 1940s and 50s for autoimmune inflammation, but there was immediate hesitation regarding secondary superinfections.Mixed Data: From the 1980s to the 2000s, small studies emerged on severe pneumonia and ARDS, but the data was inconsistent. Different trials used varying definitions of “severe” pneumonia and different C-reactive protein (CRP) cutoffs, making the data “spread” and easy to “cherry pick” to support or deny a benefit.Past Guidelines: This uncertainty was reflected in official guidelines:2007 (ATS/IDSA): The American Thoracic Society and the Infectious Diseases Society of America did not address the topic due to insufficient data.2019 (ATS/IDSA): Pre-COVID, the guidelines recommended against using corticosteroids in severe CAP. They acknowledged no benefit for non-severe pneumonia, but the data for severe pneumonia was considered too weak to endorse.Pre-Trial Consensus: Prior to 2023, the consensus was to avoid steroids in non-severe pneumonia, while severe pneumonia remained a “gray area” with no treatment showing a clear mortality difference. 📜 The Landmark Cape Cod Trial (NEJM 2023) The Cape Cod trial, published in the New England Journal of Medicine in 2023, reignited the discussion by providing robust, positive data.Trial Design: Phase 3, multi-center, double-blind, randomized, controlled trial.Intervention: 800 patients randomized to two groups, Hydrocortisone as a continuous infusion (200mg/day) versus a placebo infusion.Taper: On day 4, clinicians would decide whether to continue the infusion or begin a taper based on clinical response.Population: Patients with severe CAP, defined by meeting at least one of the following criteria:Pneumonia Severity Index (PSI) > 130.O2 by FiO2 ratio < 300.Need for mechanical or non-invasive ventilation (with PEEP ≥ 5).Need for high FiO2 (>50%) via non-rebreather or heated high flow.Primary Outcomes: Death for any cause 6.2% (hydrocortisone) vs 11.9% (placebo)Secondary outcomes:Death from any cause at 90 days 9.3% (hydrocortisone) vs 14.7% (placebo)Endotracheal intubation 18% (hydrocortisone) vs 29% (placebo)Hospital-acquired infections 9.8% (hydrocortisone) vs 11.1% (placebo)Gastrointestinal bleeding 2.3% (hydrocortisone) vs 3.3% (placebo)Vasopressor initiation by day 28 15.3% (hydrocortisone) vs 25.0% (placebo)Key Findings: The trial demonstrated superiority for hydrocortisone 📋 Updated Guidelines & Current Practice The Cape Cod trial, along with subsequent meta-analyses, has begun to change official recommendations.Society of Critical Care Medicine (SCCM): In 2024, an SCCM expert panel, reviewing the Cape Cod trial and 18 others, strongly recommended corticosteroids for severe CAP. They concluded that steroids reduce mortality and the need for mechanical ventilation.Meta-Analysis (Smit et al.): A 2024 meta-analysis in Lancet Respiratory confirmed the 30-day mortality benefit.European Respiratory Society (ERS): The ERS has issued a recommendation to use steroids for severe pneumonia but still urges caution regarding side effects.ATS/IDSA: As of the podcast recording, the ATS/IDSA had not yet updated their 2019 guidelines. 🛠️ Practical Application for Clinicians Defining “Severe” CAP: The key is to identify patients who qualify as “severe”. This can be done using:Scoring Tools: The PSI is the best validated tool for mortality but is cumbersome. Simpler tools like CURB-65 or SMART-COP are practical and acceptable for defining severity. 2023 meta-analysis from by Zaki et al showed both work well, but CURB-65 has better mortality prediction early on.Cape Cod Criteria: Any patient meeting the trial’s inclusion criteria (e.g., high-flow O2, non-invasive ventilation) qualifies, regardless of location (ED, floor, or ICU).Biomarkers: While not required, a CRP level was used in many studies. A CRP > 150 (Cape Cod) or > 204 (Smit meta-analysis) strongly indicates severe inflammation that would benefit from steroids.Clinical Judgment: A patient who looks “sick,” has “soft” blood pressure, or has dense infiltrates and high oxygen needs (e.g., >50% FiO2 on high flow) is a candidate.Adverse Effects:Hyperglycemia: This was the most significant risk identified, with rates between 6-12%. This is a primary concern, especially in patient populations with high BMI.GI Bleed & Secondary Infection: Fears of these side effects, which contributed to historical skepticism, were not borne out in the Cape Cod trial. The data does not support being overly concerned.Other Side Effects: Mood changes, delirium, insomnia, and agitation in the elderly are known side effects of steroids that were not specifically addressed in the trial but remain clinical concerns. 🔄 Clinical Pathway for Steroids in Severe CAP Unanswered Questions & Future Research Possible remaining questions:Biomarkers: Can we find a more precise CRP level to distinguish moderate from severe disease? Could other markers like ferritin or IL-6 be used? Dosing & Tapering: How much immunomodulation is needed, and when is it truly safe to taper?Gender Differences: Early data suggests females may respond better to steroids and experience fewer side effects. The question of female patients with severe CAP require less corticosteroids needs further exploration. 