Podcasts about AAV

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Best podcasts about AAV

Latest podcast episodes about AAV

Locked On Giants – Daily Podcast On The San Francisco Giants
SF Giants interested in Japanese RHP Kodai Senga

Locked On Giants – Daily Podcast On The San Francisco Giants

Play Episode Listen Later Nov 15, 2022 29:38


Are the San Francisco Giants going to replace Carlos Rodón with Japanese righty Kodai Senga? At the very least, it appears that the Giants are courting Senga, as Marc Delucchi snapped a photo of the Oracle Park scoreboard with a photoshopped image of Senga in a Giants uniform on it. Senga is predicted to receive a four- or five-year deal for around $14M to $15M per year. Senga features an upper-90s (sometimes triple-digit) fastball and a plus splitter. The description of Senga as a pitcher should remind San Francisco Giants fans of Kevin Gausman. If that's the case, it should come as no surprise that the SF Giants are interested. Joc Pederson's qualifying offer decision is due today. Carlos Rodón's is too, but his is a much easier call. Pederson must decide whether or not to return to the Giants on a one-year, $19.65M deal. It's possible that Pederson could get more guaranteed money from another team (say 3/$36M), but he won't come close to about $20 million in average annual value. So: will Pederson prefer the higher AAV and a chance to re-enter the market next offseason without the qualifying offer attached to his free agency, or will he seek the most guaranteed money? That decision must be made this afternoon. If the SF Giants miss out on Aaron Judge, are Joey Gallo or Michael Conforto possible fits in the outfield? They may be, but they're not even close to being on the same level as Judge. Gallo is a three true outcomes machine, as most of the time he either strikes out, walks, or homers. Conforto missed all of last season with a shoulder injury. Brandon Nimmo and Kevin Kiermaier are possible fits in the outfield as well if the Giants don't sign Judge. But if they miss out on Aaron Judge, they'll need to pivot to the top shortstop options like Carlos Correa and Trea Turner. Find and follow Locked On Giants on your favorite podcast platforms:

Locked On Giants – Daily Podcast On The San Francisco Giants
Should the SF Giants prioritize Carlos Rodón, or short-term alternatives like Jacob deGrom and Justin Verlander?

Locked On Giants – Daily Podcast On The San Francisco Giants

Play Episode Listen Later Nov 9, 2022 28:07


Just like last offseason, the San Francisco Giants are faced with whether or not to bring back a free-agent ace. Carlos Rodón re-enters the market after one season with the SF Giants, and there's good chance the Giants let him walk just like they did with Kevin Gausman. ESPN and FanGraphs predict Rodón to receive a five-year deal worth about $25 million per year (about $125 million in total). That's very similar to the 5/$110M deal Kevin Gausman received from the Blue Jays last offseason. If the San Francisco Giants choose to let Rodón get his big deal from another team, what should they do? They've been clear that they intend to pair Logan Webb with another top-of-the-rotation arm. Even after letting Gausman leave, the Giants managed to replace his production beautifully in the form of Rodón, who got the same AAV as Gausman but over far fewer years. The alternatives on the market include Jacob deGrom, who's expected to land a short-term deal worth $40+ million, Justin Verlander, who's expected to come in around 2/$70 million, and Clayton Kershaw, who may be willing to accept a one-year deal but almost certainly wouldn't sign with the San Francisco Giants. Among those options, Verlander may be the most appealing because it's a nice middle ground between the absurd AAV deGrom may command and the five-plus years Rodón may command. Find and follow Locked On Giants on your favorite podcast platforms:

Locked On Senators - Daily Podcast On The Ottawa Senators
Ottawa Senators Sign Mark Kastelic To Contract Extension Ahead Of Hosting The Minnesota Wild

Locked On Senators - Daily Podcast On The Ottawa Senators

Play Episode Listen Later Oct 27, 2022 42:32


It's an Ottawa Senators Game Day, up against the Minnesota Wild at home! Brandon Piller and Ross Levitan get you all set for this matchup with Look Out and Locked On players and Keys to victory. Get a house in Ottawa Kasty! Mark Kastelic gets rewarded for his strong play with a two year contract extension with an AAV of $835,000. And the Belleville Senators win 3-2 over the Laval Rocket with Egor Sokolov scoring with first of the season and adding two assists as well. Check us out on TWITTER and YOUTUBE! Support us by supporting our sponsors! Shawarma Palace Ottawa's Favourite Shawarma Since 97 • Six Ottawa locations • Authentic and delicious flavours • The only palace for Shawarma. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

OIS Podcast
The Game Changer

OIS Podcast

Play Episode Listen Later Oct 26, 2022 55:01


Ram Palanki, PharmD, VP of commercial strategy and operations for REGENXBIO, has been involved in the development and launch of at least two groundbreaking treatments: Lucentis (ranibizumab, Genentech/Roche) and Macugen (pegaptanib).If all goes well in clinical trials, Dr. Palanki could soon add one more to his extensive CV: a one-time gene therapy designed to treat age-related macular degeneration and diabetic retinopathy (DR). A master of back-of-the-eye product development and commercialization, Dr. Palanki sits down with OIS podcast host Firas Rahhal, MD, to discuss the history of retinal disease treatments and the potential of gene therapy to address early- and later-stage disease.He hopes REGENXBIO's lead product, RGX-314, helps resolve the adherence issues that plague anti-VEGF drugs, the current standard of care. Currently in Phase III trials, RGX-314 introduces a trans gene that can encode for a therapeutic protein for life—a concept REGENXBIO is exploring for the first time. Clinical trials also show a potential benefit for DR. Interim data show about 50% of patients demonstrated a two-step or greater improvement in visual acuity from baseline at six months after a single dose.            Listen to the podcast today to hear Dr. Palanki and Dr. Rahhal discuss: What it was like to be involved in the groundbreaking Lucentis and Macugen launches.How REGENXBIO plans to solve the sustainability problem that arose with the advent of anti-VEGF therapies.The history, mechanism of action, and route of administration behind RGX-314, REGENXBIO's lead program.The strength of RGX-314's adeno-associated viral vector (AAV) and other novel AAV vectors (NAV) technology platform.The philosophy behind REGENXBIO's DR program, including the potential of treating healthy eyes with RGX-314.How Dr. Palanki's responsibilities differ between development and commercialization. Click “play” to listen.

Locked On Flames - Daily Podcast On The Calgary Flames
Dan Vladar Signs 2-Year Extension

Locked On Flames - Daily Podcast On The Calgary Flames

Play Episode Listen Later Oct 21, 2022 24:45


Goaltender Dan Vladar has signed an extension with the Calgary Flames. 2 year deal at $2.2m AAV starting next season. The goaltender has had a strong start to his second NHL season. Why would the team trade him when they can move their goalie development forward by keeping him around? Plus, Darryl Sutter is giving him a rather tall task with increasing his workload. Plus a quick preview of tonight's game. Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKEDON15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! SimpliSafe With Fast Protect™️ Technology, exclusively from SimpliSafe, 24/7 monitoring agents capture evidence to accurately verify a threat for faster police response. There's No Safe Like SimpliSafe. Visit SimpliSafe.com/LockedOnNHL to learn more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Golden Knights - Daily Podcast On the Vegas Golden Knights
Nic Hague signs a three-year extension at the 11th hour as VGK is set to open against the Kings

