Podcast appearances and mentions of will chou

Dr. Will Chou, President and CEO of Passage Bio, is developing gene therapies for neurodegenerative diseases, with their lead product being PBFTO2, an AAV gene therapy for a specific genetic variant of frontotemporal dementia. They are also exploring the potential of raising progranulin levels to help patients with other neurodegenerative diseases. Passage Bio's gene therapy, utilizing AAV as the vector, is delivered through an ICM injection into the cisterna magna, bypassing the blood-brain barrier. Will explains, "What we're doing is a little unique. We are starting in the normal way gene therapies approach this, which is we have a patient population with a specific genetic deficiency. They have frontotemporal dementia caused by a mutation in the granulin gene, in the GRN gene, which means they are deficient in creating a protein called progranulin. Our gene therapy product replaces that progranulin, and by replacing what they don't have enough of, we hope to stop the neurodegenerative decline from this disease." "But what is interesting about progranulin is that a growing amount of research shows that progranulin and raising progranulin in general can be neuroprotective across other neurodegenerative diseases as well. We will be pursuing this progranulin-raising one-time gene therapy, not just in patients who have that specific genetic deficiency in the GRN gene. Also, in other patients, such as patients with ALS and patients with other gene deficiencies with FTD where progranulin and raising progranulin could help their neurodegeneration. So in that way, this is a unique approach to gene therapy. Usually, you have one product and can only help a limited group of patients. Here we're looking to use the single product and try and help multiple populations of patients with neurodegenerative disease." #PassageBio #GeneticMedicines #NeurodegenerativeDiseases #AAVs #FrontotemporalDementia #Progranulin #GRNGene passagebbio.com Download the transcript here

Dr. Will Chou, President and CEO of Passage Bio, is developing gene therapies for neurodegenerative diseases, with their lead product being PBFTO2, an AAV gene therapy for a specific genetic variant of frontotemporal dementia. They are also exploring the potential of raising progranulin levels to help patients with other neurodegenerative diseases. Passage Bio's gene therapy, utilizing AAV as the vector, is delivered through an ICM injection into the cisterna magna, bypassing the blood-brain barrier. Will explains, "What we're doing is a little unique. We are starting in the normal way gene therapies approach this, which is we have a patient population with a specific genetic deficiency. They have frontotemporal dementia caused by a mutation in the granulin gene, in the GRN gene, which means they are deficient in creating a protein called progranulin. Our gene therapy product replaces that progranulin, and by replacing what they don't have enough of, we hope to stop the neurodegenerative decline from this disease." "But what is interesting about progranulin is that a growing amount of research shows that progranulin and raising progranulin in general can be neuroprotective across other neurodegenerative diseases as well. We will be pursuing this progranulin-raising one-time gene therapy, not just in patients who have that specific genetic deficiency in the GRN gene. Also, in other patients, such as patients with ALS and patients with other gene deficiencies with FTD where progranulin and raising progranulin could help their neurodegeneration. So in that way, this is a unique approach to gene therapy. Usually, you have one product and can only help a limited group of patients. Here we're looking to use the single product and try and help multiple populations of patients with neurodegenerative disease." #PassageBio #GeneticMedicines #NeurodegenerativeDiseases #AAVs #FrontotemporalDementia #Progranulin #GRNGene passagebbio.com Listen to the podcast here

With COVID, I haven't traveled outside the country in almost three years. Now, I know a lot of people who have already traveled to another country in 2021 and 2022 for vacation, but I know people who won't. At least for now, I fall in the latter camp. In the meantime, I can do some... The post Life Lessons I Learned From Traveling Through China & the Philippines appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

This podcast episode dives into the details of what I learned from a book called How to Not Die Alone. The book provides very useful tips and insights about three self-sabotaging tendencies that stop us from succeeding in our love life in the modern world. I believe these tendencies can also be applied to the... The post How to Not Die Alone By Eliminating Self-Sabotage – A Book Summary [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

I promised to finish reading Jimmy O. Yang's book in my last podcast episode, and I did! Here are some additional lessons and entertaining experiences I learned from the book, and how it has affected how I perceive and live life as a child of Asian immigrants myself. This was an entertaining, funny memoir! Like... The post I Finally Finished Jimmy O. Yang's Book on Asian Immigrant Struggles [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

I'm following the theme of popular blogs around the web by posting an annual end-of-year review . However, there's going to be a few twists: I'm going to keep it concise to a just a few major points rather than every little goal since I doubt you want to listen to three hours of talk.... The post End of Year Review of How 2021 (and 2020) Went For Me appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

I was getting into the holiday spirit a few weeks ago when I started hearing buzz about a Netflix Original Rom-Com Christmas film called Love Hard, featuring Asian American Jimmy O. Yang as the romantic lead. And it was the #1 film in the USA for a few days! After loosely following Jimmy's career over the years,... The post Relatable Asian American Experiences & Lessons with Jimmy O. Yang appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

One of the first experiences I had with negotiation tips came from tips I got from people I follow on buying a car at a good price. Here's a bit of what I learned… The best time to buy a car is at the end of a month based on car salesman sales cycles. They're... The post Lessons Learned from the Master FBI Negotiator – Never Split the Difference by Chris Voss [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

In this podcast episode, I pick the brain of Christopher Lau, a man who has made full-time travel through Southeast Asia a reality. Christopher has an interesting story about how he hated his job and life living in the USA and working for a top tech company. He longed to travel, and he made that... The post How to Travel The World For a Living with A Small Following With SeeLauTravel (Christopher Lau) appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

In this podcast episode, I discuss the stories of the first two coaching clients I've had. They came from different backgrounds and had different goals, but I enjoyed both experiences. And I'm happy for how I was able to help them. The first student cared about improving his personal brand online. He wanted to grow... The post How I Coached Two People to Help Them Grow an Online Following & Progress in Their Careers appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

Kevin Hart went from college drop out to international super star. He's someone who has achieved a monumental, rare level of financial and career success in the stand-up comedy and acting world. I was curious about his journey to see if there's anything we can take from his life to better our own. Based on... The post Kevin Hart's 10 Rules for Success appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

Digital marketing is one of the coolest industries to ever come out. It's fresh, new, and part of the new digital era. I know there's a lot of young, new graduates following my content, and I want to give you some tips from someone experienced on getting your first foot in the door in this... The post How To Get Your First Digital Marketing Job with Seth Jared Hymes [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

I'm a huge fan of escape rooms, and a few years ago, I came across an escape room experience like no other. The lobby, like the escape rooms were well decorated, almost as if you were in a mansion. Everything from the fur carpets to the optical illusions in the paintings made even the waiting... The post Ginger Flesher-Sonnier – From Math Teacher to Multi-Million Dollar Event Empire [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

After hearing a lot of buzz about this book Can’t Hurt Me from young men, I finally gave it a shot after wanting to improve my pull-up count. I usually avoid “tough guy” books in this realm, like Extreme Ownership by Jocko Willink, because I have no desire to join the army or put myself... The post Can’t Hurt Me by David Goggins: Book Summary and Review appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

I got a few of the same type of questions from my YouTube subscribers. They want to know how they can stop caring about what others think. This struggle is a popular issue for most people, so I thought I’d summarize some of the major findings I’ve discovered from it over my own research, experience,... The post How to Stop Worrying What Others Think About You appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

With all the current events regarding #StopAsianHate going on, I figured it was my duty to post about it and support the movement. In this podcast episode, I do a recap on the rise in violence targeting the Asian-American Pacific-Islander (AAPI) community based on what I found out about it, my thoughts, and the different... The post Let’s Talk About #StopAsianHate and Equality appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

In this podcast episode, I wanted to have a discussion on why some businesses fail and others succeed. While there are various people discussing this content already online and offline, I hoped to add some level of unique contribution or debate about this topic given my several years of reading successful business books (and consuming other forms... The post Why Some Businesses Fail While Others Succeed appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

It doesn’t take a rocket scientist to realize that sometimes, your emotions make you make stupid moves. For me, anger is one that comes to mind. When you’re angry, you react, yell, and argue back. Unfortunately, these behaviors may not be the best behavior for a situation, which may only make things worse. Our emotions... The post How To Better Manage Your Emotions and Stay Calm (with Recommended Books) [Podcast] appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

Recently, an email newsletter subscriber asked me how to destress, relax, and cope with anxiety. Rather than give a quick answer, I took my time to make an entire podcast episode on the most effective techniques for relaxing. This topic’s relevant for almost anyone trying to succeed since everyone deals with nervousness and stress at... The post 5 Science-Backed Relaxation Techniques for Stress and Anxiety appeared first on Will Chou's Personal-Development Blog - Motivational Life Advice.

For today's episode, I had Will Chou on the show. He's a Pokemon Card investor, blogger, podcaster, Pokemon Go-er and TikTok-er! Here are a few of the topics we covered: - Most surprising Pokemon GO user demographic - Profiting with Pokemon - Getting a PSA 1! How to find Will: IG: @noexcuseswill TikTok: @willchou Blog: https://willyoulaugh.com Podcast: https://podcasts.apple.com/us/podcast/will-chous-personal-development-podcast-archive/id1330679398

Will Chou comes on the show for a great episode about Asian representation in media, fitness, til tok, and music. You can check will out on IG: @noexcuseswill and his podcast: Willyoulaugh.com/podcast

Will Chou of Will You Laugh shares 5 tips on networking with charisma at a conference or convention. This is part 2 of 2. Episode 797: [Part 2] 5 Tips on Networking With Charisma at a Conference or Convention by Will Chou of Will You Laugh Will Chou shares the lessons he learns from the most successful people and businesses in the world. The original post is located here: and 

Will Chou of Will You Laugh shares 5 tips on networking with charisma at a conference or convention. This is part 1 of 2. Episode 796: [Part 1] 5 Tips on Networking With Charisma at a Conference or Convention by Will Chou of Will You Laugh Will Chou shares the lessons he learns from the most successful people and businesses in the world. The original post is located here: and  Gusto is making payroll, benefits, and HR easy for small businesses. Get 3 months free once you run your first payroll with our link:

Will Chou shares how he leveraged LinkedIn to talk to hundreds of professionals. This is part 2 of 2.    Episode 743: [Part 2] How I Leveraged LinkedIn To Talk to Hundreds of Professionals by Will Chou with KristinWong.com   Kristin Wong is a freelance writer and journalist who writes for Lifehacker, Mentalfloss, and New York Magazine. She frequently covers travel, personal finance, and human behavior.  Kristin launched her own blog, , to write about life as a work-from-anywhere freelancer. She aims to help other creative entrepreneurs navigate the tricky world of freelancing, from managing money to traveling the world to staying productive and getting stuff done. Kristin is a self-professed money geek and is slated to publish a book about personal finance in March of 2018.   The original post is located here:   and 

Will Chou shares how he leveraged LinkedIn to talk to hundreds of professionals. This is part 1 of 2.    Episode 742: [Part 1] How I Leveraged LinkedIn To Talk to Hundreds of Professionals by Will Chou with KristinWong.com   Kristin Wong is a freelance writer and journalist who writes for Lifehacker, Mentalfloss, and New York Magazine. She frequently covers travel, personal finance, and human behavior.  Kristin launched her own blog, , to write about life as a work-from-anywhere freelancer. She aims to help other creative entrepreneurs navigate the tricky world of freelancing, from managing money to traveling the world to staying productive and getting stuff done. Kristin is a self-professed money geek and is slated to publish a book about personal finance in March of 2018.   The original post is located here:   and 

Welcome back to another episode of More Than Marketing. I’m looking forward to this one. I’m your host Arsham Mirshah. I’m here with Will Chou today. True to the name of More Than Marketing, we’ll talk about some marketing stuff but Will here, I got a lot of respect for him. He’s a young, hungry […]

Many Asian men suffer from deep, toxic shame that stops them from really connecting with women and other people. Shame is the feeling of “not being good enough”, and this feeling can be deeply embedded in an Asian man’s psyche due to our upbringing. *** MAIN POINTS *** 00:30 – How connecting with people in real-life is Read more about FAM 037: Will Chou (3/3) – How to heal the shame that binds you[…] The post FAM 037: Will Chou (3/3) – How to heal the shame that binds you appeared first on Asian Guy Transformation.

Lots of Asian men do not like who they are and are not surrounded by people that uplift them. Learn how to become a better Asian man who believes in his worth and has better relationships. *** MAIN POINTS *** 00:50 – How to feel worthy as an Asian man 02:09 – A trap to NOT fall Read more about FAM 036: Will Chou (2/3) – How to become a better Asian man[…] The post FAM 036: Will Chou (2/3) – How to become a better Asian man appeared first on Asian Guy Transformation.

Asian men tend to struggle with being happy due to our programming. Learn how to turn the tides against negativity and start enjoying life. *** MAIN POINTS *** 00:40 – Will’s story of struggle as an Asian-American millennial male and how he got into self-development 03:30 – Why so many Asian guys suffer from unhappiness and low Read more about FAM 035: Will Chou (1/3) – How to be happy as an Asian guy[…] The post FAM 035: Will Chou (1/3) – How to be happy as an Asian guy appeared first on Asian Guy Transformation.

Guest author Will Chou with Kristin Wong shares how to thrive at work when you're an introvert. This is Part 2 of 2. Episode 329: How to Thrive at Work When You're an Introvert - Part 2 by Will Chou with The Wild Wong (Leveraging Strengths). Kristin Wong is a freelance writer and journalist who writes for Lifehacker, Mentalfloss, and New York Magazine. She frequently covers travel, personal finance, and human behavior. Kristin launched her own blog, www.thewildwong.com, to write about life as a work-from-anywhere freelancer. She aims to help other creative entrepreneurs navigate the tricky world of freelancing, from managing money to traveling the world to staying productive and getting stuff done. Kristin is a self-professed money geek and is slated to publish a book about personal finance in March of 2018. The original post is located here:  and  This episode is proudly sponsored by DesignCrowd! Get $100 off your first design project with the coupon code OPTIMAL: 

Guest author Will Chou with Kristin Wong shares how to thrive at work when you're an introvert. This is Part 1 of 2. Episode 328: How to Thrive at Work When You're an Introvert - Part 1 by Will Chou with TheWildWong.com (Quiet Mind). Kristin Wong is a freelance writer and journalist who writes for Lifehacker, Mentalfloss, and New York Magazine. She frequently covers travel, personal finance, and human behavior. Kristin launched her own blog, www.thewildwong.com, to write about life as a work-from-anywhere freelancer. She aims to help other creative entrepreneurs navigate the tricky world of freelancing, from managing money to traveling the world to staying productive and getting stuff done. Kristin is a self-professed money geek and is slated to publish a book about personal finance in March of 2018. The original post is located here:  and  StartEngine is a leading equity crowdfunding site that allows you to raise capital for your business directly from customers, fans, and users. Get 20% off all set up and marketing services: