Podcasts about Quercetin

In this episode Dr Sarah Howard discusses healthy ageing in dogs with Dr Matthew Muir. Topics discussed include: The reason ageing is currently a hot topic. What leads to an increased lifespan and better quality of life? Diet changes that can impact ageing in dogs. Dr Muir discusses what we should avoid in order to increase lifespan. Matthew goes into details of what dogs' diets should look like to prevent disease. How often should we be feeding our pets? What happens to the gut microbiome as dogs get older? Dr Muir delves into supplements that can be beneficial for ageing and emerging tools that are becoming available. The importance of preventative medicine - proactive vs reactive care. Accelerators of biological ageing. Additional resources: https://pubmed.ncbi.nlm.nih.gov/11991408/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11675035/https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1355560/full https://pmc.ncbi.nlm.nih.gov/articles/PMC11505706/ https://www.mdpi.com/1660-3397/18/11/564https://pmc.ncbi.nlm.nih.gov/articles/PMC4936929/ https://pubmed.ncbi.nlm.nih.gov/22216092/ Adams VJ, Watson P, Carmichael S, Gerry S, Penell J, Morgan DM. Exceptional longevity and potential determinants of successful ageing in a cohort of 39 Labrador retrievers: results of a prospective longitudinal study. Acta Vet Scand. 2016;58:29. doi:10.1186/s13028-016-0204-8 Cupp CJ, Jean-Philippe C, Kerr WW, Patil AR. Effect of nutritional interventions on longevity of senior cats. Int J Appl Res Vet Med. 2007;5(3):133–149 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Jackson J, Radford AD, Belshaw Z, Wallis LJ, Kubinyi E, German AJ, Westgarth C. Using veterinary health records at scale to investigate ageing dogs and their common issues in primary care. J Small Anim Pract. 2025;66(2):81–91. doi:10.1111/jsap.13809 Creevy KE, O'Neill DG, Promislow DEL. Morbidity and mortality in elderly dogs – a model for human aging. BMC Vet Res. 2022;18(1):456. doi:10.1186/s12917-022-03518-8 Lewis TW, Wiles BM, Llewellyn-Zaidi AM, Evans KM, O’Neill DG. Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014. Canine Genet Epidemiol. 2018;5:10. doi:10.1186/s40575-018-0066-8 Kealy RD, Lawler DF, Ballam JM, Mantz SL, Biery DN, Greeley EH, Lust G, Segre M, Smith GK, Stowe HD. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc. 2002;220(9):1315–1320. doi:10.2460/javma.2002.220.1315 Guelfi G, Capaccia C, Tedeschi M, Bufalari A, Leonardi L, Cenci-Goga B, Maranesi M. Dog aging: a comprehensive review of molecular, cellular, and physiological processes. Cells. 2024;13(24):2101. doi:10.3390/cells13242101 Laflamme DP. Nutritional care for aging cats and dogs. Vet Clin North Am Small Anim Pract. 2012;42(4):769–791. doi:10.1016/j.cvsm.2012.04.002 Hall JA, Jewell DE. Feeding healthy beagles medium-chain triglycerides, fish oil, and L-carnitine offsets age-related changes in serum fatty acids and carnitine metabolites. PLoS One. 2012;7(11):e49510. doi:10.1371/journal.pone.0049510 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Bray EE, Zheng Z, Tolbert MK, McCoy BM, Kaeberlein M, Kerr KF; Dog Aging Project Consortium. Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project. GeroScience. 2022;44(3):1779–1790. doi:10.1007/s11357-022-00575-7 Palaseweenun P, Hagen‐Plantinga EA, Schonewille JT, Koop G, Butre C, Jonathan M, Wierenga PA, Hendriks WH. Urinary excretion of advanced glycation end products in dogs and cats. J Anim Physiol Anim Nutr (Berl). 2021;105(1):149–156. doi:10.1111/jpn.13347 Yang L, Yang L, Cai Y, Luo Y, Wang H, Wang L, Chen J, Liu X, Wu Y, Qin Y, Wu Z, Liu N. Natural mycotoxin contamination in dog food: a review on toxicity and detoxification methods. Ecotoxicol Environ Saf. 2023;257:114948. doi:10.1016/j.ecoenv.2023.114948 Bridglalsingh S, Archer-Hartmann S, Azadi P, Barbier de La Serre C, Remillard RL, Sunvold GD, Bartges JW. Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs. J Anim Physiol Anim Nutr (Berl). 2024;108(3):735–751. doi:10.1111/jpn.13927 Marchi PH, Vendramini THA, Perini MP, Zafalon RVA, Amaral AR, Ochamotto VA, Da Silveira JC, Dagli MLZ, Brunetto MA. Obesity, inflammation, and cancer in dogs: review and perspectives. Front Vet Sci. 2022;9:1004122. doi:10.3389/fvets.2022.1004122 Schmid SM, Hoffman JM, Prescott J, Ernst H, Promislow DEL, Creevy KE; Dog Aging Project Consortium. The companion dog as a model for inflammaging: a cross-sectional pilot study. GeroScience. 2024;46(6):5395–5407. doi:10.1007/s11357-024-01217-w Ren J, Li H, Zeng G, Pang B, Wang Q, Wei J. Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? Front Pharmacol. 2023;14:1178596. doi:10.3389/fphar.2023.1178596 Parker A, Romano S, Ansorge R, Aboelnour A, Le Gall G, Savva GM, Pontifex MG, Telatin A, Baker D, Jones E, Vauzour D, Rudder S, Blackshaw LA, Jeffery G, Carding SR. Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. Microbiome. 2022;10:68. doi:10.1186/s40168-022-01262-3 Ulluwishewa D, Anderson RC, McNabb WC, et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141(5):769–76. doi:10.3945/jn.110.135657 Cao L, Lee SG, Lim KT, Kim HR. Potential anti-aging substances derived from seaweeds. Mar Drugs. 2020;18(11):564. doi:10.3390/md18110564 Grzeczka A, Graczyk S, Kordowitzki P. Pleiotropic effects of resveratrol on aging-related cardiovascular diseases—what can we learn from research in dogs? Cells. 2024;13(20):1732. doi:10.3390/cells13201732 Kusaba A, Arai T. Shiitake mushroom powder supplementation increases antioxidative activity in dogs. Front Vet Sci. 2024;11:1355560. doi:10.3389/fvets.2024.1355560 Cho HW, Choi S, Seo K, Kim KH, Jeon JH, Kim CH, Lim S, Jeong S, Chun JL. Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus. J Anim Sci Technol. 2022 Sep;64(5):937-949. Kaur J, Seshadri S, Golla KH, Sampara P. Efficacy and safety of standardized ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial. J Vet Behav. 2022;51:8–15. Bharani KK, Devarasetti AK, Carey L, Khurana A, Kollipaka R, Hanuman DDV, Chetla VS, Banothu AK. Effects of ashwagandha (Withania somnifera) root extract on aging-related changes in healthy geriatric dogs: A randomized, double-blinded placebo-controlled study. Vet Med Sci. 2024 Sep;10(5):e1556 Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. Gut-brain axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine. Vet Med Int. 2024;2024:2856759. doi:10.1155/2024/2856759 Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024;16(4):3088–3106. doi:10.18632/aging.205581 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife. 2016;5:e16351. doi:10.7554/eLife.16351 Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience. 2017;39(2):117–127. doi:10.1007/s11357-017-9972-z Kaeberlein M, Creevy KE, Promislow DEL. The Dog Aging Project: translational geroscience in companion animals. Mamm Genome. 2016;27(7–8):279–288. doi:10.1007/s00335-016-9638- Mulder IE, Schmidt B, Lewis M, Delday M, Stokes CR, Bailey M, Aminov RI, Gill BP, Pluske JR, Mayer CD, Kelly D. Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity. PLoS One. 2011;6(12):e28279. doi:10.1371/journal.pone.0028279 Hemida M, Vuori KA, Moore R, Anturaniemi J, Hielm-Björkman A. Early life modifiable exposures and their association with owner-reported inflammatory bowel disease symptoms in adult dogs. Front Vet Sci. 2021;8:552350. doi:10.3389/fvets.2021.552350 McMahon JE, Graves JL, Tovar AP, Peloquin M, Greenwood K, Chen FL, Nelson M, McCandless EE, Halioua-Haubold CL, Juarez-Salinas D. Translational immune and metabolic markers of aging in dogs. Sci Rep. 2025;15:14460. doi:10.1038/s41598-025-51976-3 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Santos JDP, Cunha E, Nunes T, Tavares L, Oliveira M. Relation between periodontal disease and systemic diseases in dogs. Res Vet Sci. 2019;125:136–140. doi:10.1016/j.rvsc.2019.05.011 Selting KA, Ringold R, Husbands B, Pithua PO. Thymidine kinase type 1 and C-reactive protein concentrations in dogs with spontaneously occurring cancer. J Vet Intern Med. 2016;30(4):1159–1166. doi:10.1111/jvim.13954 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Clark JD, Rager DR, Crowell-Davis S, Evans DL. Housing and exercise of dogs: effects on behaviour, immune function and cortisol concentration. Lab Anim Sci. 1997;47(5):500–510 See omnystudio.com/listener for privacy information.

As consumer wearables track everything from our heartbeats to nightly sleep cycles, a new industry has emerged—one focused on making sense of this avalanche of personal health data. In an era when prevention is prized over cure, questions abound: How accurate is the data captured on our wrists and fingers? Can these metrics truly guide us to longer, healthier lives, or are we just generating noise? For Marco Benitez, a biomedical engineer and co-founder of the health data platform Rook, the challenge isn't just about collecting the numbers but turning them into actionable insights—for both individuals and the broader healthcare world. As the medical establishment wrestles with integrating this torrent of information—and as users grapple with privacy and security—a revolution in health is quietly unfolding. Peter Bowes sat down with Benitez to discuss the promise and pitfalls of wearable data, the evolving relationship between Big Pharma and digital health, and what it will take to shift the system from sick care to prevention.___If you value our video and audio content, we would appreciate your support.Any contribution - large or small - is hugely appreciated and helps us to continue sharing insights that could help us all live longer and healthier lives. With gratitude. https://www.buzzsprout.com/87724/support PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Dr Steve, Dr Scott, and Lady Diagnosis discuss: What are Quercetin and Zinc used for? Can you use vascepa prophylactically? Quinine pills for leg cramps? Why was it banned by the FDA? A challenging hip pain and more Please visit: ⁠⁠⁠⁠simplyherbals.net/cbd-sinus-rinse⁠⁠⁠⁠ (the best he's ever made. Seriously.) ⁠⁠⁠⁠instagram.com/weirdmedicine⁠⁠⁠⁠ ⁠⁠⁠⁠x.com/weirdmedicine⁠⁠⁠⁠ ⁠⁠⁠⁠stuff.doctorsteve.com⁠⁠⁠⁠ (it's back!) ⁠⁠⁠⁠youtube.com/@weirdmedicine ⁠⁠⁠⁠(click JOIN and ACCEPT GIFTED MEMBERSHIPS. Join the "Fluid Family" for live recordings!) ⁠⁠⁠⁠youtube.com/@normalworld ⁠⁠⁠⁠(Check out Dave and crew, and occasionally see your old pal!) supertip.gg/drsteve (make your pals say awful things through the magic of AI) CHECK OUT THE ROADIE COACH stringed instrument trainer! ⁠⁠⁠⁠roadie.doctorsteve.com⁠⁠⁠⁠ (the greatest gift for a guitarist or bassist! The robotic tuner!) see it here: ⁠⁠⁠⁠stuff.doctorsteve.com/#roadie⁠⁠⁠⁠ Also don't forget: ⁠⁠⁠⁠Cameo.com/weirdmedicine⁠⁠⁠⁠ (Book your old pal right now because he's cheap! "FLUID!") Most importantly! ⁠⁠⁠⁠CHECK US OUT ON PATREON! ⁠⁠⁠⁠ ALL NEW CONTENT! Robert Kelly, Mark Normand, Jim Norton, Gregg Hughes, Anthony Cumia, Joe DeRosa, Pete Davidson, Geno Bisconte, Cassie Black ("Safe Slut"). Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Future nutrition should be personalized, with artificial intelligence as a key driver, according to Melissa Snover, founder of Nourished, a UK-based company that makes 3D-printed gummy vitamin and supplement stacks.  She believes the current approach to supplementation and health products is outdated and poorly tailored to individual needs. Snover, registered dietitian, joined us to discuss the burgeoning field of precision nutrition. Nourished uses AI-powered algorithms to create customized nutrient gummies, based on users' lifestyle data and health goals—an approach she says offers a significant leap beyond the traditional "one size fits all" vitamin regime.  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