Locked On Golden Knights - Daily Podcast On the Vegas Golden Knights

Play Episode Listen Later Oct 11, 2022 44:04


Nic Hague is a Restricted Free Agent no longer. On Monday, VGK signed Hague to a three-year extension worth about $2.3 million AAV. Hague traveled with the team to L.A. on Friday, but will not be in uniform in the season opener. We preview the Los Angeles Kings and feel this will be a difficult game on the road to start season 6 in Las Vegas. We also have some predictions for the upcoming season. Learn more about your ad choices. Visit podcastchoices.com/adchoices

PaperPlayer biorxiv neuroscience
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Oct 7, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.05.509883v1?rss=1 Authors: Reimann, R. R., Puzio, M., Rosati, A., Emmenegger, M., Schneider, B. L., Valdes, P., Huang, D., Caflisch, A., Aguzzi, A. Abstract: The cellular prion protein PrPC mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody-derived ligands against the globular domain of PrPC (GDL) can also initiate neurotoxicity by inducing an intramolecular R208-H140 hydrogen bond (H-latch) between the alpha2-alpha2 and beta2-alpha2 loops of PrPC. Importantly, GDL that suppress the H-latch prolong the life of prion-infected mice, suggesting that GDL toxicity and prion infections exploit convergent pathways. To define the structural underpinnings of these phenomena, we transduced nineteen individual PrPC variants to PrPC-deficient cerebellar organotypic cultured slices using adenovirus-associated viral vectors (AAV). We report that GDL toxicity requires a single N-proximal cationic residue (K27 or R27) within PrPC. Alanine substitution of K27 also prevented the toxicity of PrPC mutants that induce Shmerling syndrome, a neurodegenerative disease that is suppressed by co-expression of wild-type PrPC. K27 may represent an actionable target for compounds aimed at preventing prion-related neurodegeneration. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Locked On Stars - Daily Podcast On The Dallas Stars
What Jason Robertson's New Contract Means for the Dallas Stars

Locked On Stars - Daily Podcast On The Dallas Stars

Play Episode Listen Later Oct 6, 2022 27:18


Jason Robertson has reached a new 4-year deal with the Dallas Stars worth $7.75 million AAV. The Stars finally have their premiere goal-scorer back for the 2022-2023 season. What does this mean for the Dallas Stars organization? Will he be placed back on a line with Roope Hintz and Joe Pavelski? Will another young forward lose a chance to make the roster because of his return? How does the new contract effect the Stars standing in the eyes of the rest of the hockey community? We talk about all of this and more on today's episode! Subscribe to Locked on Stars on YouTube: https://www.youtube.com/c/LockedOnStars Follow Dane on Twitter: https://twitter.com/Dane__Lewis Follow the show on Twitter: https://twitter.com/LockedOnStars Follow the show on Instagram: https://www.instagram.com/lockedonstars/ Find Locked on Stars on you Favorite Podcast Platform: Apple: https://tinyurl.com/3wjnbvp2 Spotify: https://tinyurl.com/2p9yx4ur Google: https://tinyurl.com/2yc492b7 Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

PaperPlayer biorxiv neuroscience
Spatial proteomics and iPSC modeling uncover mechanisms of axonal pathology in Alzheimer's disease

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Oct 3, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.30.510408v1?rss=1 Authors: Cai, Y., Kanyo, J., Wilson, R., Mansuri, M. S., Cardozo, P. L., Goshay, D., Tian, Z., Braker, A., Trinh, H. K., Lam, T., Brennand, K., Nairn, A. C., Grutzendler, J. Abstract: Amyloid deposits in Alzheimer's disease (AD) are surrounded by large numbers of plaque-associated axonal spheroids (PAAS). PAAS disrupt axonal electrical conduction and neuronal network function, and correlate with AD severity. However, the mechanisms that govern their formation remain unknown. To uncover the molecular architecture of PAAS, we applied proximity labeling proteomics of spheroids in human AD postmortem brains and mice. We then implemented a human iPSC-derived AD model recapitulating PAAS pathology for mechanistic studies. Using this strategy, we uncovered hundreds of previously unknown PAAS-enriched proteins and signaling pathways, including PI3K/AKT/mTOR. Phosphorylated mTOR was highly enriched in PAAS and strongly correlated with disease severity in humans. Importantly, pharmacological mTOR inhibition in iPSC-derived human neurons or AAV-mediated knockdown in mice, led to a marked reduction of PAAS pathology. Altogether, our study provides a novel platform to examine mechanisms of axonal pathology in neurodegeneration and to evaluate the therapeutic potential of novel targets. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Rocket Sports Radio
Spotlight on Slafkovsky | Canadiens Connection ep 211

Rocket Sports Radio

Play Episode Listen Later Oct 1, 2022 100:32


This Week's ShowSegment 1: Week in Review, Habs News, League NewsCheck out news Headlines posts at http://allhabs.net/ (AllHabs.net).  Nick Suzuki and Madison Bowey were full participants for Saturday's practice. Josh Anderson returned to practice after recovering from a hand injury. Twenty-three players were cut from Canadiens training camp on Friday. Laval Rocket training camp will open on Sunday. Canadiens signed goaltender Jake Allen to a two-year contract extension with an AAV of $3.85 million. Be sure to read the content at https://ahl.report/ (AHL.report) and check out https://www.thepresszone.fm/ (The Press Zone - Montreal). Quotes of the week from Kent Hughes, Jeff Gorton and Adam Nicholas. Hockey news and notes: Jeff Petry was fined $5,000 by NHL Department of Player Safety. Nashville Predators will play SC Bern in an exhibition game in Switzerland on Monday. Mitch Marner could be used as defenseman for Maple Leafs this season. The 50th anniversary of the 1972 Summit Series victory was celebrated. Segment 2: BIG Topic - It's still early but there are rumblings of concern about the play of first overall pick Juraj Slafkovsky. The 18-year-old has not yet scored in a Canadiens jersey which includes two games at the Prospects Challenge and two exhibition games.. The Canadiens training camp roster has been trimmed and more cuts are on the way. With just over a week until the start of the regular season, who will make the Canadiens opening night roster? Michael and Rick reveal their early selections of forwards, defenceman and goaltenders that could start the season in Montreal. Which rookie will find his way into the lineup? Segment 3: Have Your SayCanadiens upcoming events. Canadiens Connection Question of the Week. Listener's texts and emails. Canadiens Connection on Rocket Sports RadioCanadiens Connection is hosted by Rick Stephens (http://www.twitter.com/allhabs (@AllHabs)) with Michael Spinella (https://twitter.com/Thespinella (@TheSpinella)), Amy Johnson (https://twitter.com/flyersrule (@FlyersRule)) and Chris G (https://twitter.com/chrishabs360 (@ChrisHabs360)). This talented team of credentialed journalists come together to share their valued insight. Canadiens Connection is a connection between fans, journalists, players, coaches, management to thoroughly discuss their favorite game in an informative, thought provoking, and entertaining way. Get the Canadiens Connection!Be sure to follow @habsconnection on https://twitter.com/HabsConnection (Twitter), https://www.facebook.com/habsconnection/ (Facebook), https://www.instagram.com/habsconnection/ (Instagram) Search for "Canadiens Connection" from Rocket Sports Radio on your favorite podcast app and subscribe! Use our single link below on any device to locate subscription links to major podcast apps. https://canadiensconnection.fm/listen (Subscribe to Canadiens Connection) Share the Canadiens Connection on social media. And we would be grateful for your 5-star rating for the podcast! If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL/IN/LA/MI/NJ/PA/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (CO/NH), 888-789-7777/visit http://ccpg.org/chat (CT), 1-800-BETS OFF (IA), 877-8-HOPENY/text HOPENY (467369) (NY), visit OPGR.org (OR), call/text TN REDLINE 1-800-889-9789 (TN), or 1-888-532-3500 (VA). 21+ (18+ NH/WY). Physically present in AZ/CO/CT/IL/IN/IA/LA(select parishes)/MI/NH/NJ/ NY/OR/PA/TN/VA/WV/WY only. New customer offer void in NH/OR/ONT-CA. $200 in Free bets: New customers only. Valid 1 per new customer. Min. $5 deposit. Min $5 wager. $200 issued as eight (8) $25 free bets. Ends 9/19/22 @ 8pm. Early Win: 1 Early Win Token issued per eligible game. Opt in req. Token expires at start of eligible game. Min moneyline bet $1. Wagering limits apply. Wagers placed on both sides of moneyline will void bet. Ends 1/8/23 @ 8pm ET....

