Podcast appearances and mentions of John Gurdon

Our guests in this episode have been described as the world's two oldest scientifically astute longevity activists. They are Kenneth Scott, aged 82, who is based in Florida, and Helga Sands, aged 86, who lives in London.David has met both of them several times at a number of longevity events, and they always impress him, not only with their vitality and good health, but also with the level of knowledge and intelligence they apply to the question of which treatments are the best, for them personally and for others, to help keep people young and vibrant.Selected follow-ups:Waiting For God - 1990s BBC ComedyAdelle Davis, NutritionistRoger J. Williams, BiochemistThe Importance of Maintaining a Low Omega-6/Omega-3 RatioLife Extension MagazineCalifornia Age Management InstituteFibrinogen and agingProfessor Angus Dalgleish, Nuffield HealthAbout Aubrey de Grey speaking at the Royal InstitutionGeorge Church, GeneticistJames Kirkland, Mayo ClinicDaniel Munoz-Espin, CambridgeNobel Prize for John Gurdon and Shinya YamanakaVSELs and S.O.N.G. laserXtend Optimal HealthFollistatin gene therapy, MinicircleExosomes vs Stem CellsPrevent and Reverse Heart Disease - book by Caldwell Esselstyn Jr Dasatinib and Quercetin (senolytics)We reverse atherosclerosis - Repair BiotechnologiesBioreactor-Grown Mitochondria - MitrixNobel Winner Shinya Yamanaka: Cell Therapy Is ‘Very Promising' For Cancer, Parkison's, MoreDeath of the world's oldest man, 25th Nov 2024Blueprint protocol - Bryan JohnsonMusic: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

Prof. Magdalena Zernicka-Goetz directs research labs at both CalTech in the US and the University of Cambridge in England. Magdalena is one of the world's leading developmental biologists, who has been recognized by the 2023 Ogawa-Yamanaka Stem Cell Prize and Science magazin's People's Vote for Scientific Breakthrough of the Year in 2016. In this episode, we explore the relationship between art and science, and discuss how emotions act as a catalyst for creativity. Magdalena reveals that most of the work in her lab starts without a very detailed plan, which leaves everyone open to embrace unexpected observations. Knowing how to invoke lateral thinking helps to find creative ways out of a problem in a time of crisis. Magdalena also talks about her collaboration with John Gurdon, with its complementary sides of rigor and inspiration. ​​For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Welcome to Living Well with MS, where we are pleased to welcome Dr Stefano Pluchino as our guest! Dr Pluchino is a Professor of Regenerative Neuroimmunology at Cambridge University and has been researching stem cell therapy for progressive MS. In this episode, Dr Pluchino speaks to Geoff about what advanced cell therapy is, the success of his phase one trial and what the future of DMTs looks like indicating what people with MS may experience. Watch this episode on YouTube here. Keep reading for the key episode takeaways. Topics and Timestamps: 01:31 Dr Pluchino's background and research into stem cell therapy for progressive MS. 02:52 The difference between types of MS. 05:09 Navigating DMT options for progressive MS. 08:40 Dr Pluchino's advanced cell therapy research trial: The success of phase one and plans for phase two. 21:05 How advanced cell therapy compares to HSCT or bone marrow transplants. 26:02 What it means for the future of DMTs. 33:39 How you can be part of groundbreaking MS research and trials. Selected Key Takeaways: There are nuances in types of MS beyond ‘relapsing' or ‘progressive'. 04:23 "It is becoming more complex between active and non-active types of primary and secondary progressive MS where activity is attributed to other episodes. Clinical episodes of disease or radiologically evident episodes of disease, which can be identified by the use of contrast agents at the time of the MRI. So, they are very complex very heterogenous types of disease, with or without activity, which inevitably undergo accumulation of neurological deficits.” The next generation of DMTs will target progression rather than relapses. 06:39 “What's becoming very interesting is that [over the last] few years, there is a general worldwide consensus that progressive MS is becoming and has become a clinical unmet need. The old MS world is concentrating on financing, funding and efforts towards stopping MS through the development of a new generation of DMDs which will eventually target progression rather than relapses.” The future of advanced cell therapy research will look at remyelination, reduction of inflammation and neuroprotection. 19:10 "There is space for assessing whether a proportion of the injected cells [can] differentiate in vivo into new myelin-forming cells. There is a space to assess whether some of the cells [can] increase the survival of neurons in the brain. There is space to assess whether the transplanted cells [can] reduce the type of inflammation which characterises progressive MS, which is what we call a smouldering inflammation. These highly diffuse homogeneous, low-level activations of microglia (immune cells of the central nervous system) and astrocytes (star-shaped cells that hold nerve cells in place) might be reduced by means of advanced cell therapy and the reason why I am specifically alluding to these three major biological mechanisms of disease, remyelination, reduction of inflammation and neuroprotection is because we have managed to identify each of these mechanisms in clinically relevant animal disease models in the last 25 years. So, there is [an] expectation that a clinical trial designed in a way that will allow us to establish the efficacy of the treatment will reveal what we have established already in one of these models.” Want to learn more about living a full and happy life with multiple sclerosis? Sign up to our newsletter to hear our latest tips. More info and links: Video on Early-stage stem cell therapy trial shows promise for treating progressive MS Dr Pluchino's website Dr Pluchino's bio If you have progressive MS you may be eligible for the Octopus trial Learn about HSCT from Professor Richard Burt in Season 5 Episode 25 Read about the Shinya Yamanaka  and John Gurdon'a Nobel Winning iPSC technology Find out more about the latest research in progressive MS from the International Progressive MS Alliance New to Overcoming MS? Visit our introductory page  Connect with others following Overcoming MS on the Live Well Hub Visit the Overcoming MS website Follow us on social media: Facebook Instagram YouTube Pinterest Don't miss out:  Subscribe to this podcast and never miss an episode. Listen to our archive of Living Well with MS episodes here. If you like Living Well with MS, please leave a 5-star review. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. Support us:  If you enjoy this podcast and want to support the ongoing work of Overcoming MS, we would really appreciate it if you could leave a donation here. Every donation, however small, helps us to share the podcast with more people on how to live well with MS.

To achieve growth in life, it's crucial to recognize that adhering to the same old routines and approaches won't yield the transformative progress we desire. Whether it's striving for groundbreaking discoveries or aiming to attain the pinnacle of success, following the crowd won't set us apart. Consider scientists as a prime example. While the world is teeming with brilliant minds, it's those who dare to break free from convention and embrace unorthodox thinking who truly leave their mark. Take, for instance, John Gurdon, the British developmental biologist whose early academic struggles didn't deter him from making groundbreaking contributions to cloning and stem cell research, ultimately establishing himself as a luminary in the field of biology. Similarly, Srinivasa Ramanujan, the self-taught Indian mathematician, astounded the world with his remarkable contributions to number theory, mathematical analysis, and continued fractions. Even iconic figures like Einstein and Newton transcended the confines of traditional learning, demonstrating that progress demands a departure from one-dimensional, textbook approaches. To achieve personal growth and ascend to new levels in our lives, we must acknowledge that we, too, must evolve. Today, we're going to have a multidimensional, expansive conversation with two people I adore and love, Monique Garsaud and Donna DiDomenico, to discuss the concept of "Next Level Living." We'll explore how becoming more aware of ourselves and our surroundings can lead to a more fulfilling life. We will cover personal stories, varied careers, and the paths they've taken to break free from societal expectations. Join us in this deep conversation about personal growth, finding yourself, and creating a more meaningful life. Feel free to connect with Donna DiDomenico at donna@bthedifference.global and for a deeper dive into Monique Garsaud's world, explore her website at https://www.moniquegarsaud.com/. They're just a click away from sharing their incredible insights and experiences with you! I help important people turn their dull lives into exciting experiences that touch their hearts and souls. If you are ready to get out-of-the-box of your life, engage intuitive tools, and elevate your life and business, then Next Level Living is for you. You are ready to bring your mission to the world. Whether you are speaking on stages, creating your signature product, healing the masses, writing a book, producing your film, or all of the above, book a call with me. You have nothing to lose but time, and you already watch that pass you by daily. Next Level Living— go to  www.marilynalauria.com/next. I've got something special for you—a FREE training video that introduces you to your Higher Self, the one already living the life of your dreams!  Together, we'll: Expand Consciousness: Embrace new awareness and hidden potentials. Connect to Soul: Ignite purpose by uncovering your true essence. Transcend Ego: Release limiting beliefs holding you back.  Anchor Your Purpose: Unveil your unique life mission. Trust Intuition: Embrace inner guidance and self-trust. Decisions with Wisdom: Make life-changing choices guided by your Higher Self. Don't wait. Your journey begins now. Grab your FREE training now: https://www.marilynalauria.com/higherself/   In this episode you'll learn about: Thinking beyond one-dimensional approach What is power? The role of personal responsibility in transformation 16:38 - for the person that's lost and no idea what to do next 24:16 - living a normal life with your gifts 29:24 - seeing things as expansive beyond the 3D 39:14 - growing your gifts beyond belief systems 48:29 - being your own instrument 1:07:15 - final thoughts and questions to get you thinking   Related Episodes: Eps 144 – Monique Garsaud – Endless Expansion Eps 128 – How to Step Into and Own Your Greatness Eps 112 – Tapping Your Way to Alignment with Dana Middleton   Don't forget new episodes come out every Thursday! Follow and rate the podcast on Apple Podcast. Help us spread the word by sharing this episode with a friend.   If you have questions, email info@MarilynAlauria.com. Meet your own personal Guide at  https://marilynalauria.com/guide. _______________________________ Follow me on social: Facebook  Instagram LinkedIn

春の訪れ、Daylight saving time、ペッパーランチの思い出、マリトッツォって何、磁力を使って生きた細胞の中のクロマチンを動かす論文、種間で寿命のばらつきが非常に大きい(11-200歳)根魚のゲノム解析論文について話しました。Shownotes Daylight saving time … いわゆるサマータイム ソメイヨシノ … ソメイヨシノ研究といえば遺伝研の竹中要先生。 Daylight saving timeを一年中使うことの議論 ペッパーランチ 超高級食材でペッパーランチ作ったら美味すぎて言葉を失いました… (by ヒカキン) … 飯テロ許すまじ！ Pepper Lunch in Vancouver Yoshinoya Yayoi BOSSO … Harvard Buisiness Schoolを卒業した人が始めたラーメン屋さん。唐揚げが一番おいしかった。 mochi doughnuts & Taiyaki … ポンデリング系ドーナッツ(mochi doughnuts)とタイ焼きの口からアイスが突っ込まれているタイ焼きアイスクリームのヒットについてはまた話したい。 Tsurumen davis … Researchat.fm ep5で登場した1000日しか営業しないラーメン屋さん。ついに1000日を迎え、営業を終えた（らしい） マリトッツォ … 名前だけ聞いたことがある伝説上の食べ物 BOOK OFF NY Keizer et al. bioRxiv (2021) … “Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics” John Gurdon Egli et al. Nature (2007) … “Developmental reprogramming after chromosome transfer into mitotic mouse zygotes” 体細胞の染色体スワップではなかったです… 光ピンセット(Optical tweezers) 磁気ピンセット(Magnetic tweezers) Atomic Force Microscope (AFM) Tetracycline (Tet) Inducible Expression mCherry Yang and Shah Front. Oncol. (2020) … “Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics” Ferritin パーマロイ … ニッケル鉄の合金 Kolora et al. Science (2021) … “Origins and evolution of extreme life span in Pacific Ocean rockfishes” 根魚 Lu et al., Science (2021) … “Long-lived fish in a big pond” Editorial Notes 今年のカナダは歴史的な降水量で雨ばかりの日々でしたが、先週から1ヶ月遅れでようやく夏が来ました (soh) 時節の話なんかするものだから季節外れの話になってしまいました。タイトルにはTweezersを入れましたが、magnetic tweezersの論文ではないです。Rockfishの寿命論文はオープンアクセスではなかった…すいません。(tadasu)