In this encore episode, we highlight the role of vitamin B1 (thiamine) in supporting gastrointestinal function, focusing on intestinal motility while detailing vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) may further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert to regulate microbial balance in the small intestine. Topics: 1. Introduction- Focus on SIBO, intestinal motility, and vitamin B1 (thiamine)  2. Small Intestine and Microbial Regulation- Low bacterial load under healthy conditions  - Protective mechanisms: gastric acid, enzymes, motility…   3. Overview of SIBO Subtypes - H₂-SIBO, hydrogen-producing bacteria  - IMO, methane-producing archaea  - H₂S-SIBO, hydrogen sulfide-producing bacteria  - Subtypes can coexist, share underlying factors   4. Host Factors in Microbial Regulation - Gastric acid, motility, pancreatic enzymes, bile acids, and immune surveillance  5. Gastric Acid and Parietal Cells  - Hydrochloric acid and intrinsic factor  - Acid environment supports digestion and microbial regulation  - Protein denaturation and pepsin activation 6. Chief Cells and Enzyme Function - Pepsinogen and gastric lipase  - Pepsinogen activated by acidic pH   7. Hypochlorhydria and Downstream Effects 8. Pancreatic Enzymes in the Small Intestine   9. Intestinal Motility and the Enteric Nervous System (ENS)- Coordinated smooth muscle contractions  - Myenteric and submucosal plexuses   10. Intestinal Wall Anatomy - Epithelium and lamina propria - Submucosa contains the submucosal plexus  - Myenteric plexus located between muscle layers   11. Vitamin B1 (Thiamine) and Gastrointestinal Function  - Acetylcholine synthesized from choline and acetyl-CoA  - Acetyl-CoA formation, thiamine availability  - Acetylcholine signaling  12. SIBO and Nutrient Availability- Bacterial overgrowth can affect nutrient absorption  - Thiaminases   13. Conclusion  - Root cause approach, multi-factorial Thank you to our episode sponsor: 1. ⁠⁠OmneDiem®'s⁠⁠ ⁠⁠Histamine Digest®⁠⁠ and ⁠⁠Histamine Digest® PureMAX⁠⁠ 2. ⁠⁠Histamine Digest® Histamine Complete⁠⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in conditions such as small intestinal bacterial overgrowth (SIBO).Topics:1. Hypochlorhydria - Low stomach acid.- Aging, autoimmune gastritis, chronic PPI use, H. pylori infection.2. H. pylori - Common gram-negative bacterium that colonizes the stomach lining.- Symptoms.- Produces urease.- Ammonia neutralizes acid, creating a protective microenvironment.- Additional virulence factors and ability to form biofilms contribute to persistence.3. Gastric Anatomy & Layers- The stomach: hollow, muscular organ for mechanical and chemical digestion.- Regions: Cardia, fundus, body, and pylorus.- Layers: Mucosa, Submucosa, Muscularis externa, Serosa4. Mucosal Layer - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.- Gastric pits lead to gastric glands, which contain specialized secretory cells.5. Specialized Gastric Cells- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.- Intrinsic factor and vitamin B12 absorption.6. Vitamin B12 Absorption- Essential for DNA synthesis, RBC formation, neurological function.- Released from food proteins by gastric acid and pepsin.- Impaired absorption.7. Role of Gastric Acid in Broader Micronutrient Absorption- Absorption of minerals.- Soluble, ionized state.- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.8. Protective Role of Gastric Acid- Acts as a line of defense against ingested pathogens.- Maintains low microbial diversity in the stomach.- Low HCl and SIBO (Small Intestinal Bacterial Overgrowth).9. Symptoms of Low Stomach Acid- Bloating, early satiety, excessive belching.- Undigested food in stool, chronic constipation.- May reflect impaired enzymatic activation and digestive insufficiency.10. Conclusion- Multifactorial causes and downstream effects.- Optimal range of stomach acid: neither high nor low.Thank you to our episode sponsor: 1. ⁠OmneDiem®'s⁠ ⁠Histamine Digest®⁠ and ⁠Histamine Digest® PureMAX⁠ 2. ⁠Histamine Digest® Histamine Complete⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Today, I'm welcoming back Dr. Jeffrey Gross, a true pioneer in the regenerative longevity space. You might remember our earlier episode where we explored the transformative science of human exosomes—but today, we're going even further, straight into the fascinating world of plant exosomes.   What we discuss: Plant exosomes intro ... 00:04:23 Gut health/minerals ... 00:05:18 Why plant exosomes ... 00:08:09 Exosomes vs. liposomes ... 00:09:35 Bioavailability ... 00:12:12 Phytonutrients ... 00:17:26 Resveratrol ... 00:18:17 Quercetin ... 00:20:30 Glutathione ... 00:22:01 Antioxidant enzymes ... 00:24:02 Fruit yield per cap ... 00:25:32 Melatonin ... 00:26:55 Oral bioavailability ... 00:29:29 Research summary ... 00:30:10 Sirtuin 1/ROS ... 00:31:29 Prepping for joint regen ... 00:42:05 Cartilage success ... 00:44:00 European edge ... 00:47:48 B vitamins ... 00:48:25 Microbiome ... 00:51:50 Fisetin/dosing ... 00:53:22   Our Amazing Sponsors: Mimio - A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order. BEAM Minerals - are one of the most overlooked contributors to a healthy gut. They help feed and support your microbiome. Research shows that good gut bacteria rely on essential minerals like calcium, magnesium, zinc, iron, and phosphorus to thrive.. Head over to www.beamminerals.com and use code NAT20 for 20% off your first order and give your gut the simple support it deserves! Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

While most people regularly check their blood pressure or glucose, few consider routinely assessing their body's ability to move—and yet, this may be just as crucial to long-term health. Andrew Menter, CEO of Physmodo, joined Peter Bowes to explore the software company's mission to raise the profile of movement as a vital sign of good health. Andrew shares his personal journey from a career in law and finance to entrepreneurship in movement science, motivated in part by his athletic pursuits and the injuries that accompanied them. He discusses Physmodo's innovative use of computer vision technology, enabling self-assessment of mobility and posture via simple smartphone or tablet tools—making this once-specialized information accessible to everyone, not just elite athletes. He highlights the power of early intervention, the surprising ways movement influences sleep and mental health, and the growing importance of personalized preventive care.  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

In this episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, reduced pancreatic enzyme and bile output, impaired motility, diminished commensal bacterial populations, and weakened mucosal immunity.Topics: 1. Introduction- Focus on the gut mucosal barrier.- Emphasis on Small Intestinal Fungal Overgrowth (SIFO) and biofilms.2. Intestinal Barrier Anatomy- The mucosa: epithelium, lamina propria, and a thin band of smooth muscle.- The epithelial layer.- Covered by protective mucus composed of mucin glycoproteins secreted by goblet cells.- In the small intestine: less dense mucus.3. Epithelial Integrity- Tight junctions.- Paracellular barrier preventing uncontrolled antigen passage.4. Lamina Propria5. Overview of Small Intestinal Fungal Overgrowth (SIFO)- SIFO involves fungal overgrowth in the small intestine, commonly Candida species.- Small intestines: Low microbial density due to motility, gastric acid, bile acids, immune surveillance, and more.- Contributing factors: hypochlorhydria, impaired motility, reduced digestive enzymes, diminished competitive flora, lowered immunity, and more.6. Candida Pathogenicity- Candida exhibits phenotypic plasticity: yeast and hyphal forms.- Biofilm formation.7. Biofilm Formation- Biofilms are structured communities of microbes within a self-produced extracellular matrix.- Resistance to antimicrobials and immune defenses.- Can develop on intestinal mucosa and in various other regions.8. SIFO and SIBO Overlap- Root causes and overlap between SIFO and Small Intestinal Bacterial Overgrowth (SIBO).- Common symptoms.9. Gastric Acid in More Detail- Stomach epithelium includes mucous, parietal, chief, and enteroendocrine cells- Parietal cells secrete hydrochloric acid.- HCl denatures proteins and aids in inhibiting pathogens.- Hypochlorhydria: possible causes. 10. Downstream Effects of Low Acid11. Gut Motility in More Detail- Motility involves rhythmic smooth muscle contractions.- Enteric nervous system (ENS): myenteric and submucosal plexuses.- Dysautonomia and motility.12. SIFO Contributing Factors13. Candida Regulation- Candida generally remains in unicellular yeast form under homeostatic regulation.- Controlled by microbial competition, host defenses, antifungal peptides, and more.14. Role of Mucus and sIgA- Mucosal immunity (including sIgA) aids in regulating Candida populations.- Low sIgA levels (due to stress, immune suppression, dysbiosis,…) weaken defense 15. Conclusion- Mucosal barrier structure.- SIFO and Candida.- Biofilm formation, microbial persistence, and mucosal disruption.- SIFO and SIBO.- Multifactorial nature of fungal dysbiosis, types of biofilms, and small intestinal overgrowth.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Today I'm happy to chat with our patient Leslie who shares her successful journey with histamine intolerance healing. We'll go through how SIBO led to her histamine issues, the connection to low vagus nerve tone, as well as the low histamine diet and treatments such as dao enzymes. Tune in to learn how you can reduce histamine in the body naturally.    Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/ Histamine Intolerance and Diet Guide: https://drruscio.com/guides/get-histamine-intolerance-guide/  

Nutritionist Leyla Muedin explores the significance of detoxification and its impact on overall health. She highlights the role of the liver in detoxification and discusses how various foods and nutrients can support liver function to optimize detoxification pathways. Leyla covers the importance of consuming organic produce, clean seafood, and minimizing exposure to toxins found in household products, medications, and certain foods. She also details the phase one and phase two enzymes involved in detoxification, the importance of specific vitamins, minerals, and amino acids, and the signals that might indicate the need for liver support. Lastly, she encourages listeners to make healthier dietary choices and lifestyle changes to support their liver and overall well-being.

 Immune Health and Allergies ..think 5 in 1 Qummune for Year round support!Flavonoids..... Let's start with one that is classified as a Flavonoid, and thatis Quercetin.We also dive into Liposomal delivery,Do you have allergies and immune issues?  → Can Quercetin be found in food?→ What is the difference between Quercetin & Quercetin Phytosome?→ What are branded ingredients? → Vitamin C is also a go to for people hoping to supportdaily Immune function. But not all Vitamin C is the same.→ Zinc rich foods people can add in? → D3/K2-Why should they be taken together??→ Absorption seems to be the key whether it be food or Supplements.→ Lab tested and certified for potency and purity. Why isthis important?Guest: Amber Lynn Vitale, CN is Board Certified in Holistic Nutrition®and a Certified Dietary Supplement Professional™. She is also anAyurvedic Clinical Consultant on faculty with Wild Rose College ofHerbal Medicine, and on the advisory board for Natural Practitionerand Taste for Life magazines.Amber's journey in the healing arts developed richly as she workedfor years in practices with Integrative Physicians, Acupuncturists,Chiropractors, and Nurses. Since 2008 she has been producingwritten and video educational content for many publications, aneducational YouTube channel, and Instagram and Facebook pages.By 2012 she had realized that raw materials sourcing, labelingtransparency, legitimate certifications, and educational supportwere the criteria that would set quality natural products brandsapart from the rest; and she made it her mission to educateboth the practitioner and the public about the standards thatensure a reliable product.  Recently she founded Trifecta ForHealth, LLC using her years of experience to develop synergistichealth protocols tailored to individual needs, and provide brandsupport for the best supplemental products currently available.Learn more about Amber  Learn More about Qummune 5 in 1 Immune Support (Use the code Forever25 to save 25% OFF)  Read the research

