Podcasts about Gilead

Play Episode Listen Later Jan 22, 2026 23:59

This episode covers: Cardiology This Week: A concise summary of recent studies What´s new in TAVI? Digital solutions in arrhythmias Mythbusters - Gratitude is heart healthy Host: Emer Joyce Guests: JP Carpenter, Davide Capodanno, Fleur Tjong Want to watch that episode? Go to: https://esc365.escardio.org/event/2528 Want to watch that extended interview on Digital solutions in arrhythmias, go to: https://esc365.escardio.org/event/2528?resource=interview Disclaimer: ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Yasmina Bououdina and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Emer Joyce has declared to have potential conflicts of interest to report: Alnylam, Bayer, Pfizer, Fire-1. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson. Fleur Tjong has declared to have potential conflicts of interest to report: Amsterdam UMC Innovation grant, Heath Holland TKI, Abbott, Dutch Research Council, Boston Scientific.

Season 4 - Ep1: Extended interview on Digital solutions in arrhythmias

Origins: Explorations of thought-leaders' pivotal moments

Play Episode Listen Later Jan 22, 2026 10:10

Host: Emer Joyce Guest: Fleur Tjong Want to watch that extended interview on https://esc365.escardio.org/event/2528?resource=interview Go to: Want to watch that episode? Go to: https://esc365.escardio.org/event/2528 Disclaimer: ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Yasmina Bououdina and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Emer Joyce has declared to have potential conflicts of interest to report: Alnylam, Bayer, Pfizer, Fire-1. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson. Fleur Tjong has declared to have potential conflicts of interest to report: Amsterdam UMC Innovation grant, Heath Holland TKI, Abbott, Dutch Research Council, Boston Scientific.

Francesca Samsel - Vulnerability, making a new language, and pursuing the irrational

Play Episode Listen Later Jan 20, 2026 58:44

Francesca Samsel is crafting a new language for our world. That is, she crosses art, science, and visualization to open new ways of understanding and engaging with the natural world, not just visually but across the sensorial spectrum. She recognizes the inextricably social element to this, too, and her work raises our capacity to collaborate, and in the process, alters our sense of what scientific inquiry is and can (and perhaps needs to) be. Her work as her life are teachers we need for the world we are walking into. Origins Podcast WebsiteFlourishing Commons NewsletterShow Notes:vulnerability (11:30)problem with the 'follow your passion' path (14:20)Ganymede (15:00)what she tells her students (15:50)art-science collaboration (16:00)Santa Fe Institute (21:20)James (Jim) Ahrens (24:00)Craig Tweedie (25:20)visual structure to see the complexity in data (29:00)Isaac Asimov 'that's funny' (30:20)the need for scientific breakthrough (31:20)Lia Halloran - your hand will physically guide you the way to breakthrough (31:30)the only mark that you determine as an artist is the first one (33:00)delivery-oriented society (34:30)"Stewardship of Global Collective Behavior" by Joseph Bak-Coleman et al. (40:00)visual vocabulary work (42:00)Art-Sci-Vis Lab at UT Austin (43:20)flourishing (47:00)Gilead by Marilynne Robinson (51:45)lightning round (48:00)Artist: Jon McCormick (work called "Fifty Sisters")Passion: geoscience and the complexity you find when you walk out of the doorHeart sing: fused glass, ice, and rockScrewed up: obliviousness to colleaguesFind Francesca online:Website UT AustinLogo artwork by Cristina GonzalezMusic by swelo on all streaming platforms or @swelomusic on social media

passion vulnerability pursuing stewardship irrational gilead isaac asimov ut austin new language ganymede santa fe institute marilynne robinson samsel

2025 Medical Breakthroughs: Gene Therapy for Baby KJ, Huntington's Disease Treatment, CAR-T Myeloma Success, and mRNA Vaccines Boosting Cancer Immunotherapy

Ask Doctor Dawn

Play Episode Listen Later Jan 9, 2026 53:03

Broadcast from KSQD, Santa Cruz on 1-01-2025: An emailer asks about omega-3 supplementation for memory at age 72. Dr. Dawn advises checking that fish oil capsules contain adequate DHA—at least 1,000 mg—since many omega-3 products have low DHA levels. She notes Medicare covers the same testing at standard labs as proprietary labs like OmegaQuant that charge patients directly. Beyond omega-3s, she emphasizes glucose control (hemoglobin A1c below 5.6) since the enzyme that breaks down insulin also clears beta-amyloid, and weight training to raise brain-derived neurotrophic factor (BDNF), which promotes new synapse formation essential for memory. Dr. Dawn reviews Popular Science's top 2025 health innovation: eye drops from Lens Therapeutics containing aceclidine that correct age-related farsightedness for 10 hours. The drops shrink the pupil to increase depth of field, improving near vision by three or more lines on eye charts within 30 minutes without affecting distance vision. Side effects include eye irritation, dimmed night vision, and headache. She describes Duke University's breakthrough allowing heart transplants from circulatory death donors using an on-table reanimation technique. This could expand the pediatric donor pool by 20%—critical since up to 20% of children die waiting for transplants. Dr. Dawn celebrates CAR-T immunotherapy for multiple myeloma, which saved her husband's life. Of 97 heavily pretreated patients, 38% achieved complete remission still present at five years, with over 50% total survival. The therapy removes T-cells, uses CRISPR to add receptors targeting cancer cell antigens, then reinfuses the modified cells. She highlights a UC Davis study showing remote blood pressure monitoring with home technology, education, and coaching dropped patients' average blood pressure from 150/80 to 125/74 in months—low-tech with high impact. Dr. Dawn explains the Nano Knife for prostate cancer, which uses localized electrical pulses delivered through thin wires to destroy tumors while sparing surrounding nerves. This minimally invasive approach could reduce erectile dysfunction and incontinence common with traditional surgery. She describes Gilead's Sunlenca, a twice-yearly injection for HIV prevention that's 99% effective. At $14,000 per injection in the US, proceeds help fund access in resource-limited countries where it can be distributed like a vaccination. Dr. Dawn discusses Journavx (suzetrigine), a new non-opioid pain medication working on sodium channels to block pain signals before reaching the brain. At $30 for 50 pills on GoodRx, it offers an alternative for surgical pain in patients with addiction history or genetic vulnerability to opioid dependence. She details the landmark case of Baby KJ, the first person to receive personalized CRISPR gene therapy. Born with a CPS1 enzyme deficiency causing toxic ammonia buildup, KJ was too small for liver transplant. Scientists identified his specific mutation and used CRISPR base editing delivered via lipid nanoparticles to correct a single DNA letter—changing an A to G—in his liver cells which restored enough function to be discharged home. Dr. Dawn reports surprising findings that COVID mRNA vaccines amplify cancer immunotherapy. Lung cancer patients who received COVID vaccination within 100 days of checkpoint inhibitor treatment had 56% three-year survival versus 31% for unvaccinated patients. The mechanism is unknown but may involve mRNA generally alerting the immune system. She revisits research showing Zostavax shingles vaccination reduced dementia risk by 20% over seven years. A natural experiment in Wales—where an age cutoff created comparable vaccinated and unvaccinated groups—provided strong evidence that preventing herpes zoster inflammation protects brain health. Dr. Dawn concludes with Huntington's disease breakthrough: microRNA therapy delivered by virus directly into the brain slowed disease progression by 75% over three years. The microRNA binds to Huntington protein mRNA, preventing ribosome translation and toxic protein production. Some patients returned to work; others expected to need wheelchairs are still walking.

Expanding Treatment Options for Breast Cancer: ADCs and Oral SERDs

ASCO Daily News

Play Episode Listen Later Jan 8, 2026 27:14

Dr. Monty Pal and Dr. Hope Rugo discuss advances in antibody-drug conjugates for various breast cancer types as well as treatment strategies in the new era of oral SERDs for HR-positive breast cancer. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist and vice chair of academic affairs here at the City of Hope Comprehensive Cancer Center, Los Angeles. Today, I'm thrilled to be joined by Dr. Hope Rugo, an internationally renowned breast medical oncologist and my colleague here at City of Hope, where she leads the Women's Cancers Program and serves as division chief of breast medical oncology. Dr. Rugo is going to share with us exciting advances in antibody-drug conjugates (ADCs) that are expanding treatment options in various breast cancer types. She'll also address some of the complex questions arising in the new era of oral SERDs (selective estrogen receptor degraders) that are revolutionizing treatment in the hormone receptor-positive breast cancer space. Our full disclosures are available in the transcript of this episode. Dr. Rugo, welcome, and thanks so much for being on the podcast today. Dr. Hope Rugo: Thank you. Pleasure to be here. Dr. Monty Pal: So, I'm going to switch to first names if you don't mind. The first topic is actually a really exciting one, Hope, and this is antibody-drug conjugates. I don't know if I've ever shared this with you, but I actually started my training at UCLA, I was a med student and resident there, and it was in Dennis Slamon's lab. I worked very closely with Mark Pegram and a handful of others. This is right around the time I think a lot of HER2-directed therapies were really evolving initially in the clinics. Now we've got antibody-drug conjugates. Our audience is well-familiar with the mechanism there but tell us about how ADCs have really started to reshape therapy for HER2-positive breast cancer. Dr. Hope Rugo: Yeah, I mean, this is a really great place to start. I mean, we have had such major advances in breast cancer just this year, I think really changing the paradigm of treating patients. But HER2-positive disease, we've been used to having sequenced success of new agents. And I think the two biggest areas where we've made advances in HER2-positive disease, which were remarkably advanced this year in 2025, have been in antibody-drug conjugates with trastuzumab deruxtecan and with new oral tyrosine kinase inhibitors (TKIs) that have less of a target on EGFR and more on HER2, so they have an overall more tolerable toxicity profile and therefore a potentially better efficacy in the clinic. At least that's what we're seeing with these new strategies that we couldn't really pursue in the past because of toxicities of the oral TKIs. So, although our topic is ADCs, I'm going to include the TKI because it's so important in our thinking about treating HER2-positive disease. In the metastatic setting, we've seen these remarkable improvements in progression-free and overall survival in the second-line setting with T-DXd, or trastuzumab deruxtecan, compared to T-DM1. And then sequencing ADCs with giving T-DXd after T-DM1 was better than an oral tyrosine kinase or a trastuzumab combination with standard chemotherapy. That was DESTINY-Breast03 and DESTINY-Breast02. So, then we've had other trials since then, and T-DXd has moved into the early-stage setting, which I'll talk about in just a moment. But the next big trial for T-DXd in HER2-positive disease was moving it to the first-line setting to supplant what has become an established treatment for now quite a long time: the so-called CLEOPATRA regimen, which used the combined antibodies trastuzumab, pertuzumab with a taxane as first-line therapy. And then we've proceeded on with maintenance with ongoing HP for patients with responding or stable disease. And we'd seen long-term data showing, you know, at 8 years there was a group of patients whose cancers had never progressed and continued improved overall survival. So, T-DXd was studied in DESTINY-Breast09, either alone or in combination with pertuzumab compared to THP. The patient population had received a little bit more prior treatment, but interestingly, not a lot compared to CLEOPATRA. And they designed the trial to be T-DXd continued until progression with or without pertuzumab versus THP, which would go for six cycles and then stop around six cycles, and then stop and continue HP. Patients who had hormone receptor-positive disease could use hormone therapy, and this is one of the issues with this dataset because, surprisingly in this dataset and one other I'll mention, very few patients took hormone therapy. And even in the maintenance trial, the HER2CLIMB-05, less than 50% took hormone therapy as maintenance. This is kind of shocking to me and highlights an area of really important education, that outcome is improved when you add endocrine therapy for hormone receptor-positive HER2-positive metastatic disease in the maintenance phase, and it's a really important part of treatment. But suffice it to say, you know, you're kind of studying continued chemo versus stopping chemo in maintenance. And T-DXd, as we all expected, in combination with pertuzumab was superior to THP in terms of progression-free survival, really remarkably improved. And you could stop the chemo with toxicity, but most people continued it with T-DXd. Again, not a lot of people got hormone therapy, which is an issue, and you stop the chemo in the control arm. So, this has brought up a lot of interest in trying to use T-DXd as an induction and then go to maintenance, much as we do with the CLEOPATRA regimen with hormone therapy. But it brings up another issue. So first, T-DXd is superior; it's a great treatment. Not everybody needs to have it because we don't know whether it's better to give T-DXd first or second with progression - that we need a little bit longer follow-up. But just earlier this week, interestingly, the third week of December, the U.S. FDA approved T-DXd in the DESTINY-Breast09 approach with pertuzumab. So as I mentioned earlier, there was a T-DXd-alone arm; that arm has not yet reported. So very interesting, we don't know if you need pertuzumab or not. So what about the maintenance? That's the other area where we've made a huge advance here. So, we all want to stop chemo and we want to stop T-DXd. You don't want somebody being nauseated for two years while they're on treatment, and also there's a small number of patients with mostly de novo metastatic HER2-positive disease who are cured of their disease. We'd like to expand that, and I think these new drugs give us the opportunity to improve the number of patients who might be cured from metastatic disease. So the first maintenance study we saw was adding palbociclib, the CDK4/6 inhibitor, to endocrine therapy and HP, essentially. There, we had a remarkable improvement in progression-free survival difference of 15.2 months: 29 to 44 months, really huge. At San Antonio this year, we saw data with this oral tyrosine kinase inhibitor tucatinib, already showed it was great in a triplet, but as maintenance in combination with HP, it showed also a remarkable improvement in progression-free survival. But the numbers were all shifted down. So in PATINA, the control arm was in the 24-month range; here it was the tucatinib-HP arm that was in the 25 months and 16 months for control. So there was a differential benefit in ER-negative and ER-positive disease. So I think we're all thinking that our ideal approach moving forward would be to give T-DXd to most patients, we see how they do, and treat to best response. And then, stop the T-DXd, start HP, trastuzumab, pertuzumab for ER-negative, with tucatinib for ER-positive with palbociclib. We also have early data that suggests that both approaches may reduce the development of brain metastases, an issue in HER2-positive disease, and delay time to progression of brain metastases as seen in HER2CLIMB-05 in very early data - small numbers, but still quite intriguing that you might delay progression of brain metastases with tucatinib that clearly has efficacy in the brain. So, I think that this is a hugely exciting advance for our patients, and these approaches are quickly moving into the early stage setting. T-DXd compared to standard chemo, essentially followed by THP, so a sequenced approach resulted in more pathologic complete responses than a standard THP-AC-type neoadjuvant therapy. T-DXd alone for eight cycles wasn't better, and that's interesting. We still need the sequenced non-cross-resistant chemo. But I think even more importantly, the data from DESTINY-Breast05 looking at T-DXd versus T-DM1 in patients with residual disease after neoadjuvant HER2-targeted therapy showed a remarkable improvement in invasive disease-free survival with T-DXd versus T-DM1, and quite early. It was a high-risk population, higher risk than the T-DM1 trial with KATHERINE, but earlier readout with a remarkable improvement in outcome. We expect to be FDA approved sometime in the first half of 2026. So then we'll get patients who've already had T-DXd who get metastatic disease. But my hope is that with T-DXd, maybe with tucatinib in the right group of patients or even sequenced in very high-risk disease, that we could cure many more patients with early-stage HER2-positive breast cancer and cure a subset, a greater subset of patients with de novo metastatic disease. Dr. Monty Pal: That's brilliant. And you tackled so many questions that I was going to follow up with there: brain metastases, etc. That was sort of looming in my mind. I mean, general thoughts on an ADC versus a TKI in the context of brain mets? Dr. Hope Rugo: Yeah, it's an interesting question because T-DXd has shown quite good efficacy in this setting. And tucatinib, of course, had a trial where they took patients with new brain mets, so a larger population than we've seen yet for the T-DXd trials, and saw that not only did they delay progression of brain metastases and result in shrinkage of existing untreated brain mets, but that patients who develop a new brain met, they could stay on the same assigned treatment. They got stereotactic radiation, and then the patients who were on tucatinib with trastuzumab and capecitabine had a further delay in progression of brain mets compared to those on the placebo arm, even after treatment of a new one that developed on treatment. So, I think it's hard. I think most of us for a lot of brain mets might start with the tucatinib approach, but T-DXd is also a very important treatment. You know, you're kind of trading off a diarrhea, some liver enzyme elevations with tucatinib versus nausea, which you really have to work on managing because it can be long-delayed nausea, and this risk of ILD, interstitial lung disease, that's about 12%, with most but not all trials showing a mortality rate from interstitial lung disease of just under 1 percent. In the early-stage setting, it was really interesting to see that with T-DXd getting four cycles in the neoadjuvant setting, a lot less ILD noted than the patients who got up to 14 cycles, as I think they got a median of 10 cycles in the post-surgical setting, there was a little bit more ILD. But I think we're going to be better and better at finding this earlier and preventing mortality by just stopping drug and treating earlier with steroids. Dr. Monty Pal: And this ILD issue, it always seems to resurface. There are drugs that I use in my kidney cancer clinic, everolimus, common to perhaps the breast cancer clinic as well, pembrolizumab, where I think the pattern of pneumonitis is quite different, right? What is your strategy for recognizing pneumonitis early in this context? Dr. Hope Rugo: Well, it is, and you know, having done the very early studies in everolimus where we gave it in the neoadjuvant setting and we're like, "Hmm, the patient came in with a cough. What's going on?" You know, we didn't know. And you have mouth sores, you know, we were learning about the drug as we were giving it. What we don't do with everolimus and CDK4/6 inhibitors, for example, is grade 1 changes like radiation pneumonitis, we don't stop, we don't treat it. We only treat for symptoms. But because of the mortality associated with T-DXd, albeit small, we stop drug for grade 1 imaging-only asymptomatic pneumonitis, and some of us treat with a half dose of steroids just to try and hasten recovery. We've actually now published or presented a couple of datasets from trials, a pooled analysis and a real-world analysis, that have looked at patients who were retreated after grade 1 pneumonitis or ILD and tolerated drug very well and none of them died of interstitial lung disease, which was really great to see because you can retreat safely and some of these patients stayed on for almost a year benefiting from treatment. So, there's a differential toxicity profile with these drugs and there are risk factors which clearly have identified those at higher risk: prior ILD, for example. A French group said smoking; other people haven't found that, maybe because they smoked more in France, I don't know. And being of Japanese descent is quite interesting. The studies just captured that you were treated in Japan, but I think it's probably being of Japanese descent with many drugs that increases your risk of ILD. And, you know, older patients, people who have hypoxia, those are the patients. So, how do we do this? With everolimus, we don't have specific monitoring. But for T-DXd we do; we do every nine weeks to start with and then every 12 weeks CT scans because most of the events occur relatively early. Somebody who's older and at higher risk now get the first CT at six weeks. Dr. Monty Pal: This is super helpful. And I have to tell you, a lot of these drugs are permeating the bladder cancer space which, you know, is ultimately going to be a component of my practice, so thank you for all this. We could probably stay on this topic of HER2-positive disease forever. I'm super interested in that space still. But let me shift gears a little bit and talk about triple-negative breast cancer and this evolving space of HR-positive, HER2-low breast cancer. I mean, tell us about ADCs in that very sort of other broad area. Dr. Hope Rugo: So triple-negative disease is the absolute hardest subset of disease that we have to treat because if you don't have a great response in the early stage setting, the median survival is very short, you know, under two years for the majority of TNBCs, with the exception of the small percentage of low proliferative disease subsets. The co-question is what do we do for these patients and how do we improve outcome? And sacituzumab govitecan has been one strategy in the later line setting that was shown to improve progression-free and overall survival, the Trop-2 ADC. We had recently three trials presented with the two ADCs, sacituzumab govitecan and the other Trop-2 ADC that's approved for HR-positive disease, datopotamab deruxtecan. And they were studied in the first-line setting. Two trials with SG, sacituzumab govitecan, those trials, one was PD-L1 positive, ASCENT-04. That showed that SG with a checkpoint inhibitor was superior, so pembrolizumab was superior to the standard KEYNOTE-355 type of treatment with either a taxane or gemcitabine and carboplatin with pembrolizumab for patients who have a combined positive score for PD-L1, 10 or greater. So, these are patients who are eligible for a checkpoint inhibitor, and SG resulted in an improved progression-free survival. The interesting thing about that dataset is that few patients had received adjuvant or neoadjuvant checkpoint inhibitor, which is fascinating because we give it to everybody now. But access is an issue and timing of the study enrollment was an issue. The other thing which I think we've all really applauded Gilead for is that there was automatic crossover. So, you could get from the company, to try and overcome some of the enormous disparities worldwide in access to these life-saving drugs, you could get SG through the company for free once you had blinded independent central review confirmation of disease progression. Now, a lot of the people who got the SG got it through their insurance, they didn't bill the company, but 80 percent of patients in the control arm received SG in the second-line setting. So that impacts your ability to look at overall survival, but it's an incredibly important component of these trials. So then at ESMO, we saw the data from SG and Dato-DXd in the first-line metastatic setting for patients who either had PD-L1-negative disease or weren't eligible for an immunotherapy. For the Dato study, TROPION-Breast02, that was 10 percent of the patients who had PD-L1-positive disease but didn't get a checkpoint inhibitor, and for the ASCENT-03 trial population it was only 1 percent. Importantly, the trials allowed patients who relapsed within a year of receiving their treatment with curative intent, and the Dato study, TB-02, allowed patients who relapsed while on treatment or within the first six months, and that was 15 percent of the 20 percent of early relapsers. The ASCENT trial, ASCENT-03, had 20 percent who relapsed between 6 and 12 months. The drugs were better than standard of care chemotherapy, the ADCs in both trials, which is very nice. Different toxicity profiles, different dosing intervals, but better than standard of care chemotherapy in the disease that's hardest for us to treat. And importantly, when you looked at the subset of early relapsers, those patients also did better with the ADC versus chemotherapy, which is incredibly important. And we were really interested in that 15 percent of patients who had early relapse. I actually think that six months thing was totally contrived, invented, you know, categorization and doesn't make any sense, and we should drop it. But the early relapsers were 15 percent of TB-02 and Dato was superior to standard of care chemo. We like survival, but the ASCENT trial again allowed the crossover to an approved ADC that improved survival and 80 percent of patients crossed over. In the Dato trial, they did not allow crossover, they didn't provide Dato, which isn't approved for TNBC but is for HR-positive disease, and they didn't allow, of course, pay for SG. So very few patients actually crossed over in their post-treatment data and in that study, they were able to show a survival benefit. So actually, I think in the U.S. where we can use approved drugs already before there's a fixed FDA approval, that people are already switching to use SG or Dato in the first-line setting for metastatic TNBC that's both PD-L1 positive for SG and PD-L1 negative for both drugs. And I think understanding the toxicity profiles of the two drugs is really important as well as the dosing interval to try and figure out which drug to use. Dr. Monty Pal: Brilliant. Brilliant. Well, I'm going to shift gears a little bit. ADCs are a topic, again, just like HER2-positive disease we could stay on forever. Dr. Hope Rugo: Huge. Yes. Dr. Monty Pal: But we're going to shift gears to another massive topic, which is oral SERDs. In broad strokes, right, this utilization of CDK4/6 inhibitors in the context of HR-positive breast cancer is obviously, you know, a paradigm that's been well established at this point. Where do we sequence in oral SERDs? Where do they fit into this paradigm? Dr. Hope Rugo: Ha! This is a rapidly changing area; we keep changing what we're saying every other minute. And I think that there are three areas of great interest. So one is patients who develop ESR1 mutations that allow constitutive signaling through the estrogen receptor, even when there's not estrogen around, and that is a really important mutation that is subclonal; it develops under the pressure of treatment in about 40 percent of patients. And it doesn't happen when you first walk in the door. And what we've seen is that oral SERDs as single agents are better than standard single-agent endocrine therapy in that setting. The problem that we've had with that approach is that we're now really interested in giving targeted agents with our endocrine therapies, not just in the first-line setting where CDK4/6 inhibitors are our standard of care with survival benefit for ribociclib and, you know, survival benefit in subsets with other CDK4/6 inhibitors, and abemaciclib with a numeric improvement. So we give it first line. The question is, what do you do in the second-line setting? Because of the recent data, we now believe that oral SERDs should be really given with a targeted agent. And some datasets which were recently presented, which I think have helped us with that, have been EMBER-3 and then the most recently evERA BC, or evERA Breast Cancer, that looked at the oral SERD giredestrant with everolimus compared to standard of care endocrine therapy with everolimus, where 100 percent of patients received prior CDK4/6 inhibitor and showed a marked improvement in progression-free survival, including in the subsets of patients with a short response, 6-12 months of prior response to CDK4/6 inhibitor and in those who had a PIK3CA pathway mutation. The thing is that the benefit looks like it's much bigger in the ESR1 mutant population, although response was better, PFS wasn't better in the wild type. So, we're still trying to figure that out. We also saw EMBER-3 with imlunestrant and abemaciclib as a second line. Not everybody had had a prior CDK4/6 inhibitor; they compared it to imlunestrant alone, but still the data was quite striking and seemed to cross the need for ESR1 mutations. And then lastly, we saw data from the single arms of the ELEVATE trial looking at elacestrant with everolimus and abemaciclib and showed these really marked progression-free survival data, even though single-arm, that crossed the mutation status. At least for the everolimus combination, abemaciclib analysis is still to come in the mutated subgroups. But really remarkable PFS, much longer. Single-agent fulvestrant after CDK4/6 inhibitor AI has a PFS in like the three-month range and in some studies, maybe close to five months. These are all at 10-plus months and really looking very good. And so those questions are, is it ESR1 mutation alone? Is it all comers? We'd like all comers, right? We believe in the combination approach and we're learning more about combinations with drugs like capivasertib and other drugs as we move forward. Everybody now wants to combine their targeted agent with an oral SERD because they're clearly here to stay with quite remarkable data. The other issue, so the second issue in the metastatic setting is, does it make a difference if we change to an oral SERD before radiographic imaging evidence of progression? And that was the question asked in the SERENA-6 trial where patients had serial monitoring for the presence of ESR1 mutations in ctDNA. And those who had them without progression on imaging could be randomized to switch to camizestrant with the same CDK4/6 inhibitor or stay on their same AI CDK4/6 inhibitor. And they showed a difference in progression-free survival that markedly favored camizestrant. But interestingly, the people who were on the standard control arm had an ESR1 mutation, we think AIs don't work, they stayed on for nine more months. The patients who were on the camizestrant stayed on for more than 16 months. And they presented some additional subset data which showed the same thing: follow-up PFS data, PFS2, all beneficial in SERENA-6 at the San Antonio [Breast Cancer Symposium]. So, we're still a little bit unclear about that. They did quality of life, and pain was markedly improved. They had a marked delayed time to progression of pain in the camizestrant arm. So this is all a work in progress, trying to understand who should we switch without progression to an oral SERD based on this development of this mutation that correlates with resistance. And, you know, it's interesting because the median time to having a mutation was 18 months and the median time to switch was almost 24 months. And then there were like more than 3,000 patients who hadn't gotten a mutation, hadn't switched, and were still okay. So screening everybody is the big question, and when you would start and who you would change on and how this affects outcome. Patients didn't have access to camizestrant in the control arm, something we can't fix but we have experimental drugs. We're actually planning a trial, I hope in collaboration with the French group Unicancer, and looking at this exact question. You know, if you switch and you change the CDK4/6 inhibitor and then you also allow crossover, what will we see? Dr. Monty Pal: We're coming right to the tail end of our time here, and I could probably go on for another couple of hours with you here. But if you could just give us maybe one or two big highlights from San Antonio, any thoughts to leave our audience with here based on this recent meeting? Dr. Hope Rugo: Yeah, I mean, I talked about a lot of those new data already from San Antonio, and the one that I'd really like to mention which I think was, you know, there were a lot of great presentations including personalized screening presented from the WISDOM trial by my colleague Laura Esserman, fascinating and really a big advance. But lidERA was the big highlight, I think, outside of the HER2CLIMB-05 which I talked about earlier in HER2-positive disease. And this study looked at giredestrant, the oral SERD versus standard of care endocrine therapy as treatment for medium and high-risk early-stage breast cancer. And what they showed, which I think was really remarkable with just about a three-year median follow-up, was an improvement in invasive disease-free survival with a hazard ratio of 0.7. I mean, really quite remarkable and so early. It looked as though this was all driven by the high-risk group, which makes sense, not the medium risk, it's too early. And also that there was a bigger benefit in patients who were on tamoxifen compared to giredestrant versus AI, but for both groups, the confidence intervals didn't cross 1. There's even a trend towards overall survival, even though it's way too early. I think that, you know, really well-tolerated oral drug that could improve outcome in early-stage disease, this is the first advance we've seen in over two decades in the treatment of early-stage hormone receptor-positive disease with just endocrine therapy. I think we think that we don't want to give up CDK4/6 inhibitors because we saw a survival benefit with abemaciclib and a trend with giving ribociclib in the NATALEE trial. So we're thinking that maybe one approach would be to give CDK4/6 inhibitors and then switch to an oral SERD or to have enough data to be able to give oral SERDs with these CDK4/6 inhibitors for early-stage disease. And that's all in the works, you know, lots of studies going on. We're going to see a lot of data with both switching 8,000 patients with an imlunestrant switching trial, an elacestrant trial going on, and safety data with giredestrant with abemaciclib and soon to come ribociclib. So, this is going to change everything for the treatment of early-stage breast cancer, and I hope cure more patients of the most common subset of the most common cancer diagnosed in women worldwide. Dr. Monty Pal: Super exciting. It's just remarkable to hear how this has evolved since 25 years ago, which is really the last time I sort of dabbled in breast cancer. Thank you so much, Hope, for joining us today. These were fantastic insights. Appreciate you being on the ASCO Daily News Podcast and really want to thank you personally for your remarkable contribution to the field of breast cancer. Dr. Hope Rugo: Thank you very much, and thanks for talking with me today. Dr. Monty Pal: You got it. And thanks a lot to our listeners today as well. You'll find links to all the studies we discussed today in the transcript of this episode. Finally, if you value the insights that you hear today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinion of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:   Dr. Monty Pal @montypal Dr. Hope Rugo  @hoperugo Follow ASCO on social media:       ASCO on X ASCO on Bluesky      ASCO on Facebook       ASCO on LinkedIn       Disclosures:     Dr. Monty Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Hope Rugo:   Honoraria: Mylan/Viatris, Chugai Pharma  Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer  Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx

Gilead Girls Tallow: Abby Jurgens & Megan Adams

Small Town Big Business Podcast

Play Episode Listen Later Jan 8, 2026 38:27

Gilead Girls: Building a Tallow-Based Skincare Business from ScratchIn this episode of 'Small Town Big Business,' hosts Jennifer Olson and Russell Williams interview Abby Jurgens and Megan Adams from Gilead Girls, a small business that produces tallow-based skincare products. Abby and Megan share the origins of their business, which started as a solution to personal health issues and evolved into a popular brand. The conversation covers their product development process, sourcing local ingredients, the challenges of entrepreneurship, and their passion for educating others on the benefits of natural products. The episode also features exciting news about Gilead Girls taking over Good Life Nutrition in Marion, Illinois.00:00 Welcome to Small Town Big Business00:50 Meet Our Special Guests: Abby and Megan from Gilead Girls01:01 The Journey of Gilead Girls: From Friendship to Business02:00 Discovering Tallow: The Healing Journey05:51 From Side Hustle to Market Success09:52 Challenges and Triumphs in Business13:38 The Healing Power of Tallow17:51 Overcoming Business Hurdles20:03 The Importance of Knowing Your Source20:48 Challenges with Pricing and Market Adaptation21:10 Expanding the Team and Overcoming Local Challenges23:22 Building Relationships with Local Farms23:58 Success in Local Stores and Community Impact25:50 Family Involvement and Entrepreneurial Spirit27:31 Future Growth and Exciting Announcements31:15 Educational Resources and Inspirations32:28 Accessing Our Products and Community Engagement36:07 Final Thoughts and GratitudeRecorded at EThOs Small Business Incubator and Co-working Spaces in Marion, Illinois.https://members.ethosmarion.org/ SUBSCRIBE TO THE PODCASTOur guest: https://www.facebook.com/profile.php?id=100093612317425SPECIAL THANK YOU TO OUR SPONSORS:Watermark Auto Group: https://www.watermark.auto/Fowler Heating & Cooling: https://fowlerheatingandcooling.com/Swinford Media Group: https://swinfordpublications.com/Arcadia Wealth Group: https://www.raymondjames.com/arcadiawealthgroupBanterra Bank: https://www.banterra.bank/Southern Illinois Now: https://southernillinoisnow.org/Produced by Union Street Artshttps://www.unionstreetarts.com/

January 6 -I've Never Heard That! Scriptures That WILL Transform Your Life: Song of Songs

Dr. Tom Curran Podcast

Play Episode Listen Later Jan 6, 2026 54:08

Dr. Tom Curran reflects on scripture passages that will transform your life. Tom shares several insights from Song of Songs chapters 4-6 about how much Jesus loves YOU!You have ravished my heart, my sister, my bride; you have ravished my heart with one glance of your eyes, with one bead of your necklace. (Song of Songs 4: 9)Turn your eyes away from me, for they stir me up. Your hair is like a flock of goats streaming down from Gilead. (Song of Songs 6: 5)

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464. ROAD TO GILEAD: Reform's Ties to the ADF with Susan Wokoma and special guests Jane Bradley and Elizabeth Dias – part two

Play Episode Listen Later Jan 5, 2026 41:49

The Guilty Feminist 464. Reform's Ties to the ADF - revisited Presented by Deborah Frances-White and Susan Wokoma with special guests Jane Bradley and Elizabeth Dias. Recorded 9 December 2025 via Riverside. Released 5 January. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Susan Wokoma https://www.instagram.com/susiewoosie12 https://www.instagram.com/p/DFK7aZDI5Sb More about Jane Bradley https://www.instagram.com/janebradleynyt https://www.nytimes.com/by/jane-bradley More about Elizabeth Dias https://www.instagram.com/elizabethjdias https://www.nytimes.com/by/elizabeth-dias For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Open Space Event, 17 January. https://www.eventbrite.co.uk/e/road-to-gilead-open-space-event-tickets-1976897741361 Open Space in Basingstoke. https://www.proteustheatre.com/events/open-space-the-road-to-gilead/ Museum of Comedy, 13 February, 20 February, 5 March. https://www.museumofcomedy.com/the-guilty-feminist Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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464. ROAD TO GILEAD: Reform's Ties to the ADF with Susan Wokoma and special guest Jane Bradley

Becoming a Healing Presence

Play Episode Listen Later Jan 5, 2026 93:04

The Guilty Feminist 464. Reform's Ties to the ADF Presented by Deborah Frances-White and Susan Wokoma and special guest Jane Bradley. Recorded 23 November 2025 at The Bill Murray Comedy Club. Released 5 January. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Susan Wokoma https://www.instagram.com/susiewoosie12 https://www.instagram.com/p/DFK7aZDI5Sb More about Jane Bradley https://www.instagram.com/janebradleynyt https://www.nytimes.com/by/jane-bradley For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Open Space Event, 17 January. https://www.eventbrite.co.uk/e/road-to-gilead-open-space-event-tickets-1976897741361 Open Space in Basingstoke. https://www.proteustheatre.com/events/open-space-the-road-to-gilead/ Museum of Comedy, 13 February, 20 February, 5 March. https://www.museumofcomedy.com/the-guilty-feminist Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Word of the Day with Rene Holaday for Monday, 1-5-26: Micah 7:1-20

radiofreeredoubt

Play Episode Listen Later Jan 5, 2026 15:38

The Word of the Day with Rene Holaday for Monday, 1-5-26: Micah 7:1-20: "Sorrow for Israel's Sins, and God will Forgive Israel." Verse18 says: "He does not retain His anger forever, because He delights in mercy." Verse 14 describes "Shepherd Your people with Your staff. the flock of Your heritage who dwell solitarily in a woodland, in the midst of Carmel; Let them feed in Bashan and Gilead, as in the days of old." We are watching the full restoration of Israel right now, just as Micah predicts here in this chapter. Join me this morning to hear how God is a covenant God who keeps His promises and covenants. He punished Israel for crucifying The Messiah, but He is also their redeemer who brings them back and restores them to the fullest because He delights in MERCY! ;() Hurray!! If any of you can help me with firewood, I could use help! If you're blessed by this daily Bible Study and you can help me with a donation of $5 or more to my PayPal address, it certainly would be appreciated! This next couple weeks I will be having a "FIREWOOD funds drive" so I can buy more firewood, and you can donate any amount to : reneholaday@gmail.com if you go to PayPal.com and let them know your amount and my PayPal email address. THANK YOU ahead of time! Blessings to everyone! ;()

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In Every Danger There Is Opportunity

Play Episode Listen Later Jan 5, 2026

Dr. Rossi interviews a long-time friend and physician about "The Balm of Gilead" and her ministry of physical and spiritual healing in the medical field.

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Margaret Atwood, writer

Desert Island Discs

Play Episode Listen Later Jan 4, 2026 53:41

Margaret Atwood is a Canadian writer. She has published more than sixty books spanning novels, poetry, short stories, non-fiction, children's literature, and graphic novels, and has been called “one of the sharpest and most imaginative novelists writing in English”. She is one of only four writers to have won the Booker Prize twice: for The Blind Assassin in 2000 and for her 2019 follow-up to The Handmaid's Tale, The Testaments.Margaret was born in Ottawa in November 1939, shortly after the outbreak of World War II, the second of three children to Carl Atwood, an entomologist. During her early life, she would spend the warmer months in the remote forests of northern Quebec and Ontario where her father tracked insect infestations, and the winters in the city (first Ottawa, later Toronto). She didn't attend school for a full year until the age of twelve.Her childhood scribblings – a “novel” about an ant called Annie, a volume of rhyming poems about cats, and a play about a giant – turned into a more serious ambition to become a writer when Margaret was sixteen. After studying English at the University of Toronto, where she began publishing poems in the college magazine, her first novel, The Edible Woman, came out in 1969, following five collections of poetry. Her most famous work, The Handmaid's Tale, was published in 1985 and depicted a dystopian vision of the United States as a patriarchal and totalitarian place called Gilead. Although it was written during the Reagan era, it has become eerily relevant again in the wake of the election of Donald Trump. Margaret lost her life partner, the writer Graeme Gibson, in 2019. She lives in Toronto.DISC ONE: Anchors Aweigh - US Navy Band DISC TWO: Hearts of Stone - The Charms DISC THREE: Offenbach: Les contes d'Hoffmann, Giulietta Act: Barcarolle. Belle nuit, ô nuit d'amour. Performed by Joan Sutherland (soprano) Huguette Tourangeau (soprano), Plácido Domingo (tenor), Andre Neury (bass), Pro Arte Choir, Lausanne, Choeur Du Brassus, Choeur de la Radio Suisse Romande, Orchestre de la Suisse Romande, conducted by Richard Bonynge DISC FOUR: Four Strong Winds - Ian & Sylvia DISC FIVE: Barrett's Privateers - Stan Rogers DISC SIX: The Handmaid's Tale, Act I Scene 6: The Doctor. Composed by Poul Ruders and performed by Marianne Rorholm, Hanne Fischer (Mezzo-sopranos), Royal Danish Opera Chorus and Royal Danish Orchestra, conducted by Michael Schønwandt DISC SEVEN: We Praise the Tiny Perfect Moles - Orville Stoeber DISC EIGHT: Symphony No. 6 in F Major, Op. 68 "Pastoral": II. Scene am Bach. Andante molto moto. Composed by Beethoven and performed by Philharmonia Orchestra, conducted by Otto Klemperer BOOK CHOICE: How to Survive on a Desert Island by Samantha Bell LUXURY ITEM: A knife and matchbox CASTAWAY'S FAVOURITE: Hearts of Stone - The Charms Presenter: Lauren Laverne Producer: Sarah Taylor

Moral Movements Without God | Judges 20:1-7

UBM Unleavened Bread Ministries

Play Episode Listen Later Jan 4, 2026 6:20

Welcome to The Daily, where we study the Bible verse by verse, chapter by chapter, every day. Read more about Project23 and partner with us as we teach every verse of the Bible on video. Our text today is Judges 20:1-7. Then all the people of Israel came out, from Dan to Beersheba, including the land of Gilead, and the congregation assembled as one man to the Lord at Mizpah. And the chiefs of all the people, of all the tribes of Israel, presented themselves in the assembly of the people of God, 400,000 men on foot that drew the sword. (Now the people of Benjamin heard that the people of Israel had gone up to Mizpah.) And the people of Israel said, "Tell us, how did this evil happen?" And the Levite, the husband of the woman who was murdered, answered and said, "I came to Gibeah that belongs to Benjamin, I and my concubine, to spend the night. And the leaders of Gibeah rose against me and surrounded the house against me by night. They meant to kill me, and they violated my concubine, and she is dead. So I took hold of my concubine and cut her in pieces and sent her throughout all the country of the inheritance of Israel, for they have committed abomination and outrage in Israel. Behold, you people of Israel, all of you, give your advice and counsel here." — Judges 20:1-7 The scene opens with national unity—but not spiritual unity. Israel is outraged. The murder and dismemberment of the Levite's concubine shocks them into action. Four hundred thousand men march to Mizpah, ready to make war. But notice what's missing: there's no prayer, no repentance, no seeking God's will. They are united in outrage, not obedience. They are loud about the problem, but blind to their part in it. And the Levite—the one who caused this entire mess—plays the victim. He twists the story to make himself look righteous. He never admits his cowardice or cruelty. He blames everyone but himself. This is what happens when moral outrage replaces moral conviction. It feels righteous. It sounds godly. But it's hollow—because it lacks repentance. We do the same thing today. We rage against corruption in politics, immorality in culture, and sin in society—while ignoring the idols in our own homes. We tweet truth without living it. We protest evil but excuse pride. We call for justice but never kneel for mercy. The Church must beware of becoming like Israel at Mizpah—loud in anger but silent in repentance. Before we correct the world, we must first let God correct us. The greatest threat to righteousness isn't the sin of others in the world but believers with unrepentant hearts. Revival begins with us, the righteous, getting right with God. So are you ready to remove the log from your eye? "You hypocrite, first take the log out of your own eye, and then you will see clearly to take the speck out of your brother's eye." — Matthew 7:5 ASK THIS: Where have I confused moral anger with spiritual obedience? Do I seek to fix others before I allow God to confront me? How do I respond when God exposes my hypocrisy? What would it look like to start repentance before reaction this week? DO THIS: Identify one area where your outrage exceeds your obedience—and confess it. Lead your family in a moment of prayer, asking God to purify your hearts before you judge others. Replace complaining with confession; revival always starts at home. PRAY THIS: Lord, help me see the sin beneath my outrage. Break my pride before it hardens my heart. Teach me to repent before I react, and to seek Your truth before I speak mine. Amen. PLAY THIS: "Lord, I Need You."

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Taking the Promised Land - David Eells - 1.4.2026

Play Episode Listen Later Jan 4, 2026 122:01

Taking the Promised Land (1) (audio) David Eells – 1/4/26 Tsunami Coming to Flood the Land Anonymous - 07/29/2007 (David's notes in red) This is like an open vision within a dream. This was probably one of the most emotional dreams I have ever experienced so far, which is normally not the case for me. I knew God would keep me safe from the flood, but I felt the fear of God's coming wrath, which made me to tremble. I saw myself in what looked like a viewing gallery made of glass. I could see miles into the ocean. I saw huge, extremely high waves approaching the land. It approached like a tsunami and entered inland. I then heard the voice of God saying, “Go and tell David Eells these words which must be highlighted in red, Warning: Judgment is Coming”. I then saw myself in a huge hall-like sanctuary, and you were preaching. There were people from different parts of the world. I saw Christians that I knew from my nation. These people started approaching me and asking me whether I was the one who saw the “Judgment dream” as they had read about it on the Internet. They could not believe that God could speak through a nobody like me! Praise God for that! The carnal church doesn't understand why God chooses to use nobodies like us. They only respect the great and notable important ones of the worldly church. But God's power is made perfect in weakness. I saw a group of careless Christians in this sanctuary who did not believe that God would send judgment to the wicked nations. They started to walk away in different directions out of this sanctuary to go about their daily affairs, such as work. But what was so amazing was that you were running before these people, with me running alongside, and you would stand in front of their paths and block their way and speak to them the Word about God's impending judgment. You really tired me with all that running in different directions away from the sanctuary! This is our ministry, reaching out to those who have not learned to abide in the safety of Christ. But I admired your persistence. I told God I had never met a persistent preacher like you! Because of the nature of our ministry: Internet, radio and access TV, we can preach day and night, non-stop, even beyond the confines of abiding in Christ, even as we ourselves abide in Christ. I saw that you would not let anyone pass you until you warned them! I was different. I only spoke about God when people approached me about God. Some repented; however, it is sad to say there were many who refused to believe, and they wanted to go back to work instead of staying in that sanctuary. It's time for people to think more about abiding in Christ than their livelihood. If we lose our life before the time we wont need a job. We had strayed way from this sanctuary due to warning the people. We were anticipating the floods at any time. This place was full of rocks/boulders. We had to climb down a boulder, then up again to make our way to safety. Suddenly, there appeared a fair woman (she looked western) dressed in white flowing garments. (The true church of Revelation 12:1.) She was holding a fair baby swaddled in white cloth. I quickly climbed down, and she told me to take her baby because she would not make it. (The church, as it is, will be brought to spiritual death to self through the coming judgments so that it may manifest resurrection life.) That baby was sleeping in her arms peacefully. However, as she handed me that baby, she spoke to it that she would not make it, but someone else would take care of it, and then it started to cry violently. (The man-child's warning to the church of coming crucifixion.) I took that baby, which was extremely tiny. I'm single, but I'm sure babies don't come in that size! (A small body of people in comparison to the mother.) It was so tiny yet very powerful that when its head and body started to wriggle, I had difficulty holding it, and it nearly dropped out of my hands. Fortunately, the lady made it down just in time to catch hold of that baby! (In humbling themselves to the Lord, they will receive the ministry of the man-child they have previously given up.) I can't remember seeing that woman and baby at this point. Because the floods were expected to come, I entered into a huge, tall hotel built upon a rock. It could be as tall as 100 floors. (The 100-fold fruit of those who abide fully on the rock of Christ.) I have never seen such a superstructure like this before in my life. I entered that hotel, and I saw many Christians there who believed in the impending judgment of God. We wanted to change our rooms from the lower floors to the highest floors. (More heavenly, less earthly, 100 fold fruit.) The desk clerk checked and acceded to our request because the highest floors were all vacant. He said that it would cost $89 per person. (The Lord sent me to Matthew 13 when I read this, and immediately showed me the 8th and 9th verse. Mat.13:8 and others fell upon the good ground, and yielded fruit, some a hundredfold, some sixty, some thirty. 9 He that hath ears, let him hear. Also Psa.89 brings us to the Man-child.) My sister prepaid for all of these Christian families with her credit card. The Christian families told my sister that they would settle the bill for their share of the hotel fees. (We have heavenly credit because of the sacrifice of Jesus but also we have to count the cost of losing our life in this world to have our heavenly life.) The dream ended here. I have been having visits of fallen angels recently. I can sometimes see them with my naked eyes! I just had a visit last Tuesday. I would just rebuke them in Jesus name and they would dissipate immediately from view. I wonder why? (To show we have authority over them in Jesus' name.) Spoken to me: Floods/tsunamis spiritually speak of judgments. I believe you are reaching many nations through your ministry. Your ministry is primarily preparing people to escape the coming tribulation. God is no respecter of persons, and He can speak through whom He chooses. I believe that the coming judgment is around the corner, maybe sooner than some may conceive. As usual, there will be those who are just careless in their Christian life, and like in Noah's time, they want to eat, drink, marry, and go about their daily routine until it is too late for them to repent of their folly. I believe the lady speaks about the church, and the baby speaks of the man-child. Promised Land or Beast Land? Father sent me five words given to the saints at the same time, which He showed me are related. A Detention Camp D.L. - 06/18/2013 (David's notes in red) On January 12, 1994, I had a dream in which the Lord told me to go and anoint a detention camp. (His name means “world ruler”, which probably represents the Man-child who anoints the camp. The camp represents that Beast bondage is coming to God's people, apparently for their good.) It was to be a place where many Christians would suffer in their bodies, putting an end to sin 1Pe.4:1 Forasmuch then as Christ suffered in the flesh, arm ye yourselves also with the same mind; for he that hath suffered in the flesh hath ceased from sin; 2 that ye no longer should live the rest of your time in flesh to the lusts of men, but to the will of God. After anointing the camp, I was to run away as fast as I could. The only part I saw in the dream was me looking down upon myself running down a path or road as fast as I could. So I have no idea what the camp looked like or where in the camp I did the anointing. (This is a worldwide camp of beast bondage anointed and ordained to bring repentance and purity to God's people.) Note: There is a warning here for Christians to get their lives in order before the Lord, so they can enjoy the Lord's protection for whatever dangers there are in the future and avoid, if possible, places like this. (You can escape through holiness.) Deb Horton - 06/16/2013 For the past few days, I kept getting repeated in my mind this phrase: “for I watch over my word to perform it”. But I didn't know it was for UBM. Sorry! (I told Care about it on Friday, so I have a witness.) This phrase is from Jer.1:12 Then said the Lord unto me, Thou hast well seen: for I watch over my word to perform it. (What Word will the Father watch over to perform? How and why will He do this?) (Below is the text and some interpretation.) Jer.1:1 The words of Jeremiah the son of Hilkiah, of the priests that were in Anathoth in the land of Benjamin: 2 to whom the word of Jehovah came in the days of Josiah the son of Amon, king of Judah, in the thirteenth year of his reign. 3 It came also in the days of Jehoiakim the son of Josiah, king of Judah, unto the end of the eleventh year of Zedekiah, the son of Josiah, king of Judah, unto the carrying away of Jerusalem captive in the fifth month. (As we see, this will be the carrying away unto the Beast captivity of God's apostate people.) 4 Now the word of Jehovah came unto me, saying, 5 Before I formed thee in the belly I knew thee, and before thou camest forth out of the womb I sanctified thee; I have appointed thee a prophet unto the nations. 6 Then said I, Ah, Lord Jehovah! behold, I know not how to speak; for I am a child. 7 But Jehovah said unto me, Say not, I am a child; for to whomsoever I shall send thee thou shalt go, and whatsoever I shall command thee thou shalt speak. (This is the same conversation God had with Moses the Man-child. Jeremiah represents the Man-child who basically said he didn't know how to speak, and God said, “Fear not. I will speak through you”.) 8 Be not afraid because of them; for I am with thee to deliver thee, saith Jehovah. 9 Then Jehovah put forth his hand, and touched my mouth; and Jehovah said unto me, Behold, I have put my words in thy mouth: (To release a sword against God's people to bring them to repentance.) 10 see, I have this day set thee over the nations and over the kingdoms, to pluck up and to break down and to destroy and to overthrow, to build and to plant. 1011 (the gematria for the Man-child) Moreover the word of Jehovah came unto me, saying, Jeremiah, what seest thou? And I said, I see a rod (the “rod of my son” - Ezekiel 21:10 below) of an almond-tree (almonds are first-fruits). Here is Ezekiel 21:10 in context: Eze.21:8 And the word of Jehovah came unto me, saying, 9 Son of man (Jesus manifested in His Man-child body), prophesy, and say, Thus saith Jehovah: Say, A sword, a sword, it is sharpened, and also furbished; 10 it is sharpened that it may make a slaughter; it is furbished that it may be as lightning: shall we then make mirth? the rod of my son, it contemneth every tree (The rod of God's Son will speak judgment on God's people through the Man-child who speaks not for “Churchianity” but God.). 11(again) And it is given to be furbished, that it may be handled: the sword, it is sharpened, yea, it is furbished, to give it into the hand of the slayer. (Authority given to the Beast to slay the flesh of God's rebellious people.) 12 Cry and wail, son of man; for it is upon my people, it is upon all the princes of Israel: they are delivered over to the sword with my people; smite therefore upon thy thigh. 13 For there is a trial (or tribulation); and what if even the rod that contemneth shall be no more? saith the Lord Jehovah. (If the rod of the Lord's son was not there to chasten them, they would be lost. We must lose our life to gain our higher life.) 14 Thou therefore, son of man, prophesy, and smite thy hands together; and let the sword be doubled the third time (Third world kingdom to conquer God's people; there was Egypt, Assyria, and third was Babylon. Likewise, World Wars I and II brought New World Orders, the League of Nations and the United Nations, and WW III will bring the tribulation Dragon of Revelation 12. This third time, a sword will come against God's rebellious leadership and people.), the sword of the deadly wounded: it is the sword of the great one that is deadly wounded, which entereth into their chambers. 15 I have set the threatening sword against all their gates, that their heart may melt, and their stumblings be multiplied: ah! it is made as lightning, it is pointed for slaughter (God chastens every son that He receives; a humbling is coming.). Back to our Jeremiah text. Jer.1:12 Then said Jehovah unto me, Thou hast well seen: for I watch over my word to perform it. (According to God's will, the Beast will once again make war on the saints to bring them to their cross.) 13 And the word of Jehovah came unto me the second time, saying, What seest thou? And I said, I see a boiling caldron; and the face thereof is from the north (the Beast from the north makes war against God's people). 14 Then Jehovah said unto me, Out of the north evil shall break forth upon all the inhabitants of the land. 15 For, lo, I will call all the families of the kingdoms of the north (the seven-headed Beast kingdom), saith Jehovah; and they shall come, and they shall set every one his throne at the entrance of the gates of Jerusalem (the apostate leadership of God's people today), and against all the walls thereof round about, and against all the cities of Judah. 16 And I will utter my judgments against them touching all their wickedness, in that they have forsaken me, and have burned incense unto other gods (Elohim), and worshipped the works of their own hands (religions, doctrines, church buildings, of men). 17 Thou therefore gird up thy loins, and arise, and speak unto them all that I command thee: be not dismayed at them, lest I dismay thee before them. (i.e. The Lord was saying, “Man-child, be strengthened to do battle against the apostates. Pay no attention to their disapproval; just speak what I say”.) 18 For, behold, I have made thee this day a fortified city, and an iron pillar, and brazen walls, against the whole land, against the kings of Judah, against the princes thereof, against the priests thereof, and against the people of the land. (As it was when Jesus was strengthened to come against the entrenched Pharisees who warred against Him. And I received this same treatment for myself and got these same verses.) 19 And they shall fight against thee; but they shall not prevail against thee: for I am with thee, saith Jehovah, to deliver thee. (I received this same text when called on the carpet by an old order religion I was asked to speak at.) So what do we do? M. L. received this word this morning: Neh.9:2 And the seed of Israel separated themselves (sanctified themselves) from all foreigners (This separation is happening. Those who act foreign to God's Kingdom are.), and stood and confessed their sins, and the iniquities of their fathers (Confession of sins always brings the grace of God in deliverance and healing.). 3 And they stood up in their place, and read in the book of the law of Jehovah their God a fourth part of the day (humility to the Word brings mercy); and [another] fourth part they confessed, and worshipped Jehovah their God. So they confessed their sins of their fathers which they had inherited through the blood for “the life of the flesh is in the blood”: 13 Thou camest down also upon mount Sinai, and spakest with them from heaven, and gavest them right ordinances and true laws, good statutes and Commandments (He gave us His Word), 14 and madest known unto them thy holy sabbath (His rest through faith), and commandedst them commandments, and statutes, and a law, by Moses thy servant (a Man-child type), 15 and gavest them bread from heaven for their hunger, and broughtest forth water for them out of the rock for their thirst, and commandedst them that they should go in to possess the land (or take dominion over the flesh) which thou hadst sworn to give them. (They rebelled and left the old man ruling the land.) 16 But they and our fathers dealt proudly and hardened their neck, and hearkened not to thy commandments, 17 and refused to obey, neither were mindful of thy wonders that thou didst among them, but hardened their neck, and in their rebellion appointed a captain to return to their bondage (A factious leader, for they loved the fleshpots of Egypt where they were ruled over and fed by the carnal man). But thou art a God ready to pardon, gracious and merciful, slow to anger, and abundant in lovingkindness, and forsookest them not. 18 Yea, when they had made them a molten calf, and said, This is thy God that brought thee up out of Egypt, and had wrought great provocations (So they made their own Jesus after their own likeness who smiled upon their sinful lives.); 19 yet thou in thy manifold mercies forsookest them not in the wilderness: the pillar of cloud departed not from over them by day, to lead them in the way; neither the pillar of fire by night, to show them light, and the way wherein they should go. And they confessed their sins: 26 Nevertheless they were disobedient, and rebelled against thee, and cast thy law behind their back (they ignored the Word, as today), and slew thy prophets that testified against them to turn them again unto thee, and they wrought great provocations. (They weren't satisfied to just walk away when they rebelled against the Word of God; they had to silence the Word at all costs; they had to kill the men who sacrificed their lives to bring them the Word. At the same time as receiving this word, M. L. received Psalm 55:12-19 about this, and closed her Bible because she was tired of hearing this. She asked for another word and opened her Bible and put her finger down on the same verse. Psa.55:12 For it was not an enemy that reproached me; Then I could have borne it: Neither was it he that hated me that did magnify himself against me; Then I would have hid myself from him: 13 But it was thou, a man mine equal, My companion, and my familiar friend. 14 We took sweet counsel together; We walked in the house of God with the throng. 15 Let death come suddenly upon them, Let them go down alive into Sheol; For wickedness is in their dwelling, in the midst of them. 16 As for me, I will call upon God; And Jehovah will save me. 17 Evening, and morning, and at noonday, will I complain, and moan; And he will hear my voice. 18 He hath redeemed my soul in peace from the battle that was against me; For they were many [that strove] with me. 19 God will hear, and answer them, Even he that abideth of old, Selah [The men] who have no changes, And who fear not God. 20 He hath put forth his hands against such as were at peace with him: He hath profaned his covenant. 21 His mouth was smooth as butter, But his heart was war: His words were softer than oil, Yet were they drawn swords. 22 Cast thy burden upon Jehovah, and he will sustain thee: He will never suffer the righteous to be moved. 23 But thou, O God, wilt bring them down into the pit of destruction: Bloodthirsty and deceitful men shall not live out half their days; But I will trust in thee.) Because of this great provocation: 27 Therefore thou deliveredst them into the hand of their adversaries, who distressed them: and in the time of their trouble, when they cried unto thee, thou heardest from heaven; and according to thy manifold mercies thou gavest them saviours who saved them out of the hand of their adversaries. 28 But after they had rest, they did evil again before thee; therefore leftest thou them in the hand of their enemies, so that they had the dominion over them: yet when they returned, and cried unto thee, thou heardest from heaven; and many times didst thou deliver them according to thy mercies, 29 and testifiedst against them, that thou mightest bring them again unto thy law. Yet they dealt proudly, and hearkened not unto thy commandments, but sinned against thine ordinances, (which if a man do, he shall live in them,) and withdrew the shoulder, and hardened their neck, and would not hear. 30 Yet many years didst thou bear with them, and testifiedst against them by thy Spirit through thy prophets: yet would they not give ear: therefore gavest thou them into the hand of the peoples of the lands (to be ruled over and oppressed by the Beast). So what do we do to have God's blessing and come out from under the curse? We walk in the light of God's Word. On 6/16/13 a sister received Eze.47:21 So shall ye divide this land unto you according to the tribes of Israel. But she sent this whole text, which shows us how to possess the Promised Land of rest, milk, and honey: Eze.47:1 And he brought me back unto the door of the house; and, behold, waters issued out from under the threshold of the house eastward (for the forefront of the house was toward the east); and the waters came down from under, from the right side of the house, on the south of the altar. (The Word is the waters from the House of God to bring salvation and healing to the peoples.) 2 Then he brought me out by the way of the gate northward, and led me round by the way without unto the outer gate, by the way of the gate that looketh toward the east; and, behold, there ran out waters on the right side. 3 When the man went forth eastward with the line in his hand, he measured a thousand cubits, and he caused me to pass through the waters, waters that were to the ankles. (What is the depth of the Word you walk in?) 4 Again he measured a thousand, and caused me to pass through the waters, waters that were to the knees. (30-fold fruit of the waters walked in) Again he measured a thousand, and caused me to pass through the waters, waters that were to the loins. (60-fold fruit of the waters walked in) 5 Afterward he measured a thousand; and it was a river that I could not pass through; for the waters were risen, waters to swim in, a river that could not be passed through. (Waters of baptism go over the head to put to death the mind of flesh. 100-fold fruit of the waters walked in.) 6 And he said unto me, Son of man (the Man-child walking in 100-fold fruit), hast thou seen this? Then he brought me, and caused me to return to the bank of the river. 7 Now when I had returned, behold, upon the bank of the river were very many trees on the one side and on the other. (Those witnesses who bring the healing waters of the tongue to the peoples, as below. And as Jesus the Man-child witnesses did.) 8 Then said he unto me, These waters issue forth toward the eastern region, and shall go down into the Arabah; and they shall go toward the sea (the Dead Sea, representing the dead peoples of the world); into the sea shall the waters go which were made to issue forth; and the waters shall be healed. 9 And it shall come to pass, that every living creature which swarmeth, in every place whither the rivers come, shall live (a great revival of the Word coming when many church people reject it.); and there shall be a very great multitude of fish; for these waters are come thither, and the waters of the sea shall be healed (The word and understanding of lost people shall be cleansed), and everything shall live whithersoever the river cometh. (Out of your innermost being shall flow rivers of living waters -- John 7:38.) 10 And it shall come to pass, that fishers shall stand by it: from En-gedi even unto En-eglaim shall be a place for the spreading of nets; their fish shall be after their kinds, as the fish of the great sea, exceeding many. (many evangelists will fish for them) 11 But the miry places thereof, and the marshes thereof, shall not be healed; they shall be given up to salt. (Living waters are moving waters; dead waters are stagnant waters, as the Pharisees walk in. They will be reprobated, like Lot's wife, who turned to salt when she looked back.) 12 And by the river upon the bank thereof, on this side and on that side, shall grow every tree for food, whose leaf shall not whither, neither shall the fruit thereof fail: it shall bring forth new fruit every month, because the waters thereof issue out of the sanctuary; and the fruit thereof shall be for food, and the leaf thereof for healing. (As Revelation 22 shows, the waters give life to the trees whose leaves are for the healing of the nations.) Rev.22:1 And he showed me a river of water of life, bright as crystal, proceeding out of the throne of God and of the Lamb, (Only the living Word can do this) 2 in the midst of the street thereof. And on this side of the river and on that was the tree of life (Pro.15:4 The healing of the tongue is a tree of life... In Hebrew), bearing twelve [manner of] fruits, yielding its fruit every month: and the leaves of the tree were for the healing of the nations. 3 And there shall be no curse any more (the waters of the Word are to deliver us from the curse): and the throne of God and of the Lamb shall be therein: and his servants shall serve him; 4 and they shall see his face; and his name [shall be] on their foreheads. 5 And there shall be night no more; and they need no light of lamp, neither light of sun; for the Lord God shall give them light (if we walk in the light as He is in the light): and they shall reign for ever and ever. 6 And he said unto me, These words are faithful and true: and the Lord, the God of the spirits of the prophets, sent his angels to show unto his servants the things which must shortly come to pass. If we walk in the light of the water of the Word, we will be blessed to take the land of rest, God's promised land of milk and honey. If we continue to rebel against the Word, we shall see a terrible beast bondage. Now back to Ezekiel text: 13 Thus saith the Lord Jehovah: This shall be the border, whereby ye shall divide the land for inheritance according to the twelve tribes of Israel: Joseph shall have two portions. (The land is divided among the 12 tribes [verse 21] by lot [in verse 22]. We are the spiritual 12 tribes. (1Co 10:11) Now these things happened unto them by way of example [Greek: figure or type]; and they were written for our admonition, upon whom the ends of the ages are come.) 14 And ye shall inherit it, one as well as another; for I sware to give it unto your fathers: and this land shall fall unto you for inheritance. (The promises are our Promised Land of rest from our enemies.) 15 And this shall be the border of the land: On the north side, from the great sea, by the way of Hethlon, unto the entrance of Zedad; 16 Hamath, Berothah, Sibraim, which is between the border of Damascus and the border of Hamath; Hazer-hatticon, which is by the border of Hauran. 17 And the border from the sea, shall be Hazar-enon at the border of Damascus; and on the north northward is the border of Hamath. This is the north side. 18 And the east side, between Hauran and Damascus and Gilead, and the land of Israel, shall be the Jordan; from the north border unto the east sea shall ye measure. This is the east side. 19 And the south side southward shall be from Tamar as far as the waters of Meriboth-kadesh, to the brook of Egypt, unto the great sea. This is the south side southward. 20 And the west side shall be the great sea, from the south border as far as over against the entrance of Hamath. This is the west side. 21 So shall ye divide this land unto you according to the tribes of Israel. 22 And it shall come to pass, that ye shall divide it by lot for an inheritance unto you and to the strangers that sojourn among you, who shall beget children among you; and they shall be unto you as the home-born among the children of Israel; they shall have inheritance with you among the tribes of Israel. (These strangers could well be your lost loved ones who you are believing for and will inherit the land with you.) 23 And it shall come to pass, that in what tribe the stranger sojourneth, there shall ye give him his inheritance, saith the Lord Jehovah. When I finished the above, I received this note: Anonymous - 06/19/2013 The broader church is about to go into the captivity of the Beast system to separate the wheat from the tares: Psa.53:6 Oh that the salvation of Israel were come out of Zion! When God bringeth back the captivity of his people, Then shall Jacob rejoice, and Israel shall be glad. The Man-child among us will lead the way out of spiritual captivity: 54:1 For the Chief Musician; on stringed instruments. Maschil of David; when the Ziphites came and said to Saul Doth not David hide himself with us? Save me, O God, by thy name, And judge me in thy might. Pray fervently! 2 Hear my prayer, O God; Give ear to the words of my mouth. The factious will again rise up through the tribulation: 3 For strangers are risen up against me, And violent men have sought after my soul: They have not set God before them. The Word sanctifies the soul: 4 Behold, God is my helper: The Lord is of them that uphold my soul. The Word will overcome for us and through us: 5 He will requite the evil unto mine enemies: Destroy thou them in thy truth. The “name” (nature, character and authority) of the Lord brings the “living sacrifice!” 6 With a freewill-offering will I sacrifice unto thee: I will give thanks unto thy name, O Jehovah, for it is good. Which brings the deliverance from the spiritual hosts of wickedness in the heavenly places: 7 For he hath delivered me out of all trouble; And mine eye hath seen my desire upon mine enemies. The Promised Land is not for Enemies These dreams are similar to those we have received in the past, which speak of fear moving people out of the area, in this case by train, which would only be necessary if the fault lines to the east and west opened up and main highways were cut off as we have dreamed. And then repositioning us in the area in preparation for many more Christians to come. Moving and Trains Sandy Shaw - 08/22/2015 (David's notes in red) In a dream, a sister was talking to me, saying, “Everyone in the circle is moving”. (This means the local UBM circle. I asked the Lord if we were all moving and got three heads for YES.) I asked, “How does everyone feel about that?” She said, “We are ready to go; we are at peace with the idea”. (A word received for this dream: Isa.26:3 Thou wilt keep him in perfect peace, whose mind is stayed on thee; because he trusteth in thee.) (M. L. had a dream called “Getting Ready” on 6/16/15, which is about them being in a large house, rather than the mobile home they are now in and getting it ready because all their children and grandchildren were coming. The coming children could have a spiritual meaning, as well as a physical meaning. Many children are coming. Michael L. dreamed that UBM people were moving into housing close together, which is outside the city. Bill had a dream we were there, too. M. L. had a dream that I was moving into an office there, too. We have always known that our housing is temporary at first and we are all renting. Housing has been provided.) Then, from the Walmart parking lot, I saw the following: A train, a document on special paper, and chaos and fear here in the local area, but we were at peace. (Walmart stores are reported to be staging areas to separate the Christians and, according to Eve's dream, a place where some may never be seen again. The fear represents the hornet of fear that drives the inhabitants from the Promised Land ahead of God's chosen. Pray for God's people among them! We do not make God's plans; we merely obey them.) I could not see the message on the document. Then I saw a man's hand as he pointed at it. He shouted, “Can't you see it?” He asked three times and continued to point, “It's right there!” (Could it be that the earthquakes have happened, and as seen before, the faults cut off the interstate and main road, leaving the area. The hornet of fear will drive people from our Promised Land. A false warning from geologists that the peninsula could sink into the waters that have filled in the faults?) I asked in frustration, “Lord, why can't I see it?” (Because Sandy doesn't hear the message of fear, she is not going with them. In one of her recent dreams, she was hidden in Christ, in the underground, when the people were leaving.) Then T. C. popped up with outstretched arms. She said, “Sandy, you know God is sovereign. He will reveal it to you when He is ready”. (In other words, He will reveal what you need to know on a need-to-know basis.) Sandy said, “I see a train that is not moving (I asked Sandy if this could be the train we are used to seeing. The only one that goes north and south through the valley. She thought so.), but I hear a train that is moving (the people out). Then the feeling of dread, like oh, no, came over me”. (I asked her if the moving train could be a passenger train and she said she felt it was. It is a possibility that this train could represent a train of cars leaving town. You can't get many people on a normal passenger train, but of course, the Nazis moved the Jews in boxcars. Then again, if they are going to a FEMA camp, they may not take their cars, and if the interstate and main highway are taken out, possibly the train is the only way out of the area. That way, they couldn't take much with them, which is what was already revealed to us. Sandy's dream of all the people walking or riding bikes to this central city [trains] while she ducked into the woods with others to a hiding place underground could be a clue. They wouldn't need their cars if they were boarding a train. But they may not know they are not coming back.) Amazing words by faith at random this same morning: This morning, Michael L. got Ezr.2:70 So the priests, and the Levites, and some of the people, and the singers, and the porters, and the Nethinim, dwelt in their cities, and all Israel in their cities. 3:1 And when the seventh month (on the Hebrew Biblical calendar, this is September) was come, and the children of Israel were in the cities, the people gathered themselves together as one man to Jerusalem. We used to talk about our Jerusalem in this area. The Man-child David and his men took Jerusalem after he was anointed. Notice the same amazing words in the next verse. Also, this morning B. A. got Ezr.10:9 Then all the men of Judah and Benjamin gathered themselves together unto Jerusalem within the three days; it was the ninth month, on the twentieth day of the month: and all the people sat in the broad place before the house of God, trembling because of this matter, and for the great rain. (The outpouring of God's Spirit?) P. O. asked the Father for a verse to share. She said, “I felt led to ask Him for a verse that we needed to hear. He put my finger down on Isa.54:1 Sing, O sing ye barren... The whole chapter seemed appropriate. Then I felt like singing. The song that came out of the blue was Christ Arose”. Low in the grave He lay; Jesus my Savior; Waiting the coming day, Jesus Our Lord. Up from the grave He arose, with a mighty triumph over His foes. He arose a victor from the dark domain, And He lives forever with His saints to reign! Many People Coming to UBM M. L.- 08/21/2015 It was a sunny day with blue sky and an atmosphere of rejoicing. People, people everywhere. Where did they all come from? How did they get here? How did they find us? What is their story? My dream opened up at seeing hundreds and hundreds of people coming to us. And I saw some more in the distance coming toward us, too. (This could be the call to go into the wilderness after the earthquakes and Man-child anointing. Those in the distance are those coming later.) I saw quick glances of people like snapshots seated at makeshift tables. More in the foreground were small, white, round tables; it seemed four could sit at each. At a section of white table, close to my observation point, there was a woman who caught my attention. She had finished eating and had kept looking to the right. She had blond hair that was long and was brought from her face to the sides in a becoming way. Her face was radiant as she watched the people about her. She looked familiar but she was different, taller, lighter hair. She will return and she will show radiance, too. (We knew this woman as a righteous woman but she was deceived into the faction by her husband. We had dreams this would happen to her but we also have had dreams she would return very humbled but without her husband who would die. So we think she is a type of many who will repent and return as the Lord has said to us.) This was all outside and people were eating. Everyone had a plate and something to drink. Believe it or not, the food just appeared as people were waiting in line. (Jesus, as a type of the end time Man-child in whom He lives by His Word and Spirit, multiplied the food in the wilderness.) Rectangular bountiful tables were end upon end and row upon row, just to hold the food. The people were patient and kind and loving to one another. (The only kind of people who will escape the Beast.) I saw close-up shots of lasagna being put on a plate. Crispy chicken, salad, greens, biscuits and on and on. The food dishes were replaced as the last piece or spoonful was taken. Where did it come from? I saw no one carrying food to the table. (Manna comes out of heaven.) Since we were outside, where were the ovens that baked everything? I knew our local body was serving but never really saw anyone. It was a busy time and we were servants to all. (A Marriage Feast in the wilderness.) I didn't see any buildings nor could I see if we were in a field or a grassy area because I saw everything from a table-height up. The edges were also blurred slightly, as I took in the scene before me. In the area, I saw no debris from damaged buildings (which will be needed). When people had finished eating, they talked excitedly and were patiently waiting for the meeting to start. This had to be on a raised area so people could see who was speaking. Then again, I didn't see this but just knew that the area on the right was where things were set up. People were looking in that direction. It was then that I noticed the people sitting at the white tables who were close to me had a special glow on their faces. Their faces had a sheen like oil on them that went into their hair. There were dozens of these tables. Then I saw more and more with the glow. (Those who manifested the glory of God by seeing Jesus in the mirror, the Gospel. 2Co.3:18 But we all, with unveiled face beholding as in a mirror the glory of the Lord, are transformed into the same image from glory to glory, even as from the Lord the Spirit.) They had come here. They had been revived by rest and food. Now they were anticipating the spiritual food for their souls, they had hungered and thirsted for so long. (Jesus, as a type of the end-time Man-child in whom He lives by His Word and Spirit, fed that food for the soul in the wilderness, too. Oh, come, Lord Jesus; we need You.) Some applicable verses: Mat.11:28 Come unto me, all ye that labor and are heavy laden, and I will give you rest. 29 Take my yoke upon you, and learn of me; for I am meek and lowly in heart: and ye shall find rest unto your souls. 30 For my yoke is easy, and my burden is light. Php.4:19 And my God shall supply every need of yours according to his riches in glory in Christ Jesus. Luk.9:12 And the day began to wear away; and the twelve came, and said unto him, Send the multitude away, that they may go into the villages and country round about, and lodge, and get provisions: for we are here in a desert place. 13 But he said unto them, Give ye them to eat. And they said, We have no more than five loaves and two fishes; except we should go and buy food for all this people. 14 For they were about five thousand men. (Not including the women and children.) And he said unto his disciples, Make them sit down in companies, about fifty each. 15 And they did so, and made them all sit down. 16 And he took the five loaves and the two fishes, and looking up to heaven, he blessed them, and brake; and gave to the disciples to set before the multitude. 17 And they ate, and were all filled: and there was taken up that which remained over to them of broken pieces, twelve baskets. (We have seen food multiplied.) Gal.5:22 But the fruit of the Spirit is love, joy, peace, longsuffering, kindness, goodness, faithfulness.... Mar.9:35 And he sat down, and called the twelve; and he saith unto them, If any man would be first, he shall be last of all, and servant of all. Exo.34:35 And the children of Israel saw the face of Moses, that the skin of Moses face shone: and Moses put the veil upon his face again, until he went in to speak with him. Psa.34:5 They looked unto him, and were radiant; and their faces shall never be confounded. 42:1 As the Deer Pants for the Water, So panteth my soul after thee, O God.... Are You Ready? Here They Come! Sandy Shaw - 08/26/2015 (David's notes in red) In a dream, I saw huge wooden double doors that were several inches thick. They had hinges and handles like those of an old castle. On the inside, there was a large, thick wooden arm that was down to bar the doors. Local UBM was inside, hurrying to get final preparations done. Everyone knew what they were to do, and they did it. There was a man at the doors. Then the wooden arm was raised up, and he shouted, “Get ready, get ready, get ready!” Then he opened the doors and shouted, “R-E-A-D-Y!” And there were hundreds and hundreds of people coming inside! A Nation of Refugees Moving Toward God Michael L. - 09/07/2015 (David's notes is red) I was on top of a mountain. It was mostly grassy, but the elevation looked to be 4,000 to 5,000 feet. I could see for many miles. It appeared as though this mountain was higher, as it allowed me to look over to the other mountains that were lower. I also saw thousands of people walking across the lands. They were traveling from left to right. (Jesus put the goats on the left and the sheep on the right, so this means to go from rebellion to submission, from goats to sheep.) None of them was saying anything. They seemed very sober or maybe tired. (The U.S. will be a nation full of refugees seeking help from God, Who will answer miraculously.) They were carrying things that they could easily handle. (It will be a wilderness experience for God's people. Many will come to know Him. When they do, He will give them a place of rest. Abraham was a sojourner: “he looked for the city which hath the foundations, whose builder and maker is God”. He searched out his Promised Land.) After seeing this, I thought that I should take my car, as it might make it easier (it was possibly a green 1960s Chevy Impala). I looked everywhere for some kind of road to travel down the mountain, but I couldn't find one. (No road down means you should stay on top of the mountain, close to God. Don't take the Chevy; it's a goat that only goes to the left.) Chevy is from French, German (Swiss) origins from chèvre meaning “goat” and, if you use the full name Chevrolet, we get lait meaning “milk”, possibly meaning for the immature. An impala is a reddish-brown African antelope with long, curved horns in the male, and is known for its ability to leap. They are food for the lion or beast. God's Promise of Protection and Provision B. A. - 01/01/2012 (David's notes is red) I dreamed I was sitting in my den with my Bible in my lap and my laptop computer open to my concordance; I often study this way. Suddenly, from the view of the west window in the den, I saw a big black Hummer vehicle pull up right outside the window. I saw five men dressed in military clothing get out of the vehicle; I could see that one of them was a high-ranking officer. My husband was standing in the kitchen between the refrigerator and the island. I stood up out of my chair and told him not to move or speak, no matter what happened. I then began to pray this prayer: “Heavenly Father, please make everything in this house invisible except me, these two chairs in the den and the table, the mattress, blankets and pillows on the floor, and the four slices of bread and two small potatoes in the cupboard. Father, please make our enemies be at peace with us, and please make our enemies bless us. Thank you, Lord. Amen.” As I finished my prayer, the officer approached the sliding glass door to the den and entered the room. He looked straight at me, then, without saying a word, he began to search the house. What happened next was amazing. The officer began to walk into the kitchen between the refrigerator and the island where my husband was standing; the officer passed right through my husband and proceeded into the dining room and all of the other rooms on that side of the house. Then, the officer came back into the kitchen and opened the cupboard, and saw the four slices of bread and two potatoes. He gently closed the cupboard doors and walked over to the sliding glass door and opened the door. In a strange language I had never heard before, he commanded one of the young men to retrieve a large sack from the front seat of the Hummer. I was actually able to understand what the officer said to this man. The young man got the sack and brought it to the officer. The officer then came back into the house and placed the sack on the counter in the kitchen, and then went back outside. Then the officer reached inside the Hummer and had something in his hand as he walked over to the west window; he placed something that looked like a seal across the window, then got back into the Hummer and left. All of this transpired without one word being spoken. I then looked back at my husband, and I was amazed at what I saw. His hair, which was sandy blond before, was now snow white. I asked him, “Do you understand what just happened?” He looked at me and fell to his knees in sobbing tears, and he cried out to the Lord to forgive him for his sins. After a while, he got up, and we discussed what all had taken place. I then asked my husband to pour out the contents of the sack onto the counter. The sack contained two bottles of water, two apples and a large bag of peanuts still in the shell. My husband then said to me, “Everything you prayed for in your prayer was granted by the Lord”. We then sang and praised the Lord together. We then went outside to see more clearly what was on this seal that was placed on the window. There was writing in a foreign language, but I was able to read and understand it as it read, “This house is clean”. I looked up the driveway and could see that there was another one of these seals on the gate at the front of the driveway, so we went up to the gate to take a closer look at that seal; this seal read, “This property has been inspected and is clean. No further inspections required”. Then I awoke from the dream. I got up from bed and just sat for hours thinking about this dream. Tears of joy ran down my face, as I believe the Lord was reassuring me that all would be well with my family and me; just believe. Mar.11:23 Verily I say unto you, Whosoever shall say unto this mountain, Be thou taken up and cast into the sea; and shall not doubt in his heart, but shall believe that what he saith cometh to pass; he shall have it. 24 Therefore I say unto you, All things whatsoever ye pray and ask for, believe that ye receive them, and ye shall have them. The Righteous Remain in the Land M. Y. - 12/05/2012 (David's notes in red) Background note: We know there is a spiritual Promised Land of our lives, which is taken possession of as the old man is conquered by the sword or Word of the spiritual man who then rules this life. However, this dream has a special and more physical meaning to the brethren involved with it because we are in a LAND that was promised to us and others by the Lord, and He has told us that only the righteous will remain. The testings of the Lord and the temptations of self, have proven some people unworthy to remain in the Refuge Land, and they are being removed, just like in this dream. We have heard this warning many times and received some of the verses below from the Lord before. In my dream, a group of people were lying down in an open area and I was lying on my side. I saw (what I thought was in the spirit) an image of me with my right arm ripped almost entirely off my shoulder and barely hanging on by a piece of flesh or muscle. I was told that if I lay that way (on my side), I would not be protected from the strong wind and the result would be damage to my arm. (The strong wind is the tribulations to come and the arm represents the works of the Christian that will not survive the trial unless they overcome. In other words, their works will fail to be works of faith. Mat.7:24 Every one therefore that heareth these words of mine, and doeth them, shall be likened unto a wise man, who built his house upon the rock: 25 and the rain descended, and the floods came, and the winds blew, and beat upon that house; and if fell not: for it was founded upon the rock [of rest in the promises]. 26 And every one that heareth these words of mine, and doeth them not, shall be likened unto a foolish man, who built his house upon the sand: 27 and the rain descended, and the floods came, and the winds blew, and smote upon that house; and it fell: and great was the fall thereof. Another way of saying this is their works were burned up in the fiery trial. 1Co.3:11 For other foundation can no man lay than that which is laid, which is Jesus Christ. 12 But if any man buildeth on the foundation gold, silver, costly stones, wood, hay, stubble [the dark man]; 13 each man's work shall be made manifest: for the day shall declare it, because it is revealed in fire; and the fire itself shall prove each man's work of what sort it is. 14 If any man's work shall abide which he built thereon, he shall receive a reward. 15 If any man's work shall be burned, he shall suffer loss: but he himself shall be saved; yet so as through fire. (He will continue in the fire for the flesh to be burned up.) I was then instructed (in the spirit or in my mind) on how to lie properly and in what direction to lie my head to avoid any damage. I practiced this a few times and knew that I had to remember it. I had to lie flat with all my members against the ground. (In other words, we have to have all of our works [arms], walk [legs], head [mind] and torso [heart] resting from our own works through faith in the promises.) I had to keep my eyes away from the wind. (In other words, get your eyes off the problem and on the Lord.) There was a black or dark man lying to my left when I held up my hand toward him in the shape of or forming the letter C. (The Christian is trying to teach the dark man who walks in darkness how to survive the coming curse. This dark man represents either the flesh or others who walk in it.) I thought that the C was a type of sign language, or I was telling myself to “see”. (Or it could also mean that we must keep our eyes away from the problem or curse and put them on C for Christ.) As I lay there in the shape I was shown, with one hand I began to pat each part of my body, as if to verify its position or to draw attention to it for instruction (to the dark man). At some point, there were no other people around, and I started wondering what would cause the strong wind. (Notice that the dark man was taken away. This is what the wind and fire do.) I considered a nuclear blast or other disasters that would cause a strong wind. I awoke and had the strong feeling that the C-shape made with my hand was telling me to see or pay attention. (The strong wind is any trial that tempts us to get into our own works and so fail to stay in the rest of faith that saves us.) When we heard this dream, there were three other people in the room with me, and I asked them to get a Word from the Lord by faith concerning this wind and what it would do by opening their Bible randomly and putting their fingers down. I was first to find a verse. Pro.2:21 For the upright shall dwell in the land, And the perfect shall remain in it. 22 But the wicked shall be cut off from the land, And the treacherous shall be rooted out of it. Notice those who are in the rest of faith will remain in the Promised Land. But, just as in the dream, the dark man is gone. This land that all four of us are in and has been promised to us is the Boat/Ark/Refuge, etc. M. Y.'s wife, got Psalm 73, which is all about the end of the wicked and survival of the righteous. Psa.73:18 Surely thou settest them in slippery places: Thou castest them down to destruction. 19 How are they become a desolation in a moment! They are utterly consumed with terrors ... 27 For, lo, they that are far from thee shall perish: Thou hast destroyed all them that play the harlot, [departing] from thee. 28 But it is good for me to draw near unto God: I have made the Lord Jehovah my refuge, That I may tell of all thy works. Then M. Y. got astounding verses about what would happen to the wicked who opposed our building of the spiritual temple. In this text, those who persecuted the Jews as a faction stopped them from building the temple of God (as is happening now) were made to help them or be destroyed as is happening. Ezr.6:10 that they may offer sacrifices of sweet savor unto the God of heaven [the sacrifice of the flesh or dark man burning up in the fiery trial], and pray for the life of the king, and of his sons. 11 Also I have made a decree, that whosoever shall alter this word, let a beam be pulled out from his house, and let him be lifted up and fastened thereon [in other words, let him be crucified]; and let his house be made a dunghill for this. Then M.Y. got a text that speaks of the backsliding people of God from the Spirit-filled and non-Spirit-filled groups that were taken captive out of their land by the Beast because of their spiritual idols and spiritual fornication: Jer.3:8 And I saw, when, for this very cause that backsliding Israel (non-Spirit filled) had committed adultery, I had put her away and given her a bill of divorcement, yet treacherous Judah (Spirit-filled who had the House of God in their midst.) her sister feared not; but she also went and played the harlot. 9 And it came to pass through the lightness of her whoredom, that the land was polluted, and she committed adultery with stones and with stocks. 10 And yet for all this her treacherous sister Judah hath not returned unto me with her whole heart, but feignedly, saith Jehovah. In the rest of the text, the overcomers who came out of bondage were brought to the Bride, Jerusalem. 14 Return, O backsliding children, saith Jehovah; for I am a husband unto you: and I will take you one of a city, and two of a family, and I will bring you to Zion: 15 and I will give you shepherds according to my heart, who shall feed you with knowledge and understanding ... 17 At that time they shall call Jerusalem the throne of Jehovah; and all the nations [gentiles] shall be gathered unto it, to the name of Jehovah, to Jerusalem: neither shall they walk any more after the stubbornness of their evil heart. Notice the overcomers shall escape and be given the LAND. 19 But I said, How I will put thee among the children, and give thee a pleasant land, a goodly heritage of the hosts of the nations! and I said, Ye shall call me My Father, and shall not turn away from following me. Notice, once again, that the wicked will not stay in the Land; the righteous who walk by faith will. S. Y. asked for one more verse and it was about the wicked breaking their arms, just like the dream. Psa.37:17 For the arms of the wicked shall be broken; But Jehovah upholdeth the righteous. The rest of the text fits, too. 18 Jehovah knoweth the days of the perfect; And their inheritance shall be for ever. 19 They shall not be put to shame in the time of evil; And in the days of famine they shall be satisfied. 20 But the wicked shall perish, And the enemies of Jehovah shall be as the fat of lambs: They shall consume; In smoke shall they consume away. A dear friend, Bolivar, asked God what would happen to the carnal Christians in the coming days and got: Isa.65:9 And I will bring forth a seed out of Jacob, and out of Judah an inheritor of my mountains; and my chosen shall inherit it, and my servants shall dwell there. 10 And Sharon shall be a fold of flocks, and the valley of Achor (troubling) a place for herds to lie down in, for my people that have sought me. 11 But ye that forsake Jehovah, that forget my holy mountain, that prepare a table for Fortune [to profit the flesh], and that fill up mingled wine unto Destiny; 12 I will destine you to the sword, and ye shall all bow down to the slaughter; because when I called, ye did not answer; when I spake, ye did not hear; but ye did that which was evil in mine eyes, and chose that wherein I delighted not. 13 Therefore thus saith the Lord Jehovah, Behold, my servants shall eat, but ye shall be hungry; behold, my servants shall drink, but ye shall be thirsty; behold, my servants shall rejoice, but ye shall be put to shame; 14 behold, my servants shall sing for joy of heart, but ye shall cry for sorrow of heart, and shall wail for vexation of spirit. Psa.125:3 For the sceptre of wickedness shall not rest upon the lot of the righteous; That the righteous put not forth their hands unto iniquity. 4 Do good, O Jehovah, unto those that are good, And to them that are upright in their hearts. 5 But as for such as turn aside unto their crooked ways, Jehovah will lead them forth with the workers of iniquity. Peace be upon Israel. Zep.3:11 In that day shalt thou not be put to shame for all thy doings, wherein thou hast transgressed against me; for then I will take away out of the midst of thee thy proudly exulting ones, and thou shalt no more be haughty in my holy mountain. 12 But I will leave in the midst of thee an afflicted and poor people, and they shall take refuge in the name of Jehovah. 13 The remnant of Israel shall not do iniquity, nor speak lies; neither shall a deceitful tongue be found in their mouth; for they shall feed and lie down, and none shall make them afraid. Amo.9:10 All the sinners of my people shall die by the sword, who say, The evil shall not overtake nor meet us. 11 In that day will I raise up the tabernacle of David that is fallen, and close up the breaches thereof; and I will raise up its ruins, and I will build it as in the days of old; 12 that they may possess the remnant of Edom [the Davids will conquer those who sold their birthright to be sons of Abraham], and all the nations that are called by my name, saith Jehovah that doeth this.

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12/24/25 - "Blown Away by God's Love " - The Arrival | Christmas at Gilead 2025

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Play Episode Listen Later Dec 24, 2025 46:37

Message Notes for Today's Sermon. Click Here - https://gileadchurch.churchcenter.com/episodes/578459/notes Outline for Today's Sermon. Click Here - https://www.gileadchurch.com/wp-content/uploads/12-24-25.pdf Digital Connection Card Click Here to fill one out - https://gileadchurch.churchcenter.com/people/forms/202250 Having Trouble with the Live Stream? Click Here to watch on our website - https://www.gileadchurch.com/ Looking to Give Online? Click Here - https://www.gileadchurch.com/giving/ Did you make a decision today and want to take your Next Step? Click Here - https://www.gileadchurch.com/next-steps/ To Listen to Our Podcasts: Apple: https://podcasts.apple.com/us/podcast/gilead-church-podcast/id1729234971 Spotify: https://open.spotify.com/show/0sOidhOjzZepJFlQp2ZJWZ?si=9550f665a7fa4612 For More From Gilead Church: http://www.gileadchurch.com/ https://www.facebook.com/gileadchurch1/ https://www.instagram.com/gilead_church/

Maria Nisii "La casa dell'invisibile"

il posto delle parole

Play Episode Listen Later Dec 22, 2025 33:28

Maria Nisii"La casa dell'invisibile"Marilynne Robinson e la teologia del quotidianoEditrice Querinianawww.queriniana.itPrefazione di Gian Luca CarregaUna panoramica vasta e completa, che fa assaporare best-seller come GileadL'unico saggio italiano sulla dimensione teologica nelle opere di Marilynne Robinson, versante a volte trascurato ma di cruciale importanzaCon la sua scrittura accurata, Marilynne Robinson ha trasformato la letteratura in uno spazio sacro, dove la parola diventa casa dell'Invisibile e la narrazione strumento di grazia. In questo saggio Maria Nisii svela come l'autrice di Gilead, seguita e amata da moltissimi lettori anche in Italia, abbia ridisegnato i confini fra teologia e narrazione facendo della scrittura un atto liturgico. Attraverso un'analisi critica rigorosa e appassionata, che spazia in maniera completa dai romanzi ai saggi, emergono le radici calviniste di una visione artistica unica, capace di tradurre il mistero divino in personaggi affascinanti e in storie di ordinaria redenzione. Il lettore intraprenderà un viaggio nella poetica robinsoniana, dove ogni gesto – per quanto apparentemente banale, come un bagno in un fiume, una lettera paterna, un silenzio – riscatta il senso del vivere e rivela l'Eterno nel frammento. Queste pagine sono una bussola letteraria e teologica, utile tanto a lettori curiosi quanto a studiosi appassionati. Un'indagine originale e necessaria che li accompagna a scoprire, tra le pieghe del racconto, una delle voci più profonde del nostro tempo, che fa suo il sovvertimento evangelico dell'ordine costituito e trasforma il dubbio in bellezza e la solitudine in comunione.Maria Nisii, studiosa di americanistica e docente all'Istituto superiore di scienze religiose di Torino, da tempo si occupa dei rapporti tra letteratura e teologia; in quest'ambito svolge attività di divulgazione su riviste teologiche e in convegni nazionali e internazionali, nei podcast realizzati per l'ufficio di pastorale della cultura della sua diocesi, nella rubrica di poesia che cura per il periodico digitale Il foglio di Torino. Ha al suo attivo, fra l'altro, un saggio sulle riscritture bibliche: L'apocrifo necessario (Effatà, 2022).Marilynne Robinson, autrice di cinque romanzi e numerose raccolte di saggi, è fra le maggiori scrittrici americane viventi, e nel 2012 è stata insignita della National Humanities Medal. Il suo primo romanzo, Le cure domestiche (Einaudi 2016 e 2018), ha vinto nel 1982 il PEN/Hemingway Award per la miglior opera prima ed è stato inserito dal Guardian Unlimited fra i cento migliori romanzi di tutti i tempi. Con il successivo romanzo Gilead (Einaudi 2008 e 2017) ha vinto il National Book Critics Circle Award e il Pulitzer Prize. Casa (Eianudi 2011 e 2017) è stato finalista per il National Book Award e vincitore dell'Orange Prize e Lila (Einaudi 2015 e 2017) è risultato finalista per il National Book Award e vincitore del National Book Critics Circle Award. Einaudi ha pubblicato anche Jack (2021).Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/il-posto-delle-parole--1487855/support.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/

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12/21/25 - "Joy is Closer Than You Think" - The Arrival | Christmas at Gilead 2025

christmas spotify sermon livestream arrival next step outline gilead closer than you think give online

Play Episode Listen Later Dec 21, 2025 45:11

Message Notes for Today's Sermon. Click Here - https://gileadchurch.churchcenter.com/episodes/577311/notes Outline for Today's Sermon. Click Here - https://www.gileadchurch.com/wp-content/uploads/12-21-25.pdf Digital Connection Card Click Here to fill one out - https://gileadchurch.churchcenter.com/people/forms/202250 Having Trouble with the Live Stream? Click Here to watch on our website - https://www.gileadchurch.com/ Looking to Give Online? Click Here - https://www.gileadchurch.com/giving/ Weekly Announcements - https://www.gileadchurch.com/wp-content/uploads/WeeklyAnnouncements12-21-25.png Did you make a decision today and want to take your Next Step? Click Here - https://www.gileadchurch.com/next-steps/ To Listen to Our Podcasts: Apple: https://podcasts.apple.com/us/podcast/gilead-church-podcast/id1729234971 Spotify: https://open.spotify.com/show/0sOidhOjzZepJFlQp2ZJWZ?si=9550f665a7fa4612 For More From Gilead Church: http://www.gileadchurch.com/ https://www.facebook.com/gileadchurch1/ https://www.instagram.com/gilead_church/

218 - ICH Q13: Continuous Manufacturing EXPLAINED (Batch vs. Continuous)

Combinate Podcast - Med Device and Pharma

Play Episode Listen Later Dec 17, 2025 9:10

In this short episode of Let's Combinate: Drugs + Devices, Subhi Saadeh breaks down ICH Q13 and what “continuous manufacturing” actually means. He compares batch vs. continuous, explains how a batch still exists in continuous manufacturing, and covers the essentials quality teams care about: RTD/traceability, control strategy, and disturbances/diversion plus a quick high-level note on validation, release, and lifecycle.Timestamps00:00 Intro01:00 Batch vs. continuous (and batch definition)03:00 Modes of continuous manufacturing (ICH Q13 examples)04:30 RTD & traceability06:00 Control strategy07:30 Disturbances & diversion09:00 Validation / release / lifecycle (high level)10:00 Wrap-upSubhi Saadeh is the Founder and Principal of Let's Combinate BioWorks and host of the Let's Combinate: Drugs + Devices podcast/Youtube Channel. With experience across Quality, Manufacturing Commercialization, Sustaining and R&D, Subhi has helped industrialize and launch drug delivery systems for biologics, vaccines, and generics at leading organizations such as Pfizer, Gilead, and Baxter. Subhi focuses on bridging the disconnect between drug and device development and specializes in harmonizing internal systems, aligning internal and external partners, and helping combination product teams move from siloed execution to scalable, compliant, and patient-ready solutions. He currently chairs the Rx-360 Combination Product Working Group and was the International WG Chair at the Combination Product Coalition. He has contributed to global harmonization efforts through BIO, ASTM, and AAMI. He is a certified ISO13485 Lead Auditor, CQA and CQE.For questions, inquiries, or suggestions, please reach out at letscombinate.com or on the show's LinkedIn Page.

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Lilly's Triple Triumph, Prasad's COVID Error, J&J's Surprise Voucher, M&A Targets

BioSpace

Play Episode Listen Later Dec 17, 2025 20:04

Eli Lilly is wrapping up 2025 with record-breaking weight loss in a late-stage trial for its triple hormone receptor agonist retatrutide. Results from the Phase III TRIUMPH-4 trial exceeded analyst expectations, leading BMO Capital markets to cleverly dub it “a true TRIUMPH.” Also in the weight loss arena, Zealand Pharma inked a deal with China's OTR Therapeutics worth up to $2.5 billion to collaborate on next-gen drugs for obesity and other metabolic diseases, and Rhythm Pharmaceuticals awaits a Dec. 20 FDA verdict for Imcivree in hypothalamic obesity. Turning to the FDA, reports broke late last week that the agency was considering slapping a black box label—its strictest warning—on COVID-19 vaccines. Commissioner Marty Makary denied those reports on Monday, stating on Bloomberg TV that the FDA has “no plans” to make such a move. This follows an internal memo from Vinay Prasad leaked over Thanksgiving in which the CBER director claimed that “at least” 10 children have died “because of” COVID-19 vaccines. An internal safety review published last week refuted this conclusion, instead concluding that between zero and seven deaths could be linked to the shots. Pfizer CEO Albert Bourla, for one, is tired of the recent rhetoric from HHS on vaccines and hopes they are “an anomaly” that will be corrected soon. With strong words about the administration's sentiment on vaccines, Bourla prominsed Pfizer's continued investment in vaccines despite declining revenue. Pfizer this week lowered its 2026 guidance to $62.5 billion in revenue, missing analyst consensus. The FDA has also granted several approvals in the past week, to Amgen, Milestone Pharmaceuticals and AstraZeneca and Daiichi Sankyo. USAntibiotics also snagged a greenlight, for Augmentin XR, the first approval to be given under the agency's new Commissioner's National Priority Voucher (CNPV) program. Also this week, Johnson & Johnson scored a CNPV ticket—without even having to apply—for its investigational combo of Tecvayli plus Darzalex for relapsed or refractory multiple myeloma after the FDA was impressed by Phase III data. In ClinicaSpace this week, we highlighted 5 of 2025's Defining Clinical Wins and The 5 Most Painful Clinical Trial Failures of 2025. This past week provided a few more on each front. In the winner's circle, Immunome's desmoid tumor drug and and Kyverna's CAR T for stiff person syndrome both aced pivotal trials, while Sanofi's MS drug tolebrutinib and Gilead and Arcus' TIGIT therapy domvanalimab each failed Phase III tests. And in BioPharm Executive, we highlight 6 Biotechs That Could Be Big Pharma's Next M&A Target, and more M&A predictions for 2026.

240: KWP Bookclub Review of Gilead.

King's Way Podcast

Play Episode Listen Later Dec 16, 2025 38:50

"Sometimes I have loved the peacefulness of an ordinary Sunday. It is like standing in a newly planted garden after a warm rain. You can feel the silent and invisible life."Welcome to our final episode of the King's Way Podcast Book Club for 2025! If you haven't already read the book we're reviewing, don't worry–this could be the talk you need to get you interested in reading it. And if you have read it, welcome to the club!In this episode, Trevor and Ryan talk about a surprisingly beautiful, restful book: Gilead, by Marilynne Robinson. Treading the path between historical fictional narrative and pastoral theology, the author follows the letters of a fictional aging pastor in Gilead, Iowa as he prepares for his inevitable death from his old, failing body, written to his very young son in hopes that his son will get to know who his father was when he gets old enough to appreciate it. If you find narratives easier to digest than monologues or diatribes, this may be the perfect faith book for you!As always, you can join the conversation by letting us know what you thought of the book or our conversation!

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461. ROAD TO GILEAD: Homophobia and How to Fight It with Jessica Fosekew and Russell T Davies

Play Episode Listen Later Dec 15, 2025 97:55

The Guilty Feminist 461. Homophobia and How to Fight It Presented by Deborah Frances-White and Jessica Fostkew with special guest Russell T Davies Recorded 6 December 2025 at Soho Theatre. Released 15 December. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Jessica Fostekew https://www.instagram.com/jessicafostekew More about Russell T Davies https://www.instagram.com/russelltdavies63 https://www.bbc.co.uk/programmes/m002dr53 For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Open Space Event, 17 January. https://www.eventbrite.co.uk/e/road-to-gilead-open-space-event-tickets-1976897741361 Museum of Comedy, 13 February, 20 February, 5 March. https://www.museumofcomedy.com/the-guilty-feminist Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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12/14/25 - "Peace for the Anxious Mind" - The Arrival | Christmas at Gilead 2025

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Play Episode Listen Later Dec 14, 2025 43:31

Message Notes for Today's Sermon. Click Here - https://gileadchurch.churchcenter.com/episodes/573845/notes Outline for Today's Sermon. Click Here - https://www.gileadchurch.com/wp-content/uploads/12-14-25.pdf Digital Connection Card Click Here to fill one out - https://gileadchurch.churchcenter.com/people/forms/202250 Having Trouble with the Live Stream? Click Here to watch on our website - https://www.gileadchurch.com/ Looking to Give Online? Click Here - https://www.gileadchurch.com/giving/ Did you make a decision today and want to take your Next Step? Click Here - https://www.gileadchurch.com/next-steps/ To Listen to Our Podcasts: Apple: https://podcasts.apple.com/us/podcast/gilead-church-podcast/id1729234971 Spotify: https://open.spotify.com/show/0sOidhOjzZepJFlQp2ZJWZ?si=9550f665a7fa4612 For More From Gilead Church: http://www.gileadchurch.com/ https://www.facebook.com/gileadchurch1/ https://www.instagram.com/gilead_church/

Episode 393: Antibody–Drug Conjugates in Metastatic Breast Cancer

The Oncology Nursing Podcast

Play Episode Listen Later Dec 12, 2025 20:42

"I'll go back to the backpack analogy. When your kids come home with a backpack, all of a sudden their homework is not on the desk where it's supposed to be. It's in the kitchen; it kind of spreads all over the place, but it's still in the house. When we give antibody–drug conjugates (ADCs), the chemotherapy does go in, but then it can kind of permeate out of the cell membrane and something right next to it—another cancer cell that might not look exactly like the cancer cell that the chemotherapy was delivered into—is affected and the chemotherapy goes over to that cancer cell and kills it," ONS member Marisha Pasteris, OCN®, office practice nurse in the breast medicine service at Memorial Sloan Kettering Cancer Center in New York, NY, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about ADCs in metastatic breast cancer. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 This podcast is sponsored by Gilead and is not eligible for NCPD contact hours. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Episode Notes This episode is not eligible for NCPD. ONS Podcast™ episodes: Episode 391: Pharmacology 101: Antibody–Drug Conjugates Episode 378: Considerations for Adolescent and Young Adult Patients With Metastatic Breast Cancer Episode 368: Best Practices for Challenging Patient Conversations in Metastatic Breast Cancer Episode 350: Breast Cancer Treatment Considerations for Nurses Episode 303: Cancer Symptom Management Basics: Ocular Toxicities ONS Voice articles: An Oncology Nurse's Guide to Cancer-Related Ocular Toxicities Black Patients With Metastatic Breast Cancer Are Less Informed About Their Clinical Trial Options Communication Case Study: Talking to Patients About Progressive Metastatic Breast Cancer What Is HER2-Low Breast Cancer? ONS Voice drug reference sheets: Belantamab mafodotin-blmf Datopotamab deruxtecan-dlnk Enfortumab vedotin-ejfv Fam-trastuzumab deruxtecan-nxki ONS books: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) Guide to Breast Care for Oncology Nurses Guide to Cancer Immunotherapy (second edition) ONS courses: ONS Fundamentals of Chemotherapy and Immunotherapy Administration™ ONS/ONCC® Chemotherapy Immunotherapy Certificate™ Clinical Journal of Oncology Nursing article: Antibody–Drug Conjugates and Ocular Toxicity: Nursing, Patient, and Organizational Implications for Care The Association Between Hormone Receptor Status and End-of-Life Care Among Patients With Metastatic Breast Cancer Oncology Nursing Forum article: Impact of Race and Area Deprivation on Triple-Negative Metastatic Breast Cancer Outcomes ONS huddle cards: Altered Body Image Huddle Card Chemotherapy Huddle Card Targeted Therapy Huddle Card Foundations of Antibody–Drug Conjugate Use in Metastatic Breast Cancer: A Case Study ONS Biomarker Database (refine by breast cancer) ONS Breast Cancer Learning Library American Society of Clinical Oncology (ASCO) homepage Drugs@FDA package inserts National Comprehensive Cancer Network homepage Susan G. Komen metastatic breast cancer page To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "What an ADC is doing is taking the antibody and linking it to a cytotoxic chemotherapy with the idea of delivering it directly into the cell. How I explain this to new nurses or patients is a backpack analogy. If we think of it as a HER2 molecule wearing a chemo backpack, it's going to find the HER2 receptor attached to it and then drop the chemotherapy into the cell via the backpack. Similar to how we come home from work, we open the key to our door, we're carrying all of our items, and then we drop our own personal items in our house." TS 2:30 "The reason that so many patients with metastatic breast cancer are able to receive ADC therapy is because they are targeting two very common antibodies that we see in breast cancer. One is HER2 and the other is trophoblast cell surface antigen 2 (TROP2). These are seen across the board. We see these on triple-negative breast cancers, hormone receptor–positive cancers, and HER2-positive breast cancers. And now we have a new way to talk about HER2, which is a HER2-low. ... Recently, we have found that patients who express low levels of HER2 are able to receive ADC therapy, specifically fam-trastuzumab deruxtecan." TS 4:21 "Another [ADC] that has just been approved is datopotamab deruxtecan. This is another ADC that targets the TROP2 receptor on a cancer cell. This one carries a lot of side effects. I mentioned earlier that you need an ophthalmology clearance because there is a lot of ocular toxicity around this one. We see a lot of blepharitis, conjunctivitis, there can be blurred vision. Another thing we monitor on this one is mucositis. In the package insert, there's a recommendation for using ice chips while receiving the treatment. ... Then in the HER2-positive and HER2-low space is the big one, which is fam-trastuzumab deruxtecan. This was approved in 2019 for the HER2-positive patients, then more recently in the HER2-low [patients]. The big [side effect] with this one is interstitial lung disease." TS 10:11 "Interstitial lung disease is an inflammation or a little bit of fibrosis within the lung that causes an impaired exchange between the oxygen and carbon dioxide. This was seen in the clinical trials, specifically around fam-trastuzumab deruxtecan. During the trials, they had a very small percentage, I think it was 1%, that died due to interstitial lung disease. So, this is a very important side effect for us as nurses to be aware of. It typically presents in patients like a dyspnea. A lot of times, it's like, 'Well, I used to be able to walk my kid to the bus stop, but now when I walk there, I feel really short of breath.' Or 'I've had this dry cough for the past couple weeks and I've tried medications, but haven't had that relieved.' So, we really need to be aware of that because early intervention in interstitial lung disease is key." TS 12:57 "ADCs are toxic drugs. They have the benefit of being targeted, but we know that they carry a lot of side effects. ... Their specificity makes them so wonderful and we've seen amazing responses to these drugs. But also, we want patients to be safe. We want to give these drugs safely. So, we have to assess our patients and make sure that this is an appropriate patient to give this therapy to. I think that's an open conversation that clinicians need to have with patients regarding these drugs." TS 18:08

LIVE DISCUSSION: Job 7:3-9 - An Appealing Death - Part 3 of 4

The Bible Provocateur

Play Episode Listen Later Dec 11, 2025 32:40 Transcription Available

Send us a textWhat if the story of Job is not a moral about grit but a roadmap for grace? We dive into Job's raw language—worms, cracked skin, and the weaver's shuttle—to uncover a richer truth about sanctification: God starts the relationship and God keeps it, even when life feels like living decomposition. Along the way, we challenge a common myth that faithfulness means sinless perfection. Faithfulness, we argue, looks like confession, repentance, and getting up under mercy.We also tackle a hot-button claim: salvation has never changed. From Abraham to Job to Paul to us, the ground is the same—saved by grace through faith in Christ alone. Galatians becomes our guide against add-ons, whether ancient circumcision or modern checklists. We examine how ritual, culture, and pressure try to smuggle requirements into the gospel, and we walk through why those attempts collapse under Scripture's weight. The contrast is freeing: ordinances are gifts, not gates; Jesus is the gate.When we reach Job 7, the imagery opens a deeper layer. Job's body paints a spiritual mirror of human depravity without the Lord, and into that ache we name Christ as the balm of Gilead—the healer who treats not just wounds but the rot beneath them. We reckon with the speed of life and the silence that can follow prayer, then explore what it means to suffer well: to tell the truth about pain, to appeal to God's compassion, and to trust that the One who began a good work will carry it to completion.If you're wrestling with shame, struggling with add-on religion, or wondering how to find purpose when days blur, this conversation meets you where you are. Listen, share with a friend who needs courage, and if it helped you see Job—or Jesus—more clearly, subscribe and leave a review so others can find it too.Support the showBE PROVOKED AND BE PERSUADED!

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5 Fixable Problems Holding Back Drug–Device Programs

Combinate Podcast - Med Device and Pharma

Play Episode Listen Later Dec 10, 2025 17:30

In this episode of Let's Combinate: Drugs + Devices, host Subhi Saadeh addresses five significant quality issues in the combination product space. This episode provides practical insights and strategies for overcoming these common hurdles to enhance quality and efficiency in developing combination products.00:00 Introduction and Host Background00:43 Overview of Development Processes01:51 Issue 1: Documentation Approach in Design Transfer04:45 Issue 2: Early Input from Manufacturing and Assembly SMEs07:26 Issue 3: Control Strategies and Sampling Plans10:23 Issue 4: Method Transfer and Control Planning12:02 Issue 5: Qualification of Supplied Components14:47 Issue 6: Monitoring Expectations in Combination Products16:55 Conclusion and SummarySubhi Saadeh is the Founder and Principal of Let's Combinate BioWorks and host of the Let's Combinate: Drugs + Devices podcast/Youtube Channel. With experience across Quality, Manufacturing Commercialization, Sustaining and R&D, Subhi has helped industrialize and launch drug delivery systems for biologics, vaccines, and generics at leading organizations such as Pfizer, Gilead, and Baxter. Subhi focuses on bridging the disconnect between drug and device development and specializes in harmonizing internal systems, aligning internal and external partners, and helping combination product teams move from siloed execution to scalable, compliant, and patient-ready solutions. He currently chairs the Rx-360 Combination Product Working Group and was the International WG Chair at the Combination Product Coalition. He has contributed to global harmonization efforts through BIO, ASTM, and AAMI. He is a certified ISO13485 Lead Auditor, CQA and CQE.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

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460. ROAD TO GILEAD: Making Our Voices Heard with Jessica Fosekew, Baroness Barker and Monica Ferro

Play Episode Listen Later Dec 8, 2025 97:06

The Guilty Feminist 460. Making Our Voices Heard Presented by Deborah Frances-White and Jessica Fostkew with special guests Baroness Barker and Monica Ferro Recorded 16 November 2025 at The Museum of Comedy. Released 8 December. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have Amnesty International is the world's largest grassroots human rights organisation, working tirelessly to expose human rights abuses, hold power to account, and campaign for a fairer, safer world. We stand stronger together. Join the Amnesty International community and support their work exposing truth, debunking narratives, confronting perpetrators, defending truth-tellers and equipping communities with evidence to demand change: https://donate.giveasyoulive.com/campaign/amnesty-guilty-feminist-november-2025 More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Jessica Fostekew https://www.instagram.com/jessicafostekew More about Baroness Liz Barker https://members.parliament.uk/member/2501/contact https://www.instagram.com/p/DGQqvX3i7ZE More about Monica Ferro https://www.instagram.com/monicaferrounfpa To fight for change, we need you. Donate today and power us into 2026. https://ayzqzzms.donorsupport.co/page/buildhope For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Museum of Comedy: Friday 13 Feb, Friday 20 Feb, Thursday 5 March. Tickets on sale soon. Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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12/7/25 - "Hope When It Feels Hopeless" - The Arrival | Christmas at Gilead 2025

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Play Episode Listen Later Dec 7, 2025 44:25

Message Notes for Today's Sermon. Click Here - https://gileadchurch.churchcenter.com/episodes/571155/notes Outline for Today's Sermon. Click Here - https://www.gileadchurch.com/wp-content/uploads/12-7-25.pdf Digital Connection Card Click Here to fill one out - https://gileadchurch.churchcenter.com/people/forms/202250 Having Trouble with the Live Stream? Click Here to watch on our website - https://www.gileadchurch.com/ Looking to Give Online? Click Here - https://www.gileadchurch.com/giving/ Did you make a decision today and want to take your Next Step? Click Here - https://www.gileadchurch.com/next-steps/ To Listen to Our Podcasts: Apple: https://podcasts.apple.com/us/podcast/gilead-church-podcast/id1729234971 Spotify: https://open.spotify.com/show/0sOidhOjzZepJFlQp2ZJWZ?si=9550f665a7fa4612 For More From Gilead Church: http://www.gileadchurch.com/ https://www.facebook.com/gileadchurch1/ https://www.instagram.com/gilead_church/

Season 3 - Ep.28: DAPT: how short is too short? - Obesity and atrial fibrillation

Play Episode Listen Later Dec 4, 2025 25:51

This episode covers: Cardiology This Week: A concise summary of recent studies DAPT: how short is too short Obesity and atrial fibrillation Milestones: COURAGE Host: Emer Joyce Guests: Carlos Aguiar, Steffen Massberg, Prash Sanders Want to watch that episode? Go to: https://esc365.escardio.org/event/2178 Want to watch that extended interview on dual antiplatelet therapy (DAPT) and shortening its optimal duration, go to: https://esc365.escardio.org/event/2178?resource=interview Disclaimer ESC TV Today is supported by Bristol Myers Squibb and Novartis through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Emer Joyce, Nicolle Kraenkel and Steffen Massberg have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Prashanthan Sanders has declared to have potential conflicts of interest to report: advisory board representative University of Adelaide, Medtronic, Boston Scientific, CathRx, Abbott and Pacemate as well as research grants for University of Adelaide: Medtronic, Abbott, Boston Scientific, Becton Dickson. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

459. THE ROAD TO GILEAD: Christian Nationalism with Felicity Ward, Minnie Rahman and Lucy Winkett

WELS Through my Bible in Three Years

Play Episode Listen Later Dec 1, 2025 96:51

The Guilty Feminist 459. Christian Nationalism Presented by Deborah Frances-White and Felicity Ward with special guests Minnie Rahman and Lucy Winkett Recorded 10 November 2025 at The Pleasance London. Released 1 December. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have Amnesty International is the world's largest grassroots human rights organisation, working tirelessly to expose human rights abuses, hold power to account, and campaign for a fairer, safer world. We stand stronger together. Join the Amnesty International community and support their work exposing truth, debunking narratives, confronting perpetrators, defending truth-tellers and equipping communities with evidence to demand change: https://donate.giveasyoulive.com/campaign/amnesty-guilty-feminist-november-2025 More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Felicity Ward https://www.instagram.com/felicityward https://www.felicityward.com More about Lucy Winkett https://www.sjp.org.uk/whos-who/lucy-winkett More about Minnie Rahman https://bsky.app/profile/minnierahman.bsky.social To fight for change, we need you. Donate today and power us into 2026. https://ayzqzzms.donorsupport.co/page/buildhope For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Russell T Davies at Soho Theatre https://sohotheatre.com/events/the-guilty-feminist-9/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Through My Bible Yr 02 – November 26

Play Episode Listen Later Nov 26, 2025 4:09

#top .av-special-heading.av-gs9o3p-10fce76745a76900b9e52f5079e04520{ padding-bottom:10px; } body .av-special-heading.av-gs9o3p-10fce76745a76900b9e52f5079e04520 .av-special-heading-tag .heading-char{ font-size:25px; } .av-special-heading.av-gs9o3p-10fce76745a76900b9e52f5079e04520 .av-subheading{ font-size:15px; } Through My Bible Yr 02 – November 26Song of Songs 6:4 – 8:4 LISTEN HERE Through My Bible – November 26 Song of Songs 6:4 – 8:4 (EHV) https://wels2.blob.core.windows.net/tmb-ehv/02-1126db.mp3 See series: Through My Bible Song of Songs 6 You Are Beautiful The Man 4 You are as beautiful, my darling, as Tirzah, [1] lovely as Jerusalem, majestic as troops with banners. 5 Turn your eyes away from me, because they arouse me. Your hair is like a flock of goats flowing down from Gilead. 6 Your teeth are like a flock of ewes coming up from the washing. Each has its twin. Not one of them is alone. 7 Your cheeks behind your veil are like the halves of a pomegranate. 8 There may be sixty queens, and eighty concubines, and virgins beyond number, 9 but my dove, my perfect one, is one of a kind. She is the only daughter of her mother, pure to the one who bore her. The girls saw her and called her blessed. The queens and concubines also praised her. The Friends 10 Who is this woman that appears like the dawn, beautiful as the moon, clear as the sun, majestic as the stars in procession? A Puzzling Interlude The Woman or The Man [2] 11 I went down to the grove of nut trees, to look at the new growth in the valley, to see whether the vines had budded, whether the pomegranates had blossomed. 12 Before I realized it, my desire set me among the chariots of my willing people. [3] Beautiful From Bottom to Top The Friends 13 Turn back, turn back, O Shulammite. Turn back, turn back, so that we may look at you! [4] The Woman [5] Song of Songs 7 1 Why would you look at the Shulammite. as at the dance of Mahanaim? [6] The Friends or The Man 2 How beautiful are your feet in sandals, O prince's daughter! Your hips are curved like a necklace, the work of the hands of a craftsman. 3 Your navel is a round mixing bowl. It never lacks blended wine. Your belly is a mound of wheat, encircled by lilies. 4 Your two breasts are like two fawns, twins of a gazelle. 5 Your neck is like an ivory tower. Your eyes are the pools in Heshbon, by the gate of Bat Rabbim. [7] Your nose is like the tower of Lebanon, overlooking Damascus. 6 Your head rises above you like Mount Carmel. The flowing hair of your head is like purple. The king is captivated by its curls. The Man 7 How beautiful you are and how pleasing, O loved one, daughter of delights! [8] 8 Your height is like that of the date palm, and your breasts like clusters of fruit. 9 I said, “I will climb the date palm. I will take hold of its bunches of fruit.” May your breasts be like the clusters of the vine, the fragrance of your breath like apples, 10a and your mouth like the best wine— The Woman 10b —flowing to my lover, gliding smoothly over lips and teeth. [9] 11 I belong to my lover, and his desire is for me. 12 Come, my lover, let us go to the fields. Let us spend the night in the villages. 13 Let us go early to the vineyards. We will see if the vines have budded, if their blossoms have opened, if the pomegranates are in bloom. There I will give my love to you. The mandrakes send out their fragrance. At our door is every delicacy, new as well as old, that I have stored up for you, my lover. He Embraces Me The Woman Song of Songs 8 1 I wish that you were like a brother to me, who was nursed at my mother's breasts. Then if I would meet you in public, I could kiss you, and no one would despise me. 2 I would lead you. I would bring you to my mother's house where she used to teach me. I would give you spiced wine to drink, the juice of my pomegranates. 3 His left arm is under my head, and his right arm embraces me. 4 Daughters of Jerusalem, you must swear that you will not arouse or awaken love until it so desires. Footnotes Song of Songs 6:4 Tirzah is a city in Israel. Its name means delightful. Song of Songs 6:11 The identity of the speaker of these verses is uncertain. Song of Songs 6:12 This is a difficult verse of uncertain meaning. Song of Songs 6:13 English verse 6:13 is 7:1 in Hebrew. In the rest of chapter 7, the English verse numbers are one lower than the Hebrew verse numbers. Song of Songs 7:1 The identity of the speaker of this verse is uncertain. Song of Songs 7:1 Mahanaim is the name of a city. It means two camps. Here the term may refer to two lines of dancers. Song of Songs 7:5 Bat Rabbim means Daughter of Nobles. Song of Songs 7:7 The translation follows a textual variant supported by the ancient versions. The Hebrew text reads O love, with delights. Song of Songs 7:10 The reading lips and teeth is well attested by the ancient versions. The Hebrew reads lips of sleepers. #top .hr.hr-invisible.av-aocsdx-89cb4ca21532423cf697fc393b6fcee0{ height:10px; } The Holy Bible, Evangelical Heritage Version®, EHV®, © 2019 Wartburg Project, Inc. All rights reserved. #top .hr.hr-invisible.av-4vzadh-3f04b370105df1fd314a2a9d83e55b26{ height:50px; } Share this entryShare on FacebookShare on LinkedInShare by MailLink to FlickrLink to InstagramLink to Vimeo

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Season 3 - Ep.27: 'ChatGPT, MD?': large language models at the bedside - Management decisions in myocarditis

Play Episode Listen Later Nov 20, 2025 23:24

This episode covers: Cardiology This Week: A concise summary of recent studies 'ChatGPT, MD?' - Large Language Models at the Bedside Management decisions in myocarditis Statistics Made Easy: Mendelian randomisation Host: Emer Joyce Guests: Carlos Aguiar, Folkert Asselbergs, Massimo Imazio Want to watch that episode? Go to: https://esc365.escardio.org/event/2179 Want to watch that extended interview on 'ChatGPT, MD?': Large Language Models at the Bedside? Go to: https://esc365.escardio.org/event/2179?resource=interview Disclaimer: ESC TV Today is supported by Bristol Myers Squibb and Novartis through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Folkert Asselbergs, Yasmina Bououdina, Massimo Imazio, Emer Joyce, and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

Season 3 - Ep.27: Extended interview on 'ChatGPT, MD?': large language models at the bedside

Play Episode Listen Later Nov 20, 2025 10:00

Host: Emer Joyce Guest: Folkert Asselbergs Want to watch that episode? Go to: https://esc365.escardio.org/event/2179 Want to watch that extended interview on 'ChatGPT, MD?': Large Language Models at the Bedside? Go to: https://esc365.escardio.org/event/2179?resource=interview Disclaimer: ESC TV Today is supported by Bristol Myers Squibb and Novartis through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Folkert Asselbergs, Yasmina Bououdina, Emer Joyce, and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. E mma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson. Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

457. ROAD TO GILEAD: The Fight Back for Gender Justice with Alison Spittle and Chiara Capraro

Play Episode Listen Later Nov 17, 2025 85:10

The Guilty Feminist 457. The Fight Back for Gender Justice Presented by Deborah Frances-White and Alison Spittle with special guest Chiara Capraro Recorded 4 November 2025 at The Pleasance London. Released 17 November. The Guilty Feminist theme composed by Mark Hodge. Get Deborah's new book with 30% off using the code SIXCONVERSATIONSPOD https://store.virago.co.uk/products/six-conversations-were-scared-to-have Amnesty International is the world's largest grassroots human rights organisation, working tirelessly to expose human rights abuses, hold power to account, and campaign for a fairer, safer world. We stand stronger together. Join the Amnesty International community and support their work exposing truth, debunking narratives, confronting perpetrators, defending truth-tellers and equipping communities with evidence to demand change: https://donate.giveasyoulive.com/campaign/amnesty-guilty-feminist-november-2025 More about Deborah Frances-White https://deborahfrances-white.com https://www.instagram.com/dfdubz https://www.virago.co.uk/titles/deborah-frances-white/six-conversations-were-scared-to-have/9780349015811 https://www.virago.co.uk/titles/deborah-frances-white/the-guilty-feminist/9780349010120 More about Jessica Fostekew https://www.instagram.com/jessicafostekew More about Chiara Capraro https://www.amnesty.org.uk/amnesty-uk-spokespeople https://www.linkedin.com/in/chiaracapraro For more information about this and other episodes… visit https://www.guiltyfeminist.com tweet us https://www.twitter.com/guiltfempod like our Facebook page https://www.facebook.com/guiltyfeminist check out our Instagram https://www.instagram.com/theguiltyfeminist or join our mailing list http://www.eepurl.com/bRfSPT More Big Speeches workshops now available https://guiltyfeminist.com/big-speeches/ Come to a live show Bill Murray, 23 November https://link.dice.fm/F147b081b51d Russell T Davies at Soho Theatre https://sohotheatre.com/events/the-guilty-feminist-9/ Thank you to our amazing Patreon supporters. To support the podcast yourself, go to https://www.patreon.com/guiltyfeminist You can also get an ad-free version of the podcast via Apple Podcasts. The Guilty Feminist is part of The AudioPlus Network. If you'd like to work with us, please get in touch at hello@weareaudioplus.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

released bill murray fight back amnesty international chiara gilead soho theatre gender justice guilty feminist deborah frances white alison spittle jessica fostekew mark hodge

Tecnológicas en Retroceso, Ley GAIN AI y Ofertas por Warner Bros.

WALL STREET COLADA

Play Episode Listen Later Nov 14, 2025 2:28

What Will You Be Remembered For? | Judges 12:7

god wrapping up gilead handmaid's tale handmaids tale season

Play Episode Listen Later Nov 13, 2025 2:56

Welcome to The Daily, where we study the Bible verse by verse, chapter by chapter, every day. Today's shout-out goes to Nathan Cofsky from Falls Church, VA. Your commitment through Project23 helps deliver God's Word daily with clarity and conviction. This one's for you. Our text today is Judges 12:7. Jephthah judged Israel six years. Then Jephthah the Gileadite died and was buried in his city in Gilead. — Judges 12:7 Jephthah's rule lasted only six years. That's shorter than most judges in Israel's history. Though he delivered Israel from the Ammonites, his legacy was tarnished by internal conflict and a tragic vow that cost his daughter's life. His reign ended quickly, his story remembered with more grief than glory. The measure of a life isn't only in achievements, but in the wake we leave behind. Jephthah's victories were real, but his pride and rashness left wounds that outlived him. Too many chase success—winning battles, reaching goals, building careers. But legacy isn't only about the trophies we collect; it's also about the lives we impact. A short rule like Jephthah's reveals how quickly success can fade when it isn't paired with wisdom, humility, and faithfulness. What do you want people to remember about you? Will it be your titles, your victories, your wealth—or your faith, your humility, your love? The truth is, your true legacy isn't your success—it's your succession. What you hand off—faith to your children, character to your coworkers, hope to your community—outlasts every accomplishment. Don't spend your life building monuments to yourself. Spend it building people for the Lord. Success fades, but a godly legacy always multiplies. ASK THIS: What do I want to be remembered for most? Am I living more for personal success or lasting legacy? What am I handing off to those who come after me? DO THIS: Write down three words you want people to say about you when you're gone. Then ask: Does my life right now match those words? Start aligning today's actions with tomorrow's legacy. PRAY THIS: Father, teach me to live with legacy in mind. Guard me from chasing empty success, and help me hand off faith, character, and love that point others to You long after I'm gone. Amen. PLAY THIS: "Only Jesus."

god success lord israel bible va judges guard amen remembered gilead jephthah ammonites falls church gileadite

How Nimbus CEO Abbas Kazimi Builds Resilient Pipelines Through Culture, Rigor & Smart Bets

Biotech 2050 Podcast

Play Episode Listen Later Nov 13, 2025 42:37

Synopsis: Nimbus Therapeutics CEO Abbas Kazimi walks Alok Tayi through the company's evolving pipeline and playbook for choosing the right risks in a noisy biotech environment. From Werner helicase for MSI-high cancers to a highly selective SIK2 program and GLP-1–adjacent strategies focused on body composition, Abbas details how Nimbus balances rigor, speed, and capital efficiency. He shares candid lessons from pausing and later resurrecting AMPK beta in partnership with Eli Lilly, the decision to remain modality-agnostic but small-molecule-centric, and the importance of knowing when not to chase the latest fad. Throughout, Abbas returns to a consistent theme: success at Nimbus comes from disciplined target selection, deep collaboration, and a culture that empowers teams to make hard calls in service of patients rather than headlines. Biography: Abbas Kazimi is the Chief Executive Officer of Nimbus Therapeutics. Previously, he served as Chief Business Officer, leading the company's strategic and corporate development efforts while overseeing business operations. Since joining Nimbus in 2014, he has helped raise over $630 million in equity financing and led transactions totaling more than $8 billion. Notably, Mr. Kazimi spearheaded the $6 billion sale of Nimbus's TYK2 program to Takeda, the $1.2 billion sale of its NASH (ACC) program to Gilead, and multiple licensing deals exceeding $1.5 billion with partners such as Genentech, Celgene/Roche, and Eli Lilly. Under his leadership, Nimbus has advanced four programs into the clinic, returned over $4 billion to investors, and continues to expand its computational drug discovery and clinical development capabilities. In 2025, Mr. Kazimi joined the board of Unnatural Products (UNP), a biotech company pioneering orally delivered macrocyclic peptides to tackle previously undruggable targets. He also serves on the Editorial Advisory Board for In Vivo magazine, a leading publication offering strategic insights and analysis of the pharmaceutical, biotechnology, medtech, and consumer health industries. Along with his family, he established the Kazimi Family Endowment for Data Science in Oncology at MD Anderson Cancer Center. This endowment reflects their personal commitment to philanthropy and their vision for revolutionizing cancer treatment through data-driven innovation. At the core of Mr. Kazimi's leadership is a deep sense of purpose—one that seeks to change the trajectory of medical diagnoses where options are limited. The ability to give patients, prescribers, and families a new outlook on life is a powerful responsibility—and one he knows the biopharmaceutical sector has the ability to fulfill. Before Nimbus, he was at Extera Partners, LLC (formerly PureTech Development, LLC), where he provided strategic advisory, supported fundraising, and executed numerous business development transactions. Earlier in his career, he was with JSB-Partners, LP, a specialized investment banking and advisory firm serving biotech and pharmaceutical companies. Mr. Kazimi holds a B.A. from the University of Texas at Austin and an M.S. from Harvard University.

BONUS: Wrapping-up "The Handmaids Tale (Season 1)"

That Show F*cked Me Up!

Play Episode Listen Later Nov 13, 2025 50:41

Who knew that were religious groups out there who have similar beliefs to that of Gilead?! To that I ask, isn't God supposed to treat everyone with kindness, and offer a helping hand? Where did y'all read about treating women like sh!t, and only thinking they're worthy if they're able to bear children, and listen to their husbands? Gilead, Gloriavale- They both start with a G, and they both love to dress their women in long dresses and bonnets. Hope you enjoy this wrap-up episode! See you in a couple of weeks.

42,000 Lives Were Lost to Pride | Judges 12:5-6

Play Episode Listen Later Nov 12, 2025 3:39

Welcome to The Daily, where we study the Bible verse by verse, chapter by chapter, every day. Today's shout-out goes to William Childress from Clanton, AL. Your commitment through Project23 helps deliver God's Word daily with clarity and conviction. This one's for you. Our text today is Judges 12:5-6. And the Gileadites captured the fords of the Jordan against the Ephraimites. And when any of the fugitives of Ephraim said, "Let me go over," the men of Gilead said to him, "Are you an Ephraimite?" When he said, "No," they said to him, "Then say Shibboleth," and he said, "Sibboleth," for he could not pronounce it right. Then they seized him and slaughtered him at the fords of the Jordan. At that time 42,000 of the Ephraimites fell. — Judges 12:5-6 The pride-fueled conflict between Ephraim and Gilead spiraled into devastation. At the Jordan River crossings, men were identified by a single word—"Shibboleth." Ephraim's inability to pronounce it exposed them, and 42,000 were slaughtered. This wasn't just a loss of numbers; it was a loss of brothers. Israel's strength was drained not by foreign invaders, but by internal division. Pride always extracts a heavier toll than we imagine. Pride blinds us. It convinces us that winning the argument, defending our ego, or holding the grudge is worth it. But pride always takes more than it gives. For Ephraim, it cost 42,000 lives. For us, pride may not take thousands, but it can destroy marriages, split churches, fracture friendships, and poison families. The irony is, pride promises control but always delivers destruction. It tricks us into thinking we're winning when we're really losing. It makes us fight battles we never needed to fight and leaves scars we never needed to carry. Pride robs marriages of peace, friendships of trust, churches of unity, and leaders of influence. But humility does the opposite. It restores what pride destroys. It creates peace, strengthens relationships, and builds trust where pride would tear it down. Don't wait until pride costs you everything to discover it's not worth the price. Choose humility now—before pride takes what you can never get back. The cost of pride is devastation, but the opportunity of humility is life, peace, and blessing. ASK THIS: Where is pride quietly at work in my life right now? What relationships am I putting at risk because of stubborn ego? Do I really believe humility saves more than pride ever can? DO THIS: Today, choose one area where pride is whispering, "Defend yourself." Instead, practice humility. Admit the fault, forgive the offense, or let go of the need to win. PRAY THIS: Lord, protect me from the cost of pride. Give me humility to value unity over ego and peace over being right. Help me see that humility leads to life, but pride always ends in destruction. Amen. PLAY THIS: "Humble King."

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The Shibboleth Test: Pride That Divides | Judges 12:4-6

Play Episode Listen Later Nov 11, 2025 4:34

Welcome to The Daily, where we study the Bible verse by verse, chapter by chapter, every day. And since today is Veterans Day, I want to pause and thank the men and women who have served in our armed forces. You've stood in the gap, sacrificed comfort, and protected freedom. We honor you, and we're grateful for your courage and service. Today's shout-out goes to Clarence Campbell from Burton, MI. Your commitment through Project23 helps deliver God's Word daily with clarity and conviction. This one's for you. Our text today is Judges 12:4-6. Then Jephthah gathered all the men of Gilead and fought with Ephraim. And the men of Gilead struck Ephraim, because they said, "You are fugitives of Ephraim, you Gileadites, in the midst of Ephraim and Manasseh." And the Gileadites captured the fords of the Jordan against the Ephraimites. And when any of the fugitives of Ephraim said, "Let me go over," the men of Gilead said to him, "Are you an Ephraimite?" When he said, "No," they said to him, "Then say Shibboleth," and he said, "Sibboleth," for he could not pronounce it right. Then they seized him and slaughtered him at the fords of the Jordan. At that time 42,000 of the Ephraimites fell. — Judges 12:4-6 When the conflict between Jephthah and Ephraim escalated, it turned into full-blown civil war. At the Jordan River, the Gileadites set up a simple test: say the word "Shibboleth." Here's why that word mattered: Ephraimites had a regional accent. They couldn't pronounce the "sh" sound and instead said "Sibboleth." A single letter—one tiny sound—became the marker of life or death. If you failed the test, you were executed on the spot. Forty-two thousand brothers died—not because of a true enemy, but because of pride and petty rivalry. It's heartbreaking. Israel was supposed to be one people under God, fighting enemies together. Instead, they killed each other over accents. What began as wounded pride ended in a river of blood. Pride still divides God's people today. Churches split over style. Families fracture over opinions. Christians criticize each other over minor disputes. Small "Shibboleths" become battle lines, and the mission of God suffers. Pride takes small differences and makes them deadly; humility sees the bigger mission and fights the right battles. On Veterans Day, we remember men and women who laid down comfort and safety to protect unity, freedom, and peace. They remind us of what happens when courage is used to defend, not divide. Veterans stood shoulder to shoulder for something greater than themselves. That's what we're called to in Christ—not uniformity, but unity under His mission. The real enemy isn't your brother or sister in Christ. The real enemy is the sin and pride that sets us against each other. Don't let a "Shibboleth" ruin your relationships. Don't let small differences blind you to the bigger battle. Jesus shed his blood to make us one family—let's not shed each other's blood over accents. ASK THIS: Where am I letting pride make small differences into big divisions? Am I more focused on being "right" than being united in Christ? How can I fight for unity instead of fighting my brothers? DO THIS: Identify one "Shibboleth" in your life—a small difference that's become a point of pride or division. Surrender it to God and choose unity over rivalry. PRAY THIS: Father, forgive me when I let pride divide me from my brothers and sisters. Help me to see that our unity in Christ matters more than petty differences. Keep me from fighting the wrong battles and use me to build peace in Your family. Amen. PLAY THIS: "Make Us One."

Matthew 14:7

BIBLE IN TEN

Play Episode Listen Later Nov 10, 2025 6:14

Monday, 10 November 2025 Therefore he promised with an oath to give her whatever she might ask. Matthew 14:7 “Whence with an oath He assented to give her what if she should ask” (CG). In the previous verse, it was noted that Herod had a birthday celebration and that Herodias' daughter danced for him, pleasing him. Matthew continues the narrative, saying, “Whence with an oath He assented to give her what if she should ask.” The word that confirms the oath is homologeó, to assent. It signifies “to voice the same conclusion” (HELPS Word Studies). What is probably intended is affirming a matter by repeating it, a common Hebrew form of speaking, such as, “I vow with a vow to do this thing,” or “Vowing with a vow, he confirmed his word.” In this case, the repetition is seen in the exchange as recorded in lengthier statements in Mark 6 – “And when Herodias' daughter herself came in and danced, and pleased Herod and those who sat with him, the king said to the girl, ‘Ask me whatever you want, and I will give it to you.' 23 He also swore to her, ‘Whatever you ask me, I will give you, up to half my kingdom.'” Herod was enamored with the girl's dancing and wanted to reward her for it publicly, something that would demonstrate his magnanimity to those around him. When assenting to his oath, he binds himself to whatever she asks. It is not a wise way of engaging in gift giving. However, being the king, the one who is offered something with such an oath would not be expected to abuse the request, thus eliciting the disfavor of the king. Life application: In Scripture, people are seen to make vows that can be taken as rash and unwise. A glaring example of this is found in Judges 11 – Then the Spirit of the Lord came upon Jephthah, and he passed through Gilead and Manasseh, and passed through Mizpah of Gilead; and from Mizpah of Gilead he advanced toward the people of Ammon. 30 And Jephthah made a vow to the Lord, and said, “If You will indeed deliver the people of Ammon into my hands, 31 then it will be that whatever comes out of the doors of my house to meet me, when I return in peace from the people of Ammon, shall surely be the Lord's, and I will offer it up as a burnt offering.” 32 So Jephthah advanced toward the people of Ammon to fight against them, and the Lord delivered them into his hands. 33 And he defeated them from Aroer as far as Minnith—twenty cities—and to Abel Keramim, with a very great slaughter. Thus the people of Ammon were subdued before the children of Israel. 34 When Jephthah came to his house at Mizpah, there was his daughter, coming out to meet him with timbrels and dancing; and she was his only child. Besides her he had neither son nor daughter. 35 And it came to pass, when he saw her, that he tore his clothes, and said, “Alas, my daughter! You have brought me very low! You are among those who trouble me! For I have given my word to the Lord, and I cannot go back on it.” Jephthah made a vow that, unfortunately, cost him the life of his daughter. He understood that despite the consequences of his vow, it was one made to the Lord, and it had to be fulfilled. The reason for this story being included in Scripture is to make a point about what God is doing in redemptive history concerning salvation and His favor or rejection of a particular people group. To understand what is going on in that passage, you can refer to the Superior Word sermons on Judges 11. As for our words today, a point made by Jesus and which is repeated by both Paul and James is that when we speak, we are to refrain from making vows concerning such matters. Instead, we are to let our Yes be Yes and our No be No. In other words, when we say we are going to do or not do something, our integrity should be so accepted by others that they know we will perform our word. Additional vows and oaths are unnecessary and will detract from what the Lord expects of us. This does not mean that we are not to make any oath at all. In society, we must swear oaths in court, on legal documents (with our signature, for example), etc. But when speaking, we should refrain from people thinking there is any necessity to go beyond a simply stated affirmation concerning our intent. Lord God, help us to be people of integrity where others can trust our words, taking them at face value. Help us to remember that when we speak, You are being evaluated through the performance and accomplishment of what we say. Help us to remember this and follow through, to Your glory. Amen.

Building a Billion-Dollar Biotech Legacy with Roberto Bellini of BSQUARED Capital

Tank Talks

Play Episode Listen Later Nov 5, 2025 48:50

In this episode of Tank Talks, host Matt Cohen sits down with Roberto Bellini, Co-Founder of BSQUARED Capital and former CEO of Bellus Health, for a powerful conversation about family, legacy, and resilience in the world of biotech.Originally recorded just two weeks before the passing of his father, Dr. Francesco Bellini, one of the founding giants of Canadian biotech, this re-recorded episode serves as a moving tribute to the man known as “Mr. Biotech Canada.” Roberto opens up about what it was like growing up under the guidance of such a visionary figure and how that experience shaped his own path as an entrepreneur and leader.He reflects on the highs and lows of leading Bellus Health, from moments of near collapse to its remarkable $2 billion acquisition by GSK, sharing lessons on risk-taking, perseverance, and the importance of staying grounded through uncertainty. Roberto also offers his perspective on the future of Canadian biotech, highlighting the need for stronger late-stage funding and how BSquared Capital is helping to cultivate the next generation of innovators.This episode isn't just about business success; it's about honoring a legacy, learning through adversity, and discovering what it truly means to build something that endures.The Legacy of Dr. Francesco Bellini (00:02:52)* Francesco Bellini's incredible immigrant story: from arriving in Canada with nothing to a $6B biotech exit.* Business was the family's dinner table conversation, and attending AGMs as a child.* The founding of Biochem Pharma and the discovery of the groundbreaking HIV treatment.* “He was a visionary... he saw things before other people saw them.”Growing Up in Biotech (00:06:30)* Roberto's early memories of board meetings and dinner-table business lessons* How being “in the room” shaped his entrepreneurial mindset* Watching a $6B biotech deal become part of family historyThe Rise, Fall, and Rebirth of Bellus Health (00:08:27)* Roberto's journey from family office analyst to a 30-year-old, first-time CEO of a public company.* The devastating failure of the phase three trial for a rare kidney disease.* Inside a Biotech Failure: The intense, weekend-long “war room” process of unblinding clinical trial data and preparing for a public announcement.The Second Act: Finding the Cough Drug (00:13:47)* Discovering a promising molecule through the NeoMed Institute* Betting the company's future on a last-chance asset* Raising $20M when no one believed and turning it into a $2B successNegotiating the GSK Deal (00:24:45)* The strategic shift from “build-to-sell” to “build-to-scale”, positioning the company for a premium acquisition.* The M&A Playbook: Why you should never lead with a desire to sell; the importance of building for independence.* The high-stakes negotiation with GSK: going from an $11 offer to $14.75, almost losing the deal, and the “mellow tone” that saved it.* The entrepreneur's dilemma: “Every single entrepreneur I've met that sold their company, there's always a moment of not wanting to do it.”Building Canada's Biotech Future (00:30:11)* Why Canada has the innovation but lacks the enduring biotech giants.* The critical gap: The need for more late-stage capital and the role of Canadian pension funds.* The “Gilead of the North” vision: Creating a virtuous cycle of capital, entrepreneurs, and translational science.* Upcoming trends: The convergence of AI and drug discovery to de-risk development and lower costs.Beyond the Lab: Leadership, Risk, and Legacy (00:46:20)* Learning to embrace risk and find joy in reinvention* The best advice from Dr. B: “Spend your money, it'll make you want to earn more.”* Why true success isn't just building a company, but building peopleAbout Roberto BelliniFounder & Managing Partner, BSQUARED CapitalRoberto Bellini is a second-generation biotech entrepreneur and investor. As the former CEO of Bellus Health, he led the company's dramatic turnaround and eventual $2 billion acquisition by GSK. Drawing on his deep operational experience in drug development, he now co-manages BSQUARED Capital, a family office focused on investing in and supporting promising biotech ventures. He is a passionate advocate for building a stronger, more resilient biotech ecosystem in Canada.Connect with Roberto Bellini on LinkedIn: https://www.linkedin.com/in/robertobellini/Visit BSQUARED Capital Website: https://bsq-c.com/Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1Visit the Ripple Ventures website: https://www.rippleventures.com/ This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit tanktalks.substack.com

Stop Bargaining with God | Judges 11:29-31

god jesus christ lord spirit bible holy spirit victory identify amen his spirit gilead manasseh jephthah ammonites bargaining god judges your spirit mizpah

Play Episode Listen Later Nov 5, 2025 3:37

Welcome to The Daily, where we study the Bible verse by verse, chapter by chapter, every day. Today's shout-out goes to Jeff Grasty from Rock Hill, SC. Thank you for your partnership with us through Project23. Our text today is Judges 11:29-31. Then the Spirit of the Lord was upon Jephthah, and he passed through Gilead and Manasseh and passed on to Mizpah of Gilead, and from Mizpah of Gilead he passed on to the Ammonites. And Jephthah made a vow to the Lord and said, "If you will give the Ammonites into my hand, then whatever comes out from the doors of my house to meet me when I return in peace from the Ammonites shall be the Lord's, and I will offer it up for a burnt offering." — Judges 11:29-31 Here is that terminology again: "the Spirit of the Lord clothed Jephthah." Meaning God himself equipped him with power for the battle. Victory was already guaranteed because God was already present. But Jephthah didn't rest in that assurance. He made a vow—an unnecessary bargain with God. This was the irony: the Spirit of God was enough, yet Jephthah bartered like it wasn't. Jephthah complicated his doubt with a detrimental bargain. We are all guilty of this. God gives us the Holy Spirit, the very presence and power that raised Jesus from the dead. Yet instead of moving forward in faith, we add conditions. We say, "God, if you show up, I'll be faithful. If you bless me, then I'll obey. If you fix this, then I'll finally trust You." When he already lives within us. But bargaining with God is not faith—it's fear dressed up as faith. It reveals our insecurity more than our devotion. The Spirit of God already provides everything we need for life and godliness (2 Peter 1:3). Remember, when you add conditions, you don't secure more of God's favor—you forfeit the peace of trusting Him. The Spirit is enough. Always has been. Always will be. So identify where you've been making deals with God, and instead act in simple, Spirit-led obedience. ASK THIS: Where am I complicating God's promises with my own conditions? How am I bargaining with God instead of simply believing Him? What step of faith could I take today to show I trust His Spirit is enough? DO THIS: Stop adding fine print to God's promises. Identify one area where you've been making deals with God, and instead act in simple, Spirit-led obedience. PRAY THIS: Lord, forgive me for complicating what You've already completed. Help me to rest in Your Spirit, trust Your promises, and move forward in bold faith without bargaining. Amen. PLAY THIS: "Same Power."

455. The Road to Gilead with Neil Datta