Premio Nobel 2012 per la medicina, ai tempi del liceo il suo docente di scienze definiva "ridicola" la sua ambizione di diventare uno scienziato. Abbiamo incontrato John Gurdon

Nobelpristagare vill inte se ett Brexit. Veckomagasinet tar också upp ojämlik vård av graviditetsdiabetes, arkeologisk madrassforskning, politisk huvudvärk för klimatavtalet och miljögifter i uttrar. Frågan om Storbritannien ska lämna EU eller stanna kvar avgörs i en folkomröstning nästa vecka. För att hedra palamentsledamoten Joe Cox, som dödades i samband med ett politiskt möte under torsdagen, har båda sidorna ett tillfälligt stopp i kampanjandet.Men innan dess hade kampanjen trappats upp. I helgen skrev 13 Nobelpristagare ett brev i Daily Telegraph för att visa sitt stöd för att Storbritannien stannar kvar i EU. Ett av orosmolnen handlar om att forskningen kan få mindre pengar. Vi får mycket ut av att vara medlemmar i EU. De flesta fördelarna skulle försvinna om vi inte var en del av den gemenskapen, säger 2012 års medicinpristagare John Gurdon.Vi frågar oss hur vanligt det är att nobelpristagare använder sina kända namn för att försöka påverka politiska frågor. Programledare Lena Nordlund

5 yr old Georgia asks how did the cells in her mum's tummy know to make her brain cells? A Nobel Laureate provides the answer! Like this podcast? Please help us by supporting the Naked Scientists

In this video interview with John Gurdon, who was awarded the Nobel Prize in Physiology or Medicine on Monday 8th October, he talks about the research that revolutionised a field, his hopes for the future, and that now legendary school report.

Sir John Gurdon talks to Jim al-Khalili about how coming bottom of the class in science was no barrier to winning this year's Nobel Prize for Physiology or Medicine. We're familiar with Dolly the Sheep but many people find the idea of cloning humans rather disturbing. It seems to cut to the core of who we are; but, scientifically speaking, we are getting closer to a time when cloning people might be possible. John Gurdon gives it fifty years. After a famously bad school report for science, he won the Nobel Prize for cloning a frog, decades before Dolly the Sheep. Here he talks to Jim about his pioneering work on cloning and where it all might lead.

Sir John Gurdon talks to Jim al-Khalili about how coming bottom of the class in science was no barrier to winning this year's Nobel Prize for Physiology or Medicine. We're familiar with Dolly the Sheep but many people find the idea of cloning humans rather disturbing. It seems to cut to the core of who we are; but, scientifically speaking, we are getting closer to a time when cloning people might be possible. John Gurdon gives it fifty years. After a famously bad school report for science, he won the Nobel Prize for cloning a frog, decades before Dolly the Sheep. He talks to Jim al-Khalili about his pioneering work on cloning and where it all might lead.

What does exercise and experience do for the brain? Improving maternal care, the brain networks of impulsive behaviour and the rewards of sharing experiences with friends! Plus turning hair into nerve cells to help beat Alzheimer's and we find out what keeps a Nobel Laureate up all night. Like this podcast? Please help us by supporting the Naked Scientists

What does exercise and experience do for the brain? Improving maternal care, the brain networks of impulsive behaviour and the rewards of sharing experiences with friends! Plus turning hair into nerve cells to help beat Alzheimer's and we find out what keeps a Nobel Laureate up all night. Like this podcast? Please help us by supporting the Naked Scientists

Sir John Gurdon, from Cambridge University, talks to Chris Smith about the set of experiments that resulted in the award on the 2012 Nobel Prize for Physiology and Medicine. Like this podcast? Please help us by supporting the Naked Scientists

Sir John Gurdon, from Cambridge University, talks to Chris Smith about the set of experiments that resulted in the award on the 2012 Nobel Prize for Physiology and Medicine. Like this podcast? Please help us by supporting the Naked Scientists

The 2012 Nobel Prize in Physiology or Medicine was awarded jointly to John B. Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent