Podcast appearances and mentions of nat commun

Christopher Bae is taking us on a journey to meet the hominids of Asia's past. Dr. Bae is a distinguished paleoanthropologist from the University of Hawai'i at Mānoa whose research focuses on human evolution in East Asia. Born in Korea and adopted by an American family, his unique personal journey sparked an early interest in race, human variation, and the deep history of our species. What began as a search for his own roots led him to a career dedicated to reconstructing the past—much like paleoanthropologists do when piecing together humanity's evolutionary story. Dr. Bae has conducted extensive field and laboratory research across Korea, Japan, and China, collaborating on projects that span hominin fossils, vertebrate taphonomy, and lithic analysis. His work bridges disciplines in the social and natural sciences, providing a comprehensive perspective on Pleistocene hominin morphological and behavioral variation, particularly in Homo erectus and both archaic and modern Homo sapiens. With approximately 150 publications and over $1.5 million in extramural funding, Dr. Bae is a leading voice in understanding human evolution in East Asia. ------------------------------ Find the papers discussed in this episode: Bae, C. J., Liu, W., Wu, X., Zhang, Y., Ni, X. (2023). "Dragon man" prompts rethinking of Middle Pleistocene hominin systematics in Asia. Innovation (Camb), 4(6):100527. doi: 10.1016/j.xinn.2023.100527. Bae, C.J., Wu, X. Making sense of eastern Asian Late Quaternary hominin variability. Nat Commun 15, 9479 (2024). https://doi.org/10.1038/s41467-024-53918-7 Contact Dr. Bae: cjbae@hawaii.edu ------------------------------ Contact the Sausage of Science Podcast and Human Biology Association: Facebook: facebook.com/groups/humanbiologyassociation/, Website: humbio.org, Twitter: @HumBioAssoc Chris Lynn, Co-Host Website: cdlynn.people.ua.edu/, E-mail: cdlynn@ua.edu, Twitter:@Chris_Ly Courtney Manthey, Guest Co-Host, Website: holylaetoli.com/ E-mail: cpierce4@uccs.edu, Twitter: @HolyLaetoli Anahi Ruderman, Guest Co-Host , SoS Co-Producer, HBA Junior Fellow, E-mail: aniruderman@gmail.com, Twitter: @ani_ruderman

Consider this: Stress will likely surge higher when you are uncertain about an outcome compared to when you're faced with a certainly bad outcome. Sounds wild, right?! Think about the scenarios though... Would you rather be told you're going to lose your job next month or have your boss tell you that there's a 50-50 chance you'll lose it during the next month? In those 50-50 scenarios, we can get stuck in a cycling stress response and no clear idea of what to do next to alleviate it. At least if you know you're going to lose your job, you have a clear next step: start job hunting. That's what we're digging into in this episode. We'll explore different types of uncertainty (estimation uncertainty, irreducible uncertainty, and volatility), why we stress over the unknown, and how to navigate these experiences in everyday life. Sources and Notes: Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. de Berker, A., et al. (2016). Computations of uncertainty mediate acute stress responses in humans. Nat Commun 7, 10996. Access here.  Pema Chödrön quote: " To be fully alive, fully human, and completely awake is to be continually thrown out of the nest. To live fully is to be always in no man's land, to experience each moment as completely new and fresh. To live is to be willing to die over and over again." Full transcript here. Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Welcome to the PRESSURISED version of episode 58, just the science, none of the waffle   We are still talking about Antarctica, the continent that keeps on giving!   For this month's interview, we speak with Devin Harrison - Marine Geoscientist/Postdoctoral Researcher at Kelpie Geoscience - Devin is a postdoctoral research fellow at Kelpie Geoscience. His research utilises high-resolution topographic models of the seafloor and complementary geophysical and geospatial datasets to understand the geomorphic evolution and process landform relationship of the deep sea and the continental shelves. Devin is particularly interested in the glacial geomorphological record and the evolution of glacial environments from the last glacial maximum (~20-25 thousand years ago) to the present day.   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Elena Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here!   Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@deepseapod.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com Twitter: @DeepSeaPod Instagram: @deepsea_podcast   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  Inkfish - @inkfishexpeditions BlueSky: Thom @thomaslinley.com   Reference list Dowdeswell, J.A., Canals, M., Jakobsson, M., Todd, B.J., Dowdeswell, E.K. and Hogan, K. (eds.), 2016. Atlas of Submarine Glacial Landforms: Modern, Quaternary and Ancient, The Geological Society of London, London. vol. 46, 618pp. doi:10.1144/M46.   Batchelor, C.L., Christie, F.D.W., Ottesen, D., Montelli, A., Evans, J., Dowdeswell, E.K., Bjarnadóttir, L.R. and Dowdeswell, J.A., 2023. Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day. Nature, vol. 617, issue 7959, p.105-110. Doi:10.1038/s41586-023-05876-1.     Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019).   Seafloor surficial sediment variability across the abyssal plains of the central and eastern Pacific Ocean   Credits Theme: Hadal Zone Express by Märvel Logo image: Lance Wordsworth (Inkfish Media)

Jan arbeitet dann, wenn andere noch schlafen oder schon längst Feierabend haben: Er arbeitet im Schichtdienst. Ihm gefällt die Abwechslung. Für die innere Uhr ist Schichtarbeit weniger optimal. Und auch für die Freizeit kann sie eine Herausforderung sein.**********Ihr hört: Gesprächspartner: Jan, Kraftfahrer, Straßen- und Grünflächenreiniger Gesprächspartnerin: Daniela Tieves-Sander, Soziologin und Arbeitsschützerin bei der IG Metall, hat über die Auswirkungen von Schichtarbeit promoviert Gesprächspartner: Volker Harth, Professor für Arbeitsmedizin und Maritime Medizin, Universitätsklinikum Hamburg-Eppendorf Autor und Host: Przemek Żuk Redaktion: Stefan Krombach, Lena Mempel, Lara Lorenz, Friederike Seeger Produktion: Alexander Hardt**********Quellen:Arlinghaus, A. & Lott, Y. (2018). Schichtarbeit gesund und sozialverträglich gestalten. Nr. 3 Forschungsförderung Report. Hans-Böckler-Stiftung. Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (2022). Arbeitszeitreport Deutschland: Ergebnisse der BAuA-Arbeitszeit­befragung 2021.Harth, V. (Koor.) & Terschüren, C. (Co-Koor.) (2021). Leitlinie "Gesundheitliche Aspekte und Gestaltung von Nacht- und Schichtarbeit". Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin.Rodenbeck, A., Mayer, G. (2023). Schichtarbeit. Somnologie 27, S. 216–225.Chellappa, S.L., Gao, L., Qian, J. et al. (2025). Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial. Nat Commun 16, 3186.**********Mehr zum Thema bei Deutschlandfunk Nova:Schichtarbeit: Wie schlafen wir, wenn wir nachts arbeiten?Schlaf erforschen: "Für Schichtarbeit sind wir nicht gemacht"Nachtschicht: Tipps, um wach und fit zu bleiben**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

We are still talking about Antarctica, the continent that keeps on giving! Alan and Thom discuss trying to stop working momentarily, constructing a treehouse, and acquiring a shark. In the news, we rattle off a list of newly discovered species with some very cool (but hard to pronounce) names. There has been a lot of squiddy news. Footage of divers swimming with a giant squid has resurfaced; in an exclusive for the podcast, Alan has recorded more amazing Magnapinna (bigfin or elbow squid) footage. And the biggest bit of news: the colossal squid has been seen alive in its natural habitat for the first time! Thom and Kat were part of the press conference. Megalodon (the not-deep-sea and very extinct shark) has been reassessed based on what we do know. It was likely longer and slimmer than we thought, and we have estimations for their speed and size at birth. We also have a new coelacanth population and a classic car found in the deep.   For this month's interview, we speak with Devin Harrison - Marine Geoscientist/Postdoctoral Researcher at Kelpie Geoscience - Devin is a postdoctoral research fellow at Kelpie Geoscience. His research utilises high-resolution topographic models of the seafloor and complementary geophysical and geospatial datasets to understand the geomorphic evolution and process landform relationship of the deep sea and the continental shelves. Devin is particularly interested in the glacial geomorphological record and the evolution of glacial environments from the last glacial maximum (~20-25 thousand years ago) to the present day.   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Elena Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here!   Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@deepseapod.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com Twitter: @DeepSeaPod Instagram: @deepsea_podcast   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  Inkfish - @inkfishexpeditions BlueSky: Thom @thomaslinley.com   Follow Kat on  Bluesky: @autsquidsquad.bsky.social Twitter: @ALCESonline   Reference list News New Species A new species of hound shark from the northern Indian ocean, Iago goplakrishnani   New genus and species of feather duster worm from the hydrocarbon seeps in the Gulf of Mexico. – Seepicola viridiplumi Five new trench isopods in the Haploniscus belyaevi complex. And a new dumbo octopis, Grimpoteuthis feitiana   Megalodon New paper on the meg Tyler Greenfield's blog   Divers swim with giant squid Divers Encounter a Live Giant Squid Swimming on the Ocean Surface https://youtu.be/gZxGGQc_hRI?si=ZmRhwaIF2T9RV-Lk – original video   The colossal squid has been seen! Original video with Kat's voiceover Kat's piece in The Conversation   Deep-sea classic car   Interview Dowdeswell, J.A., Canals, M., Jakobsson, M., Todd, B.J., Dowdeswell, E.K. and Hogan, K. (eds.), 2016. Atlas of Submarine Glacial Landforms: Modern, Quaternary and Ancient, The Geological Society of London, London. vol. 46, 618pp. doi:10.1144/M46.   Batchelor, C.L., Christie, F.D.W., Ottesen, D., Montelli, A., Evans, J., Dowdeswell, E.K., Bjarnadóttir, L.R. and Dowdeswell, J.A., 2023. Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day. Nature, vol. 617, issue 7959, p.105-110. Doi:10.1038/s41586-023-05876-1.     Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019). https://doi.org/10.1038/s41467-019-13496-5   Seafloor surficial sediment variability across the abyssal plains of the central and eastern Pacific Ocean https://www.frontiersin.org/journals/earth-science/articles/10.3389/feart.2025.1527469/full   Credits Theme: Hadal Zone Express by Märvel Logo image: Lance Wordsworth (Inkfish Media) Song of the month: The Midnight Zone by SLADE

