Podcasts about inherited

349: Conceiving naturally is a hot topic in this day and age, and IVF has skyrocketed as the go-to method of conceiving for couples. But is that the best option? And should we be looking at other variables before spending our time and money on IVF? Natalie Crawford is here with me today to talk all things infertility, biomarkers, “healthy habits” we may be doing that are actually hindering a woman's chances to conceive, and so much more. Natalie is a double board certified fertility doctor and has helped thousands of patients and followers learn about their bodies and their fertility, empowering them with education and learning to advocate for themselves in their own fertility journeys. Today's discussion is an eye opener for anyone trying to conceive naturally or via IVF. Topics Discussed: → Getting pregnant when you don't have a period→ Infertility causes and how to fix them→ Hormonal birth control's effects on fertility→ How our mothers' habits while pregnant affect our fertility→ AMH, what is it and why should we get tested→ “Healthy habits” sabotaging our fertility (including men) As always, if you have any questions for the show please email us at digestthispod@gmail.com. And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By:  → Manukora | Head to https://manukora.com/DIGEST to get $70 off the Starter Kit → Ollie | Ollie. Feed the Obsession. Go to https://ollie.com/digest and use code digest to get 60% off your first box! → Kasandrinos | Go to https://www.kasandrinos.com/digest and use code DIGEST for 25% off Timestamps: → 00:00:00 - Introduction → 00:05:52 - Rapid fire questions → 00:07:01 - Pregnancy without a period → 00:10:14 - Pregnancy postpartum → 00:11:51 - Functional hypothalamic amenorrhea → 00:15:01 - Infertility + IVF → 00:20:20 - Common IVF scenarios → 00:22:41 - THC products + fertility → 00:24:13 - Infertility as a symptom → 00:30:03 - Health + infertility → 00:36:43 - Detox pathways → 00:38:09 - Nutrient deficiencies → 00:40:22 - AMH + fertility → 00:45:28 - Inherited fertility factors → 00:48:22 - Birth control + fertility → 00:55:27 - Common fertility barriers Further Listening: → Foods That Help & Harm Hormones, Infertility, Inflammation, + The Key to Hormone Balance Check Out Dr Natalie Crawford: → Instagram → Website → Her book, The Fertility Formula Check Out Bethany: → Bethany's Instagram: @lilsipper → YouTube → Bethany's Website → Discounts & My Favorite Products → My Digestive Support Protein Powder → Gut Reset Book  → Get my Newsletters (Friday Finds) Learn more about your ad choices. Visit megaphone.fm/adchoices

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Joaquin Wallace.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Joaquin Wallace.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Joaquin Wallace.

