Podcasts about Gilead

Play Episode Listen Later Jun 11, 2026 21:47

This episode covers: Cardiology This Week: A concise summary of recent studies Transcatheter treatment of tricuspid regurgitation Carcinoid heart disease Milestones: MADIT-II Trial Host: Wilfried Mullens Guests: Stephan Baldus, Heidi Connolly and Konstantinos Koskinas Want to watch that episode? Go to: https://esc365.escardio.org/event/2560 Want to watch that extended interview on transcatheter treatment of tricuspid regurgitation, go to: https://esc365.escardio.org/event/2560?resource=interview Disclaimer ESC TV Today is supported by Novartis and Novo Nordisk through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Heidi Connolly, Nicolle Kraenkel and Wilfried Mullens have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Novo Nordisk, Pfizer, Sanofi, Servier, Takeda, Tecnimede, Viatris. Stephan Baldus has declared to have potential conflicts of interest to report: research grant from Abbott, lecture fees from Abbott and Edwards. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

canada ai english treatments consulting edwards pfizer calgary esc statements abbott astrazeneca bayer philips heart disease merck johnson johnson gilead ferrer novartis declarations novo nordisk sanofi medtronic gsk amgen zoll abbvie bristol myers squibb takeda european society msd boehringer ingelheim deutsche gesellschaft inari regurgitation bial daiichi sankyo edwards lifesciences servier transcatheter bristol myers viatris alnylam sanofi aventis tricuspid carcinoid cardiology esc biotronik

Season 4 - Ep.11: Extended interview on transcatheter treatment of tricuspid regurgitation

Combinate Podcast - Med Device and Pharma

Play Episode Listen Later Jun 11, 2026 11:34

Host: Wilfried Mullens Guest: Stephan Baldus Want to watch that extended interview, go to: https://esc365.escardio.org/event/2560?resource=interview Want to watch that entire episode? Go to: https://esc365.escardio.org/event/2560 Disclaimer ESC TV Today is supported by Novartis and Novo Nordisk through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Nicolle Kraenkel and Wilfried Mullens have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Novo Nordisk, Pfizer, Sanofi, Servier, Takeda, Tecnimede, Viatris. Stephan Baldus has declared to have potential conflicts of interest to report: research grant from Abbott, lecture fees from Abbott and Edwards. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

241 - ICH Q14 Explained: Have We Been Validating Methods Backwards?

Play Episode Listen Later Jun 10, 2026 10:29

In this final episode of the ICH Quality series, we walk through the most important concepts in ICH Q14 and how they fit into the broader ICH quality framework.Rather than reviewing the guideline section by section, this episode focuses on the ideas that are most useful in practice: Why does ICH Q14 start with the Analytical Target Profile (ATP)? How is it different from ICH Q2? How do you develop analytical procedures using a science- and risk-based approach? And what does all of this have to do with ICH Q12 and lifecycle management?One quick note: at the time of recording, ICH Q14 remains under public comment, so some details may evolve before the final version is adopted.Chapters00:00 – Intro and ICH Q14 vs. Q201:08 – The Analytical Target Profile (ATP)04:16 – The Analytical Procedure Lifecycle05:32 – Risk-Based Development and Enhanced Approaches06:20 – Where ICH Q2 Fits: Validation08:04 – Connecting Q14 to ICH Q12 and Lifecycle Management09:22 – Closing the ICH Quality SeriesIn this episode, we cover:• Why ICH Q14 exists• The difference between ICH Q14 and ICH Q2• What an Analytical Target Profile (ATP) is• ATP examples and performance criteria• Technology selection and fit-for-purpose methods• The analytical procedure lifecycle• Risk assessments and enhanced development approaches• Multivariate experiments and DOE concepts• Analytical procedure control strategies• Validation and the role of ICH Q2• Lifecycle management of analytical procedures• The connection between ICH Q14 and ICH Q12• Why understanding matters more than simply checking a boxIf you've followed along through the ICH Quality series, one of the themes that keeps showing up is that quality isn't something you test into products at the end. Whether we're talking about Q8, Q9, Q10, Q12, or now Q14, the emphasis continues to shift toward building knowledge, understanding risk, and using that understanding throughout the lifecycle.Subhi Saadeh is the Founder and Principal at Let's Combinate, where he helps teams develop and control drug-device combination products by aligning quality systems, development, and regulatory expectations across drug and device domains. He is a consultant, auditor, trainer, speaker, and host of the Let's Combinate podcast, with experience across companies including Pfizer, Gilead, and Baxter supporting vaccines, biologics, generics, and combination products.

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CME/CE Podcast - Integrating TROP2-Directed ADCs into TNBC Treatment Plans: Novel Aspects of Efficacy and Safety Profiles

The NACE Clinical Highlights Show

Play Episode Listen Later Jun 10, 2026 27:05

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit:https://www.mycme.com/courses/the-evolving-role-of-antibody-drug-conjugates-in-metastatic-triple-negative-breast-cancer-10800SummaryThis CME/CE-certified podcast will provide multidisciplinary clinicians with an evidence-based update on the evolving role of TROP2-directed antibody-drug conjugates (ADCs) in the frontline treatment of metastatic triple-negative breast cancer. A medical and an ocular oncology specialist review the latest efficacy and safety data from pivotal clinical trials evaluating ADCs, their integration into contemporary treatment algorithms, and guideline recommendations based on PD-L1 status, BRCA mutation status, and immunotherapy eligibility. Learners will explore key factors influencing treatment selection, compare the benefits and limitations of more established therapeutic options, and examine practical strategies for preventing, recognizing, and managing ADC-associated toxicities. Special emphasis will be placed on multidisciplinary approaches to the management of ocular adverse events and other clinically significant toxicities to optimize patient outcomes and support safe implementation of these therapies in clinical practice.Learning ObjectivesEvaluate the current and emerging clinical evidence surrounding the use of trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugates (ADCs) in the first-line treatment of metastatic triple-negative breast cancer (TNBC)Integrate TROP2-directed ADCs into frontline treatment regimens for metastatic TNBC based on the latest clinical evidence, guidelines, and patient- and tumor-specific factorsApply multidisciplinary and patient-centric strategies for the prevention, recognition, and management of toxicities associated with the use of TROP2-directed ADCs in patients with metastatic TNBCThis activity is accredited for CME/CE CreditThe National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The National Association for Continuing Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.The National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.50 contact hours (which includes 0.50 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com.Faculty and Moderator Aditya Bardia, MDProgram Director, Breast Medical Oncology, UCLAProfessor of Medicine, UCLALos Angeles, CADr. Bardia has disclosed the following financial relationships:Consultant: Alyssum, AstraZeneca/Daiichi, BMS, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, VyomeAdvisor/Advisory Board: Alyssum, AstraZeneca/Daiichi, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, VyomeContracted Research: AstraZeneca/Daiichi, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, PfizerStock options: Vyome (immuno-inflammatory and rare diseases)All of his consultant, advisor/advisory board, and contracted research disclosures are related to cancer.Maura Di Nicola, MDAssistant Professor of OphthalmologyBascom Palmer Eye InstituteMedical Director of Imaging and EchographyBascom Palmer Eye InstituteMiami, FLDr. Di Nicola has disclosed the following financial relationships:Consultant: AbbVie (ophthalmology), SpringWorks Therapeutics (oncology)Advisor/Advisory Board: AbbVie (ophthalmology)Research Grant: Castle Biosciences (ocular oncology)Please review additional planner disclosures here.Disclosure of Commercial SupportThis educational activity is supported by a medical education grant from AstraZeneca Pharmaceuticals and a medical education grant from Daiichi Sankyo, Inc.Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

medicine safety treatments physicians pfizer national association directed faculty integrating provider disclosure aspects american association credits profiles imaging merck learners nurse practitioners efficacy nace gilead continuing education novartis eli lilly genentech brca adc bms ce podcast adcs pd l1 accreditation council tnbc bardia daiichi sankyo ama pra category cme/ce continuing medical education accme breast medical oncology menarini

Merck & Gilead's HIV Pill Breakthrough: Phase 3 Success! | Pharma and Biotech Daily

Central Church Contemporary Service

Play Episode Listen Later Jun 10, 2026 5:23

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. The landscape of these industries is one of constant evolution, characterized by scientific advancements, strategic mergers, and regulatory maneuvers that shape the future of healthcare. In a significant scientific breakthrough, Merck & Co. and Gilead Sciences have made strides in HIV treatment with the development of a weekly pill. This innovative regimen combines Merck's islatravir with Gilead's lenacapavir, showing promise in two phase 3 trials. If approved, this long-acting oral therapy could revolutionize HIV care by offering a more convenient dosing schedule, potentially improving patient adherence and outcomes substantially. This novel regimen signifies progress towards simplifying HIV treatments with once-weekly dosing. Meanwhile, in the oncology sector, Gilead's Trodelvy faced challenges when combined with Merck's Keytruda as a first-line treatment for PD-L1-high non-small cell lung cancer. The phase 3 EVOKE-03 trial was terminated, shifting attention to competitors like AstraZeneca and Daiichi Sankyo, who continue to advance their own therapies in this area. In a strategic move to bolster its position in lung cancer treatment, GlaxoSmithKline (GSK) is acquiring Nuvalent for $10.6 billion, aiming to secure near-approval cancer therapies capable of challenging market leaders like Roche and Pfizer. This acquisition underscores the focus on targeted cancer therapies that increase treatment efficacy by honing in on specific genetic markers. Nuvalent's innovative pipeline of small molecule inhibitors targets drug resistance and mutations in cancer treatment—a strategic addition to GSK's portfolio aimed at enhancing its position amidst rapid advancements and intense competition in oncology. In diabetes and obesity management, Eli Lilly is advancing with its new oral GLP-1 receptor agonist, Foundayo (orforglipron), which has shown competitive efficacy over oral semaglutide. Analysts see Lilly's progress as strengthening its leadership in the growing obesity drug market. Similarly, AstraZeneca is making progress with its own GLP-1 candidate, elecoglipron, as phase 2 data sets the stage for pivotal studies. Promising clinical trial data from Eli Lilly's retatrutide for obesity-related conditions and AstraZeneca's elecoglipron suggest a strengthening pipeline for GLP-1 receptor agonists known for their dual effects on weight management and glycemic control. On the diagnostics front, Roche reaffirms its €600 million investment in Germany amid industry retrenchments by companies like Eli Lilly and Boehringer Ingelheim. However, Roche remains cautious about future risks due to shifting economic conditions. The financial dynamics within biotech are also noteworthy. Parabilis Medicines is planning a potentially record-setting IPO following Kailera Therapeutics' successful public offering earlier this year. These trends indicate strong investor confidence and an influx of funding towards innovative cancer therapies. Meanwhile, CeQur's $100 million Series E funding round aims at accelerating insulin patch delivery systems' commercial growth—highlighting ongoing innovation in diabetes management solutions. Regulatory updates reveal AstraZeneca facing reprimands from the UK marketing watchdog due to repeated breaches related to LinkedIn activities—an ongoing challenge in pharmaceutical marketing compliance. The integration of digital health solutions continues apace as ixlayer partners with Vertex Pharmaceuticals to launch a digital acute pain management platform. This initiative aims at improving patient care by reducing reliance on opioid-based treatments. These developments paint a picture of an industry where scientific innovations, regulatory hurdles, and technological advancements intersect to shape future therapeutic landscapes. Precision oncology is another area witnessing substantial growth. The landscape also sees notable activity in rare disease therapeutics. Johnson & Johnson's Talvey has gained acceptance in Scotland for treating relapsed multiple myeloma using bispecific antibody technology—a trend toward leveraging immune system targeting technologies to enhance cancer treatment efficacy. Moreover, Zai Lab's Tivdak received approval from China's NMPA for cervical cancer treatment based on Phase 3 data, highlighting the rise of antibody-drug conjugates (ADCs) as potent oncology therapies due to their targeted delivery mechanisms. On the research collaboration front, AlzeCure Pharma's partnership with Eli Lilly focuses on Alzheimer's disease research through Alzstatin ACD680—a small molecule targeting neurodegenerative pathways—a testament to the collaborative efforts needed to tackle complex diseases like Alzheimer's. However, challenges persist as Bial discontinued its GCase activator program after failing Phase 2b trials for Parkinson's patients with GBA1 variants—a stark reminder of the high-risk nature inherent in drug development despite initial promise. These myriad developments underscore a vibrant period within pharmaceutical and biotech sectors where scientific advancements rapidly translate into actionable therapies promising substantial improvements in patient care by addressing unmet medical needs globally.Support the show

June 7

Play Episode Listen Later Jun 10, 2026 21:10

by Aubrey Botha https://cpcchurchimages.s3.amazonaws.com/wp-content/uploads/2026/06/10121328/June-7-Sermon.mp3 Genesis 37:5-11 (NLT) 5 One night Joseph had a dream, and when he told his brothers about it, they hated him more than ever. 6 “Listen to this dream,” he said. 7 “We were out in the field, tying up bundles of grain. Suddenly my bundle stood up, and your bundles all gathered around and bowed low before mine!” 8 His brothers responded, “So you think you will be our king, do you? Do you actually think you will reign over us?” And they hated him all the more because of his dreams and the way he talked about them. 9 Soon Joseph had another dream, and again he told his brothers about it. “Listen, I have had another dream,” he said. “The sun, moon, and eleven stars bowed low before me!” 10 This time he told the dream to his father as well as to his brothers, but his father scolded him. “What kind of dream is that?” he asked. “Will your mother and I and your brothers actually come and bow to the ground before you?” 11 But while his brothers were jealous of Joseph, his father wondered what the dreams meant. Genesis 37:25-28 25 Then, just as they were sitting down to eat, they looked up and saw a caravan of camels in the distance coming toward them. It was a group of Ishmaelite traders taking a load of gum, balm, and aromatic resin from Gilead down to Egypt. 26 Judah said to his brothers, “What will we gain by killing our brother? We'd have to cover up the crime.[a] 27 Instead of hurting him, let's sell him to those Ishmaelite traders. After all, he is our brother—our own flesh and blood!” And his brothers agreed. 28 So when the Ishmaelites, who were Midianite traders, came by, Joseph's brothers pulled him out of the cistern and sold him to them for twenty pieces[b] of silver. And the traders took him to Egypt. Romans 11:29 (MSG) A Complete Israel 25-29 I want to lay all this out on the table as clearly as I can, friends. This is complicated. It would be easy to misinterpret what's going on and arrogantly assume that you're royalty and they're just rabble, out on their ears for good. But that's not it at all. This hardness on the part of insider Israel toward God is temporary. Its effect is to open things up to all the outsiders so that we end up with a full house. Before it's all over, there will be a complete Israel. As it is written, A champion will stride down from the mountain of Zion; he'll clean house in Jacob.And this is my commitment to my people: removal of their sins. From your point of view as you hear and embrace the good news of the Message, it looks like the Jews are God's enemies. But looked at from the long-range perspective of God's overall purpose, they remain God's oldest friends. God's gifts and God's call are under full warranty—never canceled, never rescinded. Transcript (Transcribed by TurboScribe) Thank you, Praise Team. What a wonderful morning of worship again. I missed you on the piano though. 6:10, not 6:07, 6:10. We really want you to do that. Alexander had a little fun with you this morning, but please go do that. 6:10 in the morning or 6:10 in the evening or afternoon, whatever you want to call it. Take a few moments, 5 minutes, 10 minutes, and pray. Pray for our search team in the work that they are doing, finding the next minister for this church. Pray for the person that God is preparing for this position. But also pray for another team because we’ve been struggling for a long time. We’re looking for someone for our youth, and we just do not have folks that are applying, and it’s not just us. It’s all over that we’re struggling with that. Pray for us too. Pray for folks that feel that call to do that. With God’s grace, I think there might be two people. That’ll be good news for those on the team that we might see apply and that we might be able to sit down and talk to. So 6.10 until we find people, take time. Five minutes is all we’re asking. Be quiet, and that’s all you pray for, nothing else. That’s what you pray for. Lord, as we continue our journey with Joseph, not an easy journey, Lord, because it starts in a home, goes to a pit, ends in slavery, but also in the end, it ends in war, more than that. But as we walk this path, help us, Lord, to see you as Joseph did, to see your hand in every moment, even there in the deepest pit, as we said last week. And every day as we walk, and in these moments, may we see Jesus, and only Jesus. I think you got it right, Alexander. Now I moved it, and now it’s all oblong. It started, the trouble started when Joseph’s mouth started. He walked into breakfast that morning, and he was blabbing about this dream that he had. Read with me. I’m going to do the verses little by little. It’s a little bit of fun. One night, Joseph had a dream, and when he told his brothers about it, they hated him more than ever. Remember I told you verse five last week? Listen to this dream, he said. We were out in the field, tying up bundles of grain, and suddenly my bundle stood up, and your bundles all gathered around and bowed low before mine. I do not know what Joseph was thinking. Was he really thinking that his brothers were going to just slap him on the back and say, baby brother, that’s amazing. We can’t wait to bow down before you. Well, they didn’t. They kicked dirt in his face, and they told him to take a hike. Verse nine, verse eight. His brothers responded, so you think you will be our king, do you? Do you actually think you’ll reign over us? And they hated him all the more because of his dreams and the way he talked about them. Now you’d think he would take a hint, but he didn’t. So he just comes right back, and this time with a dream even more elaborate than the first one, verse nine. Soon Joseph had another dream, and again he told his brothers about it. Listen, I’ve had another dream, he said. The sun, the moon, and eleven stars bowed low before me. This time he told the dream to his father as well as to his brothers, but his father scolded him. What kind of dream is that? He asked, will your mother and I and your brothers actually come and bow to the ground before you? But while his brothers were jealous of Joseph, his father wondered what the dream was. He should have kept those dreams to himself, and I think that’s what he was thinking if you think back to last week’s sermon when he was sitting there right at the bottom of that dark pit, heard the brothers up there laughing and having fun. And then all of a sudden, it’s not just their voices, there are other voices too. So let’s go to verse 25. Then just as they were sitting down to eat, the brothers, they looked up and saw a caravan of camels in the distance coming toward them. It was a group of Ishmaelite traders taking a load of gum, balm, and aromatic resin from Gilead down to Egypt. Judah said to his brothers, what will we gain by killing our brother? We’d have to cover up the crime. Instead of hurting him, let’s sell him to those Ishmaelite traders after all. He’s our brother, our own flesh and blood. And his brothers agreed. So when the Ishmaelites who were Midianite traders came by, Joseph’s brothers pulled him out of the cistern and sold him to them for 20 pieces of silver. And the traders took him to Egypt. Just like that. Brothers pulled him out, took the money, grabbed the garment, left, and Joseph had no choice. He was on his way to Egypt to be a slave. Can I just stop the story there for a second? Because I want to set the scene for you for what this sermon is all about. Not too long ago, Joseph had everything going his way. He was hanging out at home. Brothers had to work. He was the loved son and everything was going to him. He had his own tailor who made his own special garment for him. He had these wonderful lofty dreams. But like the old saying goes, what goes up must come down. And Joseph’s life came down with a crash. Down, down, down. Put down by the brothers, thrown down into a cistern, sold down the river of slavery, led down the road to Egypt. Stripped of everything. His name, his status, his position, everything he had, everything he hoped to have, it all went down the drain. Down to Egypt. And this is what the sermon is all about. Because here’s the thing. Life sometimes can do that. It can get us down. We even have sayings for that. I’m down to my last dollar. Just yesterday, this was not written in the sermon, but it gave me in a moment. As I was driving to Zehrs to pick up something, I saw this young lady come to the place where she always stands at the traffic light. And she had this cardboard and she was writing her cardboard again. And as I came back from Zehrs, she was ready and she stood there and she had a down on there. Down on my luck. Because that’s where she is. She’s down. Down to my last penny. Down on my back. Down and out. All of a sudden life takes us down. Boy, that’s a downer this morning. That’s not where I’m going. It takes us down. Now let’s go back to Joseph. Hold on to that. Joseph. When he arrives in Egypt, he has nothing. It’s all taken away. His family, his home, his country. Everything. He has lost everything. But the one thing he didn’t lose was his belief in God’s plan for his life. Joseph never stopped believing that. Never mind how down he went. Down into the pit. Down with the Ishmaelites. Down to Egypt. Down into the dungeon of the jail there. He never stopped believing in the fact that this was God’s plan for his life and nothing would change that. And he was going to hold on to that plan because he knew. Remember last week, Genesis 50 verse 20. You weaved evil. But God is the amazing weaver and God re-weaved, re-wove those plans. And they became plans not just good for me but good for everyone else. Joseph never stopped believing God’s plan and that God had a destiny for him. And I think sometimes, forgive me when I say this, that we forget that. When we hit those Egypt moments, I think sometimes we forget God has a plan. In my, where are we now, 44 years as a minister, I’ve heard many Joseph stories. I told you one last week. I’ve seen many folks going down to Egypt and I’ve always asked them this one question. So with all of this, what is the one thing that you still have that you cannot lose? What is the one thing you still have that you can’t lose? It can’t be taken away. Difficulties can strip us from so many things. Struggles can overwhelm us. But the one thing that no one and nothing can take away from me is God’s destiny for me. But let me explain that word destiny because we sometimes think of fate. Oh, it’s my fate. It’s my destiny. It’s just gonna, no, no, no, no, no, no, no. God’s destiny for you is a little different. Can I use the Hebrew word because the Hebrew word is way more beautiful. Amira, I don’t know if it’s the same in Arabic. Ye’ut in Hebrew. Ye’ut. It’s a yot and a ayin and a vav and a dalet in Hebrew. Amira would understand that. Ye’ut means purpose. It also means life’s plan. It also means that which God made me to be and that which God wants me to do. One thing nothing can take away from me is God’s destiny for me. Think of Joseph. And here’s the thing that makes it true for each one of us. The reason we can say that to one another is because of this fact of who you are. Kerry, who are you? You’re not just Kerry. You are Kerry, the child of God. That’s what makes you, you. The fact that we are children of God. Because why is that important? When God says I’m his child, all God does is give the best that God has to me in my life. Also when I’m down in the pit. Also when I’m with Ishmaelite traitors. Also when I land in Egypt and I don’t know where I’m going to be. Also when I’m trying to do good and I land in jail. God still says you’re my child. I have a purpose. I have a plan and I will make that plan work for your life because you’re my child. And we’re going to sing that. I specifically asked Kerry. I sent her a text this week and said can we add another song which we didn’t. We’re going to sing that in a little while where we say I’m no longer a slave to fear or a slave to sin. I am a child of God. The words go from my mother’s womb you have chosen me. Love has called my name. Think of that for a second. That’s who you are. Jeremiah wrote that. Even before I was born you knew me. The Psalm 139 says in my mother’s womb when I was being knit together you already knew who I am. From my mother’s womb you’ve called and you’ve woven me. You’ve called me. Your love has called my name. And then it goes one step further. The song says that I’ve been born again into your family. It’s God’s family we’re there to take care of each other in those down moments. We’re there to lift each other up. We’re there to laugh with each other Paul the young when we can sit on the stool of repentance and just love one another and just smile. I’ve been born again into your family. And then those beautiful words your love your blood flows through my veins. That’s who you are. A child of God. God has a purpose and a plan and a destiny for you even sometimes if it feels it’s going down. Don’t believe the tombstone that says you’re just a dash between two dates. You’re far more than that. Don’t fall into into small thinking. This world can take everything away from you. The one thing they cannot take away is the love of the one who has your destiny in his hand. And sometimes on the way to Egypt we forget that. And then we redefine ourselves according to our catastrophes the things that happen in our lives. And I look at myself well I’m the bankrupt businessman. I’m the recovering addict. I’m the divorcee. I’m the one with the scars. No. No that’s not who you are. That’s not what God does in your life. Despite those little setbacks God is the God of the big comeback. Think of Joseph. He was a nothing in a bit. And look what he was. Because God had a plan not just for Joseph and I’m getting ahead of myself but we’ll get there. Not just for Joseph but for his brothers and for his father and for his family. They would all come back to Egypt and they would settle and God would take care of him. Joseph would understand the dreams of Pharaoh and they could help the world who would come and would come by from them when there was no food. That was God’s plan. Although it looked like it was going down, down, down. God knew about that. Don’t put yourself down. Don’t allow the world to play the down game with you. You are God’s child and God is true to his promises. Listen to this beautiful promise from Romans chapter 11. God’s gifts and God’s call are under full warranty. They never cancelled and they are never rescinded. Believe that. That’s for your life. You’re God’s child. God never goes back on his promises. You’re more than anything that this world could ever throw at you. Remember the question and you’ll put that slide on there. I like that big orange slide. The question I always ask, so what do you still have that you cannot? God’s plan for your life never changes because God never changes. Survival in Egypt begins with a yes to God and to God’s plan. And yes, you have something that you cannot lose. Amen. Take a few moments of silent prayer. Thank you. Father, you are good. Even when we’re in the pit and when we’re in the hands of the Ishmaelites and we have no idea, because you know those amazing plans that you have made. It’s tough sometimes. We go through real difficult times and we kind of wonder. But then we see you and we know. Thank you, Lord. Thank you that you have us, our plans, our destiny in your hands. Not fate. We don’t care about that. We care about you. Thank you, Lord. We love you. In Jesus’ name we pray. Amen.