Von Hormonproduktion über Verdauung bis hin zur Energieverwertung: Der circadiane Rhythmus beeinflusst fast alle physiologischen Funktionen. Wenn wir im Einklang mit unserer inneren Uhr leben, funktioniert unser Körper effizienter und Verdauungsprobleme können besser gelöst werden. ShownotesIn dieser Folge dreht sich alles um den Zusammenhang von Stoffwechsel und zirkadianem Rhythmus. Ich teile meine wichtigsten Erkenntnisse, die dir helfen können, Verdauungsprobleme gezielt anzugehen, deine Ernährung in Einklang mit natürlichen Rhythmen zu bringen und kleine Veränderungen stressfrei in deinen Alltag zu integrieren - auch, wenn du zum Beispiel im Schichtdienst arbeitest. Dafür werfen wir einen Blick auf moderne wissenschaftliche Erkenntnisse und verbinden diese mit dem individuellen Ansatz des Ayurveda, um mit statt gegen unseren Körper zu arbeiten.In dieser Folge erfährst duWie der zirkadiane Rhythmus auf biologischer Ebene funktioniertWie dieser Rhythmus sich auf deine (Verdauungs-)hormone und deinen Stoffwechsel auswirktWie der Ayurveda und die aktuelle wissenschaftliche Studienlage die Relevanz des zirkadianen Rhythmus für unsere Essenszeiten bewertenWelche gesundheitlichen Folgen es haben kann, wenn wir gegen unsere innere Uhr lebenWelche Essenszeiten ideal sind und wie du deinen Stoffwechsel mit der idealen Mahlzeitenzusammensetzung unterstützen kannst (das geht auch, wenn du z. B. im Schichtdienst arbeitest)Konntest du etwas für dich mitnehmen? Dann würde ich mich riesig über deinen Like freuen.

It's the last in our run of episodes about Antarctica. We are all back home, and we promise to stop bothering the poor continent.   Thom couldn't talk about it until after the press release, but the Schmidt Ocean Institute cruise he was on had to look at the seabed under a 150-meter-thick ice shelf right as it moved out of the way. We talked to the science leads on that cruise, Patricia Esquete and Sasha Montelli. We learned about the hydrography and glaciology of that region and then the seabed and communities that were revealed when the ice shelf moved away.   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Ryker and Kerry Jowett  Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here! Which now includes Alan's beloved apron and a much anticipated new design...    Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@armatusoceanic.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com https://bsky.app/profile/deepseapod.com   Twitter: @DeepSeaPod https://twitter.com/DeepSeaPod   Facebook: DeepSeaPodcast https://www.facebook.com/DeepSeaPodcast   Instagram: @deepsea_podcast https://www.instagram.com/deepsea_podcast/   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  BlueSky: Thom @thomaslinley.com   Follow Sasha on Twitter: @sasha_montelli Reference list Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019). https://doi.org/10.1038/s41467-019-13496-5 Helen Amanda Fricker et al., Antarctica in 2025: Drivers of deep uncertainty in projected ice loss.Science387,601-609(2025).DOI:10.1126/science.adt9619 https://www.science.org/doi/10.1126/science.adt9619 Ingels, J., Aronson, R.B., Smith, C.R., Baco, A., Bik, H.M., Blake, J.A., Brandt, A., Cape, M., Demaster, D., Dolan, E. and Domack, E., 2021. Antarctic ecosystem responses following ice‐shelf collapse and iceberg calving: Science review and future research. Wiley Interdisciplinary Reviews: Climate Change, 12(1), p.e682. https://wires.onlinelibrary.wiley.com/doi/am-pdf/10.1002/wcc.682   Challenger 150 - Home - Challenger 150   The Ocean Census | Discover Life   Credits Theme: Hadal Zone Express by Märvel

Von Hormonproduktion über Verdauung bis hin zur Energieverwertung: Der circadiane Rhythmus beeinflusst fast alle physiologischen Funktionen. Wenn wir im Einklang mit unserer inneren Uhr leben, funktioniert unser Körper effizienter und Verdauungsprobleme können besser gelöst werden. ShownotesIn dieser Folge dreht sich alles um den Zusammenhang von Stoffwechsel und zirkadianem Rhythmus. Ich teile meine wichtigsten Erkenntnisse, die dir helfen können, Verdauungsprobleme gezielt anzugehen, deine Ernährung in Einklang mit natürlichen Rhythmen zu bringen und kleine Veränderungen stressfrei in deinen Alltag zu integrieren - auch, wenn du zum Beispiel im Schichtdienst arbeitest. Dafür werfen wir einen Blick auf moderne wissenschaftliche Erkenntnisse und verbinden diese mit dem individuellen Ansatz des Ayurveda, um mit statt gegen unseren Körper zu arbeiten.In dieser Folge erfährst duWie der zirkadiane Rhythmus auf biologischer Ebene funktioniertWie dieser Rhythmus sich auf deine (Verdauungs-)hormone und deinen Stoffwechsel auswirktWie der Ayurveda und die aktuelle wissenschaftliche Studienlage die Relevanz des zirkadianen Rhythmus für unsere Essenszeiten bewertenWelche gesundheitlichen Folgen es haben kann, wenn wir gegen unsere innere Uhr lebenWelche Essenszeiten ideal sind und wie du deinen Stoffwechsel mit der idealen Mahlzeitenzusammensetzung unterstützen kannst (das geht auch, wenn du z. B. im Schichtdienst arbeitest)Konntest du etwas für dich mitnehmen? Dann würde ich mich riesig über deinen Like freuen.

It's the last in our run of episodes about Antarctica. We are all back home, and we promise to stop bothering the poor continent. Alan and Thom discuss returning to an inbox of horrors and readjusting to time away. More cable cutting in our news updates, blobfish being voted fish of the year, and the tongue-eating louse potentially being invertebrate of the year. We don't want to say we influence the news, but it seems a little spooky. Thom couldn't talk about it until after the press release, but the Schmidt Ocean Institute cruise he was on had to look at the seabed under a 150-meter-thick ice shelf right as it moved out of the way. We talked to the science leads on that cruise, Patricia Esquete and Sasha Montelli. We learned about the hydrography and glaciology of that region and then the seabed and communities that were revealed when the ice shelf moved away. Kat and Thom updated us on what it was like to join a tourist expedition ship, and we grabbed a Coffee With Andrew to learn what it was like to dive almost 5km deep in a sub. You're bound to leave this episode with a watery smile!   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Ryker and Kerry Jowett  Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here! Which now includes Alan's beloved apron and a much anticipated new design...    Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@armatusoceanic.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com https://bsky.app/profile/deepseapod.com   Twitter: @DeepSeaPod https://twitter.com/DeepSeaPod   Facebook: DeepSeaPodcast https://www.facebook.com/DeepSeaPodcast   Instagram: @deepsea_podcast https://www.instagram.com/deepsea_podcast/   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  BlueSky: Thom @thomaslinley.com   Follow Sasha on Twitter: @sasha_montelli   Follow Kat on  Bluesky: @autsquidsquad.bsky.social https://bsky.app/profile/autsquidsquad.bsky.social Twitter: @ALCESonline https://x.com/ALCESonline     Reference list News Cable cutting https://www.rnz.co.nz/news/political/545872/the-new-threat-to-the-undersea-cables-keeping-our-internet-going https://www.submarinecablemap.com/ https://www.bbc.co.uk/sounds/play/w3ct7yqx   Blobfish fish of the year https://www.stuff.co.nz/nz-news/360621538/worlds-ugliest-animal-named-new-zealands-fish-year   Invertebrate of the year ‘Unique and important': Tongue-biting louse is wonderfully gruesome | Marine life | The Guardian   Interview Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019). https://doi.org/10.1038/s41467-019-13496-5 Helen Amanda Fricker et al., Antarctica in 2025: Drivers of deep uncertainty in projected ice loss.Science387,601-609(2025).DOI:10.1126/science.adt9619 https://www.science.org/doi/10.1126/science.adt9619 Ingels, J., Aronson, R.B., Smith, C.R., Baco, A., Bik, H.M., Blake, J.A., Brandt, A., Cape, M., Demaster, D., Dolan, E. and Domack, E., 2021. Antarctic ecosystem responses following ice‐shelf collapse and iceberg calving: Science review and future research. Wiley Interdisciplinary Reviews: Climate Change, 12(1), p.e682. https://wires.onlinelibrary.wiley.com/doi/am-pdf/10.1002/wcc.682   Challenger 150 - Home - Challenger 150   The Ocean Census | Discover Life   Other Journal Minerva – Diving into Relevance: How Deep Sea Researchers Articulate Societal Relevance within their Epistemic Living Spaces s11024-025-09577-z.pdf   Credits Theme: Hadal Zone Express by Märvel Logo image: ROV SuBastian / Schmidt Ocean Institute creative commons Attribution-NonCommercial-ShareAlike CC BY-NC-SA https://creativecommons.org/licenses/by-nc-sa/4.0/

A Rebelião Saudável nasceu da união de diversos profissionais de saúde que pensam diferente e cujo foco é promover saúde e bem estar, com comida de verdade e sem medicamentos.Semanalmente a Rebelião se reune no app Telegram para discussão de tópicos importantes relacionados a Nutrição Humana e Qualidade de vida. Nessa semana, conversamos sobre Fibras: Será que são Essenciais?Referências:Ho KS, Tan CY, Mohd Daud MA, Seow-Choen F. Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms. World J Gastroenterol. 2012 Sep 7;18(33):4593-6.Frost GS, Brynes AE, Dhillo WS, Bloom SR, McBurney MI. The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. Eur J Clin Nutr. 2003 Feb;57(2):293-8.Schnorr SL, Candela M, Rampelli S, Centanni M, Consolandi C, Basaglia G, Turroni S, Biagi E, Peano C, Severgnini M, Fiori J, Gotti R, De Bellis G, Luiselli D, Brigidi P, Mabulla A, Marlowe F, Henry AG, Crittenden AN. Gut microbiome of the Hadza hunter-gatherers. Nat Commun. 2014 Apr 15;5:3654. doi: 10.1038/ncomms4654. PMID: 24736369; PMCID: PMC3996546.

