Earliest, most basic cause of a specified outcome
POPULARITY
Categories
113 episodes with Root cause
77 episodes with Root cause
29 episodes with Root cause
33 episodes with Root cause
33 episodes with Root cause
18 episodes with Root cause
21 episodes with Root cause
19 episodes with Root cause
13 episodes with Root cause
15 episodes with Root cause
24 episodes with Root cause
14 episodes with Root cause
14 episodes with Root cause
16 episodes with Root cause
21 episodes with Root cause
10 episodes with Root cause
25 episodes with Root cause
14 episodes with Root cause
12 episodes with Root cause
17 episodes with Root cause
13 episodes with Root cause
9 episodes with Root cause
12 episodes with Root cause
11 episodes with Root cause
8 episodes with Root cause
12 episodes with Root cause
12 episodes with Root cause
10 episodes with Root cause
12 episodes with Root cause
7 episodes with Root cause
8 episodes with Root cause
10 episodes with Root cause
10 episodes with Root cause
9 episodes with Root cause
7 episodes with Root cause
7 episodes with Root cause
9 episodes with Root cause
7 episodes with Root cause
8 episodes with Root cause
23 episodes with Root cause
9 episodes with Root cause
8 episodes with Root cause
10 episodes with Root cause
5 episodes with Root cause
13 episodes with Root cause
4 episodes with Root cause
7 episodes with Root cause
11 episodes with Root cause
6 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
9 episodes with Root cause
5 episodes with Root cause
6 episodes with Root cause
8 episodes with Root cause
4 episodes with Root cause
8 episodes with Root cause
8 episodes with Root cause
6 episodes with Root cause
8 episodes with Root cause
8 episodes with Root cause
5 episodes with Root cause
6 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
7 episodes with Root cause
4 episodes with Root cause
8 episodes with Root cause
4 episodes with Root cause
8 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
8 episodes with Root cause
9 episodes with Root cause
8 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
6 episodes with Root cause
4 episodes with Root cause
10 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
7 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
2 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
11 episodes with Root cause
5 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
6 episodes with Root cause
2 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
8 episodes with Root cause
6 episodes with Root cause
4 episodes with Root cause
9 episodes with Root cause
3 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
5 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
2 episodes with Root cause
3 episodes with Root cause
3 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
7 episodes with Root cause
3 episodes with Root cause
3 episodes with Root cause
7 episodes with Root cause
2 episodes with Root cause
7 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
4 episodes with Root cause
3 episodes with Root cause
2 episodes with Root cause
2 episodes with Root cause
3 episodes with Root cause
Welcome back to this week's Friday Review where I can't wait to share with you the best of the week! I'm looking forward to reviewing: Best Early Cancer Testing (product review) Inflammation is a Signal, Not the Root Cause (tip of the week) Lab Grown Chocolate (research) Polylaminin & Spinal Cord Repair (research) For all the details tune into this week's Cabral Concept 3794 – Enjoy the show and let me know what you thought! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3794 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
In this episode I share the definition of PDA I use: PDA is a survival drive for autonomy and equality that consistently overrides other survival instincts, including eating, sleeping, toileting, hygiene, and safety. I explain how this is different from older definitions that consider PDA to be anxiety driven, and why that distinction matters clinically and practically. I also I introduce the concept of equalizing - the behavioral expression of the disability that extends well beyond demand avoidance into physical, verbal, and relational patterns that can look like manipulation, control, or defiance but are actually a nervous system response.Key Takeaways Why the Definition of PDA Matters: Survival Drive vs. Anxiety | 00:02:05 The original framing describes PDA as an anxiety-driven need for control. Anxiety is a future-oriented cognitive experience, and that framing points clinicians and parents toward exposure therapy, medication for anxiety, and pushing through avoidance. My definition is different. PDA is a survival drive for autonomy and equality that operates on a subconscious level, in the nervous system, before conscious thought. A child can love their grandparent, be emotionally attached to their therapist, and genuinely want to go to football practice, and still be accumulating nervous system activation from losses of autonomy throughout all of those experiences. The drive does not require cognitive anxiety to be present. That distinction changes what we do about it entirely. The Survival Drive That Overrides Everything Else | 00:07:35 What makes PDA neurologically distinct, in my conceptualization, is that the survival drive for autonomy and equality can override other basic survival instincts. I share an example from my own life: telling Cooper to stay away from the fire, gently at first, then with more urgency, and watching him move toward it instead of away, then try to jump in. I have also worked with families where a child accelerated into a body of water - without the ability to swim - after being told to stay back. These are extreme examples I use to illustrate the mechanism, not to suggest this is every family's experience, but they show that the PDA nervous system can prioritize autonomy above the instinct to stay safe, which is what can eventually produce the feeding tubes, the selective mutism, and the basic needs collapses that many families in this community have experienced. What Equalizing Is and Why It Looks Like Manipulation | 00:12:31 Equalizing is a nervous system response to get back to a place of perceived equality - or above another - after a loss of autonomy has been registered. It can be physical: disorganizing something that was orderly, knocking things off tables, touching things impulsively, hovering near a sibling, controlling where a parent can sit or look. It can be verbal: correcting words, redirecting blame, pretending not to hear, changing the topic impulsively, lying about things that seem random. It can be directed at a safe person, at a sibling, at objects in the environment, or even at self. The Spices Example: PDA Versus Other Neurotypes | 00:17:11 I use a simple scenario - organizing kitchen spices - to distinguish PDA equalizing from behavior in other neurotypes, inclduing non-PDA autism, OCD, and anxiety. Equalizing Can Be Subtle Until It Escalates | 00:15:36 As cumulative activation builds and the environment continues to signal losses of autonomy without accommodation, these equalizing expressions can escalate toward the large nervous system responses and basic needs struggles I describe in this episode. The goal of everything I teach is to bring down that cumulative activation so families avoid these challenges, or get through them as quickly and smoothly as possible. Relevant Resources Understanding PDA — Free class where I teach the nervous system disability framework, the neuroception mechanism, and the cumulative activation logic introduced in this episode.Burnout — Free class with context for how the survival drive overriding basic needs leads to the burnout state many families are already in when they find this work.Paradigm Shift Program — My signature program where the full framework for understanding PDA, equalizing, and responding to both is taught across twelve weeks of live coaching.
Many people are told their elevated cholesterol and LDL levels are simply the result of diet, lack of exercise, or genetics. But what if rising cholesterol is actually a clue that thyroid physiology is slowing down? In this episode of the Thyroid Answers Podcast, Dr. Eric Balcavage explains the important relationship between thyroid signaling, T4 to T3 conversion, cellular metabolism, liver function, bile production, and cholesterol regulation. He discusses why cholesterol is essential for health, how the body produces and uses it, and why elevated cholesterol may be a sign that the body is struggling to convert food energy into cellular energy efficiently. Dr. Balcavage breaks down several mechanisms by which reduced thyroid signaling may contribute to elevated cholesterol and LDL levels, including decreased T4 to T3 conversion, impaired cholesterol transport, reduced LDL receptor activity, diminished bile production, and impaired bile flow. He also explains why simply lowering cholesterol with medication may not address the underlying physiologic stressors driving these changes. If you've been told your cholesterol is high despite eating well, exercising regularly, and doing all the "right" things, this episode explores why it may be time to look deeper at thyroid physiology, cellular metabolism, inflammation, liver function, and the body's adaptive stress response. In This Episode, You'll Learn: Why cholesterol is essential for hormone production, cell membranes, vitamin D production, brain health, and bile formation How reduced T4 to T3 conversion can contribute to elevated cholesterol and LDL levels The critical role T3 plays in liver function, cholesterol transport, and bile production Why cholesterol may rise even when diet and exercise habits are healthy How impaired bile flow and gallbladder function can affect cholesterol clearance Why elevated cholesterol may be a sign of reduced thyroid signaling rather than simply a dietary problem The lab markers Dr. Balcavage uses to assess thyroid physiology, inflammation, metabolism, and cholesterol regulation Why addressing cellular stress and adaptive physiology is often more important than simply lowering cholesterol numbers Resources Mentioned:
Could Hashimoto's be the missing root cause behind your thyroid symptoms?If you have been told your thyroid labs are “fine,” or you are taking thyroid medication but still feel exhausted, foggy, inflamed, or not like yourself, this conversation will help you understand what may be happening underneath the surface. Hashimoto's is not just a thyroid problem. It is an immune system condition that can keep attacking the thyroid when the deeper triggers are never addressed.Inna Topiler, CNS, MS, is a Certified Nutrition Specialist who has navigated her own Hashimoto's journey for over 25 years. She is the host of Thyroid Mystery Solved: Hashimoto's and Hypothyroidism Revealed, and the creator of Thyroid Love, a 26-nutrient supplement formulated specifically for thyroid autoimmunity.In this conversation with Dr. Shivani Gupta, Inna explains the immune confusion behind Hashimoto's, why thyroid medication alone does not calm the immune attack, and what it really takes to support thyroid health at the root.What You'll Learn in This Episode:Why levothyroxine supports the thyroid but does not address the immune attack causing the damage?How to ask for a real full thyroid panel, and why TPO and TG antibodies matterThe four root cause buckets behind immune confusion: food, infections, toxins, and stressWhy gluten can trigger an immune attack on the thyroid through molecular mimicryThe truth about iodine supplementation with Hashimoto's, and why it often makes things worseHow selenium and inositol support thyroid hormone balance and immune regulationWhy zinc deficiency can be generational and how high copper compounds the problemWhat a thyroid supplement designed for autoimmunity should and should not includeThe Inflammation Codehttps://www.amazon.com/dp/140199699X?tag=usalinktagdefault-20&th=1&psc=1&geniuslink=trueFusionary Formulas SupplementsUse code CODE15 for 15% off your first orderhttps://fusionaryformulas.com/?utm_source=Show+Notes&utm_medium=Show+notes+&utm_campaign=Podcast+promo&utm_id=The+Inflammation+Code+Podcast7-Day Inflammation Detox Challengehttps://www.7dayinflammationdetox.com/Work with Dr. Shivani / Free Discovery Callhttps://shivanigupta.com/
"What if parasites aren't actually the reason you're still sick?" Parasites have become one of the hottest topics in the wellness world. And while they may absolutely be part of the picture... What if the bigger question isn't how do I kill them? What if the real question is: Why are they thriving in the first place? In this episode, we're talking about the missing pieces most people overlook—digestion, minerals, drainage, immune health, and nervous system regulation—and why chasing parasites alone may be keeping you stuck. Related Episode: S3E21: Still Sick? The Hidden Role of Mold, Parasites & Biofilms in Chronic Illness S4E21: The Story Behind the Symptoms: A Endometriosis Case Study
