Podcasts about haplotypes

In this episode, I sit down with my friend and podcast partner, Carrie Bennett, to discuss the mistakes we made when first exploring circadian and quantum biology. We share personal experiences about what worked, what didn't, and how to apply these concepts in a practical way without feeling overwhelmed.  This conversation originally aired on the Quantum Conversations Podcast, so if you enjoy deep dives into quantum health, circadian biology, and everyday wellness, be sure to check it out. We hope you enjoy this fun and insightful discussion about our journey and the lessons we've learned along the way!Topics Discussed: What are some common mistakes we made when first practicing circadian and quantum biology?How sun exposure can impact health, and what did we learn from our experiences?What role do seed oils and aging play in overall wellness?How does light exposure, including infrared and blue light, affect our biology?What are some ways people tend to overcomplicate health, and how can we simplify our approach?Join us at the Return To Nature Retreat| https://www.carriebwellness.com/a/2148042503/mHRys8NMTimestamps: 00:00:00 - Introduction 00:03:55 - Too much sun 00:08:01 - UV light & sun exposure 00:11:52 - Haplotypes and sunshine 00:15:15 - Aging 00:18:33 - Clear blue blockers 00:20:07 - Redlight on water 00:24:34 - Lights at night 00:27:09 - Travel anxiety & overcomplicating health 00:31:37 - Grounding mats 00:34:34 - Traveling & sun exposure 00:38:10 - Return To Nature Retreat Sponsored By: Viva Rays | Go to vivarays.com & use code: YOGI to save 15%Black Lotus Shilajit | Visit: www.blacklotusshilajit.com and Use Code: SARAHK for 15% the entire site!Check Out The Quantum Conversations Podcast!This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesSign up for my newsletter to get special offers in the future! -https://www.sarahkleinerwellness.com/contactFree Guide to Building your perfect quantum day (start here) -https://www.sarahkleinerwellness.com/opt-in-9d5f6918-77a8-40d7-bedf-93ca2ec8387fMy free product guide with all product recommendations and discount codes:https://www.sarahkleinerwellness.com/resource_redirect/downloads/file-uploads/sites/2147573344/themes/2150788813/downloads/84c82fa-f201-42eb-5466-0524b41f6b18_2024_SKW_Affiliate_Guide_1_.pdfMy Circadian App - AppleMy Circadian App - AndroidMy Circadian App - Youtube

In this episode, Kashif Khan and I explore the complexities of health and wellness, discussing why the same diet, supplement, or therapy can have wildly different effects on different people. From hormone replacement therapy (HRT) to exercise regimens, we examine why some people thrive on certain protocols while others experience the opposite—and sometimes even develop serious health issues like cancer or metabolic dysfunction. We also touch on the influence of genetics, mitochondria health, and environmental factors in shaping our health responses. Plus, we're excited to announce a webinar coming at the end of January, where we'll go even deeper into these topics. Join the webinar: https://www.hackmydna.com/sarah Timestamps:  00:00:00 – Introduction 00:04:18 – Kashif's Personal Story and Health Journey 00:07:18 – Health Coaching and Diet Protocols 00:10:12 – Mitochondria Health and Toxin Exposure 00:11:20 – The Role of Genetics in Health 00:15:20 – Women, HRT, and Breast Cancer Risk 00:21:25 – The Power of Genetic Testing for Health Insights 00:25:12 – The Impact of Testosterone Gel 00:32:11 – Symptoms of Hormone Imbalance 00:39:27 – Nervous System Dysregulation and Its Effects 00:43:41 – Why One-Size-Fits-All Diets Don't Work 00:46:51 – The Pros and Cons of High-Protein Diets 00:51:43 – Sarah's Experience with the Carnivore Diet 00:52:56 – Trial-and-Error Approach to Healing 00:53:44 – The Role of Environment in Child Development 00:56:19 – Finding the Root Cause of Your Symptoms 00:57:29 – High-Fat Diets and Insulin Resistance 01:00:16 – The Link Between High Cholesterol and Genetics 01:03:54 – Understanding and Using Hormone Replacement Therapy (HRT) 01:05:12 – Interpreting Blood Test Results 02:08:22 – The Impact of Haplotypes on Health Sponsored By:  Viva Rays Go to vivarays.com & use code: YOGI to save 15% Bon Charge Click here & use code for SARAHKLEINER for 15% off storewide. Check Out Kashif: Instagram Linktree Website This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional! ________________________________________ Get all my free guides and product recommendations to get started on your journey! https://www.sarahkleinerwellness.com/all-free-resources Check out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/courses Sign up for my newsletter to get special offers in the future! -https://www.sarahkleinerwellness.com/contact Free Guide to Building your perfect quantum day (start here) - https://www.sarahkleinerwellness.com/opt-in-9d5f6918-77a8-40d7-bedf-93ca2ec8387f My free product guide with all product recommendations and discount codes: https://www.sarahkleinerwellness.com/resource_redirect/downloads/file-uploads/sites/2147573344/themes/2150788813/downloads/84c82fa-f201-42eb-5466-0524b41f6b18_2024_SKW_Affiliate_Guide_1_.pdf My Circadian App - Apple My Circadian App - Android My Circadian App - Youtube⁠⁠

For more information, visit https://thecirsgroup.com Today we're talking about genes - the genetic haplotypes that predispose you being susceptible to CIRS, or Chronic Inflammatory Response Syndrome. For more information, visit TheCIRSGroup.com   TIME STAMPS: 0:28 Genetics aren't good or bad 1:00 Ancestors of people with CIRS may have been genetically able to survive the black plague 3:07 Why identifying your haplotype can help your recovery and treatment 4:10 Biotoxins are biotoxins 6:16 The Dread Pirate Roberts 6:30 Recap of the various haplotypes 8:02 Genes can be turned on and off 8:45 Testing for CIRS can allow you to better protect your kids 9:25 Be the example for your family   Jacie is a 3 year carnivore, certified nutrition coach, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a wealth and wellness coach, 2 year carnivore and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.   Catch Jacie and Barbara on Judy Cho's podcast to learn more about their health journeys and why they started The CIRS Group: When Carnivores are Affected by Mold Illness - Jacie Gregory & Barbara Williams - https://youtu.be/CR8Uj-d_fok

In this episode, our blood work analyst David Herrera answers our coaches  Sarah, Kelsey, and Jess' questions regarding metabolism and genetics, and the crew gets into a discussion on the Haplotypes and how the environment your ancestors come from may be effecting how you lose fat or gain muscle today. Plus, how you can control the lighting in your environment to make the most of your genetics and metabolism. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.21.348607v1?rss=1 Authors: Olyaee, M. H., Khanteymoori, A. Abstract: Evolution of human genetics is one of the most interesting areas for researchers. Determination of Haplotypes not only makes valuable information for this purpose but also performs a major role in investigating the probable relation between diseases and genomes. Determining haplotypes by experimental methods is a time-consuming and expensive task. Recent progress in high throughput sequencing allows researchers to use computational methods for this purpose. Although, several algorithms have been proposed but they are less accurate when the error rate of input fragments increases. In this paper, first, a fuzzy conflict graph is constructed based on the similarities of all input fragments and next, the cluster centers are used as initial centers by fuzzy c-means (FCM) algorithm. The proposed method has been tested on several real datasets and compared with some current methods. The comparison with the existing approaches shows that our method can be a complementary role among the others. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.14.251835v1?rss=1 Authors: Cao, C., Greenberg, M., Long, Q. Abstract: Many tools can reconstruct viral sequences based on next generation sequencing reads. Although existing tools effectively recover local regions, their accuracy suffers when reconstructing the whole viral genomes (strains). Moreover, they consume significant memory when the sequencing coverage is high or when the genome size is large. We present WgLink to meet this challenge. WgLink takes local reconstructions produced by other tools as input and patches the resulting segments together into coherent whole-genome strains. We accomplish this using an L_0+L_1-regularized regression synthesizing variant allele frequency data with physical linkage between multiple variants spanning multiple regions simultaneously. WgLink achieves higher accuracy than existing tools both on simulated and real data sets while using significantly less memory (RAM) and fewer CPU hours. Source code and binaries are freely available at https://github.com/theLongLab/wglink. Copy rights belong to original authors. Visit the link for more info

Learn how researchers found ancient Neanderthal DNA in human chromosomes. Plus, linguist James Kirby will answer a question about how musicians write songs in tonal languages. In this podcast, Cody Gough and Ashley Hamer discuss the following story from Curiosity.com about how genetecists found Neanderthal DNA in the dark centers of human chromosomes: https://curiosity.im/2xF98kI Want to support our show?Register for the 2019 Podcast Awards and nominate Curiosity Daily to win for People’s Choice, Education, and Science & Medicine. After you register, simply select Curiosity Daily from the drop-down menus (no need to pick nominees in every category): https://curiosity.im/podcast-awards-2019  Download the FREE 5-star Curiosity app for Android and iOS at https://curiosity.im/podcast-app. And Amazon smart speaker users: you can listen to our podcast as part of your Amazon Alexa Flash Briefing — just click “enable” here: https://curiosity.im/podcast-flash-briefing. 

Everyday Einstein explains DNA, SNPs, GWAs, and Haplotypes in Part 1 of his Personal Genetic Testing series. Read the transcript: http://bit.ly/1J4BaWd

Osteopontin represents a multifunctional molecule playing a pivotal role in chronic inflammatory and autoimmune diseases. Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients. Genomic DNA from 2819 Caucasian individuals (n = 841 patients with Crohn's disease (CD), n = 473 patients with ulcerative colitis (UC), and n = 1505 healthy unrelated controls) was analyzed for nine OPN SNPs (rs2728127, rs2853744, rs11730582, rs11739060, rs28357094, rs4754 = p.Asp80Asp, rs1126616 = p.Ala236Ala, rs1126772 and rs9138). Considering the important role of osteopontin in Th17-mediated diseases, we performed analysis for epistasis with IBD-associated IL23R variants and analyzed serum levels of the Th17 cytokine IL-22. For four OPN SNPs (rs4754, rs1126616, rs1126772 and rs9138), we observed significantly different distributions between male and female CD patients. rs4754 was protective in male CD patients (p = 0.0004, OR = 0.69). None of the other investigated OPN SNPs was associated with CD or UC susceptibility. However, several OPN haplotypes showed significant associations with CD susceptibility. The strongest association was found for a haplotype consisting of the 8 OPN SNPs rs2728127-rs2853744-rs11730582-rs11439060-rs28357094-rs112661-rs1126772-rs9138 (omnibus p-value = 2.07×10⁻⁸). Overall, the mean IL-22 secretion in the combined group of OPN minor allele carriers with CD was significantly lower than that of CD patients with OPN wildtype alleles (p = 3.66×10⁻⁵). There was evidence for weak epistasis between the OPN SNP rs28357094 with the IL23R SNP rs10489629 (p = 4.18×10⁻²) and between OPN SNP rs1126616 and IL23R SNP rs2201841 (p = 4.18×10⁻²) but none of these associations remained significant after Bonferroni correction. Our study identified OPN haplotypes as modifiers of CD susceptibility, while the combined effects of certain OPN variants may modulate IL-22 secretion.

The Dniester-Carpathian region has attracted much attention from historians, linguists, and anthropologists, but remains insufficiently studied genetically. We have analyzed a set of autosomal polymorphic loci and Y-chromosome markers in six autochthonous Dniester-Carpathian population groups: 2 Moldavian, 1 Romanian, 1 Ukrainian and 2 Gagauz populations. To gain insight into the population history of the region, the data obtained in this study were compared with corresponding data for other populations of Western Eurasia. The analysis of 12 Alu human-specific polymorphisms in 513 individuals from the Dniester-Carpathian region showed a high degree of homogeneity among Dniester-Carpathian as well as southeastern European populations. The observed homogeneity suggests either a common ancestry of all southeastern European populations or a strong gene flow between them. Nevertheless, tree reconstruction and principle component analyses allow the distinction between Balkan-Carpathian (Macedonians, Romanians, Moldavians, Ukrainians and Gagauzes) and Eastern Mediterranean (Turks, Greeks and Albanians) population groups. These results are consistent with those from classical and other DNA markers and are compatible with archaeological and paleoanthropological data. Haplotypes constructed from Y-chromosome markers were used to trace the paternal origin of the Dniester-Carpathian populations. A set of 32 binary and 7 STR Y-chromosome polymorphisms was genotyped in 322 Dniester-Carpathian Y-chromosomes. On this basis, 21 stable haplogroups and 171 combination binary marker/STR haplotypes were identified. The haplogroups E3b1, G, J1, J2, I1b, R1a1, and R1b3, most common in the Dniester-Carpathian region, are also common in European and Near Eastern populations. Ukrainians and southeastern Moldavians show a high proportion of eastern European lineages, while Romanians and northern Moldavians demonstrate a high proportion of western Balkan lineages. The Gagauzes harbor a conspicuous proportion of lineages of Near Eastern origin, comparable to that in Balkan populations. In general, the Dniester-Carpathian populations demonstrate the closest affinities to the neighboring southeastern and eastern European populations. The expansion times were estimated for 4 haplogroups (E3b1, I1b, R1a1, and R1b3) from associated STR diversity. The presence in the studied area of genetic components of different age indicates successive waves of migration from diverse source areas of Western Eurasia. Neither of the genetic systems used in this study revealed any correspondence between genetic and linguistic patterns in the Dniester-Carpathian region or in Southeastern Europe, a fact which suggests either that the ethnic differentiation in these regions was indeed very recent or that the linguistic and other social barriers were not strong enough to prevent genetic flow between populations. In particular, Gagauzes, a Turkic speaking population, show closer affinities not to other Turkic peoples, but to their geographical neighbors.

Background: The interleukin (IL) 4/IL13 pathway is involved in the regulation of IgE production associated with atopic diseases. Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous association studies have shown conflicting results. Based on their putative functional role, polymorphisms A148G, T1432C and A1652G, located in the coding region of IL4Ra, were selected for association and haplotype studies in a large German population sample (n = 1,120). Methods: Genotyping was performed using allele-specific PCR and restriction-enzyme-based assays. Haplotypes were estimated, and population-derived IgE percentiles (50% IgE >60 IU/ml, 66% IgE >115 IU/ml and 90% IgE >457 IU/ml) were calculated as outcome variables in a haplotype trend regression analysis. Results: In our population, only polymorphism T1432C showed a trend for a protective effect against atopic rhinitis ( odds ratio, OR: 0.52, 95% confidence interval, CI: 0.26 - 1.02, p = 0.05). When haplotypes were calculated, one haplotype was significantly associated with elevated serum IgE levels at the 50th percentile ( OR 1.60, 95% CI 1.08 - 2.37, p = 0.02). Conclusions: These data indicate that IL4Ra polymorphisms, although suggested to be functionally relevant by in vitro studies, have only a minor influence on IgE regulation in our large population sample. Copyright (C) 2004 S. Karger AG, Basel.