Podcasts about bdellovibrio

Matters Microbial #77: It's a Germ-Eat-Germ World! February 6, 2025 Today, Dr Laura Williams, Director of Undergraduate Research at Georgia Institute of Technology, joins the #QualityQuorum to discuss some of the exciting work she did as an associate professor at Providence College with undergraduate students studying predatory bacteria and why we should care about this fascinating topic! Host: Mark O. Martin Guest: Laura Williams Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A quite ancient review article describing the different classes of predatory bacteria by yours truly. A very important article on this topic by the late Dr. Lynn Margulis and colleagues. An article about my very inspirational first microbiology professor at UCLA, Syd Rittenberg, who did early work on Bdellovibrio. Several more up to date review articles on Bdellovibrio. The website of Dr. Liz Sockett (where both yours truly and Dr. Williams received some generous training). A quite interesting article by Dr. Sockett on Bdellovibrio. An article suggesting that predatory bacteria could be used as “living antibiotics.” An article describing the BALOs concept. The article described by Dr. Williams. Dr. Williams laboratory group website. Dr. Williams current faculty/administrator page. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

We weten al dat het gebeurt sinds de jaren zestig: Bdellovibrio bacterivorous is een rovende bacteriesoort die in staat is om andere soorten op te sporen en te doden.   Dat doet de bacterie door de cel binnen te dringen en die van binnenuit op te eten, om vervolgens naar buiten te barsten.  Maar om dit te doen, moet de bacterie toegang krijgen tot het slachtoffer. Ze moeten zich op de één of andere manier hechten. Maar omdat de slachtoffers die ze kiezen enorm gevarieerd zijn, snapten onderzoekers niet hoe ze dit deden. Hoe kunnen ze zich hechten aan al die verschillende vormen?   Daar zijn ze nu achter: de bacterie heeft verschillende lange sliertachtige eiwitten op het oppervlak. Een stuk of twintig. Een beetje als een sleutelbos. Waarbij elke sleutel toegang geeft tot een ander slachtoffer. Het lukte de onderzoekers zelfs om één zo'n sleutel-slachtoffercombinatie te achterhalen. Waarom doen ze hier nou al zolang onderzoek naar en is het nieuws dat dit nu is ontdekt: snappen hoe deze bacterie dit doet, kan wellicht zorgen voor een nieuwe manier om met behulp van deze bacterie andere, voor ons schadelijke bacteriën op te sporen en te doden. Nu nog achterhalen welke sleutels bij welke sleutelgaten horen. Lees hier meer over het onderzoek: Scientists solve mystery of how predatory bacteria recognizes preySee omnystudio.com/listener for privacy information.

Today Dr. David Baltrus, Associate Professor of Plant Sciences at the University of Arizona, talks with us about how his laboratory studies bacteria that battle one another; the first rule of this fight club is that EVERYONE talks about Microbial Fight Club. Host: Mark O. Martin Guest: David Baltrus Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Here is a wonderful and easy to read essay about bacterial predators, including Bdellovibrio, from Scientific American. “2001:  A Space Odyssey” remains an important motion picture. The animated movie “The Iron Giant” is entertaining and has important messages.  Kaitlin Kariko, Drew Weissman, and the 2023 Nobel Prize in Physiology and Medicine. Jo Handelsman's wonderful “Tiny Earth” program, helping students to search for new antibiotic producing bacteria.   Elio Schaechter's absolutely essential guide/view of the changing microbial landscape in terms of organizing our knowledge. A nice introductory review of tailocins. A more exhaustive review of talocins. A really interesting article on this topic—and how tailocins might be used in agriculture— from Dr. Baltrus' laboratory. Dr. Baltrus' laboratory website can be found here. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

This episode: This episode: A bacteriophage and bacterial predator can wipe out a population of bacteria that could develop resistance to each individually! Thanks to Laura Hobley, J. Kimberley Summers, and Jan-Ulrich Kreft for their contributions!   Also a note: I will be taking a short break from podcasts while I rebuild my collection of awesome microbiology stories to talk about. Download Episode (6.8 MB, 9.9 minutes) Show notes: Microbe of the episode: Blackbird associated gemycircularvirus 1 Takeaways Bacteriophages and bacterial predators that prey on other bacteria are both very good at killing large numbers of bacteria. But bacteria as a whole are also very good at surviving being killed in large numbers; there are almost always a few that have the right genes to overcome whatever is doing the killing. This is what makes the threat of antibiotic resistance so scary, and why phage therapy is both very promising and very limited.   In this study, however, a combination of phages and the bacterial predator Bdellovibrio bacteriovorans is able to completely eradicate a population of bacteria, or at least reduce their numbers below a detectable level. A mathematical model based on these data predicts that despite the two killers working independently, they can effectively eliminate all the individual prey organisms that would otherwise be able to resist killing by either one alone. Journal Paper: Hobley L, Summers JK, Till R, Milner DS, Atterbury RJ, Stroud A, Capeness MJ, Gray S, Leidenroth A, Lambert C, Connerton I, Twycross J, Baker M, Tyson J, Kreft J-U, Sockett RE. 2020. Dual Predation by Bacteriophage and Bdellovibrio bacteriovorus Can Eradicate Escherichia coli Prey in Situations where Single Predation Cannot. J Bacteriol 202. Other interesting stories: Combination of beneficial bacteria could substitute for fertilizer somewhat (paper) Gut bacteria turn broccoli molecules into potentially healthy compounds   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

This episode: Some bacteria can defend themselves from bacterial predators by producing cyanide! Thanks to Dr. Robert Mitchell for his contribution! Download Episode (7.7 MB, 8.4 minutes) Show notes: Microbe of the episode: Dyoepsilonpapillomavirus 1 News item Journal Paper: Mun W, Kwon H, Im H, Choi SY, Monnappa AK, Mitchell RJ. 2017. Cyanide Production by Chromobacterium piscinae Shields It from Bdellovibrio bacteriovorus HD100 Predation. mBio 8:e01370-17. Other interesting stories: Using bacterial DNA to estimate movement of river water Making bacteria produce biologic drugs that last longer in the body Fungal pigment could be a useful semiconductor Parasitic microbe uses chemical defense against defenses of fungus-growing ants   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook

Chegamos ao terceiro episódio do Podcast Microbiando e nele discutimos um artigo que demonstra como bactérias que vivem na nossa pele podem produzir uma molécula que protege contra o câncer de pele. Esse artigo foi publicado na revista científica Science Advances em fevereiro de 2018 com o título “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia”. No quadro Microlitros de Notícias: uma breve pipetada de novidades da Microbiologia e Imunologia, abordamos os seguintes assuntos: a atividade do leite materno no combate à células tumorais; a utilização de bactérias vampiras contra infecções bacterianas; a descoberta de uma enzima bacteriana capaz de degradar plásticos; e algumas dicas sobre a febre amarela. Na Filogenia da Ciência, iremos trazer a história de um pesquisador muito importante para nós do Instituto de Microbiologia, o professor Paulo de Góes.   Tópicos comentados nesse episódio Microbiota Staphyloccocus epidermidis Atividade antimicrobiana Molécula 6-HAP Fármacos antitumorais Quimioterápico Tumores Prevenção do câncer de pele Leite materno no combate à células tumorais Bactérias vampiras contra infecções bacterianas Enzima bacteriana capaz de degradar plásticos Dicas sobre a febre amarela A vida de Paulo de Góes e do Instituto de Microbiologia/UFRJ   Referências desse episódio Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018 Feb 28;4(2) Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017 Feb 22;9(378). Plitzko B1, Havemeyer A1, Kunze T1, Clement B2. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol. 2002 Jul;3(7):415-24. Review. James C. S. Ho, Aftab Nadeem e Catharina Svanborg. HAMLET – A protein-lipid complex with broad tumoricidal activity. Biochemical and Biophysical Research Communications. 482: 3, 15 January 2017. Ines Ambite. HAMLET, a new concept for cancer therapy. 2017. Shatzkes, K. et al. Predatory bacteria: a new therapeutic approach for a post-antibiotic era. Future Microbiology. Maio de 2017. Shatzkes, K. et al. Examining the efficacy of intravenous administration of predatory bacteria in rats. Scientific Reports. Maio de 2017. Shatzkes, K. et al. Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model. Nature. Março de 2015. Yoshida et al. A bacterium that degrades and assimilates poly(ethylene terephthalate). Science. Março de 2016 Austin, H. P. et al. Characterization and engineering of a plastic-degrading aromatic polyesterase. PNAS.  Abril de 2018   Sobre o Podcast Microbiando A ideia do Microbiando é discutir artigos científicos de ponta em todas as áreas da microbiologia e imunologia. Vamos utilizar uma linguagem bem acessível para destrinchar esses artigos para vocês, mas sem perder o rigor científico e analítico necessário para essa tarefa. Além de discutir artigos nós teremos o quadro Microlitros de Notícias, onde nossos microbiologistas e imunologistas de plantão irão abordar pequenas reportagens e trazer novidades para vocês. No quadro filogenia da Ciência vamos contar um pouco sobre a vida de grandes personalidades que revolucionar...

Professor Liz Sockett studies an extraordinary group of predatory bacteria. Bdellovibrio may be small but they kill other bacteria with ingenious and ruthless efficiency. Liz has devoted the last fifteen years of her career as a microbiologist to work out how this microscopic killer invades and consumes its victims - victims which include a host of disease-causing bacteria which have also acquired resistance to antibiotics which once killed them. As well as studying the numerous tricks and weapons which Bdellovibrio have evolved to despatch and feed on other bugs, Prof Sockett's lab at the University of Nottingham is also testing the bacteria's potential as a new kind of treatment in the era of antibiotic resistance. Deadly infections may not be able to outwit this bacterial top predator in the way they have with ever increasing numbers of antibiotic drugs. Liz talks to Jim Al-Khalili about how a BBC TV children's show first introduced her to the superfast killer bacteria, how Roman villas led her towards a life of discovery, and how her lab in Nottingham might be compared to the kitchen of a restaurant and her team to a brigade of chefs. Producer: Andrew Luck-Baker.

Bdellovibrio is a small bacterium which preys and kills other bacteria. A team of researchers in the UK has shown in animal experiments that injections of the predator microbe can successfully treat infections. So how close does this take us to Bdellovibrio therapy for human patients and what part might it play in tackling the growing crisis of antibiotic resistance? Adam Rutherford talks to Professor Liz Sockett of the University of Nottingham. The British government has announced that it will be spending an additional £2 billion on research and development by 2020. Commentators say it is the largest hike in public funding for science in a very long time. Dr Sarah Main of the Campaign for Science and Engineering, and Dr Arnab Basu, physicist and CEO of Kromek, discuss the new money and how it would be best used. Also in the programme, materials and electronics engineers in the US have devised a small wearable heart monitor - the size and thickness of a sticking plaster. Adam talks to its lead designer Professor John Rogers of Northwestern University in Chicago. And could phobias be cured without exposure to the thing which frightens people? Dr Ben Seymour outlines an intriguing experiment which involved reading people's thoughts in a brain scanner, which suggests ultimately it may be possible.

This episode: Predatory bacteria have a particular protein that protects them from their own prey-damaging enzymes! Download Episode (7.3 MB, 7.9 minutes) Show notes: News item Journal Paper: Lambert C, Cadby IT, Till R, Bui NK, Lerner TR, Hughes WS, Lee DJ, Alderwick LJ, Vollmer W, Sockett RE, Lovering AL. 2015. Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nat Commun 6:8884. Other interesting stories: Bacterial proteins could be used to break open cells upon command Animal gut fungi could break down plant material for biofuels Fungal partners help determine which trees can grow in a forest Parasitic fungi contribute to ocean algae turnover (paper) Fungus in tree inhibits other fungi and plants (paper)   Post questions or comments here or email to bacteriofiles at gmail dot com. Thanks for listening! Subscribe at iTunes or Google Play, check out the show at Twitter or Facebook  

Since the epic flyby of Pluto in July, NASA has been regularly downloading staggering images from the New Horizons mission. Pluto is not a dead rock, but a geologically active dwarf planet, with tectonic movements, ice plains, glaciers, dunes and cryo-volcanoes. For an end of year update on the observations and outstanding mysteries, Adam meets Alan Stern, the Principal Investigator on New Horizons, who is still marvelling at the success of this humble craft. Scientists have discovered how a potentially useful predatory bacterium called Bdellovibrio protects itself against its own weapons when it invades other bacteria. Professor Liz Sockett discusses how the work offers insights into early steps in the evolution of bacterial predators and how this will help to inform new ways to fight antimicrobial resistance Science stops for no one .So how are researchers nurturing their experiments over the festive period? Marnie Chesterton has gone on the hunt for scientists for whom Christmas Day will be yet another day in the lab. This year there's has been an explosion of papers of using DNA to reconstruct human history. We've invented new techniques for extracting DNA from the long dead, and for analysing ancient genomes. Professor Matthew Cobb from the University of Manchester assesses recent key developments in reconstructing the lives and population structures of ancient civilisations. Producer Adrian Washbourne

This Day in Skepticism: 9/11; News items: Motivated Numeracy, Arctic Ice, Robot Traders, Teenage Exorcists, Homeopathic Vaccines, Mission to Mars; Who's That Noisy; Your Questions and E-mails: Bdellovibrio; Science or Fiction

This Day in Skepticism: 9/11; News items: Motivated Numeracy, Arctic Ice, Robot Traders, Teenage Exorcists, Homeopathic Vaccines, Mission to Mars; Who's That Noisy; Your Questions and E-mails: Bdellovibrio; Science or Fiction

This episode: A study of the bacteria-hunting Bdellovibrio life cycle! Download Episode (4.45 MB, 5 minutes)Show notes:Journal Commentary/Journal paper/Movies of Bdellovibrio Other interesting stories: How a probiotic product reduces inflammation Using bacteria to clean up pollution Swimming of ocean microbes contributes to nutrient cycling How gut microbiota composition is shaped Bacteria make good decisions Post questions or comments here or email to bacteriofiles at gmail dot com This e-mail address is being protected from spambots. You need JavaScript enabled to view it . Thanks for listening! Subscribe at iTunes, check out the show at Twitter or SciencePodcasters.org