👉 Clinical Bottom Line The current literature, spearheaded by the Cape Cod trial, now supports the use of corticosteroids in severe community-acquired pneumonia. The best evidence currently points to hydrocortisone, started early (within 24 hours) after severity is identified using a validated tool. While hyperglycemia is a risk, the previous fears of GI bleeding and secondary infections were not substantiated in recent, rigorous trials. 📚 References Chapa-Rodriguez A, Abou-Elmagd T, O’Rear C, Narechania S. Do patients with severe community-acquired bacterial pneumonia benefit from systemic corticosteroids?. Cleve Clin J Med. 2025;92(10):600-604. PMID: 41033846Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941. PMID: 36942789Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e233. PMID: 38240492 Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Alex Chapa, MD PGY 5 Pulmonary Critical Care Fellow Cape Fear Valley Medical Center Fayetteville NC 🔎 Your Deep-Dive Starts Here REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia Corticosteroids have long sparked debate in the treatment of bacterial ... Thoracic and Respiratory Read More The post REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia appeared first on REBEL EM - Emergency Medicine Blog.

Season 7, Episode 21 of Sports Fellowship with Fox and Frank opens in the middle of a true Pennsylvania deep freeze, as Dan Fox and Frank Knight battle sub-zero wind chills, bomb-cyclone warnings, and the kind of winter that hasn't hit this hard in years. With Alan “Action” Jackson sitting this one out (and very vocal about needing time before discussing Bill Belichick and Eli Manning without cussing), the guys set the tone with cold-weather banter before locking in The Deion Sanders Episode.The show kicks off by correcting an omission from last week: congratulations to the Indiana Hoosiers, who capped a historic season by going 16–0 and winning the College Football National Championship—becoming the first undefeated champion in the playoff era. Dan and Frank discuss the fun, drama, and inevitability of complaints in a 12-team playoff format, agreeing that whining has no place when that many teams get a shot.From there, the conversation shifts into one of the most polarizing topics in sports right now: the Pro Football Hall of Fame. The guys break down why Bill Belichick not getting in immediately is indefensible, regardless of how the voting process works, while also debating Eli Manning's Hall of Fame case—agreeing he'll get in eventually, but questioning first-ballot status. Along the way, they touch on other notable names stuck in the logjam, what it really means to “change the game,” and why you simply cannot tell the story of the NFL without Belichick.The episode then pivots to speculation and prediction, with Dan floating a bold take: Bill Belichick's next NFL stop could be the New York Jets. The guys debate ownership, timing, legacy, and whether a 70-something Belichick would even want to walk back into another organizational tire fire.The back half of the show dives deep into Major League Baseball's offseason stalemate. Dan lays out the staggering payroll disparities—Mets and Dodgers north of $320 million, while teams like the Marlins, Rays, and Athletics sit under $80 million—and explains how luxury tax payments alone can rival full team payrolls. The Dodgers' massive financial advantages, deferred contracts, international media revenue, and opt-outs from revenue sharing spark a blunt conversation about competitive balance, small-market accountability, and whether a salary cap (or at least a soft cap) is inevitable.The discussion widens into labor tensions, the looming threat of another MLB work stoppage, and the long-term damage done by the 1994 strike. Steroids, the home run boom, fan trust, and Hall of Fame hypocrisy all come back into focus, with Dan and Frank agreeing on one thing above all else: neither side truly prioritizes the fans, despite claiming they do.The episode wraps with a lighter note—broadcast booths, Mets vs. Phillies coverage, baseball fandom vs. team loyalty—and a reminder that this podcast is still being recorded deep in Dan's basement “bomb shelter,” courtesy of ongoing renovations.Special Thanks to:Fox Brothers Alarms - https://foxbrothersalarms.comFirst Baptist church of Phillipsburg NJ http://www.fbcpburg.org/

The conversation heats up around Bill Belichick's Hall of Fame snub as Joe reacts to the added off-field drama and admits he initially thought the news was a joke. With Hall of Fame voters facing heavy backlash, Joe and the crew debate whether Belichick's cheating scandals should permanently impact his candidacy or if keeping him out for just one year makes no logical sense. They argue that personal feelings shouldn't factor into voting and compare the situation to steroid-era players being left out of Cooperstown. The discussion expands into a broader debate about cheating, legacy, and how both the Pro Football and Baseball Hall of Fame handle controversial candidates.