The Athletic Hockey Show: A show about the NHL
John Tortorella's Philadelphia Flyers long season ahead, Spencer Knight signs extension with Florida Panthers & did the St. Louis Blues improve enough this off-season?

The Athletic Hockey Show: A show about the NHL

Play Episode Listen Later Sep 27, 2022 71:01 Very Popular


On the American's edition of The Athletic Hockey Show, Craig and Sean discuss Sean, Dom and Shayna's work on The Athletic's NHL previews, specifically with the St. Louis Blues upcoming season. Plus Craig and Sean provide analysis on the Florida Panthers extending goalie Spencer Knight for three seasons at an AAV of 4.5 million. Charlie O'Connor previews the season for the Philadelphia Flyers, how coach John Tortorella fits in, the injuries to Ryan Ellis and Sean Couturier and how long GM Chuck Fletcher's leash is. Plus the guys answer your questions and respond to your comments in the only segment of the show that really matters, love from the #Tuesdayboyzzz. And, right now, you can get a 6 month subscription to The Athletic for just $1 a month when you visit http://theathletic.com/hockeyshow Learn more about your ad choices. Visit megaphone.fm/adchoices

ScuttlePuck NHL Hockey Podcast
Episode Matt Cooke (398):Author Sean Mitton On the Summit Series. Mike Explains Why Jersey Ads Are Bad.

ScuttlePuck NHL Hockey Podcast

Play Episode Listen Later Sep 25, 2022 81:43


Author Sean Mitton joins us to discuss his new book, "When Canada Shut Down" which tells new stories around the 72 Summit Series. Nathan MacKinnon becomes highest AAV player in NHL. Why jersey ads are so bad.   Listen Here:  iTunes  Google Play  Stitcher  Direct MP3   iHeart Radio Title Player Matt Cooke Feedback  News MacKinnon signs for $12.6MM for 8 years PK Subban, Zdeno Chara and Keith Yandle retire Leafs and Habs show ads for their jerseys and it's as horrible as you might expect Oilers sign Jake Virtanen to PTO to much outcry Sean Mitton interview Guess the 5th Western Conference predictions,  Crazy Stats

Locked On Avalanche - Daily Podcast On The Colorado Avalanche
MacKinnon Inks Deal That Makes Him Highest Paid Player in NHL

Locked On Avalanche - Daily Podcast On The Colorado Avalanche

Play Episode Listen Later Sep 21, 2022 40:19 Very Popular


Nathan MacKinnon himself said he thought a deal between him and the Colorado Avalanche was close. He was right. MacKinnon and the Avalanche agreed on an 8 year, $12.6 million AAV deal which will make him the highest paid player in the league. Surpassing Edmonton superstar Connor McDavid by $100,000. The deal doesn't kick in until next season as MacKinnon plays the final year of his steal contract this coming season. It's a massive contract for one of the league's best players. But will it hamstring the Avs next season as they will need money to sign RFA's Alex Newhook and Bowen Byram. The Avs might have to lay low for a season, but can get right back into the game the following year when the salary cap is expected to go up significantly. A lot to break down here! Tune in and enjoy! BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Stars - Daily Podcast On The Dallas Stars
Where Does Nils Lundkvist Fit on the Dallas Stars Roster?

Locked On Stars - Daily Podcast On The Dallas Stars

Play Episode Listen Later Sep 21, 2022 35:36 Very Popular


On Monday night, the Dallas Stars made a trade for New York Rangers defenseman Nils Lundkvist. The 22-year-old right-hander has only 25 games of NHL experience, but he has plenty of offensive upside that he can provide to the Dallas Stars roster in need of defensive depth. Jon Chik from Locked on New York Rangers joins the show to talk about the trade as well as what we can expect from Lundkvist on the ice. We also talk about the Dallas Stars official training camp roster, which features Jason Robertson. Does this mean anything? When can we expect to see Robo FINALLY sign a new deal with the Stars? To close we discuss Nathan MacKinnon's MASSIVE new deal (worth $12.6 million AAV) and what it means for the Avs and the central division. We also discuss three notable NHL retirement announcements from Zdeno Chara, PK Subban & Keith Yandle Subscribe to Locked on Stars on YouTube: https://www.youtube.com/c/LockedOnStars Follow Dane on Twitter: https://twitter.com/Dane__Lewis Follow the show on Twitter: https://twitter.com/LockedOnStars Follow the show on Instagram: https://www.instagram.com/lockedonstars/ Find Locked on Stars on you Favorite Podcast Platform: Apple: https://tinyurl.com/3wjnbvp2 Spotify: https://tinyurl.com/2p9yx4ur Google: https://tinyurl.com/2yc492b7 Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Athletic Hockey Show: A show about the NHL
Nathan MacKinnon becomes NHL's highest paid player, Zdeno Chara, PK Subban and Keith Yandle retire, Mike Grier's rebuild in San Jose

The Athletic Hockey Show: A show about the NHL

Play Episode Listen Later Sep 20, 2022 71:43 Very Popular


On the season premiere of The Athletic Hockey Show USA with Craig Custance and Sean Gentille, discuss Nathan MacKinnon's monster 8 year extension with Colorado, making him the highest paid player in the NHL with an AAV of 12.6 million a season. The guys celebrate the careers of NHL defensemen Zdeno Chara, P.K. Subban and Keith Yandle who retired from their playing careers on Tuesday and we look back on the NHL's media availability in Vegas with the games top stars and praise MacKinnon and Jonathan Huberdeau who stole the show and Connor McDavid who missed the mark with his vanilla, polarizing comments on the Hockey Canada scandal. Mike Grier the new General Manager in San Jose joins in segment two to discuss the rebuild in San Jose, trading away Brent Burns, the infectious energy of Tomas Hertl, being a trailblazer in hockey as the first black GM in the game and Mike talks about his brother Chris who manages the NFL's Miami Dolphins, and if he is signing Joe Thornton to a PTO. Learn more about your ad choices. Visit megaphone.fm/adchoices

Tim and Friends
It's Retirement Day in the NHL

Tim and Friends

Play Episode Listen Later Sep 20, 2022 93:54


In honour of P.K. Subban, Zdeno Chara, and Keith Yandle retiring, we ask on the show “When I retire, the first thing I would do is ______.” 6-time Olympic medallist Andre De Grasse (39:15) joins the show. Blue Jays Central's Caleb Joseph (27:25) hops on ahead of the Jays taking on the Phillies. Nick Kypreos (50:45) talks retirements and Nathan MacKinnon becoming the highest paid player by AAV in the NHL. Brock Vereen (1:13:18) joins for some football talk.The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Media Inc. or any affiliate.

