Podcasts about AAV

Sunday May 18, 2025. Week 21   Show notes on the site: https://curesyngap1.org/podcasts/syngap10/    CAMP4 Press Release https://investors.camp4tx.com/news-releases/news-release-details/camp4-presents-translational-data-syngap1-related-disorders Dr. Yuri at WODC: https://www.youtube.com/watch?v=oNwgo7TmrVo Presentation at ASGCT: https://investors.camp4tx.com/news-events/presentations GETA Talk: https://www.facebook.com/Syngapresearch/posts/pfbid08Aztex32vdwNZduVkPQeG353W49Dhq8iKJeZEkajKUmkeUiDdCwzyqa9ndEVpdCUl    To get these Therapies to kids the NHS data is key, ProMMis CHOP - Email them ENDD@chop.edu Stanford (Singed!) - https://curesyngap1.org/blog/srf-announces-stanford-launches-california-synaptopathy-clinic/ CHCO - https://curesyngap1.org/blog/visiting-syngap1-natural-history-study-childrens-hospital-colorado-chco/ Citizen Health https://cureSYNGAP1.org/Citizen is at 267, why not 300?   Hopkins article featuring SRF - Competition is good for the patient FB https://www.facebook.com/cureSYNGAP1/posts/pfbid07MP7St3zdxLKYXTJULKa5S35YvgL6AJndenHicedxU3rtQF6iY1wwwNUoDuUD9cpl LI https://www.linkedin.com/posts/curesyngap1_nih-cuts-stalling-progress-on-rare-genetic-activity-7328449817074946048-AAsB   ASGCT Mouse poster for Q504X from the JAX, Dr. Matt Simon Conf Video https://www.youtube.com/watch?v=loYXkkTSUIY  Presentation on AAV for SYNGAP1 at Allen by Dr. Megan Quinlan   What about this guy? Gift link: https://www.nytimes.com/2025/05/15/health/gene-editing-personalized-rare-disorders.html?unlocked_article_code=1.H08.E-oX.t5bo6kxJGUOU&smid=url-share  PBS: https://www.youtube.com/watch?v=dOeiPoa3gvM Eric Topol: https://erictopol.substack.com/p/the-first-human-to-undergo-in-vivo   More incredible news https://news.unl.edu/article/husker-team-wins-second-round-prize-in-nih-gene-editing-challenge   REPURPOSING Mike's post in private SRF Group: https://www.facebook.com/groups/syngap #Amlexanox with Fortuity Pharma. https://fortuitypharma.com/    Butyrate Update https://aesnet.org/abstractslisting/phenylbutyrate-for-syngap1-related-developmental-and-epileptic-encephalopathy Trial ending at year end, working with SLC6A1 and Rachel Heilmann to continue coverage, then we can scale, once we have a paper. SunButyrate https://a.co/d/7kiHXS8    PUBMED  328 total with 20 YTD https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&sort=date&sort_order=asc&timeline=expanded Sleep https://www.sciencedirect.com/science/article/abs/pii/S1389945724005793?via%3Dihub   SRF Fundraisers MDBR with AJH and HM https://curesyngap1.org/calendar/million-dollar-bike-ride-2025/   Well done to Tavilla and Jones!  We are over $221k Tavilla clears $160k for Sprint. https://donate.curesyngap1.org/campaign/sprint4syngap2025/c660255   Porter Jones and his friends William, Patrick, and Judson raised over $10k in doughnuts, this netted over $8k because people donated.  Amazing and thank you to Krispy Kreme.  https://donate.curesyngap1.org/event/sweets-for-syngap1/e678677   SRF PROFILES Vicky post in Mexico https://www.linkedin.com/posts/victoria-arteaga-26913433_diagnostico-epilepsia-syngap1-activity-7329725268003069953-R41P Vicky's Siblings Violeta and Lourdes, sisters to Amelia https://curesyngap1.org/syngap-siblings/ Harper Albrecht Wednesday Warrior #215 parents Ashley and Justin https://cureSYNGAP1.org/Warrior   PREREGISTER FOR THE CURE SYNGAP1 CONFERENCE https://curesyngap1.org/calendar/cure-syngap1-conference-2025-hosted-by-srf/

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.The White House has announced a new drug pricing policy that includes the revival of the most favored nations rule and extends to the private markets, leveraging the patent system, drug importation, and more. Meanwhile, Lilly's Zepbound has been found to have a superior benefit-risk ratio compared to Novo's Wegovy, BMS and Sanofi settle a Plavix lawsuit with Hawaii for $700 million, and biopharma companies are focusing on developing a cure for HIV as federal funding for related research is being cut. Sino Biological offers comprehensive solutions for autoimmune diseases, and Roche promises a $300 million investment in China production after a multibillion-dollar investment in the US. On the other hand, Lexeo and IGM have both announced significant layoffs. Novartis CEO has expressed concerns about Trump's pricing controls.Funding for HIV-related research and infrastructure is being cut by the Trump administration, leading biopharma companies like Gilead and Immunocore to focus on finding a cure for HIV. In the field of neurology, there is a need for more precise diagnostic tools to effectively treat neurodegenerative conditions. The new HHS vaccine requirement has been criticized by leading vaccine physician Paul Offit as potentially being anti-vaccine activism disguised as policy. Companies like Novartis, Bayer, and AstraZeneca are exploring new indications and innovations in radiopharmaceuticals, hoping to capitalize on a market that could reach $16 billion by 2033. The FDA has faced delays in reviewing certain drugs, while biotech stocks have fallen after the appointment of Vinay Prasad to succeed Marks at CBER. Vertex has decided to abandon AAV in the gene therapy space.Upcoming events include a webinar on surviving and thriving in the biotech downturn. Job opportunities in the biopharma industry include positions at Takeda, Daiichi Sankyo, and AbbVie. Heather McKenzie, senior editor at BioSpace, is open to suggestions for future coverage topics in neuroscience, oncology, cell & gene therapy, metabolic, or other areas.

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive's Stephen Gunnion about the company's latest milestone—a successful £0.5 million fundraising to support a gene therapy trial in ageing dogs using SIRT6. Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” The trial aims to demonstrate proof of concept in dogs, replicating promising results previously seen in mice. “It worked like magic in mice. We reasonably think that it will work likewise in dogs,” Leire stated. Unlike mice, however, dogs share environmental conditions with humans, making them a more relevant model for translation into human therapies. Leire also highlighted the commercial potential of targeting animal health, as it offers a shorter regulatory pathway compared to human applications. He confirmed that the trial has reached a key milestone: the randomisation of 24 senior dogs, aged over ten years, into four arms, including one control group and three treatment groups using different SIRT6 delivery methods. He also addressed ethical considerations, stating that the therapy does not involve genetic modification, and described the use of non-integrating gene therapy approaches, including naked DNA and AAV vectors. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #GenflowBiosciences #GeneTherapy #SIRT6 #DogAgingTrial #LongevityResearch #BiotechFunding #AnimalHealth #AntiAging #Biotechnology #ClinicalTrials #LifeSciences #InvestingInBiotech #SeniorDogs

On hour two of Flames Talk, Pat Steinberg is joined by Eric Francis for a full hour to break down Matt Coronato's seven-year, $6.5 million AAV extension with the Calgary Flames. Pat and Eric dig into why the Flames prioritized locking up Coronato long-term, how the deal got done with a number starting with a six, and why it's a win for both the organization and the player. They also discuss what message it sends to see an American-born player commit to Calgary, and how high Coronato's ceiling could be as he enters the prime years of his career.(35:03) Later, Pat and Eric shift gears to Dustin Wolf and whether the Flames should aggressively pursue a long-term extension for the goaltender when he becomes eligible on July 1. The guys debate how Calgary could convince Wolf to sign, how much risk comes with term for a young netminder, and what kind of offer might get it done sooner rather than later.The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Media Inc. or any affiliate. https://www.sportsnet.ca/960/flames-talk/

On this week's episode, we name and debate our Mount Rushmore for each position in the history of baseball. From there, we discuss the highest paid player (by AAV) at each spot on the diamond, the elimination of the buffer zone by umpires that has hitters and pitchers guessing the strike zone like never before, roster moves in Detroit, Texas, and Cincinnati, and which baseball players would be our top choices to enlist to be a part of our 100 player roster in a battle to the death against a gorilla.