➢ Learn more about my coaching www.colossusfitness.com➢ Follow us on instagram- https://www.instagram.com/colossusfit/?hl=en➢ Our Youtube channel- https://www.youtube.com/@ColossusFitness/videosWelcome to Motivation Monday, where every Monday we answer all of your questions and have some real talks about life & fitness & get you fired up for the week! In this episode we talk about how to get back on track after sickness, thoughts on steroids and building a brand.Question 1- What's your best way to get back on track after sickness? I find myself wanting to get right back to it, but my energy takes a while to come back. Curious your thoughts.Josh quote: “If you can see it in your mind, you can hold it in your hand.”Kyle quote:  “Pressure is a privilege. Pressure makes a diamond.” snowboard exampleWhat has us excited or intrigued:Client shoutout: KathleenQuestion 2- What are your thoughts on the crazy steroid usage these days with the younger crowd?Question 3- see you guys have 55k followers on Instagram which is crazy impressive. How did you get there? I'm in real estate and want to grow an established brand.Thanks for listening! We genuinely appreciate every single one of you listening.Email me/ submit a mailbox Monday question contact@colossusfitness.com➢Follow us on instagram @colossusfit➢Apply to get your Polished Physique:  https://colossusfitness.com/

Ben Weingarten joins the show to expose “8(a)” an obscure part of federal contracting law that has fueled hundreds of billions in DEI-flavored waste — and which the Trump Admin is only beginning to dismantle. Ryan James Girdusky explains how the 2030 Census could be a tipping point for the Democrats’ ability to win presidential elections. Watch every episode ad-free on members.charliekirk.com! Get new merch at charliekirkstore.com!Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Griffin's favorite psychedelic creepy-cute musical bops! Rachel's favorite psychedelic glass-filled tube!Music: “Money Won't Pay” by bo en and Augustus – https://open.spotify.com/album/7n6zRzTrGPIHt0kRvmWoyaImmigrant Defenders Law Center: https://www.immdef.org/

Send us a textSome years don't just challenge you—they level you. After losing my dad and a dear friend, my body crashed, my energy evaporated, and work I love got painfully scarce. The worst part? I couldn't name why. Steroids, sleep hacks, strict routines—nothing touched the deep, whole-body ache or the fog that made simple tasks feel like mountains. So I did the uncomfortable thing: I kept asking questions until I got real answers.What finally clicked was a second diagnosis layered on my rheumatoid arthritis—fibromyalgia. Suddenly the relentless fatigue, unrefreshing sleep, and unpredictable pain made sense. With my doctor, I started Cymbalta and doubled down on an anti-inflammatory approach to food, cutting sugar and refined carbs and trying carnivore short-term. Within days, my mood lifted and the pain dialed down just enough to start moving forward. Not cured, but hopeful. Not sprinting, but finally walking without shame.That's where a new motto was born: Stack Gold Bricks In 26. Each brick stands for a pillar—health, family, faith, finances, real estate deals, learning, generosity. Big wins are big bricks. Small habits are coins. Both count. I refuse to live in all-or-nothing mode that burns you out and leaves you with nothing to show. This year I'm leaning into practical education—tight YouTube trainings, focused half-day workshops, and back-to-basics real estate strategies for lead generation, fair offers, creative exits, and disciplined follow-through. The market is noisy, but the fundamentals work when you do.If last year bruised you too, you're not alone. Start with one brick you can place today: book the test, ask for help, prep a low-inflammation meal, or do ten minutes of focused work. We'll build momentum together—patiently, honestly, and on purpose. Subscribe, share this with someone who needs a lift, and leave a review to tell me your first brick for 2026. Let's make this the year the small wins stack into something solid. Support the showThanks again for listening. Don't forget to subscribe, share, and leave a FIVE-STAR review.Head to Dwanderful right now to claim your free real estate investing kit. And follow:http://www.Dwanderful.comhttp://www.facebook.com/Dwanderfulhttp://www.Instagram.com/Dwanderful http://www.youtube.com/DwanderfulRealEstateInvestingChannelMake it a Dwanderful Day!

