Podcasts about Nobel Prize

In nature, enzymes are the catalysts that make much of biology work. They jumpstart chemical reactions that either wouldn't happen, or would happen super slowly. They break down food, build other molecules, extract energy, and more. What if we could harness evolution to engineer designer enzymes that do other specific jobs that benefit us?  Putting that idea into practice changed the game for chemistry, and earned Frances Arnold the Nobel Prize prize in 2018. She called it “directed evolution.” Today, thousands of labs use her methods to coax enzymes into doing things no one ever thought of. She joins Host Flora Lichtman to talk about where she sees this approach going in the future, and the personal evolution that brought her into science. Guest: Dr. Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology in Pasadena, California.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

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In this episode, we ask what happens when economic evolution moves from human speed to machine speed. Fresh from an off-the-record discussion with a Nobel Prize–winning AI pioneer Demis Hassibis, we unpack how AI is reshaping medicine, productivity, profits, and power, and why markets are now rewarding mass layoffs as a sign of progress. From Schumpeter's idea of creative destruction to Jack Dorsey's AI-driven job cuts and the explosion of “buy now, pay later” debt, we trace how AI is intensifying inequality, short-termism, and financial fragility. Is this the next great leap forward, or the beginning of a techno-feudal economy where a small elite extracts value at scale? We explore why equilibrium economics no longer makes sense, why evolution never waits for permission, and whether democracy can keep up with machines that learn faster than society can adapt Hosted on Acast. See acast.com/privacy for more information.

When scientist Edward Bloom demonstrated humanity's first anti-gravity device to the world, a single billiard ball punched through his chest at the speed of light — and the only question that remains is whether the man who aimed it knew exactly what would happen.*No AI Voices Are Used In The Narration Of This Podcast*Take the Weird Darkness Survey: https://take.supersurvey.com/QGZCRXPVSIN THIS EPISODE: “The Billiard Ball” is a science fiction murder mystery short story by author Isaac Asimov, written in September 1966 and first published in the March 1967 issue of “If”. The story is based on a journalist's tale on the events that occurred when an antigravity device was discovered. The story describes the relationship between the creator of the device, billionaire inventor Edward Bloom, and his old college friend James Priss, a Nobel Prize-winning theoretical physicist who discovered the theory on which Bloom's invention is based. Both also happen to be very good pool players.HELPFUL LINKS & RESOURCES…https://WeirdDarkness.com/STORE = Tees, Mugs, Socks, Hoodies, Totes, Hats, Kidswear & Morehttps://WeirdDarkness.com/HOPE = Hope For Depression or Thoughts of Self-Harmhttps://WeirdDarkness.com/NEWSLETTER = In-Depth Articles, Memes, Weird DarkNEWS, Videos & Morehttps://WeirdDarkness.com/AUDIOBOOKS = FREE Audiobooks Narrated By Darren Marlar SOURCES and RESOURCES:“The Billiard Ball” by Isaac Asimov: https://weirddarkness.tiny.us/4a7a9m9a=====(Over time links may become invalid, disappear, or have different content. I always make sure to give authors credit for the material I use whenever possible. If I somehow overlooked doing so for a story, or if a credit is incorrect, please let me know and I will rectify it in these show notes immediately. Some links included above may benefit me financially through qualifying purchases.)= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2026, Weird Darkness.=====Originally aired: July, 2021EPISODE PAGE (includes sources): https://weirddarkness.com/TheBilliardBallABOUT WEIRD DARKNESS: #WeirdDarkness is a true crime and paranormal podcast narrated by professional award-winning voice actor, Darren Marlar. Seven days per week, Weird Darkness focuses on all things strange and macabre such as haunted locations, unsolved mysteries, true ghost stories, supernatural manifestations, urban legends, unsolved or cold cases, conspiracy theories, and more. Weird Darkness has been named one of the “20 Best Storytellers in Podcasting” by Podcast Business Journal. Listeners have described the show as a blend of “Coast to Coast AM”, “The Twilight Zone”, “Unsolved Mysteries”, and “In Search Of”.DISCLAIMER: Stories and content in Weird Darkness can be disturbing for some listeners and intended for mature audiences only. Parental discretion is strongly advised.

A deep dive into one of the most overlooked -- and fascinating -- sides of the 2016 Nobel Prize in Literature winner: Bob Dylan, the filmmaker. While his music and lyrics have been studied endlessly, his work behind (and in front of) the camera remains largely unexplored. No other book has taken this angle, and with Dylan's legend still growing, the audience is more than ready for a bold new take. Bob Dylan as Filmmaker: No Time to Think (McNidder and Grace, 2026), the first book of its kind, opens up exciting new ways to think about the artistry of Bob Dylan. It offers a captivating exploration into movies that, according to Michael, showcase Bob Dylan not just as a subject, but as the primary author. These include Eat the Document--a short, experimental television film shot in 1966 and released in 1972; the sprawling, genre-blurring epic Renaldo and Clara (1978), both directed by Dylan himself; and the darkly surreal Masked and Anonymous (2003), directed by Larry Charles but co-written by and starring Dylan. Bob Dylan as Filmmaker explores what these movies reveal about "how it feels" to be Bob Dylan during three defining eras of his career: the revolutionary 1960s, the introspective 1970s, and the enigmatic early 2000s. Just as crucially, they illuminate Dylan's remarkable instinct for using film not merely as a medium, but as a deeply personal mode of expression. The book also provides an essential survey of Dylan's most recent movie projects, including those by other directors, in which Dylan's influence is less overt but no less powerful. Here, Michael argues that Dylan operates as a kind of "invisible co-author" in Martin Scorsese's Rolling Thunder Revue (2019), where Dylan appears as a slippery, self-mythologizing interviewee; Alma Har'el's haunting Shadow Kingdom (2021), a stylized livestream performance; and James Mangold's A Complete Unknown (2024), the Timothée Chalamet-led biopic shaped in part by Dylan's behind-the-scenes "script approval." Michael Glover Smith is a Chicago-based filmmaker, author and teacher. Michael's most recent movie, Hekla, starring Elizabeth Stam, will have it's festival premiere in early 2026. Michael is also the director of four award-winning feature films, the most recent of which, Relative, stars Wendy Robie (Twin Peaks) and is distributed by Music Box Films. His previous book, Flickering Empire: How Chicago Invented the U.S. Film Industry (co-written with Adam Selzer), was published by Columbia University Press to acclaim in 2015. He has seen Bob Dylan 100 times in concert. Michael on Twitter and Bluesky. Bradley Morgan is a media arts professional in Chicago and author of U2's The Joshua Tree: Planting Roots in Mythic America (Backbeat Books, 2021), Frank Zappa's America (LSU Press, 2025), and U2: Until the End of the World (Gemini Books, 2025). He manages partnerships on behalf of CHIRP Radio 107.1 FM and is the director of its music film festival. Bradley on Facebook and Bluesky. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

A deep dive into one of the most overlooked -- and fascinating -- sides of the 2016 Nobel Prize in Literature winner: Bob Dylan, the filmmaker. While his music and lyrics have been studied endlessly, his work behind (and in front of) the camera remains largely unexplored. No other book has taken this angle, and with Dylan's legend still growing, the audience is more than ready for a bold new take. Bob Dylan as Filmmaker: No Time to Think (McNidder and Grace, 2026), the first book of its kind, opens up exciting new ways to think about the artistry of Bob Dylan. It offers a captivating exploration into movies that, according to Michael, showcase Bob Dylan not just as a subject, but as the primary author. These include Eat the Document--a short, experimental television film shot in 1966 and released in 1972; the sprawling, genre-blurring epic Renaldo and Clara (1978), both directed by Dylan himself; and the darkly surreal Masked and Anonymous (2003), directed by Larry Charles but co-written by and starring Dylan. Bob Dylan as Filmmaker explores what these movies reveal about "how it feels" to be Bob Dylan during three defining eras of his career: the revolutionary 1960s, the introspective 1970s, and the enigmatic early 2000s. Just as crucially, they illuminate Dylan's remarkable instinct for using film not merely as a medium, but as a deeply personal mode of expression. The book also provides an essential survey of Dylan's most recent movie projects, including those by other directors, in which Dylan's influence is less overt but no less powerful. Here, Michael argues that Dylan operates as a kind of "invisible co-author" in Martin Scorsese's Rolling Thunder Revue (2019), where Dylan appears as a slippery, self-mythologizing interviewee; Alma Har'el's haunting Shadow Kingdom (2021), a stylized livestream performance; and James Mangold's A Complete Unknown (2024), the Timothée Chalamet-led biopic shaped in part by Dylan's behind-the-scenes "script approval." Michael Glover Smith is a Chicago-based filmmaker, author and teacher. Michael's most recent movie, Hekla, starring Elizabeth Stam, will have it's festival premiere in early 2026. Michael is also the director of four award-winning feature films, the most recent of which, Relative, stars Wendy Robie (Twin Peaks) and is distributed by Music Box Films. His previous book, Flickering Empire: How Chicago Invented the U.S. Film Industry (co-written with Adam Selzer), was published by Columbia University Press to acclaim in 2015. He has seen Bob Dylan 100 times in concert. Michael on Twitter and Bluesky. Bradley Morgan is a media arts professional in Chicago and author of U2's The Joshua Tree: Planting Roots in Mythic America (Backbeat Books, 2021), Frank Zappa's America (LSU Press, 2025), and U2: Until the End of the World (Gemini Books, 2025). He manages partnerships on behalf of CHIRP Radio 107.1 FM and is the director of its music film festival. Bradley on Facebook and Bluesky. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/film

A deep dive into one of the most overlooked -- and fascinating -- sides of the 2016 Nobel Prize in Literature winner: Bob Dylan, the filmmaker. While his music and lyrics have been studied endlessly, his work behind (and in front of) the camera remains largely unexplored. No other book has taken this angle, and with Dylan's legend still growing, the audience is more than ready for a bold new take. Bob Dylan as Filmmaker: No Time to Think (McNidder and Grace, 2026), the first book of its kind, opens up exciting new ways to think about the artistry of Bob Dylan. It offers a captivating exploration into movies that, according to Michael, showcase Bob Dylan not just as a subject, but as the primary author. These include Eat the Document--a short, experimental television film shot in 1966 and released in 1972; the sprawling, genre-blurring epic Renaldo and Clara (1978), both directed by Dylan himself; and the darkly surreal Masked and Anonymous (2003), directed by Larry Charles but co-written by and starring Dylan. Bob Dylan as Filmmaker explores what these movies reveal about "how it feels" to be Bob Dylan during three defining eras of his career: the revolutionary 1960s, the introspective 1970s, and the enigmatic early 2000s. Just as crucially, they illuminate Dylan's remarkable instinct for using film not merely as a medium, but as a deeply personal mode of expression. The book also provides an essential survey of Dylan's most recent movie projects, including those by other directors, in which Dylan's influence is less overt but no less powerful. Here, Michael argues that Dylan operates as a kind of "invisible co-author" in Martin Scorsese's Rolling Thunder Revue (2019), where Dylan appears as a slippery, self-mythologizing interviewee; Alma Har'el's haunting Shadow Kingdom (2021), a stylized livestream performance; and James Mangold's A Complete Unknown (2024), the Timothée Chalamet-led biopic shaped in part by Dylan's behind-the-scenes "script approval." Michael Glover Smith is a Chicago-based filmmaker, author and teacher. Michael's most recent movie, Hekla, starring Elizabeth Stam, will have it's festival premiere in early 2026. Michael is also the director of four award-winning feature films, the most recent of which, Relative, stars Wendy Robie (Twin Peaks) and is distributed by Music Box Films. His previous book, Flickering Empire: How Chicago Invented the U.S. Film Industry (co-written with Adam Selzer), was published by Columbia University Press to acclaim in 2015. He has seen Bob Dylan 100 times in concert. Michael on Twitter and Bluesky. Bradley Morgan is a media arts professional in Chicago and author of U2's The Joshua Tree: Planting Roots in Mythic America (Backbeat Books, 2021), Frank Zappa's America (LSU Press, 2025), and U2: Until the End of the World (Gemini Books, 2025). He manages partnerships on behalf of CHIRP Radio 107.1 FM and is the director of its music film festival. Bradley on Facebook and Bluesky. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/biography