Mastzellen sind die Türsteher unseres Immunsystems. Immer mehr Menschen leiden unter dem Mastzellenaktivierungssyndrom MCAS: Das macht die Türsteher hypernervös, lässt sie harmlose Gäste anbrüllen und in den Club kotzen. Wie beruhigen wir die Kerle?   Bei Omega 3 mögen wir EPA und DHA im Verhältnis 1:1. Dazu geht man bei Norsan-Produkten so vor, wir haben's für euch ausgerechnet: Man nimmt das Omega-3 Total Öl, das gibt es hier. Variante 1: Man mischt es im Mengenverhältnis 2:5 (oder für die, die es ganz genau wissen möchten: 9:22) mit Omega-3 Arktis, das gibt es hier. Variante 2: Man mischt es im Mengenverhältnis 2:1 mit Omega-3 Vegan, das gibt es hier. Sehr viel einfacher ausrechnen lässt sich folgendes: 15% Rabatt gibt's bei der ersten Norsan-Bestellung mit dem Code „biohacker15“.   Gute Vitamin D3/K2-Produkte sind zum Beispiel dieses, dieses und dieses.   Vitamin C retard gibt es zum Beispiel hier und hier.   Ein gut verträgliches Vitamin C gibt's hier.   Quercetin gibt es hier.   ECGC (Grüntee-Extrakt) gibt es hier und hier.   Ein sehr gutes Kurkumin-Produkt ist dieses.   Bromelain gibt es hier und hier.   Ordentliches NAC gibt's hier.   Das erwähnte Buch „Mastzellenfreundliche und histaminarme Küche“ gibt es hier.   Glutamin gibt's hier. Zum Vitus Handkühler geht es hier.   Eine gute Quelle für Rhodiola Rosea ist diese.   Hochwertiges Ashwagandha gibt es hier.   Daosin gibt es hier.   Zu Panifactum geht es hier.   Der Mastzellen-modulierende Wirkstoff Cromoglicinsäure ist in mehreren Arzneimitteln enthalten, zum Beispiel diesem, diesem, diesem, diesem, diesem und diesem.   Der Mastzellen-modulierende Wirkstoff Ketotifen ist in mehreren Arzneimitteln enthalten, zum Beispiel in diesem und diesem. Weil Andreas Breitfeld und Stefan Wagner so häufig gefragt werden, welche Produkte sie selbst verwenden, haben sie gemeinsam mit Julia Tulipan diese Seite eingerichtet, auf der sie ihre persönlichen Lieblingsprodukte (und aktuelle Rabattcodes) sammeln.   Das Buch „Ab jetzt Biohacking“ von Andreas Breitfeld und Stefan Wagner ist beim Ecowing-Verlag erschienen. Bestellen kann man es zum Beispiel hier.   Das Buch „Viel Erfolg beim Misserfolg“ ist der Biohacking-Business-Ratgeber von Stefan Wagner, erschienen im Seifert Verlag, erhältlich hier.   Zur Website von Andreas Breitfeld geht es hier.   Wie Andreas Breitfeld und Stefan Wagner einander kennen gelernt haben? Stefan hat über Andreas ein Porträt für The Red Bulletin verfasst. Nachzulesen ist das hier.   Andreas Breitfeld und Stefan Wagner haben gemeinsam für The Red Bulletin INNOVATOR ein Biohacking-Spezialheft verfasst. Das ist hier zu finden.   Stefan Wagners Biohacking-Kolumne für „carpe diem“ ist hier nachzulesen.

Onion juice is a natural hair loss remedy for many different types of hair loss. Whether autoimmune, nutritional, or fungal, onion juice can help stop hair loss naturally and stimulate natural hair growth quickly. Onions are loaded with sulfur, an essential building block for keratin, the protein that builds your hair. Onions have a high amount of quercetin, which is beneficial for autoimmune hair loss cases caused by alopecia. Quercetin helps increase the growth hormones of the hair follicle. It's also a powerful antimicrobial, so it can help protect the scalp against the overgrowth of yeast, fungus, and mold. To use onion juice for hair growth, chop one red onion and blend it in a blender. Put the blended onion through a cheesecloth to separate the liquid from the pulp. Massage the liquid into your scalp for a few minutes in the shower. Don't rinse! Allow the onion juice to sit in your hair for 30 minutes to 1 hour.Rinse your hair and shampoo twice to remove onion odor. Do this twice per week for 4 to 6 weeks. You should notice hair growth after week 3 or 4!To increase the benefits of onion juice for hair, add 5 drops of rosemary oil. In a 2015 randomized trial, rosemary oil was found to be as effective as one of the top medications for alopecia. Rosemary oil has several anti-inflammatory and antioxidant phytonutrients that increase blood flow to the scalp.While onion juice for hair has been proven effective, fermenting it can increase its effectiveness! To do this, combine onion juice, 8 ounces of water, a teaspoon of sea salt, and a ½ teaspoon of raw honey in a glass or mason jar.Cover the mixture with a cheesecloth and allow it to ferment at room temperature for 72 hours. This enhances the quercetin in the onion juice, increasing hair growth. Put the mixture through a cheesecloth to separate the liquid.If you're experiencing hair loss, taking 10,000 to 20,000 IU of vitamin D daily is very beneficial. A healthy diet is also imperative!Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

Abbie Smith-Ryan PhD, an expert in exercise and nutritional strategies for women's health, especially during perimenopause, menopause and obesity, discusses evidence-based methods to accelerate fat loss, increase muscle mass, and improve well-being and longevity for women. Topics include accurate body composition measurement, the role of protein and fibre, optimizing pre- and post-exercise fueling, metabolic adaptation, and supplements like Omega-3s, vitamin D, magnesium, and creatine. Dr. Smith-Ryan also stresses consistent, varied exercise routines and mental and physical recovery.Episode Overview (timestamps are approximate):(0:00) Intro/Teaser(11:00) Nutrition for Body Recomposition(22:00) Nutrient Timing Pre and Post Exercise(32:00) Protein Intake for Women(43:00) The Benefits of Inefficiencies(48:00) Optimal Exercise Frequency and Variety(56:00) Key Supplements for Women's Health(1:05:00) Optimizing Perimenopause Nutrition & Recovery(1:12:00) The “After Party” with Dr. StephanieResources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep418/A huge thanks to our sponsors:TIMELINE - Improve energy at the cellular level with Mitopure. Save 10% at https://timelinenutrition.com/better with code BETTER.ONESKIN  - Use the power of peptides for firmer, glowing skin. Save 15% at https://oneskin.co/better with code BETTER.LVLUP - Midlife hormonal changes can wreak havoc on your gut health. Ultimate GI Repair combines powerful gut-healing peptides BPC-157, Larazotide Acetate and KPV with gut-nourishing naturals like Zinc L-Caronsine, EMIQ, Quercetin and Tributyrin to soothe your changing digestion. To learn more, visit https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% off.BODYBIO - Support your health with Fish Oil Plus. Great straight or in smoothies! Use code BETTER at https://bodybio.com/better for 15% off.

An episode from The Holistic Navigator. This is not to diagnosis or treat any disease/illness. Consult your physician before taking supplements or medications OR before you stop taking medications. This is for entertainment/informational purposes only! Quercetin is a funny sounding nutrient that isn't joking around. It's an antioxidant that's found in plants that is most often associated with sinus and allergy support, but it's a powerhouse that should be considered as a daily supplement. From athletes, allergy sufferers, or anyone exposed to respiratory stressors, quercetin is a wonderful supplement with a plethora of benefits. Meet John Mills: On this week's episode we speak with John Mills, Director of Quality and Compliance at Highland Laboratories in Mt. Angel, Oregon. John walks us through an overview of the general benefits and then looks at a specific quercetin formulation from Mt. Angel Vitamins that includes Zinc, Bromelain, Stinging Nettles, Vitamin-C and Vitamin-D3. He gives us great information about dosing, when and how to take it, and how it should be in everyone's cabinet and part of a daily routine! Some Questions We Discuss: What is quercetin and what are the benefits of it? (5:14) Who might benefit from taking quercetin daily? (8:43) What makes quercetin different from other histamine blockers? (11:55) Can you take too much quercetin?(13:35) Are there any medications that quercetin negatively interacts with? (18:43) Some Key Takeaways From This Episode: Quercetin has surprising benefits for athletes due to its antioxidant effects. (6:16) People with allergies, seasonal or in general, can benefit greatly from quercetin. (8:55) We are overwhelmed with environmental stressors that hurt our lungs so we need to support them. (10:03) Everyone needs to be taking zinc supplements. (14:32) Increase Vitamin C levels when taking quercetin. (18:55) Quercetin may be better suited as a preventative as opposed to a response. (24:18)

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Felicia: Hello Dr. Cabral. What are your thoughts on this magnesium supplement ? Magnesium bisglycinate, fillers (microcrystalline cellulose, dicalcium phosphate), anti-caking agents (silicon dioxide, magnesium stearate), coating agents (hydroxypropyl methylcellulose, glycerol). Worth taken or should I look for another one? Thanks for your help                              Audrey: Hi Dr. Cabral, Thank you for being my go to person for all of my health questions! What are your thoughts on taking creatine while pregnant? I am going to keep strength training throughout my pregnancy and am hoping this helps with maintaining some muscle. I've read great things about it helping mom and baby but want to know what you think. I know you cannot give medical advice. Thanks                                                                                                                               Elsa: Hi Dr. Cabral! Thanks for all the information you provide. I'm a fairly recent listener but already have learned so much from you. May God continue to bless you, your family, and your team. My question is regarding my husband. He did a genetic test and came out positive for the MTHFR heterozygous A1298C and COMT heterozygous G472A (Val108/158Met). I've listened to your recent podcasts on COMT, but my question is regarding supplements to avoid if you have this variant. He doesn't take any medications, and already takes methylated B complex to support MTHFR and high homocysteine levels (8.3). He also takes Vit C, Zinc+Copper, Mag, Vit D+K2, Omega 3s, Probiotics. The test results indicate to avoid Quercetin and Green Tea because they are COMT inhibitors? True? Thanks.                                        Bettina: Hello Dr. Cabral. What are your thought on Super CitriMax for weightloss using a combination of 4500 mg Garcinia Cambogia with 60% HCA with 600 mg of Chromium and 1000 mg of B3 Niacinamide or B3 Nicotinamide? Thanks for your thoughts on this.                                                                                             Hannah: Hi Dr Cabral! I wrote in when you said the que was closer to 2-3 weeks and I haven't heard my question yet so this is incase my question got lost- myself and a couple of people I've met recently get an elevated heart rate when drinking alcohol (even 1 drink). This has never happened to me before and I'm very well hydrating prior, what else besides histamines could this be? Second, I have a very scant amount of blood per rectum every couple of days since starting the CBO, have you heard of this happening? I'm thinking to d/c citricidal early, I didn't test prior to CBO and only have 3 days left of that to see if it's related. Thanks for everything!!                           Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3389 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this episode, I break down the results of my Smart Nutrition methylation and nutrigenomics test — and how it's helped me finally understand the root cause of my inflammation, energy crashes, IBS symptoms, and persistent neck and eye issues. I share my exact results, including key gene variations like MTHFR, CBS, COMT, MAOA, and SOD2, and how these are impacting my: – Stress response and emotional regulation – Ability to clear toxins, sulphur, and ammonia – Digestion, sleep, and protein metabolism – Histamine sensitivity and inflammation Based on my profile, I'm now supplementing with: – Methylated B-complex (B12, B2, B6, 5-MTHF) – Buffered vitamin C – Choline (350mg with each main meal) – Glycine powder (with every protein meal) – Dicalcium Malate (to support mineral balance and inflammation control) – Omega-3 DHA/EPA – Magnesium glycinate (evening) – Marine collagen (evening) – Liposomal glutathione – Quercetin (for histamine and eye/neck inflammation) I'm also following a low FODMAP, ketogenic-style diet, spacing my protein evenly across the day, and using cold exposure and vagal tone exercises for nervous system support. You can order your own personalised DNA test and consultation here: https://smartnutrition.co.uk/methylation-test Book a consultation call: https://calendly.com/garygunn/consultation Work on your dating success for only £10.79/$13.50 per month with my Advanced Dating System and 100-Day Dating Challenge: https://social-attraction-courses.teachable.com/p/small-bundle Access all of my digital products for only £24.96/$33.20 per month: https://social-attraction-courses.teachable.com/p/gary-gunn-big-bundle View all of my digital courses here: https://social-attraction-courses.teachable.com/ My TikTok account: https://www.tiktok.com/@garygunnshow Follow me on Instagram: https://www.instagram.com/garygunnshow/ Access my podcast with over 200 episodes: https://soundcloud.com/garygunn Subscribe to my YouTube channel: https://www.youtube.com/c/GaryGunn?sub_confirmation=1 This video is for entertainment purposes only. Any action you take upon the information provided is strictly at your own risk, and we will not be responsible for any losses or damages in connection with the use of this video. The selection of techniques, opinions, programs, products, services, tools, templates, or manuals is not a guarantee of income or success. You are fully responsible for the effort you put in and the results you achieve by following the information in this video. All content, materials, and techniques delivered are proprietary and cannot be used, disclosed, or duplicated without permission. This video is for informational purposes only and does not form a professional relationship. Visit our website if you wish to hire us on a professional basis. #datingadviceformen #datingtipsformen #datingcoachformen