Dorian Yates is a former professional bodybuilder, six-time Mr. Olympia winner and a pioneer of high-intensity, low-volume training for building muscle size and strength. He explains how anyone can vastly improve their fitness, mindset and appearance by training with weights just two or three days per week for less than an hour. We also discuss how to determine your natural strengths and passions and select which life path is right for you. Dorian also shares his journey and transformation from wayward youth to world champion athlete, his exploration of psychedelics, views on cannabis and on longevity and health optimization more generally. The knowledge and wisdom Dorian shares is valuable to men and women of all ages. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David Protein: https://davidprotein.com/huberman Joovv: https://joovv.com/huberman Our Place: https://fromourplace.com/huberman LMNT: https://drinklmnt.com/huberman Function Health: https://functionhealth.com/huberman Timestamps (00:00:00) Dorian Yates (00:03:17) High-Intensity Training, Bodybuilding, Blood & Guts (00:09:15) Muscular Failure, Stimulate & Recover; Anabolics (00:12:04) Sponsors: David & Joovv (00:14:33) Muscle Pump, Stimulus; Recovery Weeks (00:17:32) Beginners & Learning Correct Mechanics; Diabetes (00:22:13) Research vs Real World, Tool: High-Intensity, Low-Volume Training, HIIT Sprints (00:28:53) Bodybuilding Journey, Reading, Training Logs, Aspiration, Parents (00:39:21) Sponsors: AG1 & Our Place (00:42:46) TRT, Steroids, Genetics, Early Bodybuilding Career; Tool: Steroid Risks (00:53:57) Father & Son Relationship; Training Evolution (00:58:31) Workout Intensity & Motivation, Self-Mastery, Transforming Anger (01:05:34) Death; Opportunity Analysis; Bodybuilders, Steroids & Diuretics (01:12:18) Human Possibility, Fitness & Health Progression, Nutrition (01:16:05) Sponsor: LMNT (01:17:26) Mike Mentzer (01:20:42) 1992-1993 Mr. Olympia, Underdog vs Favorite Mindset (01:30:22) Inspiration & Achieving Goal; Retirement, Transition & Identity (01:38:52) Flexibility, Winning vs Loving the Process (01:43:08) Aging, Exercise & Posture (01:46:34) Sponsor: Function (01:48:22) Losing Muscle & Diet Change; Breathing; Health & Mind (01:52:02) Psychedelics, DMT, Ayahuasca, Perspective & Connection (02:01:20) Risks, Research & Psychedelics; Brain Plasticity, Perspective Change (02:06:23) Sunlight & Mood, Schizophrenia, Dopamine, Mitochondria (02:12:15) Cannabis, Smoking & Health; Cancer; Breathwork (02:19:34) Cannabis & Motivation, Individual Variation, THC Levels (02:25:22) Plant Medicine, Kratom, Natural Plants vs Extracts (02:28:53) Training for Women, Losing Fat & Resistance Training; Resilience (02:33:52) DY Nutrition, Supplements; Life Purpose & Consciousness (02:44:40) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply   Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter   What happens when you combine a legendary physique with total honesty? In this episode, I sit down with the one and only Lee Priest at the iconic Gold's Gym in Venice California, to unpack the real foundations of bodybuilding: hard training, simple nutrition, and ruthless consistency. Lee shares what his actual contest prep looked like (including the cycles people still argue about), why modern bodybuilding often looks "softer," and the intensity mindset most lifters have lost. We also go deeper on focus, distraction, and why phones are quietly destroying training quality, and even life quality. If you're serious about building muscle, staying powerful as you age, and cutting through the noise, this one delivers.   5 Bullet Points: Lee's real contest-prep cycle, explained simply Why "more gear" often makes you worse Old school training principles that still win The intensity mindset most lifters avoid Phones, distraction, and lost training quality   About Ben Ben Pakulski is the Chief Performance Officer to elite executives, successful entrepreneurs, and top athletes.With over 25 years of experience, he coaches high achievers to build the physical, psychological, and metabolic resilience required to lead at the highest level. As the creator of the Muscle Intelligence framework, Ben specializes in aligning biology and behavior to drive sustained peak performance. His mission is to redefine what's possible for people in their prime and push the boundaries of human potential.   Guest Bio Lee Priest is a legendary Australian IFBB professional bodybuilder known for world-class proportions, freaky density, and a brutally honest voice in the sport. Rising through the ranks as a teenage standout, Lee earned his pro card in the early 1990s and became one of bodybuilding's most iconic physiques through the late-90s and 2000s. He's respected not just for how he looked on stage, but for how he trained: hard, simple, consistent, and focused on execution over ego. Today, Lee remains a fan-favorite for his unfiltered opinions on modern bodybuilding culture, drugs, training intensity, and what it actually takes to build an elite body.   Time Stamps: 00:00 - Meeting Lee Priest: A Bodybuilding Legend 01:45 - Lee Priest's Early Career and Challenges 03:28 - Training at Gold's Gym: Memories and Changes 07:53 - Competing and Training Philosophy 11:18 - Reflections on Bodybuilding and Life 32:58 - Commonwealth Connections and Prime Ministers 33:13 - First Exposure to Olympia 33:35 - Comparing Bodybuilders: Then and Now 34:18 - Training Techniques and Intensity 42:06 - The Role of Technology in Training 46:23 - The Importance of Family Values 47:06 - The Influence of Social Media 48:15 - Longevity and Health Concerns 53:37 - The Impact of Modern Lifestyle on Kids 56:02 - Concluding Thoughts and Future Plans 57:31 - Personal Reflections on Training and Health 01:00:16 - The Evolution of Training Methods

As promised, I looked over the "Sacralism on Steroids" graphic put out by the "New Christian Right" putting Donald Trump as Constantine (seriously) and noted the simplistic history that always accompanies these kinds of movements. Then we looked at the variant at 1 Timothy 3:16 as it was addressed by my upcoming debate opponent, Dr. Dustin Smith, in a recent podcast. Today's program has a fair amount of graphical information so audio only folks might be missing out on some things.

On this episode of The Fighter and The Kid, Brendan Schaub and Bryan Callen sit down with comedian Nick Simmonsfor a wide-ranging conversation that hits fitness culture, aging, and the thin line between jokes and bad ideas.The guys also talk about why Sydney Sweeney has become the internet's current IT girl, how celebrity momentum actually works, and why certain stars dominate culture at the right moment. Later, they react to Sal Vulcano's TikTok disaster and why short-form content can be brutal for comedians when things go sideways.From gym talk and testosterone jokes to pop culture dominance and social media pile-ons, this episode covers exactly why nothing stays casual once the mics are on.Get this episode and all future episodes AD FREE + 2 extended episodes, Fan Questions, exclusive behind the scenes content and more each month at https://www.patreon.com/tfatkO'Reilly Auto Parts- https://oreillyauto.com/FIGHTERTrue Classic - Upgrade your wardrobe and save on @trueclassic at trueclassic.com/FIGHTER! #trueclassicpod Get this episode and all future episodes AD FREE + 2 extended episodes, Fan Questions, exclusive behind the scenes content and more each month at https://www.patreon.com/tfatkSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.