A deep dive into one of the most overlooked -- and fascinating -- sides of the 2016 Nobel Prize in Literature winner: Bob Dylan, the filmmaker. While his music and lyrics have been studied endlessly, his work behind (and in front of) the camera remains largely unexplored. No other book has taken this angle, and with Dylan's legend still growing, the audience is more than ready for a bold new take. Bob Dylan as Filmmaker: No Time to Think (McNidder and Grace, 2026), the first book of its kind, opens up exciting new ways to think about the artistry of Bob Dylan. It offers a captivating exploration into movies that, according to Michael, showcase Bob Dylan not just as a subject, but as the primary author. These include Eat the Document--a short, experimental television film shot in 1966 and released in 1972; the sprawling, genre-blurring epic Renaldo and Clara (1978), both directed by Dylan himself; and the darkly surreal Masked and Anonymous (2003), directed by Larry Charles but co-written by and starring Dylan. Bob Dylan as Filmmaker explores what these movies reveal about "how it feels" to be Bob Dylan during three defining eras of his career: the revolutionary 1960s, the introspective 1970s, and the enigmatic early 2000s. Just as crucially, they illuminate Dylan's remarkable instinct for using film not merely as a medium, but as a deeply personal mode of expression. The book also provides an essential survey of Dylan's most recent movie projects, including those by other directors, in which Dylan's influence is less overt but no less powerful. Here, Michael argues that Dylan operates as a kind of "invisible co-author" in Martin Scorsese's Rolling Thunder Revue (2019), where Dylan appears as a slippery, self-mythologizing interviewee; Alma Har'el's haunting Shadow Kingdom (2021), a stylized livestream performance; and James Mangold's A Complete Unknown (2024), the Timothée Chalamet-led biopic shaped in part by Dylan's behind-the-scenes "script approval." Michael Glover Smith is a Chicago-based filmmaker, author and teacher. Michael's most recent movie, Hekla, starring Elizabeth Stam, will have it's festival premiere in early 2026. Michael is also the director of four award-winning feature films, the most recent of which, Relative, stars Wendy Robie (Twin Peaks) and is distributed by Music Box Films. His previous book, Flickering Empire: How Chicago Invented the U.S. Film Industry (co-written with Adam Selzer), was published by Columbia University Press to acclaim in 2015. He has seen Bob Dylan 100 times in concert. Michael on Twitter and Bluesky. Bradley Morgan is a media arts professional in Chicago and author of U2's The Joshua Tree: Planting Roots in Mythic America (Backbeat Books, 2021), Frank Zappa's America (LSU Press, 2025), and U2: Until the End of the World (Gemini Books, 2025). He manages partnerships on behalf of CHIRP Radio 107.1 FM and is the director of its music film festival. Bradley on Facebook and Bluesky. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/music

Matt Kaplan is a science correspondent at the Economist and author of the new book I Told You So!: Scientists Who Were Ridiculed, Exiled, and Imprisoned for Being Right in which he shares the stories of researchers—from Darwin to Pasteur to modern Nobel Prize winners—who had to fight for their revolutionary ideas to be accepted. "But Paul…” you might say. "This sounds very interesting, but how does it fit into the conversations here on Reasonably Happy?” Good question! It's because I like contrarians and truth-seekers. I worry about prevailing power structures or narratives that restrict innovation, progress, free markets, and personal liberty, whether those obstacles be bureaucracy, fascism, religion, or political correctness. And perhaps by pondering these historical examples, we'll be less likely to repeat past mistakes. Over the last two decades, Matt has written about everything from paleontology and parasites to virology and viticulture. In addition to the Economist, his writing has appeared in National Geographic,  Nature, and the New York Times. He completed a thesis in Paleontology at Berkeley, and one in science journalism at Imperial College, London. In 2014 he was awarded a Knight Fellowship to study at MIT and Harvard. Born in California, he lives in England.    Please ⁠rate and review⁠ ⁠⁠Reasonably Happy⁠ ⁠HERE⁠⁠  (DO IT!)    Read ⁠Paul's ⁠⁠Substack newsletter⁠⁠⁠ ⁠HERE⁠  Buy Matt's book, I Told You So! here. 

The 1930s prove to be an exceptional decade for research at The General Electric Company. Katharine Burr Blodgett works closely alongside her boss, Irving Langmuir who, in 1932, wins the Nobel Prize for Chemistry. In 1938, Katharine's meticulous experiments with thin film coatings on solid surfaces lead to her most important breakthrough: non-reflecting glass. The General Electric Company's public relations machine kicks into high gear. Katharine becomes an overnight sensation, both in the scientific community and in the press, which dub her discovery “invisible glass.” The assistant to the Nobel Prize winner, long invisible herself, takes center stage.  Learn about your ad choices: dovetail.prx.org/ad-choices

There's a crisis in cosmology when it comes to understanding a little thing like the acceleration of our universe, aka The Hubble Tension. And in this episode, Izzie Clarke and Dr Becky Smethurst are digging into what this is and (trying to) explain the science behind it. A huge thank you to our guests, (Nobel Prize winning-) Professor Adam Riess from John Hopkins University and Professor Silvia Galli from Institut d'Astrophysique de Paris. Join The Supermassive Club for ad-free listening, forum access, and extra content from the team. And email your questions to podcast@ras.ac.uk or follow us on Instagram, @SupermassivePod.The Supermassive Podcast is a Boffin Media production. The producers are Izzie Clarke and Richard Hollingham. Hosted on Acast. See acast.com/privacy for more information.

Episode: 2562 Paul Samuelson and the textbook Economics.  Today, a book that helped educate the world.

In his first visit since to CASBS since his 1996-97 fellowship, UC Berkeley economist David Card lifts the veil behind the innovative empirical work on the labor market effects of immigration, minimum wages, and education that earned him the Nobel Prize in 2021. In conversation with 2024-25 CASBS fellow Dylan Connor, Card also explores issues and questions involving the relationships among geography, social and labor mobility, and wealth inequalities. DAVID CARD: UC Berkeley page | Berkeley economics page | Wikipedia page | Nobel Prize page | Google Scholar page | Berkeley Nobel Prize article |  DYLAN CONNOR: ASU page | Google Scholar page |  Work emerging from David Card's CASBS year "Immigrant Inflows, Native Outflows, and the Local Labor Market Impacts of Higher Immigration," Journal of Labor Economics (2001)"Would Financial Incentives for Leaving Welfare Lead Some People to Stay on Welfare Longer?" NBER Working Paper (1997)"Adapting to Circumstances: The Evolution of Work, School, and Living Arrangements among North American Youth," in Youth Employment and Joblessness in Advanced Countries (Univ. of Chicago Press, 2000)"School Finance Reform, the Distribution of School Spending, and the Distribution of Student Test Scores," Journal of Public Economics (2002)"The More Things Change: Immigrants and the Children of Immigrants in the 1940s, the 1970s, and the 1990s," in Issues in the Economics of Immigration (Univ. of Chicago Press, 2000) Other CASBS fellows mentioned in this episode Orley Ashenfelter (1989-90) Alan B. Krueger (1999-2000) Roberto M. Fernandez (1996-97) Robert D. Putnam (1974-75, 1988-89) Min Zhou (2005-06)   Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford UniversityExplore CASBS: website | Bluesky | X | YouTube |LinkedIn | podcast |latest newsletter | signup | outreach​Human CenteredProducer: Mike Gaetani | Audio engineer & co-producer: Joe Monzel |

"I'm currently incarcerated... Convicted of a crime I didn't even commit! Huh! 'Attempted murder;' now, honestly, what is that? Do they give a Nobel Prize for 'attempted chemistry?' Do they?" - Bob Underdunk Terwilliger Sideshow Bob returns and dabbles in the world of Springfield politics in ways that may remind you of Watergate and the 1988 US presidential election. But when he uses his new mayoral powers against the Simpsons, Bart and Lisa have to team up or else risk living in a motel that probably costs more than six dollars a night.  Our guest: Chris Wade, producer of the Chapo Trap House podcast Support this podcast and get over 200 ad-free bonus episodes by visiting Patreon.com/TalkingSimpsons and becoming a patron! And please follow the official Bluesky and Instagram!

What does the timber rattlesnake have in common with the eastern meadowlark? Or how about the elm-leaved goldenrod and the Green Mountain quillwort?These plant and animal species are all classified as endangered or threatened in Vermont. And right now, local biologists are working to update the state's Wildlife Action Plan. That plan is basically a wildlife-focused conservation blueprint for the state. The team that's been working on it is proposing some changes that could mark a shift in how the state thinks about conservation.Recently I sat down with Dr. Rosalind Renfrew to learn more. She's based in Montpelier as the Wildlife Diversity Program lead for Vermont Fish & Wildlife. We were also joined by Kent McFarland from the Vermont Center for Ecostudies in Norwich.Then;  Marie Curie is a famous name, but even if you know who she is, you might only know the basics of her extraordinary life. Marie Curie was a Polish-French scientist and a pioneer in the study of radioactivity. She was the first woman to win a Nobel Prize, and the first person to win a Nobel twice.Marie Curie is also the subject of a new book by Devon Jersild of Weybridge, Vermont. Devon is a psychotherapist and a writer. She's won a prestigious O. Henry Award for her short story writing, and is the former associate director of the Bread Loaf Writers Conference, associate editor of the New England Review, and a visiting lecturer in English at Middlebury College.

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In this bonus episode, Nobel Prize-winning economist Daron Acemoglu joins Sam to challenge some of the most common assumptions about artificial intelligence's future. Drawing on his book Power and Progress, Daron argues that technology doesn't have a fixed destiny — and that today's choices will determine whether AI boosts workers or simply accelerates automation and inequality. He makes a case for focusing on new tasks that complement human skills, rather than replacing them, and warns that current incentives push AI toward centralization and automation by default. The conversation tackles productivity myths, reliability risks, and why regulation should proactively steer AI toward social good. Read the episode transcript here. Guest bio: Daron Acemoglu is an institute professor at MIT, faculty codirector of the James M. and Cathleen D. Stone Center on Inequality and Shaping the Future of Work, and a research affiliate at MIT's newly established Blueprint Labs. He is an elected fellow of the National Academy of Sciences, American Philosophical Society, the British Academy of Sciences, the Turkish Academy of Sciences, the American Academy of Arts and Sciences, the Econometric Society, the European Economic Association, and the Society of Labor Economists. He is also a member of the Group of Thirty. He has authored six books, including Power and Progress: Our Thousand-Year Struggle Over Technology and Prosperity with Simon Johnson. His work in economics has been recognized around the world, notably with the Nobel Prize in economic sciences, along with co-laureates Johnson and James A. Robinson, in 2024. *Please take our listener survey: ⁠⁠mitsmr.com/podcastsurvey⁠⁠ It's short — we promise! — and all respondents will receive a free MIT SMR article collection, "Maximizing the Value of Generative AI." Me, Myself, and AI is a podcast produced by MIT Sloan Management Review and hosted by Sam Ransbotham. It is engineered by David Lishansky and produced by Allison Ryder. We encourage you to rate and review our show. Your comments may be used in Me, Myself, and AI materials. ME, MYSELF, AND AI® is a federally registered trademark of Massachusetts Institute of Technology. All rights reserved.

Tom Bilyeu and co-host DREW dive headfirst into some of the most pressing and controversial news stories shaking the globe. They kick things off by unpacking the arrest of Prince Andrew—highlighting the unprecedented legal scrutiny on the British royal family and its deep connections to the infamous Epstein saga. The conversation peels back the layers of power, secrecy, and the changing nature of accountability in the age of hyper-velocity information, asking whether true justice can ever be achieved when the world's elites are involved. But the episode doesn't stop there. Tom Bilyeu and DREW pivot to the bizarre timing of President Trump's announcement to “give us the aliens,” raising questions about whether disclosures about extraterrestrial life are just next-level distractions from more uncomfortable truths. From Nobel Prize-winning physics experiments that challenge our understanding of reality itself, to politicians and military personnel testifying under oath about UFOs, this discussion is a whirlwind journey through the places where science fiction meets political theater. As always, expect sharp analysis, biting humor, and a fearless willingness to address the issues others avoid. Whether it's the unraveling of global conspiracies, the fate of democracy in an era of fractured narratives, or the economic chess game of international tariffs, this episode promises to make you think deeper and question everything. Buckle up—this is Impact Theory at its thought-provoking best. Huel: High-Protein Starter Kit 20% off for new customers at https://huel.com/impact code impactKetone IQ: Visit https://ketone.com/IMPACT for 30% OFF your subscription orderQuince: Free shipping and 365-day returns at https://quince.com/impactpodShopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impactPique: 20% off at https://piquelife.com/impact Cape: 33% off your first 6 months with code IMPACT at https://cape.co/impact Plaud: Get 10% off with code TOM10 at https://plaud.ai/tomDuck.Ai: Protect your privacy at https://duck.ai/impactRaycon: 15% off at https://buyraycon.com/impact What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER:  https://tombilyeu.com/zero-to-founder?utm_campaign=Podcast%20Offer&utm_source=podca[%E2%80%A6]d%20end%20of%20show&utm_content=podcast%20ad%20end%20of%20show SCALING a business: see if you qualify here.:  https://tombilyeu.com/call Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here.: https://tombilyeu.com/ ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Prince Andrew arrest, Epstein files, Jeffrey Epstein, misconduct in public office, British royal family, information censorship, aliens, extraterrestrial disclosure, Trump administration, political distraction, royal scandal, government secrets, Virginia Giuffre, sexual abuse allegations, whistleblower testimony, House Oversight Committee, UAP (Unidentified Aerial Phenomena), alien technology, Nobel Prize physics, quantum entanglement, Obama alien remarks, Trump tariffs, Supreme Court ruling, International Emergency Economic Power Act (IEPA), tariff lawsuits, government shutdown, GDP numbers, deregulation, energy prices, U.S. manufacturing jobs Learn more about your ad choices. Visit megaphone.fm/adchoices

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This episode explores the vision of Demis Hassabis, CEO of Google DeepMind and recipient of the 2024 Nobel Prize in Chemistry. Hassabis argues that 2026 marks a pivotal turning point in human history, as we enter what he describes as an “AI Renaissance”—an era whose impact could be ten times greater than the Industrial Revolution, unfolding at ten times the speed. He predicts that Artificial General Intelligence (AGI) could be achieved before 2030, while cautioning that today's AI systems remain in a state of “jagged intelligence,” still lacking robust reasoning and long-term planning capabilities. As the industry enters a phase of consolidation, Hassabis is focused on transforming AI into a scientific engine. Through breakthroughs such as AlphaFold and initiatives like Isomorphic Labs, he aims to reshape drug discovery, while collaborations with the U.S. Department of Energy—such as the “Genesis Project”—seek to accelerate progress in energy innovation. At the core of his vision is the concept of “Radical Abundance.” As AI drives the marginal cost of healthcare and energy toward near zero, society may begin to transition into a post-scarcity era. To navigate this shift, Hassabis proposes new social mechanisms, including a “Global Abundance Dividend,” and emphasizes that AI governance must extend beyond technologists, requiring international cooperation to ensure these technologies benefit all of humanity.本集的內容將帶您深入探索 Google DeepMind 執行長、2024 年諾貝爾化學獎得主 戴米斯·哈薩比斯 (Demis Hassabis) 的遠見。哈薩比斯指出 2026 年是人類歷史的轉折點，我們正進入一個「AI 文藝復興」時代，其影響力將是工業革命的十倍，且發展速度快上十倍。 哈薩比斯預測通用人工智能 (AGI) 可能在 2030 年前實現，但警告現今 AI 仍處於「參差不齊的智能」狀態，必須克服基礎推理與長期規劃的缺陷。隨著行業進入「洗牌期」，他致力於將 AI 轉化為科學引擎，透過 AlphaFold 與 Isomorphic Labs 變革藥物研發，並與美國能源部合作「創世紀任務」以加速能源突破。 他最核心的觀點是 「激進豐饒」(Radical Abundance)：當 AI 讓醫療與能源成本趨近於零，人類將邁向「後稀缺」社會。為應對此轉變，他提出「全球豐饒紅利」等社會機制，並強調 AI 治理不能僅留給技術專家，需透過國際合作確保這項技術能造福全人類。 Powered by Firstory Hosting

In this episode of The Left Hook, host Mark Bland delivers a fiery critique of President Donald Trump's second term, now over a year in. He highlights recent headlines, including the arrest of former Prince Andrew in the UK over Jeffrey Epstein-related misconduct following new file revelations, contrasting it with perceived inaction in the U.S. under Attorney General Pam Bondi and FBI Director Kash Patel. Bland accuses Trump of failing working-class Americans, repeatedly promising but never delivering $2,000 "tariff checks" from revenue, while inflation remains high, rents soar (citing examples around $2,700/month), and taxpayer funds flow elsewhere—like military bonuses. He slams Trump's foreign policy missteps: alienating NATO allies, straining relations with Canada and Mexico, and creating the "Board of Peace" (seemingly a personal alternative to international bodies), where Trump reportedly dozed off during meetings and fixated on Nobel Prize hopes despite mocking Norway. Bland ties in Epstein files mentioning Trump extensively (with allegations of abuse, though unproven), Bannon-Epstein communications plotting against Trump, and global calls for accountability, suggesting presidential immunity won't shield child-related crimes. He contrasts this with Biden-era stability and urges listeners to question Trump's unfulfilled promises amid eroding alliances and domestic struggles. The episode blends sharp political commentary with lighter tangents on shower routines and YouTube's 21st birthday.

President Trump recently nominated Kevin Warsh to be the next Chairman of the Federal Reserve Board.  In October 2022, Kevin spoke on What Happens Next along with my old boss Myron Scholes who was the recipient of the Nobel Prize in Economics.In this episode I include excerpts from that previous meeting as well as an additional interview with John Cochrane who is a Professor of Finance and Economics at Stanford's Graduate School of Business and a Senior Fellow at the Hoover Institute, and he will discuss the challenges that Kevin will face in his new job. Get full access to What Happens Next in 6 Minutes with Larry Bernstein at www.whathappensnextin6minutes.com/subscribe

Two-Time NY Times Bestselling AuthorFrom her own remarkable experiences, Janet created the profoundly impactful Passion Test process. This simple, yet effective process has transformed thousands of lives all over the world and is the basis of the NY Times bestseller she co-authored with Chris Attwood, The Passion Test: The Effortless Path to Discovering Your Life Purpose & Shine Your Light: Powerful Practices for an Extraordinary Life by Janet Bray Attwood and Marci Shimoff .Janet is a living example of what it means to live a passionate, fully engaged life. A celebrated transformational leader, Janet has shared the stage with people like His Holiness the Dalai Lama, Sir Richard Branson, Nobel Prize winner, F.W. deKlerk, Stephen Covey, Jack Canfield, and many others. She is also known as one of the top marketers in America. In 2000, Mark Victor Hansen and Robert G. Allen paid for 40 of the top marketing experts in the country to come to Newport Beach, CA to consult with them on marketing their book, The One Minute Millionaire. Janet was one of the very first they invited. As a result of that meeting, Robert G. Allen and Mark Victor Hansen asked Janet to partner with them in their Enlightened Millionaire Program. Her personal stories of following her passions, of the transformations which people like Chicken Soup for the Soul author Jack Canfield have experienced with The Passion Test, and the practical, simple exercises she takes people through to discover their own passions are a few of the reasons she gets standing ovations wherever she presents. Janet has given hundreds of presentations and taken thousands of people through The Passion Test process,in the U.S., Canada, India, Nepal, and Europe. Janet is also the founder of The Passion Test for Business, The Passion Test for Coaches, The Passion Test for Kids and Teens, The Passion Test for Kids in lockdown, and The Reclaim Your Power program for the homeless. Janet is a golden connector. She has always had the gift of connecting with people, no matter what their status or position. From the influential and powerful, to the rich and famous, to lepers and AIDS patients, to the Saints of India, Nepal, the Philippines and elsewhere—to anyone who is seeking to live their destiny, Janet bonds with every single person, and the stories she shares are inspiring, mind-boggling, uplifting and very real. A co-founder of top online transformational magazine, Healthy Wealthy nWise, Janet has interviewed some of the most successful people in the world about the role of passion in living a fulfilling life. Her guests have included Stephen Covey, Denis Waitley, Robert Kiyosaki, Neale Donald Walsch, Paula Abdul, Director David Lynch, Richard Paul Evans, Barbara DeAngelis, marketing guru Jay Abraham, singer Willie Nelson, Byron Katie, Wayne Dyer, Nobel Prize winner Muhammad Yunus, Tony Robbins, Rhonda Byrne and many others. These live teleconference interviews have attracted listeners from all parts of the globe Janet and Chris are both founding members of that organization whose 100+ members serve over 25 million people in the self-development world. Janet Attwood makes magic happen. Her presentations hold audiences spellbound. Her programs attract people from all over the globe. Through her magnetic charisma she is touching the lives of millions of people around the world. janetattwood.com'© 2026 All Rights Reserved© 2026 Building Abundant Success!!Join Me on ~ iHeart Media @ https://tinyurl.com/iHeartBASSpot Me on Spotify: https://tinyurl.com/yxuy23baAmazon Music ~ https://tinyurl.com/AmzBAS https://tinyurl.com/BASAud

Kate Wolf and Eric Newman are joined by the novelist and critic Namwali Serpell to discuss her latest book, On Morrison. Through close readings of Toni Morrison's many novels, as well as her plays, short stories, and early work as a book editor, Serpell's book appraises how critics, scholars, and the public received Morrison across her career and beyond. The book rigorously examines Morrison's writing from a plenitude of contexts and angles, including Black aesthetics, history, literature, race, gender, philosophy, and craft. Though Morrsion has long been considered a titan of American literature, and was the first Black woman to win the Nobel Prize for literature in 1993, On Morrison proves that there is still plenty more to be gleaned from the complexity and achievement of her work. Serpell discusses what makes Morrison a difficult writer, how she is often misread, and why her books speak, as ever, to the present moment.