Could chronic inflammation be silently driving fatigue, pain, and chronic disease? In this episode, Dr. Josh Redd, founder of RedRiver Health & Wellness, shares a functional medicine approach to identifying and addressing inflammation at its source. With over a decade of expertise in nutrition, immunology, and regenerative medicine, Dr. Redd helps patients rebalance internal chemistry, optimize performance, and recover from chronic conditions through personalized, precision-guided treatments. His approach combines advanced diagnostics with actionable lifestyle and therapeutic interventions to restore long-term wellness. In this conversation, we explore: · The underlying causes of chronic inflammation and how to detect them. · Key blood markers that reveal hidden imbalances in the body. · How a 30-day inflammation reset can restore balance and improve vitality. · The role of regenerative medicine, nutrition, and lifestyle in healing and recovery. For anyone looking to take control of their health, reduce chronic inflammation, and build a personalized wellness plan, this episode provides practical insights and strategies. Learn more about Dr. Josh Redd and his work here. Episode also available on Apple Podcasts: https://apple.co/38oMlMr Keep up with Dr. Josh Redd socials here: Facebook: https://www.facebook.com/drjoshredd/ X: https://x.com/drjoshredd Instagram: https://www.instagram.com/drjoshredd/ Youtube: https://www.youtube.com/@dr.joshredd2761 Tiktok: https://www.tiktok.com/@drjoshredd
If you've been struggling with your weight for years—or even decades—I want you to hear this clearly: It's not about the food.And in this episode, let's discover how your nervous system is actually controlling your cravings, your habits… and your ability to release weight.The First Agreement I Make With ClientsWhen I begin working with someone, we start with one important agreement: No weighing yourself.I know this can feel uncomfortable, especially when your goal is weight release.But focusing on the scale keeps you stuck in symptoms instead of addressing the root cause.Instead, I guide my clients to focus on:Their patternsTheir behaviorsTheir relationship with foodBecause that's where real change happens.The Real Problem Isn't FoodMost people think their issue is food.It's not.Because if it wasn't food, it could be:AlcoholSmokingAny other coping mechanismThe real issue is: The behavior behind the food.And that's exactly what I focus on.Your Nervous System Is Driving EverythingI look at hormones—but through behavior, emotions, and nervous system regulation.Your autonomic nervous system controls:HungerFullnessCravingsEmotional responsesThere are two key states:Sympathetic (Fight / Flight / Freeze)When you're in this state:Cortisol is elevatedBlood sugar stays highInsulin increasesYour body gets the message to:Store fatEat moreThis is where emotional eating, binge eating, and cravings live.Parasympathetic (Rest & Digest)This is where your body feels safe.And I want you to remember this: Weight release happens in the parasympathetic state.When your body feels safe:Cravings decreaseHormones regulateYour body no longer feels the need to hold onWhy I Don't Focus on Controlling FoodI don't teach people to control food.Because control always backfires.Instead, I focus on:Regulating the nervous systemReducing emotional triggersShifting behavioral patternsAnd when those behaviors fade… Weight release becomes a natural side effect.A Real Client StoryI recently worked with a client who went through a deeply emotional time—she lost her father very suddenly.During that time, our focus was not food.It was:Nervous system regulationEmotional supportProcessing traumaMonths later, she told me: She put on a pair of jeans she hadn't fit into in years… and they fit.We never focused on dieting.We focused on healing.The Root Cause of Emotional EatingSo many eating patterns are tied to:Past traumaStressAnxietyUnprocessed life eventsWhen we:Regulate the nervous systemProcess those experiencesCreate safety in the bodyThe urge to overeat… naturally dissolves.This work is about moving away from control… And stepping into awareness, safety, and real transformation. Because when your body feels safe… it no longer needs to hold on.Struggling with unwanted eating behavior? Download my free guide, Calm the Craving: 7 Steps to Break Emotional and Binge Eating, and finally end the cycle of out-of-control eating: www.sherryshaban.comWork With Sherry Shaban:Book your FREE 30-minute Food Freedom Call and start your journey to lasting change! www.sherryshabanfitness.com/clarityListen & SubscribeCatch more episodes at www.makepeacewithfood.com/podcast or subscribe on Spotify, Apple Podcasts, or YouTube so you never miss an episode!Connect & Go DeeperJoin our Facebook Community: www.myfoodfreedomlifestyle.comWork with Sherry: www.sherryshaban.com/transformExplore more resources: www.makepeacewithfood.comShare Your TakeawayTag us on Instagram (@makepeacewithfoodofficial), Facebook (@MakePeaceWithFoodOfficial), TikTok (@sherryshaban), or LinkedIn (sherryshaban) and share your biggest insight from this episode!
Does Nature really need us to organize forest floors? And do we all suffer from obsessive compulsive disorder (OCD) to some extent? We often think of OCD as being a personal affliction, but as Thom explains in this episode, it's much broader than that, reflecting a general lack of trust in Nature's organizing power. Thom explores OCD through the lenses of entropy, control, addiction, and inner order, and how we can collectively display OCD-like traits. Thom explains how Vedic Meditation can complement existing treatments by helping the brain settle into a more orderly state., and he also shares a simple coming-to-your-senses technique that can help quiet obsessive momentum in the moment. Listen or watch to learn how a deeper experience of inner order can change the way we relate to the world around us. Episode Highlights[00:45] The Search for Order[04:32] Heat Reveals Perceived Disorder[09:24] Nature Orders the Forest[12:50] When Order Turns Dysfunctional[16:22] Meditation Restores Inner Order[20:21] Q - What quiets obsessive compulsive thoughts?[20:36] A - Nature Knows Best How to Organize[22:50] Do Less, Accomplish More[25:53] Come to Your Senses[28:31] Q - Is OCD similar to addiction?[28:42] A - Addiction and External Control[33:11] Growing Field Independence You can also watch this episode on YouTube here: https://youtu.be/PjWnIbONr3I Useful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/
When a child struggles with swallowing, chewing, or food transitions, our first instinct is often to look directly at traditional feeding strategies. But what if the missing piece of the puzzle isn't the food itself, but the foundational resting posture and function of the orofacial muscles?In this solo episode, Hallie Bulkin demystifies myofunctional therapy (Myo) and explores its critical, undeniable overlap with pediatric feeding therapy. She breaks down how addressing underlying myofunctional dysfunction can drastically accelerate your clinical progress, protect airway safety, and create long-term, sustainable outcomes for the children on your caseload.Hallie addresses common misconceptions surrounding Myo, discusses structural considerations like tongue-ties, and explains why a whole-system approach—looking at tongue posture, breathing, and body alignment—is non-negotiable. If you're ready to stop looking at oral motor function in a vacuum and want practical steps to seamlessly weave myofunctional thinking into your next feeding evaluation, this episode is exactly what you need.Key Topics & TakeawaysDefining the Scope of Myo: Understanding what myofunctional therapy actually is and how it targets the resting postures and functions of the oral and facial muscles.The Perfect Partners: Why feeding therapy and Myo should never be treated as entirely separate disciplines, but rather as deeply interconnected systems that support one another.The Trifecta of Function: Exploring how tongue resting posture, nasal breathing, and physical body posture directly dictate a child's success with chewing and safe swallowing mechanics.Debunking Common Misconceptions: Shedding light on the myths surrounding myofunctional therapy and highlighting the evidence-based research that supports its clinical efficacy.Integrating the Assessment: Practical, realistic steps to incorporate orofacial muscle function and structural considerations (like tongue-ties) into your standard feeding evaluations without blowing your timeline.Soundbites"Feeding and Myo are partners, not separate disciplines. When you treat them as a connected system, your outcomes transform.""Addressing myofunctional dysfunction speeds up feeding progress. We cannot build functional feeding skills on top of poor oral resting postures.""Myo literacy makes you a better clinician in any specialty. It completely shifts the lens through which you analyze a child's struggles."Timestamps00:02:29 | Defining Myofunctional Therapy00:03:32 | The Root Cause vs. Symptom Lens00:07:09 | Breaking Through Feeding Plateaus00:11:56 | Where Feeding and Myo Overlap00:14:41 | Airway Management & Nasal Breathing00:18:12 | Debunking the "Just Exercises" Myth00:23:54 | How to Run a Myo Assessment00:30:12 | The 5-Step Integration Framework00:33:33 | The Connected Child SystemLinks & ResourcesClinical Tool: Streamline your assessments and screen for muscle dysfunction F.A.S.T. MYO SCREENING PACKET: Need a simple & science-backed way to screen your patients for potential orofacial myofunctional disorders?WORTH A LISTEN: CONTINUE YOUR JOURNEYThe 4 Layers of Feeding: How to Finally Know Where to StartWhen You Screen a Child and Think 'Now What?STAY CONNECTED
The Fat-Burning Man Show by Abel James: The Future of Health & Performance
Have you ever been told that your labs are normal but you just know something is seriously off? Over the course of our lives, we all experience “mystery symptoms” that seem to come out of nowhere—from bloating, brain fog, and anxiety to thyroid problems and stubborn weight. Today we're getting to the root of the most significant health blind spots of our time—your gut. If you've ever been told “your labs look normal” while you're still dealing with brain fog, anxiety, thyroid issues, stubborn weight, or mystery symptoms no one can explain, you're going to want to listen closely to this one.Joining us today is a longtime friend and true trailblazer in functional medicine, Dr. Izabella Wentz. She's a New York Times bestselling author, an integrative pharmacist, and the woman millions know as the Thyroid Pharmacist. Her new book pulls back the curtain on what's really driving IBS and the tidal wave of gut issues we're seeing today—and more importantly, how to fix them.In this episode, you'll hear:How Izabella's own “stress-related” IBS diagnosis in pharmacy school spiraled into Hashimoto's and autoimmunity—and how she reversed itWhy one bad bout of food poisoning, a moldy apartment, or a round of meds can quietly reset your “normal” from 100% to 80%The overlooked role of parasites, mold, Candida, SIBO, and meds like birth control and metformin in wrecking your digestionWhy “healthy” processed foods, sugar alcohols, gums, and fake fibers can quietly fuel gut chaosPractical strategies to finally get your digestion and energy backIf you're tired of being dismissed by doctors and ready to understand what your gut has been trying to tell you for years, this conversation could be a serious turning point.Find Dr. Izabella Wentz and her work at: New Book: IBS: Finding and Treating the Root Cause of Irritable Bowel SyndromeWebsite: https://thyroidpharmacist.com/Podcast: Thyroid Pharmacist Healing Conversations with Dr. Izabella WentzFacebook: @ThyroidLifestyleInstagram: @izabellawentzpharmdYouTube: @ThyroidPharmacistPinterest: @thyroidpharmdTikTok: @izabellawentzWant help tracking whether certain foods are triggering your gut issues? Try the new Wild Habits app. You'll get instant personalized feedback on your meals, fitness, sleep, HRV and more, along with access to time-tested real food meals proven to get epic results.Get the Wild Habits App here and lock-in 20% savings (expires Sun, June 21)Please take a moment to make sure you're subscribed wherever you listen to podcasts, and to stay up-to-date, sign up for my newsletter at AbelJames.com.You can also join Substack as a free or paid member for ad-free episodes of this show, to comment on each episode, and to hit me up in the DM's. Join at abeljames.substack.com. And if you're feeling generous, write a quick review for the Abel James Show on Apple or Spotify. You rock.