Last night’s State of the Union Address was, though indirectly, in many ways largely indicative of the ‘State of our Union’; irascible, beleaguered, gaslighted, schizophrenic. Despite getting sidetracked for a bit on today’s episode, below you’ll find my extensive coverage of last night’s SOTU, including a timestamped breakdown of my live observations while watching. You’re sure to find some things the MSM has obfuscated or ignored… #Links American civil religion, ceremonial deism, apotheosis American civil religion – Wikipedia The Apotheosis of Washington – Wikipedia Ceremonial deism – Wikipedia Biblical Religion and Civil Religion in America by Robert N. Bellah The Network / Enterprise / Octopus Unlimited Hangout podcast, Ep. #37, One Nation Under Blackmail[1] Bruce Hemmings quote 37-Audiogram.mp4 Linda McMahon – Wikipedia #SOTU 2026 Coverage Online sources: Video: C-SPAN LIVE: Trump delivers State of the Union address (full speech) – AP – YouTube Video + Transcript: Donald Trump: State of the Union Address – Roll Call SOTU Donald Trump: State of the Union Address – Roll Call Donald Trump’s State of the Union Address, 2026 – Ballotpedia President Donald J. Trump’s 2026 State of the Union Address – The White House – YouTube President Trump 2026 State of the Union Address & Democratic Response – C-SPAN – YouTube WATCH: Trump delivers State of the Union address, Va Gov. Spanberger gives Dem response – Fox News – YouTube Rebuttal Democratic Response to State of the Union Address | Video | C-SPAN.org State of the Union Democratic Response: Virginia Gov. Abigail Spanberger to deliver party’s rebuttal | FOX 5 DC Reaction Pelosi Joins CNN Following The State of The Union Address – Nancy Pelosi – YouTube WATCH: Key moments from Trump’s 2026 State of the Union – PBS NewsHour – YouTube Key moments from Trump’s State of the Union – Washington Post – YouTube Jimmy Kimmel Reacts to Donald Trump’s State of the Union Address 2026 – Jimmy Kimmel Live – YouTube Pod Save America Hosts on Trump’s State of the Union, the Epstein Files & Writing Speeches for Obama – Jimmy Kimmel Live – YouTube LIVE Monologue: A Dark Speech Filled With Divisive Lies | USA Women’s Hockey Gets A Better Offer – The Late Show with Stephen Colbert – YouTube Fact-Checking Fact checking Trump’s State of the Union address | CNN Politics PolitiFact | Live fact-check: Donald Trump’s 2026 State of the Union address Fact-checking Trump’s State of the Union address | ABC News Fact checking Trump’s SOTU speech live: His remarks on Iran, tariffs, ICE, Supreme Court, and more | Hindustan Times Live fact-checking Trump’s 2026 State of the Union address | PBS News Follow PolitiFact’s live fact-check of President Donald Trump’s State of the Union – Poynter A look at Trump’s false and misleading claims in his State of the Union address | AP News Fact checking President Trump’s State of the Union address A Pre-SOTU Guide to Trump’s Economic Claims – FactCheck.org The State of the Union (According to Trump): Live Updates Protests Democratic Lawmakers Protest Pres. Trump’s State of the Union Address | Video | C-SPAN.org Celebrities, Lawmakers & Fmr. Gov’t Officials Gather to Protest State of the Union Address | Video | C-SPAN.org WATCH LIVE: Epstein survivors join House Democrats ahead of Trump’s State of the Union – PBS NewsHour – YouTube Epstein Saga Lawmakers & Epstein Survivors Hold Briefing Ahead of State of the Union | Video | C-SPAN.org Epstein Abuse Survivor Attending State of the Union Asks, “Where Are the Rest of the Files?” | Video | C-SPAN.org SOTU Related Headlines Trump boasts of a ‘golden age’ in State of the Union amid sharp partisan divisions | LA Times Trump says State of the Union will be ‘long speech’: What’s the record? | The Hill Trump set an all-time record with his second joint address on March 4, 2025, clocking in at one hour, 39 minutes and 32 seconds. Viewers disturbed by Trump’s ‘joyous look’ describing graphic violence and murder | Alternet Iran reacts to Trump’s 2026 State of the Union, accuses him of “big lies” | CBS News Trump brutally shut down when he tried to give himself the Medal of Honor | The Mirror Woman severely injured by Trump’s ICE thrown out of State of the Union | Raw Story Trump’s stare down with Mark Kelly ignites MAGA meltdown | Alternet Trump defends immigration crackdown at State of Union as approval ratings plummet | LA Times Speechwriters split after Trump’s record-breaking SOTU: ‘Living in his own reality’ vs. ‘Resounding speech’ | Fox News Here are all the awards Trump announced during his State of the Union | CBS News Yelling Trump Gets Into Wild Screaming Match with Democrats | The Daily Beast I went to Trump’s State of the Union. This was the moment when the room’s mood shifted. | Business Insider Pelosi explains white buttons at State of the Union address | The Hill Takeaways from Trump’s State of the Union address to Congress | Reuters Other Headlines Regarding the ‘State of the Union’ Judge Aileen Cannon bars the release of special counsel report on Trump’s handling of classified documents | CNN Politics Ro Khanna Claimed Epstein Visited ‘CIA Headquarters.’ It Was Almost Certainly An Hermès Design Studio. Another Black Man Found Hanging Quickly Ruled a Suicide Grandfather kidnapped from his bed and murdered in case of mistaken identity, police say 4 people fatally stabbed outside home near Seattle, suspect shot dead by deputy 2 Missouri deputies killed, 2 wounded after suspect opens fire Kristi Noem, DHS violated 1st Amendment by using facial recognition software to intimidate citizens observing them, complaint says Discord cuts ties with Peter Thiel–backed verification software after its code was found tied to U.S. surveillance efforts BMW to recall nearly 59,000 vehicles in US over damaged wiring harness, NHTSA says | Reuters US senators demand answers about utility companies’ ‘secret contracts’ with tech giants: ‘Forcing local communities to sign NDAs’ Bill Gates admits he had 2 affairs with Russian women, apologizes to staff over Jeffrey Epstein ties Trump’s ICE Is Quietly Stockpiling Weaponry—and It Should Alarm Us All Trump Administration Moves to Allow Intelligence Agencies Easier Access to Law Enforcement Files Son turns on his lawmaker dad for using ‘Epstein loophole’ to avoid jail for allegedly touching kids: ‘Inexplicable trauma’ ‘This should terrify you’: Meta Superintelligence safety director lost control of her AI agent—it deleted her emails Nearly two-thirds of companies have lost track of their data just as they’re letting AI in through the front door to wander around #Fact Check Drawn from CNN’s Fact checking Trump’s State of the Union address. For more balanced, detailed coverage, see PolitiFact article. Claim Rebuttal Source Rebuttal ‘$18 trillion’ in investments CNN’s Daniel Dale “…the White House’s own website said the figure for “major investment announcements” during this Trump term was “$9.7 trillion,” and even that is a major exaggeration; a detailed CNN review in [Oct 2025] found [WH counting trillions in] vague investment pledges, pledges that were about “bilateral trade” or “economic exchange” rather than investment in the US and vague statements that didn’t even rise to the level of pledges.” Low gas prices (2.30, 1.99, 1.85) CNN’s Daniel Dale According to AAA: only 2 states w/ avg < $2.50/gal; GasBuddy: 4:150k (.003%) gas stations w/ gas < $2/gal Inherited record inflation CNN’s Daniel Dale Dec, 2024 Y-O-Y inflation (CPI): 2.9% Inherited stagnant economy CNN’s Daniel Dale False (see details) Passed largest tax cuts (GBBB) in American history CNN’s Tami Luhby “It ranks seventh in terms of share of GDP since 1918, according to Chris Towner, policy director for the Committee for a Responsible Federal Budget, a nonpartisan watchdog group.” Biden allowed ‘11,888 murderers’ to enter US as migrants CNN’s Daniel Dale ““11,888” number is about non-citizens who entered the US not just under Biden but over the course of multiple decades, including during Trump’s own first administration.” Foreign countries are paying T47 tariffs CNN’s Daniel Dale “In an analysis released in February, officials at the Federal Reserve Bank of New York wrote, “We find that nearly 90 percent of the tariffs’ economic burden fell on U.S. firms and consumers.”…[CBO] wrote in a February report that “the net effect of tariffs is to raise U.S. consumer prices by the full portion of the cost of the tariffs borne domestically (95 percent)”…” Fraud in Minnesota CNN’s Daniel Dale “…Walz admin official said in December that they had “evidence of tens of millions of dollars in fraud to this point,” not $9[/18/19] billion…” US elections claims CNN’s Daniel Dale Disputed (see details) More Americans are working today than ever CNN’s Daniel Dale “The labor force participation rate, which measures the percentage of the population that is employed or actively looking for work, has been almost unchanged…” Ended eight wars CNN’s Daniel Dale Largely disputed (see details) Achieved no tax on Social Security CNN’s Tami Luhby Disputed, misleading (see details) Balancing the federal budget by ending fraud CNN’s Tami Luhby 2024 GAO estimate “found that [$233–521B] is lost to fraud annually. But the federal budget deficit came in at just under $1.8 trillion for the most recent fiscal year, which ended in September, according to the Treasury Department – more than triple the highest estimated fraud total.” #Contemporaneous Notes Duration: 01:47:43 (longest SOTU in history – breaking the modern record he set last year.) Timestamp (approx. w/ lag) CH Notes N/A No mention of Epstein or Trump / Epstein Files! Despite many survivors in chamber. No mention of Renee Good, Alex Pretti. T19:13:57-07:00 …our nation is back, bigger, better, richer and stronger than ever before. T19:13:58-07:00 “This is the Golden age of America.” T19:14:36-07:00 “…we have achieved a transformation like no one has ever seen before and a turnaround for the ages. It is indeed a turnaround for the ages.” T19:15:04-07:00 And we will never go back to where we were just a very short time ago. We’re not going back. T19:16:03-07:00 “Illegal aliens” / border T19:16:35-07:00 past 9 mo “ZERO illegal aliens admitted” T19:18:22-07:00 Inflation: 1.7% T19:18:37-07:00 Gas as low as 2.30 – 1.99 – 1.85 T19:19:08-07:00 Mortgage rates T19:20:25-07:00 $18T [in foreign investment] “pouring in from all over the globe.” T19:21:14-07:00 70k new construction jobs (AI Data centers?) T19:21:34-07:00 Oil, ‘new partner’, Venezuela: 80M barrels of oil T19:22:35-07:00 100% of all new jobs created, private sector T19:22:42-07:00 We ended DEI in America T19:23:32-07:00 The State of our Union is Strong T19:23:43-07:00 Our country is winning again. In fact, we’re winning so much that we really don’t know what to do about it. People are asking me, please, please, please, Mr. President, we’re winning too much. We can’t take it anymore. We’re not used to winning in our country. Until you came along, we were just always losing, but now we’re winning too much. And I say no, no, no, you’re going to win again. You’re going to win big; you’re going to win bigger than ever. (Narcissistic rant) T19:24:40-07:00 U.S. Men’s Olympic (Gold Medal) Hockey Team… Connor Hellebuyck… T19:26:22-07:00 U.S. Women’s Olympic hockey team “will soon be coming to the White House” (the team declined invitation to attend WH SOTU)[2][3] T19:28:57-07:00 I will soon be presenting Connor with … the highest civilian honor in our country, the Presidential Medal of Freedom T19:31:05-07:00 World Cup and Olympics coming to America T19:36:20-07:00 …government answers to the people, not the powerful… T19:37:27-07:00 GBBB, Republicans voted for it, all Democrats voted against it. T19:38:04-07:00 only if car is made in America T19:38:29-07:00 Megan [Hemhauser]’s story (child tax credit) T19:39:44-07:00 Trump Accounts, “Tax-free child investment accounts”, supporters; Michael & Susan Dell, Brad Gerstner (“hedge fund mgr”, founder, Altimeter Capital) T19:41:14-07:00 “$100k by the time they turn 18 – or a lot more (Uh…??) – go to TrumpAccounts.gov” T19:41:55-07:00 Dow hit 50k, S&P hit 7k T19:43:43-07:00 Tariffs: ‘country-saving, peace-protecting, time-tested and approved’… taking the great financial burden off the people… T19:44:47-07:00 A POTUS who put’s America first. I love America T19:45:11-07:00 For decades before I came along… T19:45:47-07:00 11,888 (illegal alien) murders T19:46:46-07:00 “They [Democrats] knew their statements were a dirty, rotten, lie.” T19:47:13-07:00 ” The cost of chicken, butter, fruit, hotels, automobiles, rent, is lower today than when I took office, by a lot. And even beef, which was very high, is starting to come down significantly.” T19:47:56-07:00 Crushing cost of healthcare. I want to stop large pmts to healthcare co’s, and give it to the people. (Isn’t it already the peoples’ money??) T19:49:25-07:00 Deflating prescription drug costs… Other presidents said they would, tried… didn’t do it… I got it done… T19:50:29-07:00 “So in my first year of the second term, should be my third term, but strange things happen.” (doublespeak, like Whitney Webb’s Bruce Hemmings quote[1:1]) T19:50:54-07:00 “… price differences of 300, 400, 500, 600 percent and more, (impossible) all available right now at a new website called TrumpRX.gov – and I didn’t name that one either, BTW.” T19:51:15-07:00 Catherine Rayner (IVF) story T19:54:34-07:00 We want homes for people, not corporations T19:54:49-07:00 Making it easier for people to save. Protecting Social Security & Medicare T19:55:24-07:00 Avg. 401k bal up $30k (How the AF can they possibly know that??? WH / POTUS should NOT know those numbers! If they know that, what else do they know??) T19:56:11-07:00 Members of Congress should not benefit (What about WH & friends???) from using inside information (ironic! Based on last point) Pass the Insider Trading Act right away. T19:57:19-07:00 MN – members of Somali community pillaging community, $19B. War on Fraud to be led by JD Vance. T19:59:32-07:00 Dalilah Coleman’s story (child, hit by illegal alien w/ CDL – interesting NOTE: spelling variations: Delilah / Dalilah Law) T20:01:34-07:00 Angel moms & families. Lizbeth Medina’s story (stabbed 25+ times by Rafeal Govea Romero) T20:04:00-07:00 Democrat(‘s) shutdown. Helping people clean up the snow. T20:05:20-07:00 First responsibility of American Gov is to protect American citizens, not illegal aliens. T20:07:13-07:00 You should be ashamed of yourself for not standing up (Heckling: Justice Democrats [Omar, Tlaib][4][5][6][7] primarily shouting back) T20:08:11-07:00 I’m asking you to approve the SAVE America Act. It’s very simple: all voters must show voter ID, proof of citizenship to vote. No more crooked mail-in ballots, except for… Polling at 89%, incl Dems. Even Communist NY Mayor wants shovelers to show 2 forms of ID + SS card T20:11:37-07:00 Sage Blair (& mom, Michelle), gender transition story T20:13:47-07:00 Look – nobody stands up. These people are crazy. … Democrats have destroyed the country. But we’ve stopped it, just in time. T20:14:27-07:00 First Lady – now a movie star. T20:15:29-07:00 Sierra Burns (Melania Trump Foster Youth to Independence Program participant) and Everest Nevraumont (11-year-old Alpha School student, AI-advocate, and TedX speaker) representing Melania Trump’s BE BEST Fostering the Future initiative.[8] T20:16:22-07:00 [Then, immediately after] …Christianity, and belief in God. … My great friend, Charlie Kirk. … martyred… Erika is with us tonight. [Fake Tammy Faye tears – and did she mouth ‘I miss you’ to Trump??] T20:17:35-07:00 America is one nation under God, and we must reject political violence of any kind T20:17:59-07:00 We love religion. It’s making a great comeback T20:18:50-07:00 [Aug 22, 2025 killing of 23-year-old Ukrainian refugee] Iryna Zarutska T20:20:41-07:00 Starting last summer, I deployed National Guard and federal law enforcement to restore law and order to our most dangerous cities, incl.; Memphis TN, New Orleans LA, Washington DC T20:22:15-07:00 Sarah Beckstrom’s story T20:27:23-07:00 In my first 10 months I ended eight wars, incl.; (1) Cambodia and Thailand, (2) Pakistan and India, (3) Kosovo and Serbia, (4) Israel and Iran, 5 Egypt and Ethiopia, (6) Armenia and Azerbaijan, (7) the Congo and Rwanda “and, of course, (8) the war in Gaza”. Isn’t it funny? They’re sick people. Cambodia and Thailand… Thank you Steve Witkoff and Jared Kushner for your help. And I also want to thank the man they report to; Sec. of State, Marco Rubio. … I think he’ll go down as the best ever. Under the cease fire, every hostage, living & dead, has been returned home. T20:31:42-07:00 And we’re working very hard to end the ninth war, the killing and slaughter between Russia and Ukraine… 25k soldiers die each mo. T20:32:12-07:00 Operation Midnight Hammer (Iranian attack) T20:33:57-07:00 [Iran] building weapons that will soon reach America… Renewing their sinister efforts… We haven’t heard those words; ‘We will never have a weapon…’ I will never allow the world’s #1 sponsor of terror (U.S.?!?) to have a nuclear weapon. (Are we de-nuking, then???) T20:35:43-07:00 we call ‘peace through strength’… and it’s been very effective. (and Orwellian) T20:38:06-07:00 We got a lotta money… (Really??? Not the American people???) T20:40:39-07:00 In January (Venezuela) …one of the most spectacular and impressive military feats. … Space Force is my baby. Nicolas Maduro, to face justice… New Pres. of Venezuela, Delcy Rodriguez. T20:42:24-07:00 Alejandra Gonzalez (Venezuela) and her uncle story. Uncle released – and here tonight! Enrique, please come down. … Thank you, Enrique. Have a good time. (CREEPY! Esp. since I was thinking ‘Epstein Files’ – unmentioned, BTW! – in back of mind as Alejandra & Enrique embraced, but mostly emotionless) T20:46:34-07:00 CWO Eric Slover (Venezuelan invasion) story, wife Amy [Slover]‘s holy water… Nation’s highest military award: Congressional Medal of Honor T20:50:19-07:00 Met w/ [Slovers] at Fort Bragg – we got the name back. … Eric’s fellow warriors will soon be receiving awards @ WH. T20:51:14-07:00 One last living legend to honor before we go… WWII / Korean ‘War’ Navy pilot, Royce Williams (100 yr-old): Congressional Medal of Honor T20:54:54-07:00 [Draft dodger!] I’ve always wanted the Congressional Medal of Honor, they say I can’t give it to myself. But, if they ever open that up… T20:58:18-07:00 “And when God needs a nation to work his miracles, He knows exactly who to ask. There is no challenge Americans cannot overcome, no frontier too vast for us to conquer, no dream too bold for us to chase, no horizon too distant for us to claim. For our destiny is written by the hand of Providence and these first 250 years were just the beginning.” T20:59:07-07:00 From TX to MI to FL to Dakotas, from Philly to DC, “the Golden Age of America is upon us.” The Revolution that began in 1776 has not ended… b/c Flame of Liberty and independence still burns… Thank you, God Bless you, and God Bless America. #Footnotes Unlimited Hangout podcast with Whitney Webb, Ep. #37, One Nation Under Blackmail (Aug 10, 2022) ︎ ︎ Why Team USA women’s hockey turned down invitation to White House State of the Union address – Yahoo Sports ︎ Trump joked he is being forced to invite the women’s hockey team to DC. Now, they’ve turned down his request ︎ WATCH: Ilhan Omar, Rashida Tlaib Heckle Trump During State Of The Union, ‘You Killed Americans’ | US News – Times Now ︎ Ilhan Omar And Rashida Tlaib Leave State Of The Union Early After Heckling Trump ︎ ‘You have killed Americans’: Ilhan Omar tries to shout down Trump’s immigration attacks | CNN Politics ︎ Midwest ‘Squad’ members shout down Trump during GOP’s biggest State of the Union applause lines: ‘You’re killing Americans’ | The Independent ︎ First Lady Melania Trump’s State of the Union Guests Reflect Her Impact on Education, Tech, and the Foster Community – The White House ︎

Blood cancers are the fifth most common group of cancers in the UK. But for a small number of people, the condition may have an inherited genetic cause.  In this episode of Behind the Genes, we explore the role of genetics in blood cancer, and what an inherited risk means for patients and their families. Our guests explain what blood cancer is, how inherited factors can increase risk, and why multidisciplinary teamwork is key to supporting families. They also look ahead to future advances, from whole genome sequencing to prevention trials.  Our host Amanda Pichini, Clinical Director at Genomics England, is joined by:  Dr Katie Snape, Principal Clinician at Genomics England and Consultant Cancer Geneticist  Bev Speight, Principal Genetic Counsellor Dr Sarah Westbury, Consultant Haematologist “By doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.”  You can download the transcript or read it below. Amanda: Hello, and welcome to Behind the Genes.  Sarah: When we think about blood cancers, it's a whole range of different conditions and when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers but also the way that those cells function, and so the range of symptoms that people can get is really variable.  Amanda: I am your host, Amanda Pichini, clinical director at Genomics England and genetic counsellor.  Today I'll be joined by Dr Katie Snape, principal clinician at Genomics England and a consultant cancer geneticist in London, Bev Speight, a principal genetic counsellor in Cambridge, and Dr Sarah Westbury, and haematologist from Bristol.  They'll be talking about blood cancers and the inherited factors that increase blood cancer risk.  If you enjoy this episode, we'd love your support, so please subscribe, rate and share on your favourite podcast app.  Let's get started.  Thanks to everyone for joining us today on this podcast, we're delighted to have so many experts in the room to talk to us about blood cancer.  I'd love to start with each of you introducing yourself and telling us and the listeners a little bit about your role, so, Sarah, could we start with you?  Sarah: Sure.  It's great to be here.  My name's Sarah Westbury, and I'm a consultant haematologist who works down in Bristol.  And my interest in this area is I'm a diagnostic haematologist so I work in the laboratories here in the hospitals, helping to make a diagnosis of blood cancer for people who are affected with these conditions.  And I also look after patients in clinic who have different forms of blood cancer, but particularly looking after families who have an inherited predisposition to developing blood cancer.  And in the other half of my job, I work as a researcher at the University of Bristol.  And in that part of my job, I'm interested in understanding the genetic basis of how blood counts are controlled and some of the factors that lead to loss of control of those normal blood counts and how the bone marrow functions and works.  Amanda: Thank you.  That's really interesting, we'll be looking forward to hearing more about your experience.  Bev, we'll come to you next.  Bev: Thank you.  Hello everyone, I'm Bev Speight, I'm a genetic counsellor, and I work at Addenbrooke's Hospital in Cambridge.  I work with families with hereditary cancers in the clinical genetic service, and for the last six years or so have been focused on hereditary blood cancers.  So we've been helping our haematologists across the region to do genetic tests and interpret the results, and then in my clinic seeing some of the onward referrals that come to clinical genetics after a hereditary cause for blood cancer is found.  I'm also part of the Council for the UK Cancer Genetics Group.  Amanda: Thank you, Bev.  And Katie, over to you.  Katie: Hello, I'm Katie Snape.  I'm a genetics doctor and I am a specialist in inherited cancer.  So we look after anyone who might have an increased chance of developing cancer in their lifetime due to genetic factors.  I am the chair of the UK Cancer Genetics Group, so that's a national organisation to try and improve the quality of care and care pathways for people with inherited cancer risk in the UK.  And I have a special interest in inherited blood cancers through my work at King's College Hospital, I work in the haematology medicine service there seeing individuals who might have or have been diagnosed as having an inherited component to their blood cancers.  So it's great to be here.  Amanda: Excellent, thank you for those introductions.  I'd like to then dive right in and understand a little bit more about blood cancers.  So, Sarah, could you tell us a little bit more about what blood cancer is?  Sarah: Yes, sure.  The term blood cancer is used to describe a whole range of different kinds of cancer, all of which affect some part of the blood or sometimes parts of the immune system that kind of gets represented as part of the blood.  So it's really describing a big group of conditions rather than one single kind of condition or entity itself.  But like any form of cancer, we understand blood cancers as being conditions where because cells as part of the blood system are rapidly dividing and normally doing so under really well controlled circumstances to produce just the right balance of blood cells and just the right number of those cells.  In a cancer affecting those cells, we see that that loss of control results in either too many of one type of blood cell being produced or too few, or that balance being lost.  And like any form of cancer, this is because of genetic changes that happen in individual cells that then go on to grow in a way that is not controlled and well regulated.    And because when we talk about blood cancer we're talking about such a wide range of different kinds of cancer affecting different cells within that blood system, there's a really wide range of different conditions.  From conditions that we might think of as being like a form of acute leukaemia, so something that produces often symptoms and signs in patients very quickly and they can often feel quite unwell quite soon and then get picked up with having this condition because they present feeling unwell.  All the way to chronic and slow growing cancers that can be found completely by chance and serendipity when blood tests are done for other reasons.  So when we think about blood cancers, it's a whole range of different conditions.  And when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers, but also the way that those cells function.  And so the range of symptoms that people can get is really variable, again depending on which of the blood cells are really affected by that.  And it may be that during the course of some of the conversations we have today in this podcast, we'll perhaps focus on particular kinds of blood cancer.  But like any cancer, it's that disruption of the normal growth and development of cells that means that the number and function of those blood cells has been disrupted in some way.  Amanda: Thank you so much for explaining that, Sarah, that's really helpful.  In terms of across the range of blood cancers, is that something that people can get at any age, and how common is it?  Sarah: It does depend, as we were sort of talking about that really wide range of different disorders that make up that group of blood cancers.  And individually each of those blood cancers is reasonably uncommon compared to cancers that we might typically think of, like breast cancer or colon cancer.  But actually, if you group blood cancers together, they make up quite a sizeable proportion, and they're actually as a group the fifth most common form of cancer that's diagnosed in people in the UK.  In adults in particular we think that perhaps people diagnosed with leukaemia would make up about 3% of the new diagnosis of cancer made in any year.  Amanda: So coming to you, Bev, when we talk about inherited blood cancers, what are the differences between those and blood cancers more generally?    Bev: So at point of diagnosis, it may not be obvious that somebody with a new blood cancer diagnosis is one of the minority of people in that big group as Sarah has described, who has an inherited cause.  So it may not be immediately obvious.  However, in the last few years certainly, it's become more and more routine to do quite broad genetic testing.  Often on a bone marrow sample or blood, because that is done looking for genetic changes, which are part of all cancer and we find within cancer cells, that can help with treatment planning.  It can also find that there is an inherited cause to that new blood cancer diagnosis.  Sometimes that might not be clear cut, sometimes that might be inferred from the genetic tests that are done on the blood or the bone marrow. And the proportion of blood cancers in that huge group which do have an inherited cause is fairly small, the actual proportion will depend a bit on the age of the patient and the specific subtype of blood cancer.  Amanda: Okay, and could you talk us through how some of those inherited genetic factors can increase the chance of a person developing blood cancer, how does that work?  Bev: Yes, so if we know that there is an inherited cause for blood cancer, then what we mean by that most of the time is that a change in a single gene has been found.  And that there is enough research evidence and enough known about that specific change in that gene to say to the person who's been diagnosed, there is at least in part or perhaps a full explanation for why that blood cancer has developed and this could be shared in the family.  So at that point it's information that not only has implications for the person in treatment, but also their relatives.  Depending on what sort of gene alteration it is and which gene it's found in, there are different inheritance patterns, and that changes the sorts of information that we give about risks for relatives.  So for lots of the genetic tests that detect an inherited cause in adults when they're diagnosed, that's most often what we would call an autosomal dominant inheritance pattern.  Essentially that means you only need to have one gene alteration which is in that person's normal non-cancerous DNA inherited from a parent and can be passed onto a child.  And for people in the family who have inherited this one genetic change, then they are likely to be at increased risk of developing blood cancer.  Sometimes with particularly the children's blood cancers, if an inherited cause is found, it can be a different pattern, which we call autosomal recessive.  And that's where two gene changes are found and one has been inherited from each parent.  So parents might be what we call carriers and have one each just by chance, both have been passed onto a child who has developed blood cancer either in childhood or possibly later on, and that's the pattern we call autosomal recessive.  There are other inheritance patterns too.  The third one that we come across being X-linked, and so that has a gender component.  That's where there's a change on the X chromosome, women have two X's, and men have one X and one Y.  So sometimes with the X-linked conditions we're more likely to see the clinical signs of a condition in boys and men because they've only got that one X chromosome.  But those are less common in the context of talking about hereditary blood cancers.  Amanda: Thank you.  That's really helpful to understand.  So it sounds like you're saying that these forms of blood cancers that are caused by a single gene are relatively rare.  And also by having one of these changes, it's not a given that that person will develop a blood cancer, but it makes them more likely, and how likely that is might depend on the inheritance pattern or the type of condition.  Bev: That's right.  So what we're saying is it can give either part of full explanation for the blood cancer diagnosis, and it could confer a risk to family members, but that doesn't mean they definitely will develop it.  We're talking about an increased risk compared to the population risk.  Amanda: Right.  I can imagine for those families to some extent it might be helpful to know the underlying reason why they had that blood cancer, but again, that's just a small proportion.  So, Katie, could I come to you next?  What about the rest of all the blood cancers, how do they occur?  Katie: Yes, thanks, Amanda.  So most blood cancers will occur just by chance.  We also know that there are some environmental factors that can increase the risk of blood cancers, so, for example, serious radiation exposure, something like that.  What Bev has described is where there is this sort of quite rare condition where there is a kind of single gene that's really important for the blood cells in terms of keeping those control mechanisms that Sarah described.  And that's not working properly, which has increased the risk of a blood cancer.  But we also sometimes see some families where there is more blood cancer, or the same type of blood cancer in that family than we might expect by chance.  We think that's probably not due to a single high risk genetic factor, but might be due to kind of multiple lower risk genetic factors that are sort of shared by close family members and can add up together to increase the risk a little bit.  And we call that familial risk or polygenic risk.  We don't have a test for that at the moment.  We wouldn't offer usually any extra screening or testing to those families, but we would just suggest obviously family members are aware of any signs of symptoms of blood cancers and seek any advice if they're concerned.  But, you know, the majority of blood cancers are not due to genetic factors, and it's sort of environmental or chance or bad luck. Amanda: Okay, so it's clear that obviously blood cancer is almost an oversimplification, within that category there's so many different types, so many ways that it could happen in a person.  So, Bev, if we're dealing with that type of blood cancer that is inherited or has some heritability, can you tell us more about what that means for the family?  What kind of impacts do you see that having for them?  Bev: Yes, of course.  So clearly this is another layer of information that's often coming at a family during a time where somebody is often recently diagnosed with blood cancer of one sort or another and is having to take in a lot of information about treatment and all of the uncertainty and anxiety that goes with that.  So for this minority of patients and families where there is new information about an inherited cause, that needs conveying in a timely but sensitive way, bearing in mind what else is happening.  And for some people it can come as a major shock and really an additional burden at that time.  I think the reaction to that will of course depend on lots of factors.  And what we also see is that this question about a new cancer diagnosis of any sort, including blood cancers, can generate the question in people's mind, particularly if they've got children, about does this change the risk for relatives?  So sometimes this new information that, actually, there is an inherited cause is an answer to a question that families have already got.  And that might be because of what Katie's described as familial clustering, there might already have been this known history in the family. So sometimes this information can feed into that and actually be quite a helpful answer.  But it's quite normal for families to feel quite mixed about this and for different family members to have a different approach to it.  When there's the offer of what we would call predictive testing, if we found a change in a single gene in somebody with blood cancer which we're saying is a hereditary cause for that, that might open the door for relatives to access predictive testing.  I.e., the opportunity to discuss and possibly take up a genetic test for themselves when they haven't had cancer themselves, but there's an opportunity to try and quantify whether or not they're at increased risk.  We know in families the uptake of those kinds of tests is different, and a lot of it is to do with timing and the way people respond to this in families might depend on their response to the cancer diagnosis in their relative, and of course what else is going on in their life at the time.  This aspect for the family is where clinical genetic services come in, because these initial tests in the person with blood cancer are done in their haematology/oncology setting, and normally the results about an inherited cause has been found are conveyed through that service.  That's when a referral to clinical genetics happens.  And in our specialist service we're addressing those additional concerns for the family which arise because of this diagnosis. Amanda: Thanks, Bev, for explaining that.  Sarah, coming back to you.  Could you tell me then if someone has an inherited blood cancer does it also change the way that the patient is treated? Sarah: Well, it certainly can do, and again, it does depend a little bit on the specific circumstances of that particular person and the form of inherited blood cancer predisposition that they have.  But certainly if we think about treatment as a whole, then for a lot of people it does affect the way that we might recommend treatments or look after them and their families.  So, for example, for some patients who have a diagnosis of an inherited form of blood cancer, we know that some treatments might be more or less effective for their particular set of circumstances.  And so that can sometimes influence the specific treatment recommendations that we would make, particularly thinking about, for example, the risks that the cancer might come back again after it's been treated.  Or thinking about whether or not some of the typical drug regimes that might be used might be perhaps more likely to cause them side effects or problems with tolerating that treatment.  So it can certainly make some changes in that respect. For some people, to be fair a minority of people with blood cancers, they may need a stem cell transplant as part of their treatment to hopefully cure them of their blood cancer.  And this as I say is a treatment that's required for a minority of patients as a whole who have a diagnosis of a blood cancer.  But for those people who have got an inherited predisposition and who might be recommended a stem cell transplant as part of their treatment, then knowing about a familial risk for this condition can also be really important.  For making sure that if a family member is being considered as a donor for example that we're being really careful to make sure that we're not choosing a donor that might also be affected by the same underlying blood cancer predisposition.  Because this can obviously cause problems for the person that's receiving the stem cells if it turns out that the person they're receiving them from actually has the same inherited condition as them.  So in that respect knowing about the underlying predisposition and genetic cause for their cancer can be helpful.  But in a more sort of general sense, yes, the other thing that it can have a big difference for is that some of these inherited cancer predispositions and syndromes also have other health conditions associated with them.  So it might be that that genetic diagnosis predisposes somebody not only to a form of blood cancer but to other health conditions as well.  And so actually knowing about that diagnosis can help their haematologist then make sure that they're linked in with the right other medical teams to make sure that those other health conditions are identified if they're present and taken care of.  And then I think really coming back to what Bev has already touched on, there's the sort of bigger picture of just how people are looked after in their own right but also as part of their family unit.  And making sure that they're given the right information and advice about their health, but also thinking about other family members.  And particularly for younger patients who perhaps either are just starting their own families or for whom that's not yet a consideration, making sure that they've got the information to understand what might be relevant for future family members, if that makes sense.  So it's not necessarily true to say that for every individual patient knowing that there's an inherited blood cancer present will necessarily directly affect the way that the treatment is offered.  But you can see that as a part of a bigger picture for a lot of patients, it will make a difference to their care as a whole.  Amanda: And you can really see how the impact is very sort of multigenerational and is going to affect people at all ages and stages of their life, so that's really interesting.  Katie, Bev spoke a little earlier about the fact that there are genetic tests that can help tell us if blood cancer is inherited.  Could you tell us more about what the tests involve, and some of your experience taking families through this?  Katie: There's sort of two main different ways that we might identify somebody has an inherited cause for their blood cancer through testing.  So traditionally what has happened, as Bev and Sarah sort of discussed before, is that when a person is diagnosed with a blood cancer, we either take a sample of their blood or bone marrow.  To try and look at what are the changes within those cells that have driven that cell to become a cancer cell and have driven this blood cancer to develop.  And a lot of the time, as we've said, it's not inherited, it's not genetic, so they're what we call acquired changes, they're changes that have just happened in the bone marrow or to the blood cells that have caused that kind of particular cell to become a cancer cell.  And it's really important that we look at those because that can help both diagnose the blood cancer, it can give us information about how serious that blood cancer might be, and it can also help us guide our treatments and therapies.  And so if we do those testings, they're primarily done within haematology for those sort of diagnostic or prognostic or treatment purposes.  We do sometimes see then a change that looks a bit suspicious that it might be inherited for various reason.  And if we see something that is in the cancer and it looks like there's a potential it could be inherited, we would go on and do a second test.  So usually because we can't do a blood test because the cancer's in the blood, we would take a skin biopsy.  And then we would look and see, well, is this change also present in the skin?  And if it is, then that indicates that that change is in all of the cells of the body, because it's in both the blood cancer and it's in the skin, and therefore it's likely to be inherited.  So that's one thing that we do.  And I think that that can be quite challenging for patients.  Because they go in to have a test for their blood cancer and then suddenly were being told, “Well, actually, we've also found something that might be inherited,” and it is something then that other members of the family might have.  And as Sarah said, potentially that means that even if your relative was offering to be a bone marrow donor for you, they might not be able to if they also carry the same thing.  And so that can be quite tricky just in terms of making sure that we're guiding the patient and their family members through that process.  And then thinking about the work that Genomics England does, particularly with whole genome sequencing, and this is particularly offered for children and young adults in the paediatric setting.  But I think we're also increasingly, as we progress we'll perhaps talk about this a bit, moving towards whole genome sequencing for adult blood cancers more routinely as well, that that is offered as a sort of standard of care.  And what whole genome sequencing is, is it is looking at the entire genetic instruction manual in both the blood cancer cells and in the cells that we're born with, to look at the inherited or germline genome as well.  And the reason that we look at both the cancer cells and the inherited or germline genome is because what we're trying to understand is firstly, are there any inherited changes that have led to the blood cancer developing?  But also, what are the changes that have just occurred in the cancer cells that are going to help us to diagnose and treat that blood cancer?  So by doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.  And so, again, when we're talking to patients, we have to explain to them that we're going to be looking at their entire genetic information.  And what's interesting about that is it might find things that are not only relevant to blood cancer, but very rarely other findings, incidental findings as well, or we might find things that we don't know about.  But I think certainly that's something that patients often feel very comfortable with having because it gives them the maximum amount of information.  Amanda: Thanks, Katie.  So it really sounds like there's a lot of advancements that are being made in genetic technology which potentially brings a lot of new things for you and Bev as genetic specialists, but also for you, Sarah, as a haematology specialist.  What does that kind of change for you, and I assume it's really important then for you all to be working together as a multidisciplinary team?  Katie: Yes, I mean, I think for clinical genetics, we were not involved in sort of haematology pathways for a really long time, and the haematologists are absolute experts in the genomic factors that drive blood cancers.  And certainly in my practice, it's really only been as the technology advanced that we really started finding more and more of these inherited factors, particularly in the adult setting.  Because I think in the paediatric and childhood setting, the haematologists again have been managing those conditions very well for years.  And I think there's places that we really interface and we really need to work together as a multidisciplinary team, understanding the genetic information, really understanding when something that we've seen in the blood cancer or the bone marrow could be inherited.  Do we need to check that?  What should that pathway look like?  But I think as you've said, a lot of these are actually really quite new conditions, particularly in the adult setting.  And we don't yet 100% know why do some people get blood cancer and some people don't when they have the same inherited factor.  What's the actual risk?  Are there any other factors modifying it?  What makes some people progress to develop a blood cancer and some people not?  And for that we really need to work together to try and gather the data and sort of capture people that have these inherited changes.  And hopefully develop a system and an infrastructure that we can follow it long-term and get a lot of information about long-term outcomes, both for individuals with cancer but also their families.  And also from looking at doing population studies.  Because I think we know that lots of people in the general population might carry some of these inherited changes and never develop a blood cancer as a result of this, certainly ones that seem a bit lower risk.  So we really need to work together to understand all of that.  But I'd be really interested in Sarah's views on that as well.  Sarah: Yes, sure.  So I think, as you say, Katie, haematologists have got a long history of understanding and interpreting genetic findings in the sort of acquired or somatic changes that we know are what occurs in some blood cells to drive the cancer forming in the first place. But this kind of newer integration of that with the germline testing is something that is becoming much more mainstream in haematology now, and I think something that people have had to sort of acquire new skills in this area to interpret that alongside.  I think as you say, that multidisciplinary working, where we're able to benefit from both sides of our expertise and knowledge and put that together is so valuable, particularly in those circumstances where there is some uncertainty.  And I think as a haematologist, one of the things that I really find a benefit both personally and professionally to help me navigate these tricky questions but that I also think patients benefit from is your expertise and ability to have those really quite tricky conversations with people who are not haematology patients, if that makes sense.  So they may be the relatives of patients who have a haematological diagnosis for example.  Who at the moment are entirely well and were just going about their daily business, and they're now told that they may or may not potentially have this inherited predisposition.  And I think that as haematologists, we're very used to dealing with potentially quite poorly patients, potentially quite scared patients who find themselves, you know, the recipient of all this quite difficult information.  But we're not necessarily so skilled and experienced at holding conversations with people who don't yet have that diagnosis.  And I think that that's a really rich area of mutual aid to one another as haematologists and genetic doctors, if that makes sense.  And I think your points about understanding actually the real risks and the nature history, as we would call it, of what happens to people who carry these variants that predispose them to blood cancers is something that we can probably only work out by working together.  And of course, working with the patients and families that are affected by these conditions so that hopefully for both sides in the future we'll be able to give much better advice to patients and their families.  Amanda: So, Bev, from your experience and as a genetic counsellor, what do you feel are the important things that patients and their families should know as they're going through this testing and diagnosis process?  Bev: The things I think families where there is a hereditary cause found should know is that with this new information comes a whole new referral to a dedicated service.  Who want to help patients and their family members at risk to navigate this, to adjust the information, and to make decisions that fit with them, about whether to have testing and the timing of that.  As we already said, where there is a hereditary blood cancer risk, that risk in family members is rarely 100%.  Depending on what the hereditary predisposition is in the family, we may be able to quantify that risk, sometimes we can't always.  And the other thing to know which links to that is that there is growing interest in research in this area.  That will really help us to improve care in terms of, for example, being able to quantify the risk of developing a blood cancer in relatives who are perfectly well that may have inherited these predisposition gene changes.  Or, for example, the other obvious place where we want to make improvements in terms of some sort of evidence-based surveillance for those people who want to find out that they have inherited the genetic change and are at increased risk.  Amanda: Thank you.  And overall there's been a lot I think we've been covering today that's probably going to be very new to many people.  Why do you think it's important to raise public awareness of inherited blood cancers?  Bev: There have been lots of public awareness campaigns about other cancers, as listeners probably can think about, in terms of for women checking their breasts and breast cancer awareness.  And perhaps there's been a bit less of that in general for blood cancers.  As we've already talked about, clinical genetics were not so involved in all of the genetic testing happening in blood cancers.  Because it wasn't so long ago in the history of how we think about inherited cancers in general that our suspicion of inherited causes in leukaemia was much lower than it is now.  So I think that awareness in the public probably will take a bit more effort to bring up.  But clearly public awareness about blood cancers in general, symptom awareness, and the fact that occasionally it can be something that is running in the family, clearly better public awareness of that means that people are empowered to ask the right questions.  And the questions that might already be in some way going through their minds of their haematology doctors or perhaps of their GP, if they've got a family history but are not affected themselves.  Amanda: Wonderful.  So, looking now to the future, Katie, what genomic advancements are we seeing or are we likely to see that could impact on the care of people with an increased genetic risk of blood cancer?  Katie: We touched a little bit, I think that whole genome sequencing is expanding.  And as we can turn that test around and get it back more quickly that might become more commonplace.  And I know Genomics England and the UK Haemato-oncology Network of Excellence have been doing a lot of work in that area.  We are very lucky now we have a national inherited cancer predisposition register that NHS England have set up with the National Disease Registration Service.  So that will enable us to capture individuals that have these sort of rarer but single gene disorders or conditions that increase the chance of developing blood cancers.  And that will enable us to do that sort of longer-term follow-up and get really more information.  We've touched on this already but I think there's really amazing research happening, why do some people develop blood cancers and some people don't, even though everyone carries the same underlying change that increases the risk?  And then I think really importantly, we're seeing now in some conditions, clinical trials of certain medications to see if that can actually prevent people who carry these inherited changes from progressing to developing blood cancers.  So I think all of those things are really exciting and will give us lots more information that we can then help patients and their families, particularly the sort of treatment and trials aspects.  Amanda: And, Sarah, on treatment and trials, how do think genomics might improve the treatment, but also the diagnosis of people with inherited blood cancers in the future?  Sarah: I think, you know, hopefully when we are able to accrue more information about these underlying genetic predispositions and how they actually then affect people's likelihood of developing blood cancer, we'll be able to build on what we have so far to make that just feel much more robust and evidence based.  And it feels like at the moment there are many of us struggling to bring together small threads of evidence that have been accrued in the UK but in other centres around the world that are also interested in understanding this inherited blood cancer risk.  In such a way that we can actually give patients and their families more clear information and advice about what that means to them.  And I think that in terms of the diagnosis of blood cancer, I think this is something that Bev alluded to.  If we could better understand who might benefit for example from having regular screening or monitoring blood tests performed to see whether we can detect an emerging blood cancer.  Versus identifying those people who actually, the chances of them developing a blood cancer are so small that doing those tests is likely to do them more harm than good.  Perhaps by just causing them to be anxious or have other sort of unintended consequences of that kind of testing.  So understanding something more about that natural history, as we've already alluded to, will hopefully improve our ability to go from the diagnosis of the predisposition condition to working out how to then diagnose the blood cancer on the back of that.  And with time, I think as Katie has alluded to, thinking about more specific treatments and more tailored treatments to the individual predisposition condition and the blood cancer.  So whether it's that you're intervening before the blood cancer has developed to try and reduce that happening, or whether it's that you're then treating the blood cancer after it's developed.  Understanding the genetic basis and what it is that causes that transition would be really helpful and I think that is something that will come but will take time.  And I think on a sort of national level what I would really hope to see over time is that we're able to use that improvement in evidence base to then be able to bring together perhaps more defined patient pathways.  So that if you're diagnosed with a particular condition, one of these leukaemia predisposition syndromes or another form of blood cancer predisposition, there's a recognised strategy and set of steps that should be taken for all of those patients.  To make sure that they're getting equity of care and make sure that everything is being done in a way that feels safe, sensible and appropriate across the country.  While still then enabling us to give really personalised treatment to that individual person and what that diagnosis means for them.  But I think until we've gathered more information and more evidence we are just in the process of trying to do that to then bring about those changes.   Amanda: If you enjoyed today's episode, we'd love your support.  So please subscribe, share and rate us on wherever you listen to your podcasts.  I've been your host, Amanda Pichini.  This podcast was produced by Deanna Barac and edited by Bill Griffin at Ventoux Digital.  Thank you for listening. 

Randy is back! After a break to welcome a new grandchild, Randy returns with a powerful and vulnerable episode that goes deep into the core of The Gap Thinking Framework. Why do we so often self-sabotage when faced with a new opportunity? Why is our first instinct to say, "I can't" or "I shouldn't"? Randy explains that the answer lies in our "BS" (Beliefs and Stories)—the subconscious programming from our past that dictates our automatic reactions. He shares a deeply personal story about how a "lack mindset" instilled in childhood has held him back for decades, and how it almost stopped him from pursuing a major new business venture just yesterday. In this episode, you'll learn how to identify when you are trapped in a "narrow gap" of old thinking and how to consciously widen that space to choose a different path. Randy challenges the idea that you need to know the "how" before you act, arguing that faith and a belief in your own ability to choose are the real keys to success. This is a masterclass in moving from being a habitual thinker on autopilot to becoming an active thinker who designs their own life. Mentioned in this episode: The Gap Thinking Framework, beliefs and stories (BS), self-sabotage, lack mindset, triggers, narrow vs. wide gap, faith, decision-making, Henry Ford quote, personal development. Ready to identify the patterns that are holding you back? Take the free Gap Thinking Framework Assessment at richmind.co     Key Takeaways: The Gap Thinking Framework is about controlling the critical split-second window between a trigger (stimulus) and your reaction. Most of our life is lived on autopilot, but we can't afford to let our big life decisions be made by habitual thinking. Your "BS" (Beliefs and Stories) are the subconscious programs, often formed in childhood, that dictate your automatic reactions to new opportunities. A "narrow gap" occurs when you instantly revert to old, safe beliefs of "I can't" or "I shouldn't," leading to self-sabotage. You don't need to know the "how" before you take action. The key is to step out in faith and belief, and the resources will appear. Randy shares a transparent example of being triggered by an old "lack mindset" while researching a new business venture and how he overcame it. The famous Henry Ford quote, "Whether you believe you can, or believe you can't, either way, you're correct," is the foundation of this episode.     Questions Answered in This Episode:   Why has there been a break in the podcast episodes? (Hint: A new grandbaby!) How do my childhood beliefs and stories affect my adult decisions? What is a "narrow gap" and how does it lead to self-sabotage? Why do I automatically think "I can't" when presented with a big opportunity? How can I stop letting my past define my future? What do I do when I'm triggered by fear and doubt? Why don't I need to know the full plan before I take the first step? How can I shift from being a "habitual thinker" to an "active thinker"?     Key People, Concepts, & Terms: People: Randy Wilson, Henry Ford, David Neagle. Concepts: The GAP, Gap Thinking Framework, Beliefs and Stories (BS), Self-Sabotage, Triggers, Patterns, Narrow Gap vs. Wide Gap, Habitual vs. Active Thinking, Faith, Lack Mindset, Abundance. Call to Action: Take the free Gap Thinking Framework Assessment at richmind.co

If you've ever worried about what happens to your family when a loved one passes, episode 406 of the Grief and Happiness podcast is essential listening. Inherited property expert Alexa Rosario reveals why 1 in 3 siblings never speak again after going through the inheritance process — and shares the framework she built after losing her own father to help families protect both their legacy and their relationships.In This Episode, You Will Learn:(00:58) Alexa's story: losing her father and the probate nightmare (04:56) Why inherited property is never logical — and attachment styles (10:12) The four "power vacuums" that open when a parent dies (15:02) How to start legacy conversations without the death talk (15:28) Why recipes and traditions are the real inheritance (20:50) Storyworth: capturing a loved one's memories (23:27) Discovering hidden family history through love letters (28:36) Inside Heirloom: from closure to legacy coronation (34:43) How to access Heirloom and find a trained agentAlexa Rosario is a South Florida-based real estate professional and founder of Heirloom, a platform that helps families navigate inherited property and senior transitions with both emotional intelligence and logistical precision. Licensed since 2013, it was the sudden loss of her father in 2018 — followed by a grueling probate process and the loss of her grandmother less than a year later — that set her on a mission to transform the way America inherits property. Her work has been featured in Yahoo Finance, Women of Influence, and SFBW, and she is actively training agents across the country to bring Heirloom's heart-led approach to more families nationwide.In this episode, Alexa and Emily explore what Alexa calls "the long grief" — the emotional and logistical weight that descends on families after a loved one passes. Alexa introduces four "power vacuums" that open during inheritance: the provision vacuum (financial systems that vanish with the person who managed them), the soul vacuum (loss of the family's tradition-keeper), the legacy vacuum (loss of the person who gave the family its identity), and the secrets vacuum (revelations that surface after someone is gone). She also connects attachment styles to sibling conflict during grief, and shares her six-part Estate Transition Framework — moving families from emotional closure through curation and the property decision, to a final "coronation" that helps carry traditions forward — all rooted in her belief that the true inheritance is never the property, but the memories and identity passed from one generation to the next.Connect with Alexa Rosario:WebsiteSubstackInstagramLinkedInBook: Alexa Rosario - The Legacy YearLet's Connect: WebsiteLinkedInFacebookInstagramTwitterPinterestThe Grief and Happiness AllianceBook: Emily Thiroux Threatt - Loving and Living Your Way Through Grief Hosted on Acast. See acast.com/privacy for more information.

If you were born into a Muslim family…Does that automatically make Islam true?In Episode 3 of Learning Islam from Scratch, a bold and uncomfortable question is asked openly:“What if Islam is wrong, and we believe in it only because we inherited it?”This episode explores faith beyond culture and geography — and examines whether Islam stands up to questioning.In this thoughtful father-daughter conversation, they discuss:• Whether truth depends on birthplace• Why Islam challenges blind inheritance• The Qur'an's invitation to reflect and question• The preservation and consistency of the Qur'an• Why Prophet Muhammad ﷺ could not have invented IslamThis episode approaches the topic with intellectual honesty and respect for all religions — showing that Islam does not fear examination.Faith inherited may be weak.Faith examined becomes conviction.

When Anna receives a heart transplant, she expects a second chance at life — not a front-row seat to someone else's. But the memories flooding in from her donor's past are growing darker by the day, and the line between whose life she's living is starting to disappear. | #RetroRadio EP0589CHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Show Open00:01:30.028 = CBS Radio Mystery Theater, “Bottom of the World” (May 06, 1977) ***WD00:46:45.398 = Dark Fantasy, “Death Is A Savage Deity” (January 30, 1942)01:10:41.532 = Fear on 4, “Tissue Memory” (October 16, 1997)01:38:55.808 = 5 Minute Mysteries, “The Postman Didn't Ring” (1947-1950)01:43:57.287 = Future Tense, “The Marian Death March” (May 07, 1974) ***WD02:11:30.677 = Crime and Peter Chambers, “Cemetery Attack” (April 20, 1954)02:34:49.178 = Hall of Fantasy, “The Judge's House” (July 04, 1947) ***WD03:01:06.379 = Haunted Tales of the Supernatural, “A Pair of Hands” (September 06, 1980) ***WD03:28:07.264 = The Haunting Hour, “The Mystery of the Southern Star” (September 29, 1945) ***WD03:55:35.476 = Hermit's Cave, “Reflected Image” (1937-1940s) ***WD04:20:47.961 = Mystery Is My Hobby, “Death Paints With Purple” (September 24, 1947)04:44:18.417 = Show Close(ADU) = Air Date Unknown(LQ) = Low Quality***WD = Remastered, edited, or cleaned up by Weird Darkness to make the episode more listenable. Audio may not be pristine, but it will be better than the original file which may have been unusable or more difficult to hear without editing.Weird Darkness theme by Alibi Music LibraryABOUT WEIRD DARKNESS: Weird Darkness is a true crime and paranormal podcast narrated by professional award-winning voice actor, Darren Marlar. Seven days per week, Weird Darkness focuses on all thing strange and macabre such as haunted locations, unsolved mysteries, true ghost stories, supernatural manifestations, urban legends, unsolved or cold case murders, conspiracy theories, and more. On Thursdays, this scary stories podcast features horror fiction along with the occasional creepypasta. Weird Darkness has been named one of the “Best 20 Storytellers in Podcasting” by Podcast Business Journal. Listeners have described the show as a cross between “Coast to Coast” with Art Bell, “The Twilight Zone” with Rod Serling, “Unsolved Mysteries” with Robert Stack, and “In Search Of” with Leonard Nimoy.= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2025, Weird Darkness.= = = = =#ParanormalRadio #ScienceFiction #OldTimeRadio #OTR #OTRHorror #ClassicRadioShows #HorrorRadioShows #VintageRadioDramas #WeirdDarknessCUSTOM WEBPAGE: https://weirddarkness.com/WDRR0589

Jewish Journeys, an unprecedented population study of Jewish Americans' perspectives on psychedelics, explores the attitudes, practices, and needs of the emerging Jewish psychedelic community in the United States. Zac Kamenetz and Josh Lipson join Dan and Lex for a conversation about this study, its implications for American Judaism, and how we might take lessons from the field of psychedelics and apply them to contemporary Jewish life. Head to JudaismUnbound.com/classes to check out our up upcoming courses in the UnYeshiva! This time around we are offering courses on an Intro to Judaism (Judaism Inbound), the book of Genesis, the Magic & Medicine of Psalms, Jews and Revolution, and a Jewish embrace of Fatness! Access full shownotes for this episode via this link. If you're enjoying Judaism Unbound, please help us keep things going with a one-time or monthly tax-deductible donation -- support Judaism Unbound by clicking here! Join the Judaism Unbound discord, where you can interact with Judaism Unbound's hosts, and with fellow listeners all around the world, by heading to discord.judaismunbound.com. 

When a parent passes away, emotions and finances tend to collide, especially when real estate is involved. One of the most common things that stalls families is fear of taxes, even when that fear isn't fully understood. Today's listener question is about an inherited home and hesitant siblings.   Show Links & Info: SPC Investing: http://spcinvesting.com/   Schedule A Visit: https://talkstomike.com/

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Heather Younger. Founder and CEO of a leading employee engagement and workplace culture consulting firm:

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Heather Younger. Founder and CEO of a leading employee engagement and workplace culture consulting firm:

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Heather Younger. Founder and CEO of a leading employee engagement and workplace culture consulting firm:

Jim and Chris discuss listener emails on Medicare Part B decisions for retirees abroad, Social Security survivor benefit surprises, inherited Roth IRA distribution rules, and balancing Treasuries versus annuities when “safety” is more emotional than mathematical. (6:45) A listener asks about situations where it might make sense to skip Medicare Part B, including retirees living abroad with strong foreign coverage and people who move to the U.S. later in life and must pay for Parts A and B. (33:30) George asks why some widows and widowers don't end up receiving the full benefit their spouse was receiving, even when the surviving spouse's payment increases after the death. (52:30) The guys respond to a question about whether an inherited Roth IRA requires annual distributions when the original owner was old enough to have RMDs, or whether the beneficiary can wait until year 10. (1:11:00) Jim and Chris revisit the annuities versus Treasuries discussion through the lens of fear and peace of mind, including why someone might emotionally trust Treasuries more than insurer guarantees even if the math favors SPIAs. The post Medicare, Social Security, Inherited Roth, Annuities: Q&A #2607 appeared first on The Retirement and IRA Show.

Send a textIn this episode, I'm pulling back the curtain on the lies we've all absorbed from our families, society, and culture. These beliefs feel like truth because we soaked them up before we could even question them. But here's the thing: they're not yours, and they don't have to run your life.What We Cover:The Patriarchy Wake-Up Call How a random conversation revealed my own inherited patriarchal programming (spoiler: it was humbling as fuck)Common Inherited Lies We All Believe:Money doesn't grow on treesRich people are selfish/unethicalHard work is the ONLY way to make moneyYour body needs to be fixed/controlledYou need to heal more before you can succeedLove means sacrificeIf you're not struggling, you're being selfishWhere These Beliefs Come From We inherit operating systems from caregivers, society, schools, and social circles, absorbing them when our brains weren't developed enough to question themHow to Spot What's Not Yours:Disproportionate reactions to small triggers"That's just how it is" thinkingPatterns repeating through generationsUnspoken family rulesThe Work: How to Dismantle Inherited Lies Byron Katie's four questions that'll flip your limiting beliefs on their head:Is it true?Is it absolutely, irrevocably true?How do you react when you believe that thought?Who would you be without that thought?Plus the turnaround—finding evidence that the opposite is possibleYour Brain Loves EvidenceWant to rewire a belief? Feed your brain proof that something else is possible. That's where the magic happens.Ready to Go Deeper?Join the Worthy AF Experience starting February 23rd. 4 weeks of dismantling the beliefs standing between you and the life you deserve. You'll walk away with workbooks, journal prompts, and actual tools to use anytime limiting beliefs try to run the show.FREE 7-Day Self-Worth Glow-Up Challenge starts Valentine's Day (February 14th). Seven days of overhauling your sense of self-worth. Join NOW!Connect With Me:Instagram: @shalvikap SubstackYouTubeSupport the show

Book an appointment with Phil to get your customized planning process started ➟ https://www.afswealthmgt.com/schedule-appointment Inheriting a home often brings more questions than answers, especially when taxes enter the conversation. Many families delay decisions because they're afraid of making an expensive mistake. Phil clears up common misconceptions and explains why the tax outcome is often very different than people expect. If an inherited property is creating stress or uncertainty in your family, Phil shares some much-needed clarity. Here's some of what we discuss in this episode:

In today's episode, Pastor Marron & Lady T continue the conversation from last week discussing cycles they've inherited from the way they were raised & how they've broken them in their single and married lives. Do you have a topic or question you'd like to hear addressed? Visit www.StillinLovePodcast.com. Subscribe to our channel | Innovation Church Memphis (Playlist -Still In Love Podcast) Follow us on social media | FB & IG - Innovation Church Memphis/PastorMarronThomas & on TikTok - WeAreInnovation

In this episode Brady opens up about one of the most defining experiences of his life, witnessing his father's descent into opiate addiction after a devastating car accident that nearly cost him his life.What began as a fight for survival turned into years of chronic pain, dependency, and emotional distance. Brady shares what it's like to watch someone you love struggle with pain and addiction while feeling completely powerless to help.In search of relief, Brady's father attended Eleusinia retreat focused on alternative pain management and healing. When he returned home, he encouraged Brady to go as well—an invitation that would ultimately change Brady's life, career, and relationship with his father forever.Brady reflects on how this experience reshaped his understanding of pain, healing, and leadership, and how it redirected his path in the mindset and fitness industry. This episode explores generational trauma, the limits of control, and how confronting pain can become a catalyst for profound personal growth.

Two Distinct Groups Showing How the Kingdom of God is Inherited 1) Unrighteous (vv. 9-10) 2) Rescued (v. 11)

Mortgages and Inherited Real Estate

Inheriting a home often comes with a lot of anxiety, especially around taxes. Many heirs assume selling means a massive tax bill, but that concern is often misplaced. In this episode, David breaks down what really happens when you inherit a house, why taxes are usually less painful than expected, and what non-tax issues can complicate the decision. If you're facing an inherited property, or expect to someday, this conversation brings clarity where many people feel overwhelmed. Here's some of what we discuss in this episode:

In today's episode, Pastor Marron & Lady T discuss cycles they've inherited from the way they were raised & how they've broken them in their single and married lives. Do you have a topic or question you'd like to hear addressed? Visit www.StillinLovePodcast.com. Subscribe to our channel | Innovation Church Memphis (Playlist -Still In Love Podcast) Follow us on social media | FB & IG - Innovation Church Memphis/PastorMarronThomas & on TikTok - WeAreInnovation

Shannon opens the show annoyed, reassures a sheepish Gary that he’s “safe,” and the two mock the idea of “house burping,” agreeing it’s just opening your windows. The hour turns serious as Gary & Shannon discuss the latest developments in the case of Savannah Guthrie's missing mother, including reports of blood at the scene and unanswered questions about a possible kidnapping.They also cover the Clintons agreeing to testify in the Epstein probe, unsettling reports of AI bots forming digital cults on Moltbook, and a lighter conversation about “inheritourism,” or how our vacation habits may be inherited from our parents.See omnystudio.com/listener for privacy information.

Wanna work with us? Schedule a call here: https://go.oncehub.com/bookacall Why We've Been Doing So Many Hard Money Refinances Lately - #323 Why are hard money refinances suddenly everywhere? In this episode of the Private Lenders Podcast, Chris and Jason break down the recent private lending refinance boom—what's driving it, why it's different from traditional refi cycles, and how private and hard money lenders can capitalize on these opportunities while managing risk. Unlike conventional refinance booms fueled by low interest rates, today's surge in hard money and private lending refinances is being driven by shifting capital markets, loans getting called due, tighter bank lending, and borrowers needing fast, flexible bridge capital. Chris and Jason share real-world case studies, including low-LTV refinances, free-and-clear rental properties, commercial properties, and situations where banks simply won't move fast enough. They also dig into: The pros and cons of hard money refinance loans Why exit strategy is the biggest risk in refi deals Cash vs. equity (and why it matters more than credit score) Inherited property refinances and why they're riskier than they look Common compliance pitfalls (consumer vs. business purpose loans) Why pulling credit and reviewing prior HUDs, notes, and deeds is critical When "payoff in cash" can actually be a realistic exit If you're a private lender, hard money lender, or real estate investor, this episode will help you better underwrite refinance deals, avoid costly mistakes, and spot opportunities others miss.

Thabang just started a new job at a bank and has already walked into workplace politics. The whole team seems to dislike one admin lady, Eliane, and there’s an unspoken expectation that he shouldn’t like her either. The twist? She’s actually been kind and welcoming to him. Now he’s stuck in that awkward new-guy position: fit in with the group or judge someone based on his own experience. It’s a classic case of inherited office drama, where new employees feel pressured to pick sides in issues they don’t fully understand. Hang out with Anele and The Club on 947 every weekday morning. Popular radio hosts Anele Mdoda, Frankie du Toit, Thembekile Mrototo, and Cindy Poluta take fun to the next level with the biggest guests, hottest conversations, feel-good vibes, and the best music to get you going! Kick-start your day with the most enjoyable way to wake up in Joburg. Connect with Anele and The Club on 947 via WhatsApp at 084 000 0947 or call the studio on 011 88 38 947Thank you for listening to the Anele and the Club podcast..Listen live on Primedia+ weekdays from 06:00 to 09:00 to Anele and the Club broadcast on 947 https://buff.ly/y34dh8Y For more from the show go to https://buff.ly/gyWKIkl or find all the catch-up podcasts here https://buff.ly/K59GRzu Subscribe to the 947s Weekly Newsletter https://buff.ly/hf9IuR9 Follow us on social media:947 on Facebook: https://www.facebook.com/947Joburg/ 947 on TikTok: https://www.tiktok.com/@947joburg947 on Instagram: https://www.instagram.com/947joburg947 on X: www.x.com/947 947 on YouTube: https://www.youtube.com/@947JoburgSee omnystudio.com/listener for privacy information.

Brendan Beachy - Sunday Morning Main Message

  The Masculinity We Inherited… And Why It Stops Working Most men didn't choose their model of masculinity. We absorbed it—through family, culture, locker rooms, workplaces, and silence. This episode was sparked by a long conversation between Andrew Huberman and therapist/author Terry Real about masculinity, emotional health, and relationships. What stood out wasn't a new, flashy idea—it was language. Language for something most men feel but don't always know how to name. This isn't a lecture. It's not political. It's three men thinking out loud about what works, what doesn't, and what might actually help. At AMG, the goal isn't perfection—it's practice. And we lead with curiosity over defensiveness. The Masculinity Model We Inherited Most of us were taught a version of masculinity that prizes: Stoicism Self-reliance Emotional restraint Vulnerability was framed—explicitly or implicitly—as weakness. The message wasn't always spoken, but it was clear: Handle it. Don't need too much. Don't feel too much. As Terry Real puts it (paraphrased): Avoiding vulnerability doesn't eliminate it—it follows you. What That Feels Like Internally For many men, this shows up physically before it shows up emotionally: A tight chest A clenched jaw Emotional narrowing And when emotions do surface, the vocabulary is limited. Most men were handed four options: fine, tired, stressed, or pissed. An AMG Practice Instead of defaulting to "I'm fine," practice naming what's actually there—even if it's clumsy at first. Reflection: What emotions felt unsafe or unwelcome growing up? The Cost No One Warned Us About The inherited model works—until it doesn't. Performance-based worth can drive achievement. But achievement delivers pleasure, not relational joy. Many men reach a confusing place where they are: Competent but disconnected Successful but quietly lonely Calm on the surface, angry underneath Anger often becomes the only "allowed" emotion because it still feels powerful. This isn't about becoming soft. It's about becoming more effective and more connected. At AMG, we don't just name behavior—we name cost. Reflection: Where has this model worked for you? Where has it quietly failed you? Redefining Strength What if vulnerability isn't a collapse—but a skill? Strength isn't the absence of discomfort. Strength is the capacity to stay present with it. This includes: Expressing needs clearly instead of controlling outcomes Naming truth without blame Allowing discomfort without shutting down Terry Real (paraphrased): Strength includes the capacity to identify and name our needs respectfully. Important Distinctions Oversharing vs. clean honesty Presence vs. emotional flooding Vulnerability vs. losing regulation Many men confuse control with strength—when in reality, control is often fear in disguise. Reflection: Where do you confuse control with strength? Relational Mindfulness & Healthy Distance Relational maturity isn't about reacting better—it's about noticing sooner. This means: Recognizing internal reactions before acting Taking space to regulate, not punish Returning to the relationship clean instead of armored Sometimes "I need space" quietly turns into a two-day blackout. That's not regulation—that's avoidance. At AMG, the practice is simple and demanding: Rest. Regulate. Return. When done well, you'll notice: A settling nervous system Reduced reactivity More honest connection Weekly Practice This week, notice one moment when you want to shut down or get defensive. Stay present 10 seconds longer than you normally would. No fixing. No explaining. Just presence. Reflection Questions What masculinity model did you inherit? Where is it costing you connection? What would strength-as-presence look like this week? What's Next In Episode 2, we'll explore: Ownership vs. self-blame Coping vs. numbing Brotherhood as a legitimate mental health strategy Because men don't heal in isolation—and they never have.  

I Inherited A Creationist Museum And To My Horror Some Were GenuineBecome a supporter of this podcast: https://www.spreaker.com/podcast/darkest-mysteries-online-the-strange-and-unusual-podcast-2026--5684156/support.Darkest Mysteries Online

Some struggles don't make sense.You do the work.You try to heal.And yet the same emotional patterns, grief, anxiety, or disconnection keep resurfacing.In this special Grief 2 Growth episode, Brian D. Smith welcomes back Dr. Lotte Valentin, medical doctor, psychotherapist, ancestral healer, and two-time near-death experiencer, for a profound conversation about inherited emotional patterns and why some challenges may not have started with you.Dr. Lotte shares how grief, trauma, and unresolved experiences can be passed down through generations—encoded not only in DNA, but in the nervous system, language, and subconscious. These patterns, she explains, often surface when someone in the family line finally has the awareness and capacity to heal them.✨ That may be why this conversation found you.

I Inherited A Creationist Museum And To My Horror Some Were GenuineBecome a supporter of this podcast: https://www.spreaker.com/podcast/darkest-mysteries-online-the-strange-and-unusual-podcast-2026--5684156/support.Darkest Mysteries Online

In this episode, we explore how life's challenges are not setbacks or punishments, but invitations to activate strengths already embedded within us. Together with Rabbi Michael Cohen, we examine Rav Dessler's understanding of mercy, testing, and inherited spiritual capacity, and how these ideas can change the way you experience difficulty. You'll gain a clearer way to face pressure without feeling broken or defeated, learn how to recognize when inner resistance is not “who you are,” and understand how integrity and lived choices reshape your inner world. If you've ever wondered why challenges keep appearing or how to stay aligned with truth when life pushes back, this episode offers a grounded framework for moving forward with clarity and confidence.Join the Conversation! Be part of our growing community—join the Shema Podcast for the Perplexed WhatsApp group to share feedback, discuss episodes, and suggest future topics. Click here to sign up.Connect with Rabbi Michael CohenReach out to Rabbi Michael Cohen to learn more about his one-on-one coaching work, where he applies the teachings of Strive for Truth to help individuals untangle inner confusion, clarify priorities, and live more grounded, self-expressed lives. To inquire or connect, email him at mailto:rabbicohen@msn.com. 

This is the fourth episode in the reignited series "Coaching for Transformation". This series will focus on unpacking the coaching strategies that help leaders grow into the best versions of themselves.This conversation is hosted by Dario Minaya, with insights from Susan Minaya, COO, Chief Learning Strategist and Executive couch with Minaya Learning Global Solutions. This episode will focus on leading inherited teams. Stay tuned to learn more.

Integrations look deceptively simple until they become the backbone of your business. In this episode of Between Product and Partnerships, Pandium CEO Cristina Flaschen sits down with Scott Lavery, Senior Product Manager at Arkestro. They unpack what really happens when integrations shift from a "nice to have" feature to something the company can't function without.Scott shares hard-earned lessons from a decade in B2B SaaS, covering sectors from martech to procurement. He discusses the headache of inheriting messy stacks and why iPaaS tools often hide long-term costs. The conversation also explores how integration work fundamentally changes what it means to be a product manager. Together, they dig into common failure modes and the tough tradeoffs junior PMs face when they're "volun-told" to own integrations.Who we sat down withScott Lavery is a Senior Product Manager at Arkestro. With over ten years of experience in B2B SaaS, he has repeatedly found himself responsible for integrations, often without ever intending to specialize in them.Scott brings expertise in:Unwinding complex iPaaS-driven environments.Designing integrations built to be "set and forget."Managing third-party dependencies alongside specific scale constraints.Advocating for pragmatic, cost-aware strategies.Key TopicsWhy integration PM work is fundamentally different Integration success is defined by invisibility. Unlike standard features, value is found in reliability and trust rather than how often a user clicks a button.The hidden costs of low-code and iPaaS tools Teams often end up writing code blocks inside "no-code" tools. We discuss how pricing models can distort architectural decisions and where velocity eventually hits a wall.What to do when you inherit a messy integration stack Practical advice for PMs walking into undocumented systems filled with inherited workflows and vendor dependencies they can't control.Episode Highlights01:48 - How most PMs “fall into” owning integrations03:58 - Why integration metrics flip traditional product thinking on its head06:31 - Contextual success metrics: Why volume is not the same as value08:21 - Navigating ecosystems without becoming a domain admin11:18 - Why API docs lie and customers ignore your design intent15:37 - Warning signs of an unhealthy iPaaS environment19:05 - Silent failures and the pain of hearing about outages from customers23:45 - The code-block paradox in low-code platforms31:52 - Scott's playbook for PMs inheriting integrationsKey TakeawaysGreat integrations are designed to disappear Successful integrations are rarely touched after the initial setup. In this space, reliability is a far more important metric than user engagement.Metrics are contextual, not universalA monthly sync can be just as vital as one that runs every five minutes. Frequency alone does not signal success.You can't abstract away real-world usage API contracts rarely reflect reality. No tool removes the need to understand how customers actually use systems like NetSuite or Salesforce.Low-code tools often trade speed for long-term pain Teams save time early but spend years optimizing around pricing models and managing fragile logic.Inherited workflows is a scalability risk If only one person understands the system, it is already brittle. This is a massive liability once customers are live.Silent failures erode trust fastest Learning about outages from customers is a major failure. Proactive monitoring and clear communication are bas

This episode explores why bold ideas so often fail not because they're wrong, but because they collide with expert identity, status, and narrative inertia. Drawing on Professor Angus Fletcher's work across literature, neuroscience, and elite military training, the conversation reveals how resistance forms...and how it can be softened without surrendering truth. We learn why timing, framing, and emotional security matter more than raw correctness when challenging entrenched thinkers. It's a practical guide for theorists, researchers, and creators who want their ideas to survive first contact and actually be heard.Part 2: https://youtu.be/_e8PDmutK0wPATREON https://www.patreon.com/c/demystifysciPARADOX LOST PRE-SALE: https://buy.stripe.com/7sY7sKdoN5d29eUdYddEs0bHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-herePARADIGM DRIFThttps://demystifysci.com/paradigm-drift-show00:00 Go! Narrative resistance and why new scientific ideas fail00:05:20 Inherited beliefs, status, and emotional security in science00:13:15 Why revolutions in science rarely start rigorously00:18:46 Consensus, utility, and the difference between science and truth00:24:30 Science as story: rationality, beauty, and belief00:32:30 Enchantment, myth, and magical thinking in science00:38:48 Making unsexy truths emotionally compelling00:47:10 Narrative intelligence vs modern science communication00:55:54 Isolation at the edge of expertise00:58:14 From neuroscience to narrative theory01:00:31 Why the military took narrative theory seriously01:05:53 Cranks, outsiders, and how breakthroughs get validated01:10:32 Why optimization fails for humans01:17:14 Narrative imagination vs creativity theory01:21:10 Roleplay as preparation for difficult conversations#consciousness , #humanbehavior, #creativity, #intelligence, #decisionmaking, #psychology, #meaning, #innovation, #learning, #thinking, #history, #philosophy, #communication, #leadership, #physicspodcast, #philosophypodcast MERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

For a long time, genetic conditions were treated as a verdict. As if a diagnosis, a family history, or a lab result quietly closes the door on what's possible.I see it every day. People sitting across from me asking, “Is this just how my body is? Is my family history my future? If this is genetic, does anything I do actually matter?”And the truth is, the answer isn't a simple yes or no. Genetics matter, and inflammatory and allergic conditions really are part of how we're wired. But here's what often gets missed. Genetics may load the risk, but they don't automatically determine how life plays out.I've cared for patients with the same diagnosis, similar histories, and even similar genetic risk, and their day-to-day reality can look completely different. And it's not because one tried harder or had “better” genes.It usually comes down to one thing - lifestyle intervention. Lifestyle doesn't change DNA, but it does influence how the body responds to a genetic risk. So the real question isn't “Are genetics destiny?” It's “How much room is there to work with what I've been given?”In this episode, I reflect on what it actually means to live with a genetically driven condition, how to stop chasing cures, and start working with your body for better long-term results. Things You'll Learn In This Episode Genetics explains risk, not destinyMany immune and inflammatory conditions are genetically driven, but why do people with the same diagnosis experience vastly different severity and stability?Lifestyle doesn't cure disease, but it regulates expressionSleep, stress, food, and movement don't change DNA, but how do they influence which inflammatory pathways get turned up or quieted?Stability is not failure; it's progressWhy do we chase cures in conditions that require management, and what happens when we redefine success as fewer flares, better control, and improved quality of life?Precision beats perfection in chronic immune healthIf moderation doesn't work for everyone, how do we learn to set boundaries that respect our unique biology instead of fighting it?About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Disclaimer ​​TLC presents this podcast as a means of information sharing only. This information is not intended to be medical advice or to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.

We live in a world that is in desperate need of peace and wholeness. Communities across the globe are ravaged by violence and instability, but what does it look like to be practitioners that seek to transform conflict into thriving communities. In this conversation, Brandon Stiver is joined by Prashan De Visser, the Founder and CEO of Global Unites. Prashan shares his insights on the impact of colonialism, civil war and poor governance in Sri Lanka and the role of the church can play in conflict transformation. He shares about the work of Global Unites in promoting peace and reconciliation in over 20 countries emphasizing the importance of nonviolence, grassroots movements, and youth leadership in conflict transformation. This conversation dives into the complexities and the unique hope that comes with youth movements for peace. Support the Show Through Venmo - @canopyintl Subscribe to Our New YouTube Channel Podcast Sponsors Take the free Core Elements Self-Assessment from the CAFO Research Center and tap into online courses with discount code 'TGDJ25' Take the Free Core Elements Self-Assessment Resources and Links from the show Global Unites Online Why Nations Fail by Daron Acemoglu and James A. Robinson Conversation Notes (AI Generated) The importance of creating an inclusive Sri Lankan identity and governance structure. The legacy of colonialism continues to affect Sri Lanka's social fabric. Nonviolence is a crucial principle for sustainable change in conflict situations. Grassroots movements are essential for effective peace building. Youth leadership is vital for the future of conflict transformation. Reconciliation involves healing, repairing, and transforming societal structures. Inherited prejudices can be dismantled through personal connections and experiences. The church has a significant role to play in promoting peace and reconciliation. Copy-paste solutions in conflict resolution often lead to more harm than good. Local expertise is invaluable in creating effective interventions for peace. Theme music Kirk Osamayo. Free Music Archive, CC BY License

Only around 18% of inherited metabolic diseases have disease-specific treatments, yet palliative care remains strikingly underused. In this episode, Anja Lee and Trine Tangeraas discuss a pan-European survey exploring access, barriers, and how earlier integration of palliative care can transform support for people living with IMDs. Palliative Care for Children and Adults With Inherited Metabolic Disease in Europe: An Underutilised Service for Supportive Treatment and Care Anja Lee, et al https://doi.org/10.1002/jimd.70095

Ramit Sethi of I Will Teach You To Be Rich talks to Mike and Noel, a young couple who are both 34. They married just 6 months ago, but financial fights have become a daily occurrence, even after receiving a $170K windfall. Mike blames Noel for overspending, but admits they both struggle with money, while Noel views the windfall as "guilt-free" spending. With $244K in debt, zero savings, and 82% of their income going to fixed costs, Ramit helps them uncover the root of their money woes. Will they finally get on the same page, create a financial system that works, and learn to trust each other with money? In this episode we uncover: • How Mike's money anxiety leads him to check his bank account 20 times a day • The shocking truth about their $170K windfall • Why Mike's anxiety worsens when he makes more money • The one money rule Mike and Noel both broke • How Mike's upbringing shaped his money habits • Why Noel feels like she's "drowning" and has no control over their finances • The spending categories that reveal their money psychology • Why Mike's "money is mine" mentality is holding them back • Noel's struggle to “hand over her paycheck” • The credit card debt that keeps piling up • Ramit's radical approach to cutting fixed costs • The “Glade Plug-in” budget that explains everything • Noel's difficult decision about tithing and faith • Why benchmarking against past mistakes is a recipe for disaster • The truth about their approach to money Chapters: (00:00:00) “We just kinda like get whatever we want whenever we want it” (00:07:02) “I was stressing more than ever before” (00:14:04) The one money rule they both broke (00:24:29) “You treat me like a child” (00:32:39) Ramit identifies their “money leaks” (00:39:34) “I don't want to hand over my paycheck” (00:47:30) “My goals are not being met” (00:55:38) The “Glade Plug-in” budget (01:00:03) “I do wanna have a Glade budget” (01:06:50) How Mike's upbringing shaped his money habits (01:15:10) Ramit shares his radical advice (01:21:10) Preview for part two This episode is brought to you by: Bilt | Join the loyalty program for renters at https://joinbilt.com/ramit Wispr Flow | Try Wispr Flow for free at wisprflow.ai/ramit Gelt | Book a tax consultation with Gelt at https://joingelt.com/ramit. As a member of my community, you can skip the waitlist Netsuite | Get the free guide “Demystifying AI” at https://netsuite.com/ramit Fabric by Gerber Life | Join the thousands of parents who trust Fabric to protect their family. Apply today in just minutes at https://meetfabric.com/ramit Connect with Ramit Get my new book, Money For Couples Get Money Coaching with Ramit  Download the Conscious Spending Plan Listen to my book—now on Audible Get my New York Times best-selling book Get my no-numbers journal Other episodes Instagram Twitter YouTube If you and your partner have a money issue and you want my help, I occasionally select a couple to work with, free of charge. Apply for my help here: https://iwt.com/apply

In this episode of Chilling Tales for Dark Nights, we explore the unseen weight of legacy—the quiet burdens we inherit, the warnings we dismiss, and the objects that outlive the people who once held them close. When grief draws someone back to a place they never meant to return to, the past proves unwilling to remain buried. What begins as a personal reckoning becomes something far more dangerous, as old boundaries blur and the line between memory and menace collapses. This is a story about what lingers, and about the cost of forgetting. To watch the podcast on YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/ChillingEntertainmentYT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Don't forget to subscribe to the podcast for free wherever you're listening or by using this link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/ChillingTalesPod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ If you like the show, telling a friend about it would be amazing! You can text, email, Tweet, or send this link to a friend: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/ChillingTalesPod⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Andrew Fillipponi joined Ken Carman and Anthony Lima to share his insight on Mike Tomlin and why Steelers fans want to see him fired. He also talked about why he doesn't think Tomlin would be a hot commodity around the league if he became available, and why he wouldn't want Kevin Stefanski to fill a potential head coaching vacancy in Pittsburgh.

Daniel de la Vega spotlights luxury real estate, saying it is acting as an alternative asset class for investors. He notes that it outpaced housing in 2025 and sees premium resilience. “Lifestyle's a big, big component of all of this.” The buyer base is global and motivated by wealth preservation, he argues, not worried about monthly payments and often paying in cash. He breaks down the Sotheby's Luxury Outlook Report, which highlights roughly $6 trillion inherited in 2025.======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Nadjeschda (Nadja) Taranczewski is a master of psychology, master certified coach, and founder of Conscious U who specializes in helping CEOs and founders uncover unconscious patterns shaping their relationship with wealth, leadership, and intergenerational trauma through her pioneering Money Work Program.3:00 - Nadja shares her powerful family history: her German grandmother's side benefited from the Nazi regime while remaining silent about their role, while her Polish grandmother was abducted and forced into prostitution, and her Russian grandfather was tortured in a concentration camp until he became an informant.8:00 - The profound impact of intergenerational trauma: Nadja's father grew up in extreme poverty with five people in a one-bedroom apartment, translating his grandfather's concentration camp stories at age 13, learning "the only person you can rely on is yourself."15:00 - Discovery process: Nadja pieced together her family story over decades through therapy and conversations, realizing that understanding these patterns was essential to breaking free from inherited trauma and beliefs about money and safety.25:00 - The concept of "source energy" - Nadja explains how we're born with original essence that gets overlaid with family patterns, cultural conditioning, and protective mechanisms, leading most people to live from a false self rather than their authentic core.35:00 - Money as safety vs. money as energy: Nadja contrasts her father's scarcity mindset ("money is safety") with her mother's guilt-driven giving, showing how both extremes kept her stuck until she learned to see money as flowing energy.45:00 - The three-step framework for transformation: noticing patterns, understanding their origins in your family story, and consciously choosing new responses that align with your true self rather than inherited programming.55:00 - Language shapes identity: Speaking multiple languages reveals how cultural context influences personality - English allows more optimistic expression while German and Polish carry historical weight and pessimism from generations of trauma.1:03:00 - Definition of success: "To have the luxury to realize my potential and to be more of myself in an environment where I get seen for that, celebrated for that, and loved for that."Podcast Program – Disclosure StatementBlue Infinitas Capital, LLC is a registered investment adviser and the opinions expressed by the Firm's employees and podcast guests on this show are their own and do not reflect the opinions of Blue Infinitas Capital, LLC. All statements and opinions expressed are based upon information considered reliable although it should not be relied upon as such. Any statements or opinions are subject to change without notice.Information presented is for educational purposes only and does not intend to make an offer or solicitation for the sale or purchase of any specific securities, investments, or investment strategies. Investments involve risk and unless otherwise stated, are not guaranteed.

Let us know what you thought about the show!In this episode, Jason speaks with Myra Salzer, CFP® & Melissa Hoyer, CFP®, CPCC of The Wealth Conservancy to explore how individuals navigating inherited or sudden wealth can shift from overwhelm to clarity, agency, and purpose. Rather than treating money as a purely financial matter, Myra and Melissa illuminate the emotional, psychological, and relational realities of wealth — and how aligning values with financial decisions can transform wealth into a meaningful ally rather than a burden.They discuss the unique identity challenges faced by inheritors, the central role of fiduciary responsibility, and the importance of proactive communication, legacy planning, and intentional philanthropy.Key Highlights & InsightsDecoding Financial Jargon — What the Terms Really MeanCertified Financial Planner (CFP®): A CFP® serves as a strategic integrator overseeing a client's entire financial ecosystem — taxes, estate strategy, insurance, investments, and long-term planning — rather than focusing only on asset management.Fiduciary Standard: A fiduciary is legally obligated to put the client's interests first, which often contrasts with institutions whose primary duty is to shareholders.Redefining Wealth: Derived from historical roots meaning “well-being” and “health,” true wealth expands beyond finances to include emotional, spiritual, intellectual, physical, and community well-being.The Human Reality of Inherited & Sudden WealthThe “tsunami effect” of sudden financial responsibility often occurs without emotional or practical preparation.Paradox of Self-Worth: Entrepreneurs may connect identity to productivity, while inheritors may experience declining self-worth as net worth increases.The “Luxury of Doing Nothing” Dilemma: Without survival-driven motivation, inheritors must intentionally create purpose, challenge, and structure.Wealth as an Amplifier: Money magnifies existing traits — generosity, anxiety, creativity, or avoidance.Legacy, Family Dynamics & Proactive PlanningFair vs. Equal: Families frequently confuse equality with fairness — and the distinction matters.The biggest estate-planning risk is surprise; open, multi-generational dialogue reduces conflict and shock.Purpose-Driven Philanthropy: Giving should reflect authentic values — not obligation or performance.Their approach integrates both technical financial strategy and coaching-informed human insight.Programs, Resources & MentionsThe Way Into Wealth Program — An eight-session, one-on-one coaching experience aligning inner values with financial reality.Visit: wayintowealth.comThe Wealth Conservancy — A retainer-based fiduciary advisory firm specializing in complex wealth strategy and stewardship.Visit: thewealthconservancy.com | twwcinc.orgThe Family Room Wellness AssociatesOnline Therapy and Coaching with Jason Wasser, LMFTCheck out our guests books!Want to learn more from our guests and also see what products I suggest?Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show

In this episode we answer emails from Tyler, Michael and Jon.  We discuss managing an inherited Roth across a 10-year window and related questions, compare VXUS to targeted international tilts, tax and asset location considerations for traditional and Roth IRAs, and talk about some of the basic ideas for achieving higher safe withdrawal rates.And THEN we our go through our weekly portfolio reviews of the eight sample portfolios you can find at Portfolios | Risk Parity Radio.Additional Links:Father McKenna Center Donation Page:  Donate - Father McKenna CenterGolden Ratio Portfolio Article:  Beautiful Constants and the Golden Ratio Portfolio – Portfolio ChartsAfford Anything Podcast #618:  They Ran Out of Money. I Didn't. Here's Why.Slide Deck:  Afford Anything Episode 618 RPR Basics Slide Deck.pdf - Google DriveVideo Summary:  Afford Anything Episode 618 Video Summary.mp4 - Google DriveAfford Anything Risk Parity Portfolio Blueprint:  Afford Anything frank-vasquez-risk-parity-portfolio-BluePrint.pdf - Google DriveBigger Pockets Money Podcast:  The Secret to a 5% Safe Withdrawal Rate | Frank VasquezSlide Deck:  BP Money Interview Slide Deck.pdf - Google DriveVideo Summary:  BP Money 5 Pct Withdrawals (F. Vasquez).mp4 - Google DriveBreathless Unedited AI-Bot Summary:A surprise inheritance, a strict 10-year clock, and a plan that has to work through whatever the market throws at it—this conversation tackles the decisions that actually move the needle. We break down a practical approach to managing an inherited Roth IRA, why delaying withdrawals can preserve tax-free growth, and how to separate speculation from your core allocation so one risky bet doesn't hijack your entire plan. Along the way, we show how risk parity portfolios lower sequence-of-returns risk and why the best “edge” is often calm structure, not prediction.We dig into tax location with real-world transitions in mind. During your working years, most of the portfolio belongs in equities; the puzzle appears when you move toward retirement and spread assets across bonds and diversifiers. That's where location shines: place ordinary-income-heavy assets in traditional accounts, keep the highest-growth assets in Roth, and avoid turning your taxable account into a tax drag. We also talk about securities-backed lines of credit and why reducing portfolio volatility can materially lower margin stress when you're funding future purchases like rentals.If international stocks feel like a copy of your U.S. exposure, they probably are. We explain how currency drives much of the U.S. vs ex-U.S. gap and why targeted tilts—international large cap growth and small cap value—can be a more effective pairing than broad VXUS. Then we tackle illiquid plays and limited partnerships: categorize by the underlying asset, respect rebalancing limits, and treat truly illiquid positions as separate businesses with independent cash flows.Support the show

0:00 Intro 0:04 Spiked yard 3:00 Playing favorites 6:47 Inherited business 8:34 Embarrassed Learn more about your ad choices. Visit megaphone.fm/adchoices

Within three years, this high school teacher bought eight rental units, giving him an extra $1,600/month in pure cash flow and helping him pay for his child's future. Through a combination of affordable markets, “reverse BRRRRs,” and beginner-friendly renovations, Ben Vidovich has built financial freedom that middle-class America rarely achieves.  With his first child on the way, Ben knew he needed something more than the retirement account he was throwing his money into. As a high school teacher living in one of America's most expensive markets, buying a rental property nearby was far from possible, and Ben wasn't sitting on piles of cash.  So, Ben hunted down “affordable” markets across America, took the leap, and bought his first rental property, a duplex, for under $200,000. Three years later, he's perfected the reverse BRRRR strategy to scale quickly, using local banks to fund renovations and rehabs on multiple homes, all from thousands of miles away. Now, he's starting to buy these houses in cash for better passive income and the ability to leverage them to buy even more rentals.  This is a repeatable, middle-class investing strategy anyone can follow, and Ben is actively using it in 2025!  In This Episode We Cover How to invest in real estate on a middle-class salary (while living in a pricey market) The “reverse BRRRR” strategy that you can use to put $0 down on renovated rentals  Inherited tenants: worth it for the instant cash flow or problem for your portfolio? Beginner-friendly renovations that rookie investors can perform from out of state Is it worth it to buy rental properties in cash? How Ben uses paid-off properties as leverage to scale faster  And So Much More! Check out more resources from this show on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BiggerPockets.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.biggerpockets.com/blog/real-estate-1213 Interested in learning more about today's sponsors or becoming a BiggerPockets partner yourself? Email ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠advertise@biggerpockets.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this edition of Ask KT & Suze Anything, Suze answers your questions about borrowing against an insurance policy, medicare, is an expensive car really worth it and so much more! Watch Suze’s YouTube Channel Jumpstart financial wellness for your employees: https://bit.ly/SecureSave Protect your financial future with the Must Have Docs: https://bit.ly/3Vq1V3GGet your savings going with Alliant Credit Union: https://bit.ly/3rg0YioGet Suze’s special offers for podcast listeners at suzeorman.com/offerJoin Suze’s Women & Money Community for FREE and ASK SUZE your questions which may just end up on the podcast. Download the app by following one of these links: CLICK HERE FOR APPLE: https://apple.co/2KcAHbHCLICK HERE FOR GOOGLE PLAY: https://bit.ly/3curfMISee omnystudio.com/listener for privacy information.