Leave it to a Nobel Prize winner to turn out a book that is so charming, rich, funny, complex and sophisticated. I love this book so much. Listen in to hear how this potent mix of melodrama, fiction and memoir keeps me returning to it over and over.

Toni Morrison's work undeniably reshaped American literature, and her influence extended well beyond her novels like Beloved or The Bluest Eye. Morrison confronted slavery, identity, trauma - as well as beauty - as she centered Black experiences. Morrison changed not only what stories were told, but how they were told.rnrnHarvard professor and award-winning author Namwali Serpell's latest book On Morrison, argues that Morrison's literary skill often gets overshadowed by her public image as a Black female writer. On Morrison takes readers through her canon of literature, and focuses on the artistry and technique, demonstrating "how to read Morrison with the seriousness that she deserves."rnrnNamwali Serpell was born in Lusaka and lives in New York. She is the author of multiple award-winning books, and her debut novel, The Old Drift, won an Anisfield-Wolf Book Award, the Arthur C. Clarke Award for Science Fiction, and the Los Angeles Times's Art Seidenbaum Award for First Fiction.rnrnFor an entire year, starting on Toni Morrison's birthday, the influential Nobel Prize-winning Ohioan will be the focus of literary and historic events in the Buckeye State. Join us - in partnership with Literary Cleveland - as Kourtney Morrow with the Anisfield-Wolf Book Awards sits down in conversation with On Morrison author Namwali Serpell.