In this clip from Insights at the Edge, Tami asks Thích Nhất Hạnh — revered Zen master, founder of Plum Village, and father of modern mindfulness — what lies beneath all of the world's suffering. His answer is both radical and surprisingly intimate: the root of social change is inner awakening, and it begins with you, right now. Recorded more than two decades ago; somehow more urgent today.This episode is sponsored by Omega Institute, a global gathering hub for lifelong learning and spiritual exploration. Omega offers weekend workshops, special events, rest and rejuvenation retreats, professional training, online learning, and more. Discover what calls to you at eomega.org/true.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
What if inflammation is the missing link behind so many of the symptoms women experience after 40? In this solo episode, Dr. Mariza breaks down the powerful connection between low-grade chronic inflammation, metabolic dysfunction, hormone changes, brain health, energy production, and accelerated aging. She explains why inflammation is far more than an immune system issue and how it silently influences nearly every aspect of health during perimenopause and menopause. Many women assume that fatigue, brain fog, stubborn belly fat, poor sleep, anxiety, joint pain, cravings, and declining energy are separate issues requiring separate solutions. But Dr. Mariza reveals how these symptoms are often interconnected through one common underlying process: inflammation. She also explores why perimenopause is not simply a hormone transition but a metabolic, vascular, and neuroendocrine transition that increases inflammatory burden and changes how the body responds to stress, blood sugar fluctuations, sleep disruption, and hormonal shifts. Most importantly, Dr. Mariza shares the practical lifestyle pillars she uses to lower inflammation, improve metabolic flexibility, support hormone health, and create the internal environment needed for healthy aging and long-term vitality. If you've been feeling like your body is changing but can't quite connect the dots, this episode will help you understand what inflammation may be trying to tell you. IN THIS EPISODE Why low-grade inflammation is one of the biggest drivers of symptoms after 40 The connection between inflammation, metabolism, hormones, and aging How perimenopause increases inflammatory burden throughout the body The labs Dr. Mariza recommends to assess inflammation and metabolic health Why blood sugar regulation is one of the fastest ways to lower inflammation The critical role of muscle, movement, sleep, and nervous system regulation How gut health influences inflammation, immunity, and metabolism Practical daily habits that help reduce inflammation and support healthy aging QUOTES“The goal isn't simply to lose weight. The goal is creating an internal environment where the body no longer feels the need to stay inflamed.” “One workout cannot undo eight hours of sitting.” “When inflammation comes down, everything goes up.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Fix Your Metabolism Masterclass Joi & Blokes Lab Testing Blood Sugar Hacks Guide RELATED EPISODES 755: What If Your Body Isn't Broken, Just Undernourished? The Missing Link Between Nutrients, Hormones & Energy with Ryan Woodburry 753: The Brain's Hidden Role in Chronic Pain, Migraines & Fatigue with Dr. Howard Schubiner 751: Bloating, Brain Fog & Hormone Chaos? Your Gut May Be the Root Cause with Dr. Cassie Smith 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel
Big Sal is done knocking on wood. After two years of heartbreak, Marshawn Lloyd finally got to the bottom of his endless injuries—an undiagnosed college ACL tear that had his body compensating for six years. The Packers' explosive third-round back is healthy for the first time, earning the nickname 'Yeet Cannon' from the coaches, and could be the difference-maker if Josh Jacobs misses time. - Lloyd flew to elite performance doctor John Meyer in El Segundo and fixed the weak quad and compensation patterns that caused every previous hamstring, hip, and ankle issue. - With only six career carries, the speed demon is the fastest, quickest back on the roster and did a backflip at the charity softball game. - Training camp opens July 29th and Sal is choosing to believe the motor stays running this time. Hit that subscribe button and leave a five-star review if the Yeet Cannon makes you a believer. If he goes down in Week 1, come back and roast Sal—he'll deserve it. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Check out everything I'm building across the Packers and NFL world: NFL Draft Grades: https://nfldraftgrades.com/ Hashmarks: https://hashmarks.io/
Have you been told you have IBS, been given a prescription, and sent on your way? That's exactly what happens to tens of millions of people. An IBS diagnosis doesn't explain anything. It's just a label for symptoms with over 30 possible underlying causes, most of which conventional medicine doesn't investigate. In this episode, I'm joined by my friend Dr. Izabella Wentz, who shares her irritable bowel syndrome experience and her husband's ulcerative colitis diagnosis that went into remission within eight weeks of using a root-cause protocol. She breaks down exactly how gut dysbiosis, parasites, mold exposure, glyphosate, stress, hormonal imbalances, and even your medications could be driving your symptoms. If you've been living with IBS and not getting answers, this episode has a helpful roadmap. Izabella walks through the first steps you can take today, how functional testing would help, and why the right protocol depends entirely on finding your root cause. "There are over 30 root causes of IBS. Conventional medicine doesn't really talk about most of them, and most of them are glossed over." ~ Dr. Izabella Wentz In This Episode: - Izabella's experience with IBS - What IBS really is and its most common root causes - How different toxins lead to gut dysbiosis - Why conventional doctors miss IBS - How stress and anxiety trigger IBS - Probiotics: when they help and when they hurt - First steps to identify your root cause - GLP-1 medications and digestive side effects - Functional stool testing and GI-Map explained - Her husband's ulcerative colitis remission story Products & Resources Mentioned: Izabella Wentz's book, "IBS: Finding and Treating the Root Cause of Irritable Bowel Syndrome": Check it out at https://thyroidpharmacist.com/ibs-book-order/ Puori Grass-Fed PW1 Whey Protein: Use code WENDY20 to save up to 32% off your order and a free shaker worth $25 at https://puori.com/wendy Tru Energy Skincare Bio Adaptive Hydration Oil: Try the oil and save up to $197 at trytruenergy.com/wendy5 Organifi Collagen: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox Organifi Happy Drops: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox Heavy Metals Quiz: Check your toxicity score and receive a free video series on how to detox your body at https://heavymetalsquiz.com About Dr. Izabella Wentz: Dr. Izabella Wentz is a compassionate, innovative, solution-focused integrative pharmacist dedicated to finding the root causes of chronic health conditions. Her passion stems from her own diagnosis with Hashimoto's thyroiditis in 2009, following a decade of debilitating symptoms. As an accomplished author, Dr. Wentz has written several best-selling books. Her latest, IBS: Finding and Treating the Root Cause of Irritable Bowel Syndrome, explores a root cause perspective on gut health. Drawing on professional insight, current research, and real-world strategies, she outlines clear, practical steps to help readers identify the drivers of gut dysfunction, follow gentle healing protocols, and finally feel better from the inside out. Learn more about her work at https://thyroidpharmacist.com/ Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Fat-Burning Man by Abel James (Video Podcast): The Future of Health & Performance
Have you ever been told that your labs are normal but you just know something is seriously off? Over the course of our lives, we all experience “mystery symptoms” that seem to come out of nowhere—from bloating, brain fog, and anxiety to thyroid problems and stubborn weight. Today we're getting to the root of the most significant health blind spots of our time—your gut. If you've ever been told “your labs look normal” while you're still dealing with brain fog, anxiety, thyroid issues, stubborn weight, or mystery symptoms no one can explain, you're going to want to listen closely to this one.Joining us today is a longtime friend and true trailblazer in functional medicine, Dr. Izabella Wentz. She's a New York Times bestselling author, an integrative pharmacist, and the woman millions know as the Thyroid Pharmacist. Her new book pulls back the curtain on what's really driving IBS and the tidal wave of gut issues we're seeing today—and more importantly, how to fix them.In this episode, you'll hear:How Izabella's own “stress-related” IBS diagnosis in pharmacy school spiraled into Hashimoto's and autoimmunity—and how she reversed itWhy one bad bout of food poisoning, a moldy apartment, or a round of meds can quietly reset your “normal” from 100% to 80%The overlooked role of parasites, mold, Candida, SIBO, and meds like birth control and metformin in wrecking your digestionWhy “healthy” processed foods, sugar alcohols, gums, and fake fibers can quietly fuel gut chaosPractical strategies to finally get your digestion and energy backIf you're tired of being dismissed by doctors and ready to understand what your gut has been trying to tell you for years, this conversation could be a serious turning point.Find Dr. Izabella Wentz and her work at: New Book: IBS: Finding and Treating the Root Cause of Irritable Bowel SyndromeWebsite: https://thyroidpharmacist.com/Podcast: Thyroid Pharmacist Healing Conversations with Dr. Izabella WentzFacebook: @ThyroidLifestyleInstagram: @izabellawentzpharmdYouTube: @ThyroidPharmacistPinterest: @thyroidpharmdTikTok: @izabellawentzWant help tracking whether certain foods are triggering your gut issues? Try the new Wild Habits app. You'll get instant personalized feedback on your meals, fitness, sleep, HRV and more, along with access to time-tested real food meals proven to get epic results.Get the Wild Habits App here and lock-in 20% savings (expires Sun, June 21)Please take a moment to make sure you're subscribed wherever you listen to podcasts, and to stay up-to-date, sign up for my newsletter at AbelJames.com.You can also join Substack as a free or paid member for ad-free episodes of this show, to comment on each episode, and to hit me up in the DM's. Join at abeljames.substack.com. And if you're feeling generous, write a quick review for the Abel James Show on Apple or Spotify. You rock.