Continuing the end of year 2024 edition of Unearthed!, this installment includes these categories: potpourri, edibles and potables, and books and letters Research: Giuffrida, Angela. “Painting found by junk dealer in cellar is original Picasso, experts claim.” The Guardian. 10/1/2024. https://www.theguardian.com/artanddesign/2024/oct/01/painting-found-by-junk-dealer-in-cellar-is-original-picasso-experts-claim Lawson-Tancred, Jo. “‘Horrible’ Painting Found by a Junk Dealer Could Be a Picasso Worth $6 Million.” ArtNet. 10/1/2024. https://news.artnet.com/art-world/junk-dealer-picasso-2545786 Kuta, Sarah. “This Shipwreck’s Location Was a Mystery for 129 Years. Then, Two Men Found It Just Minutes Into a Three-Day Search.” Smithsonian. 9/30/2024. https://www.smithsonianmag.com/smart-news/this-shipwrecks-location-was-a-mystery-for-129-years-then-two-men-found-it-just-minutes-into-a-three-day-search-180985165/ Peru murals https://archaeology.org/news/2024/10/01/additional-moche-murals-uncovered-in-peru-at-panamarca/ Leung, Maple. “Team makes distilled wine in replica of bronze vessel found at emperor’s tomb.” MyNews. 12/13/2024. https://www.scmp.com/news/china/science/article/3290709/team-makes-distilled-wine-replica-bronze-vessel-found-emperors-tomb Feldman, Ella. “Dorothy’s Ruby Slippers From ‘The Wizard of Oz’ Sell for a Record-Breaking $28 Million.” Smithsonian. 12/10/2024. s-from-the-wizard-of-oz-sell-for-a-record-breaking-28-million-180985620/ Tamisiea, Jack. “Hairballs Shed Light on Man-Eating Lions’ Menu.” The New York Times. 10/11/2024. https://www.nytimes.com/2024/10/11/science/tsavo-lions-man-eating-dna.html Spears, Nancy Marie. “First-ever oral histories of Indian boarding school survivors, collected with care.” ICT. 10/16/2024. https://ictnews.org/news/first-ever-oral-histories-of-indian-boarding-school-survivors-collected-with-care Kuta, Sarah. “Biden Issues a ‘Long Overdue’ Formal Apology for Native American Boarding Schools.” Smithsonian. 10/25/2024. https://www.smithsonianmag.com/smart-news/biden-issues-a-long-overdue-biden-formally-apologizes-for-native-american-boarding-schools-180985341/ Schrader, Adam. “A New Monument Confronts the Dark Legacy of Native American Boarding Schools.” ArtNet. 12/13/2024. https://news.artnet.com/art-world/indian-boarding-school-national-monument-2586044 Boucher, Brian. “This Contemporary Artist Will Complete a Missing Scene in the Millennium-Old Bayeux Tapestry.” Artnet. 10/29/2024. https://news.artnet.com/art-world/helene-delprat-complete-bayeux-tapestry-2560937 Reuters. “Ancient Pompeii site uncovers tiny house with exquisite frescoes.” 10/24/2024. https://www.reuters.com/world/europe/ancient-pompeii-site-uncovers-tiny-house-with-exquisite-frescoes-2024-10-24/ The History Blog. “Tiny house frescoed like mansion in Pompeii.” 10/25/2024. http://www.thehistoryblog.com/archives/71444 Bowman, Emma. “New DNA evidence upends what we thought we knew about Pompeii victims.” NPR. 11/9/2024. https://www.npr.org/2024/11/08/g-s1-33553/pompeii-dna-evidence-vesuvius-victims Benzine, Vittoria. “Pompeii Experts Back Up Pliny’s Historical Account of Vesuvius Eruption.” ArtNet. 12/13/2024. https://news.artnet.com/art-world/pompeii-pliny-vesuvius-eruption-date-2587228 Willsher, Kim. “‘Bodies were dropped down quarry shafts’: secrets of millions buried in Paris catacombs come to light.” The Guardian. 10/19/2024. https://www.theguardian.com/world/2024/oct/19/bodies-quarry-shafts-millions-buried-paris-catacombs Kuta, Sarah. “See the Wreck of Ernest Shackleton’s ‘Endurance’ in Astonishing Detail With This New 3D Scan.” Smithsonian. 10/18/2024. https://www.smithsonianmag.com/smart-news/see-the-wreck-of-ernest-shackletons-endurance-in-astonishing-detail-with-this-new-3d-scan-180985274/ Boucher, Brian. “In a Rare Move, Boston’s Gardner Museum Snaps Up a Neighboring Apartment Building.” ArtNet. 10/18/2024. https://news.artnet.com/art-world/boston-gardner-museum-buys-apartment-building-2555811 Whipple, Tom. “Letters reveal the quiet genius of Ada Lovelace.” The Times. 6/14/2024. https://www.thetimes.com/uk/history/article/ada-lovelace-letters-shed-light-woman-science-1848-kdztdh9x0 Lawson-Tancred, Jo. “This 18th-Century Painting Could Rewrite Black History in Britain.” ArtNet. 10/14/2024. https://news.artnet.com/art-world/this-18th-century-painting-could-rewrite-black-history-in-britain-2552814 Factum Foundation. “William Blake’s Earliest Engravings.” 2024. https://factumfoundation.org/our-projects/digitisation/archiox-analysing-and-recording-cultural-heritage-in-oxford/william-blakes-earliest-engravings/ Whiddington, Richard. “William Blake’s Earliest Etchings Uncovered in Stunning High-Tech Scans.” ArtNet. 10/23/2024. https://news.artnet.com/art-world/william-blake-earliest-engravings-copper-plates-bodleian-2558053 Kinsella, Eileen. “X-Ray Analysis of Gauguin Painting Reveals Hidden Details… and a Dead Beetle.” ArtNet. 12/2/2024. https://news.artnet.com/art-world/gauguin-little-cat-analysis-van-gogh-museum-2577081 Oster, Sandee. “Archaeologists reveal musical instruments depicted in Zimbabwe's ancient rock art.” Phys.org. 11/29/2024. https://phys.org/news/2024-11-archaeologists-reveal-musical-instruments-depicted.html Niskanen, Niina. “Prehistoric hunter-gatherers heard the elks painted on rocks talking.” EurekAlert. 11/25/2024. https://www.eurekalert.org/news-releases/1065949 Metcalfe, Tom. “WWII British sub that sank with 64 on board finally found off Greek Island.” LiveScience. https://www.livescience.com/archaeology/wwii-british-sub-that-sank-with-64-on-board-finally-found-off-greek-island Medievalists.net. “Tudor Sailors’ Bones Reveal Link Between Handedness and Bone Chemistry.” https://www.medievalists.net/2024/11/tudor-sailors-bones-reveal-link-between-handedness-and-bone-chemistry/ Benzine, Vittoria. “Astonishing Trove of Rare Roman Pottery Uncovered Beneath Sicilian Waters.” 11/7/2014. https://news.artnet.com/art-world/rare-richborough-pottery-underwater-sicily-2565780 Kuta, Sarah. “Divers Recover 300-Year-Old Glass Onion Bottles From a Shipwreck Off the Coast of Florida.” Smithsonian. 10/31/2024. https://www.smithsonianmag.com/smart-news/divers-recover-300-year-old-glass-onion-bottles-from-a-shipwreck-off-the-coast-of-florida-180985358/ Babbs, Verity. “This Sunken Ship May Be the 1524 Wreckage From Vasco da Gama’s Final Voyage.” ArtNet. 11/30/2024. https://news.artnet.com/art-world/sunken-ship-vasco-da-gama-2577760 Roberts, Michael. “Researchers locate WWI shipwreck off Northern Ireland.” PhysOrg. 12/3/2024. https://phys.org/news/2024-12-wwi-shipwreck-northern-ireland.html ACS Newsroom. “New hydrogel could preserve waterlogged wood from shipwrecks.” EurekAlert. 12/3/2024. https://www.eurekalert.org/news-releases/1066769 Dedovic, Yaz. “Bad weather led Dutch ship into Western Australian coast.” EurekAlert. 12/8/2024. https://www.eurekalert.org/news-releases/1067496 Bassi, Margherita. “1,200 years ago, a cat in Jerusalem left the oldest known evidence of 'making biscuits' on a clay jug.” LiveScience. 8/28/2024. https://www.livescience.com/archaeology/1-200-years-ago-a-cat-in-jerusalem-left-the-oldest-known-evidence-of-making-biscuits-on-a-clay-jug Oster, Sandee. “Tunisian snail remains provide insights on a possible 7700-year-old local food tradition.” Phys.org. 10/8/2024. https://phys.org/news/2024-10-tunisian-snail-insights-year-local.html Medievalists.net. “Vikings and Indigenous North Americans: New Walrus DNA Study Reveals Early Arctic Encounters.” https://www.medievalists.net/2024/10/vikings-and-indigenous-north-americans-new-walrus-dna-study-reveals-early-arctic-encounters/ Billing, Lotte. “Early interactions between Europeans and Indigenous North Americans revealed.” Lund University. Via EurekAlert. 9/28/2024. https://www.eurekalert.org/news-releases/1059638 Bliege Bird, R., Bird, D.W., Martine, C.T. et al. Seed dispersal by Martu peoples promotes the distribution of native plants in arid Australia. Nat Commun 15, 6019 (2024). https://doi.org/10.1038/s41467-024-50300-5 Tutella, Francisco. “Landscape effects of hunter-gatherer practices reshape idea of agriculture.” 10/10/2024. https://www.eurekalert.org/news-releases/1060928 aranto, S., Barcons, A.B., Portillo, M. et al. Unveiling the culinary tradition of ‘focaccia’ in Late Neolithic Mesopotamia by way of the integration of use-wear, phytolith & organic-residue analyses. Sci Rep 14, 26805 (2024). https://doi.org/10.1038/s41598-024-78019-9 Brinkhof, Tim. “People Were Making Focaccia Bread 9,000 Years Ago.” ArtNet. 12/15/2024. https://news.artnet.com/art-world/ancient-focaccia-recipe-study-2580239 Ward, Kim. “How MSU is bringing shipwrecked seeds back to life.” MSU Today. 11/6/2024. https://msutoday.msu.edu/news/2024/how-msu-is-bringing-shipwrecked-seeds-back-to-life Kuta, Sarah. “Seeds That Were Submerged in a Lake Huron Shipwreck for Nearly 150 Years.” Smithsonian. 11/25/2024. https://www.smithsonianmag.com/smart-news/scientists-are-trying-to-make-whiskey-using-rye-seeds-that-were-submerged-in-a-lake-huron-shipwreck-for-nearly-150-years-180985493/ Tutella, Francisco. “Peaches spread across North America through Indigenous networks.” Penn State. Via EurekAlert. 11/22/2024. https://www.eurekalert.org/news-releases/1065907 Irish Central Staff. “2000-year-old fig discovered by Irish archaeologists in Dublin.” Irish Central. 11/25/2024. https://www.irishcentral.com/news/archaeologists-fig-drumanagh-dublin Kieltyka, Matt. “Genetic study of native hazelnut challenges misconceptions about how ancient Indigenous peoples used the land.” EurekAlert. 12/5/2024. https://www.eurekalert.org/news-releases/1067317 Pflughoeft, Aspen. “2,800-year-old bakery — with tools and food remains — uncovered in Germany” Miami Herald. 11/29/2024. https://www.miamiherald.com/news/nation-world/world/article296316409.html#storylink=cpy Chinese Academy of Sciences. “Traces of 10,000-year-old ancient rice beer discovered in Neolithic site in Eastern China.” Phys.org. 12/9/2024. https://phys.org/news/2024-12-year-ancient-rice-beer-neolithic.html#google_vignette McHugh, Chris. “Medieval origins of Oxford college unearthed.” BBC. 12/15/2024. https://www.bbc.com/news/articles/cd0el584nrvo Morgan Library and Museum. “New Work by Frédéric Chopin Recently Discovered in the Collection of the Morgan Library and Museum.” https://host.themorgan.org/press/Morgan_Chopin_MediaRelease.pdf Henley, Jon. “Remains of man whose death was recorded in 1197 saga uncovered in Norway.” The Guardian. 10/27/2014. https://www.theguardian.com/world/2024/oct/27/remains-of-man-whose-death-was-recorded-in-1197-saga-uncovered-in-norway Babbs, Verity. “Archaeologists Unearth a 2,000-Year-Old Inscription Honoring an Ancient Wrestler.” ArtNet. 10/26/2024. https://news.artnet.com/art-world/archaeologists-unearth-a-2000-year-old-inscription-honoring-an-ancient-wrestler-2557032 Whiddington, Richard. Amateur Sleuth Uncovers Bram Stoker’s Lost Supernatural Tale—A Precursor to ‘Dracula’?” ArtNet. 11/22/2024. https://news.artnet.com/art-world/lost-bram-stoker-story-gibbet-hill-found-2557360 British Library. “An unknown leaf from the Poor Clares of Cologne.” Medieval Manuscripts Blog. https://blogs.bl.uk/digitisedmanuscripts/2024/12/poor-clares-of-cologne.html Thompson, Karen. “The Incas used stringy objects called 'khipus' to record data—we just got a step closer to understanding them.” Phys.org. 11/13/2024. https://phys.org/news/2024-11-incas-stringy-khipus-closer.html Whiddington, Richard. “An Archaeologist’s 150-Year-Old Message in a Bottle Is Uncovered by Norwegian Researchers.” ArtNet. 11/20/2024. https://news.artnet.com/art-world/archaeologists-150-year-old-message-uncovered-norwegian-lorange-2572859 Kuta, Sarah. “Read the 132-Year-Old Message in a Bottle Found Hidden Inside the Walls of a Scottish Lighthouse.” Smithsonian. 11/26/2024. https://www.smithsonianmag.com/smart-news/read-the-132-year-old-message-in-a-bottle-found-hidden-inside-the-walls-of-a-scottish-lighthouse-180985528/ Benzine, Vittoria. “Professor Translates 2,600-Year-Old Inscription That Linguists Claimed Could Never Be Read.” ArtNet. 11/20/2024. https://news.artnet.com/art-world/2600-year-old-inscription-decoded-2572494 Alberge, Dalya. “16th-century graffiti of Tower of London prisoners decoded for first time.” The Observer. 12/1/2024. https://www.theguardian.com/culture/2024/dec/01/16th-century-graffiti-of-tower-of-london-prisoners-decoded-for-first-time Oster, Sandee. “Ancient Iberian slate plaques may be genealogical records.” Phys.org. 12/3/2024. https://phys.org/news/2024-12-ancient-iberian-slate-plaques-genealogical.html Robbins, Hannah. “Oldest known alphabet unearthed in ancient Syrian city.” EurekAlert. 11/20/2024. https://www.eurekalert.org/news-releases/1065620 Göttingen University. “Press release: Skill and technique in Bronze Age spear combat.” 8/10/2024. https://www.uni-goettingen.de/en/3240.html?id=7562 Jackson, Justin. “'Getting high' in Paleolithic hunting: Elevated positions enhance javelin accuracy but reduce atlatl efficiency.” Phys.org. 10/16/2024. https://phys.org/news/2024-10-paleolithic-hunters-benefited-high.html#google_vignette Diamond, L.E., Langley, M.C., Cornish, B. et al. Aboriginal Australian weapons and human efficiency. Sci Rep 14, 25497 (2024). https://doi.org/10.1038/s41598-024-76317-w Langley, Michelle and Laura Diamond. “First-ever biomechanics study of Indigenous weapons shows what made them so deadly.” Phys.org. 10/28/2024. https://phys.org/news/2024-10-biomechanics-indigenous-weapons-deadly.html Babbs, Verity. “Rare Portrait of the Last Byzantine Emperor Unearthed in Stunning Greek Find.” ArtNet. 12/18/2024. https://news.artnet.com/art-world/byzantine-emperor-constantine-xi-fresco-greece-2589737 Nelson, George. “Archeologists Discover Hidden Tomb in Ancient City of Petra and a Skeleton Holding Vessel Resembling Indiana Jones’s ‘Holy Grail’.” 10/22/2024. https://www.artnews.com/art-news/news/petra-ancient-city-jordan-secret-hidden-tomb-archaeology-1234721828/ Osho-Williams, Olatunji. “Archaeologists in Petra Discover Secret Tomb Hiding Beneath a Mysterious Structure Featured in ‘Indiana Jones’.” Smithsonian. 10/15/2024. https://www.smithsonianmag.com/smart-news/archaeologists-in-petra-discover-secret-tomb-hiding-beneath-a-mysterious-structure-featured-in-indiana-jones-180985275/ Anderson, Sonja. “Archaeologists Say This Tiny Amulet Is the Oldest Evidence of Christianity Found North of the Alps.” Smithsonian. 12/19/2024. https://www.smithsonianmag.com/smart-news/archaeologists-say-this-tiny-amulet-is-the-oldest-evidence-of-christianity-found-north-of-the-alps-180985674/ UCL News. “Stonehenge may have been built to unify the people of ancient Britain.” 12/20/2024. https://www.ucl.ac.uk/news/2024/dec/stonehenge-may-have-been-built-unify-people-ancient-britain Casey, Michael. “Centuries-old angels uncovered at Boston church made famous by Paul Revere.” Associated Press. 12/24/2024. https://apnews.com/article/boston-old-church-angels-uncovered-paul-revere-4656e86d3f042b8ab8f7652a7301597c Benzine, Vittoria. “Thousands of Stolen Greek Artifacts Just Turned Up in an Athens Basement.” ArtNet. 12/19/2024. https://news.artnet.com/art-world/stolen-greek-artifacts-found-athens-basement-2589662 The History Blog. “Unique 500-year-old wooden shoe found in Netherlands cesspit.” 12/24/2024. https://www.thehistoryblog.com/archives/71988 Anderson, Sonja. “Archaeologists Discover Rare Clay Commander Among Thousands of Life-Size Terra-Cotta Soldiers in China.” Smithsonian. 12/31/2024. https://www.smithsonianmag.com/smart-news/archaeologists-discover-rare-clay-commander-among-thousands-of-life-size-terra-cotta-soldiers-in-china-180985747/ Gammelby, Peter F. “Water and gruel—not bread: Discovering the diet of early Neolithic farmers in Scandinavia.” Phys.org. 12/20/2024. https://phys.org/news/2024-12-gruel-bread-diet-early-neolithic.html#google_vignette See omnystudio.com/listener for privacy information.

This first installment the end of year 2024 edition of Unearthed! starts with updates, so many shipwrecks, and so much art. Research: Giuffrida, Angela. “Painting found by junk dealer in cellar is original Picasso, experts claim.” The Guardian. 10/1/2024. https://www.theguardian.com/artanddesign/2024/oct/01/painting-found-by-junk-dealer-in-cellar-is-original-picasso-experts-claim Lawson-Tancred, Jo. “‘Horrible’ Painting Found by a Junk Dealer Could Be a Picasso Worth $6 Million.” ArtNet. 10/1/2024. https://news.artnet.com/art-world/junk-dealer-picasso-2545786 Kuta, Sarah. “This Shipwreck’s Location Was a Mystery for 129 Years. Then, Two Men Found It Just Minutes Into a Three-Day Search.” Smithsonian. 9/30/2024. https://www.smithsonianmag.com/smart-news/this-shipwrecks-location-was-a-mystery-for-129-years-then-two-men-found-it-just-minutes-into-a-three-day-search-180985165/ Peru murals https://archaeology.org/news/2024/10/01/additional-moche-murals-uncovered-in-peru-at-panamarca/ Leung, Maple. “Team makes distilled wine in replica of bronze vessel found at emperor’s tomb.” MyNews. 12/13/2024. https://www.scmp.com/news/china/science/article/3290709/team-makes-distilled-wine-replica-bronze-vessel-found-emperors-tomb Feldman, Ella. “Dorothy’s Ruby Slippers From ‘The Wizard of Oz’ Sell for a Record-Breaking $28 Million.” Smithsonian. 12/10/2024. s-from-the-wizard-of-oz-sell-for-a-record-breaking-28-million-180985620/ Tamisiea, Jack. “Hairballs Shed Light on Man-Eating Lions’ Menu.” The New York Times. 10/11/2024. https://www.nytimes.com/2024/10/11/science/tsavo-lions-man-eating-dna.html Spears, Nancy Marie. “First-ever oral histories of Indian boarding school survivors, collected with care.” ICT. 10/16/2024. https://ictnews.org/news/first-ever-oral-histories-of-indian-boarding-school-survivors-collected-with-care Kuta, Sarah. “Biden Issues a ‘Long Overdue’ Formal Apology for Native American Boarding Schools.” Smithsonian. 10/25/2024. https://www.smithsonianmag.com/smart-news/biden-issues-a-long-overdue-biden-formally-apologizes-for-native-american-boarding-schools-180985341/ Schrader, Adam. “A New Monument Confronts the Dark Legacy of Native American Boarding Schools.” ArtNet. 12/13/2024. https://news.artnet.com/art-world/indian-boarding-school-national-monument-2586044 Boucher, Brian. “This Contemporary Artist Will Complete a Missing Scene in the Millennium-Old Bayeux Tapestry.” Artnet. 10/29/2024. https://news.artnet.com/art-world/helene-delprat-complete-bayeux-tapestry-2560937 Reuters. “Ancient Pompeii site uncovers tiny house with exquisite frescoes.” 10/24/2024. https://www.reuters.com/world/europe/ancient-pompeii-site-uncovers-tiny-house-with-exquisite-frescoes-2024-10-24/ The History Blog. “Tiny house frescoed like mansion in Pompeii.” 10/25/2024. http://www.thehistoryblog.com/archives/71444 Bowman, Emma. “New DNA evidence upends what we thought we knew about Pompeii victims.” NPR. 11/9/2024. https://www.npr.org/2024/11/08/g-s1-33553/pompeii-dna-evidence-vesuvius-victims Benzine, Vittoria. “Pompeii Experts Back Up Pliny’s Historical Account of Vesuvius Eruption.” ArtNet. 12/13/2024. https://news.artnet.com/art-world/pompeii-pliny-vesuvius-eruption-date-2587228 Willsher, Kim. “‘Bodies were dropped down quarry shafts’: secrets of millions buried in Paris catacombs come to light.” The Guardian. 10/19/2024. https://www.theguardian.com/world/2024/oct/19/bodies-quarry-shafts-millions-buried-paris-catacombs Kuta, Sarah. “See the Wreck of Ernest Shackleton’s ‘Endurance’ in Astonishing Detail With This New 3D Scan.” Smithsonian. 10/18/2024. https://www.smithsonianmag.com/smart-news/see-the-wreck-of-ernest-shackletons-endurance-in-astonishing-detail-with-this-new-3d-scan-180985274/ Boucher, Brian. “In a Rare Move, Boston’s Gardner Museum Snaps Up a Neighboring Apartment Building.” ArtNet. 10/18/2024. https://news.artnet.com/art-world/boston-gardner-museum-buys-apartment-building-2555811 Whipple, Tom. “Letters reveal the quiet genius of Ada Lovelace.” The Times. 6/14/2024. https://www.thetimes.com/uk/history/article/ada-lovelace-letters-shed-light-woman-science-1848-kdztdh9x0 Lawson-Tancred, Jo. “This 18th-Century Painting Could Rewrite Black History in Britain.” ArtNet. 10/14/2024. https://news.artnet.com/art-world/this-18th-century-painting-could-rewrite-black-history-in-britain-2552814 Factum Foundation. “William Blake’s Earliest Engravings.” 2024. https://factumfoundation.org/our-projects/digitisation/archiox-analysing-and-recording-cultural-heritage-in-oxford/william-blakes-earliest-engravings/ Whiddington, Richard. “William Blake’s Earliest Etchings Uncovered in Stunning High-Tech Scans.” ArtNet. 10/23/2024. https://news.artnet.com/art-world/william-blake-earliest-engravings-copper-plates-bodleian-2558053 Kinsella, Eileen. “X-Ray Analysis of Gauguin Painting Reveals Hidden Details… and a Dead Beetle.” ArtNet. 12/2/2024. https://news.artnet.com/art-world/gauguin-little-cat-analysis-van-gogh-museum-2577081 Oster, Sandee. “Archaeologists reveal musical instruments depicted in Zimbabwe's ancient rock art.” Phys.org. 11/29/2024. https://phys.org/news/2024-11-archaeologists-reveal-musical-instruments-depicted.html Niskanen, Niina. “Prehistoric hunter-gatherers heard the elks painted on rocks talking.” EurekAlert. 11/25/2024. https://www.eurekalert.org/news-releases/1065949 Metcalfe, Tom. “WWII British sub that sank with 64 on board finally found off Greek Island.” LiveScience. https://www.livescience.com/archaeology/wwii-british-sub-that-sank-with-64-on-board-finally-found-off-greek-island 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Amateur Sleuth Uncovers Bram Stoker’s Lost Supernatural Tale—A Precursor to ‘Dracula’?” ArtNet. 11/22/2024. https://news.artnet.com/art-world/lost-bram-stoker-story-gibbet-hill-found-2557360 British Library. “An unknown leaf from the Poor Clares of Cologne.” Medieval Manuscripts Blog. https://blogs.bl.uk/digitisedmanuscripts/2024/12/poor-clares-of-cologne.html Thompson, Karen. “The Incas used stringy objects called 'khipus' to record data—we just got a step closer to understanding them.” Phys.org. 11/13/2024. https://phys.org/news/2024-11-incas-stringy-khipus-closer.html Whiddington, Richard. “An Archaeologist’s 150-Year-Old Message in a Bottle Is Uncovered by Norwegian Researchers.” ArtNet. 11/20/2024. https://news.artnet.com/art-world/archaeologists-150-year-old-message-uncovered-norwegian-lorange-2572859 Kuta, Sarah. “Read the 132-Year-Old Message in a Bottle Found Hidden Inside the Walls of a Scottish Lighthouse.” Smithsonian. 11/26/2024. https://www.smithsonianmag.com/smart-news/read-the-132-year-old-message-in-a-bottle-found-hidden-inside-the-walls-of-a-scottish-lighthouse-180985528/ Benzine, Vittoria. “Professor Translates 2,600-Year-Old Inscription That Linguists Claimed Could Never Be Read.” ArtNet. 11/20/2024. https://news.artnet.com/art-world/2600-year-old-inscription-decoded-2572494 Alberge, Dalya. “16th-century graffiti of Tower of London prisoners decoded for first time.” The Observer. 12/1/2024. https://www.theguardian.com/culture/2024/dec/01/16th-century-graffiti-of-tower-of-london-prisoners-decoded-for-first-time Oster, Sandee. “Ancient Iberian slate plaques may be genealogical records.” Phys.org. 12/3/2024. https://phys.org/news/2024-12-ancient-iberian-slate-plaques-genealogical.html Robbins, Hannah. “Oldest known alphabet unearthed in ancient Syrian city.” EurekAlert. 11/20/2024. https://www.eurekalert.org/news-releases/1065620 Göttingen University. “Press release: Skill and technique in Bronze Age spear combat.” 8/10/2024. https://www.uni-goettingen.de/en/3240.html?id=7562 Jackson, Justin. “'Getting high' in Paleolithic hunting: Elevated positions enhance javelin accuracy but reduce atlatl efficiency.” Phys.org. 10/16/2024. https://phys.org/news/2024-10-paleolithic-hunters-benefited-high.html#google_vignette Diamond, L.E., Langley, M.C., Cornish, B. et al. 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Thomas Hahn discusses his paper on historical emissions and responsibility for them. Hahn, T., Morfeldt, J., Höglund, R. et al. Estimating countries' additional carbon accountability for closing the mitigation gap based on past and future emissions. Nat Commun 15, 9707 (2024). https://doi.org/10.1038/s41467-024-54039-x