Dr. Stuart Grant, founder of Archetype Medtech, shares his journey designing and delivering breakthrough orthopedic and surgical innovations across the UK, US, and China. Stuart recounts how an early internship led him into medtech, what kept him there, and how building the ASPAC Innovation Center in China helped accelerate a total knee instrument system that dramatically reduced time to market. He explains the leap from corporate leader to entrepreneur: planning for years, earning a PhD in Medtech Product Innovation, and building a consultancy that helps startups and scale-ups turn early clinical unmet needs into market-ready, regulator-approved devices through a network of experts and an “expertise for equity” model.    Guest links: https://archetype-medtech.com/  Charity supported: Sleep in Heavenly Peace Interested in being a guest on the show or have feedback to share? Email us at theleadingdifference@velentium.com.  PRODUCTION CREDITS Host & Editor: Lindsey Dinneen Producer: Velentium Medical   EPISODE TRANSCRIPT Episode 074 - Stuart Grant [00:00:00] Lindsey Dinneen: Hi, I'm Lindsey and I'm talking with MedTech industry leaders on how they change lives for a better world. [00:00:09] Diane Bouis: The inventions and technologies are fascinating and so are the people who work with them. [00:00:15] Frank Jaskulke: There was a period of time where I realized, fundamentally, my job was to go hang out with really smart people that are saving lives and then do work that would help them save more lives. [00:00:28] Diane Bouis: I got into the business to save lives and it is incredibly motivating to work with people who are in that same business, saving or improving lives. [00:00:38] Duane Mancini: What better industry than where I get to wake up every day and just save people's lives. [00:00:42] Lindsey Dinneen: These are extraordinary people doing extraordinary work, and this is The Leading Difference. Hello, and welcome back to another episode of the Leading Difference podcast. I'm your host Lindsey, and today I'm delighted to welcome Dr. Stuart Grant. Dr. Grant is a chartered engineer and the founder of Archetype Medtech, a consultancy and innovation studio helping medical device startups and scale ups transform early clinical, unmet needs into market ready products. With nearly 25 years of experience, Stuart has led global teams across the UK, US, China, and emerging markets delivering breakthrough innovations in hip, knee, shoulder, and trauma surgery. A highlight of his career was establishing the ASPAC Innovation Center in China, where he built R&D capability from the ground up and launched a pioneering total knee instrument system that dramatically reduced time to market. Passionate about advancing medical technology and mentoring future engineers, he bridges creativity, engineering, and regulation to accelerate safer, smarter medtech innovation worldwide. All right. Welcome to the show. It's so great to have you here today. Thanks for joining me. [00:01:57] Stuart Grant: It's lovely to be here, Lindsey. [00:01:58] Lindsey Dinneen: Yeah. Excellent. Well, I was wondering if you could start by sharing a little bit about yourself, your background, and what led you to medtech. [00:02:08] Stuart Grant: Yeah. So, I was actually, I'm obviously, as you can tell from my accent, I'm British, but I was born in Germany because my, my dad was in the military in the 1970s when I was born. So I was born actually in Berlin, which is quite interesting to be a place to be, grew up in. So I traveled around a lot here in the UK, in Germany with my dad getting posted everywhere. My mom's a nurse. So I was in medtech, not really knowing I was in medtech as a kid, but I, my family was, so yeah. And then obviously went to school, all the places I was at university. I went to university to do product design, and my goal was to be a product designer, a cool product designer, designing fancy products like Johnny Ive. And when I was looking for a job as a co-op, or an intern as you call them in the US, I was just really unsuccessful finding a job. I was doing a lot of interviews, getting turned down, sending my CV out a lot, and j happened just to advertise on the Board of University, and it said Johnson Orthopedics and no one really knew what that was in. And none of my fellow students at applied because they thought it would be designing baby bottles for putting talcum powder in and shampoo in and stuff like that. So they're like, "I'm not doing that job." So I desperately applied for it and luckily found out about all this medtech, and I've been here doing medtech for 25 years. So they gave me a job. I had to work hard to keep the job and get reemployed over and over again. But yeah, joining originally Johnson Orthopedics a long time ago is how I found out about medtech. I never knew when I was 18 that really it was a thing that existed. [00:03:47] Lindsey Dinneen: Yeah. So, okay. So you thought product design, and then when you got into medtech, what were some of the things that attracted you and that actually compelled you to stay and make a career out of it? [00:04:00] Stuart Grant: Ha. So I was a young guy with the student debts. What compelled me, I was getting paid to stay, but not to be too flippant about it, but, you know, when I was doing this engineering and design work in my early days in the CAD system, it was just so interesting. I was designing these products that were going into people or the instrumentation to make help the surgeon and going to these ORs and watching the surgeon do their job and trying to figure out how how I can make it better from their input was really interesting. I could apply it straight away, basically. In the early two thousands, there wasn't all these regulations and standards that slowed you down. So you could go and design an instrument, get it machined in the machine shop, get it clean, take it to the surgeon, he can use it, you know, probably be frowned upon 25 years later. But that's what we used to do and really adapt. And probably more interesting than going into product design and fast moving consumer goods where you're designing a, a kettle or a toaster or something, a plastic casing. It was actually much more interesting to do that. And I stayed because I spent four years here in Leeds, in the UK, was getting a bit bored and wanted to find something else to do, and then an opportunity came up in the US. So I moved over to Warsaw, Indiana, the orthopedics capital of the world, as you might know it. Worked there for, stayed there for seven years. Really enjoyed it.. People sort of bemoan Warsaw for being in the sticks in just a bunch of cornfields around it. But I enjoyed it. It's got, we had a good bunch of young friends there. I was in late twenties, early thirties at the time. There was Noah and Spikes. You'd go for a drink and some nice food. It was all right. I enjoyed my time and after that I was, after seven years, I was like, "Okay, what do I do next?" And I was looking around for jobs in medtech. Then another opportunity came up in and we were looking for people to go over and help set it up, train the staff on what MedTech product development was. And so I jumped to the chance and spent five years living in China, in Shanghai. After five years is your limit, so I had to come home. I couldn't stay. I wanted to stay, but they wouldn't allow me to. So, so I came back to the UK. And then started MDR for five years as leading the Joints MDR program, which was lots of fun, as you could probably tell, wasn't really R&D, was a lot of leadership and project management and dealing with a lot of people and a lot of problems on a day-to-day basis. And so, yeah, after that I I left J&J about three years ago and started my own product development agency. And we can talk about a little bit about that later. So that's where I am and where I got to. [00:06:50] Lindsey Dinneen: Excellent. Yeah, I definitely wanna talk about that as well. But going back a little bit-- and perhaps this is actually something that's occurred since you started your own company as well-- but are there any moments that really stand out to you along your journey of affirming that, "Hey, yeah, I actually am in the right place, in the right industry?" [00:07:12] Stuart Grant: That's a really hard one is sort of the, is the grass always greener somewhere else, type of question. Right? I guess compare, you shouldn't compare, but comparing to my friends at my university, my product design and what they've done and what I've done they've moved into the car industry a lot. Went to the car development and car industries always had its ups and downs and its problems. And you know, they've had some really cracking jobs working for McLaren and Ferrari and you know, but I think just the interesting things that medtech do that nobody really knows about is really what keeps me moving along and having conversations with people when they, you tell them like, "I used to design hips and knees and shoulders and things like that," and they're like, "Oh, my mother's got a hip and knee" and blah, blah, and you really talk about it. Actually, my mother does have a hip now and she's going in a couple months time to get the other hip done. I do know what brand she's got, so. [00:08:10] Lindsey Dinneen: See, that's really cool. Yeah. Okay. So, so, on your LinkedIn I noticed that you describe yourself as a fixer, a challenger, and a change maker, which I love. But I'd love to hear from you exactly what you mean by all those things as you have developed in your career, and now as you're doing, of course, your own consulting. [00:08:34] Stuart Grant: Yeah, so in Johnson and my colleagues are probably, I agree with this, I had a bit of a reputation of getting the more difficult projects. The, that's probably why I got MDR in the end 'cause I would always get the projects that had problems and I enjoyed that. I liked digging deep and solving the problem and wrangling everyone together and pushing everybody along to help. And that was actually one of the reasons why I moved to the US 'cause the original project I moved to was the project leader left and it was in a bit of a shambles. So I went over to sort of, sort of try and get it together and just ended up staying and working on multiple projects. So I like that. Really challenging, not just the engineering side. The engineering side is obviously really interesting, but the challenging project management and people management and process management in a big corporation, all of those things, people, product, process, all come together just to cause a big headache sometimes, you know, herding cats as say and going, trying to solve those problems as an engineer, always trying to solve these problems, right? So it's you're always trying to figure out how you can move forward. [00:09:52] Lindsey Dinneen: Yeah. Yeah, absolutely. So, okay, so that kind of brings us to the company. So what was it like going from employee to entrepreneur? Were you, did you feel ready and prepared for that leap? Or what has that transition and pathway been for you? [00:10:10] Stuart Grant: So I've, I was a long-term planner. I was planning for this for five years whilst I was working for Johnson. So I went and got, when I came back to the UK I started my PhD and I knew getting a PhD was a real way of building credibility immediately, right? Before you step in a room and have a conversation with you, if you've got a PhD in the subject you're about to talk about, people pay attention, hopefully. Right? So I did my, so I did my PhD in Medtech Product Innovation, what the process is. So I spent seven years part-time working for Johnson, getting my PhD, knowing that eventually in my mid forties, there'll be an inflection point, which usually isn't people in big corporations, right, that either stay to the end for until you're six, mid sixties. If you hit 50, usually stay for the next decade, right? Or you leave and do something else. And I was like, "Okay, 45, I'm gonna pull the bandaid, go in, get my PhD, set up my own company plan, get the plan to do it, get the savings," and so I was working on MDR and a new MDR was coming to an end, and then they'd have to find me a new project, which probably didn't exist. So I also knew that J&J would be like, "Ah, Stuart, you've been here for 23 years. There's not really anything of your level here." I'd be like, "Great, let's go." So this was all a, you always it's a big step, right? I have a family. I can't just sort of walk in, not come in the office anymore. So it was a big plan that my wife and I had for quite a number of years to execute. So it's still a struggle. I've been doing it for three years. It's still hard work, still building the company, finding clients, understanding what their pain points are and improving your picture and all those other things, still is still a challenge, but it's a new challenge. [00:12:06] Lindsey Dinneen: Yeah. [00:12:07] Stuart Grant: And as I say, as I said, when people worry about the risk, it's like I can easily just go and get a corporate job again as a move back and have all this new relevant experience. So it's a risk, but you have to balance that by the benefits. [00:12:21] Lindsey Dinneen: Yeah, calculated risk that you've planned for, so good for you. So, okay, so tell us a little bit about your company now and who you help and kind of where in the development or even ideation process that you can come in and really make a difference. [00:12:40] Stuart Grant: So, yeah, so Archetype MedTech is a product development, product innovation agency. And what we do, we usually work with startups or scale ups. Startup side, they'll have a proof of concept. They've already defined the unmet clinical need. They've sort of wrangled the technology and validated the actual technology does what it they're trying to make it do, but they just dunno how to make this a medical device product, right? They've they've got the technology, but they dunno how the product make a product that's sellable is releasable and it gets approved by FDA or here in the, i'll say here in the EU, I know I said in the UK, but MDR and I help them work out that product innovation strategy. So take them all through either they need to do the frontend innovation and understand their needs and the insights and the business case, and then the engineering requirements and specifications. The design and engineering part I help them with, and this is not just me. I have a network of experts, a sort of consortium of experts that come together and bring all these different specialties and then we help them with the testing, what testing they need to do, their risk management, usability, all that fun stuff. And then contact and help them work with the manufacturers. So contract manufacturers, then their regulatory approval. So really what we try to do is, 'cause we're bringing all this expertise as a group of people together, the entrepreneur, usually a salesman or surgeon at this point, who may be a university spin out, can spend a lot of time and money trying to find these experts, trying to find these resources, trying to understand the product development, the MedTech product development process, which is all written down in various books, but when you get down to the details, it gets really complicated. So what we do is help them go through that as fast and as efficiently as a possible, so they're not wasting capital fishing around for those experts. We already have that network of experts that we can bring in and take them through the process as quickly as possible. So that's what Archetype Medtech do for our clients. And has been successful. We have quite a number of clients, mostly in orthopedics and surgical 'cause that's my specialty in medtech. And what we also do, we just don't want to be a management consultancy firm. Well, we do if it's right, we share what we call expertise for equity. So we'll take some equity from the company, but we'll cut our day rates or maybe do it for free, do and help them go through the process as quickly as possible. That means we've got skin in the game, right? We're not just taking their money and going, "Great. This is great. Good luck on the commercialization. Not our problem." [00:15:29] Lindsey Dinneen: Right. [00:15:30] Stuart Grant: It is our problem. 'cause we want a return on our risk and our investment as well. So, yeah, that's what we try to do. And along with that we do a load of pro bono work with surgeons in the NHS who have had ideas. We help them just get their idea a bit further along so they can start looking for funding and investment, and I can share that with you later 'cause it's a really important program that the NHS run it. If there's any mentors out there that want to get involved I can point them in the right direction. [00:16:00] Lindsey Dinneen: Actually that's fantastic and I would love to hear a little bit more about the organization and yeah, how people can get involved and help and what do they all do. [00:16:10] Stuart Grant: Yeah. So the NHS have set up this called NHS Clinical Entrepreneurs Program. This is not my company. This is a completely separate organization. And what it is, clinicians, anybody who works in the NHS-- you know NHS is a 1.6 million people who are employed in the NHS. It's a massive company organization. They come up with clinical needs 'cause they're in the problem and they start working out how they solve it, even through medical device or health tech or an app or anything, right? And they can go into this, it is basically the equivalent of an accelerator program over about nine months. And we have mentors like myself who work with those clinicians to help them develop their idea. So I've got a couple of clinicians that I work with. One is developing a neurosurgical device for helping him cut out tumors in the brain. At the moment, they use two tools. They use a scalpel and a cordy, a bipolar cordy, and they're very basic tools. And what he has to do, he's under a microscope, and he has to swap these one by one, does this scalpel to cut the vascularization of the tumor. Then he has to seal it. And he has to pass the nurse has to pass in these tools and he can't see a, see the nurse passing him. So he is like, "Can I develop a tool that's in one a scalpel and a bipolar" so he doesn't have to keep changing the tool in his hand? And you can know by the cognitive load and changing that tool in the field that these surgeries take eight to 12 hours to cut out a tumor from the brain. So he's saying every, he swaps his tool about 200 times and it takes three seconds. So you can start doing the maths. [00:17:59] Lindsey Dinneen: Yeah. [00:18:01] Stuart Grant: Yeah. And then the other, so the other is a doctor, actually, the doc is a neonatal doctor and he's trying to develop a langoscope for neonatal babies. The langoscopes at the moment haven't really improved in the last 60 years. The Muller blades, they're called, and they're the stainless steel things that basically adult ones have been shrunk down to baby size and changed a little bit. They're not very good. And when you've got a newborn baby who's struggling to breathe, the mother's there obviously upset, so the father's probably there and you're trying to get langoscope down their throat, it's not a great, it is a very stressful situation, so he's kind of developed a, trying to develop a better one, right? Even the simple things. These things are made of stainless steel and you put a piece of metal on a baby's tongue. A newborn baby's obviously never experienced cold before, so they obviously start freaking out and squirming and you're trying to get this thing down her throat. It's crazy. So I'm helping him to see if he can come up with a better solution. He's got a, got an idea at the moment. He's developed some prototypes and we're gonna help him get it, see if we can get it a bit further along, and hopefully get to the market and solve this real small unmet clinical need, but really important one. [00:19:16] Lindsey Dinneen: Yeah. That's incredible to hear about both of those stories. That is really exciting. I love I-- this is partly why I love this industry so much is the innovation coming out of it is always amazing. People care so deeply about making a difference and improving patient outcomes, and then to hear about those kinds of innovations, ugh, that's awesome. [00:19:38] Stuart Grant: Yeah. Yeah. So if there's any experts out there listening who wanna get involved in the N-H-S-C-E-P program, I know Australia does one too. So yeah, get involved and share your knowledge freely to some clinicians who wanna, who have found an unmet clinical need and wanna solve it, but don't know how to. [00:19:56] Lindsey Dinneen: Yeah. Love it. That's fantastic. So it, it seems like, you know, from your career trajectory and your continuing education all this time that you are not someone who sits still very well. And I think you mentioned this a little bit in your LinkedIn profile, you like to keep moving. So one of the things that I noticed that you do, and I'd love if you share about it, is you do lectures on the history of innovation. Could you share a little bit about that? [00:20:24] Stuart Grant: Yeah. So. I I really, so I sort of got into reading about innovate. I love reading innovation books, right, nonfiction, innovation books, which I got in about 10 years ago. I read probably one of the first one was "The Idea Factory," which is about Bell Labs. And that was how Bell Labs has invented the telephone system and invented the transistor, won a load of Nobel Prizes. Shockley and Bardine were there. They just had this crazy Medici effect going on in Bell Labs. The Medici effect when you collect everybody together in a small area and they just start bouncing ideas and coming up with some hugely creative solutions. And that comes from Florence when DaVinci and Michelangelo and Raphael were all kicking about Florence and they were all paid for by the Medici family, so this why it's called the Medici. There's a book about it actually called "The Medici Effect." So I started reading all this and started just going backwards in history and getting to the industrial revolution and how the industrial revolution happened. And going further back to these group of men called the Lunar Men who were in Birmingham here in the UK who basically, it was James Watt, who invented the steam engine, Wedgewood, who was the pottery guy. It is Rasmus Darwin, who was Charles Darwin's great-grandfather. Yeah. All these people, they were called the Lunar Man 'cause they met every month in the full moon and discussed ideas and I think probably got drunk. [00:22:00] Lindsey Dinneen: I mean... [00:22:03] Stuart Grant: So yeah, I just love reading it and you know, I love, I'm now a little bit of a brag. As of last month, I'm a fellow of the Institute of Mechanical Engineers, and that is quite prestigious that was created by George Stevenson, and George Stevenson was the guy who created the steam train. [00:22:23] Lindsey Dinneen: Okay. [00:22:23] Stuart Grant: So we took Watts' idea of the steam engine, put it on wheels, figured out how to work. And I love, I just love steam trains and that's very dorky of me, I know. But I love, as a mechanical engineer, just seeing all the bits move and actually seeing them chug around all the noise and the steam. And here where I live in Yorkshire, in the UK, up the road in York is the National Railway Museum, which all the steam trains are at. Darlington is west. George Stevenson had his the original railway, the Darton Stock Railway. So George Stevenson created the Institute of Mechanical Engineers 'cause he was a mechanical engineer and his son created the rocket the first really fast once, Robert Stevenson. So learning all this and then figuring out how, then I went back-- I'm, so this is a long answer to your question-- then I went back went back and like understood why the industrial revolution happened and it was all about the banking system here, how people could get capital. And then the legal system grew up to protect that capital. And then agriculture improved in the UK so people weren't just stuck on farms, subsistence farming. There was enough food being produced to support the population so the population could go and work in factories and obviously James Watt creating the steam power created more power. So people in horses and everybody didn't have to work so hard. And then there was politics involved with the Hugonos, which were the Protestant, the French Protestants came over and they had all, they had the ability to make all these machine parts, 'cause that's our skill. Some of them came to the UK and the others went to Switzerland. And that's where the watch industry in Switzerland created. And then, you know, and then the scientific approach and the enlightenment came in the UK and it all just sort of bubbled up into the industrial revolution and then cascaded through the 19th century and the 20th century in. Here we are in the 21st century. So I just love knowing that whole pathway of somebody said "We need more legal," and then somebody said, "We need more banking" and as startups, right, investment is the king. So it all started 300 years ago with the UK banking system. [00:24:35] Lindsey Dinneen: Fascinating. Oh my goodness. That is so interesting. Yeah. Okay. One other interesting thing I caught from your LinkedIn profile is that you are a painter, but you are an exhibited painter, yes? [00:24:51] Stuart Grant: Yeah, I, well, I try. [00:24:54] Lindsey Dinneen: Okay. [00:24:54] Stuart Grant: So yeah. Obviously I did product design right? And I did product design because at school, I was good at art and I was good at maths and physics. So I was looking around going, "What discipline do those three things fit together?" And it looked like it was product design. I was like, "Okay, I'm half an engineer, half an artist, not good at either." So about 10 years ago I decided to pick up art again. It was, started to go to classes and doing landscapes and actually sadly the industrial decline of Britain's, so the old buildings of the industrial revolution and stuff like that. So I paint that stuff. [00:25:36] Lindsey Dinneen: Oh, that's so cool. [00:25:37] Stuart Grant: Put it into exhibitions and sometimes get rejected, sometimes get accepted, and try and sell a couple so I can at least call myself an artist. [00:25:45] Lindsey Dinneen: There you go. I love it. Yeah. Well, and that creativity and that artistry does, you know, impact your work in general, because I think sometimes having that outlet actually spurs some just creative solutions outside of the box that, you know, might have not come to you immediately if you were just like, you know, head down, really working hard on this project. And then if you could take a step back do you feel that it helps you in that way at all? [00:26:15] Stuart Grant: Yeah. Yeah, it definitely does. Not thinking about work is and just having it percolate in the background and not actually, 'cause it's a very slow deliberate process painting, right? So it does, you just lose hours and hours painting something, which is really nice. Obviously I've got a, I've got a 5-year-old at the moment running around, so I don't do that much painting. I usually just reserve it for when I go to my art class on Wednesday nights 'cause trying to focus is not a thing for a 5-year-old. [00:26:46] Lindsey Dinneen: Yeah, That's fair. Okay. Well, all right, so pivoting the conversation just for fun. Imagine that you were to be offered a million dollars to teach a master class on anything you want. It could be within your industry. It also could be your history of innovation, but what would you choose to teach? [00:27:08] Stuart Grant: So I thought about this when you gave that question because I was like, "Well, I've already talked about the history of innovation and that can pretty boring." So my other boring side, when you do a PhD, you always wish you did another subject. That's the thing is like, I wish I studied that instead. So my, as you go through the PhD, you learn other things and you're like, "Oh, that's really interesting." And you go down rabbit holes and you're like, "Oh, well stop. That's not my job. That's not what I'm trying to do here." One of the ones was how technology and society are interlinked. So technology drives society, and we've got lots of examples of that. Steam engines, trains, telephones, electricity, light bulb, broadband, and now AI. And so technology affects society. Then society drives technology. They're a virtuous circle. Some people say it not virtuous at all, but they, that's what happens. And understanding how those two things, society and culture and technology all interact is really interesting to me. And obviously not all technologies are adopted. Some are abandoned. Sometimes the better technology is abandoned for an inferior technology for lots and lots of reasons. There's examples. In the eighties, it was VHS and beta max, Blu-ray and HD DVDs. And what else? The keyboard, QWERTY keyboard is meant to be terrible. And that was designed 'cause of typewriters at the time. So the keys didn't smash together, but obviously that's not needed anymore. So those things interest me and I like to study that more, but I like to study it. Thinking about medtech and how our technology in medtech has affected society and using that lens 'cause we also always talk about clinical needs, right? What's your unmet clinical need? What are you trying to solve here? But there's also a social and cultural need that you are maybe not addressing directly, but you are addressing it. And how that drives medtech, and you know, it's we talk about like medtech equality and democratizing medtech and making it more accessible, but there's always the flip size of medtech inequalities. The big one probably at the moment is robotic surgery. Hugely expensive. Only available to very few. So how will that filter through society? How does that affect society? Will it just be for the rich developed countries to use robotic surgery? How will that affect it going forward the next 10, 20 years? Because it uses a capital equipment, right? They can't be diffused through society very easily. So that, that's one thing I would like to study and sort of talk about a little bit more, 'cause I think it's really interesting, especially now AI is being talked about and how digitizing healthcare is gonna happen over the next decade. Interesting if we're overclaiming that at the moment and a lot of startups are overclaiming, what they can really do and is it gonna, is there gonna be a backlash? Who knows? Let's see. In our, maybe in a decade, I'll present a course on it. [00:30:23] Lindsey Dinneen: There you go. Okay. And time will tell. Alright. I like it. Very cool. Okay. And how do you wish to be remembered after you leave this world? [00:30:34] Stuart Grant: Yeah. My PhD was like, I would probably like, I'd like to remember my PhD findings, but I'm like, no, who cares? [00:30:44] Lindsey Dinneen: Oh. [00:30:45] Stuart Grant: I, I've got, of course, my family, making an impact on my, what I've done here with my family, but, and I was really thinking about this question earlier. I was like, "Well, I hope this isn't the end. I hope I haven't peaked." [00:31:02] Lindsey Dinneen: Yes, that's fair, okay. [00:31:06] Stuart Grant: So maybe the next 20, 30 years, hopefully I'll be remembered for something, I hope. [00:31:12] Lindsey Dinneen: Okay. To be determined. I like that. I like that a lot all right. [00:31:18] Stuart Grant: It's a positive. [00:31:20] Lindsey Dinneen: Yeah. It's, and it's a forward way of thinking that, you know, you don't have to limit yourself to what you've already done or accomplished or seen. Who knows? The world is exciting. Yeah. I like it. Okay. [00:31:33] Stuart Grant: Well, yes, I'm yeah, definitely. [00:31:35] Lindsey Dinneen: Yeah, all. [00:31:36] Stuart Grant: One of the things we're doing-- I was looking at the Australian MedTech market and really just trying to figure out what's going on to see if there's anything I can do there. And talking to my wife, we decided, 'cause my daughter's not at school yet, we decided, "Let's go to Australia for an extended holiday." And it was gonna be like a month and we'll start working it all out, like we're just gonna go for three months, March, April and May this year, to sort of experience Australia, experience the MedTech market, go meet a lot of people, understand and just sort of grow and try to understand another way of people. I know Australia, they've got a similar culture to the UK and the US. But they do, they are far away. So they have a different take on things. And I wanna see what a difference is and see if I can get involved. So we're off to Australia on the MedTech market, so if anybody's listening, reach out to me on LinkedIn. It'll be we'll hopefully when I'm over there, we are in Brisbane. We can meet up. [00:32:32] Lindsey Dinneen: Excellent. Yeah, no, that's really exciting. And I actually have a few people I can connect you with as well, so, yeah. Okay. And then final question. What is one thing that makes you smile every time you see or think about it? [00:32:48] Stuart Grant: Oh. I think it's, it is back to my old answers, it's back to the steam trains. I just love watching the mechanism going around. My, me and my daughter who's exhibiting engineering characteristics, shall we say. Love, we love going to the railway museum and running around 'cause you can go and touch the trains, you can get on them, you can get your hands greasy if you want to, if you touch the wrong bit of it. She loves seeing them. And they're just, so when these engineers designed all these big bits of metal, they didn't have FEA or CAD or anything. They just sort of took a guess at the curves and how it should look. And some of these parts they designed are so beautiful when you start looking at them, it just makes me smile, like there was a person, a man, we'll have to say a man, right, 'cause it was 200 years ago... [00:33:44] Lindsey Dinneen: Right. [00:33:44] Stuart Grant: A engineer who decided he was gonna make it like that out of wood. And they were cast into iron and they just they were just sitting in their shop and just did what they thought was right. And most of the time it didn't break. [00:34:00] Lindsey Dinneen: Most of the time. There you go. Yeah. That's great. I love that. Well this has really been a fantastic conversation. I'm so grateful for you joining me today and sharing just some of your history and you know, what you're looking forward to next. I think it's, I think it's really incredible when you get to combine all the different things, like you said. You've got sort of that design and problem solving and you've got the engineering and you've got all these cool things that just make you an incredible help to the MedTech industry. And we're excited to be making a donation on your behalf, as a thank you for your time today, to Sleep in Heavenly Peace, which provides beds for children who don't have any in the United States. So thank you for choosing that charity to support. Thanks for joining and thanks for everything you're doing to change lives for a better world. [00:34:52] Stuart Grant: Yeah, thanks, Lindsey. It's been a real pleasure talking to you. [00:34:55] Lindsey Dinneen: Yeah, absolutely. Thank you again. [00:35:00] Dan Purvis: The Leading Difference is brought to you by Velentium Medical. Velentium Medical is a full service CDMO, serving medtech clients worldwide to securely design, manufacture, and test class two and class three medical devices. Velentium Medical's four units include research and development-- pairing electronic and mechanical design, embedded firmware, mobile app development, and cloud systems with the human factor studies and systems engineering necessary to streamline medical device regulatory approval; contract manufacturing-- building medical products at the prototype, clinical, and commercial levels in the US, as well as in low cost regions in 1345 certified and FDA registered Class VII clean rooms; cybersecurity-- generating the 12 cybersecurity design artifacts required for FDA submission; and automated test systems, assuring that every device produced is exactly the same as the device that was approved. Visit VelentiumMedical.com to explore how we can work together to change lives for a better world.