Oilers NOW with Bob Stauffer
Exploring McDavid and Draisaitl's next contracts (9/20/22)

Oilers NOW with Bob Stauffer

Play Episode Listen Later Sep 20, 2022 19:33


Just how high will the AAV get for Leon Draisaitl and Connor McDavid when their contracts are uop for renewal in a few years time. This in the wake of Nathan MacKinnon becoming the highest-paid player in the salary cap era at $12.6 million per year. Learn more about your ad choices. Visit megaphone.fm/adchoices

Locked On Stars - Daily Podcast On The Dallas Stars
Who is to Blame for the Delay of Jason Robertson's New Contract with the Dallas Stars?

Locked On Stars - Daily Podcast On The Dallas Stars

Play Episode Listen Later Sep 19, 2022 31:24


Today we take look around the NHL to see who is at fault for Jason Robertson STILL being unsigned with the Dallas Stars. While you can certainly look to the Dallas Stars front office for not having a ton of cap space, you can also look around the nHL at other young forwards signing 7-8 year deals worth 7-8 million dollars AAV. Guys like Tim Stützle, Tage Thompson and Jordan Kyrou all have new deals and it likely is making Robertson's camp want as much if not more money than them. We also discuss Wyatt Johnston and Logan Stankoven's performances at the Traverse City prospect tournament as well as Rick Bowness' situation in Winnipeg and why it should make Stars fans more appreciative. Subscribe to Locked on Stars on YouTube: https://www.youtube.com/c/LockedOnStars Follow Dane on Twitter: https://twitter.com/Dane__Lewis Follow the show on Twitter: https://twitter.com/LockedOnStars Follow the show on Instagram: https://www.instagram.com/lockedonstars/ Find Locked on Stars on you Favorite Podcast Platform: Apple: https://tinyurl.com/3wjnbvp2 Spotify: https://tinyurl.com/2p9yx4ur Google: https://tinyurl.com/2yc492b7 Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On NHL - Daily Podcast On The National Hockey League
Hockey Is Back As Prospect Tournaments Begin Around the NHL This Weekend

Locked On NHL - Daily Podcast On The National Hockey League

Play Episode Listen Later Sep 16, 2022 32:01 Very Popular


NHL prospect and rookie tournaments are under way as all 32 teams begin preparation for the 2022-23 season. We cover the six tournaments and discuss some of the top players that will be competing including Juraj Slafkovsky, Simon Nemec, Mason MacTavish and Kent Johnson. Plus Nathan MacKinnon says he is close to signing a new, long-term deal with the Colorado Avalanche but will his AAV exceed Connor McDavid's? We discuss who should be the highest paid player in the NHL. All this and more on today's Locked On NHL Podcast with Rachel Donner and Gil Martin. Support Us By Supporting Our Sponsors! BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Just Baseball Show
306 | The Best High Priced Free Agent Signings Of 2022

The Just Baseball Show

Play Episode Listen Later Sep 13, 2022 73:46 Very Popular


Aram and Peter discuss an Aaron Judge card that sold for $180,000 and take a look at the 10 best high priced free agent signings of 2022 ($15 million+ AAV). Use Code "JUSTBASEBALL" for 15% off your Diet Smoke order Use Code "JustBaseball" for Deposit Match on Prize Picks Get Your Just Baseball Merch! Check out our website: https://www.justbaseball.com/ Personal Twitters: @peterappel23, @jack_mcmullen11, @aramleighton8 Learn more about your ad choices. Visit megaphone.fm/adchoices

Locked On Senators - Daily Podcast On The Ottawa Senators
Interview With Ottawa Senators Prospect Kevin Mandolese + Erik Brannstrom Signs One-Year Extension

Locked On Senators - Daily Podcast On The Ottawa Senators

Play Episode Listen Later Sep 5, 2022 67:37


We have breaking news on today's episode! Brandon Piller and Ross Levitan react to the news that the Ottawa Senators have signed Erik Brannstrom to a one year extension worth $900k AAV. We give our thoughts on why it took so long, what role will he play and more! We also have an interview with Sens goalie prospect, Kevin Mandolese (@KMandolese)! The last time we spoke with Mando was just after he won the QMJHL Goalie of the year award so we catch up on his time in Belleville, playing in the ECHL in Atlanta, recovering from his injury and more! Check us out on TWITTER and YOUTUBE! Support us by supporting our sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKEDON15,” and you'll get 15% off your next order. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Stars - Daily Podcast On The Dallas Stars
What Does Jake Oettinger's New Contract Mean for the Dallas Stars?

Locked On Stars - Daily Podcast On The Dallas Stars

Play Episode Listen Later Sep 2, 2022 30:50 Very Popular


On Thursday afternoon, the Dallas Stars announced a new three-year deal for goaltender Jake Oettinger worth $12 million ($4 million AAV). Oettinger had a great 2021-2022 season and played great against the Calgary Flames in round one of the Stanley Cup Playoffs. What does his deal mean for the Stars? What does it mean for Jason Robertson and his contract negotiations? We also discuss Stars owner Tom Gaglardi and his recent comments on the Cam and Strick podcast. Why should the Dallas Stars pay Jason Robertson what he wants? Why should he (and other Stars executives) take a different approach to discussing Tyler Seguin and Jamie Benn in public? Subscribe to Locked on Stars on YouTube: https://www.youtube.com/c/LockedOnStars Follow Dane on Twitter: https://twitter.com/Dane__Lewis Follow the show on Twitter: https://twitter.com/LockedOnStars Find Locked on Stars on you Favorite Podcast Platform: Apple: https://tinyurl.com/3wjnbvp2 Spotify: https://tinyurl.com/2p9yx4ur Google: https://tinyurl.com/2yc492b7 Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Giants – Daily Podcast On The San Francisco Giants
Do the SF Giants need to re-sign Carlos Rodón?

Locked On Giants – Daily Podcast On The San Francisco Giants

Play Episode Listen Later Aug 30, 2022 30:20 Very Popular


Do the San Francisco Giants need to re-sign Carlos Rodón? The Giants been very good even with Rodón, so it would seem that they'd be setting themselves further back if they don't replace him. The best way for the Giants to replace Carlos Rodón may be for the Giants to bring back ... Carlos Rodón. The Giants' 2023 rotation options are explored. Logan Webb will be eligible for arbitration for the first time, and is under club control for three more seasons. Alex Cobb, Alex Wood, and Anthony DeSclafani have guaranteed deals for 2023. Jakob Junis, who's been a bright spot this season for the Giants, is arbitration eligible for the final time and can be retained for a relatively cheap salary. Free-agent options are discussed. Could the Giants try to sign Jacob deGrom to a short-term, high-AAV deal? Something like two years, $90 million? Or would the Giants be better off spending something like 4/$120M on Rodón? Plenty of options are out there, but Rodón and deGrom are pretty clearly the best available. The Giants should probably sign one of them and also spend aggressively in the position player market, where stars like Aaron Judge and Trea Turner are free agents. Find and follow Locked On Giants on your favorite podcast platforms:

DTD PODCAST
Episode 115: Peter Ostrovsky “Miami Boat Crews/Operation Frozen Timber”

DTD PODCAST

Play Episode Listen Later Aug 29, 2022 177:06


This week in the studio a man who in 1964 was born in South Miami to immigrant parents. His father Russian and his mother Cuban, he was raised in a strict household that taught him, if he wanted to be or do anything in life it was on him to make it happen. Fast forward to 1984 while working as a lifeguard he got to see his first Marijuana bust, and it was at this moment that the hook was set for my guest to become a law enforcement agent, working with Customs on the Miami boat crews, as an undercover detective posing as an international smuggler, leading an investigation into one of the biggest Marijuana and Cocaine trafficking case that the Northwest United States had seen. My guest worked on the Joint Terrorism Task Force and was even the acting Attaché in London, England. This week is not only about my guests amazing career, but also the devastating loss of his son who was killed in a U.S. Marine training incident off of San Clemente Island, where the AAV that he was riding in had a catastrophic failure and sank trapping him inside. My guest has taken this incident and used it to help not only soldiers in the field, but to find and hold those responsible, accountable for their actions. It is my great pleasure and honor to introduce you to Peter Ostrovsky.

Locked On Avalanche - Daily Podcast On The Colorado Avalanche
The Kadri Saga Reaches It's Conclusion

Locked On Avalanche - Daily Podcast On The Colorado Avalanche

Play Episode Listen Later Aug 19, 2022 39:20 Very Popular


In the end, it was likely the term. The Colorado Avalanche said goodbye to a fan favorite yesterday as Nazem Kadri signed a 7 year, $7 million AAV deal with the Calgary Flames. Kadri's patience paid off in the number of years on the deal, while likely taking a little less than he was hoping for. What does this mean for the Avalanche? Well, they have no doubt been preparing for this situation and have a plan B and C ready to go. Just what that is we will have to wait to see. But this without a doubt hurts the Avalanche. Not only was Kadri a fan favorite, but his production is going to be difficult to replicate with what is available on the FA market. Is a trade on the horizon for the Avs? BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Oilersnation Radio
Do the Oilers need to respond to what the Flames have done this offseason?

Oilersnation Radio

Play Episode Listen Later Aug 19, 2022 46:33 Very Popular


It's Thursday afternoon and that means a fresh episode of Oilersnation Radio has wrapped and is here to help you get through what's left of your week. On today's show, we talked about Nazem Kadri signing in Calgary, how that affects the Pacific Division, and a whole lot more.To kick off this week's podcast, we got started with a look at the Calgary Flames after news broke that they had signed Nazem Kadri to a seven-year deal that carries a $7 million AAV. Does bringing in Huberdeau, Weeger, and Kadri make the Flames a contender? Are they even better than they were last year? Seeing as the Flames have avoided the rebuild by bringing in some big pieces, do the Oilers have to find a way to respond, or are they already set? From there, we looked at the rumours that are circling the Edmonton Oilers right now, including their alleged interest in both Patrick Kane and Phil Kessel. As much as it's fun to talk about either guy potentially coming to town, none of us can even understand how the math would work to make it happen. Lastly, we wrapped up this week's podcast with another round of Ask the Idiots and Hot and Cold performers. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins
Should Tristan Jarry be extended this offseason or during the season?

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins

Play Episode Listen Later Aug 11, 2022 32:49 Very Popular


Happy Thursday! Hunter starts off the show by wishing his condolences to Ben Stelter, the young Oilers fan who lost his life due to brain cancer earlier this week before getting into the meat of the episode. After that, he brings up the debate on if the Penguins should wait to extend Tristan Jarry after the season or if they should just get it out of the way now. He looks at his numbers from the past couple of years to see what AAV he could get followed by what he still needs to see in Jarry to feel comfortable about an extension right now. He then gives his stance on it, even though the goalie market next year isn't that good before touching on some Metro power rankings. How do the Penguins currently stack up to the rest of the Metro teams? Are they still squarely a playoff team heading into next season? Which teams have improved vs which teams have not? Finally, Hunter looks at some other pending UFAs on the Penguins and gives his thoughts on if the Penguins should have any extension talks with them. All that, plus much more, on this episode of Locked On Penguins. Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKEDON15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Avalanche - Daily Podcast On The Colorado Avalanche
MacKinnon Asking for Big Bucks? Kadri & Islanders Finalizing Deal? Kuemper & Landeskog Season Grades

Locked On Avalanche - Daily Podcast On The Colorado Avalanche

Play Episode Listen Later Aug 10, 2022 40:48 Very Popular


Nathan MacKinnon is heading into the 2022-2023 season on the last year of the most team-friendly contract in sports. We all know a big pay increase is heading his way but now Adrian Dater is reporting MacKinnon is looking to become the highest paid player in the league. His timing could not be better as the league's salary cap is expected to increase significantly after this coming season. So a record-breaking deal is not out of the question. As for another Avalanche player looking for a his pay day, Nazem Kadri might have found it with the New York Islanders. Rumore is the two sides are finalizing a 7 year $7 million AAV contract. If that is indeed the final amount, why did the Avs not want to go that high for Kadri? Is it the dollar amount, the term, or both? We also hand out season grades for goalie Darcy Kuemper and captain Gabriel Landeskog! Tune in and subscribe! BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

PHNX Arizona Coyotes Podcast
Catching Up With Lawson Crouse

PHNX Arizona Coyotes Podcast

Play Episode Listen Later Aug 10, 2022 50:15


Lawson Crouse and the Arizona Coyotes narrowly avoided arbitration on Monday when the two sides agreed to a 5-year contract extension with a $4.3 million AAV. Crouse joins the show to discuss his extension, his eventful summer, his outlook on the rebuild and more! 0:00 Intro 1:07 Lawson Crouse Jons the show! 2:30 Lawson's engagement 8:30 Liam O'Brien's wedding 11:53 Lawson's offseason at home in Canada 14:47 Why Lawson wanted to stay in Arizona long term 16:35 Inside the contract negotiations and avoiding arbitration 17:45 How Lawson earned this contract extension 19:29 Where Lawson thinks his game needs to improve 20:49 Dose Crouser see himself as a 30-goal scorer? 23:40 Lawson's thoughts on playing at ASU's Tempe arena 26:25 What does the Coyote's future look like over the next few years 28:08 Crouse's thoughts on being a face of the franchise and Arizona sports 29:21 Lawson as a leader on the team 30:55 Could Lawson wear the captain's C next year? 41:26 Thoughts on the terms of Crouse's extension 43:48 The World Juniors and the poor attendance SUBSCRIBE to our YouTube: https://bit.ly/phnx_youtube Website: https://gophnx.com PHNX Locker: https://phnxlocker.com/ Head on over to The PHNX Locker to pick up one of our new PHNX hats! SOCIAL: Twitter: https://twitter.com/PHNX_Coyotes Instagram: https://instagram.com/PHNX_Sports Download the DraftKings Sportsbook app now (https://bit.ly/3Jl1dMX), use promo code PHNX and make your first deposit and get a RISK-FREE BET UP TO ONE THOUSAND DOLLARS. Minimum age and eligibility restrictions apply. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL/IN/MI/NJ/PA/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (CO/NH), 888-789-7777/visit http://ccpg.org/chat (CT), 1-800-BETS OFF (IA), 1-877-770-STOP (7867) (LA), 877-8-HOPENY/text HOPENY (467369) (NY), visit OPGR.org (OR), call/text TN REDLINE 1-800-889-9789 (TN), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/LA/MI/NJ/NY/PA/TN/VA/WV/WY only. Min. $5 deposit required. Eligibility restrictions apply. See http://draftkings.com/sportsbook for details. OGeez! We have free stuff for you! Enter the “Flavoring Life” sweepstakes. One winner will receive 3, YES THREE, bags of OGeez including Orange Creamsicle and Tropical flavors, an OGeez! Hat, a PHNX shirt of your choice and a PHNX annual membership. Sign up at gophnx.com or visit https://docs.google.com/forms/d/e/1FAIpQLSfIplqDYsxYeiotn5Zc6hRahaX0a5qG99eHVzkhOlGZDRdgUA/viewform Check out OGeez! online at ogeezbrands.com and on Instagram @ogeezbrands. You can also find their products at your local dispensary. Must be 21 years or older to purchase. Enter to win the “Toast of the Month” sweepstakes to win a $50 Four Peaks gift card, a PHNX shirt of your choice, and a PHNX annual membership. Go to goPHNX.Com or visit https://docs.google.com/forms/d/e/1FAIpQLSfOabxo8KQxOWwn9wTilMBuTMAJdrL0CaH9lzfuJqgKN9vfSg/viewform FOCO has you covered with the best Arizona Merchandise. They have officially licensed gear for men, women and kids and everything from bobbleheads to swimsuits to crocs. Head on over to foco.com. For all non pre-sale items use the promo code “PHNX” for 10% off Learn more about your ad choices. Visit megaphone.fm/adchoices