In this episode of Discovery Matters we delve into groundbreaking advancements in Parkinson's disease research. Dodi and Conor transport us to the frontier of medical innovation, exploring the latest discoveries and techniques that hold promise for early diagnosis and treatment of Parkinson's disease. Show notes • Decet, Marianna et al. ‘A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism', Cell Reports Medicine, Volume 5, Issue 10. • Hällqvist, J., Bartl, M., Dakna, M. et al. ‘Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset'. Nat Commun 15, 4759 (2024). • Roald Dahl's Marvellous Children's Charity Keywords: non-invasive procedure, early diagnosis, synaptic homeostasis, Parkinsonism, biomarkers, machine learning, REM sleep disorder, inflammatory pathways, dopaminergic cells, predictive diagnostics, early intervention.

Substandard and falsified (SF) antimicrobials are a neglected global health problem and have been implicated as drivers of antimicrobial resistance (AMR). Substandard medicines are authorized medical products that fail to meet either their quality standards or their specifications, whereas falsified medicines are those that deliberately and fraudulently misrepresent their identity, composition or source. Host Angela Huttner is joined by Pernette Bourdillon Esteve, Technical Officer for the World Health Organization's Substandard/falsified Medical Products group, and Ben Cooper, epidemiologist at Oxford University and head of its Drug-Resistant Infection and Disease Dynamics (DRIaDD), to explore the effects of SF antimicrobials on people and AMR.This episode was edited by Kathryn Hostettler and peer-reviewed by Dr. Arjana Zerja of Mother Teresa University Hospital in Tirana, Albania. Literature Cavany S et al.  Nat Commun 14, 6153 (2023). doi: 10.1038/s41467-023-41542-w WHO Global Surveillance and Monitoring System for substandard and falsified medical products (2017). https://www.who.int/publications/i/item/9789241513425 

In episode 48 we discuss the association between semaglutide and alcohol use disorder.    Wang, W., Volkow, N.D., Berger, N.A. et al. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population. Nat Commun 15, 4548 (2024).    The Journal of Addiction Medicine: The Efficacy of GLP-1 Agonists in Treating Substance Use Disorder in Patients    We also discuss THC products that look like candy, a good podcast on targeted naltrexone, and perioperative opioids.  The LA Times: Surgeons give patients too many opioids. A few simple steps could curb excess prescribing  Reflector: The Sea Change   The New York Times: Consumption of Marijuana Edibles Surges Among Children, Study Finds  FTC: FTC and FDA Send Second Set of Cease-and-Desist Letters to Companies Selling Products Containing Delta-8 THC in Packaging Designed to Look Like Children's Snacks  ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---  This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.     The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.    Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  Twitter/X: @AddictionMedJC    YouTube: addictionmedicinejournalclub    Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