On hour one of Flames Talk, Pat Steinberg is joined by Daily Faceoff's Frank Seravalli to dig into the early offseason priorities for the Calgary Flames. The guys talk about what Dustin Wolf's next contract could look like and whether Matt Coronato is a candidate for a long-term deal. They also hit on Rasmus Andersson's uncertain future, Rick Tocchet's Vancouver tenure coming to an end, Mike Sullivan's exit in Pittsburgh, and coaching possibilities across the NHL. Plus, Frank shares his thoughts on the Stars' dominance, the Oilers' outlook heading into Game 5, and the tight battle between Winnipeg and St. Louis.(26:55) Pat and Aaron Vickers take a hard look at Morgan Frost — maybe the toughest RFA for Calgary to figure out this summer. Frost had 12 points in 32 games after being acquired from the Flyers, and now the team has to decide what he is, what he could still become, and what kind of deal makes sense. With Frost one year from UFA eligibility and turning 26 soon, the guys debate whether a four-year, $4 million AAV contract is a realistic target. The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Media Inc. or any affiliate. https://www.sportsnet.ca/960/flames-talk/

In today's pod we break down the Cowboys future and in particular why it scares me. They are in a tough position to try to go from being a good team when healthy - to a great team. And it makes matters a lot more difficult when they are paying a quarterback an AAV of $60M per year along with a new head coach. I hope you enjoy! TWITTER: https://mobile.twitter.com/FBallAnalysisYT   DISCORD: https://discord.gg/XAjBEcGVbH   TIKTOK: https://vm.tiktok.com/ZMe5NbVa7/   Welcome to the Football Analysis Podcast! Subscribe for all NFL related content! Please drop 5 star rating if you enjoyed the pod as all support is very much appreciated! Thanks for listening!     #nfl #nflfootball #football #nfldraft #dallascowboys #cowboys    Support Us By Supporting Our Sponsors!   UNDERDOG Fantasy:  Up To $1,000 Bonus Cash When You Make Your First Deposit:  https://play.underdogfantasy.com/p-football-analysis     Gametime: Download the Gametime app (https://gametime.co/) and redeem code ANALYSIS for $20 off your first purchase (terms apply)

We love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, Host Erin Harris dives into the world of retinal gene therapy with Kenji Fujita, M.D., Chief Medical Officer of Atsena Therapeutics. Atsena develops treatments for inherited retinal diseases, including X-linked retinoschisis (XLRS), a rare genetic condition that currently has no FDA-approved therapy. They talk through the impact of XLRS on patients, the challenges of gene delivery to the retina, and how Atsena's AAV vector technology is designed to overcome these hurdles. They also discuss the significance of the Fast Track designation recently granted to Atsena's XLRS program, the role of patient advocacy in rare disease research, and the key milestones to watch for in the months ahead.Subscribe to the podcast!Apple | Spotify | YouTube

We are building up to the deadline! We discuss Chicago trading Petr Mrazek and Craig Smith in exchange for Joe Veleno to the Red Wings, Charlie Coyle is off to Colorado for Casey Mittelstadt who is off to Boston, and Wyatt Johnston signs an extension with Dallas for 5 years at $8.4 AAV!SHOUTOUT TO OUR SPONSORS!!

Audio roundup of selected biopharma industry content from Scrip over the business week ended 28 February 2025. In this episode: which big companies face the least LOE hit?; IPOs rise in 2024; Pfizer cuts last AAV gene therapy program; balance and focus suggested for globalizing Chinese firms; and Scrip Asks on therapeutic area advances. https://insights.citeline.com/scrip/podcasts/scrips-five-must-know-things/quick-listen-scrips-five-must-know-things-4RXPQH4B5NBJ3AM7SFMPROUJ2U/ Playlist: soundcloud.com/citelinesounds/sets/scrips-five-must-know-things

In today's over/under Casey Warner sets the lines on Lightning end of season win total, Nikita Kucherov's point total, how far is a "long drive", Matthew Stafford's new deal AAV and Lakers end of season win total.

Fantasy Baseball Live – February 16 2025 @ 3 pm ETSegment 1 – News and Notes1.Alex Bregman finally signed with Boston for three years and $120 million. While it wasn't a lengthy deal, the AAV of $40 is tremendous. Of course, he can opt-out after each year.a.Let's examine the Boston Red Sox lineup to see what shakes out given that there is a strong possibility he plays second.2.Many thought the Padres were sellers, but they signed Nick Pivetta to a four-year, $55 million contract.a.He had a solid season in 2024 – 172 Ks in 142 IP with a 4.14 ERA. The data says there is more in the tank, and Petco will help with his flyball tendencies—what are your thoughts?Segment 2 – Outfield Preview1.How are you approaching this position for your upcoming drafts?2.We will break down the top 30 to 45 in detail. Then, go through 30 or so in less detail. We will end by jumping around the remaining ranked players.3.Which player not in the Top 10 has a chance to emerge there next season?4.Which Top 10 player will not be there next season?5.Give me a couple of sleepers6.Give me one, maybe two guys you are just going to avoid drafting?

Fantasy Baseball Live – February 16 2025 @ 3 pm ETSegment 1 – News and Notes1.Alex Bregman finally signed with Boston for three years and $120 million. While it wasn't a lengthy deal, the AAV of $40 is tremendous. Of course, he can opt-out after each year.a.Let's examine the Boston Red Sox lineup to see what shakes out given that there is a strong possibility he plays second.2.Many thought the Padres were sellers, but they signed Nick Pivetta to a four-year, $55 million contract.a.He had a solid season in 2024 – 172 Ks in 142 IP with a 4.14 ERA. The data says there is more in the tank, and Petco will help with his flyball tendencies—what are your thoughts?Segment 2 – Outfield Preview1.How are you approaching this position for your upcoming drafts?2.We will break down the top 30 to 45 in detail. Then, go through 30 or so in less detail. We will end by jumping around the remaining ranked players.3.Which player not in the Top 10 has a chance to emerge there next season?4.Which Top 10 player will not be there next season?5.Give me a couple of sleepers6.Give me one, maybe two guys you are just going to avoid drafting?

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/managing-patients-with-aav-in-the-rheumatology-clinic/32353/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/elevating-care-for-patients-with-severe-renal-disease-in-aav/32352/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/dont-miss-it-rapid-accurate-aav-diagnosis/32348/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/implementing-the-soc-induction-therapies-in-aav/32349/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/optimizing-aav-outcomes-maintenance-therapies/32350/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

CME credits: 0.75 Valid until: 14-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/tailoring-treatment-for-optimal-outcomes-in-patients-with-aav/32351/ Blood vessel inflammation that occurs with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis – or AAV – often results in damage that can lead to multi-organ involvement. This makes early diagnosis of this rare, autoimmune disease important for developing an effective treatment plan and personalized treatment selection a key success factor in the optimization of patient care.

SEGMENT - After years of passiveness from Red Sox ownership, the Sox have agreed to a 3-year deal with 3B Alex Bregman carrying an AAV of $40 million. But Jones is skeptical to say that the Sox are fully back

- Alex Bregman and the Boston Red Sox agree on a three-year, $120 million contract- $40 AAV a season- Alex Bregman's tenure in a Astros uniform- Clubhouse leader- Fenway Park favors Breggy- What's next for Houston?- Astros have their guy at third base- Does Bregman not being in Houston hurt their chances at winning the division- Much, much, more!YouTube link: https://youtube.com/live/4gCdf54z3jsHave you subscribed to the Full Seam Ahead YouTube Channel yet? Make sure to hit that subscribe button and hit that notification bell to stay up to date on all the latest Astros news, rumors, interviews, live streams, and much more all year long!

Alex and Facci discuss Alex Len not signing with Indiana, and the Pacers bringing in Jahlil Okafor on a 10-day contract. Then, they answer Pt. 1 of the Mailbag Podcast. 1). Northeast Nightmare over on Blue Sky has 3 questions for us!  A). First, rank which opponent you'd like to see Indiana face in the first round out of Milwaukee, Detroit, Miami and Orlando. 1st by matchup, 2nd by storyline.  B). Do you think Myles Turner will credit the Pacers $10M towards his next contract since Indiana did him a service and paid him nearly $30M a year on the last renegotiation and extension?  C). Will the Pacers use Isaiah Jackson's disabled player exception to sign Alex Len? Is there any benefit towards that? (Mentioned James Johnson needing to be released, but this is why they traded Wiseman).  2). Aaron M — THE GOVERNOR of the Setting The Pace Fan Club  Do you think the best chance for the Pacers to win an NBA title is actually continuity, or is that just a word they throw around? This is considering the odds the Pacers win the #1 pick are zero like they appear to be.  3). Chuck and Jamie — THE OG FANS OF THE WEEK! At the halfway point: What has been your biggest surprise this season? Who has made the most improvements? Who/what has been the most disappointing? One thing you hope to see in the second half of the season? 4). Roosters — the President of the Setting The Pace Fan Club  In your estimations what are the chances Herb goes into the tax this offseason to sign Myles to a long term deal? Also, what would you be willing to sign him to if it were up to you? Personally I'd try to get him for 5/100 and offer him a NTC. Knowing may have to go higher AAV. Learn more about your ad choices. Visit podcastchoices.com/adchoices

James Anderson and seasoned NFBC Auction player Marc Winokur go through some recent high-stakes auctions and which players are more in-demand by auction players than by snake draft players! 00:00 Intro 01:20 Early Auctioning 13:10 Closers in Auctions 20:30 Buying Skubal 28:00 Old, boring SP2s 32:50 What A Cheap Offense Looks Like 38:00 Zero-Dollar Players 40:55 Stacking 46:00 Top Hitters Overpriced 50:00 AAV vs. ADP 54:20 Outfielders 01:02:30 Catchers 01:05:10 First Base 01:06:00 Second Base 01:13:30 Shortstop 01:17:35 Pitcher Learn more about your ad choices. Visit podcastchoices.com/adchoices

James Anderson and seasoned NFBC Auction player Marc Winokur go through some recent high-stakes auctions and which players are more in-demand by auction players than by snake draft players! 00:00 Intro 01:20 Early Auctioning 13:10 Closers in Auctions 20:30 Buying Skubal 28:00 Old, boring SP2s 32:50 What A Cheap Offense Looks Like 38:00 Zero-Dollar Players 40:55 Stacking 46:00 Top Hitters Overpriced 50:00 AAV vs. ADP 54:20 Outfielders 01:02:30 Catchers 01:05:10 First Base 01:06:00 Second Base 01:13:30 Shortstop 01:17:35 Pitcher Learn more about your ad choices. Visit podcastchoices.com/adchoices

Summary:  This week on The Genetics Podcast, Patrick is joined by Eric Adler, Chief Medical Officer and Head of Research at Lexeo Therapeutics and Professor of Medicine at University of California San Diego. Eric shares his experience with genetic cardiomyopathy and his work on gene therapy for Danon disease, drawing from both clinical and research perspectives. Additionally, he explores the evolution of the field and the broader challenges faced by cardiovascular patients. Show Notes:  0:00 Intro to The Genetics Podcast 01:00 Welcome to Eric and his efforts in cardiomyopathy at the bench and bedside 03:32 How modeling genetic diseases using pluripotent stem cells lead Eric to studying Danon disease  04:50 Pivoting from basic to translational research using adeno-associated viruses (AAV)-based gene therapy 07:58 Uncovering genetic cardiomyopathies that were misdiagnosed as idiopathic cardiomyopathy 09:55 Treatment, screening, and penetrance of Danon disease 12:30 Recent successes and remaining challenges in cardiovascular disease 19:47 Battling distrust in the medical profession 21:55 Preventative therapy using APOE2 for patients at risk of early Alzheimer's   25:15 Motivations behind and advantages of Eric's patient-centered approach to therapeutics 27:24 Balancing regulatory requirements for protocols versus patient needs 29:49 The importance of committed clinical partners for successful trial execution 36:08 Eric's passion for cooking and how he won a cooking competition 39:02 Closing remarks and Lexeo Therapeutics' aims for 2025 Find out more Lexeo Therapeutics (https://www.lexeotx.com/) Please consider rating and reviewing us on your chosen podcast listening platform!  https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link

In a record setting performance, Alex Nedeljkovic scores a goal and adds an assist, the first time an NHL goalie has managed that feat. Meanwhile, did Connor McDavid escape discipline for a sneaky elbow?  Mike continues to be flummoxed by the unwillingness of Leafs fans to enjoy this season.     Listen Here:  Apple Podcasts   Direct MP3   iHeart Radio Title Player Don Marcotte  News Ndeljkovic scores - 16th goalie to score, 11th to shoot it https://www.nhl.com/news/nhl-goalie-goals-all-time-313758920 Took a hit to make the play! Also had an assist - 1st time ever goal and assist Scored 2 in AHL and 1 in ECHL - 1st ever  McDavid chicken wing - no fine or suspension - what do you think?  https://youtu.be/NX8P28Fjats?si=b8ALcjbaZgyl7BIX Oilers sign Klingberg - $1.75 AAV - 32 yrs old - gets $1MM - $350k bonus plus salary - hasn't played since Nov 2023 Oilers beat Kings, Wild and Avalanche this week - were done 3-0 to Avs and came back.  Matthews continues to score despite Leafs struggles lately  Rumours that Marchand might be on the trade block - last year of 8 yr contract - $6MM - 36 yrs - if Bruins fall out of playoffs will they move him?  Guess the 5th  Columbus Blue Jackets - where did they come from?  Last 10 - 8-10-0  6W in a row Currently in 1st wildcard in East Fancies GF% 51% (11)  xGF% 48.71% (25) SH% 10.03% (3) SV% (25)  Since Dec 1 GF% 51.55% (12) xGF 45% (28) SH% 9.8 (8) SV% 91.12 (17)  Since Dec 22 - have scored a PPG per game Have been on a hot streak but nothing to indicate it's real -  Schedule has been pretty soft over this span  Connections -  Last Week - lubes, swing, flase, teardrops - anagrams of NHL team names This Week - Claude Julien, Alain Vigneault, Pat Burns, Benoit Groulx  Crazy Stat -  DOPeS - Tsyplakov 3 games hit to head https://www.nhl.com/news/new-york-islanders-maxim-tsyplakov-suspended-3-games

Today's episode takes us into crucial territory where science meets ethics in gene therapy development. Following our recent compelling conversation with Ben Hurlbut on germline genetic editing, we're diving deeper into the ethical dimensions of bringing new treatments to patients. We'll explore two critical challenges that development teams face: determining the initial dose for therapy and establishing acceptable parameters for off-target effects before clinical testing. While these decisions are grounded in scientific data, they carry profound ethical implications – especially considering that AAV-based therapies are currently "one and done" treatments, where redosing isn't yet possible. Thomas Wechsler, chair of the ASGCT Ethics Committee, will join us to help us navigate the technical and ethical dimensions of these crucial decisions. His unique perspective will help us understand how teams balance scientific rigor with ethical responsibility when introducing new therapies to the clinic. Music by: https://www.steven-obrien.net/--------------------------Bright New Morning - Steven O'Brien (Used for free under a Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/)Show your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

While we still wait for Teoscar Hernàndez to return to LA, a new update on Corbin Burnes' market could be great news for the Dodgers. According to Ken Rosenthal, the 2021 NL Cy Young award winner may be open to a short-term, high AAV deal this winter - something right up Andrew Friedman's alley. I discuss the latest news and look at the Dodgers starting pitching and where it stands heading into the new year. Plus other Dodgers news and rumors; and voicemails on another edition of the All Dodgers Podcast! Tube in all offseason long! Leave a voicemail or text the Friend of the Show hotline!

Eno and DVR are joined by The Athletic's Ken Rosenthal to discuss Wednesday's trade that sent Garrett Crochet to the Red Sox, the importance of a lower AAV in Max Fried's deal with the Yankees, and an active Winter Meetings.Plus, they are joined by Esteban Navarro Garaiz of Zelus, Marlins Director of Pitching Bill Hezel, and former big leaguer Jed Lowrie to discuss each of their paths into baseball.Rundown0:00 Intro Starts13:31 Esteban Navarro Garaiz of Joins the Show34:52 Bill Hezel Joins the Show52:11 Jed Lowrie Joins the Show1:07:30 Goodbye from Dallas!Follow Eno on Bluesky: @enosarris.bsky.socialFollow DVR on Bluesky: @dvr.bsky.sociale-mail: ratesandbarrels@gmail.comJoin our Discord: https://discord.gg/FyBa9f3wFeSubscribe to The Athletic: theathletic.com/ratesandbarrelsHosts: Derek VanRiper & Eno SarrisWith: Esteban Navarro Garaiz, Bill Hezel & Jed LowrieProducer: Brian Smith Hosted on Acast. See acast.com/privacy for more information.

Eno and DVR are joined by The Athletic's Ken Rosenthal to discuss Wednesday's trade that sent Garrett Crochet to the Red Sox, the importance of a lower AAV in Max Fried's deal with the Yankees, and an active Winter Meetings.Plus, they are joined by Esteban Navarro Garaiz of Zelus, Marlins Director of Pitching Bill Hezel, and former big leaguer Jed Lowrie to discuss each of their paths into baseball. Rundown 0:00 Intro Starts 13:31 Esteban Navarro Garaiz of Joins the Show 34:52 Bill Hezel Joins the Show 52:11 Jed Lowrie Joins the Show 1:07:30 Goodbye from Dallas! Follow Eno on Bluesky: @enosarris.bsky.social Follow DVR on Bluesky: @dvr.bsky.social e-mail: ratesandbarrels@gmail.com Join our Discord: https://discord.gg/FyBa9f3wFe Subscribe to The Athletic: theathletic.com/ratesandbarrels Hosts: Derek VanRiper & Eno Sarris With: Esteban Navarro Garaiz, Bill Hezel & Jed Lowrie Producer: Brian Smith Learn more about your ad choices. Visit megaphone.fm/adchoices

Rundown [Intro] Sox Machine will be heading on the road to Dallas, Texas covering the 2024 Winter Meetings. The crew shares their favorite memories of past Winter Meetings and what to expect concerning coverage. [13:09] The Chicago White Sox still haven't officially announced their 2025 coaching staff, which creates confusion as to why and raises the open question of how new manager Will Venable isn't bringing more new faces to the clubhouse.  [27:01] Garrett Crochet will garner attention in Dallas, and James Fegan is hearing about the possibility of another three-team trade format [36:51] Frankie Montas and Matthew Boyd signed new deals with an AAV greater than $14 million despite recent injuries and poor performance. Is it time to reconsider how we calculate WAR/$ for pitchers as the free agency market continues to inflate? [46:03] There will be another vote for Hall-of-Fame as Dick Allen gets another crack. Will he finally make it, and why John Donaldson's contributions shouldn't be ignored. [1:00:00] Making fun of Rob Manfred's new rule proposal, the Rule 5 Draft for White Sox, and MLB Draft Lottery results Learn more about your ad choices. Visit podcastchoices.com/adchoices

Watch Off the Bench Presented by UDF with Chatterbox Sports Monday-Friday 10 a.m. - 12 p.m. LIVE on the Chatterbox Sports YouTube channel. SUBSCRIBE to the channel to ensure you never miss a thing. #rulethejungle #cincinnatibengals #nfl #nflfootball #nflnews #nflhighlights #mlbtheshow #mlb #mlbhotstove #bengals #bearcats #cincinnati #joeburrow #mlbbhighlights #atobttr #whodeynation #fccincinnati #mls #nflseason #cincinnatireds #reds #newenglandpatriots #baltimoreravens #kansascitychiefs ⏩ Watch More: ◼ Bengals MUST WIN in Kansas City Week 2 Preview | Chatterbox Bengals - https://www.youtube.com/live/aZtseW9lpH0?si=L5ZDcVwA2RZFg5zm ◼ Do Reds Fans Forgive Noelvi Marte? | CBox Man On The Street - https://youtu.be/Rwh4PudzJhs ◼ Asking Strangers if Cincinnati Reds David Bell Should be Fired | CBox Man on the Street - https://youtu.be/3Ye-HjJdmmQ ◼ NCAA EA COLLEGE FOOTBALL 25 GAMEPLAY REACTION! | CBox Reacts - https://youtu.be/hXQwjMcD244 Music from #InAudio: https://inaudio.org/ Riff Rock PODCAST LINKS: Apple: https://apple.co/3QsyY1C Spotify: https://spoti.fi/3KWJcWR Google Podcasts: https://bit.ly/3RwZ9We Stitcher: https://bit.ly/3BqqmEg iHeart Radio: https://bit.ly/3BtowTm Amazon: https://amzn.to/3Db8Rcw CHATTERBOX LINKS: Chatterbox Reds: https://linktr.ee/chatterboxreds Chatterbox Bearcats: https://chatterboxbearcats.podbean.com/ Chatterbox Bengals: https://www.youtube.com/playlist?list=PLjPJjEFaBD7WtWXJbcB_g2xYu7ST276R7 Chatterbox Clicker (Bengals Film Breakdown with Coach Kyle Caskey): https://www.youtube.com/playlist?list=PLjPJjEFaBD7V9GfyT1tl6M1dWQtQ9730Z The Chatter Podcast: https://queencitychatter.podbean.com/ Chatterbox Store: https://www.chatterboxsports.com/store TikTok: https://www.tiktok.com/@cboxsports Instagram: https://www.instagram.com/cboxsports/ Twitter: https://twitter.com/CBoxSports Facebook: https://www.facebook.com/cboxsports The Gangs Socials - Twitter: https://twitter.com/ThomBrennamanTV Twitter: https://twitter.com/ReidMausRadio Twitter: https://twitter.com/etrain513 Twitter: https://twitter.com/CBoxCasey Twitter: https://twitter.com/CBoxTrace Twitter: https://twitter.com/Nicholaspkirby Twitter: https://x.com/1410Kinner   We Cover this Story written by Drew Koch from Blog Red Machine The internet was abuzz throughout Reds Country on Monday night with unconfirmed reports that a former All-Star could be on his way back to the city of Cincinnati. According to Mark C. Healey, Jesse Winker may be close to a deal with the Cincinnati Reds. That's certainly not the oddest thing that Reds fans have heard this offseason, and to a certain extent, reuniting with Winker would actually make a lot of sense. After two down years with the Seattle Mariners and Milwaukee Brewers, Winker resurrected his career in 2024 with stops in Washington and New York. Winker began the 2024 season with the Washington Nationals and hit .257/.374/.419 with 11 home runs and 45 RBI. The former first-round pick was then dealt to the New York Mets at the MLB trade deadline and put up a .243/.318/.365 slash line in Queens. Combined, Winker posted a .764 OPS last season and was 7-for-24 with three extra-base hits during his postseason run with the Mets. Reds Free Agency: Jesse Winker's potential return to Cincinnati has the fanbase split On the one hand, adding a power-hitter to the middle of the lineup would be a plus. The past three seasons, Winker slugged just .354, but during his five-year run in Cincinnati, Winker's slugging percentage was .504 with a 129 OPS+. Winker appeared to get back on track last season in terms of his power numbers, and the Buffalo native has always had a terrific eye at the dish. Winker was ranked in the 96th percentile last season is terms of chase rate and walk rate according to Baseball Savant. With Jonathan India now in Kansas City and Joey Votto enjoying retirement, the Reds don't have that reliable, patient hitter in the lineup who's able to draw walks and reach base with regularity. Adding a veteran like Winker whose knowledge of the strike zone is among the best in the league would undoubtedly offer an upgrade to the Reds lineup. But there's a downside to signing Winker, and that comes on the other side of the ball. Though he can play in the outfield, Winker is among the worst defenders in Major League Baseball. Last season, while splitting time as a designated hitter, Winker was worth -11 outs above average and -41 OAA for his career. For a club looking to upgrade their defense, adding Winker would seem to be a huge mistake. Whe 31-year-old also has noticeable lefty-right splits that would likely limit him to a platoon role. Last season, Winker hit just .236/.337/.337 against left-handed pitching while posting a .258/.366/.422 slash line against right-handers. Do the Reds really need another defensive liability who's also likely to sit against lefties? From a payroll standpoint, adding Winker makes sense. Few teams are likely to hand over more than a two-year deal in order to sign the longtime Reds outfielder, and the average annual value (AAV) would probably come in at less than $10 million. That's well within the scope of what the Reds could afford. There's definitely reason to believe that a reunion with Winker could work, but only if there are more moves to follow. At least Reds fans know that Winker hates Milwaukee, so he's got that going for him. Stay tuned, Reds fans. This could get interesting.

鹿児島大学の菅野康太さん(@canno696show)がゲスト。マウスのコミュニケーション研究をするに至った経緯、地方国立大での研究や心理学教育、サイエンスコミュニケーション活動について伺いました (10/30収録) Show Notes (番組HP): 菅野さん 個人HP 学部HP 菅野さんラボHP 奥山氏のNR回 1 2 鹿児島大学 法文学部人文学科 心理学コース 鹿児島大学 人文社会学研究科 公認心理師 アカデミックグルーヴ本 から派生した法人 清水修さんインタビュー SYNAPSE lab 臨床心理士 公認心理師と臨床心理士の違い 東大のサイエンスコミュニケーション副専攻 田尾さん 国立大学の中期計画 3期 4期 文系学部不要論の背景(pdf) 文科省の釈明(pdf) 九大のデジタルヒューマニティズ 半分co-メンター：田川さん 早稲田大学人間科学部 山元大輔先生 Satori遺伝子 山元先生達によるSatori関連の続報 長谷川眞理子先生 長谷川寿一先生 山内 兄人先生 性分化の研究 石浦 章一先生 による一般向けの本いろいろ 菊水先生 星野先生 岡ノ谷先生 苅郷さんの NR回 丸山工作先生 遺伝研の小出先生 高橋阿貴さん 武田先生 博士の頃のDAT研究 1 2 3 音声グルーミング仮説 Robin Dunbar ダンバー数 Nirao Shah ICRだと二匹が同時に鳴く、を明らかにした音源定位USVCAM論文 大隅先生 個性創発脳の新学術 揚妻先生 富山大の松本先生 産総研の橘さん と一緒に書いたUSVSEG論文 DeepLabCut 九工大の柴田さん 苅郷さん論文で引用された Social DefeatはIntruderにICRを使う １ 2 エンハンサーAAVの論文群 1 2 3 4 AAV関連の巨大グラント 学生向けのスクラップボックス 石山さん Brecht の研究 1 2 嫉妬？の鳴き声 動物心理学会 タッチモニタを用いたマウス実験系(pdf) 編集長である後藤さん 九州のアミュプラザ 3710Lab SILASU かごしま文化情報センター(KCIC) メディア芸術祭 山口のYCAM ゲンロンのシラス かごしま環境未来館 くらげのTシャツを着た潮合のインタビュー 担当している講義の一覧 スタンフォード監獄実験 ミルグラムの罰を与える実験 注：これら研究に関しては、結果の解釈に異論があったり、不適切な手続きの疑義があったりと、様々な議論があります。また、近年盛んに議論されている心理学の再現性問題との関連では、以下の文献など。心理学のデータと再現可能性（菅野） マンハッタンで暴動 文系のための生命科学 岡ノ谷先生の書籍 渡辺茂先生 脳神経科学イラストレイテッド 脳科学辞典 ベストティーチャー賞 近藤滋先生が自邸で行った研究 高木正勝 風に色が見えるvery uniqueなTakagiさん (appleのクリエイターインタビュー動画) 高木正勝と竹市先生のイベント 坂井克之先生 高木正勝と坂井先生のトークイベント 東北大の長神さん 情報学環の佐倉先生 toe サイエンスアゴラ

In this episode of Urban Valor, Marine veteran Brandon Hagar, a former U.S. Marine Infantryman (2017-2021, E4/Corporal), shares the tragic story of the Amphibious Assault Vehicle (AAV) mishap that resulted in the deaths of 8 Marines and 1 Navy Corpsman. Brandon, from Turlock, CA, opens up about the toxic leadership within his command, describing how constant micromanagement and leadership failures contributed to this tragic event. The AAV sinking marked one of the darkest moments in his military career, with Brandon reflecting on how it highlighted severe Marine Corps leadership issues.Brandon's journey didn't end there. Despite the trauma of his enlistment, he found a new purpose in life after leaving the Marines. Today, he helps veterans rediscover their purpose through nutrition coaching and powerlifting, supporting those struggling with their post-military lives.

TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Continued expansion of type 2 poliovirus (reliefweb) No more polio case map at polioeradication.org B/Yamagata removed from flu vaccine (NPR) Nobel Prizes for miRNA (ScienceInsider) AAV-vectored influenza vaccine (J Virol) Herpesvirus type 1 gene drive in mice (Nat Commun) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent with a crowbar Vincent – The expanding world of neuroscience Listener Pick Jason – Solar eclipse on Mars and Polaris Program and their Harmony of Resilience Ryan – New York's childhood vaccine coverage remains high Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Join us as Dr. Aravind Asokan from Duke University explores cutting-edge technologies revolutionizing advanced therapies, including CRISPR, mRNA, viral vectors, and cell therapies. He shares key lessons from past challenges, discusses scalability, product quality, and how integrating various therapeutic approaches is shaping the future of disease treatment. This episode covers exciting advancements in AAV with CRISPR, CAR T cell therapy, circular RNA, and virus-like particles (VLPs). Show notes: Asokan A, et al. ‘An evolved AAV variant enables efficient genetic engineering of murine T cells'. Cell. 2023 Jan 19;186(2):446-460. https://doi.org/10.1016/j.cell.2022.12.022

Tuesday, October 22, 2024 First Principles Genetic disease means that gene broken since conception. Novel medicines are possible ways to fix the gene - Genetic Therapies (ASO &/or AAV), this is recent, before now, kids with these diseases were a “go home and love them” situation. These are delivered via spinal tap or directly to the brain in leading medical centers. First though, regulators must approve.   Our job Develop medicines or get industry to - This is happening see Pipeline Get regulators to approve trials Get medical centers up to speed on SYNGAP1-Related Disorders (SRD) What we are building on CHOP ENDD funded externally (see #S10e92) and replicating what was built for STXBP1, check last week's webinar https://curesyngap1.org/resources/webinars/93-endd-chop-2024-syngap1/ Rare-X platform for PRO collection Regulatory pathway being made clearer every day by Stoke (Dravet), Praxis (SCN2A), Ionis (many) all of whom are working on SYNGAP1 as well.   What we are asking for We need to raise at least $500k (3rd site), preferably $1.13M (ProMMiS) Make your largest gift ever to SRF Fundraise with friends and family ACES is now ProMMiS, who knew ACE meant Adverse Childhood Event, not us. Key slides: S1 Path to Treatment | 2024 (09.27.24) 1. Why Now?  Why is it time to go from bench to bedside (research to clinical)? At least 10 companies on our pipeline not to mention multiple small molecule efforts We have limited resources – so the focus has to transition, clinical funding first. CHOP Gift is 1 year down… 2. Why NHS?Understand SYNGAP1 better, go beyond Vlaskamp 2019 and Wiltrout 2024, see #S10e105  FYI at CHOP, as I shared in #S10e151, at year 1, we are at  – 86 (Visits) + 10 (new scheduled) + 19 (2nd) + 4 (3rd)  + 22 (follow up)  Learn what to measure in clinical trials for SRD, remember our seizures are challenging Ideally we develop a Synthetic Control Arm if we use GCP Why top shelf?  We need institutions the FDA will take seriously and our children are very complex requiring experienced clinicians.  3. Why Multidisciplinary. Neuro, Psych, Genetics, PT, ST, OT, GI, Sleep, ENT, Ortho. Beyond the sheer burden of getting our kids out and about for multiple appointments the coordination by a parent is almost impossible.   4. Why Multisite/3 sites?Replicable/scalable required by regulators Accessibility (not primary reason) Establish more locations where trials will be managed Laying a foundation for a national self-sustaining network 3 is the minimum, look at STARR or Angelman, both had/ve 4. 5. How and why so fast? Because we can.  Time is Brain. Following a well trodden path SMA, Rett, Angelman, Dravet, but we are moving FASTER. 6. Does the industry really care? We are next there are so so many behind us, eager to take the resources we have access to today. Market size (Per our Census 425 US/1500 global is tip of iceberg) Multiple players reassuring each other Relatively strong amount of scientific and clinical research Haploinsufficiency (like Dravet – STOKE) – so relatively easy 7. Expensive? No. Clinical Research is more expensive than basic scientific research. Leveraging CHOP and Rare-X, setting up required networks to prepare for clinical trials.  It's time. 8. Why Bother/Help? Now is the time for SYNGAP1, we miss it at our peril. Sure, once in these places we will still see our patients, but the study, the support and the focus may pass. Our kids don't die, regardless of patient age, what we are doing can change their future and that of their loved ones and caregivers. If not us, then who? It is a rare exception when a non-family member gives a gift, and it is always because a family member asked.  We must ask. 9. What can I do? Donate to, share, join our Coast2Coast Clinics Challenge – two SYNGAP1 Squads in West and East – it's critical $500k goal by end of 2024; more than $1M needed just for the SYNGAP1ProMMiS. So far, donations from $25 to $25,000 – each and every contribution matters. This requires our entire S1 network to solicit family, friends, work colleagues, companies, etc. to contribute. Many causes out there – why not ours? Syngap.Fund/C2C   https://Syngap.Fund/C2C > https://secure.givelively.org/donate/syngap-research-fund-incorporated/coast2coast-clinics-challenge   Two teams:  https://Syngap.Fund/West & https://Syngap.Fund/East

There are over 7000 rare diseases identified in the U.S. alone. Many of these diseases affect children, leaving families desperate for answers. In this episode, we talk with one of those families and the biotech company offering them new hope. We also talk with an expert on policy that has jump-started R&D for rare diseases.Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/

Derek Jackson, vice president of cell and gene therapy product development at Pacira BioSciences, joins The Issue to take the program in a different direction. We often focus our discussions on CGT for rare diseases. Most of the time, the teams of scientists working on the program don't have any personal experience with the disease from their family, friends, or themselves.. but today we will talk about gene therapy development for a much more common disease: knee osteoarthritis. Moreover, the product we will be discussing is not only non-rare but also non-AAV.  Music by: https://www.steven-obrien.net/--------------------------Bright New Morning - Steven O'Brien (Used for free under a Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/)Show your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

MORITZ SEIDER HAS SIGNED! Steve Yzerman locks up the remaining pillar of the Detroit Red Wings core and decides that the Winged Wheel Podcast offseason ends a week early!   Tune in as we break down the huge news of Moritz Seider's 7 year, 8.55 million AAV contract to keep him in Hockeytown long term: overall value, how it compares to the likes of Faber, Sanderson, Power, and others, where he stacks up among the highest paid defensemen in the league like Makar and Dahlin, how the 7 vs. 8 year deal staggers him from Lucas Raymond and matches him with Dylan Larkin, what to expect from him in the future, whether Simon Edvinsson or Ben Chiarot can act as a support moving forward in Derek Lalonde's system, & more (3:45). After that, we discuss Detroit's playoffs and Stanley Cup window, what Steve Yzerman has to do to add to the core 3 plus Kane, Tarasenko, DeBrincat, Johansson, Danielson, Mazur, Sandin Pellikka, Brandsegg-Nygard, Cossa, & others, & whether they need a superstar like Marner or Rantanen (36:15). Next, a quick update on Detroit Red Wings Training Camp in Traverse City (50:15), as well as NHL news (including Crosby's deal, expansion, Utah, & more) (53:00) before we take your questions & comments in our Overtime segment (1:00:05) - enjoy the show! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! Max's Articles: https://www.nytimes.com/athletic/5579280/2024/09/19/red-wings-moritz-seider-contract-extension/ https://www.nytimes.com/athletic/5779754/2024/09/19/red-wings-training-camp-seider-berggren-kane/ FACTOR MEALS: Go to FactorMeals.com/WingedWheel50 to get 50% off your first box plus 20% off your next month while your subscription is active! #ad

LUCAS RAYMOND IS STAYING IN HOCKEYTOWN FOR 8 MORE YEARS! Tune into this MASSIVE episode (which features Max Bultman of The Athletic Detroit, new contributor to the Winged Wheel Podcast) as we discuss the extremely well-timed news of Lucas Raymond's 8 year, $8,075,000 AAV contract extension that Steve Yzerman locked in: overall value, what this means for Raymond's future, how he compares to Seth Jarvis and Tim Stutzle, how this works for the Detroit Red Wings salary cap now and in the future, expectations for Raymond alongside Larkin, Patrick Kane, Alex DeBrincat, Tarasenko, Compher, & others, & SO much more (3:30). We then discuss Jonatan Berggren's 1 year contract at $825k, what he needs to do to crack Derek Lalonde's Red Wings roster, comparisons to Sprong, & more (25:50). Next, the elephant in the room: what does this mean for Moritz Seider's contract? Is it soon to follow? Will he take up all (or more) of Detroit's remaining cap space, surpass Larkin, or sign in time to make training camp in Traverse City? (35:25) Finally, Max Bultman provides and update from the Prospects Tournament, including thoughts on Nate Danielson, Michael Brandsegg-Nygard, Finnie, & plenty more (52:45) before we take your questions & comments in our Overtime segment (1:04:30) - enjoy the show! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! Max's Articles: https://www.nytimes.com/athletic/5767668/2024/09/16/red-wings-prospect-tournament-michael-brandsegg-nygard/ https://www.nytimes.com/athletic/5579464/2024/09/16/red-wings-lucas-raymond-contract-extension/ FACTOR MEALS: Go to FactorMeals.com/WingedWheel50 to get 50% off your first box plus 20% off your next month while your subscription is active! #ad

The Detroit Red Wings are not far away from hitting the ice for training camp in Traverse City, and Moritz Seider, Lucas Raymond, and Jonatan Berggren are still unsigned. Tune in as we start by discussing updates (or lack thereof) on Hockeytown's unsigned RFAs, whether there's anything to be concerned about with Raymond or Seider, how this compares to the Larkin or DeBrincat situations, Steve Yzerman's negotiation tactics across the board (3:55), where Berggren's contract fits in, and  lots more (22:50). After that, Leon Draisaitl's eye-watering $14 million dollar AAV contract, how this impacts McDavid & Bouchard, & stacks up to Matthews, MacKinnon, & other superstars, & whether Edmonton is headed for a Leafs-like situation (with Marner potentially on the outs) (26:55). Also, updates on Zadina & Kubalik, thoughts on Crosby's final phase, Ducks and Utah jerseys, & lots more (46:50) before we take your questions & comments in our Overtime segment (57:35) - enjoy the show! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! HelloFresh: America's # Meal Kit. For FREE breakfast for life, go to HelloFresh.com/FreeWingedWheel. (One free breakfast item per box while subscription is active). #ad

Leon Draisaitl signed a new contract with the Edmonton Oilers that set the mark for the highest AAV in the NHL. We're joined by Oilers color commentator Bob Stauffer to discuss the new deal. Plus, we are joined by new San Jose Shark and former Oiler Cody Ceci to discuss last year's Cup run and his transition to San Jose. Join DJ Bean and Pete Blackburn for all that and more on another episode of What Chaos! presented by the ALLCITY Network! 0:00 Intro 0:45 Welcome to What Chaos! 4:45 Leon Draisaitl contract 10:47 Bob Stauffer joins 45:00 Cody & Hugo Ceci join 1:19:30 Sabres LOVE their jumbotron 1:27:00 Capitals patch madness JOIN OUR DISCORD: https://discord.gg/3brHQ2q5V2 Follow us on Twitter: https://twitter.com/WhatChaosShow https://twitter.com/DJ_Bean https://twitter.com/PeteBlackburn https://twitter.com/shawn_depaz Indeed: listeners of this show will get a $75 SPONSORED JOB CREDIT to get your jobs more visibility at https://indeed.com/allcity. Terms and conditions apply. Need to hire? You need Indeed. LUCY Nicotine: Let's level up your nicotine routine with Lucy. Go to https://lucy.co/whatchaos and use promo code (WHATCHAOS) to get 20% off your first order. Lucy offers FREE SHIPPING and has a 30-day refund policy if you change your mind. Lucy products are ONLY for adults of legal age, and every order is age-verified. WARNING: This product contains nicotine. Nicotine is an addictive chemical. Shady Rays is giving out their best deal of the season. Head to https://shadyrays.com and use code: AC35 for 35% off polarized sunglasses. Try for yourself the shades rated 5 stars by over 300,000 people. Head to https://factormeals.com/whatchaos50 and use code whatchaos50 to get 50% off! MANSCAPED: Get 20% Off and Free Shipping with code WHATCHAOS at Manscaped.com. That's 20% off and free shipping with code WHATCHAOS at Manscaped.com Download the Gametime app, create an account, and use code CHAOS for $20 off your first purchase. PrizePicks - Download the PrizePicks app today and use code WHATCHAOS for to get $50 instantly when you play $5. PrizePicks. Run your game! https://prizepicks.onelink.me/LME0/WHATCHAOS

Leon Draisaitl got PAID. The 28-year-old forward became the highest paid player in the NHL on Tuesday when he signed an eight-year, $112 million contract with the Edmonton Oilers. The $14 million AAV surpasses Auston Matthews as highest in the league. Was this an overpay? Is this the key to Edmonton getting over the hump and finally winning the Stanley Cup? Petey and Leah discuss the Draisaitl deal, the Seth Jarvis signing and the latest news around the NHL and in Arizona hockey. Plus, please join us in remembering the lives of Johnny and Matthew Gaudreau and their impact in the hockey community both on and off the ice. An ALLCITY Network Production SUBSCRIBE to our YouTube: https://bit.ly/phnx_youtube ALL THINGS PHNX: http://linktr.ee/phnxsports MERCH https://store.allcitynetwork.com/collections/phnx-locker ALLCITY Network, Inc. aka PHNX and PHNX Sports is in no way affiliated with or endorsed by the City of Phoenix PHNX Events: Get your tickets to PHNX events and takeovers here: https://gophnx.com/events/ bet365: https://www.bet365.com/olp/open-account?affiliate=365_03330244 Use the code PHNX365 to sign up, deposit $10 and choose your offer!Disclaimer: Must be 21+ and physically located in AZ.  If you or someone you know has a gambling problem and wants help, call 1-800-NEXT-STEP, text NEXTSTEP to 53342 or visit https://problemgambling.az.gov/ Empire Today: Schedule a free in-home estimate today! All listeners can receive a $350 OFF discount when they use the promo code PHNX. Restrictions apply. See https://empiretoday.com/phnx for details.Sanderson Ford: The Sanderson Ford Summer Sales Event is here and they are teaming up with the boys of summer for a final Playoff Payoff Sale. You get the payoffs like deals on 24 Ford Bronco Sport Big Bend. Lease one today for as low as $299 a month for 36 Months with only 10 percent cash down.  Branded Bills: Use code PHNX at https://www.brandedbills.com/ for 20% off your first order!  Gametime: Download the Gametime app, create an account, and use code PHNX for $20 off your first purchase.Circle K:  Join Inner Circle for free by downloading the Circle K app today! Head to https://www.circlek.com/store-locator to find Circle Ks near you!Check out FOCO merch and collectibles and use promo code “PHNX10” for 10% off your order on all non Pre Order items. Factor Mealkits: Use code PHNXYOTES50 to get 50% OFF your first Factor box and 20% off your next month with any active subscription at https://factormeals.com/phnxyotes50  Rugged Road: Gear up for your next adventure with Rugged Road Coolers - Your ultimate outdoor companion! Head to http://ruggedroadoutdoors.pxf.io/ALLCITY and use code PHNX for 10% off!  When you shop through links in the description, we may earn affiliate commissions.Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. SUBSCRIBE: https://www.youtube.com/channel/UCKaPEqS_Mc6eGNNBQN1QgQw Website:http://gophnx.com/ PHNX Locker:PHNXLocker.com SocialTwitter: @PHNX_SportsInstagram: @PHNX_Sports

Our heartfelt condolences go out to the families of Johnny Gaudreau and Matthew Gaudreau after their tragic passing. (0:00) We start this episode by discussing Seth Jarvis' new contract with the Carolina Hurricanes and the strange "new" deferral that brings the AAV down (4:15) before discussing how this might compare to Lucas Raymond's next contract & how Steve Yzerman might use it to set a price for both him and Moritz Seider (and whether he can keep them under Dylan Larkin's AAV) (3:15). After that, thoughts on Hockeytown's reported interest (alongside the Leafs) in former star Max Pacioretty before news & updates on Marco Kasper and Michael Brandsegg-Nygard in their Olympic qualification efforts, as well as Red Savage, Austin Watson, & more (23:00). Next, thoughts on Detroit being ranked 14th by the Athletic in their U23/Pipeline rankings, & whether Detroit truly lacks stars or superstars (30:15). Finally, NHL news including Jeremy Swayman's contract demands, Nick Cousins joining the Ottawa Senators, the AHL's neck protection rule, & more (44:15) before we take your questions and comments in our Overtime segment (50:35) - enjoy! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! PuckPedia Deferral: https://puckpedia.com/salary-cap/deferred Support Matthew Gaudreau's family: https://www.gofundme.com/f/support-madeline-and-baby-tripp-after-tragedy This episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/wingedwheel and get on your way to being your best self. #ad HelloFresh: America's # Meal Kit. For FREE breakfast for life, go to HelloFresh.com/FreeWingedWheel. (One free breakfast item per box while subscription is active). #ad

We have a great show for you auction fanatics as we take an early look at players AAV (average auction values) and see who is overvalued, undervalued, and correctly priced. Thank you all for tuning in for the 2024 fantasy football offseason! We hope we helped you get prepared for your fantasy football auctions! We had a blast and look forward to the 2025 season!Any questions? Email the show at absoluteauctionpodcast@gmail.com  Be sure to keep up with Adam's AAV as he continues to update it! https://fffaceoff.com/average-auction-value-aav-2024-fantasy-football/  New to auction? Ryan gives you his auction draft strategy to help prepare you: https://fffaceoff.com/auction-draft-strategies-fantasy-football-2024/Be sure to follow us X: Absolute Auction: https://x.com/FFAuctionPod Ryan Miner: https://x.com/RyanMiner_FFB Adam Segal: https://x.com/AlwaysAuctions Mark Shoe: https://x.com/primetimemock  Join our Facebook page: https://www.facebook.com/share/HJdU7SkHZuC5xbee/?mibextid=LQQJ4d

Old-Fashioned Football hosts JMark and Mir are back from vacation and ready to talk 2024 fantasy football sleepers, stashes, and busts. They start with sleepers, discussing players who have a low ADP (average draft position) and low AAV (average auction value) that they think will outperform their draft spot.The hosts then cover a couple of busts. These are players who may not necessarily have a bad year but who are being over-drafted. Which Bengals players fall on JMark's list? Which running back is Mir avoiding?Finally, the hosts give out two stash players. These are players that can be drafted towards the end of your draft and stashed on the bench until they have a potential breakout. They are $1 players that you can draft for just $1 in auction leagues, or even pick up after the draft.Also listen to the hosts answer some questions in the chat. From what they think of the Vikings' offense and Sam Darnold to which Bills' receiver they think will be the one to draft. Tune in every week and ask your questions!WhiskeyAs always, it isn't all football on Old-Fashioned Football. Today, the Old-Fashioned Football Listener Pirate League sponsored by Savage and Cooke kicked off. So, in honor of Savage and Cooke hosting, Mir makes a special Old-Fashioned using Savage and Cooke Rye. Tune in to find the recipe she used and make one of your own!Time Stamps00:00 - Intro2:50 - Injury news14:47 - Fantasy Football Sleepers40:55 - Fantasy Football Busts55:00 - Fantasy Football Stashes JOIN the SGPN community #DegensOnlyExclusive Merch, Contests and Bonus Episodes ONLY on Patreon - https://sg.pn/patreonDiscuss with fellow degens on Discord - https://sg.pn/discordDownload The Free SGPN App - https://sgpn.appCheck out the Sports Gambling Podcast on YouTube - https://sg.pn/YouTubeCheck out our website - http://sportsgamblingpodcast.comSUPPORT us by supporting our partnersPromo code FOOTBALL - 10% off everything http://sg.pn/storeUnderdog Fantasy code SGPN - Up to $1000 in BONUS CASH - https://play.underdogfantasy.com/p-sgpnFootball Contest Proxy - Use promo code SGP to save $50 at - http://proxy.footballcontest.comRithmm - Player Props and Picks - Free 7 day trial! http://sportsgamblingpodcast.com/rithmmGametime code SGPN - Download the Gametime app, create an account, and use code SGPN for $20 off your first purchase - https://gametime.co/OddsJam - 7-day free trial and 35% off your first month subscription promo code SGPN - https://fas.st/t/yaJkJgH132 NFL Team Previews - https://www.sportsgamblingpodcast.com/2024-nfl-team-previews/  ADVERTISE with SGPNInterested in advertising? Contact sales@sgpn.ioFOLLOW The Sports Gambling Podcast On Social MediaTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcastFOLLOW The Hosts On Social MediaSean Green - http://www.twitter.com/seantgreenRyan Kramer - http://www.twitter.com/kramercentric================================================================Gambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800 BETS-OFF (IA), 1-800-270-7117 for confidential help (MI)================================================================

In Hour 1… [01:37] – J.J. McCarthy Tears Meniscus Gojo and Golic react to Vikings QB J.J. McCarthy's knee injury. Even after a promising performance in one game, it might have been premature to expect McCarthy to land the starting role. The Vikings odds to win the division have improved slightly. This could be due to confidence in Darnold or the team's overall depth rather than a significant hit from McCarthy's injury. [12:20] – Packers Current WR Situation Packers head coach Matt LaFleur seems frustrated with the constant chatter about establishing a number one wide receiver. Fans and media might start to grow restless if Jordan Love struggles without a clear top target, reminiscent of the Aaron Rodgers era's frequent "weapons" discussions. LaFleur's frustration could also stem from the pressure of knowing that his job might be on the line if Love doesn't succeed. [20:53] – Aiyuk Watch: Will He Stay or Go? As the Aiyuk-to-Steelers trade talk continues, there's growing speculation that he might stay with the 49ers. If Aiyuk ends up staying, it suggests something might have shifted in San Francisco, possibly after a conversation with Shanahan. The potential deal would have significantly impacted the AFC North if he joined Pittsburgh, but staying with the Niners keeps them a top contender. His contract situation also becomes a crucial factor to watch, particularly how much guaranteed money and average annual value (AAV) he might command. [24:59] – Ja'Marr Chase Missing Practice Chase missing practice is concerning, especially if it's a sign of a longer-term holdout or injury issue. Chase's absence could slow their start, but it's still early to predict a significant impact. [30:09] – Year 2 NFL Players to Watch With only four games played in his rookie year, the ceiling is still high for Anthony Richardson, particularly with his dual-threat abilities. Bryce Young's struggles as a rookie were evident, but there's still potential for improvement. His development is critical to the Panthers' success. Boom or bust seems to be the theme with Will Levis, as he enters a critical year with a revamped Titans offense. Injuries slowed Jaxon Smith-Njigba down as a rookie, but he has a chance to emerge as Seattle's top receiving threat this year. [42:46] – Best Time Zone for Sports Viewing The debate about the best time zone for sports viewing is always interesting. Eastern: A 7 pm start is convenient, but late games can be brutal, especially with big events often ending after 10 pm. Central: Offers a slight improvement with earlier starts, but late games still push the limits. Mountain: Arguably the best balance with reasonable start and end times. Western: Morning NFL games are a dream, but early starts for big games can be problematic. -------------------------------------- Click here to subscribe, rate, and review the newest episodes of GoJo and Golic! If you or someone you know has a gambling problem, crisis counseling, and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL/IN/MI/NJ/PA/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (CO/NH), 888-789-7777/visit http://ccpg.org/chat (CT), 1-800-BETS OFF (IA), 1-877-770-STOP (7867) (LA), 877-8-HOPENY/text HOPENY (467369) (NY), visit OPGR.org (OR), call/text TN REDLINE 1-800-889-9789 (TN), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/LA/MI/NJ/ NY/PA/TN/VA/WV/WY only. New customers only. Min. $5 deposit required. Eligibility restrictions apply. See http://draftkings.com/sportsbook for details. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Now it feels like the offseason is here as the NHL & the Detroit Red Wings have quieted down (for now). Tune in as we update you on how the Winged Wheel Podcast will slow down for the summer (we're still going to be here weekly!) (0:00) before we jump into a discussion on Michael Brandsegg-Nygard's development path, whether he'll join Axel Sandin Pellikka in Skelleftea in the SHL or join the likes of Nate Danielson, Marco Kasper, Carter Mazur, and others in competing for a Detroit Red Wings or Grand Rapids Griffins spot in the AHL (5:05). After that, we loop in on the Steve Yzerman & Moritz Seider / Lucas Raymond contract negotiations, what the prospective term and AAV may be, how lessons from Auston Matthews, Mitch Marner, & Kyle Dubas in Toronto loom large, how these future stars affect the rest of Detroit's talent like Dylan Larkin, Alex DeBrincat, Patrick Kane, Simon Edvinsson, & more (13:10). Next, a quick update on Jacob Trouba (28:20) before we take a look at the Detroit Red Wings prospective lineup, where the weaknesses are as Patrick Kane and Vladimir Tarasenko may be playing with J.T. Compher, Chiarot, Seider, Johansson, & others moving around on defense, all in front of a flurry of goalies in Lyon, Talbot, Husso, & others (31:15). Finally, a quick discussion on the salary cap and no income tax states (& Barry Trotz's comments) (41:45) before we take your questions and comments during our Overtime segment (53:40) - enjoy! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! Roster Projection: https://www.nytimes.com/athletic/5624614/2024/07/09/red-wings-roster-kane-tarasenko/?source=emp_shared_article

Steve Yzerman wasn't done yet - Vladimir Tarasenko is coming to Hockeytown. Tune in as we start by analyzing the Detroit Red Wings signing Vladimir Tarasenko to a 2 year, $4.75 million AAV contract, how he fits into the forward lineup alongside Dylan Larkin, Lucas Raymond, Patrick Kane, Alex DeBrincat, & others, the deal's value & structure, how he replaces offense left by Perron, Gostisbehere, etc., & more (3:15). Next, Yzerman trading Robby Fabbri to the Anaheim Ducks for cap space (and another goalie friend for Cossa, Augustine, Campbell, Lyon, Talbot & Husso) (13:00), Joe Veleno opting for arbitration & what it means for a potential buyout (not Holl) (20:10), and the signing of Tyler Motte (25:40). After that, his press conference, including thoughts on the team's standings, chasing Stamkos or another mystery player, whether the team defense is enough to help Moritz Seider & the goalies, how Edvinsson, Johansson, and Berggren will fit in, and what roster space means for Kasper, Mazur, and Danielson (27:30). After covering the performances of key prospects & players like Brandsegg-Nygard, Sandin Pellikka, & others at the Red Wings Development Camp (52:45), we analyze the Savoie for McLeod trade between Buffalo and Edmonton (55:15) before we take your questions and comments during our Overtime segment (59:35) - enjoy! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! This episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/wingedwheeland get on your way to being your best self. #ad Development Camp Summary: https://www.nytimes.com/athletic/5618585/2024/07/05/red-wings-development-camp-nate-danielson/