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Pancreatic cancer is among the most deadly forms of cancer, and it can be difficult to catch early. But there's some good news: Clinical trials of a new drug called daraxonrasib found that it doubled the survival time of patients with advanced pancreatic cancer. And some oncologists are calling it a game changer—not just for pancreatic cancer, but potentially other forms of cancer too. Ira talks with oncologist Zev Wainberg, who led a clinical trial for the drug. Plus, ALS is a degenerative disease that causes patients to lose their ability to walk, swallow and eventually to breathe. Now, there's a drug for a rare genetic form of ALS that can slow the progression or even reverse some of these symptoms. Ira talks with New York Times health and science reporter Pam Belluck about this new treatment. Guests: Dr. Zev Wainberg is a co-director of UCLA Health's GI Oncology Program. Pam Belluck is a health and science reporter for The New York Times. Other episodes you may enjoy: mRNA Vaccine For Pancreatic Cancer Continues To Show Promise How do clinical trials work, and who can participate? Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Colombia's Presidential Shift Toward Security and Law and Order. Guest: Evan Ellis. Abelardo de la Espriellaappears to have won the Colombian presidency, promising a crackdown on insecurity and organized crime modeled after El Salvador's policies. His victory signals a likely return to strong security cooperation with the United States and a departure from the policies of Gustavo Petro. 91900 MEXICO
Grieving Out Loud: A Mother Coping with Loss in the Opioid Epidemic
As a veteran of the music and entertainment industry, David Nathan has helped shape the careers of A-list artists including Taylor Swift, Amy Winehouse and Ariana Grande.But behind that success, he faced a loss he never could have imagined. His son took what he believed was a Percocet, unaware it was laced with fentanyl, and died at just 19.Now, Nathan is focused on his most personal work yet: helping others navigate mental health challenges in his son's honor.What makes that mission even more meaningful is that it began with his son. Before his death, he founded an apparel company called Happy Jack, donating a portion of proceeds to support children facing mental health struggles.In this episode of Grieving Out Loud, Nathan shares his son's story, what he hopes other parents can learn, and how he's carrying forward a mission rooted in love, loss and purpose.Visit the Happy Jack website. Watch The Risks are Real live assembly here.Related episodes: Promising young entrepreneur dies after taking counterfeit PercocetThe Voice You Knew — The Story You Didn'tWhen Men Don't Cry: Confronting the Culture of Silent GriefSend us Fan MailBehind every number is a story of a life cut short, a family shattered, and a community devastated.They were...daughterssonsmothersfathersfriendswiveshusbandscousinsboyfriendsgirlfriends.They were More Than Just A Number. Support the showConnect with AngelaFollow Grieving Out LoudFollow Emily's HopeRead Angela's BlogSubscribe to Grieving Out Loud/Emily's Hope UpdatesSuggest a GuestFor more episodes and information, just go to our website, emilyshope.charityWishing you faith, hope and courage!Podcast producers:Casey Wonnenberg King & Kayli Fitz
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/gender-studies
Worship with us live online at ExploreGracePoint.com/church-onlineGracePoint Church2351 Rice Creek RdNew Brighton, MN 55112
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/lgbtq-studies
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/politics-and-polemics
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/book-of-the-day
In Real Men on Top: How Patriarchy Shapes Our Reality (Oxford University Press, 2026), Robin Dembroff shows us that we don't just live in a patriarchal world. We live in a world that patriarchy taught us to see. Patriarchy is not simply a system where men dominate women, Dembroff argues. It is a deeper reality-shaping force that legitimizes economic exploitation, political injustice, and social cruelty by dividing all of us into the rigid categories of Man, Woman, Animal, and Child. These categories are presented as natural truths, but Dembroff reveals them as man-made myths--ones that construct a reality in which being characterized as Woman, Animal, or Child marks moral degradation. By no coincidence, feminization, dehumanization, and infantilization are the very degradations used to make a man 'less of a man'. But this book is more than critique; it's also a guide to transformation especially for those grappling with what it means to be a man under patriarchy. Patriarchy's myths celebrate the identity Man, but these myths are no friend to most men. Promising strength and superiority, they instead fuel isolation, emotional repression, and relentless pressure to prove oneself while propping up systems that enrich the powerful few. Rather than deliver freedom and prosperity, these myths entrap and impoverish. Real Men on Top invites readers to see through them and, in so doing, to find new possibilities for living, relating, and becoming human. Sharp, daring, and deeply felt, Real Men on Top is a book for anyone who senses that something is deeply wrong with the way we live and wants to understand how we got here, and where we might begin the work of remaking reality. Robin Dembroff is an Associate Professor of Philosophy at Yale University Caleb Zakarin is CEO and Publisher of the New Books Network.