Think of aging as syndrome that can be overcome to live the best life possible.  Dr. Michael Aziz, author of The Ageless Revolution, takes this approach to promote longevity and overall well-being, based on the principles of functional medicine. In our conversation, he emphasizes the need for a holistic - whole body - approach to health, and advocates for practical lifestyle changes, including dietary adjustments and intermittent fasting, to promote longevity and overall well-being. The New York City-based physician is a sharp critics of US dietary guidelines, which he sees as outdated. He says they have contributed to the poor health of millions of people. He is also keen to distinguishes between superficial “anti-aging” and deeper, cellular-level “pro-aging” interventions.------This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. Visit our SHOP for more details and thanks for your support!  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

If there's one thing a lot of people are battling right now, it's seasonal allergies — and with the sniffles, the sneezes, and the brain fog, it's more than just annoying. In today's episode - we're revisiting my 7 top natural supports, plus a new method I've been incorporating this season. Whether you're dealing with itchy eyes, nonstop sneezing, or that can't-quite-think-straight kind of fog, this episode's for you.We're Covering:What's actually happening in your body when allergies strikeThe difference between allergy symptoms and a coldWhy staying hydrated helps control histamine (your allergy culprit)The surprising herbal tea with antihistamine benefitsThe plant pigment that can naturally reduce inflammationSpirulina: gross but effective (and how to make it bearable)Homeopathic optionsThe one thing to do before bed to reduce nighttime symptomsHow bursts of movement may actually help clear out congestionAnd the underrated power of kindness as medicineResources Mentioned:Sabadilla (homeopathic remedy for sneezing)RhinAllergy by Boiron (combination homeopathic formula)Stinging Nettle Tea (herbal support with antihistamine properties)Quercetin-rich foods: red onion, broccoli, raspberries, apples, parsleyVitamin C (bonus support during allergy season)Spirulina (immune-modulating blue-green algae)And if this episode helped clear your head — or just made you laugh through your congestion — feel free to send it to a friend, leave a kind review, or shout us out. It makes a real difference.Disclaimer: The information shared in this podcast is for informational purposes only and is not a substitute for medical advice. Please consult your healthcare provider for personalized support.

Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

Tis the season for itchy, watery eyes and runny, stuffy noses! But you don't have to suffer and there are lots of approaches for comprehensive relief from seasonal allergies. On this episode of Vitality Radio, Jared invites Ben Fuehrer from Utzy Naturals to discuss their Allurtica allergy formula, and how each of its key ingredients work to provide fast relief from allergy symptoms. They also discuss the importance liver health, and lifestyle habits that can help your body handle the season's allergens. Jared also chats with our Homeopathic Consultant, Amanda Kotter, about the synergy between homeopathic remedies that work great alongside Allurtica and on their own for seasonal allergy support!Products:Utzy AllurticaClearLife AllergyAllium CepaOmega-3Precision ProbioticLiverVitalityB5 Pantothenic AcidAdditional Information:#498: Cardiovascular and Metabolic Health Without Drugs with Ben Fuehrer#429: Homeopathic Formulas for Pain, Cold and Flu, and Seasonal Allergies with Marie CamilleTo schedule your Homeopathy Consultation with Amanda:Email Amanda@vitalitynutrition.comCall/Text 801-388-4133Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Doctor's Farmacy with Mark Hyman, MD Key Takeaways  Histamine intolerance and mast cell activation syndrome (MCAS) can be the hidden drivers behind a wide range of chronic conditions, such as fatigue, brain fog, food sensitivities, and skin issues – yet, histamine intolerance is often overlooked by conventional medicineMCAS is a condition where certain immune cells – called mast cells – release too many chemicals (like histamine) at the wrong timesUsing diet as a short-term therapeutic tool: A low-histamine diet or Low-FODMAP Dietis not a lifelong diet because tons of healthy foods have histamine in them Consume the freshest foods possible and avoid leftovers, as histamine levels in food rise over time after preparationFoods that are traditionally categorized as “healthy” may be contributing to your histamine issues; these include: aged meats, cheeses, fermented foods, and dairy Even though they are generally healthy, consuming them is like throwing gas on your histamine fire Implementing a low-histamine diet in three phases Phase 1 – remove alcohol, especially beer, wine, and champagne Phase 2 – remove canned and smoke fish (examples: anchovies), processed and fermented meats, aged cheese, pickled and fermented foods (sauerkraut, kimchi, yogurts, kefir, mustard, ketchups, vinegar, soy sauce)   Phase 3 – remove plant foods such as spinach, avocado, tomatoes, pineapples, citrus foods Treat IBS with a low-FODMAP diet, which is specifically designed to reduce the fermentable carbohydrates that gut bacteria feed on; this helps reduce: gas production, bloating, bacterial Foods to avoid: Garlic, onions, wheat, legumes, milk, soft cheeses, apples, honey, sorbitol, xylitol, stone fruits, artificial sweetenersFoods to consume: Carrots, spinach, bananas, chicken, rice, cheddar cheese, eggsSupplement to support healthy histamine levels:Quercetin – a natural plant compound that helps people with mast cell issues, histamine intolerance, and allergies (with additional benefits to metabolic function) Read the full notes @ podcastnotes.orgMany people struggle with mysterious symptoms like fatigue, brain fog, food sensitivities, and skin issues—only to be misdiagnosed or dismissed altogether. This conversation highlights how histamine intolerance and mast cell activation syndrome can be the hidden drivers behind a wide range of chronic conditions, and why they're often overlooked in conventional medicine. From the role of gut health, food triggers, and environmental toxins to deeper root causes like Lyme disease or mold exposure, it's clear that personalized, Functional Medicine is key to uncovering real answers. Understanding the immune system's role in histamine reactions—and how even “healthy” foods can be inflammatory for some—is a critical step toward healing. In this episode, I talk with Dr. Todd LePine, Dr. Elizabeth Boham, and Dr. Mark Pimentel about what histamine intolerance is, how it can be related to gut health, and why it's important to address it. Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine's focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders, and the neurobiology of mood and cognitive disorders. Dr. LePine enjoys skiing, kayaking, hiking, camping, and golfing in the beautiful Berkshires, and is a fitness enthusiast. Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women's Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine. Dr. Mark Pimentel is a Professor of Medicine and Gastroenterology through the Geffen School of Medicine and an Associate Professor of Medicine at Cedars-Sinai. Dr. Pimentel is also the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai, an enterprise of physicians and researchers dedicated to the study of the gut microbiome in order to develop effective diagnostic tools and therapies to improve patient care.  Dr. Pimentel has over 150 publications in many high-profile journals, and he is the author of the book, The Microbiome Connection: Your Guide to IBS, SIBO, and low fermentation eating. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Is Histamine Intolerance The Cause Of Your Mysterious Symptoms? What is Histamine Intolerance? Surprising Symptoms You Need to Know IBS: It's Not In Your Head—Advances In Diagnosing And Treating, Bloating And Tummy Troubles

In this episode we explore how the skills needed to live a longer healthier life can be honed through our own failures. Prof. Manu Kapur discusses the concept of 'productive failure' and how learning from our mistakes can lead to deeper understanding and personal growth. He shares his journey from aspiring soccer player to a researcher in learning sciences, discovering the importance of failure as a mechanism for learning.The conversation explores how these principles can be applied to health, fitness, and personal development, as well as the significance of setting realistic goals and learning from both personal and vicarious failures. Kapur also highlights the need for resilience in the face of unexpected setbacks and the importance of social connections in achieving long-term health and well-being.Kapur is a professor of Learning Sciences and Higher Education at ETH Zurich and the Director of the Singapore-ETH Center. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

In this video, Dr. G explores the alarming rise in allergies and offers natural solutions. Dr. G discusses the hygiene hypothesis – how overly clean environments weaken immune systems, leading to increased allergy and autoimmune disease risk. He highlights the dangers of conventional allergy medications and advocates for a holistic approach, emphasizing the importance of early childhood exposure to diverse environments and gut health. The video details five science-backed natural allergy remedies: quercetin, stinging nettle, butterbur, bromelain, and N-acetylcysteine, explaining their mechanisms of action and recommended dosages. #allergies #natural #wellness ==== Thank You To Our Sponsor! Jaspr Go to jaspr.co/DRG and use code DRG for $300 off for a limited time. ==== Timestamps: 00:00:00 - Allergies: Hygiene Hypothesis 05:07 - Immune System & Environment 06:23 - Air Quality & Home Health 09:26 - Quercetin & Nettle for Allergies 12:31 - Natural Allergy Remedies 15:40 - NAC, Allergies & Immunity Be sure to like and subscribe to #HealThySelf Hosted by Doctor Christian Gonzalez N.D. Follow Doctor G on Instagram @doctor.gonzalez https://www.instagram.com/doctor.gonzalez/

How can a joyful and holistic approach to food help us to live longer and better?  Elizabeth Borelli is a lifestyle coach, nutrition expert and author of Tastes Like La Dolce Vita, where she shares her mission to help us live not only longer but better—enjoying a long healthspan, a life where we stay healthy, active, and mentally sharp well into our later years. Her work weaves together a passion for nutritious, satisfying food and practical wellness strategies inspired by Italy's famously healthy lifestyle. In this fun interview, Elizabeth shares insights that go beyond recipes, offering a holistic approach to well-being and vitality, through lifestyle adjustments, mindset shifts, or some of her favorite Mediterranean-inspired habits. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

This week I discuss seasonal allergies and share the top eight natural remedies to manage them.I emphasize the importance of trial and error in finding what works best for individuals and provide practical tips for incorporating these remedies into daily routines.Here are the top 8 natural remedies I found through research:Nettle leaf tea can inhibit histamine production.Quercetin-rich foods can help stabilize mast cells.Nasal irrigation can significantly improve allergy symptoms.Probiotics are linked to better gut health and allergy relief.Butterbur may be as effective as antihistamines.Essential oils like eucalyptus can reduce congestion.Minimizing exposure to allergens is crucial.Spirulina has anti-inflammatory properties for allergies.Hopefully this helps combat the onset of seasonal allergies and allows you to enjoy being outdoors this spring!--If you love the Get Lean Eat Clean Podcast, we'd love for you to subscribe, rate, and give a review on Apple Podcasts and Spotify! Until next time!Links:Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680-----How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!| Listen to the Get Lean Eat Clean Podcast |►Apple Podcasts | https://podcasts.apple.com/us/podcast/get-lean-eat-clean/id1540391210►Spotify | https://open.spotify.com/show/0QmJzYZsdV6tUNbDxaPJjS| Connect with Brian |►Website | https://www.briangryn.com►Instagram | https://www.instagram.com/bdgryn►Facebook | https://www.facebook.com/getleanandeatclean►Twitter | https://twitter.com/grynnerwinner

Stem cell therapy is a growing field of medical intervention that is being used to enhance longevity and healthspan.  Advancements in research, biotechnology, and regenerative medicine have expanded its potential applications but it also raises both ethical and efficacy concerns. The primary ethical issue comes from the use of human embryos, which some people believe is morally problematic. While many countries regulate or restrict their use, others allow research with oversight. In this interview with Dr. Joy Kong, a stem cell specialist at Chara Health Center in Los Angeles, we explore the practical aspects of treatment as well as the wider considerations surrounding stem cell sources, the long-term effects of therapy, and Dr. Kong's personal journey in regenerative medicine. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

I dive into another exciting Q&A session where I break down my current supplement routine, the best natural alternatives to oregano oil for kids, and how to safely treat baby acne.  I share my personal experiences, science-backed research, and practical tips for postpartum recovery, gut health, and longevity. Send me a DM on Instagram to get your questions answered! I TALK ABOUT:  03:20 – The full list of supplements I'm currently taking and why 04:40 – Postpartum recovery (Needed Prenatal code: BIOHACKINGBRITTANY; Green Pasture Cod liver oil; BiOptimizers Magnesium code: BIOHACKINGBRITTANY) 11:40 – Gut health microbiome optimization (TinyHealth code: BIOHACKINGBRITTANY; Pendulum Akkermansia; Seed; Florastor; BiOptimizers P3-OM, BiOptimizers Masszymes code: BIOHACKINGBRITTANY) 24:05 – Longevity and anti-aging (Fatty 15 code: BIOHACKINGBRITTANY; NOVOS Core and Boost code: BIOHACKINGBRITTANY) 32:50 – Managing inflammation naturally (Partiqlar - L-Glutathione, Resveratrol, Quercetin code: BIOHACKINGBRITTANY) 35:40 – Oregano oil is too strong for kids and alternatives 38:55 – Natural immune boosters for kids: (Gaia Elderberry syrup; Herb Farm garlic oil; ARMRA colostrum; Mary Ruth's probiotics; Evivo code: BIOHACKINGBRITTANY) 41:20 – Natural remedies for baby acne (breast milk, probiotics, and toxin-free detergent -Branch Basics, Molly Suds, Attitude, Mother Dirt AO+) SPONSORS: Optimize your cardiovascular health with science-backed supplements from Calroy Health Sciences for better circulation, heart function, and energy—save $50 on bundles using my link. Elevate your brainpower and energy with four powerful mushrooms in a delicious daily drink from BiOptimizers Mushroom Breakthrough —get 10% off with code BIOHACKINGBRITTANY. RESOURCES: Optimize your preconception health by joining my Baby Steps Course today! Optimize your preconception health and fertility through my free hormone balancing, fertility boosting chocolate recipe! Download it now! My Amazon storefront LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Nutritionist Leyla Muedin discusses the potential benefits and considerations of using local raw honey as an immunotherapy for seasonal allergies and allergic rhinitis. Leyla explains how small amounts of local pollen in raw honey might help desensitize the immune system to allergens over time. She reviews various studies, highlighting both promising and inconclusive results, and cautions about the variability of pollen in honey and the risk of allergic reactions. Leyla also addresses the potential side effects of long-term antihistamine use, including an increased risk of dementia, and advocates for exploring natural alternatives. The episode is informative for individuals considering natural remedies and provides guidance on the safe use of honey for allergy relief.

Quercetin is having a moment, thanks to a viral discussion on Joe Rogan's podcast. But why? Is this now the new supplement that all self-respecting biohackers should be taking? Also today... the world's most expensive gym, has recently opened in Manhattan's West Village, targeting the super-rich who seek optimized health and fitness through biohacking. What they offer is pretty spectacular. But can we do the same on the cheap? Of course we can! (Sort of...) Follow Klaudia Balogh on Instagram. Join 30k+ weekly biohackers who receive the latest tech + techniques + reviews + insider biohacking news by signing up for the weekly newsletter here.   THIS SHOW IS BROUGHT TO YOU BY: Magnesium Breakthrough by BIOptimizers  Magnesium Breakthrough contains seven different forms of magnesium, each playing a unique role in your body. From improving sleep quality to enhancing brain function, and from boosting metabolism to balancing stress response, magnesium is involved in over 600 biochemical reactions. An epic supplement! Just go to bioptimizers.com/tony and use code TONY10 for 10% off. In the UK? Use the same discount code at https://bioptimizers.co.uk/.

Tune in to this episode of The Soaring Child Podcast, where Dana Kay, a board-certified holistic health and nutrition practitioner, explores the power of BioEssentials, a natural supplement designed to support children with ADHD. Combining the antioxidant and anti-inflammatory benefits of Resveratrol, Quercetin, and Pterostilbene, BioEssentials aims to enhance brain health, reduce inflammation, and improve focus. Listen now to discover the science behind these key ingredients, how they work together, and their potential to complement a healthy diet and lifestyle. Don't forget to grab your free supplement cheat sheet at the link below!  Links Mentioned in the Show:  My Favorite Place to buy Supplements - http://adhdthriveinstitute.com/supplements  Bio Essentials - https://shop.adhdthriveinstitute.com/bio-essentials.html  Bio Essentials Cheat Sheet - https://info.adhdthriveinstitute.com/supplement-for-bio-essentials    Links to Previous Episodes in this Supplements for ADHD Series: Magnesium -  https://adhdthriveinstitute.com/podcast/soaring-child-episode-93/  Saffron - https://adhdthriveinstitute.com/podcast/soaring-child-episode-136/  GABA - https://adhdthriveinstitute.com/podcast/soaring-child-episode-137/  L-Theanine -  https://adhdthriveinstitute.com/podcast/soaring-child-episode-142/  Key Takeaways: [3:27] Overview of Bio Essentials and Its Key Ingredients [5:15] How Bio Essentials Supports Brain Health and Cognitive Function [5:50] Pros of Bio Essentials for ADHD Management [9:26] Potential Drawbacks and Considerations [11:25] Natural Ways to Obtain the Ingredients in Bio Essentials Memorable Moments: "Our mission is to help families of children with ADHD thrive using natural strategies and practical solutions." "BioEssentials is a powerful combination of Resveratrol, Quercetin, and Pterostilbene designed to support focus, reduce inflammation, and protect brain health." "Inflammation in the body can mimic ADHD symptoms—even for people without ADHD." "You can't supplement your way out of a poor diet, but supplements like BioEssentials can be powerful tools in your toolbox." "This isn't about replacing medication, but finding complementary solutions that work with your child's unique needs." "Resveratrol, found in grapes, protects brain cells from oxidative stress and supports neurotransmitter balance." "Pterostilbene crosses the blood-brain barrier more effectively, enhancing its ability to promote cognitive function." "Small changes in diet or adding supplements like BioEssentials can make a big difference in reducing ADHD symptoms." "If we can reduce inflammation in the body, we can give our children a better chance to focus, regulate emotions, and thrive." "Always consult a healthcare provider before starting new supplements to ensure they align with your child's needs." Dana Kay Resources:

An episode from The Holistic Navigator. This is not to diagnosis or treat any disease or illness. Consult your physician before taking supplements or medications OR before you stop taking medications. This is for entertainment/informational purposes only-do your own research and talk to your doctor as needed! In light of a new variant and possible new waves of pandemic illness, we always want to be proactive and do what we can to provide information to help people combat illness naturally. We're thrilled to have Dr. Robert Rountree back on the show to walk us through his favorite supplements, backed by science of course, to help keep illness at bay. This episode is quite literally an A-Z look at what you need to give your body the best shot at staying well naturally. Meet Dr. Robert Rountree: On this week's episode we welcome back Dr. Robert Rountree to talk about his favorite supplements that EVERYONE should be taking to help combat illness. Dr. Rountree is a practicing physician out of Boulder, CO and is Chief Medical Officer for THORNE® and he breaks down the essential vitamins and nutrients he takes on a daily basis, gives suggestions for dosing, and even throws in a couple extra products that might not be on your radar. Some Points We Discuss: What nutrients should someone consider as they want to build their immune system? (5:53) What are some of the most important things to know about vitamin D supplementation? (21:03) What makes quercetin so unique for immune health? (40:24) Some Key Takeaways From This Episode: The alphabet list is not necessarily particular to any virus or illness. This is great for the immune system in general. (10:37) Always choose methylated B vitamins over folic acid. (16:59) There's a delayed effect with Vitamin D. You don't see the impact immediately. (26:44) Quercetin can stabilize immune cells and prevent the production of histamine. (41:25) This podcast is powered by ZenCast.fm

In this episode:Quercetin, a natural flavonoid, takes center stage in the Medical Mailbag as we dive into its potential benefits for preventing illness, especially during the cold and flu season. Jeff and Juliet explore the science behind quercetin's effectiveness, discussing various studies that highlight its role in supporting immune function for athletes and active individuals. The conversation shifts gears as I welcome Luke Tasker, a remarkable age group triathlete who has quickly risen through the ranks of the sport. Luke shares his unique journey from modern pentathlon to triathlon, detailing his training methods and the mindset that drives his success. With insights on goal-setting and overcoming challenges in competitive racing, this episode is packed with valuable takeaways for athletes of all levels.Segments:[06:12]- Medical Mailbag: Quercetin[32:15]- Interview: Luke Tasker Links@Taskertri on Instagram

Our guests in this episode have been described as the world's two oldest scientifically astute longevity activists. They are Kenneth Scott, aged 82, who is based in Florida, and Helga Sands, aged 86, who lives in London.David has met both of them several times at a number of longevity events, and they always impress him, not only with their vitality and good health, but also with the level of knowledge and intelligence they apply to the question of which treatments are the best, for them personally and for others, to help keep people young and vibrant.Selected follow-ups:Waiting For God - 1990s BBC ComedyAdelle Davis, NutritionistRoger J. Williams, BiochemistThe Importance of Maintaining a Low Omega-6/Omega-3 RatioLife Extension MagazineCalifornia Age Management InstituteFibrinogen and agingProfessor Angus Dalgleish, Nuffield HealthAbout Aubrey de Grey speaking at the Royal InstitutionGeorge Church, GeneticistJames Kirkland, Mayo ClinicDaniel Munoz-Espin, CambridgeNobel Prize for John Gurdon and Shinya YamanakaVSELs and S.O.N.G. laserXtend Optimal HealthFollistatin gene therapy, MinicircleExosomes vs Stem CellsPrevent and Reverse Heart Disease - book by Caldwell Esselstyn Jr Dasatinib and Quercetin (senolytics)We reverse atherosclerosis - Repair BiotechnologiesBioreactor-Grown Mitochondria - MitrixNobel Winner Shinya Yamanaka: Cell Therapy Is ‘Very Promising' For Cancer, Parkison's, MoreDeath of the world's oldest man, 25th Nov 2024Blueprint protocol - Bryan JohnsonMusic: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

Today, we're going to talk about kidney health. A big myth is that potassium is bad for the kidneys, but this isn't true! Our bodies require 4700 mg of potassium each day. The only time you'd want to avoid potassium is if you have advanced-stage kidney disease. Potassium protects kidney health in several ways. It helps lower high blood pressure, which damages the kidneys and protects against kidney stones. Too much sodium can be hard on the kidneys, but the remedy is more potassium. Many factors can contribute to kidney damage, including the following: •High sugar consumption •Alcohol •NSAIDs •Certain medications •Pesticides •Heavy metals •Food dyes •Phosphorus from soda A proper diet with adequate vitamin D, potassium, and magnesium can significantly improve kidney health. The following foods protect the kidneys from damage and support kidney health: 1. Vegetables: asparagus, celery, bell peppers, cabbage, cauliflower, garlic 2. Magnesium-rich foods: pumpkin seeds, leafy greens, avocadoes, magnesium glycinate 3. Probiotic-foods: kefir, yogurt, sauerkraut, kimchi 4. Moderate amounts of high-quality protein 5. High-antioxidant foods: strawberries, blueberries, blackberries, beets 6. Quercetin: onions 7. Extra virgin olive oil Consuming tea is a great way to stay hydrated and support kidney health. Polyphenols found in tea are very beneficial for the kidney. Green, nettle, dandelion, turmeric, and decaffeinated black tea are all great options. Frequent eating can overtax the kidneys' filtration system. A low-carb diet and intermittent fasting are very beneficial for kidney health. Intermittent fasting can decrease the stress on the kidneys and significantly reduce insulin. Too much insulin can be damaging to the kidneys. Recommended Olive Oil Link: https://sanmicheleorganic.com/product...

Dr. Ronald Hoffman and Nutritionist Leyla Muedin continue their reveal of the supplements they personally take.

In this special New Year's edition Q&A Dr. Ronald Hoffman and Nutritionist Leyla Muedin share their personal supplement regimens for 2025. They discuss the variety of supplements they take, including multivitamins, specific minerals, omega-3s, anti-inflammatories, probiotics, and immune-supportive nutrients. They also emphasize the importance of personalized nutrition and caution listeners against directly mirroring their supplement routines. The episode includes advice on seasonal adjustments to supplementation, the benefits of different nutrient combinations, and general tips for maintaining a balanced approach to supplement intake. Dr. Hoffman and Leyla also touch on their personal health goals and the rationale behind their choices, offering listeners insights into optimizing their own supplement strategies.

DATA: https://pmc.ncbi.nlm.nih.gov/articles... The Most Powerful Antioxidant (Melatonin) ▶️ • The MOST POWERFUL Antioxidant Is Mela... Did you know that too much iron can decrease longevity? Your body makes hydrogen peroxide that is used by the immune system to kill microbes. When hydrogen peroxide combines with iron, it can cause serious cellular damage. People with iron-deficiency anemia often have dysfunctional iron, which means it's unavailable to the red blood cells. This could be why we are not seeing a decrease in anemia even though we've increased iron in the food supply. Iron overload may increase your risk for Alzheimer's, Parkinson's, cancer, heart disease, and more. Excess iron causes oxidative stress and increases inflammation. As we age, we naturally accumulate more iron. Around 70% of our iron is stored in protein in the blood that helps carry oxygen. Ferritin should be inside your tissues to protect you from free iron and control when iron is released. This very efficient system recycles iron in the body. Certain pathogens, microbes, and infections use iron as fuel. This is why the body protects free iron. Some people feel better after donating blood, indicating they have too much iron. Too much iron without enough copper is a big problem. If you think you have this problem, limit iron exposure before taking a copper supplement. Iron is found in enriched flours, grains, and refined carbohydrate products. Shellfish, organ meats, sunflower seeds, and dark chocolate are good sources of copper. To combat oxidative damage caused by iron and other factors like alcohol, smoking, pollution, and junk foods, you'll want to build up your antioxidant reserve. Glutamine found in red meat is vital, but protein is the most important! It's especially important to consume enough protein as you get older. Zinc, manganese, magnesium, and selenium can increase antioxidant networks to help you regulate excess iron. Quercetin, curcumin, black tea, and increasing melatonin are also very beneficial. Lactoferrin is the most powerful chelator for iron. It's found naturally in dairy and can be taken as a supplement.

What if the best days of our lives were to come in our 70s or later? The societal norms around aging are far from optimistic, preferring to frame the process around dotage and frailty. But such views are increasingly being challenged, not least because the evidence suggests we can be active, purposeful and fulfilled, well beyond the traditional age of retirement.In her book, Turning: The Magic and Mystery of More Days, Becky Blue delves into the emotional, physical, and psychological aspects of aging, offering a roadmap to a vibrant and meaningful life at any age. She encourages people, particularly women, to take control of how they grow older with a new perspective rooted in empowerment. In this interview we explore Blue's unique approach to aging, longevity, and how we can all redefine what it means to grow older.Transcript and additional show note PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

What causes the “red wine headache”? Is it sulfites? A histamine reaction? Andrew Waterhouse, Professor Emeritus of Enology in the Department of Viticulture and Enology at UC Davis and Apramita Devi, Postdoctoral Scholar in the Department of Viticulture and Enology at UC Davis have identified a flavanol that can interfere with the metabolism of alcohol. That flavanol is quercetin, a natural product made in grape skins in response to sunlight. It is a natural sunscreen produced to protect the fruit from ultraviolet light. This conversation covers why quercetin may be more prevalent in high end wines, how skin contact during wine production impacts quercetin levels, and why sulfites may play a role in “red wine headache”. Resources:         74: The Spirit of Wine Andrew Waterhouse Andrew Waterhouse | Google Scholar Andrew Waterhouse | LinkedIn Apramita Devi | LinkedIn Apramita Devi |Google Scholar Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches Why Do Some People Get Headaches From Drinking Red Wine?  Vineyard Team Programs: Juan Nevarez Memorial Scholarship - Donate SIP Certified – Show your care for the people and planet   Sustainable Ag Expo – The premiere winegrowing event of the year Sustainable Winegrowing On-Demand (Western SARE) – Learn at your own pace Vineyard Team – Become a Member Get More Subscribe wherever you listen so you never miss an episode on the latest science and research with the Sustainable Winegrowing Podcast. Since 1994, Vineyard Team has been your resource for workshops and field demonstrations, research, and events dedicated to the stewardship of our natural resources. Learn more at www.vineyardteam.org.   Transcript [00:00:00] Beth Vukmanic: What causes. The red wine headache? Is it sulfites or a histamine reaction? [00:00:10] Welcome to sustainable wine growing with the vineyard team. Where we bring you the latest in science and research for the wine industry. I'm Beth Vukmanic executive director. I've been your team. Since 1994, we've brought you the latest science-based practices, experts growers and wine industry tools through both infield and online education. So that you can grow your business. Please raise a glass. With us as we cheers to 30 years. [00:00:37] In today's podcast, Craig Macmillan, critical resource. Manager at Niner wine estates with long time sip certified. Vineyard and the first ever sip certified winery. Speaks with two university of California Davis researchers. Andrew Waterhouse. Professor emeritus of enology and the department. of, viticulture and enology. And. Oprah meta Debbie. Post-doctoral scholar and the department of viticulture and enology. [00:01:04] They have identified a flavonol that can interfere. With the metabolism of alcohol. And that flavonol is called quercetin. A natural product made in the grape skins in response. To sunlight. It's a natural sunscreen produced to protect. The fruit from ultraviolet light. This conversation covers. Why quercetin may be more prevalent in high end wines. How. Skin contact during wine production impacts quercetin levels. And why sulfites may still play a role in that red wine headache. [00:01:36] Want to be more connected with the viticulture industry. But don't know where to start become a vineyard team member. Get access. to the latest science-based practices, experts, growers, and wine industry. The tools. Through both infield and online education so that you. You can grow your business. Visit vineyard team.org. And choose grower or business to join the community today. [00:01:57] Now let's listen. in. [00:02:01] Craig Macmillan: Our guests today are Andrew Waterhouse, Professor Emeritus in Enology in the Department of Viticulture Davis, and also Aparmita Devi. She is a postdoctoral scholar, also in the Department of Viticulture & Enology Davis. Thank you both for being here. [00:02:17] Andrew Waterhouse: Oh, we're glad to be here. [00:02:19] Craig Macmillan: Today we're going to talk about a really interesting topic. It's the role of quercetin , in wine headaches. The two of you recently co authored a paper on this one particular mechanism that might cause some people to get a headache after drinking even a small amount of red wine. But before we get into that, I want to ask you, how did you get interested in this topic? [00:02:37] Andrew Waterhouse: Well I've been talking to Steve Mathiasson. He's a Napa winemaker for actually quite a while, some years back. He suffers from headaches when he drinks certain wines. And we were chatting about possible mechanisms, and we even did a study many years ago with another postdoc in my lab to investigate a question we had or a theory we had, and that didn't pan out. But more recently we were chatting again, and I got interested in the topic again, and that's what got me interested, you know, just somebody knowledgeable who was suffering from headaches and. for listening. It was, it makes it more real and it's like, well, maybe we can figure something out. So that's what got us started. [00:03:17] Craig Macmillan: Apramita , how same for you. [00:03:19] Apramita Devi: Yeah. Same. Like I've been in touch with Andy and we have been talking about this project many years. So I was always interested because I come from biological science and metabolism and stuff I got interested after talking to Andy. [00:03:33] Craig Macmillan: Well, let's start with some basics. What is quercetin? [00:03:38] Andrew Waterhouse: Well, basically, it's a natural product made by grapes, but it's a very specific one. It's in the class of polyphenolic compounds, and it's in the class of flavonoids called flavonols. And what makes it interesting, I think, is that it is made By grapes, in the skin of the grape, and only in the skin of the grape, in response to sunlight. It's sometimes referred to as sunscreen for grapes. And it specifically absorbs UV light that would cause damage to, say, DNA and other macromolecules. So it's very clear that the grapes are producing this in order to protect themselves from ultraviolet light. [00:04:22] Craig Macmillan: Right. [00:04:22] Andrew Waterhouse: So the amount that's present in wine is highly dependent on the amount of sunlight the grapes experience. Not the vine, but the grapes themselves, And a friend of mine, Steve Price, was the first to note this. In a study way back in the 90s on Pinot Noir, he noted that there was more quercetin in sun exposed Pinot Noir grapes. And that observation has been confirmed many times now in different studies. where sun exposure is correlated with quercetin levels. [00:04:58] Craig Macmillan: and this is true just for red grapes as opposed to white grapes. [00:05:02] Andrew Waterhouse: Oh, no, no, there's more in white grapes. But when you make white wine, you throw away the skins. So there's no opportunity to get those materials into the wine. Now, an exception might be orange wine. But I don't know of any data on orange wine. [00:05:21] Craig Macmillan: Apramita , maybe you can talk about the metabolism part, the biology part. So when people consume alcohol, it's metabolized down certain pathways. Quercetin is also metabolized by the body into other forms? [00:05:33] Apramita Devi: Yeah, so the pathway for alcohol and quercetin are a bit different, but the location is liver, where it goes. So when people consume alcohol, it goes to the liver and then there are two enzymes which work on the alcohol. So the first enzyme is alcohol dehydrogenase, which convert it into alcohol into acetaldehyde. The acetaldehyde is the like the toxic metabolite in the body and it can have many side effects. That's why body has to get rid of it out of the liver system. So it has a second enzyme which is called the acetaldehyde dehydrogenase. So that convert acetaldehyde dehydrogenase into a non toxic component, which is acetate or acetic system. [00:06:24] So it comes out of the body. What happens when you consume quercetin along in the body, the quercetin also goes to the liver. Because quercetin adds too much quercetin as such is not good for the body and it has low bioavailability. So liver tag it in the form of quercetin glucuronide and then the body knows that it has to be flushed out of the system. So the interesting part is that when you consume alcohol and quercetin together, You are taking the both the metabolite acetaldehyde and quercetin gluconide in the same location inside the liver. And it gives the quercetin gluconide to interact with the acetaldehyde dehydrogenase enzyme. And that acetaldehyde dehydrogenase enzyme now cannot work efficiently. to convert the acetaldehyde into the acetate. So basically you are building up acetaldehyde in the body and it's not coming out of the system and you are seeing all those negative effects of the acetaldehyde in the form of flushing or headache or not. The other systems like what's like sweating. so we think that there is a correlation between these two pathways, which might be associated in red wine system. [00:07:47] Craig Macmillan: And how did you design your study? [00:07:51] Apramita Devi: The first when I talked to Andy, like he told me that he thinks that this system is because of inflammatory pathways and inflammation system. So he was kind of like, there is something in red wine, which is Triggering this kind of pathways or there is some system so, but we were not sure what exactly are those inflammatory system. [00:08:16] So we went back and saw some literature and we kind of find that there are some studies which told that quercitans inhibit the dehydrogenase enzymes and that what triggered us that okay alcohol is metabolized by these dehydrogenase enzymes. And wine also has these phenolics. So what kind of phenolics, other kinds of phenolics, or what types of phenolics can do this inhibition? [00:08:45] The method was basically in, was based on having different phenolics, which are present in red wines more compared to white wines, select them. And then just, we find this enzyme kits in the market to do this dehydrogenase. Inhibition tests like you put the test compound and it tells whether the enzyme is the inhibited or not. [00:09:09] So we just did that in a test tube system, like we added our phenolics with the enzyme, and we saw that which kind of phenolics are inhibiting this enzyme and screening them out. out of all. So while doing that, we screened different types of quercetin, like quercetin glucoside, quercetin galactosides, and other forms. [00:09:32] Then we also tested other phenolics. I can for all my rest in and other stuff. And we also choose quercetin gluconide because that is the metabolite which is circulating in the body. And then we kind of screen them based on the in the enzyme system and we see how much inhibition is happening there. [00:09:54] Andrew Waterhouse: Yeah. So what we did was a very basic test to experiment. We didn't test anything on people. [00:10:01] We basically tested to see which of these compounds could inhibit that enzyme because we knew that if that an enzyme could be inhibited the acetaldehyde would accumulate and you'd end up with people in that condition would end up with Flushing, headaches, as Aparmita said, all kinds of other symptoms. [00:10:20] Craig Macmillan: And this would vary by person. Different people may have a proclivity to produce more of certain enzymes than others. Is that true? [00:10:29] Andrew Waterhouse: We don't really have any information about that. That's going to take a lot of more work to test you know, the, the details here. For instance. Some people get red wine headaches and some don't, but we don't know whether, for instance, perhaps their enzymes are more inhibited by quercetin glucuronide, or maybe they're just more sensitive to acetaldehyde. [00:10:52] So that's going to take, you know, human studies where we measure a bunch of things. And try to figure out, try to sort through the, the details of how this impacts people individually. [00:11:04] Craig Macmillan: What would a study , with people, investigating this, what would the design be like? How would somebody go about doing that? [00:11:12] Andrew Waterhouse: Okay. So a human study. Could have a couple different possible designs. The one we'll probably use is we'll simply find two wines, two red wines, one that's low in quercetin and one that's high. And then those will be administered to people who get red wine headaches. We'll give it to them blind, they'll have to agree of course to participate in the study. [00:11:37] And then we'll see if their experience of headaches is related to the quantity of quercetin. Now, there's some other designs we could imagine using, which might be a little more straightforward, but we're not sure how relevant they would be or whether we could get approval to do this. So, for instance, one approach would be to find a red wine that's low in quercetin and then simply add it. [00:12:00] Now adding it is tricky for a number of technical reasons. Quercetin itself is very insoluble, so we would have to add what's called a glycoside of quercetin. So we'd have to get our hands on something that would dissolve, et cetera, et cetera. We're not sure we could get approval for that because we're adding a chemical to wine. [00:12:21] Now, the chemical would probably be classified as a supplement, and so it might be approvable, as it were. And then another very simple experiment, which we thought about a while ago, you can buy quercetin as a supplement in the market. It's readily available. [00:12:38] So, one possibility is to simply give our subjects a glass of vodka and give them pills that either contain quercetin or a placebo and see if there's a relationship between administration of quercetin and headaches. [00:12:54] Now the, the quercetin itself, as I mentioned, is very insoluble. So we may have to get these more bioavailable forms of quercetin for that experiment. [00:13:04] Craig Macmillan: That leads to a wine making question. So, if it's relatively insoluble is quercetin extracted from skins more in the alcohol phase at the end of fermentation? [00:13:11] Andrew Waterhouse: Yeah. It's, it's, it's extracted fairly quickly because it's in the skin, in the grapes, it's in the form of what are called glycosides. So these, Has the quercetin molecule with the sugar attached. That makes all those forms very soluble. [00:13:27] Craig Macmillan: Oh, okay. Okay. [00:13:29] Andrew Waterhouse: There's actually an occasional problem with certain red wines, most commonly Sangiovese, where after bottling the wine has had a large quantity of quercetin glucosides. And after bottling, they break down, the glycosides break down, releasing just a simple a glycone, quercetin, and you get this disgusting looking gooey brown precipitate in the bottle. [00:13:56] Craig Macmillan: ha [00:13:57] Andrew Waterhouse: Every few years I know the folks at ETS in Napa get somebody showing up with a bottle of Sangiovese that's got this. Disgusting sludge in it, and they can tell them without analyzing that. Yes, another case, of course, it's in precipitate in the bottom. [00:14:15] Craig Macmillan: Huh, that's interesting. I believe it was mentioned in the paper that , obviously different growing conditions are going to lead to different levels of quercetin and grapes based on how much sun exposure they have, etc. And that also different winemaking techniques would have an impact. [00:14:29] If consumers are looking for products if they know they have a headache issue Is it possible they could experiment with different product types? Products that were made with different production methods if they can find that out that might Impact their sensitivity or might impact how often it happens [00:14:46] Andrew Waterhouse: Yeah, it's a pity that. Consumers wouldn't have information on the level of quercetin. We would very much like to do a study along those lines, but we haven't been able to find any funding for that, just in case somebody wants to support that kind of work, we're happy to work with them. but anyway you know, it hasn't really been an issue for winemakers, so there isn't a lot of data out there. [00:15:08] There are a few studies that published amounts of quercetin, you know, in wines from different places, but the data is very, very limited and not really useful in providing consumers guidance. The one thing we can say is because, as I mentioned earlier, sun exposure is very important, in general if you look at a particular type of wine, a varietal, say Cabernet or Pinot Noir, that the grapes that are grown on very large vines, will have less sun exposure. [00:15:39] Essentially if you have a very highly productive vineyard making targeting an inexpensive line, you probably have much more shading of the fruit as a consequence of lower quercetin levels. Compared to a very high end vineyard, usually, the amount of sunlight is very tightly controlled, and one of the reasons for that is that there's very good data showing that wines that are high in quercetin have a better mouthfeel, better texture in the mouth. And it's not clear whether quercetin is directly responsible or whether it's a marker for something else that's produced under those conditions that leads to that. many years ago, we did a study looking at phenolics in Cabernet, and we observed that the very high end Cabernets that we tested were much higher in quercetin than the sort of average price type product. [00:16:35] And I think that that was true then. It's probably true now that, you know, a very good cabernet is, is made with very tight control of sun exposure. And there is a fair amount, of course, it can't be a complete sun exposure, or they probably get raisins by the end of the harvest, by the time you get to harvest, but there's a very deliberate management of sun exposure in high end wines. And it's for a reason to, get to higher quality product. [00:17:04] Craig Macmillan: Right, exactly! And, We know that the managed sun exposure, quercetin is a part of it but also it's connected to just total phenolics in general. Lots and lots of different compounds that are, you know, semi related. And I actually wanted to go back Aprametia you identified the quercetin glucuronide as being The highest in the ones that you tested, were there other things in that test and that assay that all were also stood out, maybe not as high as that, but really kind of stuck out as being different than the rest. [00:17:39] Apramita Devi: Actually, the quercetin gluconide was a standalone as a very high, like it's like 78%. The other things were around in that 30 percent range, so I'm not sure how significant was the impact of that, but there were quercetin glycosides forms, which were like around 30 percent inhibition of the enzyme, but [00:18:03] all others were very low. [00:18:04] Craig Macmillan: yeah, so it really stood out basically as it was head and shoulders above it. I would like to put this work into context a little bit. I, I work with the public quite a bit as part of my job and I have for years. And this topic comes up. All the time. This information definitely helps me my goal, when I talk to a consumer that has an issue with, wine headache or whatever it's not that I'm trying to sell them a product as much as it is. [00:18:29] They want to enjoy wine. They tell me this, they say, Oh, I love to have it. I just can't. Da da da. And then they'll say, it's like sulfites. And then I'll kind of explore that with them a little bit. Like, so can you eat dried fruit? Do you eat canned fruit? Do you have reactions to this or to that? Are you asthmatic? [00:18:48] Kind of sort that out and go, okay, I don't think maybe that's it. Maybe it's not. The other ones that I just learned about about 10 years ago was a biogenic amines, which made a lot of sense to me in terms of things like histamine reactions. What is your feeling about sulfites is contributing biogenic amines. [00:19:04] Maybe there's other things we haven't hit on, on this topic. What are your feelings about the, kind of the big picture of what potential for a diagnosing assist? [00:19:15] Andrew Waterhouse: Why don't you talk about amines [00:19:16] Craig Macmillan: Yes, please, [00:19:18] Apramita Devi: Biogenic amines like mostly the histamine and tyramine are the main ones people talk about whenever they come with this headache stuff. So I think because it's formed in the wine during the fermentation process, and there are these spec microbes which can convert the amino acids into this, biogenic amines the histamines are part of inflammatory reactions. People know that in biology and immunology. So it's very easy to be people connected that it might be a reason why people get headache. But what I always focus is like, there are far more other food products, for example, fermented meat products, which has far more higher amount of these biogenic amines. do people get headache if they have something similar with alcohol eating together with alcohol or something like that? But there is no mechanism told till now, they just tell that, oh, since it's histamine and it's related to this inflammatory reactions, it might be the cause. But there is no solid proof that it is the cause. [00:20:27] so I don't know whether it's there or it might be a pathway or not. [00:20:33] Craig Macmillan: One of the things that I find fascinating is how we evolve our, Hypotheses about things over time, and somebody has an hypothesis and they test it out, maybe they find something, maybe they don't, but then that kicks off this whole set of what I call naive science making up stories about why. [00:20:53] It's kind of a just so story. It's like, well, obviously then somebody comes along and checks it and says, Hey, wait a second. And we're no, or if this was true, then that would have to be true. And that's not true. You know, and that kind of thing and how we keep coming around to new ideas, which is what you folks have done, which I think is really, really cool. [00:21:10] Andrew Waterhouse: I was going to answer your question about sulfites. It's a really big question actually. Partly because sulfites have so much visibility and there's so much concern about it. I think sulfites themselves Have been studied pretty carefully there's one study where if they gave subjects a very high level of sulfites in wine, it was like very small, but statistically significant increase in headaches. [00:21:39] Or some adverse reaction, but other studies have shown no correlation. By the way, sulfites are antioxidants in case you hadn't heard that. So it seems very unlikely that sulfites by themselves are some sort of bad actor in this regard. Like you, I get these questions all the time. And what I heard so many times was. Oh, it's cheap wine. It gives me a headache. [00:22:06] Craig Macmillan: Yes. [00:22:07] Andrew Waterhouse: And have you heard [00:22:08] Craig Macmillan: I've heard that many times. And then on the opposite side of things, I've heard stuff like, Oh, I get headaches from American wine, but I don't get it from French wine. Or I always get headaches from European wines, but I never from California wine. So I'm trying to figure out, is there something going on? [00:22:26] Like, can you be allergic to burgundy? You know what I'm saying? Cause I mean, it could be, it could be something about burgundy. It's just stuff going on. And then the opposite. I had a guy who says, no, I don't have any that. But he says I was traveling in France, and we were drinking wine like it was water, and I never had a hangover symptom, and I did it, and I was like, I don't know dude, like I [00:22:45] Andrew Waterhouse: Yeah. Well, there's, there's one answer to some of this, which is if you're on vacation and you don't have to get up early and you're relaxed and you probably don't get as many headaches. [00:22:58] Craig Macmillan: Right. [00:22:59] Andrew Waterhouse: So I think that's a large part of it, especially for Americans visiting Europe. They're on vacation. but I think there is something to the sulfites question. And that is that inexpensive wine often, not always, but often has more bound sulfites. [00:23:18] Craig Macmillan: Yep. [00:23:19] Andrew Waterhouse: And this is probably because those grapes have a little bit more mold on them or a lot more mold. And when they get to the crusher, the winemaker goes, Oh, there's mold on these fruits. So we're going to add sulfites to, to take care of the botrytis, right? [00:23:34] We don't want the fruit to get oxidized and damaged. They had a bunch of sulfites. The consequence of that is that in the finished line, There's a lot more. Bound to SO2, which shows up in the total SO2 number. [00:23:47] You know what it's bound to? [00:23:49] Craig Macmillan: No. [00:23:49] Andrew Waterhouse: It's bound to largely acid aldehyde. [00:23:52] Craig Macmillan: Really? [00:23:53] Oh! Well that would make sense. Yeah, that would make sense. [00:23:56] Andrew Waterhouse: And the, the reason for that is that during the fermentation, the yeast are converting all this sugar the alcohol, but there's an intermediate step which is acetaldehyde. [00:24:06] Craig Macmillan: Right. [00:24:07] Andrew Waterhouse: If you have SO2 floating around, as you would if you'd added a lot of it up front, it binds that acetaldehyde before it gets reduced to ethanol, to alcohol. if you start a fermentation with a high level of added SO2, then you will end up with a wine that has more bound acetaldehyde. And that could be a marker, say, of less expensive wine. [00:24:31] So it's possible that those people are, what they're experiencing is direct ingestion of acetaldehyde, which is being released into the blood and that that's causing them a problem. [00:24:45] Now, I've looked and looked, and I cannot find any data on what's called absorption of acetaldehyde from wine, or from food for that matter. I keep, I'm going to keep looking, [00:24:56] but for some reason or other, this hasn't been subject of a published study, although maybe I just haven't been competent enough to find it. [00:25:05] Craig Macmillan: I doubt that. [00:25:07] Andrew Waterhouse: Well, sometimes these are, you know, they're very specialized and they're indexed in funny ways. And, [00:25:13] You know, and the other thing was, you know, when the study came out, I had all these questions. I was talking to this one reporter and she said, well, I can drink natural wine. [00:25:24] It doesn't give me headaches. And I was like, oh boy, what's this about? [00:25:27] Craig Macmillan: Yeah. [00:25:28] Andrew Waterhouse: But thinking about that further when you make natural wine, you don't add any sulfites or at least you're not supposed to, Right. And consequently in the finished wine, the level of acetaldehyde would have to be very low or else it would smell like sherry. [00:25:41] Craig Macmillan: Right. Right. [00:25:43] Andrew Waterhouse: And yes, granted, many natural wines have funky smells, but they don't by and large smell like sherry. [00:25:49] So it's possible that natural wines have in general, Much less acid aldehyde than conventional one. you know, all these questions have brought up some interesting issues, I think, you know, the industry should be looking into you know, these are these issues like how much acid aldehyde Do we want in our wine and how can we reduce it if we want to reduce it? [00:26:15] I don't think anybody's really looking at that yet. I think that would be a very interesting question to pursue. Oh [00:26:24] Craig Macmillan: you just, you just reminded me of, of something two things that I, I had forgotten about. One I used to teach like enology for babies, enology for dummies thing for the public. I am in no way qualified other than just experience to do that. [00:26:39] But I broke it down in that I do that sugar aldehyde, alcohol arrows, and I'd say, okay, this, this acid aldehyde. Remember this one? This one's coming back. We're going to see this again later. So write this one down. We're going to get to that later. And sure enough, now it's just through the body and, and I think breathalyzers work based on that. [00:27:00] Don't they? It's like density. Something like that. So the aldehyde, they're actually, [00:27:05] I think so. I got to look that up again, but because by the time it gets to your breath, your body's, Processing it, right? Hugely important. Not just that compound, but aldehyde is just kind of a general well, maybe we should all invest in like some kind of, I don't know, AO unit or wine X ray or something at our house. [00:27:21] And then we could get the totals and know before we drink it you know, maybe we could figure out if somebody could come up with a consumer friendly, you know, put it in a vial and shake it and it turns blue. Don't drink it kind of thing. I'm just being silly. I don't know. [00:27:34] Andrew Waterhouse: idea. [00:27:35] Craig Macmillan: You go to different like wine shops and stuff, and there's all kinds of stirs and additives and strainers and funnels and stuff that are supposed to take things out. [00:27:45] And I've always really wanted to see what those things do. They do anything or not, or I don't know. I'd like to try it. Finally, is there one takeaway on this topic, this question to both you, one takeaway you'd like people to know, I [00:27:57] Andrew Waterhouse: well, I think the key thing is that we haven't done any experiments on people yet. [00:28:03] Craig Macmillan: Right. [00:28:04] Andrew Waterhouse: And so what we have here is, I would call it a well founded theory, [00:28:09] Craig Macmillan: Mhmm. [00:28:09] Andrew Waterhouse: I think people shouldn't rush out and start changing the way they drink yet. They might want to try some experiments. But we don't have the final word yet. [00:28:20] Craig Macmillan: Right, right. [00:28:24] Apramita Devi: Same. Yeah. This is just very preliminary study. And we just have a theory out. So we still don't know, like, what happens in the actual body. [00:28:34] Craig Macmillan: Well, I hope that we can do that. [00:28:36] Andrew Waterhouse: We're always looking for support for experiments. If anybody wants to support that, get in touch. [00:28:43] Craig Macmillan: You know, another creative thought that I have when I'm preparing for this is like, you know, , people either get headaches from wine or they don't. If I'm someone who wants to enjoy wine, but gets headaches, I would be really attracted to a product that had a back label if we could make health. statements, which we cannot, that would say now low in quercetin or, you know, headache free, you know, no, we would never get that through TTP, obviously, but but, but, you know, but we went round and round with that on sulfites, you know you know, organic waste, no added sulfites, you know, you can say that. [00:29:14] Andrew Waterhouse: I think it would be possible to perhaps have a declaration on a bottle about the level of quercetin, whether it's high or low. I suppose. I don't know. [00:29:24] One company did get a label through that had resveratrol levels on it, but then TTB stopped approving that. So only one company has that approval. But I think in that case the reason for denying the label is that it is a proxy for health claim. Thank you. [00:29:44] Quercetin, you know, whether it's high or low is really, it's not, it's not making a health claim. We're not claiming that this wine is healthier for you than the other has to do with headaches or not headaches. [00:29:55] And I don't see that as really a health claim. [00:29:58] Craig Macmillan: Well, let's just see how this develops. You never know. Let's face it. I mean, we're talking about nutrition. This is August of 2024, the date for this recording. We're talking about having nutritional labeling on wine. Right? Which I think would be a very interesting nutritional label, quite frankly. [00:30:13] I would, I would love to see that, you know. Zero percent of the RDA of everything, again, at the end of one of my lectures I'd introduce potassium, and at the end I'd say, so how much wine do you have to drink to get your RDA of potassium? You have to drink a gallon and a half of wine a day. So, maybe not a big contributor. Maybe not a big contributor. Where can people find out more about both of you? [00:30:37] Andrew Waterhouse: Well, I think probably the best starting point would be our LinkedIn pages. [00:30:43] Craig Macmillan: And those will be in the show notes. [00:30:45] Andrew Waterhouse: and I do have a website at UC Davis called waterhouse. ucdavis. edu. [00:30:52] Craig Macmillan: And that will be in there as well. What about you, Apremita? [00:30:54] Apramita Devi: For me, LinkedIn page. [00:30:58] And if people want to see about my research or my past research, they can go to my Google Scholar page to [00:31:05] Craig Macmillan: Awesome. Thank you. Well, thanks so much for being here. Our guests today were Andrew Waterhouse, Professor Emeritus in the Department of Viticulture and Enology at UC Davis, and Apramita Devi, a postdoctoral researcher in viticulture and knowledge at UC Davis. Really interesting work. [00:31:21] I'm glad that you folks are doing it. I've been a big fan of you, Dr. Waterhouse, for a long time, and now that I've seen your work, I'm a big fan of you. Apremita. You've done some pretty cool stuff in the last five years. So again, thanks. And thank you for listening to Sustainable Wine Growing with Vineyard team. [00:31:38] Please keep downloading episodes. Please visit the show page. Lots of information there. And we also have a new publication, Understanding Wine Chemistry by Andrew Waterhouse, Gavin Sachs, and David Jeffrey. Is that correct? [00:31:53] Andrew Waterhouse: That's correct. [00:31:55] Craig Macmillan: This is out in the world now. [00:31:57] Andrew Waterhouse: It's just out this month. [00:31:59] Craig Macmillan: That sounds like a must have. [00:32:01] Andrew Waterhouse: I agree. [00:32:03] Craig Macmillan: That sounds like a must have. , I will leave the name out, but there was a very famous book written by a group of folks from CSU Fresno and some collaborators. And I don't have a copy because I bought five copies in my cellar. People stole them every single time. So, this is the same kind of book, folks. [00:32:20] Maybe buy five copies. And just hand them out to give one to your assistant winemaker. Give one to your cellar master and just say, here, these are yours. I'm keeping my copy. Thank you very much. That's, that's really cool. And again, thanks for being on the podcast. [00:32:33] Beth Vukmanic: Thank you for listening today's podcast was brought to you by wonderful laboratories. Wonderful laboratories operates two state of the art high throughput laboratories. He's located in Shaffer, California to support pathogen detection and nutrient analysis. The team provides full service support to customers with field sampling. Custom panels and special projects. They're. Customers include pest control advisors, growers, consultants, seed. Companies, backyard gardeners, ranchers, and more. [00:33:10] Make sure you check out the show notes. To learn more about. Andrew. And Oprah meta. To read a great article about their research. Why do some people get headaches from drinking red wine? [00:33:19] And if you're looking. Looking for. Some more fun wine at trivia to share at holiday parties this season. Listen into sustainable Winegrowing podcast episode. 74, the spirit of wine. [00:33:31] If you liked the show, do. It's a big favor by sharing it with a friend subscribing and leaving us a review. You can find all of the podcasts@vineyardteam.org slash podcast. Podcast. And you can reach us at podcast@vineyardteam.org until next time, this is sustainable. Winegrowing with the vineyard team. [00:33:49]   Nearly perfect transcription by Descript

Accurate body composition data is often seen as the holy grail of information for the longevity-minded biohacker.  Calipers are an accurate way to measure body fat. Smart scales and medical facilities equipped with DEXA machines also do a good job.  But now it is possible to generate body composition data using the camera on your phone.  In this episode, Jason Moore, CEO and founder of Spren, discusses the intersection of technology and health and the significance of understanding body metrics like muscle mass and fat distribution. We also explore the role of AI in health monitoring and the future of personalized health data. Transcript and additional show notes Flexbeam Red Light therapyA wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Code LLAMA. Discounts vary - see details of the current offer here PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Today, I'm going to tell you about some important foods and nutrients that should be part of a healthy diet for people over 50. Dr. David Sinclair, an expert on longevity, has researched longevity genes called sirtuins. NAD can increase sirtuins! NAD is derived from niacin. It works inside your mitochondria, converting food to energy. As we age, our NAD decreases. Many people take supplements and get injections to boost NAD. Dr. Abram Hoffer wrote a book about the diseases caused by too little niacin and how many diseases can be cured with mega doses. He's one of the doctors who started the Orthomolecular Medicine Group, which used high doses of nutrients to create therapeutic dosages. The following foods can increase NAD and should be part of a healthy diet for people over 50: 1. Beef liver 2. Grass-fed red meat 3. Probiotic-rich foods—raw sauerkraut, yogurt 4. Parsley (celery or chamomile tea can also work) 5. Curcumin—turmeric 6. Quercetin—onions 7. Omega-3 fatty acids—wild-caught fatty fish, cod liver Sulforaphane, found in cruciferous vegetables, is also beneficial for healthy aging. Broccoli sprouts and radish sprouts are great to add to salads! Anthocyanins, found in blue and purple foods like blueberries, blackberries, and purple cabbage, are also good for anti-aging. Niacin: The Real Story BOOK LINK: https://www.amazon.com/Niacin-Story-W... A Plague of Corn BOOK LINK: https://www.amazon.com/Plague-Corn-So...

As we get older, how can we still enjoy a runners high or exercise-induced euphoria, while being careful not to get injured? Dr. Kevin R. Stone is an orthopedic surgeon, the founder of the Stone Clinic in San Francisco, and author of Play Forever: How to Recover from Injury and Thrive. With a passion for helping patients play until they drop, Dr. Stone is redefining what it means to maintain a high-quality, active lifestyle across the decades. In this conversation he challenges the conventional idea that aging necessitates a retreat from high-impact sports, emphasizing instead how new therapies can extend athletic longevity, including his clinic's latest findings on delaying or avoiding knee replacements. He also advocates for a new exercise mindset, replacing workouts with playouts and a need to "find that giggle in life."Transcript and additional show notesDISCOUNTS PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

There are many ways that vitamin D function supports cancer prevention. Vitamin D triggers a cell to commit suicide if it's damaged. It helps regulate cell growth and has potent anti-inflammatory properties. Vitamin D enhances almost every part of your immune system, enhances chemotherapy, and makes insulin more sensitive. It downgrades genes that cause cancer and supports the gut microbiome, which is 80% of your immune system. In a cancer cell, inflammation and a hypoxic, acidic environment block the absorption of vitamin D. Cancer also blocks the enzymes that allow you to convert inactive vitamin D to the active form. Cancer damages the liver and kidney, two significant sites of vitamin D metabolism. Around 80% of tumors produce a hormone similar to the parathyroid hormone, which extracts calcium from our bones. This is why hypercalcemia is a side effect of cancer. When the parathyroid hormone goes up, it lowers and inhibits vitamin D. Too much calcium in the blood also inhibits vitamin D. There are two systems of vitamin D: one that affects bone and calcium, and the other that supports the immune system. The bone system only requires a small amount of vitamin D every two weeks, while the other requires higher amounts daily. When dealing with cancer, consider taking around 50,000 IU of vitamin D with magnesium, vitamin K2, and zinc daily. The World Health Organization acknowledges that vitamin D has anticarcinogenic properties. Autoimmune conditions, osteoarthritis, tuberculosis, and HIV are also associated with vitamin D deficiency. Along with increasing vitamin D3, the following epigenetic factors can help with cancer prevention: 1. Magnesium 2. Omega-3 fatty acids 3. Resveratrol 4. Quercetin 5. Curcumin 6. Berberine 7. Intense exercise 8. Sulforaphane 9. Ginger 10. Fasting 11. Low-carb diet 12. Probiotics 13. Infrared light 14. Decreasing stress DATA: https://orthomolecular.activehosted.c... https://www.mdpi.com/2076-3417/10/12/...

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