OpenAI is nearing a $100B+ fundraise, Meta's Mark Zuckerberg testified at a landmark social media addiction trial in California, and Andrew Mountbatten-Windsor has been arrested on suspicion of misconduct tied to Jeffrey Epstein. Legendary media investor Mario Gabelli discusses the Netflix-Paramount battle for Warner Brothers Discovery's film and media assets. Plus, as an MSG shareholder, Gabelli weighs in on MSG's exploration of splitting the Knicks and the Rangers. Two-time Nobel Prize-winning economist Joseph Stiglitz shares his perspective on President Trump's economic agenda, including the impact of tariffs on inflation and consumer sentiment. Happy Birthday, Andrew! Mario Gabelli - 12:40 Joseph Stiglitz - 27:01 In this episode: Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Born Chloe Ardelia Wofford in Lorain, Ohio, Toni Morrison rose from a working-class Midwestern childhood to become one of the most influential literary voices of the 20th century. From her early days studying at Howard and Cornell to her trailblazing career as an editor at Random House—where she championed African American writers—Toni's path was as powerful as the stories she told. We dive into the emotional depth and historical weight of novels like Beloved, The Bluest Eye, and Song of Solomon, examining how Toni centered Afrian American interior lives with lyricism, honesty, and unflinching truth. In 1993, she became the first African American woman to receive the Nobel Prize in Literature, cementing her place in global literary history. Follow us on IG: @homance_chronicles Connect with us: linktr.ee/homance Send us a Hoe of History request: homancepodcast@gmail.com

What if the thing shaping almost every decision you make is happening quietly — without you realizing it? John breaks down a powerful idea from psychologist and Nobel Prize winner Daniel Kahneman: there are two selves at play — the experiencing self (who lives life moment-to-moment) and the remembering self (who tells the story and makes most decisions). When those two don't agree, you can end up living a life that looks “right” on paper… but still feels empty inside. MENTIONED / LINKS (Daniel Kahneman – Nobel Prize) Nobel Prize profile (2002, Economic Sciences): https://www.nobelprize.org/prizes/economic-sciences/2002/kahneman/facts/ Daniel Kahneman (Wikipedia): https://en.wikipedia.org/wiki/Daniel_Kahneman Thinking, Fast and Slow (book): https://en.wikipedia.org/wiki/Thinking,_Fast_and_Slow PRACTICAL TAKEAWAYS (2-QUESTION FILTER) Before a major decision (work, love, moves, commitments), ask: “How does this feel in my body right now?” “When you look back on this in 5 years, will I be glad I did it?”

If AI continues to develop without appropriate guardrails, a worst-case scenario could lead to human extinction, warns the 'godfather of artificial intelligence ' Geoffrey Hinton. But the Nobel Prize winner has a solution: AI must foster 'maternal' instincts, empathy and kindness. Hinton tells host Nahlah Ayed that it's fairly inevitable AI will become smarter than humans, but if we could make it care more for us than it did about itself, good things could happen.