Texas standout Brooks Bahr joins the program after a highly‑touted prep career and a church mission. Mitch Harper dives into how he’s feeling physically and mentally as he returns to basketball and looks to make an impact in his first season at BYU.
Molecular hydrogen improves your body's antioxidant defenses instead of directly lowering oxidative stress, helping you recover without blocking muscle adaptation Molecular hydrogen helps you maintain speed and power during repeated sprints, especially in the final, fatigue-heavy stages where performance normally declines Hydrogen supports your cellular energy systems by improving mitochondrial function, allowing your muscles to maintain power under stress Unlike traditional antioxidants, hydrogen targets only the most damaging molecules, preserving the signals your body relies on to build strength and endurance Using hydrogen in short, repeated doses, especially through hydrogen-rich water, strengthens your body's resilience and speeds recovery over time
Matt Williamson, former NFL scout and nationally renowned analyst, breaks down the Pittsburgh Steelers like no one else. Don't miss his insight, every Monday-Friday morning. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Promising oral treatment moves closer for Stargardt patients.
Rattling the Bars host Mansa Musa, former political prisoner and Black Panther, speaks with Alberto Toscano, professor of critical theory and author of Late Fascism, about how consent and coercion operate within US civil society and abroad today. In Part 2 of their two-part conversation, Musa and Toscano unpack the history and relevance of Antonio Gramsci, the Italian Marxist theorist imprisoned by fascist dictator Benito Mussolini in 1926, and they discuss how Donald Trump's domestic and foreign platforms in 2026 animate white nationalism—relying on the explicit promise of state violence against targeted populations. Guests:Alberto Toscano is a renowned Italian cultural critic, social theorist, philosopher, translator, and adjunct professor at the Simon Fraser University School of Communication. Toscano is a columnist at In These Times and the (co-)author of numerous books, including: Late Fascism: Race, Capitalism and the Politics of Crisis; and Fanaticism: On the Uses of an Idea.Credits:Producer / Videographer / Editor: Cameron GranadinoBecome a supporter of this podcast: https://www.spreaker.com/podcast/rattling-the-bars--4799829/support.Follow Rattling the Bars on Spotify or Apple Podcasts Sign up for our newsletterFollow us on:Bluesky: @therealnews.comFacebook: The Real News NetworkTwitter: @TheRealNewsYouTube: @therealnewsInstagram: @therealnewsnetworkHelp us continue producing Rattling the Bars by following us and becoming a monthly sustainer
The final hour of Robby & Rexrode continues with Paul Kuharsky of paulkuharsky.com, who brings the latest on the Titans' mandatory mini-camp and the team's performance. Do the Titans have a strong WR core this year? It appears there are five promising WR's who can help contribute to the team. Should the Titans pursue Brendan Sorsby in the NFL supplementary draft?
Promising author, depressing life circumstances for our characters.
The ACT Party's promising to ensure freedom of speech for professional regulators if re-elected. The proposal would ban regulators from disciplining workers for lawful expression outside of professional practice. It would require them to remain neutral on political issues and restrict mandatory training to matters directly related to professional competence and safety. Free Speech Union council member Ani O'Brien told Andrew Dickens these people are currently being judged on more than just their competence. She says workers are being policed on what they post on social media and their political beliefs. LISTEN ABOVE See omnystudio.com/listener for privacy information.