Big Sal is done knocking on wood. After two years of heartbreak, Marshawn Lloyd finally got to the bottom of his endless injuries—an undiagnosed college ACL tear that had his body compensating for six years. The Packers' explosive third-round back is healthy for the first time, earning the nickname 'Yeet Cannon' from the coaches, and could be the difference-maker if Josh Jacobs misses time. - Lloyd flew to elite performance doctor John Meyer in El Segundo and fixed the weak quad and compensation patterns that caused every previous hamstring, hip, and ankle issue. - With only six career carries, the speed demon is the fastest, quickest back on the roster and did a backflip at the charity softball game. - Training camp opens July 29th and Sal is choosing to believe the motor stays running this time. Hit that subscribe button and leave a five-star review if the Yeet Cannon makes you a believer. If he goes down in Week 1, come back and roast Sal—he'll deserve it. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Check out everything I'm building across the Packers and NFL world: NFL Draft Grades: https://nfldraftgrades.com/ Hashmarks: https://hashmarks.io/
If you have lived with acid reflux, heartburn, bloating, or stomach pain that will not go away, even after PPIs, elimination diets, and round after round of doctor visits, this conversation is for you. For over five years, Jessica Washington cycled through the ER, a PPI, a SIBO label, and increasingly restrictive diets, with no real answers. Her H. pylori test even came back negative, something that happens far more often than most people are told. Everything changed when she ran functional labs with a Functional Diagnostic Nutrition practitioner and finally saw what was driving her symptoms. Host Michele Scarlet and Jessica, now an FDN practitioner and founder of The Gut Healing Ninja, get into: Why upper-gut symptoms like reflux and gastritis often start outside the stomach Why a negative H. pylori test does not always mean you are in the clear What a GI Map reveals that standard testing misses The gut-brain connection and the invisible weight of managing symptoms daily How addressing root causes gave Jessica her health, energy, and family back Find Jessica, The Gut Healing Ninja: Instagram: https://www.instagram.com/theguthealingninja Website: https://theguthealingninja.com FDN grads and trainees, this one is for you. Ready to turn your certification into a practice that actually fills up? Our Business Builder Challenge kicks off July 13th, built to give you the structure, accountability, and momentum to start landing clients. Want in? Registration Opens Soon! This content is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before making changes to your health routine.
Stress is one of the most common Hashimoto's triggers. You already know you have stress. The question is, what do you actually do about it? In this episode of the Root Cause Series, Esther breaks down the two sides of stress, what it looks like across all five areas of your life, and how identifying your personal stressors can make a real difference for your immune health. In this episode, you'll learn: Why stress has two sides and why both matter when you have Hashimoto's How to look at stress through the five areas of the whole you: body, mind, spirit, diet, and environment What Esther did about one of her biggest personal stressors and how it showed up in her labs Hit play and start getting clear on where stress fits into your Hashimoto's picture. Hashimoto's Decoded: Root Causes Revealed https://healthwithhashimotos.com/hashimotos-decoded/ Related Episodes: Episode 007: Stress, Your Thyroid, and Hashimoto's Episode 008: 5 Tips for the Busy Woman to Reduce and Manage Stress Episode 024: Your Adrenal Glands, Chronic Stress, and Hashimoto's Autoimmune Disease Episode 034: Halt the Damage Caused by Stress Episode 036: Using Art to De-Stress [Episode 040: Spiritual Stress, Inflammation, and Autoimmune Diseases like Hashimoto's] JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Unlock your wellness journey with the free Health with Hashimoto's community! Join a supportive community that's here for you every step of the way. The Health with Hashimoto's community is on Skool: https://www.skool.com/health-with-hashimotos/about Find all links on my resource page: https://healthwithhashimotos.com/resources/ ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure or prevent any disease.
THE EMBC NETWORK featuring: ihealthradio and worldwide podcasts
Why You're Still Sick: Finding the Root Cause with Reed Davis What if your symptoms aren't the problem—but the body's message? In this powerful episode of The Hurricane H Show, we sit down with Reed Davis, founder of Functional Diagnostic Nutrition® (FDN), to explore the hidden stressors and underlying imbalances that often drive chronic health issues. With more than 25 years of experience and over 10,000 clients served, Reed shares how functional lab testing, holistic lifestyle medicine, and personalized wellness strategies can help people uncover what's really going on beneath the surface. From autoimmune disease and chronic pain to nutrition, stress, hormones, and environmental influences, this conversation offers a fresh perspective on health and healing. Holistic Health Practitioner & Functional Lab Training Program | FDN THE EMBC NETWORK - YouTube https://www.youtube.com/@THEEMBCNETWORKOFFICIAL #FunctionalMedicine #Wellness #ChronicIllness #HolisticHealth #Nutrition #HealthOptimization REVIEW Reed, thank you for being on the show. What an incredible conversation packed with practical wisdom, decades of experience, and a refreshing perspective on health and wellness. Your passion for helping people uncover the root causes of chronic health issues is evident in everything you do. The insights you shared regarding functional testing, lifestyle medicine, and proactive health management provide tremendous value for anyone seeking to improve their quality of life. Our audience walked away informed, empowered, and inspired to take greater ownership of their health journey. Warm Regards, Hurricane H Host | THE EMBC NETWORK Founder | iHealthRadio "Educate. Enlighten. Inspire. Motivate." "Enrich Your Mind & Soar Beyond Limits"
THE EMBC NETWORK featuring: ihealthradio and worldwide podcasts
Why You're Still Sick: Finding the Root Cause with Reed Davis What if your symptoms aren't the problem—but the body's message? In this powerful episode of The Hurricane H Show, we sit down with Reed Davis, founder of Functional Diagnostic Nutrition® (FDN), to explore the hidden stressors and underlying imbalances that often drive chronic health issues. With more than 25 years of experience and over 10,000 clients served, Reed shares how functional lab testing, holistic lifestyle medicine, and personalized wellness strategies can help people uncover what's really going on beneath the surface. From autoimmune disease and chronic pain to nutrition, stress, hormones, and environmental influences, this conversation offers a fresh perspective on health and healing. Holistic Health Practitioner & Functional Lab Training Program | FDN THE EMBC NETWORK - YouTube https://www.youtube.com/@THEEMBCNETWORKOFFICIAL #FunctionalMedicine #Wellness #ChronicIllness #HolisticHealth #Nutrition #HealthOptimization REVIEW Reed, thank you for being on the show. What an incredible conversation packed with practical wisdom, decades of experience, and a refreshing perspective on health and wellness. Your passion for helping people uncover the root causes of chronic health issues is evident in everything you do. The insights you shared regarding functional testing, lifestyle medicine, and proactive health management provide tremendous value for anyone seeking to improve their quality of life. Our audience walked away informed, empowered, and inspired to take greater ownership of their health journey. Warm Regards, Hurricane H Host | THE EMBC NETWORK Founder | iHealthRadio "Educate. Enlighten. Inspire. Motivate." "Enrich Your Mind & Soar Beyond Limits"
What if one of the biggest missing pieces of perimenopause isn't hormones at all? In this eye-opening conversation, Dr. Mariza sits down with Ryan Woodbury, co-founder and co-CEO of Needed, to explore why nutrient deficiencies may be one of the most overlooked drivers of fatigue, brain fog, low energy, poor stress resilience, and other common symptoms women experience during perimenopause. Ryan shares the surprising personal experience that led her into the world of nutritional science and supplementation, including discovering her own nutrient deficiencies despite following a highly nutrient-dense diet. Together, they unpack the alarming research showing that most women are entering pregnancy, postpartum, and eventually perimenopause already running on depleted nutritional reserves. They discuss the shortcomings of traditional nutritional recommendations, why so many women remain deficient despite taking standard multivitamins, and how decades of stress, caregiving, disrupted sleep, pregnancies, and modern environmental demands create a perfect storm for depletion. Dr. Mariza and Ryan also dive into the critical role nutrients play in supporting hormone production, brain function, metabolism, cellular energy, blood sugar regulation, and healthy aging. Most importantly, they offer practical guidance for building a stronger nutritional foundation so women can thrive through midlife and beyond. If you've ever wondered why you still feel depleted despite doing "all the right things," this conversation will help connect the dots. RYAN WOODBURY Ryan Woodbury is the co-founder and co-CEO of Needed, a company dedicated to improving nutritional support for women across every stage of life. With a background in environmental science, nutrition, and food systems, Ryan has become a leading advocate for evidence-based nutrient support for fertility, pregnancy, postpartum, and perimenopause. Her mission is to help women move beyond bare-minimum nutrition and build the foundation needed for lifelong vitality. IN THIS EPISODE Why nutrient deficiencies are so common among women entering perimenopause The hidden impact of stress, caregiving, pregnancy, and postpartum depletion Why traditional multivitamins often fail to meet women's nutritional needs The critical role of vitamin D, magnesium, choline, omega-3s, and B vitamins How nutrient deficiencies contribute to fatigue, brain fog, and metabolic dysfunction Why foundational nutrition matters before adding targeted interventions The connection between blood sugar regulation, inflammation, and hormonal health How women can build a stronger foundation for energy, cognition, and healthy aging QUOTES“95% of women have at least one nutrient deficiency in a very key nutrient.” “You deserve to get what your body actually needs, not the bare minimum.” “When women reclaim their energy, they don't just change themselves, they change the world.” RESOURCES MENTIONED Subscribe now and get 20% off + FREE Shipping on your first NEEDED Supplement Order http://thisisneeded.com/DrMarizaSnyder Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Needed Website Needed InstagramNeeded Facebook Needed Academy Instagram RELATED EPISODES 754: How to Find Joy When Life Doesn't Go According to Plan with Amberly Lago 751: Bloating, Brain Fog & Hormone Chaos? Your Gut May Be the Root Cause with Dr. Cassie Smith 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan
If you've ever been told your thyroid labs are "normal" but you still feel exhausted, cold, constipated, anxious, inflamed, or unable to lose weight, this episode is for you. In this episode of The Thyroid Answers Podcast, Dr. Eric Balcavage explores one of the most misunderstood concepts in thyroid care: the difference between a thyroid lab value being normal and being appropriate for your physiology. He explains why thyroid lab markers such as TSH, Free T4, Free T3, Reverse T3, and thyroid antibodies are often interpreted too simplistically and why normal lab values do not always mean healthy thyroid function. Dr. Balcavage breaks down how stress physiology, inflammation, immune activity, gut dysfunction, sleep disruption, nutrient deficiencies, and overall physiologic state can influence thyroid hormone production and T4-to-T3 conversion. He also explains why many thyroid patterns may actually represent adaptive responses rather than broken physiology. You'll learn how to interpret thyroid labs within the context of symptoms, health history, inflammatory markers, and overall physiologic state, and why focusing solely on optimizing lab values often fails to restore true health and well-being. Whether you're struggling with persistent hypothyroid symptoms despite normal labs or you're trying to better understand your thyroid physiology, this episode provides a deeper framework for understanding what your thyroid labs may really be telling you. In This Episode, You'll Learn: Why normal labs don't always equal healthy thyroid function How to determine if your thyroid labs are actually appropriate for your physiology The role stress, inflammation, and lifestyle factors play in thyroid hormone regulation Why low T3 and poor conversion may be adaptive responses Why thyroid medication doesn't always resolve symptoms What to focus on beyond lab values to support better thyroid health Resources Mentioned:
I spent years doing two-a-days, eating 1,400 calories, and still not getting results. Now I help women fix what's actually broken. Every episode covers:The real reason your metabolism isn't respondingHow hormones, nervous system, and identity all connectWhat it actually looks like to be fit and still live your lifeSupport the showHosted by Casey Shipp — 3000+ transformations, Self-Made Millionaire, High Priestess, Writer, Fitness Cover Model, and Founder of the Hotbody App.$30M client wins | $7.8M sold onlineRich isn't rare. Category of one is.