Locked On NHL - Daily Podcast On The National Hockey League
Mangiapane's Extension Inked, Klingberg Boosts Ducks Defense, Possible Reverse Retro Rankings

Locked On NHL - Daily Podcast On The National Hockey League

Play Episode Listen Later Aug 3, 2022 54:06 Very Popular


The Calgary Flames were able to ink Andrew Mangiapane's contract and avoid arbitration. The 26 year old winger brings a lot to the team but is it enough to justify the $5.8m AAV for the next three years? Speaking of big contracts, John Klingberg looks to prove himself and earn a long term deal. Brett Holden and Jes Belmosto debate on how much Klingberg brings to the table. Plus! The pair wrap up the episode with ranking round 2 of possible reverse retros. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Let's Go Devils Podcast
Siegenthaler Re-signs With Devils (WOO REPORT EP220)

Let's Go Devils Podcast

Play Episode Listen Later Jul 27, 2022 36:24 Very Popular


Jonas Siegthaler has re-signed with the New Jersey Devils for five years with a AAV of $3.4M.Hosted By Sam Woohttps://pucksandpitchforks.comhttps://www.LetsGoDevils.com#NJDevils #NHL #LetsGoDevils #LGD #Devils #NewJersey #NCAA #AHL

Grant and Danny
MLB All-Star Game ratings, Kyler Murray gets new extension, G&D's Madden ratings

Grant and Danny

Play Episode Listen Later Jul 22, 2022 39:26


7.22.22 Hour 1 1:00- We open up the show discussing Grant's deep slumber from last night, and it's a deep one. Then, we get to the MLB All-Star game and the ratings that it produced on Tuesday.  20:00- Kyler Murray gets a 5 year extension from the Arizona Cardinals, and he is now the 2nd highest paid QB by AAV.  33:05- G&D rant about Madden ratings and how they mean absolutely nothing to them.  

Overtime on 106.7 The Fan
Britt Ghiroli, Juan Soto's AAV, Nell's Quick Clicks

Overtime on 106.7 The Fan

Play Episode Listen Later Jul 21, 2022 41:43


Overtime with Lynnell Willingham 1:00 Britt Ghiroli of the Athletic joins to talk the Nats and Juan Soto. 14:00 More on Juan Soto and what his AAV could and should be. 33:50 Nell's Quick Clicks.

Grant and Danny
Slowest day of the sports calendar, Would you pay Soto the $43 million AAV?

Grant and Danny

Play Episode Listen Later Jul 20, 2022 38:04


7.20.22 Hour 1 1:00- We open up the show talking a little about the All Star game, and then we move on to talk about how this is the SLOWEST day in the sports calendar by a long shot.  18:00- Jon Heyman was on this morning with the Junkies, and he hinted at the fact that Juan Soto could be looking for a $43 million dollar AAV. Would you pay that hefty tag? 

Locked On Avalanche - Daily Podcast On The Colorado Avalanche
We're Back From Vacation! Let's Talk About All That Happened Last Week!

Locked On Avalanche - Daily Podcast On The Colorado Avalanche

Play Episode Listen Later Jul 18, 2022 40:20 Very Popular


After a very long and busy Colorado Avalanche season we needed a little break and decided to take that break during free agency week of all things. But we're back and we can still talk about the moves the Avs made. On the ice and in the front office. Chris MacFarland has been around for all of this Avalanche success, he just doesn't get the recognition Joe Sakic does. It had been rumored Sakic would either retire or take a higher up job with the franchise if the Avs won the Cup, and that is exactly what happened. Sakic is no President of Hockey Operations and MacFarland removes the 'Assistant' from his title and is now the Avalanche GM. Don't expect much to change when it comes to how the Avs do business. Sakic and MacFarland have been working in unison for years and that will likely continue. MacFarland was a busy man in his first days on the job. The biggest moves were in signing three key free agents. Josh Manson (4 years $4.5 AAV), Artturi Lehkonen (5 years, $4.5 AAV) and the biggest one in Val Nichushkin (8 years, $6.125 AAV). The Avs are clearly trying to keep as much of this team together as possible. But one name from last year is still out there waiting for his deal, Nazem Kadri. The Avalanche are very much in the mix for their 2C and will have to move a current player to keep him. Could we see MacFarland pull off a trade that keeps the fan favorite in Denver? We will see. Chris and Kyle have a lot to talk about! Tune in and subscribe! BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Canadiens - Daily Podcast on the Montreal Canadiens
Episode 659 - Montreal Canadiens trade Jeff Petry, Ryan Poehling to Pittsburgh for Mike Matheson, Rem Pitlick is back!

Locked On Canadiens - Daily Podcast on the Montreal Canadiens

Play Episode Listen Later Jul 18, 2022 30:45


After a long wait, the Montreal Canadiens have finally found a partner for a Jeff Petry trade, shipping the defenceman, and forward Ryan Poehling to the Pittsburgh Penguins for Mike Matheson and a draft pick. At first glance it feels like a loss for the Canadiens as their top right side defender is shipped out of town, leaving just David Savard in that role. However, as the hosts take a look at his microstats and development trend, did Kent Hughes pull off a sneaky good bit of work? At the very least, the Canadiens freed up more cap room, which allowed them to make more moves over the weekend as well. Namely, Montreal has re-signed Rem Pitlick to a two-year contract! After electing to not qualify the forward, thus avoiding arbitration, the Canadiens were able to bring him back on a very cheap $1.1million AAV contract for the next two years. Where does Pitlick slot into the lineup, and does his return slow the full-time NHL debuts of Jesse Ylönen and Rafaël Harvey-Pinard? The Habs weren't the only busy team though, as the Laval Rocket made a slew of moves to get themselves ready for next season. Scott takes a look at the return of Gabriel Bourque to the Rocket, in addition to the new prospects joining the goaltending posse. Who is Philippe Desrosiers and Joe Vrbetic and where do they fit in the Montreal goaltending pipeline? Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Nats Chat
Game 93: Soto's D.C. Future in Doubt After Reportedly Turning Down Mega Offer

Nats Chat

Play Episode Listen Later Jul 17, 2022 39:07 Very Popular


The Nats lost 6-3 to the Braves, but that was not the main news Saturday from South Capitol Street. Mark & Al respond to the pregame news from The Athletic's Ken Rosenthal that Juan Soto turned down a 15 year/ $440 Million contract extension offer and therefore the Nationals would be open to trading Soto. Will Soto still be in Washington after this year's trade deadline? (14:02) A deep dive into the contract particulars and each side's perspective as ownership's future is uncertain. Hear why the average annual value (AAV) is "too low". Was there deferred money involved? (30:10) A quick recap of the 9th consecutive loss for the Nats. Josh Bell did collect three hits on Saturday as his average is now up to .311. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Devils - Daily Podcast On The New Jersey Devils
The New Jersey Signed Ondrej Palat to a 5-Year Deal...Is He Our New Leader?; Simon Nemec Signed His Entry Level Contract

Locked On Devils - Daily Podcast On The New Jersey Devils

Play Episode Listen Later Jul 15, 2022 26:37


The New Jersey Devils went with their plan B option and signed Ondrej Palat to a 5-year $30 million ($6 million AAV) contract. While he might not be the most flashy player in the NHL, he can definitely still be a huge help for the Devils both on the rink and in the locker room. In addition to his signing, Simon Nemec signed his entry level contract. So, the future is now for New Jersey. Subscribe to Locked On Devils! Follow me on Twitter: @treymatt4 Follow the show on Twitter: @LockedOnDevils Listen to Locked On Devils: https://linktr.ee/LockedOnDevils Support Us By Supporting Our Sponsors! Built Bar: Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline: BetOnline.net has you covered this season with more props, odds, and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Oilers - Daily Podcast On The Edmonton Oilers
The Edmonton Oilers get their Goaltender!

Locked On Oilers - Daily Podcast On The Edmonton Oilers

Play Episode Listen Later Jul 13, 2022 35:20


On today's episode of Locked on Oilers, it's FREE AGENT FRENZY DAY! The Edmonton Oilers make a splash in the crease and sign Jack Campbell out of Toronto! What does Campbell bring to the club? Can the Oilers win with Campbell in the net? And what are the expectations from Campbell? We will go over that; plus, the Edmonton Oilers re-signed Evander Kane late last night to a team-friendly deal. Why did Kane take a smaller AAV and can he re-capture the magic he had with Connor McDavid last season? Finally, the Oilers also re-signed Brett Kulak after he declared he was testing Free Agency. How substantial is that for the Oilers and what happens next? All that and more on today's episode of Locked on Oilers!  Subscribe to our YouTube channel: Locked on Oilers Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

A2D Radio
Philadelphia Flyers SIGNING JOHNNY GAUDREAU!? | Philadelphia Flyers + NHL Free Agency Targets

A2D Radio

Play Episode Listen Later Jul 13, 2022 149:25


NHL Free Agency is upon us and the question on everyone's mind is will Johnny Gaudreau resign with the Calgary Flames or will he become a Philadelphia Flyer? Tonight, we look into what the future holds for the All Star Left Wing.What happens if the Flyers are unable to secure Gaudreau? Would they possibly look at another Flame in Matthew Tkachuk, who Calgary is also looking to ink to a long-term contract? Or will the Flyers turn their attention towards their Keystone State rivals and steal Evgeni Malkin from the Pittsburgh Penguins? It's become clear, if the Pens are going to bring Malkin back, it will be on their terms, not his. The club prioritized re-signing Kris Letang and got that done by signing the defenseman to a six-year, $36.6 million contract ($6.1 million AAV). Also on the show, we'll predict if Patrice Bergeron will take one last ride with the Boston Bruins or call it a career. Will David Krejci return to both the NHL and Bruins? Also, with the Toronto Maple Leafs, Edmonton Oilers, Washington Capitals and Buffalo Sabres all in the market for a No. 1 goalie, where will UFA netminders Darcy Kuemper (fresh off a Stanley Cup win), Jack Campbell, Braden Holtby, Jaroslav Halak, Thomas Greiss and Martin Jones land? Matt Murray, was on the table but late Monday evening, the Toronto Maple Leafs picked him up along with a 2023 3rd round draft pick & a 7th round pick in 2024 for future considerations. The New York Rangers now need a backup to Vezina-winning goalie Igor Shesterkin after trading Alexandar Georgiev to the Colorado Avalanche. But a more pressing issue will be signing a second-line center with both Ryan Strome and Andrew Copp becoming unrestricted free agents. The Stanley Cup champs have a busy offseason in store with many FAs, and Nazem Kadri tops the list. Ondrej Palat could be one of the steals of this free-agent class if the Tampa Bay Lightning can't sign the forward. And John Klingberg could be on the move, as well! Will old friend Claude Giroux move back home and sign with the Ottawa Senators now that they have acquired Alex DeBrincat? Answers to these questions and more plus a review of the 2022 NHL Draft, and don't forget the Shootout, where the boys hit on rapid-fire topics to close us out!

The Ryan Kelley Morning After
07-13-22 Segment 3 Robert Thomas, Ballsack Sports, and EMOTD

The Ryan Kelley Morning After

Play Episode Listen Later Jul 13, 2022 43:56 Transcription Available


Gimp masks. Robert Thomas getting a nice little raise. Is #18 worth that AAV? ESPN had to retract a quote they took from a Ja Morant interview, via Ballsack Sports. Iggy has to pee. Iggy will be playing a match vs. Steve from BPV. $200 on the line. Iggy does some ASMR on-air. EMOTD

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins
Can the Penguins salvage this relationship with Evgeni Malkin? Josh Yohe returns to the show...

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins

Play Episode Listen Later Jul 12, 2022 56:37 Very Popular


As promised, Josh Yohe of The Athletic joins the show to touch on EVERYTHING regarding the Pittsburgh Penguins. The two first chat about Evgeni Malkin (3:00) and if the team and his side can reconvene for a deal, plus how the Malkin camp is truly feeling right now. Josh also touches on how Sidney Crosby is doing his part to try and get Malkin to stay (and he never goes into these negotiations), plus if a four-year term was really offered, and who is to blame in this situation. He goes into the chances that Malkin potentially stays before Hunter & him go into potential replacements. What would a Vince Trocheck contract look like? Is there a way to trade for JT Miller? The two also discuss if the Penguins are close to offloading a defenseman and argue for which one it should be before getting into the Rickard Rakell deal. How fast did that one come together? Is there concern about the term and AAV? What happens if he doesn't play with Crosby? All that, plus a lot of other info is in this episode of the Locked On Penguins podcast. Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Avalanche - Daily Podcast On The Colorado Avalanche
Georgiev Signs a Deal. We Come Up With Deals for Mack, Nuke and Lehkonen. Grades for Byram, Cogliano

Locked On Avalanche - Daily Podcast On The Colorado Avalanche

Play Episode Listen Later Jul 11, 2022 44:53 Very Popular


The newest member of the Colorado Avalanche has his contract. After being acquired for three draft picks. RFA Alexander Georgiev sign a three year contract for $3.4 AAV. Which means the Avs will have a very modest $5.4 million dollars total for both goalies. If it works, it's genius. If it fails, many questions will be asked. We also put our mythical GM caps on and throw out the offers we would make for three key Avs players. What would we offer UFA Val Nichushkin, RFA Arturri Lehkonen and what is the extension we would throw to superstar Nathan MacKinnon? Finally, we have two grades to pass out for last season. One for Bowen Byram and the other for Andrew Cogliano. Tune in and subscribe! BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins
Is there momentum building towards a Kris Letang deal?

Locked On Penguins - Daily Podcast On The Pittsburgh Penguins

Play Episode Listen Later Jul 2, 2022 27:34 Very Popular


It's finally July! The offseason continues to rage on and the news with the Pittsburgh Penguins never sleeps. Hunter starts the show by touching on the latest regarding Kris Letang as Elliotte Friedman gave an update on 32 Thoughts. Are the two sides getting closer? What's the gap now? Hunter shares some optimism towards a new deal as he's feeling more confident about a deal getting done with Letang than he does with Malkin. He also touches on the David Pagnotta update and whether there's a chance that Letang's AAV could be below 8. Following that, Hunter gives his thoughts on the rumors that the Penguins are discussing a new deal with Casey DeSmith. There are some conflicting reports, but which way should the Penguins go? Is it right to look for a new backup? Has DeSmith done enough to earn that job for a third straight season? Finally, Hunter ends the show with a little more draft talk as he gives a couple more names that could be available to them, plus takes a listener's question about a potential free agent fit. Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Locked On Lightning - Daily Podcast On The Tampa Bay Lightning
Paul inks 7-yr deal. Who else is staying and who is leaving?

Locked On Lightning - Daily Podcast On The Tampa Bay Lightning

Play Episode Listen Later Jul 2, 2022 43:39


Nick Paul and the Bolts came to an agreement early Friday on a 7-yr contract worth 3.15 AAV. Adam discusses the unexpected early signing and when we might see decisions on the fates of other plays whose futures hang in limbo. Adam also wraps up the show by addressing some of the comments we received from YouTube.  Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. https://www.youtube.com/channel/UClEnMX-CSZKA6ZHiXDU7Y3Q Learn more about your ad choices. Visit podcastchoices.com/adchoices

Biotech 2050 Podcast
109. Gene therapy CDMO, Tim Miller, CEO, Erandi De Silva, SVP of Prod. Dev., Forge Biologics

Biotech 2050 Podcast

Play Episode Listen Later Jun 29, 2022 21:50


Timothy J. Miller, Ph.D. CEO, President and Co-Founder Timothy Miller is CEO, President and Co-Founder of Forge Biologics, Inc., a VC-backed gene therapy development engine focused on accelerating access to potentially life-saving AAV gene therapies. Prior to founding Forge, Dr. Miller co-founded Abeona Therapeutics, a rare disease gene and cell therapy company. He served as Abeona's CEO and President from 2012-early 2018, taking the company public in 2015. He is a proven biotech leader with experience in driving gene therapy pipeline development, regulatory strategy, investor relations, M&A activities, licensing, GMP manufacturing, clinical development, and leading stakeholder/shareholder engagement. Dr. Miller has over 20+ years of business development, scientific research, product development and clinical operations expertise, with a focus on transitioning novel gene and cell therapies through pre-clinical and Phase 3 human clinical trials. He is an avid patient-centric drug developer and entrepreneur. Dr. Miller earned degrees in Pharmacology (Ph.D.) and Biology/Molecular Science (M.S. and B.S.) from John Carroll University. Erandi De Silva, Ph.D. Co-Founder & Senior Vice President of Product Development Erandi De Silva is Co-Founder and Senior Vice President of Product Development at Forge Biologics. She is an experienced scientist and entrepreneur, with 10+ years of experience in discovery research, therapeutic development, and partnering across oncology, infectious disease, and gene therapy. Prior to founding Forge, Dr. De Silva held leadership roles in both academic and industry settings, including at Myonexus Therapeutics. She earned a Ph.D. in Molecular Biology from Princeton University, where she was awarded the Procter Fellowship in recognition of exceptional research, and her B.S., with honors, from Stanford University. Dr. De Silva was also a Postdoctoral Research Scientist at Genentech.

Cell & Gene: The Podcast
Moving On from AAV with Poseida Therapeutics' CEO, Mark Gergen

Cell & Gene: The Podcast

Play Episode Listen Later Jun 23, 2022 27:36


Poseida Therapeutics is a broad platform technology company led by CEO, Mark Gergen. During this episode, Gergen explains how and why the company is moving away from AAV delivery in favor of nanoparticle delivery. He shares some of the biggest hurdles the CGT sector faces when it comes to the development of off-the-shelf therapies as well as the manufacturing challenges Poseida has had to overcome and how they did it.

Locked On Wild - Daily Podcast On The Minnesota Wild
Should the Wild Retain Their Free Agents?

Locked On Wild - Daily Podcast On The Minnesota Wild

Play Episode Listen Later Jun 21, 2022 35:32


On today's episode of Locked on Wild, we revisit free agency with the news that the Salary Cap for 2022-23 will be $82.5 million. We look at the Wild's current cap obligations, and how much money they will have to spend once free agency begins. We look at the Wild's current Free Agents, starting with Marc-Andre Fleury. Should the Wild look to re-sign him? What are the other options on the market? Can the Wild offer him a multi year deal to bring down his AAV? We also discuss whether or not the Wild should bring back Nick Bjugstad, Nic Deslauriers or Jordie Benn. Should the Wild look to younger options instead? What about Connor Dewar? We rank the Wild's free agent priorities to finish out. Subscribe to our YouTube Channel: Locked On Wild Follow/Subscribe Anywhere: linktr.ee/LockedOnWild Follow Locked On NHL: linktr.ee/lockedonNHL Support Us By Supporting Our Sponsors! | Offers from our sponsors: lockedonpodcasts.com/offers Built Bar - Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline - BetOnline..net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto - Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Athletic Greens - Athletic Greens is going to give you a FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase. All you have to do is visit athleticgreens.com/NHLNETWORK. Learn more about your ad choices. Visit podcastchoices.com/adchoices

OIS Podcast
Inside the Ocular Biofactory, with Thomas Chalberg, PhD

OIS Podcast

Play Episode Listen Later Jun 15, 2022 39:07


Scientist, entrepreneur, and executive Thomas Chalberg, PhD, has developed or funded companies that have advanced complex gene therapy technology, a novel anesthesia delivery system, and a lens that helps slow myopia progression in kids. And that's just the start.A leader in gene therapy development who is recognized by the World Economic Forum as a Technology Pioneer, Dr. Chalberg cofounded Avalanche Biotechnologies, which is now Adverum Biotechnologies. There, he built the Avalanche Ocular BioFactory, an adeno-associated virus (AAV)–based, proprietary, next-generation platform for the discovery and development of gene therapy vectors for ophthalmology.While much of his career has centered on gene therapy, one of his more recent ventures, SightGlass Vision, falls on the opposite end of the spectrum. The company has developed a novel spectacle lens design that helps slow myopia progression. Its foundation stems from research by the University of Washington, which found that high retinal contrast signaling leads to high myopia and that modifying that signaling could slow myopia progression.Dr. Chalberg also is founder and managing director of Polymerase Capital; founder and managing director of iRenix Medical, which developed a novel anesthesia delivery system used in conjunction with intravitreal injections; director of Chameleon Biosciences, a gene therapy–focused startup; and founder and CEO of Genascence Corp., a gene therapy startup developing products for musculoskeletal disease.In between all this activity, Dr. Chalberg caught up with Firas Rahhal, MD, to talk about—what else?—gene therapy, along with retinal disease and his history in the anti-VEGF market.Listen to the podcast today to hear: About Dr. Chalberg's work at Genentech during Lucentis' launch and early commercialization. The philosophy behind iRenix Medical's anesthesia delivery system, which administers a cooling anesthesia via an automated injector. His thoughts on the safety and effectiveness of gene therapy and gene editing for ophthalmic indications and how he sees it evolving over the next several years. Will it replace monoclonal antibodies, serve as an adjunct, or neither? How Dr. Chalberg got started in ophthalmology and retinal disease specifically.Click “play” to listen.

The Evidence Based Rheumatology Podcast
E85: Challenging Wisely

The Evidence Based Rheumatology Podcast

Play Episode Listen Later May 23, 2022 7:58


Quick episode today. I wanted to share an editorial that was recently published in Rheumatology, where I and co-authors (Shannon Tai and Natalie Anumolu) discuss lessons from recent trials in AAV and SLE.    Link to editorial: https://pubmed.ncbi.nlm.nih.gov/35438142/