Knicks fan Rich basks in Jalen Brunson leading New York to its first NBA championship since 1973 ESPN's Mike Breen tells Rich what it was like to witness the Knicks-Spurs series courtside from the announcers' chair, what the NBA title win means for the city of New York, past players, and more. Rich and the guys react to Team USA's rout of Paraguay in their World Cup opener and what it could foretell about how far the USMNT's could advance in the knockout rounds. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Worship with us live online at ExploreGracePoint.com/church-onlineGracePoint Church2351 Rice Creek RdNew Brighton, MN 55112
Hour 3 -- Another addition of Danny's Double Dips. The guys also dive into the top young stars in Bay Area Sports, and are later joined by Rich Aurilia to break down the Giants epic comeback capped off by a Bryce Eldridge Grand Slam. See omnystudio.com/listener for privacy information.
Hour 3 -- Another addition of Danny's Double Dips. The guys also dive into the top young stars in Bay Area Sports, and are later joined by Rich Aurilia to break down the Giants epic comeback capped off by a Bryce Eldridge Grand Slam. See omnystudio.com/listener for privacy information.
President Donald Trump has changed a lot about American foreign policy – and to many, America itself. But a lot of the issues facing this country were around long before he became president. Ben Rhodes' new book, All We Say: The Battle for American Identity: A History in 15 Speeches, tells the story of this country through speeches by figures like Ben Franklin, Martin Luther King, and yes, Donald Trump. We spoke with Ben about what those speeches reveal about being American, and what Trump's actions in Iran can tell us about his presidency and our country.And in headlines, President Trump continues to whiplash in Iran talks, we have a new pick for the Director of National Intelligence, and Kash Patel prepares the FBI for the World Cup.Show Notes: Check out Ben's book – https://tinyurl.com/pxpr6t8c Call Congress – 202-224-3121 Subscribe to the What A Day Newsletter – https://tinyurl.com/y4y2e9jy What A Day – YouTube – https://www.youtube.com/@whatadaypodcast Follow us on Instagram – https://www.instagram.com/crookedmedia/ For a transcript of this episode, please visit crooked.com/whataday
Funding novel therapeutics isn't just “harder than ever”—the rules have changed entirely. The wild rush of capital into early-stage biotech during 2020–2021 gave way to a drought, making investor priorities sharper and startup hurdles higher than most founders realize.Michael Rome, Managing Director at Foresite Capital, joined the Smart Biotech Scientist Podcast to dissect what's really driving funding decisions today, and what early-stage founders must do to stand out.Key topics discussed:The financial cycle of biotech investment before, during, and after the COVID-19 boom (02:47)Why investors are now focused on clear pathways to approved drugs and how founders should frame their proposals (06:10)The evolving importance of CMC expertise and manufacturing readiness for startups at different stages (07:44)Leadership traits and execution qualities investors appreciate in biotech founders and teams (09:18)Promising scientific and market areas including small molecule oncology, degraders, and heterobifunctional molecules (11:24)Practical advice for founders preparing for fundraising: focusing on unmet medical needs and market analysis (14:55)The impact of recent M&A activity and regulatory challenges at the FDA on the future of biotech investment (16:27)The importance of open communication and collaboration between scientists and investors (18:47)Smart insight: For those preparing their next fundraising push, Michael advised:Start with the end in mind: Outline the unmet need, the clinical and market pathway, and the product vision firstReverse engineer your innovation: Work backwards from market and regulatory needs to inform your technical approach, not the other way around.Frame your business case: Make it obvious to investors how your solution advances value in the ecosystemIf you want to go deeper into the themes from this conversation with Michael Rome—how investors evaluate biotech companies, why CMC and execution matter, and how founders can better frame their science for funding—these episodes are a strong next listen:Episodes 189 - 190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later)Episodes 165 - 166: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It)Episodes 183 - 184: From Lab to Market: Secrets to Commercializing Cutting-Edge Biotech Innovations with Chervee HoEpisodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannConnect with Michael Rome: LinkedIn: https://www.linkedin.com/in/michael-rome-5067616b/ Foresite Capital website: www.foresitecapital.comNext: If you enjoyed this episode, please leave a review on Apple Podcasts or your favorite podcast platform. By doing so, we can empower more scientists like you. Stay tuned for more inspiring biotech insights in our next episode.Support the show
The Labour Party is promising cost-of-living relief for public transport users - pledging to cap their fares at no more than $20 a week if elected. National says it's just more irresponsible spending from Labour. Deputy political editor Craig McCulloch reports.
Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. The landscape of these industries is one of constant evolution, characterized by scientific advancements, strategic mergers, and regulatory maneuvers that shape the future of healthcare. In a significant scientific breakthrough, Merck & Co. and Gilead Sciences have made strides in HIV treatment with the development of a weekly pill. This innovative regimen combines Merck's islatravir with Gilead's lenacapavir, showing promise in two phase 3 trials. If approved, this long-acting oral therapy could revolutionize HIV care by offering a more convenient dosing schedule, potentially improving patient adherence and outcomes substantially. This novel regimen signifies progress towards simplifying HIV treatments with once-weekly dosing. Meanwhile, in the oncology sector, Gilead's Trodelvy faced challenges when combined with Merck's Keytruda as a first-line treatment for PD-L1-high non-small cell lung cancer. The phase 3 EVOKE-03 trial was terminated, shifting attention to competitors like AstraZeneca and Daiichi Sankyo, who continue to advance their own therapies in this area. In a strategic move to bolster its position in lung cancer treatment, GlaxoSmithKline (GSK) is acquiring Nuvalent for $10.6 billion, aiming to secure near-approval cancer therapies capable of challenging market leaders like Roche and Pfizer. This acquisition underscores the focus on targeted cancer therapies that increase treatment efficacy by honing in on specific genetic markers. Nuvalent's innovative pipeline of small molecule inhibitors targets drug resistance and mutations in cancer treatment—a strategic addition to GSK's portfolio aimed at enhancing its position amidst rapid advancements and intense competition in oncology. In diabetes and obesity management, Eli Lilly is advancing with its new oral GLP-1 receptor agonist, Foundayo (orforglipron), which has shown competitive efficacy over oral semaglutide. Analysts see Lilly's progress as strengthening its leadership in the growing obesity drug market. Similarly, AstraZeneca is making progress with its own GLP-1 candidate, elecoglipron, as phase 2 data sets the stage for pivotal studies. Promising clinical trial data from Eli Lilly's retatrutide for obesity-related conditions and AstraZeneca's elecoglipron suggest a strengthening pipeline for GLP-1 receptor agonists known for their dual effects on weight management and glycemic control. On the diagnostics front, Roche reaffirms its €600 million investment in Germany amid industry retrenchments by companies like Eli Lilly and Boehringer Ingelheim. However, Roche remains cautious about future risks due to shifting economic conditions. The financial dynamics within biotech are also noteworthy. Parabilis Medicines is planning a potentially record-setting IPO following Kailera Therapeutics' successful public offering earlier this year. These trends indicate strong investor confidence and an influx of funding towards innovative cancer therapies. Meanwhile, CeQur's $100 million Series E funding round aims at accelerating insulin patch delivery systems' commercial growth—highlighting ongoing innovation in diabetes management solutions. Regulatory updates reveal AstraZeneca facing reprimands from the UK marketing watchdog due to repeated breaches related to LinkedIn activities—an ongoing challenge in pharmaceutical marketing compliance. The integration of digital health solutions continues apace as ixlayer partners with Vertex Pharmaceuticals to launch a digital acute pain management platform. This initiative aims at improving patient care by reducing reliance on opioid-based treatments. These developments paint a picture of an industry where scientific innovations, regulatory hurdles, and technological advancements intersect to shape future therapeutic landscapes. Precision oncology is another area witnessing substantial growth. The landscape also sees notable activity in rare disease therapeutics. Johnson & Johnson's Talvey has gained acceptance in Scotland for treating relapsed multiple myeloma using bispecific antibody technology—a trend toward leveraging immune system targeting technologies to enhance cancer treatment efficacy. Moreover, Zai Lab's Tivdak received approval from China's NMPA for cervical cancer treatment based on Phase 3 data, highlighting the rise of antibody-drug conjugates (ADCs) as potent oncology therapies due to their targeted delivery mechanisms. On the research collaboration front, AlzeCure Pharma's partnership with Eli Lilly focuses on Alzheimer's disease research through Alzstatin ACD680—a small molecule targeting neurodegenerative pathways—a testament to the collaborative efforts needed to tackle complex diseases like Alzheimer's. However, challenges persist as Bial discontinued its GCase activator program after failing Phase 2b trials for Parkinson's patients with GBA1 variants—a stark reminder of the high-risk nature inherent in drug development despite initial promise. These myriad developments underscore a vibrant period within pharmaceutical and biotech sectors where scientific advancements rapidly translate into actionable therapies promising substantial improvements in patient care by addressing unmet medical needs globally.Support the show
Doubling funding for the QEII National Trust would be the best bang for buck conservation investment the next Government could make, Federated Farmers says. The National Party recently announced it will double the trust's funding if it's part of the next Government. The Country's Jamie Mackay explained further. LISTEN ABOVESee omnystudio.com/listener for privacy information.