In this episode of the PCOS Repair Podcast, you'll explore one of the most misunderstood root causes of PCOS: stress response PCOS. If stress response showed up as your result on the PCOS Root Cause Quiz, or if you've been told stress might be contributing to your symptoms, this episode breaks down what that actually means from a physiological perspective.Rather than being a personality trait or a sign that you're not managing stress well enough, stress response PCOS is driven by how your nervous system and cortisol signaling respond to the environment around you. Understanding this root cause can transform how you approach healing your hormones, restoring ovulation, and supporting fertility.What Stress Response PCOS Really MeansIn this episode, you'll learn how stress response PCOS develops when the body becomes stuck in chronic survival mode. When the nervous system continuously interprets signals such as sleep deprivation, blood sugar crashes, over-exercise, under-eating, or a relentless schedule as threats, cortisol levels remain elevated and the body prioritizes survival over reproduction.This survival response can lead to suppressed ovulation, disrupted cycles, stubborn weight retention—especially around the midsection—increased inflammation, and worsening insulin signaling. These symptoms are not signs that your body is failing. Instead, they are protective responses to an environment the body perceives as unsafe.Why “Just Relax” Advice Doesn't Fix Hormonal ImbalanceOne of the biggest misconceptions surrounding stress-related PCOS symptoms is the idea that managing stress simply requires meditation or relaxation techniques. In reality, stress response PCOS is driven by physiological inputs, not just mindset.This episode explains why practices like meditation or therapy can be helpful for emotional wellbeing but may not resolve PCOS symptoms if the body continues to receive stress signals such as inconsistent sleep, skipped meals, excessive high-intensity exercise, or chronic under-fueling. When these physical inputs remain unchanged, the nervous system stays activated and hormone balance remains difficult to restore.Stress Response PCOS and Fertility ChallengesFor women who are trying to conceive, stress response PCOS can play a major role in cycle irregularity and difficulty ovulating. This episode explores why medications such as progesterone, clomiphene, or letrozole sometimes fail to produce consistent ovulation when the body is still operating in survival mode.You'll hear how restoring the body's foundation—through consistent sleep, stable blood sugar, proper nourishment, supportive movement, and built-in recovery time—can help shift the nervous system out of chronic stress activation. Once these signals change, the body often becomes far more responsive to both natural fertility and medical treatments.Your Body Is Protecting You, Not Working Against YouOne of the most important takeaways from this episode is a shift in perspective. Stress response PCOS does not mean your body is broken or resisting your efforts. Instead, your body is responding exactly as it was designed to, protecting you during times when it perceives resources to be limited or conditions to be unsafe for reproduction.When the environment begins to signal safety through adequate nourishment, predictable sleep, balanced movement, and recovery, the body can move out of survival mode and begin healing.Discover Your PCOS Root CauseIf you're unsure whether stress response is your primary PCOS driver, the PCOS Root Cause Quiz can help identify the patterns behind your symptoms. This quick assessment provides insight into the hormonal signals influencing your PCOS and helps guide your next steps toward personalized care.The quiz is linked in the show notes and takes just a few minutes to complete.You can take the quiz to discover your root cause hereLet's continue the conversation on Instagram! What did you find helpful in this episode and what follow-up questions do you have?The full list of Resources & References Mentioned can be found on the Episode webpage at:https://nourishedtohealthy.com/ep-185
What if the anxiety, brain fog, cravings, and inflammation you're trying to fix didn't start in your brain, hormones, or immune system — but in the trillions of bacteria living inside your gut? In this episode, Dr. Josh Axe reveals the hidden chain reaction that can begin with low fiber, antibiotics, stress, and ultra-processed food — and may end in leaky gut, poor nutrient absorption, mood issues, obesity, autoimmune disease, and chronic inflammation. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! → http://mybloodwork.com Download the FREE Gut Healing Guide: https://bit.ly/draxegutreset Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1
Leave an Amazon Rating or Review for my New York Times Bestselling book, Make Money Easy! Check out the full episode: https://greatness.lnk.to/1783DM Danny Morel says your suffering didn't start with a bad relationship or a career setback. It started the day you were born. The moment you left the womb, fear entered. Your parents' unresolved pain, the arguments, the stress, the silence, was already imprinting into your subconscious before you could walk or talk. By age seven, you had written the story: I'm not enough. I can't be me. I can't speak my truth. Danny's own mom lost her mother at 13 days old. His father was disowned and couldn't finish a sentence without stuttering. Both passed their wounds down without ever knowing it. Lewis admits his own voice was locked for over 30 years. Healing starts here. Not with the symptoms. With the root. Sign up for the Greatness newsletter: http://www.greatness.com/newsletter Topics childhood trauma, subconscious beliefs, fear of not being enough, parental imprinting, inner child healing, generational trauma, emotional wounds, masculine and feminine wounds, self-worth, voice suppression Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
If you've been doing everything right and still not getting better, this episode was made for you.Dr. Stephanie Canestraro sits down with her colleague and friend, Dr. Christine Schaffner, a naturopathic doctor, bioregulatory medicine expert, and founder of the Sensitive Stack. She has spent her career on the cutting edge of what it actually takes to heal the patients who fall through every crack in conventional and even functional medicine.At the center of this conversation is a concept that changes everything: sensitivity is a symptom, not a diagnosis. The rising epidemic of mast cell activation syndrome (MCAS), histamine intolerance, long COVID, and chronic multisystem illness isn't happening in a vacuum. It's a signal from the terrain, the extracellular matrix, the autonomic nervous system, the fascia, that the body's innate intelligence has been blocked. Dr. Christine explains the foundational principles of bioregulatory medicine, which emerged from Switzerland, Austria, and Germany, and why its approach to regulation, terrain theory, and interference fields offers a roadmap that functional medicine alone often misses.One of the most overlooked and most impactful areas they cover is the dental connection. Root canals, amalgam fillings, cavitations, and hidden jaw infections are among the most common interference fields Dr. Christine sees in chronically ill patients. A dead tooth is a chronic infection, and that infection has direct access to the vagus nerve, the lymphatic system, and the organ meridians mapped on the dental chart. Dr. Stephanie shares her own experience supporting a close family member who went from severe anxiety and heart palpitations to calm and functional — simply by removing one infected root canal. Both doctors discuss how to approach dental interventions safely, why preparation and the right biological dentist matter, and how to mitigate the healing response that can follow.The conversation goes deep on hormones, the menstrual cycle, and chronic illness, territory that rarely gets the clinical attention it deserves. Dr. Christine explains what she calls the "luteal phase flare," the week before a woman's period when progesterone drops, prostaglandins rise, and the immune system wakes up to everything it suppressed during the potential implantation window. For women with Lyme disease, mold illness, parasites, or MCAS, this is often the hardest week of the month and it doesn't have to be. They also cover estrogen dominance, beta-glucuronidase, zearalenone (the mold mycotoxin that mimics estrogen), and the liver's central role in hormone metabolism and detoxification.Dr. Christine also shares her own deeply personal journey, navigating a lawsuit, rebuilding her practice, and facing a diagnosis of a 3.2 centimeter pituitary macroadenoma that required brain surgery. In the two weeks between diagnosis and the operating table, she leaned entirely into energy medicine, coherence healings, meditation, and intention work. Her surgeon later told her he'd be studying her tumor for a long time because for its size, it came out unusually easily. Her story is a testament to what's possible when you apply everything you teach.✦ In this episode:• Bioregulatory medicine explained and why it goes beyond functional medicine• Terrain theory vs. germ theory, and what Louis Pasteur said on his deathbed• The extracellular matrix, lymphatic stagnation, and where disease actually begins• Interference fields: scars, hidden infections, and dental toxicity blocking your healing• Root canals, cavitations, and amalgams as chronic infections connected to your organs• MCAS, histamine intolerance, and why sensitivity is a symptom, not a root cause• The luteal phase flare: why women with chronic illness feel worse before their period• Estrogen dominance, zearalenone mold toxin, and beta-glucuronidase• Long COVID, post-vaccine immune dysregulation, and TH1/TH2 immune imbalance• 5G, EMFs, voltage-gated calcium channels, and cell membrane destabilization• Motherwort, hawthorn, and lemon balm as natural calcium channel stabilizers• Dr. Christine's pituitary tumor diagnosis, brain surgery, and healing journey• The Sensitive Stack: Dr. Christine's new program for sensitive, hard-to-treat patients✦ Find Dr. Christine Schaffner:Website: drchristineschaffner.comThe Sensitive Stack: available at her website and on InstagramInstagram: @drchristineschaffner✦ About Dr. Stephanie Canestraro:Dr. Stephanie is a chiropractor, functional medicine practitioner, and chronic illness survivor. What Happens in Vagus explores root-cause healing through the nervous system, bioregulatory medicine, and the extraordinary intelligence of the human body.Let us know your thoughts on this episode hereFor any further information, feel free to email us at info@vagusclinic.com. Our team is happy to help. We offer 20-minute complimentary health calls, and you can sign up for one here.
What if Parkinson's disease is more than a movement disorder? In this episode, I sit down with Dr. Greg Eckel, naturopathic physician and pioneer in neurodegenerative medicine, to explore a broader, root-cause approach to Parkinson's disease. Inspired by his late wife's battle with Creutzfeldt-Jakob Disease, Dr. Eckel shares the personal journey that led him to dedicate his career to understanding the underlying drivers of neurodegeneration. Together, we discuss the three major contributors he believes are central to neurological decline: environmental toxins, trauma, and infections. We also explore the role of gut health, alpha-synuclein, the vagus nerve, advanced diagnostic testing, personalized medicine, and emerging therapies such as non-thermal low-level laser therapy. This conversation challenges conventional thinking and offers a more comprehensive framework for understanding Parkinson's and supporting long-term brain health. If you're interested in the future of neurodegenerative care, the gut-brain connection, and strategies that go beyond symptom management, this episode is a must-listen. Key takeaways: Three Buckets of Neurodegeneration: The holistic Echo Protocol examines environmental toxins, trauma, and infections as core contributors to Parkinson's and other neurodegenerative diseases. Diagnostic Innovations: Comprehensive diagnostic testing surpasses basic clinical exams by delving into hormonal levels, gut microbiome health, and possible toxic exposures. Holistic Treatments and Protocols: Utilize personalized supplements, dietary modifications, and non-invasive therapies like low-level laser to improve patient outcomes significantly. Innovative Approaches to Parkinson's: Dr. Eckel's Echo Protocol emphasizes neuroinflammation and synucleopathetic disorders, pushing the conversation beyond conventional categorizations. Community and Support: Building supportive communities and encouraging ongoing education empowers patients and practitioners to harness new insights and treatments for neurological conditions. More About Dr. Greg Eckel: Dr. Greg Eckel is a naturopathic physician and Chinese medicine practitioner with more than 25 years of clinical experience and a deep focus on helping the brain do what conventional care often says it cannot: repair, reorganize, and recover capacity. After the death of his wife, Sarieah, from Creutzfeldt-Jakob disease, Dr. Eckel began asking a question that changed the direction of his work: What if the brain's capacity to heal is far greater than the medical system has been willing to acknowledge? That question led him into frequency medicine, quantum biology, mitochondrial metabolism, regenerative therapeutics, and root-cause neurological care. Today, his work spans Parkinson's disease, traumatic brain injury, neurodegeneration, cognitive decline, and normal brain optimization for people who want to protect, sharpen, and extend the function of the brain they rely on every day. He is the founder of bVital in Park City, Utah, the creator of the Eckel Protocol®, and the architect of the Brain Regen program. His clinical model begins by detecting the hidden drivers of dysfunction, correcting the conditions that block recovery, and helping patients build the resilience to thrive for years to come. A speaker, researcher, and author, Dr. Eckel has published peer-reviewed work, trained physicians nationwide, served as past president of the Oregon Board of Naturopathic Medicine, and reached over one million people through summits, webinars, and media appearances. His work continues from one conviction: your brain wants to heal. Sometimes it just needs the right conditions to remember how. Website Instagram Connect with me! Website Instagram Facebook YouTube
Most e-commerce brands pour everything into getting customers to checkout — and then hand them a generic, one-size-fits-all experience that quietly kills the sale. Avi Moskowitz, co-founder of PDQ, has processed millions of checkouts across top Shopify brands (including Jones Road Beauty), and his diagnosis is blunt: cart abandonment isn't a technical problem. It's an emotional one. And it's leaving $270 billion on the table every year.Inside the episode:Why your checkout is the one place segmentation goes to die — and how personalizing it by customer type (first-time, returning, high-value) can drive an 18% AOV lift or double-digit conversion jumpsThe "WISMO problem": why more than 50% of order-related support tickets arrive the same day the order was placed — and what it tells you about the trust gap you're creating at checkoutThe free shipping threshold mistake almost every brand is making (hint: they copied a competitor who also just guessed)Surprising checkout wins from PDQ's testing: why moving the economy shipping option down one slot meaningfully increased revenue per session — without a single new ad or productHow to think about every order as its own P&L — factoring in CAC, COGS, fulfillm—Sponsored by OMG Commerce - go to https://www.omgcommerce.com/contact and request your FREE strategy session today!—Chapters:[00:00] Intro — The $270B checkout abandonment problem[00:22] Welcome & Guest Introduction: Avi Moskowitz, Co-Founder of PDQ[01:52] Avi's Background: From Craft Beer to SaaS Founder[03:23] COVID Timing & The eCommerce Wake-Up Call[05:09] The Root Cause of Cart Abandonment: Trust, Not Technology[07:27] How PDQ Solves the Checkout Confidence Gap[14:30] Reducing Friction: Shipping, Delivery Dates & Upsells[23:00] Free Shipping Thresholds & AOV Optimization[34:00] Building a Checkout That Converts Like Amazon[43:24] Thinking in Mini P&Ls: Per-Order Profit Optimization[46:26] Personalized Checkout Logic at the Customer Level[48:24] Where to Find PDQ & Get Your Free Checkout Audit—Connect With Brett: LinkedIn: https://www.linkedin.com/in/thebrettcurry/ YouTube: https://www.youtube.com/channel/UCQmbMwBW8LYDfFAqNqlgTGw Website: https://www.omgcommerce.com/ Request a Free Strategy Session: https://www.omgcommerce.com/contactRelevant Links: Avi's LinkedIn: /moskowitzaviPast guests on eCommerce Evolution include Ezra Firestone, Steve Chou, Drew Sanocki, Jacques Spitzer, Jeremy Horowitz, Ryan Moran, Sean Frank, Andrew Youderian, Ryan McKenzie, Joseph Wilkins, Cody Wittick, Miki Agrawal, Justin Brooke, Nish Samantray, Kurt Elster, John Parkes, Chris Mercer, Rabah Rahil, Bear Handlon, JC Hite, Frederick Vallaeys, Preston Rutherford, Anthony Mink, Bill D'Allessandro, Stephane Colleu, Jeff Oxford, Bryan Porter and more
Did you know a small sample of hair can reveal what three months of blood tests might miss? In episode 204, I'm sitting down with Dee Davidson, board-certified functional health practitioner and hormone health expert, to talk about the HTMA hair mineral test and why it's one of the most useful tools she uses with her clients. If you have Hashimoto's and you feel like something is still off despite normal labs, this episode is for you. In this episode, you'll learn: Why a blood test gives you a real-time snapshot but the HTMA shows your mineral reserves over three full months What the hair test actually measures, including fight-or-flight status, blood sugar patterns, adrenal load, and hidden stressors How to stop guessing at supplements and start understanding what your body actually needs Hit play and find out what your minerals have been trying to tell you. CONNECT WITH DEE DAVIDSON Website: confidentlyloveyourself.com Instagram: @confidently_love_yourself JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY The Health with Hashimoto's community is on Skool: https://www.skool.com/health-with-hashimotos/about Find all links on my resource page: https://healthwithhashimotos.com/resources/ ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure or prevent any disease.
In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears. Join us as we delve into: •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology. •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly. •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture. •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress. •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end. This episode is for you if: •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work. •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers. •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint. You can also find this episode on… YouTube: https://youtu.be/DygsezbmZxM Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember
The Functional Nurse Podcast - Nursing in Functional Medicine
Sponsored by the Institute for Functional Nursing™. Learn more about our programs at www.fxnursing.com In this episode of the Functional Nurse Podcast, Samantha Hamilton MSN-Ed, RN sits down with Tabetha Hystad RN to discuss her journey from traditional community nursing to functional nursing. After 15 years in healthcare and experiencing the challenges of burnout, pandemic-era healthcare, and personal health struggles, Tabetha began searching for a more holistic and empowering approach to patient care. Her path eventually led her to functional medicine and the Institute for Functional Nursing. Together, they explore how functional nursing principles can be integrated into everyday nursing practice, even in home care and rural healthcare settings. Tabetha shares how she now views patient stories through a root-cause lens, helping clients improve sleep, blood sugar balance, pain management, and overall quality of life through education and lifestyle strategies. She also opens up about her personal experience with fertility challenges, pregnancy loss, women's health concerns, and how functional medicine transformed her perspective on wellness. Whether you're a nurse exploring career possibilities, interested in women's health, or looking for ways to bring functional medicine into your current role, this conversation offers inspiration, practical insights, and hope for what's possible. Connect with Tabetha: Location: Alberta, Canada Profession: Registered Nurse (Home Care & Community Health) Instagram: @rootedprairiewellness
The Power of Functional Medicine: Finding the Root Cause of Chronic Health Problems In this episode of Stay Healthy Knoxville, Dr. John-Mark Chesney sits down with Emily Turner, PA-C, and Randy Martin, PharmD, of Omni Functional Medicine to discuss a different approach to healthcare—one focused on identifying and addressing the root causes of chronic symptoms rather than simply managing them. Together, they explore what functional medicine is, why so many people continue to struggle despite being told their labs are normal, and how factors such as hormones, gut health, stress, metabolism, and inflammation can impact overall health and well-being. Whether you're dealing with fatigue, weight gain, digestive issues, autoimmune disease, chronic pain, or simply aren't feeling your best, this conversation offers valuable insight into how a more personalized approach to healthcare may help uncover missing pieces of the puzzle. In This Episode, You'll Learn: ✅ What functional medicine is and how it differs from traditional healthcare ✅ Why patients can still feel unwell despite "normal" lab results ✅ The importance of looking for root causes instead of just treating symptoms ✅ How hormones, gut health, stress, and metabolism influence overall health ✅ Practical steps you can take to improve your health and energy About Our Guests Emily Turner, PA-C Bachelor's Degree in Dietetics – University of Kentucky Master's in Physician Assistant Studies – Sullivan University Advanced training through The Institute of Functional Medicine Advanced training through The American Academy of Anti-Aging Medicine Randy Martin, PharmD Doctor of Pharmacy – University of Tennessee Co-founder of Omni Functional Medicine Connect with Omni Functional Medicine Instagram: @omnifunctionalmedicine Website: omnifunctionalmedicine.com Enjoying the Podcast? Be sure to subscribe, leave a review, and share this episode with someone who may be searching for answers to ongoing health concerns. Stay healthy, Knoxville!
