Podcasts about thymine

Follow Shane and Duncan along the twists and turns of the double helix as they unravel the history of genetics and DNA profiling. From Watson and Crick to the Human Genome Project, from Green River to the Golden State Killer, learn how genetic material holds the key to solving seemingly unsolvable crimes and curing formerly incurable diseases.  ~ In this episode:   Deoxyribonucleic Acid: The "Blueprint for Life" The Structure of DNA Nucleotides: Adenine, Cytosine, Thymine, Guanine Sugar Phosphates Friedrick Miescher Photo 51 Rosalind Franklin Watson and Crick The Eagle Pub Nature Magazine DNA Sequencing Frederick Sanger The Human Genome Project DNA Profiling Jeffrey Glassberg Alec Jeffries Murderer Colin Pitchfork: The First Success Restriction Fragment Length Polymorphism The Green River Killer: Gary Ridgeway The Golden State Killer: James D'Angelo Junior CODIS: The Combined Data Index System Touch-DNA The Pitfalls of Partial DNA Successes ~ Support the show by becoming a Midnight Minion, Menace, or Maniac, and unlock exclusive bonus content over at PATREON ~ Chat with fellow insomniacs and vote on episode topics via DISCORD ~ Join the Midnight Masses! Become an Insomniac by dropping a review, adding us on social media, and contacting us with episode ideas.  And we now have Midnight Merch! Show your Insomniac pride and pick up a tee shirt or coffee mug to spread the word!  Midnight Merch  ~ Leave an Audio Message! ~  Instagram ~ Podcast Website ~ Episode Transcript          

Artist, Twitch personality and slime aficionado Thymine joins the reunited RPG Pals to discuss Dragon Quest XII, Dragon Quest III HD-2D, and everything announced during last week's Dragon Quest 35th Anniversary livestream. Fanbyte Podcast Network (We do other podcasts too!) Follow us on Twitter (Yell at us on Twitter in good ways.) Talk to us on Discord (Talk to us and our loving community. Also we have a pets channel that is very good.) Twitch Live Streams (Hang out with us live.) Rate and review our show (Please show us your support by rating and telling Paul how much you love his work to make his heart feel good.) Learn more about your ad choices. Visit megaphone.fm/adchoices

If there is one rule in biology, it is that there is an exception to every rule. This includes even the basic biochemistry of DNA, which was once thought to be universal. On this episode, host Lauren Richardson and Judy Savitskaya (a16z bio deal team member and synthetic biology expert), discuss the results and implications three related articles co-published in Science, which all advance our understanding of a very unique kind of DNA. If you open any biology text book, it will say that the genetic code is made up of 4 bases: Adenine, Thymine, Cytosine, and Guanine, or ATCG. But, back in 1977, scientists discovered a phage — the technical term a virus that infects bacteria — that encodes its genome in ZTCG. Z is a derivative of A that has an extra amino group tagged on, and while that may sound minor, it changes some of the key properties of DNA. These three new articles seek to understand how Z is made and how it is incorporated into DNA. This is essential information for taking Z from a weird, wild bio story into a practical application. The conversation covers what makes Z different than other bases, what these three articles reveal about the synthesis and polymerization of Z, and how we can use use Z in a wide range of applications, from bio-containment to new therapeutics to DNA storage.The three articles discussed are:"A widespread pathway for substitution of adenine by diaminopurine in phage genomes" by  Yan Zhou, Xuexia Xu, Yifeng Wei, Yu Cheng, Yu Guo, Ivan Khudyakov, Fuli Liu, Ping He, Zhangyue Song, Zhi Li, Yan Gao, Ee Lui Ang, Huimin Zhao, Yan Zhang, and Suwen Zhao"A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes" by Dona Sleiman, Pierre Simon Garcia, Marion Lagune, Jerome Loc’h, Ahmed Haouz, Najwa Taib, Pascal Röthlisberger, Simonetta Gribaldo, Philippe Marlière, and Pierre Alexandre Kaminski"Noncanonical DNA polymerization by aminoadenine-based siphoviruses" by  Valerie Pezo, Faten Jaziri, Pierre-Yves Bourguignon, Dominique Louis, Deborah Jacobs-Sera, Jef Rozenski, Sylvie Pochet, Piet Herdewijn, Graham F. Hatfull, Pierre-Alexandre Kaminski, and Philippe Marliere 

Susanne Somerville is the CEO of Chronicled, founded in 2014 with the hopes of building the ultimate enterprise blockchain platform. And more recently in 2017 she founded the Mediledger Network, one of the largest and most active healthcare/blockchain consortiums. Current working group members and partners include Genentech, Gilead, Bayer, Pfizer, PWC, SAP, Deloitte, IQVIA, GS1, Walmart and more. Susanne is trailblazing a path for pharma companies to use blockchain tech in a way that will improve their supply chain operations and revenue management processes. https://www.chronicled.com/ https://www.mediledger.com/ Show Notes •Introduction of Susanne's background •Journey from ChemE to Pharma supply chain to blockchain •Origins of Chronicled and Mediledger - value proposition, problem statement •How is COVID19 impacting healthcare supply chains? •Most challenging Supply Chain problems fit for DLT - data entry, track and tracing, temperature monitoring, fraud, counterfeits •What responsibilities does Chronicled have as the custodian of the MediLedger network? •Industry Standards – GS1 and HIBCC (Health Industry Business Communications Council) database •Customer mapping process and how different trading partners can align interests •Does Mediledger need blockchain? Why? •“It’s like putting your own private embassy behind your trading partners firewall” on the benefits of blockchain for multi-party data exchange •Chronicled Products - Product Verification / Contracts and Chargebacks •Network stakeholders - Healthcare providers, GPOs (Group purchasing organization), Manufacturers, distributors •Technical specifications (architecture) of Chronicled network •Permisssioned Blockchain protocol – Substrate/Parity Tech Stack •Data storage •Node participation and governance •Libp2p messaging •Smart contracts •FDA DSCSA pilot experience and learnings from regulators •Managing between data transparency and privacy •Chronicled team and culture around privacy and security •Industry Partners and concept traction - existing partners and pilot projects •Can you describe the competitive landscape and any direct competitors to your business? •Platform/Ecosystem roadmap 2020 and beyond •Favorite book – Midnight’s Children by Salman Rushdie •What do you believe in that most people would disagree with? •Who's your favorite US president of all time? •How are you handling with the physical distancing measures? •Final takeaways News Corner The COVID19 pandemic has highlighted how Genetic data may reveal susceptibility to certain diseases. On June 8, 23andme announced it has been conducted research studies to determine if blood type is associated with lower risk of infections or symptoms. In a person’s DNA, a Thymine base on their ABO gene determines if that person has blood type O. Early results suggest Individuals with O blood type are between 9-18% percent less likely than individuals with other blood types to have tested positive for COVID-19. This research study is continuing to grow and people are beginning to reconsider the role of genetic data in our digital world. https://blog.23andme.com/23andme-research/23andme-finds-evidence-that-blood-type-plays-a-role-in-covid-19/ Remember, the Health Unchained podcast is for informational and entertainment purposes only and we are not providing any sort of legal, financial, or medical advice. Please do your own research and due diligence before making any important decisions related to these matters. Special thanks to Bert Miller and Christiane Wirrig who both have newsletters covering the industry. https://bert.substack.com/ https://bluesteens.substack.com/ Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind

Interview with Dr. Howard Kornfeld, member of the Frontline COVID-19 Critical Care Working Group. They are promoting the MATH+ protocol to treat COVID-19 patients at the early stages of hypoxemia, based on the conventional drugs methylprednisolone, ascorbic acid, thiamine, heparin, zinc and vitamin D. Testing is being done by experienced emergency doctors familiar with similar protocols using steroids, ascorbic acid and heparin for other ARDS (Acute Respiratory Distress Syndrome) diseases of the lungs. See Covid19CriticalCare.com Email topics: Suggested doses for Vitamin C and Zinc as preventative measures; The challenge of finding existing antiviral drugs that might work against Coronavirus

Interview with Dr. Howard Kornfeld, member of the Frontline COVID-19 Critical Care Working Group. They are promoting the MATH+ protocol to treat COVID-19 patients at the early stages of hypoxemia, based on the conventional drugs methylprednisolone, ascorbic acid, thiamine, heparin, zinc and vitamin D. Testing is being done by experienced emergency doctors familiar with similar protocols using steroids, ascorbic acid and heparin for other ARDS (Acute Respiratory Distress Syndrome) diseases of the lungs. See Covid19CriticalCare.com. Email topics: Suggested doses for Vitamin C and Zinc as preventative measures; The challenge of finding existing antiviral drugs that might work against Coronavirus

UV excitation of the DNA single strand (dT)(18) leads to electronically excited states that are potential gateways to DNA photolesions. Using time-resolved infrared spectroscopy we characterized a species with a lifetime of similar to 100 ps and identified it as a charge separated excited state between two thymine bases.

Dr Norman Cohen introduces four key characteristics any set of inherited instructions needs to have.

Transcript -- Dr Norman Cohen introduces four key characteristics any set of inherited instructions needs to have.

Dr Norman Cohen introduces four key characteristics any set of inherited instructions needs to have.

Transcript -- Dr Norman Cohen introduces four key characteristics any set of inherited instructions needs to have.

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Wed, 1 Jan 1964 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3438/ http://epub.ub.uni-muenchen.de/3438/1/066.pdf David, Charles N. David, Charles N. (1964): UV inactivation and thymine dimerization in bacteriophageΦX. In: Molecular and General Genetics MGG, Vol. 95, Nr. 4: pp. 318-325. Biologie