There's a sin you keep promising yourself you'll quit — and you're starting to wonder why you can't. This message walks through Revelation 8 and 9, the seven trumpets, and one uncomfortable truth most of us feel but rarely say out loud: sin doesn't stay a choice forever. At some point you stop choosing it, and it starts choosing you.We tend to read Revelation as a map of the end of the world. But the seventh seal doesn't open onto final destruction — it opens onto the Day of Atonement and a trumpet blast that, to the people who first heard it, meant one thing: a call to come home. The trumpets aren't only about the future. They're a warning about right now — about the thing quietly enslaving you, the way it dresses itself up as harmless, and the freedom that's actually possible when you finally name it. This isn't a timeline. It's an invitation.Support the show
Worship with us live online at ExploreGracePoint.com/church-onlineGracePoint Church2351 Rice Creek RdNew Brighton, MN 55112
Why Golf is back!For the first episode of the new series, Di Stewart is catching up with a woman who is hoping to make the Team Europe roster for this autumn's Solheim Cup - Mimi Rhodes.She details the whirlwind journey she's been on since turning pro, and the reality of life on tour when she's travelling the globe.Mimi also reveals that she almost chose tennis over golf, and the joy she finds in playing golf with different generations of her family - something she highlights you can't do in any other sport.Plus, with this year's Solheim Cup on the horizon, Mimi reveals the burning desire she has to be selected, as the all important rankings get closer to being finalised, and European captain Anna Nordqvist makes her crucial captain's picks.Find more Why Golf content on Instagram, and find out more about everything the Why Golf platform has to offer
We're learning from court transcripts that investigators tested a second male cruise passenger as a potential match to DNA recovered from Anna Kepner's rape kit. Pennsylvania volunteer firefighter confesses he's behind three weekend fires. Promising college football player shot day after his graduation ceremony. Sydney Silvagni reports. See omnystudio.com/listener for privacy information.
Pres. Trump is transforming politics and American values as an America First agenda takes hold. Or is it? Opposition remains entrenched, leftists are fighting harder to hold the levers of government, foreign policy, economic redistribution and racial inequities. Promising early GOP vote counts in California, or the snatching of victory in a fixed election system? Perspective and commentary on all of Thursday morning's biggest stories
A medical breakthrough in the fight against pancreatic cancer is showing promising results after decades of research. The experimental drug, taken once a day, extends patients' lives by slowing the progression of one of the deadliest cancers. Dr. Rachna Shroff, associate director of clinical investigations at the University of Arizona Comprehensive Cancer Center, joins Stephanie Sy for more. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy
Worship with us live online at ExploreGracePoint.com/church-onlineGracePoint Church2351 Rice Creek RdNew Brighton, MN 55112
AbstractThis article explores the often-overlooked tragedy of promising happiness through overcoming disability. It draws on qualitative interviews and focus groups with 36 adults with cerebral palsy to explore how medical discourse shapes the ways in which individuals are encouraged to pursue a good life, leading to unintended consequences. Sara Ahmed's theory of happiness is used to understand the dialectics of pursuing a good life through overcoming disability, revealing how medical interventions and discourse during childhood inadvertently contribute to feelings of inferiority and social alienation. The article highlights the need to reconsider how individuals with disabilities are encouraged to pursue a good life, emphasizing the paradox of disabling effects arising from attempts to minimize and overcome disability.https://www.sciencedirect.com/science/article/pii/S027795362500098X
Probiotics: A Promising Adjunct to Non-surgical Periodontal Therapy?By Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/probiotics-a-promising-adjunct-to-non-surgical-periodontal-therapy/Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
In this segment, Mark is joined by Jacob Olidort, a Chief Research Officer and Director of American Security at the America First Policy Institute. They discuss the latest in what President Trump is calling "very promising talks" with Iran.