If you'd like more free help, you can join my free Indestructible Man community, getting free digital copies of my books among other things, by clicking here: https://theindestructibleman.com/
What if your chronic pain, migraines, anxiety, fatigue, IBS, or other persistent symptoms aren't permanent at all? In this fascinating conversation, Dr. Mariza sits down with Dr. Howard Schubiner, physician, researcher, and leading expert in neuroplastic symptoms, to explore a groundbreaking approach that is helping people reverse chronic pain and other conditions long considered lifelong and irreversible. Dr. Schubiner explains how the brain creates pain as a protective danger signal, why emotional injuries can activate the same neural pathways as physical injuries, and how unresolved trauma, chronic stress, adverse childhood experiences, and self-silencing can contribute to chronic symptoms years or even decades later. Together, they discuss the growing body of research around neuroplastic pain, the connection between emotions and physical symptoms, and why many people continue suffering despite normal scans, medications, and conventional treatments. Dr. Mariza also shares her own experience with chronic migraines, leading to a powerful live demonstration of how pain reprocessing techniques can begin shifting the brain's expectations and neural patterns in real time. This conversation offers hope for anyone who has been told they simply need to manage their symptoms for the rest of their life. HOWARD SCHUBINER Dr. Howard Schubiner is a physician, researcher, educator, and one of the leading voices in the field of neuroplastic symptoms. He is the author of Unlearn Your Pain and has spent decades helping patients recover from chronic pain, migraines, fibromyalgia, IBS, anxiety, chronic fatigue, and other conditions through evidence-based approaches rooted in neuroscience, emotional processing, and neuroplasticity. IN THIS EPISODE What neuroplastic symptoms are and why they are often misunderstood How childhood experiences, trauma, and chronic stress can contribute to chronic pain Why migraines, IBS, fibromyalgia, anxiety, and fatigue may share similar brain-based mechanisms The powerful connection between emotions and physical symptoms How pain reprocessing therapy helps retrain the brain's danger signals Why self-silencing and people-pleasing often show up in women with chronic symptoms The role of emotional awareness and expression in healing A live demonstration of changing neural pathways through visualization and safety signals QUOTES“Pain can be a message that our brain sends.” “Emotional injury causes the same parts of the brain to light up as physical injury.” “Chronic pain is not necessarily a life sentence.” RESOURCES MENTIONED Use code ENERGIZED and get 30% off on your first BATCH order http://hellobatch.com/ENERGIZED Get your copy of Dr. Howard Schubiner Newest Book now https://www.amazon.com/Unlearn-Your-Pain-Recovering-Depression/ Unlearn Your Pain Website The Association for the Treatment of Neuroplastic Symptoms (ATNS) Howard Schubiner Instagram Howard Schubiner Facebook RELATED EPISODES 751: Bloating, Brain Fog & Hormone Chaos? Your Gut May Be the Root Cause with Dr. Cassie Smith 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel
When a child is diagnosed with cancer, families are often left searching for answers, support, and hope beyond conventional treatment alone. Yet many parents don't realize there are ways to support the body alongside chemotherapy, radiation, and surgery through personalized nutrition, functional testing, and root-cause health strategies. On today's episode Season Johnson shares her powerful journey from navigating her own son's leukemia diagnosis at age three to becoming a leading practitioner in the pediatric cancer space. She explains how her family's experience inspired her mission to help children and families thrive through and beyond cancer treatment. We discuss the role of functional medicine lab testing, toxin exposure, and personalized health protocols in supporting recovery, reducing side effects, and creating an environment where optimal healing can take place. Season also highlights the importance of hope, human connection, and compassionate care during some of life's most challenging moments. If you'd like to learn how integrative health coaching and functional testing can support families facing cancer while complementing conventional care, tune in to today's Integrative #HealthCoachSuccess episode 441. Enjoy the show, and let us know what you think! - - - Listen or Watch At: IHP.Coach/441 - - - Dr. Cabral's Book, The Rain Barrel Effect: https://amzn.to/2H0W7Ge - - - Become an Integrative Health Practitioner: https://integrativehealthpractitioner.org
Why do so many Catholic young people walk away from the Faith—even after years of religious education? In this episode, Steve Wood uncovers the root cause of faith failure from Matthew 7:21–23: “I never knew you.” Jesus' warning isn't aimed at obvious sinners, but at professing Christians who knew about God yet never truly knew Him. Drawing from Scripture, the Catechism, and insights echoed by Pope Benedict XVI, this episode explains why knowing God is not a notional belief—but a living, transforming relationship. Essential listening for parents, pastors, and anyone concerned about Catholic faith formation, youth apostasy, and passing on a faith that lasts. To obtain your free copy of Steve's new book - visit us at www.rescuingyoungcatholics.com.
What if the foods marketed as “healthy” are actually contributing to the very symptoms so many women are struggling with today? In this eye-opening conversation, Dr. Mariza sits down with Julia Putzeys, certified Nutritional Therapy Practitioner and founder of the Trash Panda app, to expose the hidden reality of ultra-processed foods and how they impact energy, hormones, metabolism, mood, inflammation, and long-term health. Together, they unpack the confusing world of food marketing, ingredient labels, food additives, artificial flavors, seed oils, and the growing prevalence of ultra-processed foods in the modern food supply. Julia shares her own journey from believing she was eating healthy to discovering how many seemingly nutritious products were filled with ingredients that offered little nourishment and often contributed to poor health outcomes. They also discuss the powerful mindset shift from calorie counting and restriction toward nourishment, nutrient density, and real food. As mothers, both Dr. Mariza and Julia share practical strategies for helping children develop a healthier relationship with food while avoiding the traps of hyper-palatable, addictive processed products. If you've ever felt overwhelmed at the grocery store or questioned whether the foods in your pantry are actually supporting your health, this episode offers practical guidance and empowering tools to help you make more informed choices. JULIA PUTZEYS Julia Putzeys is a certified Nutritional Therapy Practitioner, founder of the Trash Panda app, and mother of three. Combining her background in software product management with her passion for nutrition, Julia created Trash Panda to help consumers quickly identify potentially harmful ingredients in packaged foods and discover healthier alternatives. Her mission is to make ingredient transparency and healthier food choices more accessible to families everywhere. IN THIS EPISODE Why over 70% of grocery store products are considered ultra-processed foods The difference between processed foods and ultra-processed foods How food additives, flavorings, and dyes impact cravings, behavior, and long-term health Why calorie counting often distracts us from focusing on true nourishment The connection between ultra-processed foods, inflammation, metabolic dysfunction, and chronic disease How food marketing creates confusion around what is actually healthy Practical strategies for helping children develop healthier eating habits How the Trash Panda app helps consumers identify healthier food swaps QUOTES“Eating whole food means reading the ingredients, not just the nutrition label.” “Your body becomes addicted to ultra-processed foods because they're designed that way.” “When I started focusing on real food, I had so much less food noise.” RESOURCES MENTIONED Use code ENERGIZED and get $10 off on annual membership for the Trash Panda App on IOS https://apps.apple.com/redeem Download the Trash Panda App now on IOS or Android https://trashpanda.app.link/AvwFh7mfG3b Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Trash Panda App Website Trash Panda App Instagram Trash Panda App Facebook Trash Panda App Youtube RELATED EPISODES 751: Bloating, Brain Fog & Hormone Chaos? Your Gut May Be the Root Cause with Dr. Cassie Smith 741:Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause
Want help uncovering the real reasons behind your urges and build a plan to overcome your pornography use? Click here to book a free call with Sam to get help to overcome pornography – https://stopporn.info/ Have questions you want me to address on future podcast episodes? Email me here: sam@healingcouples.org Episode show notes: Why You Can't Stop the Cycle — How to Identify the Root Cause of Pornography Addiction and Finally Break Free Most people trying to overcome pornography addiction focus on the wrong thing. They manage urges in the moment, set up filters, avoid triggers, and white-knuckle their way through temptation — and still end up back in the same cycle. In this episode, we break down why pornography addiction recovery requires more than willpower, and what actually drives compulsive pornography use at the root level. If you're a husband struggling with pornography addiction, a wife recovering from betrayal trauma after discovering your husband's pornography use, or a couple trying to rebuild trust after pornography has damaged your marriage — this episode is for you. You'll learn a practical four-step framework for identifying what's underneath pornography urges before they become a problem. We cover how to recognize emotional triggers versus external triggers, why stress, loneliness, shame, and disconnection fuel pornography addiction, and how to move from surface-level awareness to real resolution. Topics covered in this episode include: how to stop pornography addiction at the root, why pornography urges keep coming back, how betrayal trauma affects wives, how to rebuild trust after pornography addiction, the difference between pornography addiction triggers and opportunities, why willpower doesn't work for pornography recovery, and how couples can heal together after pornography has damaged their marriage. Whether you're just discovering your husband's pornography addiction, deep in the recovery process, or trying to understand why progress keeps stalling — this episode gives you a clear, practical path forward.
Are you still exhausted even though you're doing everything you can for your Hashimoto's? The problem might be something you literally cannot feel. Vitamin D is one of the most common root cause triggers for Hashimoto's, and most women have no idea their levels are low. You cannot feel it when your vitamin D is low. You cannot feel it when it is high. The only way to know is to test. And if your levels are not where they need to be, your immune system is missing one of its most important tools for calming down. In this episode, Esther breaks down why vitamin D is a root cause trigger for Hashimoto's, how it works in your immune system, and what you actually need to know about getting your levels up, whether that is through summer sun exposure or smart supplementation. In this episode, you will learn: Why vitamin D acts like a brake system for your immune system and what happens when those brakes fail What optimal vitamin D levels actually look like and why "not deficient" is not good enough How summer sun exposure works, why it is not as simple as going outside, and what to do about it year round Ready to map out all of your root causes? Hashimoto's Decoded: Root Causes Revealed walks you through the whole picture in under an hour, with a workbook to help you figure out your next step. https://healthwithhashimotos.com/hashimotos-decoded/ RELATED EPISODES: #9: Vitamin D and Autoimmune Disease #62: How to pick a vitamin D supplement JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Unlock your wellness journey with the free Health with Hashimoto's community! Join a supportive community that's here for you every step of the way. The Health with Hashimoto's community is on Skool: https://www.skool.com/health-with-hashimotos/about Find all links on my resource page: https://healthwithhashimotos.com/resources/ ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure or prevent any disease.
“What if your bloating, fatigue, brain fog, anxiety, stubborn weight gain, and hormone symptoms are actually starting in your gut?” In this episode, Dr. Mariza sits down with Dr. Cassie Smith — dual board-certified endocrinologist, founder of Modern Endocrine, and author of Fix Your Gut, Fix Your Hormones — to unpack the powerful connection between gut health, hormone balance, stress, metabolism, inflammation, and reproductive health. Together, they dive into how chronic stress, poor gut health, blood sugar dysregulation, inflammation, and lifestyle overload silently impact everything from cortisol and insulin to estrogen, progesterone, thyroid function, and fertility. Dr. Cassie explains why so many women are told their labs are “normal” while still feeling exhausted, bloated, anxious, inflamed, and disconnected from their bodies — and why gut dysfunction is often the missing piece conventional medicine overlooks. They also explore the growing metabolic and hormonal crisis happening in younger women, the connection between PCOS, insulin resistance, gut dysfunction, and birth control, and why many women are struggling to restore healthy cycles and fertility later in life. This conversation is a powerful reminder that hormones do not work in isolation. Your gut, nervous system, metabolism, sleep, stress resilience, and hormones are all deeply interconnected. If you've been feeling like your body is trying to tell you something but nobody has connected the dots yet, this episode will help you understand where healing truly begins. DR. CASSIE SMITH Dr. Cassie Smith is a dual board-certified endocrinologist and the founder of Modern Endocrine. After becoming frustrated with the limitations of conventional medicine, she built a practice focused on uncovering the root causes behind hormone dysfunction, metabolic issues, fertility struggles, and gut-related symptoms. She is also the author of the book Fix Your Gut, Fix Your Hormones. IN THIS EPISODE Why chronic stress has such a powerful impact on gut health and hormones How gut dysfunction contributes to fatigue, brain fog, bloating, anxiety, and weight resistance The connection between estrogen decline, microbiome diversity, and inflammation Why insulin resistance and metabolic dysfunction are rising in younger women The hidden relationship between PCOS, gut health, cortisol, and fertility Why birth control is often used as a Band-Aid instead of addressing root causes The foundational lifestyle habits that support gut and hormone healing Why slowing down, resting, and reducing nervous system overload matters for recovery QUOTES “Your hormones are doing the best they can in the environment you give them.” “It doesn't matter how many supplements or hormones we throw at you if the foundations aren't in place.” “Your gut is where all healing begins.” “Your body cannot heal in survival mode.” RESOURCES MENTIONED Get your “Fix Your Gut, Fix Your Hormones” Book by Dr. Cassie Smith https://guthormonefix.com/ Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Modern Endocrine Website Modern Endocrine Instagram Modern Endocrine Facebook Modern Endocrine Tiktok Modern Endocrine Youtube Hormones, Metabolism and You PodcastThe Menopause Gut Book by Cynthia Thurlow RELATED EPISODES 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan 738: The Hidden Link Between Inflammation, Hormones & Fertility with Dr. Natalie Crawford 740: Why You're Bloated, Gaining Weight & Feeling Off in Menopause (It Starts in Your Gut) with Cynthia Thurlow
Saifedean presents the Misesian case against Israel, and argues the only way to understand the Palestinian/Israeli conflict is that it is the result of the denial of property rights for Palestinians based purely on their not belonging to the ruling ethnoreligious group.Full Article: https://saifedean.substack.com/p/property-rights-the-root-cause-ofArticle on X: https://x.com/saifedean/status/1987845360484520258
Send us Fan MailMany women are doing everything "right."They're eating healthy, taking supplements, exercising, seeing specialists, getting labs done… and yet they still feel exhausted, inflamed, anxious, hormonally imbalanced, unable to lose weight, struggling with sleep, gut issues, thyroid symptoms, autoimmune conditions, or fertility challenges.So what if the problem isn't a lack of effort?What if the real issue is happening further upstream?In this fascinating episode of The It's Hertime Podcast, Cody sits down with Deborah Maragopoulos, FNP—better known as "The Hormone Queen"—to discuss the powerful role of the hypothalamus, a small but critical part of the brain that helps regulate hormones, metabolism, sleep, digestion, stress response, immunity, fertility, body temperature, and much more.Drawing from more than 30 years of clinical experience working with complex chronic illness cases, Deborah explains why so many women feel dismissed, why normal labs don't always mean optimal health, and why addressing symptoms alone often fails to create lasting healing.Together, Cody and Deborah explore the connection between stress, the nervous system, thyroid function, gut health, autoimmunity, metabolism, and hormone balance—and what women can do to support the body's communication systems naturally.If you've ever felt like you've tried everything and still don't feel like yourself, this conversation may connect some important dots.In this episode, we discuss:• What the hypothalamus is and why it matters • Why women can feel terrible despite "normal" lab results • The connection between stress and hormone signaling • How nervous system overload impacts metabolism and health • Why thyroid symptoms persist for some women even on medication • The relationship between gut health, inflammation, and hormones • Hashimoto's, autoimmune disease, and chronic stress patterns • Weight loss resistance, fatigue, brain fog, anxiety, and sleep disruption • Why so many women feel stuck despite doing all the right things • Practical ways to support the body's communication systems naturallyConnect with Deborah Maragopoulos:Instagram: @deborahmaragopoulosfnp https://www.instagram.com/deborahmaragopoulosfnp/YouTube: https://www.youtube.com/channel/UCTwDjUWkxsANSmh2wF5ltSgWebsite: https://genesisgold.comFree Gift for It's Hertime Listeners: https://thehormonequeen.com/hertimeConnect with Cody:Instagram: https://www.instagram.com/codyjeansanders/Mixhers: Use Code: Cody for 15% offIf this episode helped you, please subscribe, leave a review, and share it with a friend who needs to hear it. Your support helps us reach more women with empowering health education.Did you learn something new today? Be sure to subscribe to this podcast and share this episode with all the girls you love. We would appreciate it if you'd also leave us a rating and review on iTunes.Want to join our Mixhers Girl community and keep this conversation going? We'd love to hear your thoughts, feelings and experiences! Join us HERE!Join Mixhers email list and be the first to have access to new products and be the girl in the know!Follow Cody Instagram:@codyjeansanders
Many people with hypothyroidism or Hashimoto's are surprised when they begin experiencing symptoms like bloating, constipation, food sensitivities, gallstones, fat intolerance, reflux, or elevated cholesterol. These issues are often treated as separate conditions, but they may all be connected through one important physiological relationship: the connection between thyroid function, bile flow, gallbladder health, and digestion. In this episode, Dr. Eric Balcavage explains why thyroid physiology influences far more than metabolism. Thyroid hormone signaling affects stomach acid production, digestive enzymes, gut motility, bile production, gallbladder contraction, cholesterol metabolism, microbiome balance, nutrient absorption, and even the integrity of the gut barrier. When thyroid physiology is altered, digestive function often changes along with it. Dr. Balcavage explores the critical role bile plays in digestion and overall health, including how bile acids function as powerful signaling molecules that influence metabolism, inflammation, blood sugar regulation, thyroid hormone activation, microbiome health, and immune function. He also explains why reduced T4-to-T3 conversion can impair bile production, gallbladder emptying, and bile delivery into the small intestine, creating a cascade of digestive and metabolic symptoms. You'll learn why digestive symptoms, gallbladder problems, dysbiosis, leaky gut, and elevated cholesterol are often downstream effects of chronic stress physiology and reduced thyroid signaling rather than isolated problems. Dr. Balcavage also discusses common bile-support strategies including ox bile, TUDCA, phosphatidylcholine, taurine, glycine, choline, magnesium, and bitters, explaining when they may be helpful and why they often serve as temporary management tools rather than long-term solutions. Most importantly, this episode highlights why addressing the underlying causes of reduced thyroid signaling and chronic physiologic strain is essential for lasting recovery. In This Episode, You'll Learn: Why people with thyroid problems commonly develop gut, bile, and gallbladder issues The important role bile plays beyond fat digestion How bile acids influence metabolism, inflammation, microbiome balance, and thyroid hormone activation Why reduced T4-to-T3 conversion can impair bile production and bile flow The connection between hypothyroidism, elevated cholesterol, and gallbladder dysfunction How altered bile flow contributes to bloating, constipation, food sensitivities, dysbiosis, and leaky gut Why digestive symptoms are often adaptive responses to physiologic stress The relationship between chronic stress, reduced thyroid signaling, and digestive dysfunction When bile-support supplements like ox bile, TUDCA, taurine, glycine, choline, and phosphatidylcholine may be beneficial Why symptom management alone often fails to create long-term improvement The key factors that may be driving reduced thyroid signaling and digestive dysfunction beneath the surface Resources Mentioned:
Have you ever found yourself trapped on one extreme of the healing spectrum? On one side, there's spiritual bypassing—blaming every flare-up, bout of stubborn acne, or painful period exclusively on Mercury retrograde, a heavy full moon, or a deep soul ascension while ignoring what your 3D body actually needs. On the flip side, there's over-physicalizing—pounding endless physical protocols, obsessing over restrictive diets, and practitioner-hopping, all while running away from the trauma or grief that lives deep in your belly. In this episode, Dr. Jen White breaks down the ultimate truth of holistic medicine: you are a soul residing in a physical meat suit, and your symptoms are almost always both physical and energetic. Dr. Jen shares her own mystical experiences from a recent priestess retreat—where she witnessed profound physical healings through the sacred art of anointing and plant allies—and drops her signature "Root Check Framework" to help you discern exactly what your body is trying to communicate. Whether your body is asking for progesterone or prayer (or a beautiful combination of both!), it's time to let go of perfectionism and step into true integration. Themes: Recognizing the two extremes of spiritual bypassing versus over-physicalizing your health journey. Dr. Jen's experiences at the Rosa Mystica Mystery School and the therapeutic power of high-frequency essential oils (featuring Diana Dubrow's Emerald Temple). A master discernment checklist to identify whether a symptom is primarily rooted in your biochemistry or your energetic field. Analyzing specific health examples, including sprained wrists, severe period cramps, anxiety, depression, and sudden acne flare-ups. Why catching a virus or feeling physically down can actually be an energetic recalibration and a spiritual upgrade. How functional mushrooms can help reprogram neural networks and clear stagnant energy so the physical body can heal. Connect with Jen:
Matt Oh was an engineer with a stable career and a 9-to-5 when a mission trip to India stopped him in his tracks. He saw something he couldn't unsee — women and children spending 10 hours a day walking to collect dirty water.In 2015, he founded FOREFRONT Charity with a few college friends and one water well. Today, more than 100,000 people across India, Kenya, and East Africa have been impacted through clean water, education, medical care, and empowerment. 105 water wells drilled. A school built, in which 20% of the students once worked in child labor, that now serves more than 250 first-generation students. A 90% program efficiency rate. Clearly, an engineer is running this.
Today on The Cosmic Womb: The four pillars of fertility: reveal, remove, rebalance, receiveThe importance of understanding root causes of infertilityImpact of stress and energetic states on fertilityLifestyle factors affecting reproductive healthThe role of diet, sleep, and toxins in fertilityConnect with Dr. AumatmaIGWebsiteFertility Secrets Ted TalkConnect with Emily: IG: @emilythemediumWebsite: emilythemedium.com Fertility Initiation Virtual Retreat Sign UpSpirit Baby Q+A Temple Tickets Available June 30th 1PM ESTOther Resources:Use code EMILY10 to shop MILKMOON Fertility and Postpartum tonics https://bit.ly/3uoNYsn
How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
This episode was sponsored by Cardiff & Energized Health LightSpeed VT: https://www.lightspeedvt.com/ Dropping Bombs Podcast: https://www.droppingbombs.com/ Today's Dropping Bombs episode features John Jubilee — health researcher and creator of the 88-Day Protocol who, at 65 years old, just set a world record bench pressing 555 pounds 14 times. He's spent 29 years measuring over 50,000 people, and in all that time, hasn't even found five who were properly hydrated. John breaks down why drinking more water isn't solving anything, why cellular dehydration is the root cause of virtually every illness and disease (from Lyme and Crohn's to ED, low testosterone, joint degeneration, and hormone imbalances), and the simple protocol that's reversing what doctors call irreversible. If you're tired of being told to manage your symptoms and ready to actually fix the root cause, this is the episode you've been waiting for.
© 2020-2026 Ivy Podcast Discovery LLC