Intermittent fasting is the most Googled diet-related term on the planet, except everyone who does it will tell you it's not a diet. It's a protocol. An eating window. A lifestyle. An optimization hack. Definitely, absolutely, under no circumstances a diet. You just don't eat for sixteen hours. Totally different.In this episode, we trace IF from ancient religious fasting traditions through its secularization and commodification, afrom Martin Berkhan's Leangains forum and its tagline ("fuck breakfast") to Michael Mosley's BBC documentary, Hugh Jackman's Wolverine physique, and Jack Dorsey describing his weekend-long fasts as "hallucinating" like that's a selling point. We walk through how a Nobel Prize in yeast biology became a justification for skipping breakfast, why Jason Fung's The Obesity Code scored 31% on scientific accuracy and still became the IF bible, and how the fasting app market turned one simple rule into a multimillion-dollar industry.Then we get into what the science actually says. We break down the claimed mechanisms — metabolic switching, autophagy, insulin sensitivity — and look honestly at where the evidence lands. Spoiler: the mechanisms are real, but the confidence far outpaces the human data. The first direct measurement of autophagy in humans was published in 2025. Mouse metabolism runs seven times faster than ours. And the landmark Liu et al. trial in the New England Journal of Medicine found that time-restricted eating is no better than regular caloric restriction for weight loss. You're not metabolic switching. You're just eating less.We also dig into what IF means for active people (no performance benefit across any exercise type, real risk of under-fueling and RED-S, and a protein distribution problem that no eight-hour window can solve), what the AHA, ADA, NIA, and ISSN actually say about it, and the robust research linking IF to eating disorder behaviors across all genders — including a landmark study showing that fasting was a stronger predictor of binge eating disorder than any other form of dietary restraint. Fasting is listed in the DSM-5 as a compensatory behavior. Just because you give it a different vocabulary doesn't mean your body experiences it differently.Your body is smarter than any fasting app. Also, breakfast slaps..This Episode's Sponsors:rabbit — Code YDSFEB for 10% offOsmia — Code YDS20 for 20% offTailwind — Code YOURDIET20 for 20% offMicrocosm Coaching — Book a free consultationFull references, episode archive, and our advertising ethics policy at yourdietsuckspodcast.comHosted by: Zoë Rom & Kylee Van Horn, RDN

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What if the reason your business feels heavy isn't a strategy problem — it's an identity problem?And what if the very thing that made you successful is the exact thing keeping you stuck?In this episode, I'm sitting down with Eleanor Beaton — host of the Woman-Owned podcast, founder of Saffy Media, and one of the sharpest minds I know when it comes to helping women scale sustainably. Eleanor has spent years studying and coaching women entrepreneurs through the identity shifts required to go from doing all the things to leading the things — and she's wildly transparent about what that journey actually looks like (jealousy, embarrassment, and all).We dig into her framework of moving from producer to replicator to multiplier, the three levels of trust you need to build before your business can truly grow, why "subtract to multiply" is the most counterintuitive and important scaling advice you'll hear, and what Dr. Claudia Goldin's Nobel Prize-winning research says about women, work, and the long game. This one is a masterclass.What You'll LearnThe producer → replicator → multiplier framework and why most women leaders get stuck at stage oneThe surprisingly uncomfortable emotions that surface when your team starts getting the credit (and why you have to feel them to grow past them)Why "the amateur is always in a rush and the master never hurries" — and what healthy pacing actually looks like at different stages of growthThe "subtract to multiply" principle: simplicity scales, complexity fails — and how to audit your business for itResources Mentioned in This EpisodeEleanor's Podcast — Woman-Owned: https://podcasts.apple.com/us/podcast/woman-owned-the-growth-podcast-for-women-entrepreneurs/id1102833537Eleanor's Scaling Tools at Saffy Media: https://saffymedia.co

Open up some scientific papers, and you'll hear electroconvulsive therapy described as the most effective treatment for depression (especially very severe depression). But open up others, and you'll see it described as completely useless—and a sad indictment on a medical establishment who've completely failed to provide proper evidence on it. Not only that, but they've exposed patients to serious side effects, like memory loss, for no good reason.Who's right? In this episode, we look into the most controversial psychiatric treatment since lobotomy.NEXT WEEK: we'll follow this with an episode on another controversial psychiatric treament: antidepressants.On this week's episode we discussed the article “The Perks of Being a Mole Rat”, from our sponsor, Works in Progress magazine. As ever, we're very grateful for their support. You can find many more excellent articles at worksinprogress.co.Show notes* 1937 article by Egas Moniz, lobotomy Nobel Prize-winner* Weird 1998 article defending him on the Nobel Prize website* Megan McArdle on Walter Freeman* The ECT scene in One Flew Over the Cuckoo's Nest* 2024 article discussing the possible mechanisms of ECT's effect* 2010 review about sham ECT studies* 2019 review of each individual sham ECT study and the meta-analyses that include them* 2022 response to the review* Response to the response* Contemporary news article about the controversy* 2021 article in defense of ECT* The parachute RCT* 2010 meta-analysis on cognitive effects* 2025 meta-analysis on autobiographical memory lossCreditsThe Science Fictions podcast is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sciencefictionspod.substack.com/subscribe

Simon and Rachel speak to Jacques Testard, the founder and publisher of Fitzcarraldo Editions, an independent house based in London that, since its establishment in 2014, has won four Nobel Prizes for literature. Jacques's Nobel winners are Svetlana Alexievich (2015), Olga Tokarczuk (2018), Annie Ernaux (2022) and Jon Fosse (2023). Prior to setting up Fitzcarraldo, Jacques co-founded The White Review, a literary magazine launched in 2011. He's also published work by Claire-Louise Bennett, Jon Lee Anderson and Fernanda Melchor. We spoke to Jacques about setting up Fitzcarraldo and releasing its first book in 2014, its extraordinary success with literary prizes, including the Nobel, and the economics of running a small publishing house.In addition to the standard audio format, the podcast is now available in video. You can check us out on YouTube under Always Take Notes.  Join us on April 21st as we interview Michael Morpurgo at the Lantern Theatre in Bristol. You can get your tickets here.  We've made another update for those ⁠⁠⁠⁠⁠⁠⁠⁠who support the podcast on the crowdfunding site Patreon⁠⁠⁠⁠⁠⁠⁠⁠. We've added 40 pages of new material to the package of successful article pitches that goes to anyone who supports the show with $5 per month or more, including new pitches to the New York Times, the Washington Post and the BBC. The whole compendium now runs to a whopping 160 pages. For Patreons who contribute $10/month we're now also releasing bonus mini-episodes. Thanks to our sponsor, Scrivener, the first ten new signs-ups at $10/month will receive a lifelong license to Scrivener worth £55/$59.99 (seven are left). This specialist word-processing software helps you organise long writing projects such as novels, academic papers and even scripts. Other Patreon rewards include signed copies of the podcast book and the opportunity to take part in a monthly call with Simon and Rachel. A new edition of “Always Take Notes: Advice From Some Of The World's Greatest Writers” - a book drawing on our podcast interviews - is available now. The updated version now includes insights from over 100 past guests on the podcast, with new contributions from Harlan Coben, Victoria Hislop, Lee Child, Megan Nolan, Jhumpa Lahiri, Philippa Gregory, Jo Nesbø, Paul Theroux, Hisham Matar and Bettany Hughes. You can order it via ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Waterstones⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Kriege, Krisen, Klimakatastrophen, soziale Spaltung – ein Blick aufs Handy reicht, und viele fühlen sich von den Nachrichten überfordert. Das Leid der Welt scheint plötzlich auf den eigenen Schultern zu liegen. Dieses Gefühl hat einen Namen: Weltschmerz. In dieser Folge von Betreutes Fühlen sprechen Leon und Atze darüber, warum uns das aktuelle Weltgeschehen emotional so stark belastet, was Dauerkrisen mit unserer psychischen Gesundheit machen und warum Abstumpfen keine Lösung ist. Es geht um Empathie, emotionale Überforderung und den Unterschied zwischen Mitfühlen und Wegschauen – aber auch darum, warum Empathie allein nicht reicht. Wozu ist dieser Schmerz da? Und wie können wir mit Weltschmerz umgehen, ohne uns ohnmächtig oder leer zu fühlen? Fühlt euch gut betreut Leon & Atze Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Vorverkauf 2026: https://betreutes-fuehlen.ticket.io/ Quellen: U.S. Department of Justice (SDNY) United States v. Jeffrey Epstein – Indictment & Press Release. → Grundlage für die Einordnung sexualisierter Gewalt, Machtmissbrauch und struktureller Wegschau-Dynamiken zu Beginn der Folge. https://www.justice.gov/usao-sdny/press-release/file/1180481/dl The Examined Life – Stephen Grosz → Warum Schmerz eine wichtige psychische Funktion hat und was passiert, wenn wir ihn nicht mehr fühlen Pei, R., Grayson, S. J., Appel, R. E. et al. (2025). Bridging the empathy perception gap fosters social connection. Nature Human Behaviour. → Zentrale Studie zur „Empathy Perception Gap“ https://doi.org/10.1038/s41562-025-02307-1 Moralische Ambition – Rutger Bregman (2024) → Die Idee, Weltschmerz nicht nur zu fühlen, sondern ihn in sinnvolles, wirksames Handeln zu übersetzen. Altruistic Personality – Samuel P. Oliner (1992) → Frühe psychologische Forschung zu Menschen, die im Nationalsozialismus Juden retteten – und warum „der gute Charakter“ allein keine Erklärung ist. Conscience and Courage – Eva Fogelman (1995) → Ergänzende Interviews mit Helfer:innen, die zeigen, wie gewöhnlich Widerstand leistende Menschen oft waren. Varese, F., & Yaish, M. (2000). The importance of being asked. Rationality and Society. → Schlüsselbefund der Folge: Der wichtigste Faktor für Helfen ist, gefragt zu werden. https://doi.org/10.1177/104346300012003003 Arts and Minds – Anton Howes (2020) → Wie Fortschritt, Innovation und Hoffnung sozial „ansteckend“ werden können – Parallele zur moralischen Ambition. Building a Life Worth Living – Marsha Linehan → Das Karten-Beispiel und das Konzept radikaler Akzeptanz: Die Realität annehmen, um sie verändern zu können. Abundance – Ezra Klein & Derek Thompson (2025) → Gegen den Fatalismus: Warum Zukunftsvisionen von Überfluss Hoffnung zurückbringen können. CNBC (2023). Nobel Prize winner Katalin Karikó on being demoted and perseverance. → Grundlage für das „Karikó-Problem“: Wie Institutionen mutige, riskante Ideen systematisch ausbremsen. https://www.cnbc.com/2023/10/06/nobel-prize-winner-katalin-karik-on-being-demoted-perseverance-.html Empfehlungen YouTube-Interview mit Katalin Karikó & Drew Weissman über wissenschaftliche Beharrlichkeit, Zweifel und den langen Weg zum Durchbruch. https://www.youtube.com/watch?v=-3x4IMdeFdI Rki: Walther L, Vogelgesang F. Schaffrath Rosario A, Kersjes C, Thom J. Peitz D, et al. Depressive und Angstsymptomatik bei Erwachsenen in Deutschland: Ergebnisse aus dem Panel Gesundheit in Deutschland" 2024. J Health Monit. 2025. Angst und Depressionssymptome: Mauz, E., Walther, L., Junker, S., Kersjes, C., Damerow, S., Eicher, S.,... & Thom, J. (2023). Time trends in mental health indicators in Germany's adult population before and during the COVID-19 pandemic. Frontiers in public health Redaktion: Julia Ditzer, Dr. Leon Windscheid

The city did not just inherit brilliance. In many cases, it saved it.

In today's episode from the Vault, we revisit Nadine Gordimer's James Lecture on the political landscape of South Africa, presented at the New York Institute for the Humanities on October 14, 1982. In 1982, resistance to South Africa's apartheid was growing increasingly militant, and the state's brutal repression heightened this tension. In her lecture, Gordimer speaks directly to this political landscape, describing the period as an “interregnum." She discusses the crisis of white identity in South Africa, the relationship between art and politics, the urgency for an alternative political left working toward what she calls a democracy without economic and military terror. This lecture was the basis of Gordimer's essay “Living in the Interregnum,” published in the New York Review of Books in January of 1983. Nadine Gordimer was a South African writer and political activist. She authored fifteen novels, including The Conversationalist, Burger's Daughter and July's People, over two hundred short stories, and several volumes of essays. She was awarded the Booker prize for the Conversationalist in 1974 and the Nobel Prize in Literature in 1991. She died in 2014 at the age of 90 in Johannesburg, South Africa. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

In today's episode from the Vault, we revisit Nadine Gordimer's James Lecture on the political landscape of South Africa, presented at the New York Institute for the Humanities on October 14, 1982. In 1982, resistance to South Africa's apartheid was growing increasingly militant, and the state's brutal repression heightened this tension. In her lecture, Gordimer speaks directly to this political landscape, describing the period as an “interregnum." She discusses the crisis of white identity in South Africa, the relationship between art and politics, the urgency for an alternative political left working toward what she calls a democracy without economic and military terror. This lecture was the basis of Gordimer's essay “Living in the Interregnum,” published in the New York Review of Books in January of 1983. Nadine Gordimer was a South African writer and political activist. She authored fifteen novels, including The Conversationalist, Burger's Daughter and July's People, over two hundred short stories, and several volumes of essays. She was awarded the Booker prize for the Conversationalist in 1974 and the Nobel Prize in Literature in 1991. She died in 2014 at the age of 90 in Johannesburg, South Africa. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

In today's episode from the Vault, we revisit Nadine Gordimer's James Lecture on the political landscape of South Africa, presented at the New York Institute for the Humanities on October 14, 1982. In 1982, resistance to South Africa's apartheid was growing increasingly militant, and the state's brutal repression heightened this tension. In her lecture, Gordimer speaks directly to this political landscape, describing the period as an “interregnum." She discusses the crisis of white identity in South Africa, the relationship between art and politics, the urgency for an alternative political left working toward what she calls a democracy without economic and military terror. This lecture was the basis of Gordimer's essay “Living in the Interregnum,” published in the New York Review of Books in January of 1983. Nadine Gordimer was a South African writer and political activist. She authored fifteen novels, including The Conversationalist, Burger's Daughter and July's People, over two hundred short stories, and several volumes of essays. She was awarded the Booker prize for the Conversationalist in 1974 and the Nobel Prize in Literature in 1991. She died in 2014 at the age of 90 in Johannesburg, South Africa. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-studies

Economic policy in the second Trump administration continues to undergo significant change. Many of these changes have been enacted through executive orders. What effect have these policies had on economic growth, scientific research, and on American institutions thus far? How might they impact U.S. leadership over the long-term? Simon Johnson joins EconoFact Chats to discuss these questions, drawing on a new book he co-edited, 'The Economic Consequences of the Second Trump Administration: A Preliminary Assessment.' Simon is the Ronald A. Kurtz Professor of Entrepreneurship at the MIT Sloan School of Management, where he heads the Global Economics and Management Group. He served as Chief Economist at the International Monetary Fund in 2007–2008 and was a co-recipient of the Nobel Prize in Economics in 2024.

Max Pearson presents a collection of the week's Witness History interviews from the BBC World Service. Our guest is Scottish writer, editor and music programmer Arusa Qureshi.We start in 1989 when the British rock band Pink Floyd played a highly controversial concert in Venice. Then, we cover Dr Rita Levi-Montalcini whose bedroom experiments won her the Nobel Prize.We hear from a man who worked on the Mont Blanc Tunnel, which opened in 1965.A survivor describes Florence's devastating flood in 1966. Finally, the story of how the actress Gina Lollobrigida interviewed Cuba's leader Fidel Castro.Contributors:Fran Tomasi and Andrea Pattaro - witnesses to Pink Floyd's Venice concert.Arusa Qureshi - Scottish writer, editor and music programmer.Franco Cuaz - Mont Blanc Tunnel's first operations manager.Antonina Bargellini - survivor of the Florence flood.(Photo: Pink Floyd performing in Venice. Credit: Andrea Pattaro)

Hey kooks! Your lovable scientists are back, and they're vying for a Nobel Prize (they'll take any one of them) while tackling an extremely relatable whatado from a 23 year old “shy introvert” in San Francisco asking for newbie dating advice. Jess and Caroline insist that being charismatic isn't the only way to stand out on the dating scene and wax poetic about the value of being courageous.Then Jess tells us all about a new challenge she accepted and its profound healing effect. And Caroline reflects on her own relationship to fear. The whole conversation leads these two to reflect on the beauty of their partnership and this very podcast's beginnings. If that wasn't enough, tune in for a choice movie rec and the secret skill Jess reveals from her past!This episode was produced by Kasia Houlihan (⁠cargocollective.com/kasiahoulihan⁠).___Share with a friend!Follow, rate, and review on your favorite podcasting app!Subscribe on YOUTUBE for full episode video:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@Not4EveryonePod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Plus follow us on INSTAGRAM for more:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@not4everyonepod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@thegoodsitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jzdebakey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You can DM us there or submit topics for an upcoming episode to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠not4everyonepod@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.And don't forget about our APPAREL:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠nfepodapparel.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠__Intro Music: “Doja Dance” by PALA__DISCLAIMER: All opinions are our own. We are not therapists or health professionals, or professional of any kind, really. Please see your own professional or counselor for professional support. Do your research and be safe!

This week The JCW show crew talk new allegations against Trump, Tony Romo's father tells us about his sons paper route, we debut a new song from Nobel Prize winner Bob Dylan & MUCH MUCH MORE!

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We all love the thrill of winning - the house, the promotion, the deal. But as Nobel laureate Richard Thaler explains, some of our biggest “wins” are actually the moments we set ourselves up to lose. Thaler breaks down why we overbid, overpay, and talk ourselves into choices we regret. And he shares simple tricks to help you catch yourself before you make a mistake you can't undo.

During World War Two, Italian scientist Dr Rita Levi-Montalcini was forced to do experiments in her bedroom after being banned from universities because she was Jewish. Her experiments in that bedroom laboratory on chicken embryos led to the discovery of nerve cell death. Whilst working in the United States after the war, she worked out that a protein factor was required for the growth of our nerves. A discovery which won her the Nobel Prize in physiology in 1986. Her work improved our understanding of the nervous system and has allowed scientists to potentially battle degenerative diseases such as dementia. Produced and presented by Tim O'Callaghan, using archive interviews from the Nobel Prize Institute, the Society for Neuroscience and the BBC Archives. Eye-witness accounts brought to life by archive. Witness History is for those fascinated by the past. We take you to the events that have shaped our world through the eyes of the people who were there. For nine minutes every day, we take you back in time and all over the world, to examine wars, coups, scientific discoveries, cultural moments and much more. Recent episodes explore everything from the death of Adolf Hitler, the first spacewalk and the making of the movie Jaws, to celebrity tortoise Lonesome George, the Kobe earthquake and the invention of superglue. We look at the lives of some of the most famous leaders, artists, scientists and personalities in history, including: Eva Peron – Argentina's Evita; President Ronald Reagan and his famous ‘tear down this wall' speech; Thomas Keneally on why he wrote Schindler's List; and Jacques Derrida, France's ‘rock star' philosopher. You can learn all about fascinating and surprising stories, such as the civil rights swimming protest; the disastrous D-Day rehearsal; and the death of one of the world's oldest languages.(Photo: Dr Rita Levi-Montalcini in 1950. Mondadori via Getty Images)

In this interview episode, we are joined by physicists Sam Gregson (Bad Boy of Science YouTube channel) and Tim Henke to examine the rise of science populism: a style of science communication that borrows the tactics of political populism, including grievance narratives, institutional distrust, and conspiratorial framing, while presenting its advocates as lone truth-tellers battling a corrupt academic elite.We discuss how DTG favourites like Sabine Hossenfelder and Eric Weinstein, as well as fresh new faces Brian Keating and Avi Loeb, deploy selective truths about physics to fuel self-aggrandising, anti-expert narratives.Along the way, we also cover stuff like why “physics hasn't progressed in 50 years”, cranks are useful props for populist arguments, and the strange obsession with Nobel Prizes.If you are interested in guru dynamics, science communication, and physics crankery, this might be an episode for you.LinksBad Boy of Science (Sam Gregson)Tim's Profile WebsiteBad Boy of Science – The Rise of Physics PopulisersTheories of Everything (Kurt Jaimungal)Losing the Nobel Prize – Brian KeatingInto the Impossible (Brian Keating)Sabine Hossenfelder's YouTube ChannelThe Portal (Eric Weinstein)The Galileo Project (Avi Loeb)Sean Carroll – Mindscape / Preposterous UniverseNot Even Wrong (Peter Woit)

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. This episode breaks down what that molecule is, why it works, and how it may upgrade mitochondria, sleep, and human performance when used correctly. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Chris Burres, founder and chief scientist of MyVitalC and the original long-term manufacturer of carbon 60. Chris has produced this Nobel Prize–winning molecule since the early 1990s, supplying research institutions around the world years before it ever entered the biohacking space. He explains how carbon 60 behaves differently from traditional antioxidants, why stability and concentration used to be major problems, and how modern manufacturing finally made real-world use possible. Chris is also a published author, longevity summit host, patent holder, and longtime science communicator who brings rare clarity and humor to complex biology. Dave and Chris explore how carbon 60 interacts with mitochondria, oxidative stress, metabolism, and electrical signaling in the body, and where it fits alongside ketosis, nootropics, supplements, and functional medicine strategies. They also unpack why improving mitochondrial function often shows up first as better energy and sleep optimization, and how that foundation supports longevity, brain optimization, and Smarter Not Harder performance. Along the way, Dave shares his own early experience with C60, how he uses it today, and why it now shows up even in his Danger Coffee stack. You'll Learn: • Why carbon 60 produced the longest longevity result ever recorded in mammal studies • How mitochondrial efficiency shapes energy, sleep, and human performance • What makes C60 a selective antioxidant instead of a blunt one • Why purity, concentration, and stability determine whether a supplement works • How carbon 60 fits into biohacking stacks built around ketosis and metabolism • What users report first, from focus and resilience to deeper sleep • Why mitochondrial health underpins long-term anti-aging strategies • How to think about supplements through a Smarter Not Harder lens Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Affiliates: Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: carbon 60 podcast, C60 longevity science, biohacking mitochondria, mitochondrial optimization podcast, anti-aging supplements science, human performance longevity, selective antioxidant mitochondria, sleep optimization biohacking, brain optimization supplements, nootropics longevity stack, ketosis metabolism longevity, functional medicine mitochondria, oxidative stress longevity, carbon 60 supplement science, MyVitalC podcast, Chris Burres interview, Dave Asprey biohacking, Danger Coffee stack, Smarter Not Harder longevity, Nobel Prize molecule longevity, mitochondrial health podcast Resources: • Get a 30% discount on your next purchase of ESS60 at: https://www.myvitalc.com/pages/humanupgradeod?ref=humanupgrade • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Introduction & C60 Discovery 4:04 – The Molecule & Nobel Prize 8:27 – Quantum Properties & Superconductivity 11:16 – Rat Longevity Study Results 14:33 – Selective Antioxidant Properties 15:51 – User Experience & Timeline 18:15 – Biological Age Testing 21:33 – Why Oil & Product Development 23:32 – Mechanism of Action 28:13 – Biohacker Discovery Story 30:03 – FDA & Supplement Regulation 33:50 – Migraines & Clinical Observations 37:53 – Athletic Performance 40:43 – Stacking & Contraindications 45:57 – Skincare Product 50:43 – Who Benefits Most 1:00:37 – Mitochondria & Consciousness 1:02:03 – Where to Buy & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.