Only one in three eligible lung cancer patients receives the targeted therapy they should get.That is not a failure of science.It is a failure of delivery.After more than two decades of precision oncology, biopharma has never had better tools: cell and gene therapy, in vivo CAR-T, antibody-drug conjugates, AI-enabled diagnostics, organoids, multi-omics, and global clinical data.Yet too many breakthroughs still fail to reach the bedside.Patients fall through fragmented systems.Data does not move cleanly.Community oncologists are overloaded.Tests are missed, delayed, or misread.Promising assets die in quarterly portfolio reviews.And healthcare systems built for pills, tablets, and chronic disease management are now being asked to deliver personalized medicine at scale.In this SPARK20 highlight episode, Alasdair Milton, PhD, Principal at KPMG and leader of the firm's Precision & Advanced Therapies practice, explains why the future of biopharma will not be decided by science alone.It will be decided by translation.From lab bench to boardroom.From data to decisions.From treatment to prevention.Alasdair brings more than 20 years of experience across life sciences strategy, commercial due diligence, precision medicine, advanced therapies, cell and gene therapy, biopharma M&A, diagnostics, and global healthcare transformation.This conversation moves from the precision medicine delivery crisis to China's biotech acceleration, from AI and organoids to trapped pharma assets, from lifelong wellness to the one skill every future biotech leader needs:The ability to translate complex science into business strategy, capital allocation, and patient impact.What You'll Learn in 22 MinutesWhy only one third of eligible lung cancer patients receive targeted therapy(00:01:53)And why precision medicine still breaks in everyday clinical practice.Why science keeps compounding even when systems fail(00:04:33)Including in vivo CAR-T, functional cures, gene therapy, and antibody-drug conjugates.Why innovation does not move in a straight line(00:05:20)How technologies can look dead for years before suddenly changing the market.Why China's biotech speed matters(00:07:36)How AI, organoids, scale, and execution are changing the global innovation map.Why great science dies inside Big Pharma(00:09:20)And how deprioritized assets can become billion-dollar companies when externalized properly.Why the industry must move from sickness to lifelong wellness(00:10:03)Alasdair's vision for a more proactive, preventive, data-driven healthcare system.Why pharma needs better ways to rescue shelved assets(00:13:06)Including examples such as SpringWorks, Cerevel, and new models for unlocking trapped value.How a 400-person Scottish island shaped Alasdair's worldview(00:15:07)The personal story behind his resilience, discipline, and leadership style.Why careers and companies are never linear(00:17:19)What Alasdair learned after moving to Boston and losing his role within weeks.Why the future belongs to translators(00:20:06)The most valuable skill in biotech: explaining complex science to business leaders, investors, and boards.How to connect with Alasdair Milton and the KPMG Precision & Advanced Therapies team(00:21:47)Quotes to Carry With You
In this episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with survivor Jenaé Newell and director Ben Zand about their riveting new docuseries, The Cult of Natureboy. "The Cult of NatureBoy" is a new docuseries examining the dark reality behind online spiritual leader Eligio "NatureBoy" Bishop and his community, Carbon Nation. Promising a liberated "black utopia" through raw living, Bishop lured followers into a manipulative, abusive, and violent sex cult that ended with his life imprisonment. This episode was previously published on Missing on May 21st, 2026. Check out it: https://www.hulu.com/series/ce23eaed-d60d-472f-aa32-294619e7f438. Follow Jenaé Newell: https://www.instagram.com/jenae.alexandrea. Check out Jenaé Newell's book: https://www.amazon.com/Lesson-Learned-Wisdom-Granted-Divine/dp/B0CVF35Q12. Zandland: https://www.zand.land/. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with survivor Jenaé Newell and director Ben Zand about their riveting new docuseries, The Cult of Natureboy. "The Cult of NatureBoy" is a new docuseries examining the dark reality behind online spiritual leader Eligio "NatureBoy" Bishop and his community, Carbon Nation. Promising a liberated "black utopia" through raw living, Bishop lured followers into a manipulative, abusive, and violent sex cult that ended with his life imprisonment. Check out it: https://www.hulu.com/series/ce23eaed-d60d-472f-aa32-294619e7f438. Follow Jenaé Newell: https://www.instagram.com/jenae.alexandrea. Check out Jenaé Newell's book: https://www.amazon.com/Lesson-Learned-Wisdom-Granted-Divine/dp/B0CVF35Q12. Zandland: https://www.zand.land/. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Britt Robson of MinnPost joins Korzo to talk about what Wolves fans can hope for this offseason before conversations about Harvard toughening up their grading policies, Pizza Hut locations going retro, and some sports topics during the Shot Clock!
This interview is disseminated on behalf of Medicus Pharma Ltd.In this episode of Stocks to Watch, we are joined by Medicus Pharma (NASDAQ: MDCX) Executive Chairman and CEO Dr. Raza Bokhari to discuss the company's promising Phase 2 results for SkinJect, its innovative skin cancer treatment, and what lies ahead for the company across oncology, rare diseases, and prostate cancer.Learn more about Medicus Pharma: https://medicuspharma.com/Watch the full YouTube interview here: https://youtu.be/4GZIBnS2KZ0And follow us to stay updated: https://www.youtube.com/GlobalOneMedia
One year on from when Pope Leo became head of the Catholic church and he remains a bit of an enigma. Is he a Conservative or Liberal? What did we learn from his clash with Donald Trump? Damian Thompson is joined by editor of The Pillar Ed Condon and two Spectator favourites – Freddy Gray and Mary Wakefield. Hosted on Acast. See acast.com/privacy for more information.
Dr. Brad Stanfield, a primary care physician from New Zealand and friend of this channel, did something heroic. He crowdfunded over $720,000 to put the “miracle drug” to the test. The results are finally in, and they aren't what anyone expected. I brought @DrBradStanfield onto the show to talk about what they mean. Get Early Access on Substackhttps://sgcarney.substack.com/Join this channel to get access to perks:https://www.youtube.com/channel/UC3PyxGKt94kLzVqkkjEgRFw/join
One year on from when Pope Leo became head of the Catholic church and he remains a bit of an enigma. Is he a Conservative or Liberal? What did we learn from his clash with Donald Trump? Damian Thompson is joined by editor of The Pillar Ed Condon and two Spectator favourites – Freddy Gray and Mary Wakefield. Become a Spectator subscriber today to access this podcast without adverts. Go to spectator.co.uk/adfree to find out more.For more Spectator podcasts, go to spectator.co.uk/podcasts. Contact us: podcast@spectator.co.uk Hosted on Acast. See acast.com/privacy for more information.
Wednesday, May 6. The seven stories you need to know today.Read today's briefing.
See omnystudio.com/listener for privacy information.
Iran negotiations appear on the verge of collapse as the ceasefire deadline approaches, with U.S. officials preparing to travel for talks even as Iranian leadership signals it may not participate. Outrage is mounting after the IDF confirmed a soldier was responsible for smashing a statue of Jesus in southern Lebanon, prompting condemnation from Prime Minister Netanyahu and Christian leaders. FBI Director Kash Patel files a $250 million defamation lawsuit against The Atlantic, accusing the outlet of knowingly publishing false allegations about his conduct based on anonymous sources. A personalized mRNA vaccine for pancreatic cancer is showing early signs of promise in a small Phase 1 trial. California's governor's race is shifting following Eric Swalwell's exit amid scandal, with new polling showing former HHS Secretary Xavier Becerra gaining ground as a potential contender. Birch Gold: Text MK to 989898 to join Birch Gold's Learn and Earn event by April 30! Supersure Insurance: Simplify your business insurance and get a free coverage report at https://Supersure.com/Megyn Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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