"Sex and Marriage" Gen. 2:15-25; SoS 4:1-7; 1 Cor. 6:9-11, June 7th, 2026

Redeemer Church

Play Episode Listen Later Jun 9, 2026 66:11

Sermon TextGenesis 2:15–25; Song of Solomon 4:1–7; 1 Corinthians 6:9–11 (ESV)The Lord God took the man and put him in the garden of Eden to work it and keep it. And the Lord God commanded the man, saying, You may surely eat of every tree of the garden, but of the tree of the knowledge of good and evil you shall not eat, for in the day that you eat of it you shall surely die.Then the Lord God said, It is not good that the man should be alone; I will make him a helper fit for him. Now out of the ground the Lord God had formed every beast of the field and every bird of the heavens and brought them to the man to see what he would call them. And whatever the man called every living creature, that was its name. The man gave names to all livestock and to the birds of the heavens and to every beast of the field. But for Adam there was not found a helper fit for him.So the Lord God caused a deep sleep to fall upon the man, and while he slept took one of his ribs and closed up its place with flesh. And the rib that the Lord God had taken from the man he made into a woman and brought her to the man. Then the man said,This at last is bone of my bonesand flesh of my flesh;she shall be called Woman,because she was taken out of Man.Therefore a man shall leave his father and his mother and hold fast to his wife, and they shall become one flesh. And the man and his wife were both naked and were not ashamed.Behold, you are beautiful, my love, behold, you are beautiful! Your eyes are doves behind your veil. Your hair is like a flock of goats leaping down the slopes of Gilead. Your teeth are like a flock of shorn ewes that have come up from the washing, all of which bear twins, and not one among them has lost its young. Your lips are like a scarlet thread, and your mouth is lovely. Your cheeks are like halves of a pomegranate behind your veil. Your neck is like the tower of David, built in rows of stone; on it hang a thousand shields, all of them shields of warriors. Your two breasts are like two fawns, twins of a gazelle, that graze among the lilies. Until the day breathes and the shadows flee, I will go away to the mountain of myrrh and the hill of frankincense. You are altogether beautiful, my love; there is no flaw in you.Or do you not know that the unrighteous will not inherit the kingdom of God? Do not be deceived: neither the sexually immoral, nor idolaters, nor adulterers, nor men who practice homosexuality, nor thieves, nor the greedy, nor drunkards, nor revilers, nor swindlers will inherit the kingdom of God. And such were some of you. But you were washed, you were sanctified, you were justified in the name of the Lord Jesus Christ and by the Spirit of our God.Genesis 2:24Therefore a man shall leave his father and his mother and hold fast to his wife, and they shall become one flesh.1 Corinthians 6:15–17Do you not know that your bodies are members of Christ? Shall I then take the members of Christ and make them members of a prostitute? Never! Or do you not know that he who is joined to a prostitute becomes one body with her? For, as it is written, The two will become one flesh. But he who is joined to the Lord becomes one spirit with him.Proverbs 5:18–19Let your fountain be blessed, and rejoice in the wife of your youth, a lovely deer, a graceful doe. Let her breasts fill you at all times with delight; be intoxicated always in her love

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Corazón Pastoral (Hechos 20) - Ruta 66 con José de Segovia

Podcast El pulso de la Vida

Play Episode Listen Later Jun 9, 2026 50:00

Hay mucha confusión en el mundo evangélico sobre lo que significa el ministerio. Por un lado, se le llama así, casi a cualquier cosa. Y por otra se confunde con el trabajo social, la psicoterapia, la educación, o simplemente la administración de la iglesia. Hay un sólo discurso en el libro de los Hechos a un público específicamente crisitano. Los demás mensajes son evangelísticos, bien dirigidos a judíos, gentiles o en defensa legal, sea ante el Sanedrín o las autoridades romanas. Las palabras de Pablo a los ancianos de la iglesia en Efeso son, por lo tanto, un testimonio único del corazón pastoral del apóstol. Tras una introducción a este texto del capítulo de Hechos, seguimos el método apostólico, mostrando primero lo que no es el ministerio pastoral. Hablamos de quienes llama Pablo, "lobos rapaces que no perdonarán al rebaño" (v. 29). El tema de los "abusos pastorales" está de mucha actualidad, pero no es algo nuevo. La película "Philomena" (2013) nos acerca a un caso histórico muy conocido en Irlanda, pero de una forma poco habitual a estos filmes de denuncia. Stephen Frears acude a un actor conocido por sus papeles cómicos, Steve Coogan, para evitar el tono emocionalmente manipulador, habitual de estas historias. Junto a esa gran actriz británica que es Judy Dench, hacemos un viaje casi documental. Escuchamos escenas de la película doblada al castellano, que comenta José de Segovia. En este programa comenzamos en nuestra Ruta un nuevo trayecto en que vamos a dar lugar también a la literatura, junto al cine, para comentar el texto bíblico. La música seguirá teniendo un papel fundamental, pero estará a partir de ahora a cargo de Daniel Panduro, el creador del diseño sonoro y la realización técnica de estos programas. El libro con el que hemos querido comenzar este recorrido que abarca la ficción literaria, es la sorprendente novela "Gilead" (2004). La prestigiosa obra de Marilynne Robinson trata sobre dos pastores protestantes y sus familias en la vida cotidiana de la América rural con una perspectiva histórica, profundamente personal. Es una novela singular, donde las haya. Para mostrar el corazón pastoral que revela esta historia hemos grabado fragmentos del libro, que escuchamos con entrevistas a la autora sobre su fe por el diario británico The Guardian y el presidente de la universidad evangélica de pasado abolicionista, Wheaton College, Philip Ryken, autor de un libro sobre "Pastores en los clásicos" (2011) de la literatura, que presta especial atención a Gilead. Para acabar, comentamos las lecciones que podemos aprender de este texto de Hechos 20.

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Escaping Gilead! - The Testaments Podcast (Episode 110)

Pod Clubhouse

Play Episode Listen Later Jun 8, 2026 101:01

THE TESTAMENTS – “Secateurs” – While Becka faces the consequences of her actions, Agnes and Daisy must decide how far they're willing to go to protect her. (Disney/Steve Wilkie)LUCY HALLIDAY, CHASE INFINITI, ROWAN BLANCHARD Gilead's history is being re-written, and the resistance is wearing school green. In this jam-packed season finale breakdown, Paul and Caroline dive deep into “Secateurs,” an episode that changes the game for every major player. From high-stakes smuggling operations to heartbreaking sacrifices, we analyze a finale that feels less like an ending and more like the birth of an army. THE TESTAMENTS – “Secateurs” – While Becka faces the consequences of her actions, Agnes and Daisy must decide how far they're willing to go to protect her. (Disney/Steve Wilkie)ELISABETH MOSS

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Pfizer & Chai AI Breakthrough: $1.675B Gilead Deal | Pharma and Biotech Daily

Bible in a Year with Jack Graham

Play Episode Listen Later Jun 8, 2026 4:31

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into a series of significant advancements shaping the landscape of our industry. As technology continues to redefine traditional paradigms, the collaboration between Pfizer and Chai Discovery exemplifies this trend. By harnessing artificial intelligence, particularly through custom models like Chai-3, this partnership aims to revolutionize drug discovery. The integration of AI promises not only to accelerate the identification of biologics and antibodies but also to optimize resource allocation in research and development. Such technological integration could pave the way for an enhanced pipeline of innovative treatments, marking a transformative shift in how therapeutic candidates are developed. In the realm of regulatory developments, Lupin's Ranluspec has recently received FDA approval as an interchangeable biosimilar targeting VEGF-A for various retinal conditions. This move underscores the importance of biosimilars in providing cost-effective alternatives to expensive biologics, thereby expanding patient access to essential treatments for conditions like macular degeneration. Additionally, the MHRA's marketing authorization for Aujemflu, an adjuvanted trivalent influenza vaccine for adults aged 50 and over, reflects ongoing efforts to bolster protection against infectious diseases among vulnerable populations. Clinical trial advancements continue to highlight significant progress in therapeutic development. Otsuka Pharmaceuticals' Phase 3 data on Voyxact has shown promising stabilization of kidney function in patients with Immunoglobulin A nephropathy. This protein therapy targets autoimmune pathways, offering new hope for managing this chronic kidney condition. Similarly, Autobahn Therapeutics' Elunetirom has advanced to a pivotal trial following Phase 2 success in treating bipolar depression. This showcases the potential of small molecule therapies targeting thyroid hormone receptors. Meanwhile, Hikma Pharmaceuticals' victory in a landmark patent case regarding skinny labels marks an important development in pharmaceutical intellectual property rights. The unanimous Supreme Court ruling against Amarin supports the legitimacy of using skinny labels to market generic versions of drugs for non-patented indications. This decision could enhance market competition and drive down healthcare costs, setting a precedent for future intellectual property disputes. On the business front, strategic partnerships and mergers continue to shape industry dynamics. Gilead Sciences' acquisition of Ouro Medicines for $1.675 billion strengthens its autoimmune inflammation pipeline. This transaction exemplifies how major deals are reshaping therapeutic portfolios in response to growing demand for treatments targeting rare diseases. Financially, Solix Pharmaceuticals' success in raising $71 million to advance its siRNA pipeline across multiple therapeutic areas demonstrates investor confidence in RNA-based therapeutics as a promising frontier for innovative treatments. Conversely, challenges persist as evidenced by Takeda's $2.5 billion legal provision over an antitrust case related to Amitiza, underscoring ongoing financial risks associated with litigation in the pharmaceutical sector. Corporate restructuring also signals shifts within the industry landscape. Fulcrum Therapeutics' decision to lay off 85% of its workforce following the discontinuation of its sickle cell disease candidate highlights the volatility and high stakes inherent in drug development. Overall, these developments illustrate a dynamic landscape where scientific innovation is propelled by AI-driven approaches and strategic collaborations while regulatory victories and financial maneuvers shape market dynamics. These trends have profound implications for patient care by potentially accelerating the availability of novel therapies and fostering a competitive environment that drives down costs. As we look ahead, stakeholders must navigate these complexities effectively to harness opportunities and address challenges within this rapidly evolving industry landscape. The ability to adapt and capitalize on emerging trends will be crucial as these sectors continue to evolve, ultimately enhancing patient care and advancing therapeutic frontiers globally. Thank you for joining us today on Pharma Daily; stay tuned for more insights into the ever-changing world of pharmaceuticals and biotech.Support the show

Solomon Avenging the Righteous

Play Episode Listen Later Jun 7, 2026 21:32

In this Bible Story, the great reign of David came to a close. Now Solomon rules over Israel with wisdom, mercy, and justice. As his first act as king, Solomon takes care of those who were loyal to his father, and deals justly with those who betrayed him. This story is inspired by 1 Kings 2. Go to BibleinaYear.com and learn the Bible in a Year.Today's Bible verse is 1 Kings 2:45 from the King James Version.Episode 113: As David is dying, he calls in his son Solomon to bless him and speak God's promises over him. David instructs him on what he should do with Joab and Shimei and requests that he show kindness to Barzillai of Gilead. But Adonijah was not done trying for the throne. He made a request of Bathsheba that Solomon rightly discerned as a claim to the throne. And so as per their agreement, he was executed. Solomon sought to rule his kingdom in fairness and enacted punishments that showed mercy to those who deserved death.Hear the Bible come to life as Pastor Jack Graham leads you through the official BibleinaYear.com podcast. This Biblical Audio Experience will help you master wisdom from the world's greatest book. In each episode, you will learn to apply Biblical principles to everyday life. Now understanding the Bible is easier than ever before; enjoy a cinematic audio experience full of inspirational storytelling, orchestral music, and profound commentary from world-renowned Pastor Jack Graham.Also, you can download the Pray.com app for more Christian content, including, Daily Prayers, Inspirational Testimonies, and Bedtime Bible Stories.Visit JackGraham.org for more resources on how to tap into God's power for successful Christian living.Pray.com is the digital destination of faith. With over 5,000 daily prayers, meditations, bedtime stories, and cinematic stories inspired by the Bible, the Pray.com app has everything you need to keep your focus on the Lord. Make Prayer a priority and download the #1 App for Prayer and Sleep today in the Apple app store or Google Play store.Executive Producers: Steve Gatena & Max BardProducer: Ben GammonHosted by: Pastor Jack GrahamMusic by: Andrew Morgan SmithBible Story narration by: Todd Haberkorn Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Ep1335 Shoftim 11:5-8

Seven Minutes of Nach

Play Episode Listen Later Jun 7, 2026 8:44

The Gilead elders make an offer to Yiftach

gilead shoftim

2 Samuel 16:15-17:29

Sermons - Mill City Church

Play Episode Listen Later Jun 7, 2026

Group Guide Use this guide to help your group discussion as you meet this week. 2 Samuel 16:15-17:29 Spencer Cary Download TranscriptMy name is Spencer and I am one of the pastors here. We are going to be in 2 Samuel chapter 16. We're going to go all the way through chapter 17 today. So, if you have a Bible around you, those black Bibles, you can grab one of those. We're going on page 306. and most of the text or all of this text will be on in those Bibles. We'll have some text on the screen as well. I'll try to cue when that comes up, but you can go ahead and follow along there. I've been following Jesus for 20 years at this point.And there are times when you follow Jesus long enough that just feel really dark. whether that's for suffering, whether that's affliction, sadness, all types of things that come upon us. But there are times where it just feels very very dark. But like the words we just sang, when darkness seems to hide his face, as the original hymn said, when darkness veils his lovely face. It's just this idea that if you follow God long enough, you're going to have times where you just don't feel the presence of God. you don't feel his goodness. And then when that happens, there are questions that begin to linger.Does God love me? Is he for me? Does he care about me? And those questions can linger in a way and surface and sometimes resurface when we are going through times that are difficult, when we're traveling through times that are very dark. Man, if you follow Christ long enough, that's that's going to happen. the reality of following Jesus this side of the fall. But then there are moments there are moments where God in the middle of darkness and his kindness breaks through. And it doesn't always mean that your circumstances get better. But in the middle of suffering, in the middle of what feels like hopelessness, God meets us in some wonderful and powerful ways.And that is the experience that all of God's people feel in the lifetime, the marathon of following Jesus. And maybe that's you right now. Maybe that maybe that's where you're at. That you just feel darkness and all the things that come with that we just talked about. And if that is you, and certainly for all of us, it will be us at some point. If that is you, then this part of the story of David is actually going to be, I think, wildly encouraging because David's been in it. We have I mean it's like week after week as we're following his story right now. He's living in the aftermath of his sin against Bathsheba and Uriah and he's dealing with the discipline of the Lord and it just feels unrelenting.But today, we're going to see that in the middle of all of this darkness that he's walking through, we're going to see God shine through like like a like like in a really difficult storm, like a light that just pierces through. We're going to see some hope that's found in that. And then as we look at this as Christians, we'll be able to take a step back and see that this is the hope that he has for us as well. So, I'm going to pray for us and then we're going to work through the story together. Heavenly Father, I thank you for the good news of the gospel that we just got to read, sing, and pray.I pray that you would help us as we seek to understand who you are even as we encounter the sufferings of this present life. So may you give us ears to hear in Jesus' name. Amen. All right. All right. So, before we jump into verse 15, let's recap a little bit where Mike took us last week. Absalom, the son of David, has been leading to this point a very successful rebellion, a civil war against his father, King David. And David has fled Jerusalem. Absalom has entered Jerusalem, is set up on the throne. And now Absalom is seeking to establish his reign. Picking up in verse 15. Now Absalom and all the people, the men of Israel came to Jerusalem and Ahithophel with him. Okay? So Absalom has a party of men of followers of leaders and it's going to be referred to as the men of Israel. And the most prominentfigure in that party is a man named Ahithophel. Ahithophel is a counselor to the king. He was a counselor to David. He was someone that David brought in to give wise counsel and advice. But now he's betrayed David and he's joined his son in this rebellion. And we don't really know why. Some have theorized that Ahithophel that when you follow his line, he has a son named Iliam. And that that might be the same Iliam that is the father of Bathsheba. That this might be the grandfather of Bathsheba and that he's exacting some type of revenge against David here. We don't know that to be true, but he has betrayed David and now he's joined in with Absalom and he's giving counsel to him. But he's not the only one seeking to give counsel to this new king. Verse 16.And when Hushai the Archite, David's friend, came to Absalom, Hushai said to Absalom, "Long live the king." Long live the king. Okay, we'll pause there. There are a lot of names as we're going to see in the story today. There's a lot of names last week, so some of this stuff is hard to track. But if you remember back from last week, Hushai is a spy that David has sent to disrupt Ahithophel. So in 2 Samuel 15, what we read last week in verse 34, this will be on the screen. It says, "But if you return to the city and say to Absalom, I will be your servant, O king, as I've been your father's servant in time past, so now I will be your servant. Then you will defeat for me the counsel of Ahithophel." This is David sending in Hushai to defeat the counsel of Ahithophel, which he knows is going to be veryhelpful to Absalom. And then in verse 37 it says, "So Hushai, David's friend, came into the city just as Absalom was entering Jerusalem." So that's what's happened here. He has sent he sent Hushai in to be rival counsel to Ahithophel to disrupt all of this. And Hushai, who's playing the part of double agent quite well, comes in immediately and says, "Long live the king."Now Absalom may be pretty but he's not that stupid because he knows that Hushai is a friend to David. So he responds verse 17. And Absalom said to Hushai, "Is this your loyalty to your friend? Why did you not go with your friend?" And Hushai said to Absalom, "No, for whom the Lord and this people and all that the men of Israel have chosen, his I will be, and with him I will remain. And again, whom should I serve? Should it not be his son? As I have served your father, so I will serve you." So Absalom says, " don't you like play golf with my dad?Like, aren't y'all boys? What's happening here? Why are you where why are you here?" And he's like, "No, no, no, no, no, no, no. I play golf with whoever sits on the throne. I'm for the position, not the man. And the Lord is with you and the people are with you. So I am with you. So I'm here to help you. And it's great. You're David's son. You're the next. So he plays the part of double agent quite well. He doesn't get immediately thrown out. The question is, is he going to be able to keep his cover as he's trying to infiltrate his way into Absalom's influence? Verse 20, then Absalom said to Ahithophel, "Give your counsel. What shall we do?" So he's looking to what's my next move is now that I've established my place in Jerusalem. And Ahithophel in verse 21 said to Absalom, "Go into your father's concubines whom he has left to keep thehouse and all Israel will hear that you've made yourself a stench to your father and the hands of all who are with you will be strengthened." Okay, that is a diabolical plan. All right, for a variety of reasons. First, this is a egregious sin. This is an egregious violation of the law. Leviticus 20:11 prohibits this. It gives the death penalty for anyone who will lay with his father's wife. And though concubines were seen as lesser status wives in the reign of the kings, they still are wives of the king. So what Ahithophel has recommended is a wicked and gross violation of the law. But as far as evil plans go in and its most brilliant base form, it's smart. From a worldly perspective, from a godless perspective, this is a massive power play. This is his way to show all the rebels that are fighting for him that I mean business.So it's wicked and it's evil and it's vile and it's obscene, but also it's very cunning. So Ahithophel gives him this counsel and Absalom listens. Verse 22. So they pitch a tent for Absalom on the roof. And Absalom went into his father's concubines in the sight of all Israel.Now in those days the counsel that Ahithophel gave was as if one consulted the word of God. So was all the counsel of Ahithophel esteemed both by David and by Absalom. And that's a way of saying that Ahithophel's counsel was so valued. It was like hearing the word of God. Meaning that the word of God says this, you do it. Ahithophel says this, you do it. And he recommends this rebellious, cunning, and wicked act. And Absalom does it. And they pitch a tent. And they work out this plan in front of all of Israel. But this is also fulfilling the prophecy of Nathan after David sinned with Bathsheba and murdering Uriah. For Nathan the prophet in 2 Samuel 12 will be on the screen. It says, "Thus says the Lord, behold, I will raise up evil against you out of your own house, and I will take your wives before your eyes and givethem to your neighbor, and he shall lie with your wives in the sight of the sun. for you did it secretly, but I will do this before this thing before all Israel and before the sun. So God gives up Absalom to his own sinful desires. And this brings judgment upon David and his house. And Ahithophel's counsel is followed. And he makes himself a stench to David and his followers. Now he's got more counsel to give becausenow they've got to reckon with David himself. And this is where we're going to see rival counselors Ahithophel and then Hushai is going to come into the scene and both of them function like the cabinet of the king. Right? So if you follow US history every US president has a cabinet and if you follow some of the biggest battles that have happened between these cabinet members. These are counselors to the king. The biggest one is is the original cabinet. So in Washington's presidency, he had Jefferson and then he had Hamilton. And both of them represented two very different political philosophies. That's why he put them in the counsel in the first place in the cabinet because he wanted to see two rival philosophies go at it, which didn't work out very well. They actually ended up forming two different political parties that came out of that. But if you follow theythey've written all this down. If you follow some of the history of how they fought, there were times where Hamilton would go on these 45minute monologues. He just go on and on and on and on and on and on and on and it's and this recorded that Jefferson would just be like head back just like just so annoying. And then there are times where Jefferson would win the day and he would get the influence of Washington and it's recorded that he would like sneer and like make faces at Hamilton, which is just funny because these are our founding fathers. of the people that helped found this nation and we can all act like children in our own sinful state at times. But that's not abnormal.That's not just US history. That's ancient history. That's happened for thousands of years that kings and presidents and prime ministers and sovereign leaders, they have counsel that they bring in often to oppose one another to find what is the best way forward. So what we're going to see is that type of cabinet battle here starting in verse one of chapter 17. Moreover, Ahithophel said to Absalom, "Let me choose 12,000 men, and I will arise and pursue David tonight. I will come upon him while he is weary and discouraged and throw him into a panic, and all the people who are with him will flee. I will strike down only the king, and I will bring all the people back to you as a bride comes home to her husband. You seek the life of only one man and all the people will be at peace and the advice seemed right in the eyes ofAbsalom and all the elders of Israel. Okay. So Ahithophel's plan I'll be honest is very very good. This is a good plan. He says listen we have a standing army of 12,000 men tonight that we can ride out of here. In fact, I will lead this. I will lead. You can stay put. I'll lead these 12,000 men. And we're going to catch David because David's not just traveling with his warriors. He's also traveling with his wives and probably some of his children, but with some grandchildren. He's got and they're tired and they're discouraged and they're weary. And he says, "You know what's going to happen?We're going to come upon them. It's going to be like lightning warfare. Boom. We're going to come in quick. And then all we have to do is cut off the head of the snake. All we have to do is take out David. There won't be lots of bloodshed. Only one man has to die. And then guess what? You're good. There's no more threat. Everyone gets behind you and you're the king. Now, that's an objectively good plan. All the commentators, everyone's looked at this and said, "That's a smart way to do this." And they hear it and they say, "Absalom likes this. The elders who are sitting in counsel like this." Now seems to be happening here is you got Absalom with a counsel of elders. Ahithophel comes in he makes his pitch and they like it and then he exits. Then verse 5, then Absalom said call Hushai the Architealso and let us hear what he has to say. So Ahithophel leaves Hushai comes in and now Hushai has to follow up a very very good plan. And that's difficult because if you have to outdo a very very good plan, you it's hard. If someone said, you know what, you're going to have to out-pitch ice cream as the staple dessert. That's a hard thing to do. You know why? Because ice cream is amazing. The fact that you can take the best part of milk, which is cream, and slowly turn it to where it's not so hard where it's just like ice, and it's not too soft that it's just this perfectly formed. and you could throw chocolate in it and all types of things. The person who pitches that idea originally, that's a good pitch. It's for you to come in and try to pitch something else. Unless milkhates you, it's a pretty good dessert. So that's what's that's happening here. Hushai is has to come in. He's going to outdo a very very good plan. Verse six. When Hushai came to Absalom, Absalom said to him, "Thus has Ahithophel spoken. Shall we do what shall we do as he says? If not, you speak." So they tell him, "This is Ahithophel's plan. Should we do what he says?" Verse 7. Then Hushai said to Absalom, This time the counsel that Ahithophel has given is not good, which I so appreciate as the opener to what we're about to read as a monologue because it's like Ahithophel has chosen poorly. Like, this is just no. It's the equivalent of Trump just saying wrong when someone says something it's just no immediately we're diverging this is not a good plan so then he starts to pitch his plan first by poisoning thewell of Ahithophel's plan verse eight said you know that your father and his men are mighty men and that they are enraged like a bear robbed of her cubs in the field. Besides, your father is an expert in war. He will not spend the night with the people. Behold, even now he has hidden himself in one of the pits or in some other place. And as soon as some of the people fall at the first attack, whoever hears this, hears it will say, "There has been a slaughter among the people who follow Absalom." Then even the valiant men whose heart is like the heart of a lion will utterly melt with fear. For all Israel knows that your father is a mighty man and those who are with him are valiant men. All right, pause.Hushai basically chooses fear. He chooses fear, which I don't know if you've been bombarded with the most obnoxious political ads that have been ra running right now, but all of them, 95% of them are fear-based because fear is effective. So, he chooses fear. He says, "You ever seen a bear robbed of her cubs? It's not good. You don't want to get in the middle of that." And he's enraged. They're furious. They're very upset with you, Absalom. So, I know you're thinking, "We've got the numbers. We've got 12,000 men. We can catch them off guard. First off, no you won't. You think David is stupid? He's hiding. He's off. You remember how you used to be hiding in the caves all the time? You think you're going to find him easily cut off the head of the snake? No. No.No. You He's not with his people. You're about to enter a hornets's nest. And let me tell you something. This is what he does. He says he says, "Your men, they've got strong hearts. Some of them courageous like lions. But the moment they start taking L's on the battlefield, the moment they start getting slaughtered, it's going to spread like wildfire. And everyone knows that David and his mighty men are bad. And that is 100% true. I mean, you look at some of their resumes, they are bad to the bone. And he says the moment that they start hearing that people are getting slaughtered, your men'll run.Seeing them not super courageous once they start getting defeated, that's a bad plan. So that's how Hushai begins. He poisons the well with fear. Okay. Now that he's poisoned it, he's going to shift to his plan. Verse 11. But my counsel is that all Israel be gathered to you from Dan to Beersheba as the sand by the sea for multitude, and that you go to battle in person. So we shall come upon him in some place where he is to be found and we shall light upon him as dew falls on the ground and of him and all the men who are with him not one will be left. If he withdraws into a city then all Israel will bring ropes to that city. We shall drag it into the valley until not even a pebble is to be found there.Okay. So what Hushai just did is he is wisely buying time. That's what he's doing. Ahithophel's plan is quick. That night he says, "No, no, no, no, no, no, no. You don't want that. Already talked about this. This is this this is going to go wrong for you. Also, Ahithophel's super old. You want him leading you to battle?" No. Here's what's going to happen. We're going to slow it down. We're going to go from Dan to Beersheba, which is basically from north to south. Think Maine to Florida. Okay? We're going to gather all the people of Israel, not 12,000 men, hundreds of thousands of men. We're going to get all of them in our side. that we're going to find David and we're going to surround him. He doesn't matter how mighty his men are, we will have numbers upon numbers upon numbers. And then once we surround him, we're going to win. And ifsomehow he escapes and he makes it to a city where there's where there's walls, guess what? We'll have so many people we'll take ropes, throw it over the wall, rip the walls down, bring all the pebbles into the valley, and guess what? We'll kill every single one of them. That's the option. That's the one you should choose. It's guaranteed. It's going to take some time. But let me tell you something. You don't want to go out without the numbers. That is Hushai's plan. And you've got these two different plans. One, which still, I'll be honest, is way better. Very quick. 12,000 men coming upon them as they've been running. They've got women and children with them. Boom. Kill David. Done. or Hushai's plan which is long drawn out buying time.What are you going to choose? Both are given. Verse 14. And Absalom and all the men of Israel said, "The counsel of Hushai the Archite is better than the counsel of Ahithophel. For the Lord had ordained to defeat the good counsel of Ahithophel so that the Lord might bring harm upon Absalom. So they choose Hushai's plan. And what we see in this is this is what David prayed for. If you remember back in 2 Samuel 15:31, it says, "And David said this on the screen." Oh Lord, please turn the counsel of Ahithophel into foolishness. He prays this and God answers this prayer. For it says, "The Lord had ordained to defeat the good counsel of Ahithophel so the Lord might bring harm upon Absalom." David's prayer is answered because ultimately God is going to bring judgment upon Absalom for his wickedness and his rebellion against David, the Lord's anointed king.So while that's happening, Hushai seemingly he's out of the room. So he's left the room. They're in here discussing this and they are making the decision that Hushai's plan is very very good. Hushai outside the room is now not going to wait to see what happens next because he heard Ahithophel's plan and that's a good plan. So he has got to get a word to David because David is exactly where Ahithophel said he would be. He's out in the open. He's not hiding. So that was all smoke and mirrors and he's got to get word to David in case Ahithophel's plan is taken. And that's what we pick up in verse 15. Then Hushai said to Zadok and Abiathar the priest. Okay, we got a lot of names here. Stay with me. Zadok and Abiathar are priests, Levitical priests that were loyal to David. So Hushai said to Zadok and Abiathar, the priest,thus and so did Ahithophel's counsel, Ahithophel counsel, Absalom and the elders of Israel. And thus and so have I counseled. Now therefore send quickly and tell David do not stay tonight at the fords of the wilderness but by all means pass over lest the king and all the people who are with him be swallowed up. So he says you've got to leave now. If they follow Ahithophel's plan they're going to catch you. You've got to get out of town. You got to get out of the wilderness. You got to get away as far as you can. So that's the word they give to Zadok and Abiathar. Verse 17. Now Jonathan and Ahimaaz were waiting at En-rogel. Okay. Jonathan and Ahimaaz are sons of Zadok and Abiathar. They are Levitical priests as well. And they're waiting at En-rogel which is just outside of Jerusalem. And it says a femaleservant was to go and tell them. And they were to go and tell King David for they were not to be seen entering the city. So what we have here is a chain of spies. One to the next to the next to the next to get to David. so that David and his crew can leave and flee danger. But verse 18, the young man saw them and told Absalom. So both of them went away quickly and came to the house at a man at Bahurim who had who had a well in his courtyard. And they went down into it. And the woman took and spread a covering over the well's mouth and scattered grain on it, and nothing was known of it. So while they're trying to get the message out, one of Absalom's men sees what happens. So they go, they hide in a well and then the woman very smartly spreadscovering over the well, puts grain on top of it, very much like Rahab and the spies in Jericho and hides them so that they can evade capture. Verse 20. When Absalom's servants came to the woman of the house, they said, "Where is Ahimaaz and Jonathan?" And the woman said to them, "They have gone over the brook of water." And when they had sought and could not find them, they returned to Jerusalem. So they successfully evade capture. Verse 21. After they had gone, the men came up out of the well and went and told King David. They said to David, "Arise and go quickly over the water, for thus and so has Ahithophel counseled against you."Then David arose and all the people who were with them, and they crossed the Jordan. By daybreak, not one was left who had not crossed the Jordan. So chain of spies works. They cross and guess what? They didn't even need to because Hushai's plan won. And Ahithophel's plan was defeated because God has determined to bring his judgment upon Absalom. And that plan is now in full effect. And Ahithophel cannot handle the defeat of this rival counselor. Verse 23. When Ahithophel saw that his counsel was not followed, he saddled his donkey and went off home to his own city. He set his house in order and hanged himself and he died and was buried in the tomb of his father. Now, it's possible that Ahithophel was so poisoned by his own pride and self-worth and his own great advice, his own great counsel that the moment that he's defeated, he can't handle it and hecommits suicide. It is also possible that at this point he may see the writing on the wall and that David is actually going to win this war and he'd rather take care of it himself as opposed to falling to David's sword. We don't know for sure. I lean towards the former. I think the text more I think pushes in that direction that when he says his counsel was not followed I think what's bound up in here is pride which just for the moment is a very good case study and a warning sign to anyone who puts their worth and their value and their work and their abilities and their talents and what they do. Because if you put so much value into those things and those things are taken from you, what you've done is you've set up an idol to worship. And when that idol is taken, it can lead you to some very dark places.And what this serves as is a cautionary tale to be mindful of not putting so much of your value and your worship and the things that you do because that's what I think Ahithophel does. And when his counsel is not followed because of his shame, he goes and takes his life.So let's finish out the chapter verse 24. Then David came to Mahanaim and Absalom crossed the Jordan with all the men of Israel. Now Absalom had set Amasa over the army instead of Joab. Amasa was the son of a man named Ithra the Ishmaelite who had married Abigail, the daughter of Nahash, the sister of Zeruiah, Joab's mother. and Israel and Absalom encamped in the land of Gilead. Verse 27. When David came to Mahanaim, Shobi the son of Nahash from Rabbah of the Ammonites and Machir the son of Ammiel from Lo-debar and Barzillai the Gileadite from Rogelim brought beds, basins and earthen vessels, wheat, barley, flour, parched, beans and lentils, honey and curds and sheep, and cheese from the herd. for David and the people with him to eat. For they said the people are hungry and weary and thirsty in the wilderness.The chapter ends with even though they're in the wilderness and even though they're on the run for their lives and even though it seems like things are going against them, God still cares and raises a people to provide provisions for them in the wilderness. And that closes chapter 17 to set up next week which we will see is the great battle between Absalom's men and David's men.Okay. So, if you've been with us the last few weeks, if you study this just in its immediate context, it's very hard to see the light in all of this darkness because we've seen so much of it. At this point, David has suffered for years under the discipline of God. He's watched his family be torn apart. He's watched his nation be torn apart. He's had to deal with the emotional agony of his own son leading a rebellion against him to murder him. I mean, he it's all these chapters, it's dark. And in the middle of all this darkness, in the middle of all this brokenness, in the middle of all of this pain and suffering, is a reminder that God is still for David.Because what commentators will say is that in all these chapters of suffering, right in the middle in verse 14 of chapter 17 is this shining light that breaks through the storm. So it says, "For the Lord had ordained to defeat the good counsel of Ahithophel, so that the Lord might bring harm upon Absalom." And that right there is the glimmer of hope that the wickedness and the evil, the dishonor of his father, the dishonor of his nation, the dishonor of his God, Absalom will be judged. and that the covenant that God made with David is remembered. Does David deserve to have favor? Absolutely not. Does God remember his covenant of favor towards David?Absolutely. That no matter how dark it has gotten, no matter how bad has gotten for David, God remembers his covenant to him. God remembers his covenant to his people. That is the glimpse of light that breaks through the storm of all of this darkness that we're reading. And as you take a step back as a Christian, it is a helpful reminder for us because we I think also we forget this because we will go through seasons of intense present darkness, of suffering, of affliction. And in the middle of all of the suffering, in the middle of the affliction, in the middle of all of it, those questions can linger. Is God for me?Does he care about me? Does he love me? Because it doesn't feel like it right now. If you follow Jesus long enough, you will have been there. And the good news is we don't just have the scriptures that testify to how God meets his people in the middle of darkness. We also have wonderful stories from church history. In the modern missions movement in the 19th century, there's a lot of missionaries that went out to parts of the world that were very difficult to reach and very difficult to reach with the gospel. One of them was named John Paton. John Paton was a missionary.Him and his wife, they went to the island of the New Hebrides Islands in the 19th century. It's an island that had zero Christians, had tribes that were cannibals. And he arrived on the island then not long after arriving there, his wife died. And then their infant son also died. And in his autobiography he says, "Then in a moment altogether unexpectedly, she died on March 3rd to crown my sorrows and complete my loneliness, the dear baby boy whom we had named after her father, Peter Robert Robson, was taken from me after one week's sickness on the 20th of March.Let those who have ever passed through any similar darkness as a midnight field for me, as for all others, it would be more than vain to try to paint my sorrows. And he just says that after losing his wife, after losing his son, after being obedient to the Great Commission to go and make disciples of nations that did not know him, that he felt such an intense loneliness it would be vain to try to paint and describe his sorrows. So he dug two graves with his hands and buried his wife and buried his son. and he's alone on an island with people who are trying to kill him.And this is what he writes. I'll put this on the screen. Stunned by that dreadful loss and entering upon this field of labor to which the Lord had himself so evidently led me, my reason seemed for a time almost to give way. The ever merciful Lord sustained me. But for Jesus and the fellowship he vouchsafed to me there, I must have gone mad and died beside that lonely grave. And it's such a wonderful reminder that even in the darkest of moments, even when all hope seems lost, even as he's buried his wife and his son and he's alone on an island under the threat of death, that in the intense darkness that he faced, Jesus Christ came. He says, "The ever merciful Lord sustained me. but for Jesus and the fellowship vouchsafed to me there, he says without it I would have gone mad beside that lonely grave and that story in some versions happenedover and over and over again and he continued and now that island for centuries at this point was converted to Jesus and has a legacy of Christ but God's people sometimes go through intense bouts of suffering I don't think any of us have ever faced anything like that. But in the middle of darkness, in the middle of complete what seems like hopelessness, God shines through to his people. And the reason he does this is because when he saves you and redeems you and seals you with the Holy Spirit, he never leaves or forsakes us. He is for us. And even though darkness may seem like it's prevailing, even though hope may seem like it is lost, even though it feels so sad and lonely, God is for you if you belong to him. He is for your good. It may not seem like it and he may not answer you with the circumstantialchange that you want, but God breaks through to his people. I don't know why some of you have suffered in the way that you have. I don't know why you feel the way that you do, but I do know that if you belong to Jesus Christ, he is with you. And my hope and my prayer is that you would sense it just like Paton did. That he would break through. That you would sense it just like David did and be reminded that just as David had a covenant that was made with him, we because we belong to Jesus Christ have a covenant that was made with us by his blood. that when Jesus Christ goes to the cross and sheds blood for our sin and then captures us and brings us into the family of God, that covenant is remembered and it is never forgotten that our God is for you. And wecelebrate that regularly and remember that as we come to the table. George is going to come up and we're going to prepare to take the Lord's Supper, which is a meal of remembrance that Jesus instituted and gave to the church. On the night that he was betrayed, he took bread and he broke it. He said, "This is my body that was broken for you." And then he took the cup of the new covenant. He said, "This is my blood that was shed for you that as often as you eat and drink this, you proclaim my death until I return." And Jesus gives us that meal to remember the covenant that was made with his blood.That God loves you so much that he gave up his one and only son. that you even in this life that is filled sometimes with suffering and darkness would persevere by faith trusting in the finished work of Christ and finding those moments where God encounters us with his presence and breaks through the dark questions that linger in our soul looking forward to a day when there will be no more questions like that because there will be no more suffering or sin or brokenness. There will only be him in eternity. So as a Christian you get to come to the table remembering the work of Jesus Christ as a reminder as a memorial as remembrance that he is for you. Even if it doesn't feel like it right now he is.So may you prepare your hearts and then in a moment you can come to the table. There's gluten-free at that table back there. If you do not belong to Jesus Christ, we don't want you to come to the table. We want you to come to Jesus. We want you to place your faith in him. We want you to see what it is like to walk with a God who loves you so deeply that he gave himself for you.And the invitation is for you to follow Christ. And if you want to know more about that, find me, find another pastor, find a Christian who brought you here today, and we can show you what it means to follow Jesus Christ. Let's pray. Heavenly Father, I pray that you might prepare our hearts to receive this meal of remembrance. God, I pray that you might help us, especially those of us that belong to you that are right now feeling so hopeless, feeling such darkness as so many of your people have done and felt. God, I pray that you would as they take this meal, would you break through the darkness, would you help them see that you love them, that you're for them, that they belong to you, that they're treasured by you.May they remember who you are. And for those who do not belong to you, I pray, God that you would compel them to faith in you this morning. We ask this in Jesus' name. Amen. Come when you are ready.

god jesus christ donald trump lord israel man bible washington christians holy spirit meaning jerusalem hamilton boom picking behold amen verse great commission supper leviticus king david arise heavenly father rahab bibles 2 samuel absalom gilead stunned ammonites oh lord that god levitical joab paton beersheba zadok rabbah ahithophel abiathar hushai amasa barzillai nahash mahanaim machir zeruiah gileadite ahimaaz bahurim when absalom so hushai then hushai

Interview with Bruce Miller, Showrunner of The Testaments

House Podcastica: A Game of Thrones Podcast

Play Episode Listen Later Jun 6, 2026 65:33

Reposted from The Handmaid's Tale Podcast: The Testaments, which you can find and subscribe to at: https://podcastica.com/podcast/the-handmaids-tale-podcast — What a thrill to once again talk to Bruce Miller, showrunner of The Testaments! His enthusiasm for the material is clear and infectious, and we hope you enjoy the conversation as much as we did. Among other things, Bruce talked about: Why Gilead is terrified of teenage girls Rowan Blanchard's performance as Shunammite, and why he thinks viewers eventually came around on the character Lydia's motivations, including whether she really believed she was protecting the women of Gilead The brutal stadium flashback, and the challenge of adapting such disturbing material without making viewers turn away What Agnes remembers about her mother, and how Gilead may have manipulated the memories of stolen children The cameos from Handmaid's Tale characters, and whether he thinks more of The Handmaid's Tale cast would want to return The visual storytelling of the series, from production design and costumes to color and cinematography Why we saw so little red this season What it was like working with the remarkable young cast Some intriguing hints about season two, including character backstories and a possible Gilead road trip And a lot more! Check out our other podcasts: If you like our coverage of The Testaments, we cover many other shows on our network at podcastica.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

tale handmaid gilead showrunners testaments shunammite reposted bruce miller rowan blanchard

Genesis 31:7-55

Thru the Bible on Oneplace.com

Play Episode Listen Later Jun 4, 2026 26:00

“The Lord will never give us up as long we keep coming back to Him.” That's what Dr. McGee shares as we see Jacob and his family flee to Mt. Gilead with Laban and his brothers in hot pursuit. What happens next? Join as the story unfolds.

lord mt mcgee gilead laban

Legend Biotech's CAR T-Cell Breakthrough: 100% Response Rate | Pharma and Biotech Daily

UBM Unleavened Bread Ministries

Play Episode Listen Later Jun 4, 2026 5:50

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're diving into some of the most significant advancements in scientific research, clinical trials, and regulatory landscapes within the industry. These developments are shaping the future of patient care and drug development significantly. Starting with Legend Biotech's LB2501, which achieved an impressive 100% response rate in a Phase 1 study for non-Hodgkin lymphoma using in vivo CAR T-cell therapy. This breakthrough highlights the transformative potential of CAR T-cell therapies in oncology, especially for B-cell lymphomas. Such success opens the door for accelerated regulatory pathways, offering hope to patients with limited treatment options. In another key development, JJP Biologics shared positive interim data from its Phase 1b trial of nebaprubart targeting CD89 in linear IgA disease. This monoclonal antibody is promising in treating autoimmune conditions by targeting specific disease mechanisms. Meanwhile, GSK's Velzatinib (IDRX-42) achieved a 61% response rate in Phase 1/1b trials for gastrointestinal stromal tumors, showing efficacy against cases resistant to treatments like imatinib. Johnson & Johnson's Nipocalimab met its primary endpoint in a Phase 2 study for systemic lupus erythematosus, underscoring the potential of FcRn blockade in managing autoimmune diseases. Zenas Biopharma's Phase 3 data for Obexelimab targeting CD19/FcγRIIB in IgG4-related disease further emphasizes the role of targeted therapies in managing complex autoimmune disorders. On the regulatory front, Foundation Medicine's FoundationOne Blood Test received FDA approval as a companion diagnostic for Pfizer's Talzenna (talazoparib) to treat prostate cancer with homologous recombination repair gene mutations. This approval underscores the growing importance of precision medicine and companion diagnostics in tailoring cancer treatments based on genetic profiles. Additionally, Lupin and Natco Pharma secured FDA approval for their generic version of Eribulin Mesylate Injection, essential for reducing healthcare costs and improving patient access to vital therapies. Eli Lilly's collaboration with Ascidian Therapeutics focuses on RNA exon editing for kidney diseases, potentially revolutionizing treatment approaches by correcting genetic errors at the RNA level. This partnership reflects a burgeoning interest in RNA-based therapies and their capacity to address unmet medical needs. Regeneron expanded its pact with CytomX Therapeutics to develop conditionally active bispecific antibodies, emphasizing innovation in oncology drug discovery. Such collaborations combine expertise across companies to expedite cutting-edge therapies' development. In terms of funding, NewLimit's successful $435 million Series C round aims to advance epigenetic reprogramming medicine towards human trials. This initiative highlights the burgeoning field of aging biology and its implications for extending healthy human lifespan through innovative therapeutic approaches. Similarly, Immu Biosciences raised $53 million to enhance its immunology platform using AI/ML technologies, underscoring AI and machine learning's critical role in accelerating drug development processes. Turning our gaze towards China's expanding influence on the global biotech stage, Akeso's presentation at ASCO 2026 marked a significant milestone as it became the first-ever Chinese dataset featured in a plenary session. This achievement underscores China's growing prominence in biotechnology and highlights its commitment to advancing innovative medical solutions globally. Simultaneously, Gilead's strategic partnership with Cencora aims to enhance access to CAR-T therapies like Yescarta and Tecartus by expanding their network of treatment centers. CAR-T therapies represent a paradigm shift in cancer treatment by offering personalized options for certain types of cancer. Despite challenges such as Roche's setbacks with its oral SERD drug giredestrant in breast cancer trials, innovation continues unabated. Zevra Therapeutics' launch of Miplyffa for Niemann-Pick disease type C exemplifies efforts to transform rare disease markets by improving patient outcomes through increased access and tailored treatment strategies. Finally, Eli Lilly's acquisition spree reflects broader trends where pharmaceutical companies increasingly integrate Chinese innovations into their development pipelines. This period marks a transformative phase characterized by collaboration between global pharma giants and Chinese biotechs, signaling an era where innovation is globalized and aimed at addressing critical healthcare challenges worldwide. These advancements reflect a dynamic period of innovation within the pharmaceutical and biotech industries. The focus on personalized medicine, targeted therapies, and groundbreaking technologies like RNA editing indicates a shift towards more precise treatment modalities. As these discoveries transition from research phases to clinical applications, they hold the potential to transform patient care significantly. Strategic partnerships and substantial funding initiatives illustrate a robust ecosystem supporting these innovations' rapid advancement. As regulatory bodies continue approving novel therapeutics and diagnostics, the emphasis on personalized healthcare will likely drive future developments, ultimately leading to improved patient outcomes worldwide. As we continue navigating these developments, it's clear that the pharmaceutical and biotech sectors are on the cusp of transformative breakthroughs that promise to redefine healthcare delivery across multiple domains. Thank you for tuning into Pharma Daily; stay informed and stay ahead.Support the show

Our Spiritual Growth - David Eells - UBBS 6.3.2026

Play Episode Listen Later Jun 3, 2026 126:47

Our Spiritual Growth (1) (audio) David Eells – 6/3/26 Glory of a Child Peter - 03/04/2008 (David's notes in red) In a dream, I found myself sitting at the side of a road, on the curb, and it was gloomy and dark. There were two gray wolves or beast-like creatures with massive fangs that subtly approached me from behind. (The beasts or wolves represent wicked men: (Luk.10:3)... I send you forth as lambs in the midst of wolves. (Ecc.3:18)... It is because of the sons of men, that God may prove them, and that they may see that they themselves are but as beasts.) They tried attacking me, but I don't remember if I tried to fight them off. What I do remember is that I ran into a dull red mini caravan, which so happened to be on the road, for protection and safety. (The van may represent a means of mobility having protection and safety. The dull red color represents the blood of Jesus.) As I was shutting the passenger door, one of the beasts lunged at me, but I managed to slam the door on it. (Enclosed in the blood) As a large portion of its body was caught in between the closed door, it suddenly morphed into a naked man inside the van (I could only see the upper body). This man had streams of blood running down from all over his body. (The persecutors wear as their works the blood of the saints. Eze.22:4 Thou art become guilty in thy blood that thou hast shed, and art defiled in thine idols which thou hast made.) During the entire time, I was panicking and fearful for my life and trying to survive. (David: As I have meditated on this dream, I see that the first man above is the natural man who is in total fear of losing his old life at the hands of the wicked. His reactions are natural but not based on the Word. The man below is the spiritual man, who is 'Christ in you' and whose actions are based in the Spirit and faith in the blood of Jesus. Together these make up who we are. We can choose to be led by either man, but the latter preserves life and promotes the Kingdom of God in and around us, making us safe. A confirmation that these two men are Peter, is that they are both sitting upon the curb.) Then my attention was suddenly drawn outside the van to a child who was sitting on the curb. (Mar.10:15) Verily I say unto you, Whosoever shall not receive the kingdom of God as a little child, he shall in no wise enter therein.) He had a large volume of golden curly hair. (Golden hair represents submission to the Lord [1Co.11:3-16] which strengthens us and sets a crown of glory upon us. (Jdg.16:17)... if I be shaven, then my strength will go from me, and I shall become weak, and be like any other man. The blessings of the Lord, riches, honor and life [Pro.22:4] are set upon His people as a crown of fine gold [Psa.21:3]. The child was sitting curled up in a ball (Representing humility and weakness; (2 Cor.12:9)...my power is made perfect in weakness.... (Jer.13:18)... Humble yourselves, sit down...), with his arms wrapped around his knees and with only his eyes to be seen. His eyes were emphasized, and I believe they were large and beautiful. (This represents spiritual eyes. (Son.4:1) Behold, thou art fair, my love; behold, thou art fair; Thine eyes are [as] doves behind thy veil... Doves represent seeing as the Holy Spirit does. We must see that we have been saved and sanctified. (2Pe.1:3) seeing that his divine power hath granted unto us all things that pertain unto life and godliness, through the knowledge of him that called us by his own glory and virtue). The lower part of his face (chin, mouth, nose) was tucked in behind his knees. (When attacked, we are not to defend ourselves by speaking foolishly. (Ecc.5:2) Be not rash with thy mouth, and let not thy heart be hasty to utter anything before God; for God is in heaven, and thou upon earth: therefore let thy words be few. (Isa.7:4)...Take heed, and be quiet; fear not.) He was innocent and harmless. He was clean. (He represents Christ in you, the spiritual man.) After I had finished observing, I noticed the same two beasts sneaking up behind him. At this point, there was no awareness of the man being in the van. (The spiritual man is not in danger and gives us a good example that we should not be in fear.) As I was still locked in the van for my own protection, I was filled with fear, yelling and screaming from the top of my lungs, trying to warn the child that he may run into the van. (Fear and anxiety, both a reflection of unbelief, only locked or bound me in the van. I was without any peace; I only had uncontrollable fear and anxiety. We must give in to the spiritual man and hold fast to the Gospel). I was hitting the window of the van to get his attention. He acknowledged me but didn't make the slightest movement, just sitting very still. (Exo.14:13)... Fear ye not, stand still, and see the salvation of the Lord, which he will work for you to-day: for the Egyptians whom ye have seen to-day, ye shall see them again no more for ever.) The beasts lunged at him, and there was still no movement on his part. The beasts were trying to bite him, but they couldn't get a grip. Their teeth were sliding off him. The beasts swung their claws at him, but there was no critical damage, only tiny scratches on the child, which were brought to my attention. (Innocence and submission to the Lord are his defense. (Pro.10:2)... righteousness delivereth from death.) Again, I was aware that I was still in the van, but I was also outside in the child's presence. The child still remained in the same sitting position as I had described and remained still for the entire time. He said nothing and didn't react in any way to defend himself. The beasts couldn't harm him. (Mat.5:39) ...resist not him that is evil: but whosoever smiteth thee on thy right cheek, turn to him the other also.) Suddenly, I looked behind this scene, and I noticed in the distance a small white house on a green grassy mount. (The house the spiritual man lives in is Christ [Heb.3:6]. We are to abide in Him, the Word, the secret place of the Most High.) In front of this house, there was a woman in a white robe inviting me, or beckoning, to partake of something. (The Bride's invitation to partake of the protection of resting in the (Psa.91) Passover by abiding in Christ.) The dream ends. I had the impression, maybe during or after the dream, that this lady looked like my Godmother (I come from an Orthodox Christian religion). Peter's Interpretation The woman in the white garment/robe who resembled my Godmother may very well be reflected by: (Pro.6:20) My son, keep the commandment of thy father, And forsake not the law of thy mother. The commandments of the Father, based on the New Testament, are life eternal (Joh.12:50), to believe in the name (meaning in Greek: “nature, authority, and character”) of Jesus Christ and love one another (1Jn.3:23). (Of course, the Word defines the steps of love.) I find that these commandments are united to be the same with one another. The law of the mother, based on the New Testament, is the law of faith (Rom.3:27), law of the Spirit of life (Rom.8:2), and the law of Christ (Gal.6:2). Like the commandments, these laws are the same with one another and can be united. Based on the order of events of the dream, I believe the child represents a manifestation and the fruit of the law of faith, of the Spirit, and of the commandments of the Father. All of these are certainly Christ. The child's characteristics and nature reveal the principles of living by faith and the Spirit of life in Christ, which are one with the commandments of the Father. If we submit to the Lord, remain humble, restrain our tongue, and see through our spiritual eyes or senses, we will be walking in Christ, fulfilling the spiritual laws (of faith and of the Spirit of life) and the commandments of the Father. All these spiritual laws are represented by the woman in the white robe who appeared to be my Godmother. She is associated with the white house on the grassy hill or mount. It may have seemed she was inviting me to partake of what was in the house, which is Christ. Just as that little child is associated with the woman, he must have been partaking from that house as well. If the woman represents all the spiritual laws and the commandments of the Father, she must also represent the spotless, blemishless Bride who is in perfect obedience to the laws and commandments of the Father. The Bride is the Word of God, who has manifested Jesus Christ. Her white robe must represent the righteous acts of the saints (Rev.19:8). The righteous acts are works of faith -- walking in the Spirit and not in the flesh. The child and the Bride are one nature because they manifest the wisdom of God, the Word of God; hence, Jesus Christ. Only as a 'child' can we enter the kingdom (Mar.10:15) and only those who walk in the Spirit. Those who are likened unto a child walk in the Spirit. One verse can describe this dream: (Exo.14:13) And Moses said unto the people, Fear ye not, stand still, and see the salvation of the Lord, which he will work for you to-day: for the Egyptians whom ye have seen to-day, ye shall see them again no more for ever. Whenever we are in tribulation or trial of any form, we should fear not, stand still, and see the salvation of the Lord. Use our imagination, see it spiritually, believe what the Word says about you. Rest. He has already saved you. Humble yourself, and He shall never forsake you because He is your Father. A father never forsakes his child (Psa.18:2; 94:12-14). (Mat.7:11) If ye then, being evil, know how to give good gifts unto your children, how much more shall your Father who is in heaven give good things to them that ask him? Thank you, Father, for Your grace and love! I pray that this dream has helped you renew your mind and imagination of who we truly are in Christ. May God bless you all. Fighting the Old Man Eric - 10/11/2006 (David's notes in red) In a dream, I was in a classroom, and an old man was teaching the class. (We can't let the old man teach, which in Christianity is most often the case. The class includes ourselves and all who associate with us.) He said to the class, “I don't like that Eric guy. I'm going to challenge him to a wrestling match.” (If we let the old man speak through us, he will gain confidence and strength against us and he will bring us under the curse.) Then he got up and came over to my desk and, looking down on me, said a second time, “I challenge you to a wrestling match”. He was about 7 feet tall, so I followed him outside. (The giant of our old life will challenge us and lead us into battle.) I noticed that nobody in my class was interested in watching the fight. (Most onlookers don't even know the battle between the spirit and flesh is going on inside us.) When I got outside, everything seemed deserted like a ghost town so we walked over to a playground. (As far as man is concerned, we are all alone in this battle.) We began to fight, and he threw a wild right swing at me and missed. (The right side symbolizes spirit, and the arm symbolizes power. This is a fight of spiritual power; the evil spirits in our flesh against the power of the Holy Spirit within us, joining together with our spirit.) I swung back with an uppercut, but missed his jaw because of his height. Then he got me in a headlock but I broke free and grabbed him in a headlock, and he also broke free. (The flesh and spirit taking turns controlling the mind is a double-minded life.) Then we separated and began to circle each other like two wrestlers. We cried out as warriors would cry in a battle and smashed into each other as two sumo wrestlers, but being equally matched in strength, we were both unable to get an advantage. We wrestled like this for what seemed like an hour, and finally we disengaged from each other, very exhausted. (In order to win this battle we must repent of our sins and confess them, which conquers the old fleshly man. 1Jn 1:9 If we confess our sins, he is faithful and righteous to forgive us our sins, and to cleanse us from all unrighteousness. Then we must believe the promises of our crucifixion and life in Christ, which strengthens the spiritual man. Without this, there will be no spiritual victory, only exhaustion. (Gal.2:20) I have been crucified with Christ; and it is no longer I that live, but Christ living in me...) Looking over, he said to me, “I think this is a draw”. Replying, I said, “I think you are right”, so we both proceeded back to the class, and he announced to them that the battle was a draw. (We can't afford to believe or speak that there is a draw for this leaves us unevenly yoked to the old man in a lukewarm life.) He then said arrogantly, “Eric stood up to me, but I have friends in high places, and I'm going to bring trouble for Eric; you wait and see!” (Gal.5:17) For the flesh lusteth against the Spirit, and the Spirit against the flesh; for these are contrary the one to the other; that ye may not do the things that ye would.) Suddenly, I found myself walking in a city I've never seen before. Somehow, I understood I was walking to my house. I remember the whole city was white, both buildings and cars, but the people walking around were dressed in black. (The unseen “kingdom of God has come nigh” but the people are walking in darkness.) When I arrived at my house, police lines were blocking my way. All manner of law enforcement officers were there. (If we don't beat the old man but leave him in control of the class, we break God's law and have to pay the penalty.) One who appeared to be in charge came up to me and asked, “Are you Eric?” I answered, “Yes, I am, but sometimes I'm not sure”. (We never really know who we are until the old man is dead.) He then said, “You are evicted, and you have to walk around in the street”. (The carnal man has taken over our house.) So then I looked toward heaven and cried out, “Lord, what am I to do without a house?” Then the dream ended. (This is a good teaching the Lord has given to us through Eric. We either put to death the old man, or we eventually lose controlling interest in this house we call a body, and maybe even the house we call a home. A more primitive lifestyle, enforced by the beast, is coming to the Church as a whole because of this lukewarm draw.) In Weakness We Win M.W.- 10/14/2008 (David's notes in red) In a dream, I was at a football game. I was part of a team. We were wearing white jerseys, and my teammates were younger kids, for the most part. I remember thinking when I saw my younger teammates, We are going to get killed! The field was on a hill, and it seemed like we were at a higher elevation. As we approached the field, I saw a sign that had the opposing team's name on it. The sign read “ASU”, which is Arizona State University, but during the dream, I didn't think about that; I just noticed “ASU”. If you look up their mascot, you will find that it is the Sun Devils; it is a picture of a devil with a pitchfork. So it was us versus the ASU Sun Devils. Right before the kickoff, I remember being very anxious and again thinking that this might not go well. At first, the field was muddy because I remember our uniforms having some mud on them. We received the ball first and, on a series of plays, marched down to the end of the field of the Sun Devils. I remember that as we moved toward their goal line, it seemed like I was a lot bigger than the ASU players. On the last play that scored the touchdown, I remember thinking, 'Should I play quarterback and maybe throw the ball?' Instead, it was a running play, and I was running just ahead of the running back blocking. It was interesting because I was a grown man, and it was like I was blocking little kids. I blocked several opposing players during the last play, and we scored. It started raining about then, and the Sun Devils forfeited the game. The score was 7-0. After we scored, we were so excited, and it was disappointing to see them forfeit, but it was a relief in a way. I remember watching the last van loaded with gear pull away in the rain and head down the hill. Many are wondering just before the big tribulation game against Satan's fearsome team, how such a small, weak, and immature-looking bunch on God's side could possibly survive, much less win. God's “power is made perfect in weakness.” “Not by might and not by power but by my spirit, saith the Lord.” It is “by my Spirit,” or another way to say it, it is the rain, the Latter Rain, and our weakness that will cause the enemy to forfeit the game. Remember Gideon's army, which God whittled down to 300 men so that in their weakness they would take on an army that was said to be, “like locusts for multitude; and their camels were without number, as the sand which is upon the sea-shore for multitude.” And what was God's reasoning? (Jdg.7:2) And Jehovah said unto Gideon, The people that are with thee are too many for me to give the Midianites into their hand, lest Israel vaunt themselves against me, saying, Mine own hand hath saved me. (3) Now therefore proclaim in the ears of the people, saying, Whosoever is fearful and trembling, let him return and depart from mount Gilead. So, children are the best to go against the enemy like little David went before Goliath. (Mat.18:3) and said, Verily I say unto you, Except ye turn, and become as little children, ye shall in no wise enter into the kingdom of heaven. (4) Whosoever therefore shall humble himself as this little child, the same is the greatest in the kingdom of heaven. We must be children in our own strength but wise beyond our years in God's strength. (1 Cor.14:20) Brethren, be not children in mind: yet in malice be ye babes, but in mind be men. (Eph.6:10) Finally, be strong in the Lord, and in the strength of his might. (11) Put on the whole armor of God, that ye may be able to stand against the wiles of the devil. (12) For our wrestling is not against flesh and blood, but against the principalities, against the powers, against the world-rulers of this darkness, against the spiritual [hosts] of wickedness in the heavenly [places]. (13) Wherefore take up the whole armor of God, that ye may be able to withstand in the evil day, and, having done all, to stand. (14) Stand therefore, having girded your loins with truth, and having put on the breastplate of righteousness, (15) and having shod your feet with the preparation of the gospel of peace; (16) withal taking up the shield of faith, wherewith ye shall be able to quench all the fiery darts of the evil [one]. (17) And take the helmet of salvation, and the sword of the Spirit, which is the word of God: (18) with all prayer and supplication praying at all seasons in the Spirit, and watching thereunto in all perseverance and supplication for all the saints. The Battle begins... My daughter had a dream, too. She and her grandmother were on a big roller coaster ride, which, in the natural, is scary and goes up and down, which represents the conditions many are about to endure. In the dream, I went up into a tower that overlooked a city. (Zion is called “the tower of the flock” and represents the Bride who will be over the rest of the people of God, as in Esther.) She said that I had a very serious look on my face. I was watching over the city, which I was charged to do by the military. (God's Generals will set watchmen for the enemy.) She joined me in the tower, but later she did go back to the roller coaster. The people in her dream were barefoot. (The Church will return to her primitive roots by not departing from the original Word given. Like Moses, they will take off their shoes to not be separated from Holy Ground.) The Lord Shows His New Models Amos Scaggs - 12/07/2008 (David's notes in red) In a dream, I was in a large showroom of a national car company. They were planning and redecorating for a promotion that would be so spectacular it would top any that had been done in the past, and it would keep escalating once it started. (The Lord is about to come out with His new models to show everyone what they, too, can drive. I believe the first-fruits Man-child ministry will be this demonstration. Jesus appeared to show what regeneration looked like.) I had my work done and books organized on my shelves, waiting to see what was going to transpire from this. (We've done the studying and put it in order. Now we are waiting to see what the Lord will show.) I knew it was going to be the biggest thing the world had ever seen, and it was only the first part of the year. I thought, since this is so early in the year, what will the end of the year look like? (The words, “What will the end of the year look like?” implies that something great will grow from this. The baby is born but matures quickly. Many models will be duplicates, symbolizing a revival. In Revelation chapters 12 & 14 the 144,000 man-child body will be duplicates of Jesus to do the greater works He spoke of.) As I was wondering what to do next, I met the Governor, whom I knew. (Jesus will govern from the throne in His earthly body of end-time Davids in a repetition of His-story. (Isa.9:6) For unto us a child is born, unto us a son is given; and the government shall be upon his shoulder: and his name shall be called Wonderful, Counselor, Mighty God, Everlasting Father, Prince of Peace. (7) Of the increase of his government and of peace there shall be no end, upon the throne of David, and upon his kingdom, to establish it, and to uphold it with justice and with righteousness from henceforth even forever. The zeal of Jehovah of hosts will perform this.) As I was concerned about what to do next, the Governor said, “Don't worry about a thing. Watch me and you will be doing the same things as I do very soon.” (The Governor is a role model and is coming in His Man-child company to be a role model for others to follow in His same steps. (1Jn.2:5) but whoso keepeth his word, in him verily hath the love of God been perfected. Hereby we know that we are in him: (6) he that saith he abideth in him ought himself also to walk even as he walked. The Governor said, “This is what I have planned; this is the beginning”. (The words, “this is the beginning,” imply many vehicles will be produced like these models, meaning a revival will spread from here.) I also thought I had something to do with the Buick showroom. David Buick was an inventor and also formed the Buick Mfg. Co. He and William Durant formed the Buick Motor Co., which is now known as General Motors. Durant was a productionist, and Buick was a perfectionist. Buick left the company in 1906 (because it fell short of his expectations) and died broke in 1929. Had Buick been able to keep his shares in 1921, he would have been worth $10 million and today it would be incalculable. Kind of reminds me of Jesus. (He was also a perfectionist, desiring quality not just quantity in His models. He was disappointed in the direction the early Church took and lost His shares in it. He lost out to the productionist's assembly line Christianity mentality.) Buick was quite the ingenious type who had it all but died broke and still formed a new thing that no one had seen before (but we will see Jesus' new thing again very soon :0). Invincibility in Jesus G. W. - 11/20/2010 (David's notes in red) I was in a dream where David Eells and I were in the same house. He was explaining to me that we can get into a car crash and nothing will hurt us. I understood him to be teaching about faith. He then said, “Let's go down this hill to try it out”. We both agreed that we would get into this white truck. It began rolling violently down from the top of the hill. We both were outside of the truck cab in the bed -- I was in the front, and David was toward the back. All of a sudden, we both flipped off. David went backward, and I went forward. As it approached me, the nose of it was facing the ground while the bed of the truck was in the air. I knew that the back section was coming right at me, but I had plenty of time to get out of the way. Instead, I just lay there and watched this disaster come toward me. The whole weight of the truck came crashing down on my midsection. As I looked down, I wondered if this truck had cut me in two, but I felt no pain. David came over and pulled me out from underneath. I stood upon my feet, completely whole. David said, “It can't hurt your rib cage”. Naturally speaking, this seemed impossible; however, I realized that I never felt fear as the disaster unraveled. I had been given a dream very similar to this about invincibility a couple of years ago. Jesus and the Two Witnesses had this gift until it was their time to go. Jesus said, “No man takes my life; I lay it down”. We truly have God's protection if we abide in Him, just as Psalm 91 says. So this is not just a gift to the Man-child but something the Davids, as Man-childs, will teach to the saints, as the dream above appears to say. Some will enjoy this until the Lord comes. This invincibility can take many forms. Around the time of this dream, I was driving home from a meeting at night. I wasn't particularly sleepy, just slightly. As I got close to my house, I suddenly found myself waking up out of a sound sleep, seeing headlights bright in my face. Without thinking, I jerked the wheel to the right and swerved quickly into my own lane, just in time to miss the oncoming car. I was amazed that I could have been asleep at the wheel because I didn't even remember feeling tired enough to have to fight it off. I realized that this was supernatural and that the Lord had shown me that He would protect me without my even knowing about it. It was seconds before it would have been too late to miss a head-on collision. I also noticed, as G.W. did, that I never felt fear. After receiving G. W.'s dream, my daughter, Deborah, and I were on the porch swing talking. It was a common bench-type steel swing. It had a chain coming down from a wooden frame on each end of the bench to an S-hook. From there, a chain went to the front bottom of the bench, and another went to the back top of the bench on each end. As we spoke, I was suddenly thrown backward on my back on the deck, but my head slammed into the metal top of the AC unit, which was off the deck, but the top stuck up about six inches higher than the deck. It was with such force and noise that one would have thought my neck would have broken or my head crushed. On my side of the bench, as one chain held the front bottom, the other that held the back came out of the S-hook. This caused my side of the bench to flip violently backward. My daughter was holding on to her side with her legs wrapped around the bench seat. When she heard the noise and saw me down there, she asked, with big eyes and loudly, “Are you all right?” As I reached up to brace her, I was surprised to be able to say, “I'm just fine”. I then laughingly said, “The Lord said He would give His angels charge over me, lest I dash my foot against a stone, but He didn't say anything about my head”. She asked again, “Are you sure you're alright?” I said, “I'm sure”, as I reached back to feel the back of my head and felt no pain nor even a bruise. As I stood up, I realized that indeed the angels had perfectly protected my head and neck, which easily could have been broken. I never felt any fear, just joy. My daughter said, “There is no blood on the back of your head”. I said, “There isn't even a bruise”. As I began to examine the bench and chain, I saw something even more supernatural. The chain that came loose was in perfect shape, like new, with no wear and no broken links. It was the kind of chain most often used on swings. Each link had a partner, and they were stitched in the middle so that if one link broke, it was still tied to one more link. I was amazed to see there was no broken link. Naturally speaking, this would mean the chain had to come out of the S-hook. However, I examined the S-hook, and it was still closed in the S where the chain was missing. “WOW”, I said, “this is supernatural”. The chain could not be put back in the S because it was still closed up, so I grabbed a screwdriver to spread it open so the chain could be reinserted, but I could not pry it open at all; it was too thick to bend. So I put the S next to the post that held the swing and hammered the screwdriver into the S to spread it so I could put the chain in it. I had to drive it in about 3/4” to get it open enough. How did the chain get out of the S-hook? Only supernaturally! I thought, either the devil just tried to kill me and failed due to Father's faithfulness, or the Lord was just showing me He was keeping me safe. I am sure both were true. I indeed had been in a crash, and the Father kept me perfectly. PTL! By the grace of my God, I have been shot at, at close range by a professional assassin, but my angel slapped the bullet down as he told me. The one who sent the assassin confirmed this. In a wreck, I was thrown from a car going 70 mph, slid about 70 feet on concrete without a scratch, with witnesses. My tractor flipped on the side of our mountain and was going to roll, but impossibly straightened back up with me still in the seat. I believe in Father's guardian angels! More recently, Michael and I were unhitching a back blade, a heavy piece of steel, from the tractor. I got off the tractor and was standing about 15 feet from the blade. Michael was on the other side releasing it, and supernaturally it came flying very fast straight at my head. It hit me right on my nose with force and knocked me back another 10 feet to the ground. Michael said he knew I was dead, but to his surprise, I jumped to my feet like nothing had happened. I told him that what I felt was a finger on my nose pushing me to the ground very fast. My angel, no doubt. In the natural, because of the speed at which it came at me, I would have been dead anyway, but I never felt any pain or incurred any damage. Some of this was because the faction had come together to throw witchcraft at me, but failed. Many of them are dead now. Do you find it hard to believe that spiritual powers, good or bad, can take authority over the natural laws, as seen with this S-hook, my head and neck? Many have been learning that they have authority over physical laws concerning the body and laws of nature, through faith and the spoken Word. In the testimony section of our site are multitudes of testimonies of the saints' healing machinery, bodies, cars, and other physical things, changing weather, changing minds, etc. Jesus taught His disciples to take authority over the laws of nature and to teach others to do so because they are not under the curse. (Gal.3:13) Christ redeemed us from the curse of the law, having become a curse for us; for it is written, Cursed is every one that hangeth on a tree: (14) that upon the Gentiles might come the blessing of Abraham in Christ Jesus; that we might receive the promise of the Spirit through faith. (Mar.11:23) Verily I say unto you, Whosoever shall say unto this mountain, Be thou taken up and cast into the sea; and shall not doubt in his heart, but shall believe that what he saith cometh to pass; he shall have it. (24) Therefore I say unto you, All things whatsoever ye pray and ask for, believe that ye receive them, and ye shall have them. (And repent of any sin so you will have power.) (25) And whensoever ye stand praying, forgive, if ye have aught against any one; that your Father also who is in heaven may forgive you your trespasses. (26) [But if ye do not forgive, neither will your Father who is in heaven forgive your trespasses.] Jesus commanded His disciples to make disciples of all the nations and teach them to obey all things He taught them, even unto the end. (Mat.28:19) Go ye therefore, and make disciples of all the nations ... (20) teaching them to observe all things whatsoever I commanded you: and lo, I am with you always, even unto the end of the world. Now we, as His disciples, must teach disciples to obey all the teachings of Jesus and take authority over the physical laws of the curse to proclaim the Gospel. Amen.

Resisting Gilead - The Testaments - S1 E10 - Secateurs - Episode 49

Resisting Gilead

Play Episode Listen Later Jun 2, 2026 56:30

Join me as I discuss the season one finale of The Testaments, S1 E10, Secateurs, with Andy.

resisting gilead testaments

Akeso's Ivonescimab Shows 34% Death Risk Cut at ASCO | Pharma and Biotech Daily

House Podcastica: A Game of Thrones Podcast

Play Episode Listen Later Jun 2, 2026 5:26

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into a range of fascinating advancements in the industry, each with significant implications for future patient care and drug development. At the recent American Society of Clinical Oncology (ASCO) 2026 conference, Akeso's ivonescimab, a pioneering PD-1xVEGF bispecific antibody, demonstrated a 34% reduction in death risk when combined with chemotherapy for first-line lung cancer treatment. This marks a pivotal moment in cancer therapeutics, illustrating how bispecific antibodies can enhance treatment efficacy. The evolving landscape of cancer treatment continues to highlight the importance of these innovative approaches. Johnson & Johnson's Erleada has shown promising results in prostate cancer, achieving positive outcomes in its Phase 3 Proteus study. The trial emphasized the efficacy of Erleada when administered perioperatively to prostate cancer patients, indicating a shift towards more personalized and comprehensive care that incorporates targeted therapies before and after surgery. In another significant breakthrough, Lilly's Retemvo exhibited dramatic results in early-stage lung cancer with RET fusion-positive markers, reducing disease progression or death by 83% as adjuvant therapy. This underscores the critical role of molecularly targeted therapies for patients with specific genetic profiles, offering hope for improved survival outcomes. On the frontlines of infectious diseases, Shionogi's COVID-19 antiviral Xocova has received FDA approval as a post-exposure prophylactic. This milestone highlights the challenging yet dynamic landscape of antiviral drug development, offering a new tool in managing COVID-19 exposures after previous challenges in demonstrating effectiveness as a treatment. MannKind's inhaled insulin, Afrezza, has been approved for pediatric use. This approval could rejuvenate its market presence by providing a more convenient insulin delivery system aimed at improving adherence and glycemic control among younger patients. In oncology news, Pfizer's Talzenna combination therapy received broader FDA approval for castration-sensitive prostate cancer. This positions it as a competitive option against Johnson & Johnson's PARP inhibitor combination therapy. Additionally, AstraZeneca's Imfinzi and Imjudo combination showed promise in early-stage liver cancer by reducing disease progression risks by 30%, broadening immunotherapy applications. The market dynamics are also shifting with significant strategic movements like Eli Lilly's acquisition of Kelonia Therapeutics for $3.2 billion. This decision is driven by promising in vivo CAR-T data demonstrating unprecedented response rates and reflects the increasing importance of innovative CAR-T therapies in oncology. Eli Lilly's Kelonia Therapeutics' cell therapy showcased an impressive 100% response rate in a Phase 1 trial for relapsed or refractory multiple myeloma. This CAR-T therapy targets the BCMA antigen and could revolutionize treatment paradigms by offering more effective responses. Meanwhile, Pfizer's transformative research on RAS inhibitors holds potential to redefine treatment paradigms in pancreatic cancer—a notoriously difficult-to-treat type due to its complex biology. Revolution Medicines aims to maintain its leadership within this space amidst growing competition. Revolution Medicines also reported compelling results with their KRAS inhibitor, which nearly doubles survival rates for metastatic pancreatic cancer patients harboring KRAS mutations. Given the historically poor prognosis associated with pancreatic cancer, these findings represent a significant advancement in managing this aggressive type. In ovarian cancer research, Gilead's TUB-040 demonstrated a 61% tumor response rate for platinum-resistant ovarian cancer in a Phase 1 trial. This highlights the potential of antibody-drug conjugates (ADCs) to overcome resistance mechanisms and improve outcomes in difficult-to-treat cancers. Regulatory updates include Johnson & Johnson receiving FDA label expansion for Tremfya to inhibit structural joint damage in active psoriatic arthritis patients. This expansion provides broader treatment options for patients suffering from debilitating conditions by reinforcing the role of IL-23 inhibitors in autoimmune disease management. Strategic partnerships are also shaping drug development's future landscape. Notably, Servier's acquisition of Edgewise Therapeutics' muscular dystrophy unit underscores growing focus on rare diseases and neuromuscular disorders. Eli Lilly's agreements with Haisco Pharmaceutical and Hanmi Pharm reflect ongoing R&D investments aimed at expanding therapeutic portfolios across various indications. These developments illustrate a broader trend toward personalized medicine and targeted therapies that enhance treatment efficacy by leveraging specific genetic or molecular characteristics. Despite advancements, challenges remain as exemplified by Oculis' OCS-01 failing Phase 3 trials for diabetic macular edema—highlighting inherent risks in drug development. Overall, these updates underscore significant scientific progress and promise improvements in patient outcomes through novel therapeutic approaches and collaborative efforts within this vibrant industry landscape.Support the show

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Episode 1384: Brad Alexander, The Testaments

In Creative Company

Play Episode Listen Later Jun 2, 2026 25:21

Q&A on the Hulu series The Testaments with actor Brad Alexander. This sequel to "The Handmaid's Tale" follows Agnes and Daisy, two teens in Gilead who must navigate an elite preparatory school where obedience is brutally enforced. Their bond becomes the catalyst that will transform their lives.

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The Testaments S1E10 "Secateurs"

Play Episode Listen Later May 30, 2026 114:24

Reposted from The Handmaid's Tale Podcast: The Testaments, which you can find and subscribe to at: https://podcastica.com/podcast/the-handmaids-tale-podcast — A moving, satisfying, bittersweet season finale where these girls who've spent the season waking up to how oppressed they and the women of Gilead have been decided to take a stand. We loved it, and we have a lot to talk about. A huge thank you to everyone who listened and who wrote or called in. It's been a fantastic season of podcasting, and we really loved sharing the experience of this great new show with you guys! We've got one more episode left to go. We had intended on including all your feedback in this episode, but as we should've known, there's more than enough for a standalone episode, so that should be out sometime next week. Talk to you then. Mentioned: Bruce Miller interviewed by The Hollywood Reporter: https://www.hollywoodreporter.com/tv/tv-features/the-testaments-finale-creator-promises-june-hannah-reunion-1236606878/ Next up: Listener feedback for The Testaments S1E10 “Secateurs”. Let us know your thoughts! You can email or send a voice message to testify@podcastica.com. Or check out our Handmaid's Tale: Mayday Facebook group, where we put up comment posts for each episode, at facebook.com/groups/thtmayday. Or join our Discord where you can leave comments and chat with hosts and other listeners: https://discord.gg/6WUMt3m3qe Check out our other podcasts: If you like our coverage of The Testaments, we cover many other shows on our network at podcastica.com. Digging our podcast? A quick, free, and easy way to show support and help bump us up in the charts is to give us a rating or a review: On Apple Podcasts: https://podcasts.apple.com/us/podcast/the-handmaids-tale-podcast-the-testaments/id1610222002 On Spotify: https://open.spotify.com/show/5MbAApyqlk3gLJUTHNnIH9?si=74013f9e35c64f0e Or just search for “Podcastica Testaments” wherever you get podcasts. Show support and get ad-free episodes and a bunch of other cool stuff: patreon.com/jasoncabassi Or go to buymeacoffee.com/cabassi for a one-time donation. Thank you! Learn more about your ad choices. Visit megaphone.fm/adchoices

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Is Pastoring More Like a Startup or a Garden?

A Pastor and a Philosopher Walk into a Bar

Play Episode Listen Later May 29, 2026 42:39 Transcription Available

Text us your questions!Randy and Kyle sit down with Milwaukee pastor and author Matt Erickson to explore a different vision of pastoral ministry: not the pastor as CEO, brand manager, or religious expert, but the pastor as gardener. Matt's book, The Pastor as Gardener: A Renewed Vision for Ministry, grows out of real ministry pressure, including moral failures, church decline, the pandemic, and the strain of navigating racial justice and polarization in a multiracial congregation.We dig into why agrarian imagery in Scripture still has bite for modern life, even in an urban church context. The gardener metaphor reframes leadership around cultivation instead of control: planting and watering while admitting we can't manufacture growth. That shift changes what we celebrate, what we fear, and what we measure, especially when the visible “fruit” of ministry looks strong but the hidden “roots” of prayer, integrity, and interior life are neglected.From there, we talk about what shepherding can still mean today, why care for the sick and grieving often gets delegated away, and why pastors need space to evolve without being treated like they've failed. Along the way we touch Gregory of Nyssa, Marilynne Robinson's Gilead, and the pressure for pastors to project certainty in a world where nobody can be an expert at everything.Look for Part 2 of this conversation in a couple weeks.=====Want to support us?The best way is to subscribe to our Patreon. Annual memberships are available for a 10% discount.If you'd rather make a one-time donation, you can contribute through our PayPal.Other important info:Rate & review us on Apple & SpotifyFollow us on social media at @PPWBPodcastWatch & comment on YouTubeEmail us at pastorandphilosopher@gmail.comCheers!

Infectious Disease Puscast #107

Infectious Disease Puscast

Play Episode Listen Later May 29, 2026 37:42

On episode #107 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/7 – 5/20/26. Host: Daniel Griffin and Sarah Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral FDA Grants Accelerated Approval to Gilead's Hepcludex® (bulevirtide-gmod), the First and Only Approved Treatment for Chronic Hepatitis Delta Virus (HDV) (Gileadl) A Phase 3, Randomized Trial ofBulevirtide in Chronic Hepatitis D(NEJM) Study to Assess Efficacy and Safety of Bulevirtide in Participants With Chronic Hepatitis Delta (CHD) (NLM: ClinicalTrials.gov) Andes Hantavirus Outbreak on a Cruise Ship, 2026 (NEJM) Quick takes: Another hantavirus case, polio in 3 countries, NIAID head steps down (CIDRAP) Dolutegravir Reduces Human T-Cell Lymphotropic Virus Type 1 Proviral Load and Improves Neurological Outcomes in a Phase 2 Controlled Trial (CID) Dolutegravir Appears to Lower Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) Proviral Load: The Emerging Rational Approach to Treatment of HTLV-1–Associated Myelopathy (CID) Use of Dolutegravir for treatment of HTLV-1 (CID) Use of dolutegravir to treat people living with HTLV-1-associated myelopathy (HAM) (CID) Bacterial Urinary Tract Infection (UTI)-free and Recurrent UTI (rUTI)-Free Survivals Following Bladder Electrofulguration in Women With a History of Antibiotic-Refractory rUTI (OFID) Azithromycin for Preschoolers with Wheezing in the Emergency Department (JAMA) Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care (JAMA Internal Medicine) Fungal The Last of US Season 2 (YouTube) Changes in Epidemiology of Candidemia in the United States With a Focus on Candida auris (CID) Parasitic Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme (The LANCET) Ivermectin-Benzimidazole Prescribing Following Celebrity Endorsement (JAMA Network OPEN) Febrile Temperature Augents Ring-stage Plasmodium falciparum Adhesion to Brain Endothelial Cells (JID) An Increase in Imported Plasmodium vivax Malaria in New York City: Clinical and Demographic Trends Following Recent Migration (OFID) Miscellaneous The State of Physician Leadership (WittkKieffer) Infectious Diseases Fellowship Curriculum: IDSA Training Program Directors Community of Practice (TPDCOP), Curricular and Educational REsources Workgroup (CREW) (CID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

The Testaments S1 Finale: Bold, Brave & Strong as Hell. Ep 315

Screens in Focus Podcast

Play Episode Listen Later May 29, 2026 54:57

Dive into the bold, emotional, and revealing finale of The Testaments, where truths surface, identities shift, and long-standing connections come full circle in powerful ways. Diana and Sam break down the biggest character moments, emotional turning points, and the rising strength of the women pushing against Gilead's system. In This Episode: Character growth and shifting perspectives throughout the finale Agnes discovering the truth about her identity Daisy, June, and Agnes' deeply connected journey Becca's heartbreaking storyline and devastating sacrifices Women influencing women and challenging oppressive systems Aunt Lydia's evolving perspective and internal conflict Resistance, rebellion, and the rising courage of the younger generation Connections to The Handmaid's Tale and the larger universe Hope, change, sacrifice, and what the finale sets up moving forward (00:00) - Welcome & episode overview (01:00) - Initial reactions & finale insights (03:00) - Agnes learns the truth about her identity (06:30) - Daisy and June's bonding & revelations (07:00) - Daisy confronts Agnes about her true identity (09:00) - Women influencing women & shifting power dynamics (10:00) - Agnes confronts Aunt Vidala (11:00) - Aunt Vidala tells Lydia she doesn't have to be alone (12:00) - The girls losing innocence but gaining agency (13:00) - Aunt Lydia feels the weight of responsibility (15:00) - Agnes challenges everyone to help Becca (17:00) - Resistance, rebellion & collective female power (21:00) - Becca's heartbreaking storyline (25:00) - Becca's wedding intercut with her mother's sacrifice (28:30) - The indifference of Gilead's men (29:50) - Agnes and Becca's melancholy kiss (31:50) - June and Garth react to Daisy's actions (34:30) - Agnes' awakening: the truth about her mother (38:30) - Reflections on the season: hope, change & transformation (40:49) - Question of the Day (46:50) - TV & movie recommendations alt-J - Hunger Of The Pin: https://www.youtube.com/watch?v=dCCXq9QB-dQ Website: www.screensinfocus.comEmail: screensinfocus@gmail.com Instagram: @screensinfocusFacebook: Screens in FocusTikTok: Screens in FocusYouTube: Screens in Focus Feedback and TV/Movie Recommendations: Google Voice: (669) 223-8542 Free background music from JewelBeat.com: www.jewelbeat.com

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#193: Vaccines, Potions & Charlatans - Jewish Medicine in the 19th Century.

History for the Curious

Play Episode Listen Later May 28, 2026 58:37

The 1800s was an era when medicine sat at the crossroads of science, ruses and discoveries. New vaccines and medical impostors competed for public trust. People broke with tradition and created a new landscape. Mordecai Wolff Haffkine Haffkine stood out as an almost legendary figure. A Jewish bacteriologist, he developed and tested vaccines against cholera and bubonic plague, putting his life repeatedly at risk and fighting to save the lives of millions of people. Whereas Dr. Samuel Solomon showed how skilful wording and suggestion could build a reputation and a fortune. Although his contribution to public service is rather unknown, Liverpool remembers him to this day - on par with some of their other legends. We also look at what happens when medicine and surgery produce unexpected outcomes. What are the halachic ramifications? And how did the BBC cover a re-election campaign in Kentucky? Timestamps: - 0:00:00–0:00:31 — Opening advertisement read (Dr. Solomon). - 0:00:31–0:03:47 — Hosts intro: series overview and upcoming guests. - 0:03:47–0:08:36 — Start of Mordechai Wolf Hafkin biography (education, expulsion, Pasteur Institute). - 0:08:36–0:12:33 — Hafkin self‑inoculates and early cholera vaccine work. - 0:12:33–0:15:43 — Hafkin's large vaccination campaigns in India; plague vaccine development. - 0:15:43–0:23:00 — Political opposition, 1902 tetanus deaths, inquiry and character attack. - 0:23:00–0:31:44 — Scientific exoneration, later life, return to Orthodoxy, philanthropy, death (1930). - 0:31:44–0:45:06 — Dr. Samuel Solomon biography: origins, balm of Gilead, marketing, bought MD. - 0:45:06–0:46:44 — Solomon's social status, legacy, and mixed moral assessment. - 0:46:44–0:53:33 — Halachic case: wrong‑kidney removal that saved the patient; discussion of intent vs. outcome and liability. - 0:53:33–0:58:34 — Media segment: critique of BBC coverage of Thomas Massie's election loss. - 0:58:34 — Episode close; call for listener feedback (podcast@jle.org.uk) and preview of part 2.

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Season 4 - Ep.10: Mitral annular disjunction - The heart in high altitude

Play Episode Listen Later May 28, 2026 17:22

This episode covers: Cardiology This Week: A concise summary of recent studies The heart in high altitude Mitral annular disjunction Mythbusters: Weekend mortality Host: Rick Grobbee Guests: JP Carpenter, Kristina Haugaa, Silvia Ulrich Want to watch that episode? Go to: https://esc365.escardio.org/event/2563 Want to watch that extended interview on mitral annular disjonction, go to: https://esc365.escardio.org/event/2563?resource=interview Disclaimer ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Rick Grobbee, Kristina Haugaa, Nicolle Kraenkel and Silvia Ulrich have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Novo Nordisk, Pfizer, Sanofi, Servier, Takeda, Tecnimede, Viatris. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

canada ai english consulting pfizer calgary esc statements abbott astrazeneca bayer philips merck johnson johnson gilead ferrer novartis declarations novo nordisk sanofi medtronic gsk amgen zoll abbvie bristol myers squibb takeda european society msd high altitude boehringer ingelheim deutsche gesellschaft inari mitral bial daiichi sankyo annular edwards lifesciences servier bristol myers viatris alnylam sanofi aventis cardiology esc biotronik disjunction

Season 4 - Ep10: Extended interview on mitral annular disjunction

The Who Cares News podcast

Play Episode Listen Later May 28, 2026 10:43

Host: Rick Grobbee Guest: Kristina Haugaa Want to watch that extended interview on https://esc365.escardio.org/event/2563?resource=interview Go to: Want to watch that episode? Go to: https://esc365.escardio.org/event/2563 Disclaimer ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Rick Grobbee, Kristina Haugaa and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Novo Nordisk, Pfizer, Sanofi, Servier, Takeda, Tecnimede, Viatris. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

canada ai english consulting pfizer calgary esc statements abbott astrazeneca bayer philips merck johnson johnson gilead ferrer novartis declarations novo nordisk sanofi medtronic gsk amgen zoll abbvie bristol myers squibb takeda european society msd boehringer ingelheim deutsche gesellschaft inari mitral bial daiichi sankyo annular edwards lifesciences servier bristol myers viatris alnylam sanofi aventis cardiology esc biotronik disjunction

Ep. 3097: Mr. Swift Does Have a Ring to It

Play Episode Listen Later May 28, 2026 9:18

(airdate: 5.28.26) Today in celebrity chaos, the internet is debating whether Travis Kelce should become "Travis Swift" after marrying Taylor Swift this summer . . . and honestly, fans seem surprisingly into it. Meanwhile, Hulu renewed "The Testaments" for Season 2 before the first season even ended, proving audiences still can't get enough dystopian stress television. And over in Bachelor Nation, producers are reportedly scrambling to cast the next "Bachelor," even pulling contestants from Taylor Frankie Paul's delayed "Bachelorette" season. So somewhere in Hollywood right now, executives are juggling roses, Gilead, and possible monogrammed "Swift-Kelce" towels all at the same time. Voted 6th Best Entertainment News Podcast! Because being #1 is soooo overrated. And @HalleBerry Listen to the daily Van Camp and Morgan radio show at: https://vancampandmorgan.com/stations buy us a coffee

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239 - ICH Q12: What's Binding? Established Conditions and Post-Approval Changes

Combinate Podcast - Med Device and Pharma

Play Episode Listen Later May 27, 2026 10:45

In this episode, Subhi breaks down ICH Q12, the guideline focused on post-approval change management and pharmaceutical product lifecycle management.The core question behind ICH Q12 is simple: once a product is approved, what is actually binding, what is supporting information, and how should future changes be managed?This episode covers the major Q12 concepts, including reporting categories, Established Conditions, supporting information, Post-Approval Change Management Protocols, the Product Lifecycle Management document, and the role of the Pharmaceutical Quality System.Subhi also discusses why Q12 matters for drug-device combination products, where lifecycle changes may involve CMC information, device constituent parts, functional performance characteristics, and the broader control strategy.Key topics covered:Why post-approval change can become difficult after approvalHow ICH Q12 supports more predictable lifecycle managementReporting categories for post-approval CMC changesEstablished Conditions versus supporting informationExamples of EC candidates, including CQAs, CPPs, material attributes, methods, sites, and process informationWhy overcommitting or undercommitting ECs creates lifecycle riskHow PACMPs help companies plan future changesWhat belongs in the PLCM documentHow ICH Q12 applies to drug-device combination productsWhy a strong PQS is essential for making Q12 workTimestamps:00:00 Introduction to ICH Q1200:46 Why post-approval change gets difficult02:45 Reporting categories03:14 Established Conditions vs supporting information04:10 EC examples: CQAs, CPPs, methods, sites, and process information05:32 Post-Approval Change Management Protocols06:38 PLCM document08:08 Drug-device combination product callout10:11 PQS and change management10:28 Closing thoughtsQuestions or feedback? Email subhi@letscombinate.comSource referenced in this episode: ICH Q12, Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management, Final version adopted 20 November 2019. Screenshots shown in this video are from the ICH Q12 guideline and are included for educational commentary. https://database.ich.org/sites/default/files/Q12_Guideline_Step4_2019_1119.pdfSubhi Saadeh is the Founder and Principal at Let's Combinate, where he helps teams develop and control drug-device combination products by aligning quality systems, development, and regulatory expectations across drug and device domains. He is a consultant, auditor, trainer, and speaker with experience across Pfizer, Gilead, and Baxter, supporting the development and launch of combination products across vaccines, biologics, and generics.

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Gilead's Hepcludex FDA Approval Marks Milestone | Pharma and Biotech Daily

The Vine Community Church Sermon Podcast

Play Episode Listen Later May 27, 2026 6:13

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. The landscape of these industries continues to evolve with significant scientific advancements, regulatory breakthroughs, and strategic maneuvers that are reshaping drug development and patient care. One of the noteworthy developments is the U.S. FDA's recent approval of Gilead Sciences' Hepcludex (bulevirtide) for hepatitis D. This approval marks a comeback for Gilead after previous setbacks due to manufacturing and delivery issues, highlighting the critical importance of addressing regulatory feedback. It's a testament to persistence in overcoming manufacturing challenges to ensure vital therapies reach those in need. This approval signifies a milestone as it's the first FDA-approved therapy targeting chronic hepatitis D virus infection—a niche condition with limited treatment options. Similarly, Pfizer's Braftovi (encorafenib) is expanding its global reach beyond U.S. borders with regulatory approvals in the EU and Canada for colorectal cancer treatment. This broadening geographic footprint reflects a broader industry trend where companies aim to maximize the therapeutic impact of oncology drugs across diverse patient populations. Meanwhile, Astellas Pharma is navigating the looming patent cliff for its prostate cancer drug Xtandi by actively pursuing new licensing deals and implementing cost-cutting measures. This dual approach underscores a widespread industry strategy where companies balance acquisitions with operational efficiency to sustain growth. In the radiopharmaceutical sector, there's notable activity with Lantheus Holdings possibly being acquired by Curium for $7 billion. This potential deal underscores growing interest in radiopharmaceuticals due to their precision in targeting specific cancer types. Complementing this is Niowave's $75 million investment in a radiopharmaceutical isotope plant in Michigan, set to produce actinium-225 by 2028—an isotope crucial for targeted cancer therapies. Regulatory landscapes are also in flux with continued reforms at the FDA despite leadership changes. Initiatives like the Commissioner's National Priority Voucher program illustrate regulatory bodies' commitment to streamlining drug approvals and fostering innovation. On an international note, SK Bioscience is partnering with Colombia to locally produce the chickenpox vaccine Skyvaricella, enhancing vaccine accessibility through technology transfer. Similarly, Eli Lilly's acquisition spree in infectious disease research signals a robust push toward expanding its R&D pipeline for viral and bacterial pathogens. Eli Lilly has announced plans to acquire Curevo, Limmatech Biologics, and another vaccine company for up to $3.8 billion. This strategic acquisition underscores a commitment to enhancing capabilities in infectious diseases—a field that has gained focus post-COVID-19 pandemic. By integrating these companies, Eli Lilly aims to leverage their platforms and expertise for advanced therapeutic solutions against infectious diseases. In gene editing, Eli Lilly is preparing for a Phase 2 trial of a lipid-lowering gene editor from Verve Therapeutics, showing promising cholesterol reductions akin to PCSK9 inhibitors. This highlights gene editing's potential in addressing cardiovascular diseases. A significant development from Lilly's pipeline includes promising results from their base editor technology acquired through Verve Therapeutics—an exciting breakthrough suggesting substantial potential for gene-editing technologies addressing genetic disorders like high cholesterol. In oncology, AstraZeneca and Daiichi Sankyo's Datroway gained FDA approval for triple-negative breast cancer as a first-line treatment. This antibody-drug conjugate targets Trop2, demonstrating the potential of targeted therapy in difficult-to-treat cancers. Kura Oncology's combination therapy featuring darlifarnib and Krazati showed up to a 69% response rate in KRAS G12C-mutated solid tumors during Phase 1 trials, emphasizing precision medicine's potential in targeting specific genetic mutations driving cancer progression. In obesity management, Eli Lilly's retatrutide achieved Phase 3 success with bariatric surgery-like outcomes. The drug acts as a triple hormone receptor agonist, showcasing advancements in metabolic therapies targeting obesity—a condition linked with numerous comorbidities. Moderna's mFlusiva is poised for an FDA advisory committee review as an influenza preventative for older adults—an extension of Moderna's mRNA technology initially used against COVID-19. Collectively, these developments highlight an industry leveraging cutting-edge science and technology to tackle complex medical challenges. As pharmaceutical giants like Eli Lilly consolidate their positions through acquisitions and research collaborations, transformative advancements promise to reshape patient care across various therapeutic areas. These initiatives not only reflect the industry's dynamic nature but also its pivotal role in addressing unmet medical needs worldwide. Eli Lilly's recent strategic acquisitions underscore its commitment to advancing pharmaceutical innovations, particularly in vaccines and cholesterol management sectors. Acquiring three vaccine-focused biotech firms signifies substantial investment in expanding its vaccine portfolio—a move aligned with global immunization strategies. This follows hiring Peter Marks from the FDA, indicating a strategic focus on bolstering expertise within the vaccine domain. The company has been recognized by IDEA Pharma as a leader in pharmaceutical innovation—a testament to its robust pipeline and successful integration of scientific advancements into marketable therapies. Across oncology landscapes highlighted at ASCO conferences are exciting potentials like Summit Therapeutics and Akeso's potential Keytruda rivals that could reshape cancer treatment paradigms if proven effective. As pharmaceutical landscapes continue evolving rapidly through scientific strides tempered by regulatory hurdles—the current environment promises significant advancements offering new hope while demanding strategic agility within healthcare sectors globally.Support the show

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The Testaments S1 E9: Protection, Pain & Power, Ep 314

Screens in Focus Podcast

Play Episode Listen Later May 26, 2026 55:27

Diana and Sam dive into the intense and emotionally devastating penultimate episode of The Testaments. From Becka's shocking act of "divine justice" to Daisy's risky decision to expose Dr. Grove, Episode 9 forces every character to confront what they're willing to do in the name of protection. We unpack Agnes's emotional unraveling, the complicated morality behind Daisy's accusation, and the larger themes of justice, vengeance, and survival in Gilead. We also discuss the significance of the episode title "Marat Sade," possible clues about who really took Becka, and what all of this could mean heading into the finale. Question of the Day: When does protecting someone cross the line? Timestamps: 00:00 - Introduction and episode overview 01:17 - Becka's shocking discovery about her father 02:26 - Becka's act of violence as justice and her internal struggle 03:50 - Becka's journey to Agnes's house and her dissociation 05:38 - The meaning of "salvaging" and Gilead's brutal justice 06:41 - Agnes's emotional weight and her brave revelation 09:21 - Daisy's decision to accuse Dr. Grove 13:23 - Agnes and Daisy: trust, pain, and emotional fallout 15:40 - Protection as the central theme of the episode 21:13 - Who really took Becka? The Eyes, the Aunts, or someone else? 24:27 - Justice vs. vengeance in Gilead 28:42 - Garth, Aunt Lydia, and shifting loyalties 33:38 - Character standouts: Becka, Daisy, and Agnes 37:09 - QOTD: When does protecting someone cross the line? 39:05 - The blurred boundaries of morality in Gilead 42:49 - Listener thoughts and discussion 45:34 - Finale questions and predictions 46:15 - TV & movie recommendations Recommendations mentioned: TV Shows: Servant (Apple TV+) The Boroughs (Netflix) Dutton Ranch (Paramount+) Survivor 50 Finale Tell Me Lies (Hulu) The Walking Dead Movies & Documentaries: Untold UK: Jamie Vardy (Netflix) Marty, Life Is Short (Netflix) Join the conversation! Share your thoughts on YouTube or connect with us on social media @screensinfocus. Website: www.screensinfocus.comEmail: screensinfocus@gmail.com Instagram: @screensinfocusFacebook: Screens in FocusTikTok: Screens in FocusYouTube: Screens in Focus Feedback and TV/Movie Recommendations: Google Voice: (669) 223-8542 Free background music from JewelBeat.com: www.jewelbeat.com

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Resisting Gilead - The Testaments - S1 E9 - Marat Sade - Episode 48

Resisting Gilead

Play Episode Listen Later May 26, 2026 50:54

Join me as I discuss the latest episode of The Testaments, S1 E9, Marat Sade, with Jenni.

resisting gilead testaments marat sade

The Rising King

Play Episode Listen Later May 24, 2026

David Anointed King of Judah 2After this David inquired of the Lord, Shall I go up into any of the cities of Judah? And the Lord said to him, Go up. David said, To which shall I go up? And he said, To Hebron. 2So David went up there, and his two wives also, Ahinoam of Jezreel and Abigail the widow of Nabal of Carmel. 3And David brought up his men who were with him, everyone with his household, and they lived in the towns of Hebron. 4And the men of Judah came, and there they anointed David king over the house of Judah. When they told David, It was the men of Jabesh-gilead who buried Saul,5David sent messengers to the men of Jabesh-gilead and said to them, May you be blessed by the Lord, because you showed this loyalty to Saul your lord and buried him. 6Now may the Lord show steadfast love and faithfulness to you. And I will do good to you because you have done this thing. 7Now therefore let your hands be strong, and be valiant, for Saul your lord is dead, and the house of Judah has anointed me king over them. Ish-bosheth Made King of Israel 8But Abner the son of Ner, commander of Saul's army, took Ish-bosheth the son of Saul and brought him over to Mahanaim, 9and he made him king over Gilead and the Ashurites and Jezreel and Ephraim and Benjamin and all Israel. 10Ish-bosheth, Saul's son, was forty years old when he began to reign over Israel, and he reigned two years. But the house of Judah followed David. 11And the time that David was king in Hebron over the house of Judah was seven years and six months.

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Moving Forward Together in Faith

Hunter Street Baptist Church

Play Episode Listen Later May 24, 2026

Study Passage: Numbers 32Now the people of Reuben and the people of Gad had a very great number of livestock. And they saw the land of Jazer and the land of Gilead, and behold, the place was a place for livestock. 2 So the people of Gad and the people of Reuben came and said to Moses and to Eleazar the priest and to the chiefs of the congregation, 3 “Ataroth, Dibon, Jazer, Nimrah, Heshbon, Elealeh, Sebam, Nebo, and Beon, 4 the land that the LORD struck down before the congregation of Israel, is a land for livestock, and your servants have livestock.” 5 And they said, “If we have found favor in your sight, let this land be given to your servants for a possession. Do not take us across the Jordan.”6 But Moses said to the people of Gad and to the people of Reuben, “Shall your brothers go to the war while you sit here? 7 Why will you discourage the heart of the people of Israel from going over into the land that the LORD has given them? 8 Your fathers did this, when I sent them from Kadesh-barnea to see the land. 9 For when they went up to the Valley of Eshcol and saw the land, they discouraged the heart of the people of Israel from going into the land that the LORD had given them. 10 And the LORD's anger was kindled on that day, and he swore, saying, 11 ‘Surely none of the men who came up out of Egypt, from twenty years old and upward, shall see the land that I swore to give to Abraham, to Isaac, and to Jacob, because they have not wholly followed me, 12 none except Caleb the son of Jephunneh the Kenizzite and Joshua the son of Nun, for they have wholly followed the LORD.' 13 And the LORD's anger was kindled against Israel, and he made them wander in the wilderness forty years, until all the generation that had done evil in the sight of the LORD was gone. 14 And behold, you have risen in your fathers' place, a brood of sinful men, to increase still more the fierce anger of the LORD against Israel! 15 For if you turn away from following him, he will again abandon them in the wilderness, and you will destroy all this people.”16 Then they came near to him and said, “We will build sheepfolds here for our livestock, and cities for our little ones, 17 but we will take up arms, ready to go before the people of Israel, until we have brought them to their place. And our little ones shall live in the fortified cities because of the inhabitants of the land. 18 We will not return to our homes until each of the people of Israel has gained his inheritance. 19 For we will not inherit with them on the other side of the Jordan and beyond, because our inheritance has come to us on this side of the Jordan to the east.” 20 So Moses said to them, “If you will do this, if you will take up arms to go before the LORD for the war, 21 and every armed man of you will pass over the Jordan before the LORD, until he has driven out his enemies from before him 22 and the land is subdued before the LORD; then after that you shall return and be free of obligation to the LORD and to Israel, and this land shall be your possession before the LORD. 23 But if you will not do so, behold, you have sinned against the LORD, and be sure your sin will find you out. 24 Build cities for your little ones and folds for your sheep, and do what you have promised.” 25 And the people of Gad and the people of Reuben said to Moses, “Your servants will do as my lord commands. 26 Our little ones, our wives, our livestock, and all our cattle shall remain there in the cities of Gilead, 27 but your servants will pass over, every man who is armed for war, before the LORD to battle, as my lord orders.”28 So Moses gave command concerning them to Eleazar the priest and to Joshua the son of Nun and to the heads of the fathers' houses of the tribes of the people of Israel. 29 And Moses said to them, “If the people of Gad and the people of Reuben, every man who is armed to battle before the LORD, will pass with you over the Jordan and the land shall be subdued before you, then you shall give them the land of Gilead for a possession. 30 However, if they will not pass over with you armed, they shall have possessions among you in the land of Canaan.” 31 And the people of Gad and the people of Reuben answered, “What the LORD has said to your servants, we will do. 32 We will pass over armed before the LORD into the land of Canaan, and the possession of our inheritance shall remain with us beyond the Jordan.”33 And Moses gave to them, to the people of Gad and to the people of Reuben and to the half-tribe of Manasseh the son of Joseph, the kingdom of Sihon king of the Amorites and the kingdom of Og king of Bashan, the land and its cities with their territories, the cities of the land throughout the country. 34 And the people of Gad built Dibon, Ataroth, Aroer, 35 Atroth-shophan, Jazer, Jogbehah, 36 Beth-nimrah and Beth-haran, fortified cities, and folds for sheep. 37 And the people of Reuben built Heshbon, Elealeh, Kiriathaim, 38 Nebo, and Baal-meon (their names were changed), and Sibmah. And they gave other names to the cities that they built. 39 And the sons of Machir the son of Manasseh went to Gilead and captured it, and dispossessed the Amorites who were in it. 40 And Moses gave Gilead to Machir the son of Manasseh, and he settled in it. 41 And Jair the son of Manasseh went and captured their villages, and called them Havvoth-jair. 42 And Nobah went and captured Kenath and its villages, and called it Nobah, after his own name.

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Balm in Gilead

The 44

Play Episode Listen Later May 22, 2026 10:37

Send us Fan MailIn this episode, we unpack the meaning behind the song “There Is a Balm in Gilead” and the powerful Scripture it comes from in Jeremiah 8:22. Tracing the idea of “balm” through passages like Genesis and other places in Jeremiah, we discover it was a well-known source of healing yet it couldn't fix the deeper spiritual problem God's people faced. That tension points us to a greater truth: real healing isn't found in earthly remedies, but in God Himself. This episode challenges us to move beyond just singing the words and actually seek the healing that's been available all along.

god scripture god himself tracing gilead balm balm in gilead

David Bahnsen: Gilead, Prioritize Business Performance

Meeting of Minds Podcast

Play Episode Listen Later May 20, 2026 3:07 Transcription Available

At Gilead Sciences' 2026 annual meeting, the company faced a shareholder proposal from David Bahnsen, founder of The Bahnsen Group over the use of ESG and DEI metrics in executive compensation. Listen to David's presentation, urging the company to prioritize executive clarity and business performance over activist incentives. "Gilead does not need to be grabbing headlines or seeking activist plaudits over inclusion initiatives. Its core business, meeting the needs of humanity by combatting the world’s deadliest diseases, is a noble, commendable, and lifesaving model that every investor can and ought to be proud of. Gilead has done it so very well." Learn more about The Bahnsen Group at thebahnsengroup.com.See omnystudio.com/listener for privacy information.

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Escaping Gilead! - The Testaments Podcast (Episode 109)

Pod Clubhouse

Play Episode Listen Later May 20, 2026 77:12

THE TESTAMENTS – “Marat Sade” – As Daisy steps into a new role, she considers what she's willing to lose to help her friends. (Disney/Russ Martin)CHASE INFINITI The shortest episode of the season, but maybe the most layered. Right off the bat, Caroline and Paul dissect this episode’s name and what its use may imply. Some hints: it’s actually a derivation of a much longer name – The Persecution and Assassination of Jean-Paul Marat as Performed by the Inmates of the Asylum of Charenton Under the Direction of the Marquis de Sade, and it involves the French Revolution, an asylum, the Marquis de Sade, and the murder of a revolutionary. Go check out the Wikipedia entry for the movie based on the play here or about the play itself here. This is our favorite kind of episode to take apart and discuss all of the different parts that make it stand out. The deep title, the visual motifs, the foreshadowing – this episode had a LOT for the viewers to chew on and in one of the longest podcasts of this series so far, Paul and Caroline certainly have full… mouths? I’m not sure that metaphor works. We would never physically chew into the microphone during a podcast. I just mean to say that the podcast is dense this week. The Testaments 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 Follow the Show On Hulu | Facebook | Our Facebook Group | X Follow the Hosts on X Caroline | Paul This podcast was recorded, edited, and produced by Paul and Caroline Daley at Pod Clubhouse Studios and is a Pod Clubhouse Original Production.

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Growing Apostolic Ministry In A Spiritual Desert! ... Enlgish & Spanish

Apostolic Mentoring

Play Episode Listen Later May 19, 2026 50:44 Transcription Available

A spiritual desert doesn't mean ministry stops; it means we discover what really carries us. We sat down with Pastor Cody Mayo to unpack a striking image that reframes leadership for a noisy, skeptical age: camels. Camels aren't pretty, but they are built for sandstorms. In the same way, prayer, fasting, Scripture, and Spirit-led love look ordinary from a distance, yet they are the load-bearing practices that move people through harsh seasons and toward hope.We trace the theme across Scripture. Paul learned at the feet of Gamaliel—“the camel of God”—a reminder that mentorship and formation matter when the road gets rough. Joseph's lowest moment meets a caravan bearing the balm of Gilead, revealing ministry as healing on the move. Then Rebekah steps to the well, eyes open to the cost, and makes trip after trip to water ten camels. That steady service becomes her road to destiny; the very burdens she lifted end up carrying her to her bridegroom. Along the way, we explore a core warning from Leviticus: never consume what carries you. Don't cut the disciplines that sustain your calling just because the desert feels long.If you've wondered how to lead faithfully amid social media noise, post-pandemic fatigue, and cultural fragmentation, this conversation offers a clear path: tend to the carriers first. Kneel the camels at the well before you reach for the meal. Measure a church not by platform shine but by the ministry it sustains day after day. You were made for this moment, equipped to breathe in the storm and keep moving with healing in hand.If this resonated, share it with a friend, subscribe for more conversations like this, and leave a review with one takeaway you're carrying into the week.We love to hear from our listeners! Thank you! https://www.amazon.com/dp/1639030158?ref_=cm_sw_r_cp_ud_dp_VZBSV9T4GT4AMRWEWXJE&skipTwisterOG=1 Support the showhttps://www.youtube.com/@charlesgrobinettehttps://www.instagram.com/charles.g.robinette/https://author.amazon.com/bookshttps://charlesgrobinette.com/

The Testaments Ep 8: Broken, Brave, Becoming, Ep 313

Screens in Focus Podcast

Play Episode Listen Later May 19, 2026 62:05

Diana and Sam break down The Testaments Episode 8, "Broken," an emotionally devastating chapter centered on heartbreak, trauma, and the quiet acts of solidarity that push back against Gilead's control. From Agnes's painful match to Commander Weston and the symbolic plate-breaking ritual, to Daisy's desperate attempt to hide her period and avoid being married off, this episode explores what it means to be "broken" in both literal and emotional ways. Diana and Sam discuss Agnes's unraveling as she faces both personal loss and buried trauma, Daisy's growing panic and shifting purpose, and the heartbreaking bravery of Hulda as she speaks out against Dr. Grove. They also dive into the surprising depth of Shunammite, Aunt Lydia's subtle but significant shift, and the many ways the girls support one another in a world designed to keep them silent. Plus, a quick spotlight on the haunting use of "Sweet Jane" by Cowboy Junkies during one of Agnes's most revealing moments. What does Broken really mean in this episode, damage, survival, or the beginning of resistance? Timestamps: 00:00 - Introduction to episode themes and emotional landscape 02:00 - The significance of girl matches and social ceremonies in Gilead 04:00 - Agnes's fantasies versus reality and her emotional heartbreak 06:00 - The symbolism of Agnes smashing the plate and societal reshaping rituals 08:00 - Daisy's experience with her first period and its political implications 10:00 - The complexity of Shu's character and her quiet strength 12:00 - Gilead's reproductive control and Daisy's rebellion plan 14:00 - Agnes's emotional calmness and her quick adaptation to trauma 16:00 - The systemic abuse by Dr. Grove and character reactions 18:00 - Agnes's confrontation with Hulda and the importance of truth 20:00 - Fair treatment of the girls—support and societal control dynamics 22:00 - The wedding celebrations masking underlying trauma and fear 24:00 - Penny's distress and implications for her future in Gilead 26:00 - The dangerous secret of Penny's situation and systemic violence 28:00 - The importance of allies and hidden resistance in oppressive environments 30:00 - Agnes's relationship with Aunt Lydia and her cautious support 32:00 - The themes of systemic brokenness and female support as rebellion 34:00 - The importance of covert solidarity and friendship among the girls 36:00 - Character highlights: Shu's complexity and Hulda's bravery 38:00 - Reflection on systemic control, trauma, and resilience 41:30 - Celebrating wedding traditions and Question of the Day answers 46:00 - Anticipating upcoming episodes 49:00 - TV & Movie Recommendations (see below) 1:01:30 - Closing Thoughts TV Shows: Good Omens (Prime Video) — series finale Dutton Ranch (Paramount+) Vanished (MGM+) Rooster (HBO) The Perfect Match Season 4 (Netflix) Outlander (Starz) — final season Movies: We Bury the Dead (Hulu, 2026) The Crash (Netflix, 2026) Remarkably Bright Creatures (Netflix) Primate (Paramount+) Question of the Day: What's your favorite part of a wedding—food, dancing, ceremony, just leaving early, or something else? Website: www.screensinfocus.comEmail: screensinfocus@gmail.com Instagram: @screensinfocusFacebook: Screens in FocusTikTok: Screens in FocusYouTube: Screens in Focus Feedback and TV/Movie Recommendations: Google Voice: (669) 223-8542 Free background music from JewelBeat.com: www.jewelbeat.com

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483. The Epstein Files with The Nerve featuring Ria Lina, Carole Cadwalladr, Lucia Osborne-Crowley, Dan Whitlam and GeeJay - part one

Play Episode Listen Later May 18, 2026 68:47

The Guilty Feminist 483. The Epstein Files with The Nerve Presented by Deborah Frances-White and Ria Lina with special guests Carole Cadwalladr and Lucia Osborne-Crowley from The Nerve, poetry from Dan Whitlam and music from GeeJay Recorded 30 April 2026 at the Leicester Square Theatre in London. Released 18 May. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Ria Lina https://www.instagram.com/rialina_ https://www.patreon.com/cw/rialina https://rialina.com More about The Nerve https://www.instagram.com/the_nerve_news https://www.thenerve.news https://www.instagram.com/carole_cadwalladr More about Lucia Osborne-Crowley https://www.instagram.com/luciaoc https://luciaosbornecrowley.com https://www.waterstones.com/book/the-lasting-harm/lucia-osborne-crowley/9780008591229 More about Dan Whitlam https://www.instagram.com/danwhitlam https://www.danwhitlam.com More about GeeJay https://www.instagram.com/geejayuk https://geejay.uk https://soundcloud.com/geejayuk For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Road to Gilead at the Museum of Comedy. https://www.museumofcomedy.com/the-guilty-feminist/ The Guilty Feminist Meets Rose McGowan. https://www.charleston.org.uk/event/the-guilty-feminist Tracey Emin in Conversation. https://www.southbankcentre.co.uk/whats-on/the-guilty-feminist-tracey-emin-in-conversation/ Guilty Feminist at Ventnor Fringe. https://purchase.vfringe.co.uk/EventAvailability?EventId=37801 Edinburgh Fringe. https://tickets.gildedballoon.co.uk/event/14:6708/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of the AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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483. Bonus with Lucia Osborne-Crowley

Play Episode Listen Later May 18, 2026 49:08

The Guilty Feminist 483. Bonus Presented by Deborah Frances-White with special guest Lucia Osborne-Crowley from The Nerve Recorded 13 May 2026 via Riverside. Released 18 May. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Lucia Osborne-Crowley https://www.instagram.com/luciaoc https://luciaosbornecrowley.com https://www.waterstones.com/book/the-lasting-harm/lucia-osborne-crowley/9780008591229 For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Road to Gilead at the Museum of Comedy. https://www.museumofcomedy.com/the-guilty-feminist/ The Guilty Feminist Meets Rose McGowan. https://www.charleston.org.uk/event/the-guilty-feminist Tracey Emin in Conversation. https://www.southbankcentre.co.uk/whats-on/the-guilty-feminist-tracey-emin-in-conversation/ Guilty Feminist at Ventnor Fringe. https://purchase.vfringe.co.uk/EventAvailability?EventId=37801 Edinburgh Fringe. https://tickets.gildedballoon.co.uk/event/14:6708/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of the AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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483. The Epstein Files with The Nerve featuring Ria Lina, Carole Cadwalladr, Lucia Osborne-Crowley, Dan Whitlam and GeeJay - part two

Play Episode Listen Later May 18, 2026 53:47

Even More Listener Questions, Answered [Teaser]

Know Your Enemy

Play Episode Listen Later May 18, 2026 5:06

Listen to the rest of this premium episode by subscribing at patreon.com/knowyourenemy. As always, listeners asked more mailbag questions than we could respond to in one episode, so we continue answering them here for subscribers. In this second round we take up: a playlist of KYE's Straussian-related episodes; (Straussian) esoteric writing versus (French) death of the author and the art of writing (and interpretation); prose style—what it is, why it matters, its relationship to poetry, and the rhythms of Norman Maclean; a "Straussian" reading of Steely Dan; and why liberalism is (mostly) worth defending. Thank you to everyone who attended our live event in NYC on Thursday! We had a great time. Sources: Leo Strauss, Persecution and the Art of Writing (1952) — Thoughts on Machiavelli (1958) Stanley Rosen, Hermeneutics as Politics (1987) Wallace Stevens, "The Snow Man," Poetry, Oct 1921 Norman Maclean, A River Runs Through It and Other Stories (1976) — The Norman Maclean Reader (2008) Edmund White, Nocturnes for the King of Naples (1978) Marilynne Robinson, Gilead (2004) W.H. Auden, "Friday's Child," (1958) Sam Adler-Bell, "Can Liberalism Stop Being So Darn Liberal?" The New Republic, June 20, 2024.

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Come, Follow Me with FAIR – Deuteronomy 6–8; 15; 18; 29–30; 34 – Part 2 – Autumn Dickson

Mormon FAIR-Cast

Play Episode Listen Later May 15, 2026 11:55

The Promised Land You Can't Enter Yet by Autumn Dickson In the chapters this week, Moses is led to the top of a mountain where he is shown the promised land. Deuteronomy 34: 1, 4 1 And Moses went up from the plains of Moab unto the mountain of Nebo, to the top of Pisgah, that is over against Jericho. And the Lord shewed him all the land of Gilead, unto Dan… 4 And the Lord said unto him, This is the land which I sware unto Abraham, unto Isaac, and unto Jacob, saying, I will give it unto thy seed: I have caused thee to see it with thine eyes, but thou shalt not go over thither. Interestingly enough, despite the fact that the Lord led him there to show him the promised land, Moses wasn't allowed to go into the promised land because of prior disobedience. He had led the Israelites out of Egypt and across the wilderness. It had not been easy. At one point, Moses had even asked the Lord to kill him rather than deal with the Israelites anymore. Moses suffered plenty of hardship, and he learned many great and important lessons. But despite this, Moses was still not allowed to step foot in the promised land. The Lord held true to Moses' consequences for disobedience. According to modern revelation, Moses was translated and taken up to the Lord before the Israelites entered the homeland that was meant for them. Details are always key. One of the details this week is the fact that Moses was taken up into a mountain where he could overlook the promised land that he couldn't enter. Mountains in scripture are often compared to temples. Holy things often take place on the tops of mountains, and the Lord gives knowledge and power to some of His children in the tops of mountains. Hold that thought. I wonder how he felt looking over the lands that were meant to be the inheritance of the Israelites. Did it hurt him that he would not be joining them or had he come to terms with the consequences that had been laid out for his disobedience? Did it hurt to see what had been meant to be his inheritance? Did it hurt to see the promises of the Lord that he would not be receiving? Whether it hurt or not, I can assure you that it no longer hurts Moses. He was translated, and he ended up in a different promised land than he had pictured or seen on the top of that mountain. It was a better promised land. Yes, Moses is just fine. I have found a surprising pattern in my life. I have multiple friends who dislike the temple, not because they don't agree with what happens there, but because they can't see the promises of the Lord being fulfilled for them. I have friends who have faced infidelity or family members who don't want to participate in ordinances in the the temple. Going to the temple and hearing the promises that were meant to be theirs doesn't feel particularly good. It is painful to hear about it and desire it deeply and not have current access to it. I fully recognize that I have not been in their shoes, nor do I understand what it's like to feel barred from those promises. Even as I share my testimony of these things, I fully own that I dont understand what it's like to have to come to terms with feelings like that. But sometimes objectivity is precisely what is needed. Strong emotions can be so overwhelming that it's difficult to see the end from the beginning. So let me testify of the end. Moses did not enter into that promised land here. He could see it. He was so close, but it was something that wasn't available to him. I promise you that he's okay. More than that, I promise that he is far more than okay. The Lord has taken care of Moses beautifully. There are two specific promises I want to testify of if you are facing the same problem as Moses or my friends. If you feel that there is no happy ending in sight, these are the promises I want you to hold to. Promise one. There is a promised land available for you even if it feels like mortality is barring you from in it one form or another. Mortality is not strong enough to keep you from your Savior's ability to give you a joyful existence. He is mighty to save. He can take care of you. You are not actually barred from those promises. And in all honesty, you don't even have to wait to step foot in the promised land. Moses' disobedience was what kept him from the promised land, and even his own disobedience didn't ultimately keep him from eternal joy. If you feel innocently barred, then Satan is lying to you. Christ can offer peace and comfort right now. You can go to the temple and listen to the promises and cling to them. Find comfort in them. You don't have to know the how in order for those promises to take affect in your life. Those promises ARE for you even if you don't know exactly how they will look. And if you don't feel strong enough to cling to those promises, He has the power to bring peace even when it's illogical. You can go to the temple and call upon the blessings He promised you there. You can tell Him, “I'm here. I came like You asked. Can you help me feel peace?” And then allow Him to offer peace. Allow Him to comfort you. Unfortunately, sometimes promises of joy feel empty without our loved ones who refuse their own promises. Which brings me to promise two. The Lord can take care of those around us, just as He can take care of you. Elder Orson F. Whitney, an apostle, taught this: The Prophet Joseph Smith declared—and he never taught a more comforting doctrine—that the eternal sealings of faithful parents and the divine promises made to them for valiant service in the Cause of Truth, would save not only themselves, but likewise their posterity. Though some of the sheep may wander, the eye of the Shepherd is upon them, and sooner or later they will feel the tentacles of Divine Providence reaching out after them and drawing them back to the fold. Either in this life or the life to come, they will return. I don't believe the sealing power only applies to children. There is a reason we all get sealed together; I believe this likewise applies to spouses who have chosen to stray. The Lord has a plan for everyone who ever lived upon the earth to be sealed together. That sealing power is so strong. And in the meantime, He will sorrow with you. He knows what it's like to watch loved ones stray. He cannot force them to come back, but He knows how to succor you in your pain. He knows exactly how you feel, probably even stronger because His love is deeper. Take comfort in the fact that He has found eternal joy and hope. You can too. Looking at the promised land doesn't have to feel painful. I testify that if Moses had seen what was coming for him, any sting from being barred from the promised land would have been soothed. It would have had no power because Moses knew what the Lord had in store for him. We can be like Moses. If you could see the end, it would take away much of the sting for you as well. I testify that as we consciously strive to strengthen our testimonies of His promises, we find the balm He promised us now, not just in the next life. I testify that the Savior can deliver on His promises of eternal joy. I testify that the ending is beautiful. I testify that He knows how to reach our loved ones, and we can trust Him with them. Autumn Dickson was born and raised in a small town in Texas. She served a mission in the Indianapolis Indiana mission. She studied elementary education but has found a particular passion in teaching the gospel. Her desire for her content is to inspire people to feel confident, peaceful, and joyful about their relationship with Jesus Christ and to allow that relationship to touch every aspect of their lives. Autumn was the recipient of FAIR's 2024 John Taylor Defender of the Faith Award. The post Come, Follow Me with FAIR – Deuteronomy 6–8; 15; 18; 29–30; 34 – Part 2 – Autumn Dickson appeared first on FAIR.

Yesteryear with Caro Claire Burke

Play Episode Listen Later May 14, 2026 26:34

The Guilty Feminist Culture Club: Yesteryear Presented by Deborah Frances-White and very special guest Caro Claire Burke Recorded 28 April 2026 in London. Released 14 May. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Caro Claire Burke https://www.caroclaireburke.com https://www.waterstones.com/book/yesteryear/caro-claire-burke/9780008742768 For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Road to Gilead at the Museum of Comedy. https://www.museumofcomedy.com/the-guilty-feminist/ The Guilty Feminist Meets Rose McGowan. https://www.charleston.org.uk/event/the-guilty-feminist Guilty Feminist at Ventnor Fringe. https://purchase.vfringe.co.uk/EventAvailability?EventId=37801 Edinburgh Fringe. https://tickets.gildedballoon.co.uk/event/14:6708/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of the AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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482. Ten for Ten #10: Sara Pascoe

comedy museum gilead sara pascoe guilty feminist deborah frances white

Play Episode Listen Later May 11, 2026 55:03

The Guilty Feminist 482. Ten for Ten #10 Presented by Deborah Frances-White with special guest Sara Pascoe Recorded 9 April 2026 in London. Released 11 May. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Sara Pascoe https://www.instagram.com/sara.pascoe https://sarapascoe.co.uk For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Road to Gilead at the Museum of Comedy. https://www.museumofcomedy.com/the-guilty-feminist/ The Guilty Feminist Meets Rose McGowan. https://www.charleston.org.uk/event/the-guilty-feminist Guilty Feminist at Ventnor Fringe. https://purchase.vfringe.co.uk/EventAvailability?EventId=37801 Edinburgh Fringe. https://tickets.gildedballoon.co.uk/event/14:6708/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of the AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com Learn more about your ad choices. Visit megaphone.fm/adchoices

481. The Algorithm with Aoife Dunne and Adele Zeynep Walton - part one