References Endocr Rev. 2020 Aug; 41(4): 594–609. Sci Signal. 2017 Jan 31; 10(464):eaaf7478. Nat Commun. 2022; 13: 6661 Acta Physiologia (OXFORD) 2024.  Volume240, Issue3March.e14111 Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8. --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Iaaaaaaaaago Jorge, Marcela Belleza e Nathalie Santana conversam sobre as últimas atualizações no tratamento da obesidade em três partes: o que é obesidade controlada? quais são as drogas novas? quais são os efeitos adversos? Use o cupom TDC2024 para assinar o HITT do Medcof e ganhe um cupom de 6 meses gratuitos do Guia TdC! https://hiit.grupomedcof.com.br Referências: 1. Chuang MH, Chen JY, Wang HY, Jiang ZH, Wu VC. Clinical Outcomes of Tirzepatide or GLP-1 Receptor Agonists in Individuals With Type 2 Diabetes. JAMA Netw Open. 2024;7(8):e2427258. Published 2024 Aug 1. doi:10.1001/jamanetworkopen.2024.27258 2. Coutinho W, Halpern B. Pharmacotherapy for obesity: moving towards efficacy improvement. Diabetol Metab Syndr. 2024;16(1):6. Published 2024 Jan 3. doi:10.1186/s13098-023-01233-4 3. Gudzune KA, Kushner RF. Medications for Obesity: A Review. JAMA. Published online July 22, 2024. doi:10.1001/jama.2024.10816 4. Halpern B, Mancini MC, de Melo ME, et al. Proposal of an obesity classification based on weight history: an official document by the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society for the Study of  5. Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038 6. Jastreboff AM, Kaplan LM, Frías JP, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. 2023;389(6):514-526. doi:10.1056/NEJMoa2301972 7. Li JR, Cao J, Wei J, Geng W. Case Report: Semaglutide-associated depression: a report of two cases. Front Psychiatry. 2023;14:1238353. Published 2023 Aug 29. doi:10.3389/fpsyt.2023.1238353 8. Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563 9. Obesity and Metabolic Syndrome (ABESO). Arch Endocrinol Metab. 2022;66(2):139-151. doi:10.20945/2359-3997000000465 10. Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. Published online July 8, 2024. doi:10.1001/jamainternmed.2024.2525 11. Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population [published correction appears in Nat Commun. 2024 Jun 18;15(1):5177. doi: 10.1038/s41467-024-49655-6]. Nat Commun. 2024;15(1):4548. Published 2024 May 28. doi:10.1038/s41467-024-48780-6 12. Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R. Association of semaglutide with risk of suicidal ideation in a real-world cohort. Nat Med. 2024;30(1):168-176. doi:10.1038/s41591-023-02672-2

Season 3 - Episode 5: "Can I Get Tested for Autism?"   Find more information, donate, and check out our merch! www.reallyweirdquestion.com You can find more history on Rebecca's newsletter, Carnal Knowledge, https://rebeccaldavisphdgmailcom.substack.com/ Her new book, Fierce Desires: A New History of Sex and Sexuality in America, is available for preorder! References:   Atherton G, Edisbury E, Piovesan A, Cross L. Autism Through the Ages: A Mixed Methods Approach to Understanding How Age and Age of Diagnosis Affect Quality of Life. J Autism Dev Disord. 2022 Aug;52(8):3639-3654. doi: 10.1007/s10803-021-05235-x. Epub 2021 Sep 4. PMID: 34482523; PMCID: PMC9296439.   Warrier V, Greenberg DM, Weir E, Buckingham C, Smith P, Lai MC, Allison C, Baron-Cohen S. Elevated rates of autism, other neurodevelopmental and psychiatric diagnoses, and autistic traits in transgender and gender-diverse individuals. Nat Commun. 2020 Aug 7;11(1):3959. doi: 10.1038/s41467-020-17794-1. PMID: 32770077; PMCID: PMC7415151.   https://www.autistichoya.com/2011/08/significance-of-semantics-person-first.html   https://neuroqueer.com/person-first-language-is-the-language-of-autistiphobic-bigots/   Gratton et al.  The Intersection of Autism and Transgender and Nonbinary Identities: Community and Academic Dialogue on Research and Advocacy.  AUTISM IN ADULTHOOD Volume 5, Number 2, 2023 Resources https://autisticadvocacy.org/ https://fireweedcollective.org/ https://rebirthgarments.com/#rebirthgarments

Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Webby Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Webby research laboratory H5N1 virus in dairy cattle and cats (Emerg Inf Dis) Emergence of H5N1 virus in dairy cattle (bioRxiv) Spillover potential of H9N2 bat virus (Nat Commun and TWiV 1111) Letters read on TWiV 1113 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Little Researcher (from Bioss) Alan – Global Polio Eradication Initiative's OPV switch was “unqualified failure.” Vincent – Errant Science Listener Picks Moragh – Paper Cuts Podcast Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this episode of Discovery Matters, hosts Dodi and Conor explore how synthetic biology can lead to transformative breakthroughs when it comes to dealing with global health problems. Through their conversation with Justin Vigar, a PhD student in Dr. Keith Pardee's lab at the University of Toronto in Canada, we learn how his paper-based diagnostic tool has the potential to provide faster, more cost-efficient, and accessible diagnostics for underserved locations. This is complemented by Amir Pandi and Tobi Erb's discussion of using AI and synthetic biology to develop new antimicrobial peptides. Show notes • U of T PhD student uses synthetic biology to create low-cost diagnostic tools. • Pandi, A., Adam, D., Zare, A. et al. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat Commun 14, 7197 (2023). https://doi.org/10.1038/s41467-023-42434-9 • Khalek IS, et al. Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. Sci Transl Med. 2024 Feb 21;16(735). https://doi.org/10.1126/scitranslmed.adk1867 • Josh A Goldstein, Jason Chao, Shelby Grossman, Alex Stamos, Michael Tomz, How persuasive is AI-generated propaganda?, PNAS Nexus, Volume 3, Issue 2, February 2024. https://doi.org/10.1093/pnasnexus/pgae034

References Dr Guerra-Graduate lipid biochemistry lectures Biochem J. 2022 Sep 30; 479(18): 1917–1940 Front Cell Dev Biol. 2022; 10: 946393. Nat Commun. 2019; 10: 97. Lennon-McCartney 1965. "Ive Just Seen a Face" https://youtu.be/m8LbJfC0SYM?si=gl_URu_yPTn9iZSd McShee, J./Traditional/Pentangle.1969 "Light Flight" https://youtu.be/2tyVezuUtCA?si=THxBJ0reUETkwDLa Mozart, WA. 1785.Piano Concerto No. 21 in C Major, K. 467 https://youtu.be/whTEVQ2OizI?si=YDMhOhlwmpKYqK-t --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this episode of the Epigenetics Podcast, we talked with Weiwei Dang from Baylor College of Medicine about his work on molecular mechanisms of aging and the role of H3K36me3 and cryptic transcription in cellular aging. The team in the Weiwei Dang lab explored the connection between histone marks, specifically H4K16 acetylation and H3K36 methylation, and aging. Dr. Dang describes how the lab conducted experiments by mutating H4K16 to determine its effect on lifespan. They observed that the mutation to glutamine accelerated the aging process and shortened lifespan, providing causal evidence for the relationship between H4K16 and lifespan. They also discovered that mutations in acetyltransferase and demethylase enzymes had opposite effects on lifespan, further supporting a causal relationship. Weiwei Dang then discusses their expanded research on aging, conducting high-throughput screens to identify other histone residues and mutants in yeast that regulate aging. They found that most mutations at K36 shortened lifespan, and so they decided to follow up on a site that is known to be methylated and play a role in gene function. They discovered that H3K36 methylation helps suppress cryptic transcription, which is transcription that initiates from within the gene rather than at the promoter. Mutants lacking K36 methylation showed an aging phenotype. They also found evidence of cryptic transcription in various datasets related to aging and senescence, including C. elegans and mammalian cells. References Dang, W., Steffen, K., Perry, R. et al. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459, 802–807 (2009). https://doi.org/10.1038/nature08085 Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., Wasko, B. M., Carr, D. T., He, C., Robison, B., Wagner, J., Gregory, B. D., Kaeberlein, M., Kennedy, B. K., Boeke, J. D., & Berger, S. L. (2015). H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes & development, 29(13), 1362–1376. https://doi.org/10.1101/gad.263707.115 Yu, R., Cao, X., Sun, L. et al. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nat Commun 12, 1981 (2021). https://doi.org/10.1038/s41467-021-22257-2 McCauley, B.S., Sun, L., Yu, R. et al. Altered chromatin states drive cryptic transcription in aging mammalian stem cells. Nat Aging 1, 684–697 (2021). https://doi.org/10.1038/s43587-021-00091-x   Related Episodes Epigenetic Mechanisms of Aging and Longevity (Shelley Berger) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine) Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Episode 59: In this episode, host Angie Gust talks about vitexin. Vitexin is an antioxidant found in a number of plants like buckwheat and mung beans. It has been touted as benefiting the brain and heart and helping maintain already-healthy blood sugar levels. Vitexin has multiple health benefits supporting wellness in a variety of different ways. Turning to the environment, there is good news on renewable energy. A 2023 article suggests that solar energy has reached a pivotal tipping point, ensuring its rapid and irreversible global proliferation. Key factors driving this shift include technological advancements, cost reductions, and significant investment increases in solar energy deployment, especially in India and China.  References Bhaduri, T. Reasons to be cheerful. Jan 5, 2024. Solar pumps are empowering women farmers in India. https://reasonstobecheerful.world/solar-based-irrigation-technology-women-farmers-india/ Biden-Harris Administration Advances SunZia Southwest Transmission Project. 5/18/23 https://www.doi.gov/pressreleases/biden-harris-administration-advances-sunzia-southwest-transmission-project Life Extension. 2021. What Are the Health Benefits of Vitexin? https://www.lifeextension.com/wellness/antioxidants/vitexin-health-benefits Nijsse, F.J., M.M., Mercure, JF., Ameli, N. et al. The momentum of the solar energy transition. Nat Commun 14, 6542 (2023). https://doi.org/10.1038/s41467-023-41971-7 Office of Energy Efficiency and Renewable Energy. Dec 14, 2023. Inflation Reduction Act spurs investment in domestic wind production. https://www.energy.gov/eere/articles/inflation-reduction-act-spurs-breakthrough-domestic-wind-production Sirur, S. Has solar energy been deployed to the point of no return? Some researchers think so. https://india.mongabay.com/2024/01/has-solar-energy-been-deployed-to-the-point-of-no-return-some-researchers-think-so/ US Government FACT SHEET: How the Inflation Reduction Act's Tax Incentives Are Ensuring All Americans Benefit from the Growth of the Clean Energy Economy. https://home.treasury.gov/news/press-releases/jy1830  

In this episode of the Epigenetics Podcast, we talked with Yali Dou from Keck School of Medicine of USC about her work on MLL Proteins in Mixed-Lineage Leukemia. To start off this Interview Yali describes her early work on MLL1 and its function in transcription, particularly its involvement in histone modification. She explains her successful purification of the MLL complex and the discovery of MOF as one of the proteins involved. Next, the interview focuses on her work in reconstituting the MLL core complex and the insights gained from this process. She shares her experience of reconstituting the MLL complex and discusses her focus on the crosstalk of H3K4 and H3K79 methylation, regulated by H2BK34 ubiquitination. The podcast then delves into the therapeutic potential of MLL1, leading to the discovery of a small molecule inhibitor. Finally, we talk about the importance of the protein WDR5 in the assembly of MLL complexes and how targeting the WDR5-ML interaction can inhibit MLL activity.   References Dou, Y., Milne, T., Ruthenburg, A. et al. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13, 713–719 (2006). https://doi.org/10.1038/nsmb1128 Wu, L., Zee, B. M., Wang, Y., Garcia, B. A., & Dou, Y. (2011). The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation. Molecular Cell, 43(1), 132–144. https://doi.org/10.1016/j.molcel.2011.05.015 Cao, F., Townsend, E. C., Karatas, H., Xu, J., Li, L., Lee, S., Liu, L., Chen, Y., Ouillette, P., Zhu, J., Hess, J. L., Atadja, P., Lei, M., Qin, Z. S., Malek, S., Wang, S., & Dou, Y. (2014). Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia. Molecular Cell, 53(2), 247–261. https://doi.org/10.1016/j.molcel.2013.12.001 Park, S.H., Ayoub, A., Lee, YT. et al. Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun 10, 5540 (2019). https://doi.org/10.1038/s41467-019-13550-2   Related Episodes Dosage Compensation in Drosophila (Asifa Akhtar) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

References Nat Commun. 2022; 13: 4435. Nat Commun 2020; 11: 35 Hayward, J. 1971. "You Can Never Go Home" Moody Blues. https://youtu.be/mUhboF8d1x0?si=IX4iP_W0f3uR65qo Jagger, Richards, Oldham. 1964. "As Tears Go By". Marianne Faithful. https://youtu.be/S8EykQaZ8CU?si=X42TiNsveR7rwdHB --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Gloria Reithmaier talks to @geoengineering1 about coastal blue carbon, work/life balance, and being a mum in academia. Paper: Reithmaier, G.M.S., Cabral, A., Akhand, A. et al. Carbonate chemistry and carbon sequestration driven by inorganic carbon outwelling from mangroves and saltmarshes. Nat Commun 14, 8196 (2023). https://doi.org/10.1038/s41467-023-44037-w

總是覺得早上醒不來嗎？ 研究指出，除了基因影響，「吃早餐」決定大腦的清醒程度！ 還有哪些影響大腦清醒的因素，又該如何破解呢？ 這集讓凱熙從研究文獻的角度講給你聽！

In a recent discussion with CancerNetwork®, Joleen Hubbard, MD, research collaborator with Mayo Clinic and deputy director for clinical research at Allina Health Cancer Institute in Minneapolis, Minnesota, discussed new opportunities for patients with colorectal cancer (CRC).   In the discussion, Hubbard highlighted the potential of trastuzumab deruxtecan-nxki (Enhertu; T-DXd) in patients with HER2-expressing metastatic CRC based on studies including the phase 2 DESTINY-CRC01 trial (NCT03384940), which assessed the efficacy and safety of the agent in those who progressed after 2 or more prior regimens.1  These trials may play a role in continuing HER2 inhibition downstream after the FDA approval of trastuzumab (Herceptin) plus tucatinib (Tukysa) in patients with metastatic HER2-positive CRC.2   Hubbard also discussed the phase 3 MOUNTAINEER-03 study (NCT03043313) and its effects in the CRC space.3 This trial assessed the safety and efficacy of frontline tucatinib and trastuzumab in patients with treatment-refractory, RAS wild-type, HER2-positive metastatic CRC. Primary endpoints for this analysis showed a clinically meaningful overall response rate of 38.1% and a median duration of response of 12.4 months. Additionally, the treatment combination was well tolerated.   She said she is “optimistic” that moving HER2-directed therapy to the first-line setting, as seen in the MOUNTAINEER-03 study, may help outcomes for patients with metastatic CRC.  “It's a very exciting space,” Hubbard said. “Because it's only 5% to 8% of patients [who have CRC], it may not get as much attention, but there's 150,000 new cases of [CRC] diagnosed each year. So, 5% to 8% of that is a large number of patients [whom] we need to be looking at, studying, and potentially impact with these treatments.”  References  Yoshino T, Di Bartolomeo M, Raghav K, et al. Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer. Nat Commun. 2023;14(1):1-13. doi:10.1038/s41467-023-38032-4   Seagen announces FDA accelerated approval of Tukysa (tucatinib) in combination with trastuzumab for people with previously treated RAS wild-type, HER2-positive metastatic colorectal cancer. News release. FDA. January 19, 2023. Accessed December 6, 2023. https://bwnews.pr/3Xpzbqn  Bekaii-Saab TS, Van Cutsem E, Tabernero J, et al. MOUNTAINEER-03: phase 3 study of tucatinib, trastuzumab, and mFOLFOX6 as first-line treatment in HER2+ metastatic colorectal cancer—Trial in progress. J Clin Oncol. Published online January 24, 2023. doi:10.1200/jco.2023.41.4_suppl.tps261 

Welcome BACK to the Balanced Bodies Blueprint! In this episode, hosts Vinny Russo and Dr. Eryn Stansfield dismantle diet dogma. Unravel misconceptions about fats, carbs, and calories, and gain insights into a holistic approach to nutrition. Insights: *Carbs and Fats Unveiled: Understand the truth about dietary fats and carbs – they're not the enemy, and challenge the belief that carbs hinder weight loss. *Low-Carb Reality: Explore the consequences of extreme low-carb diets. Carbs are crucial for energy. *Genetic Weight Loss: Dive into a study on weight loss in high-carb and high-fat diets based on individual genotypes. *Calorie Hierarchy: Vinny emphasizes the hierarchy of nutrition, focusing on calorie intake, protein, and exercise. *Calorie Calculators Exposed: Generic calculators don't consider individual goals. Vinny recommends personalized approaches. *AI in Nutrition: While AI can assist, the human touch is irreplaceable in coaching. *Glycemic Index vs. Load: Vinny favors glycemic load for a comprehensive understanding of carbs' impact on blood sugar. Tune in for a paradigm shift in your health journey. Leave a 5-star review, share on social media, and join the conversation! If You're Ready to take the next step? Sign up to work with Balanced Bodies for individual coaching and support. Your health and fitness goals are within reach. Have questions or feedback? Leave a comment, visit our website, or connect with us on social media. We'd love to hear from you. Coach VinnyEmail: vinny@balancedbodies.ioInstagram: vinnyrusso_balancedbodiesFacebook: Vinny Russo Dr. ErynEmail: dr.eryn@balancedbodies.ioInstagram: dr.eryn_balancedbodiesFacebook: Eryn Stansfield LEGION 20% OFF CODEGo to https://legionathletics.com/ and use the code RUSSO for 20% off your order! Sources Mentioned in this Episode: Höchsmann, C., Yang, S., Ordovás, J.M. et al. The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial. Nat Commun 14, 6321 (2023). https://doi.org/10.1038/s41467-023-41969-1

This episode: A marine protist predator traps prey microbes in an attractive bubble of mucus, eats what it wants, and lets the rest sink, possibly sequestering significant amounts of carbon! Download Episode (7.8 MB, 11.4 minutes) Show notes: Microbe of the episode: Bat associated cyclovirus 1 News item Takeaways The oceans have a lot of unique, unexplored life in them. This is true on a macro level but even more on a microscopic level, with many different kinds of microbes of various groups with fascinating life strategies. And despite being microscopic, with enough of them around, they can affect the whole planet's climate in significant ways. In this study, one protist species gets most of its nutrients from photosynthesis, but what it can't get from the sun, it takes from prey microbes by force. To catch its prey, it creates an intricate bubble of mucus called a mucosphere, and waits for other microbes to swim into it, thinking it is food, and get stuck. Then the predator chooses the prey cell it wants and abandons the rest, letting them sink to the ocean floor and locking away the carbon they contain in the process.   Journal Paper: Larsson ME, Bramucci AR, Collins S, Hallegraeff G, Kahlke T, Raina J-B, Seymour JR, Doblin MA. 2022. Mucospheres produced by a mixotrophic protist impact ocean carbon cycling. Nat Commun 13:1301. Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

  Hey there, welcome back to the Empowered Nutrition Podcast. I'm Erin Skinner, your host, and I'm excited to take you on a journey into the incredible world of Berberine in this episode. Together, we'll discover the superpowers of this natural plant compound and its profound impact on our digestive, metabolic, and hormonal health. Berberine: The Unsung Hero Imagine Berberine as the unsung hero of the supplement world. It's not a prescription drug, but it's gaining superstar status for its unique ability to kickstart the release of glucagon-like peptide-1 (GLP-1). These GLP-1 superpowers are a game-changer in the realm of metabolic health. Safety First: Navigating the Berberine Universe Let's navigate the safety of Berberine. Most adults can embrace its benefits, but we need to be cautious. Expect some minor side effects like mild abdominal discomfort, constipation, or the occasional bout of nausea. But a word of advice, Berberine is best suited for those facing health challenges. For healthy individuals, it may not be the supplement you're looking for. Witness Berberine's Breathtaking Feats Prepare to be wowed by Berberine's breathtaking feats. It swoops in to save the day in the battle against diabetes, polycystic ovary syndrome (PCOS), high cholesterol, and the formidable obesity villain. It's a powerful ally, but having healthcare professionals as your sidekicks when introducing Berberine to your health journey is a smart move. Dosing Drama and Cautious Calm Let's dive into the dosing drama. The script reads 500 milligrams, two to three times a day, for one to six months. Berberine may be a powerful ally, but long-term alliances should be approached with caution. Especially if your medication squad is already on standby. Berberine's Secret Weapons Discover Berberine's secret weapons as I unravel the six primary mechanisms through which it conquers the battlefield. From rallying nitrate-reducing bacteria to amping up short-chain fatty acid production, this hero doesn't back down. It's all part of the grand plan to reduce inflammation, optimize bile metabolism, foster Akkermansia bacteria growth, and control hormones to slay the dragons of appetite and sugar cravings. Calling All Health Warriors Berberine steps into the spotlight when health warriors face particular adversaries. When weight loss resistance, metabolic syndrome, insulin resistance, type 2 diabetes, and PCOS are the battlegrounds, Berberine is your trusty sword. For other quests, consult your healthcare professionals for guidance. Enduring Legacy The awe-inspiring aspect of Berberine? Its enduring legacy. Even after Berberine exits the stage, its impact on the gut microbiome continues to shine. It's like having a guardian angel looking out for your health, long after the final bow. The Final Act As we wrap up this episode, I hope you've gained a newfound appreciation for the superpowers of Berberine. This superhero in supplement form may be your ticket to a healthier, happier future. References used in this podcast episode: 1.The Natural Medicine's Database: Berberine (Professional Monograph) https://info.trchealthcare.com/natmed-ppc 2.Zhang Y, Gu Y, Ren H, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020;11(1):5015. 3.Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020;155:104722. 4.Zhang L, Wu X, Yang R, et al. Effects of Berberine on the Gastrointestinal Microbiota. Front Cell Infect Microbiol. 2020;10:588517. 5.Och A, Och M, Nowak R, Podgorska D, Podgorski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022;27(4). 6.Cao RY, Zheng Y, Zhang Y, et al. Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action. Am J Chin Med. 2021;49(7):1645-1666. 7.Wang H, Zhang H, Gao Z, Zhang Q, Gu C. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol. 2022;12:854885. 8.Li J, Meng P, Zhang J, He M. Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson's Disease Patients. Contrast Media Mol Imaging. 2022;2022:8381870. 9.Ming J, Yu X, Xu X, et al. Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. Genome Med. 2021;13(1):125. Ready to dive in? Listen here! Love it? Hate it? We'd love to hear your feedback!     Interested in our Lean for Life Membership? Heal your Metabolism with the Lean for Life app: https://empowered-nutrition.ck.page/193bb2cd67 Help yourself feel aligned using our three phase approach: Lean for Life Membership called Heal, Optimize , and Refinewhere you will be empowered to reverse previous metabolic damage with the assistance of our team of Registered Dietitian Nutritionists. Check out more details on our website!   Want to learn more about our one-on-one Empowered Nutrition coaching? Book a free chemistry call to discuss your story and see if we're a good fit. Enjoying the podcast? Please review the Empowered Nutrition Podcast on Apple Podcasts or wherever you listen! Then, send me a screenshot of your positive review to podcast@empowerednutrition.health as a DM on Instagram (@empowerednutrition.health).Include a brief description of what you're working on with your health and/or nutrition and I'll send you a free custom meal plan! Do you have questions you would like answered on the Empowered Nutrition podcast? You can propose your questions/ideas by email to: podcast@empowerednutrition.health Follow us on: Instagram | Facebook

Join us for part 2 of our discussion with neurologist Dr. Erik Ensrud as we continue to discuss neurodegenerative disorders and explore the factors that WE can control that may decrease our risk or modify our course if we are indeed diagnosed. Please, join our community https://members.lastingimpactwellness.com/podcast-newsletter-signup As always, questions, comments & topic suggestions welcome at info@lastingimpactwellness.com Follow us on Instagram & Facebook @lastingimpactwellness Please be sure to subscribe, leave us a review & SHARE this podcast with others! We truly appreciate your support. Original music by EP3 Episode references: Alzheimer's Association Parkinson's Foundation Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, Gach HM, Thompson PM, Ho AJ, Kuller LH. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010 Oct 19;75(16):1415-22. https://health.ucdavis.edu/news/headlines/volunteering-in-late-life-may-protect-the-brain-against-cognitive-decline-and-dementia/2023/07#:~:text=(Sacramento)%20Volunteering%20in%20late%20life,International%20Conference%202023%20in%20Amsterdam. Day SM, Gironda SC, Clarke CW, Snipes JA, Nicol NI, Kamran H, Vaughan W, Weiner JL, Macauley SL. Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice. Neurobiol Dis. 2023 Feb;177:105967. Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, Kivimäki M, Dugravot A, Singh-Manoux A. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021 Apr 20;12(1):2289. Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

Welcome to the Olink® Proteomics in Proximity podcast!  Below are some useful resources from this episode:  Published study of primary focusÁlvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerberg L, Uhlén M. Next generation pan-cancer blood proteome profiling using proximity extension assay. Nat Commun. 2023 Jul 18;14(1):4308. doi: 10.1038/s41467-023-39765-y. PMID: 37463882; PMCID: PMC10354027. https://pubmed.ncbi.nlm.nih.gov/37463882/  Laboratory, first author, and corresponding author of the study·         SciLifeLab, a collaborative resource for life scientists located in Sweden: https://www.scilifelab.se/·         María Bueno Álvez (first author), PhD student, Science for Life Laboratory (SciLifeLab): https://www.linkedin.com/in/mar%C3%ADa-bueno-%C3%A1lvez-33395b192/ ·         Dr. Mathias Uhlén (corresponding author), Professor of Microbiology, Royal Institute of Technology (KTH), Leader of the Human Protein Atlas, Founding director of the Science for Life Laboratory (SciLifeLab): https://www.kth.se/pro/sysbio/uhlen-group/researchers/mathias-uhlen-1.67763  Olink tools and software·         Olink® Explore 1536, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: https://olink.com/products-services/explore/·         Olink® Explore HT, Olink's newest solution for high-throughput biomarker discovery that measures 5300+ proteins simultaneously with minimal sample consumption: https://olink.com/products-services/exploreht/ ·         Olink® Insight, an open-access resource to accelerate protein biomarker discovery: https://insight.olink.com/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world's largest scientific studies of blood protein biomarkers conducted to date·         Published article: Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. 2023 Apr;75(4):544-552. doi: 10.1002/art.42376. Epub 2022 Dec 28. PMID: 36239377. https://pubmed.ncbi.nlm.nih.gov/36239377/ ·         UKB-PPP website: https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies  Analysis of UK Biobank proteomics data from cancer patients, with co-authors including Ruth C. Travis, Karl Smith-Byrne, and Joshua R. AtkinsPreprint article: Papier K, Atkins JR, Tong TYN, Gaitskell K, Desai T, Ogamba CF, Parsaeian M, Reeves GK, Mills IG, Key TJ, Smith-Byrne K, Travis RC. Identifying proteomic risk factors for cancer using prospective and exome analyses: 1,463 circulating proteins and risk of 19 cancers in the UK Biobank. medRxiv 2023.07.28.23293330; doi: https://doi.org/10.1101/2023.07.28.23293330. https://www.medrxiv.org/content/10.1101/2023.07.28.23293330v1 U-CAN Biobank, a prospective biobank of cancer patient biomaterial in SwedenGlimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T. U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta Oncol. 2018 Feb;57(2):187-194. doi: 10.1080/0284186X.2017.1337926. Epub 2017 Jun 20. PMID: 28631533. https://pubmed.ncbi.nlm.nih.gov/28631533/  Galleri GRAIL test, a blood-based test that detects a biosignature shared by over 50 cancer types: https://grail.com/galleri-test/  Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: https://www.gtexportal.org/home/ Human Protein Atlas (HPA), a Swedish-based program with the aim to map all human proteins using an integration of various omics technologies and provide these data freely available to the scientific community: https://www.proteinatlas.org/   Would you like to subscribe to the podcast on your favorite player or app? You can do so here:  Apple Podcasts: https://apple.co/3T0YbSm  Spotify Podcasts: https://open.spotify.com/show/2sZ2wxO...  Google Podcasts: https://podcasts.google.com/feed/aHR0...  Amazon Music: https://music.amazon.com/podcasts/d97...  Podcast Addict: https://podcastaddict.com/podcast/409...  Deezer: https://www.deezer.com/show/5178787  Player FM: https://player.fm/series/series-3396598   In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY  For any questions regarding information Olink Proteomics, please email us at info@olink.com or visit our website: https://www.olink.com/ WHAT IS PROTEOMICS IN PROXIMITY?Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.

Progressive decline in our brains and nervous system, more than other types of disease, truly challenges who we are as individual people. Neurodegenerative disorders such as Alzheimers, Parkinson's, Multiple Sclerosis and others are among the most feared possibilities we face. Join us for a two part discussion with neurologist Dr. Erik Ensrud to learn about the range of these diseases that affect millions of people. But more than a review, the message is that now, more than ever, we can do something about changing our risk of ever getting these diseases or the rate of progression if we do. As always, questions, comments & topic suggestions welcome at info@lastingimpactwellness.com Follow us on Instagram & Facebook @lastingimpactwellness Please be sure to subscribe, leave us a review & SHARE this podcast with others! We truly appreciate your support. Original music by EP3 Episode references: Alzheimer's Association Parkinson's Foundation Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, Gach HM, Thompson PM, Ho AJ, Kuller LH. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010 Oct 19;75(16):1415-22. https://health.ucdavis.edu/news/headlines/volunteering-in-late-life-may-protect-the-brain-against-cognitive-decline-and-dementia/2023/07#:~:text=(Sacramento)%20Volunteering%20in%20late%20life,International%20Conference%202023%20in%20Amsterdam. Day SM, Gironda SC, Clarke CW, Snipes JA, Nicol NI, Kamran H, Vaughan W, Weiner JL, Macauley SL. Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice. Neurobiol Dis. 2023 Feb;177:105967. Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, Kivimäki M, Dugravot A, Singh-Manoux A. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021 Apr 20;12(1):2289. Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

Let's explore the world of organoids and their potential to revolutionize disease treatment. Joined by Matthias Zilbauer and Roisin Owens, we look at the interplay of the gut-brain axis with organic electronic materials. Dive into the advances in organoid and microbial models used to develop treatments for illnesses such as Irritable Bowel Syndrome (IBS), Crohn's Disease, and Ulcerative Colitis. Join Dodi and Conor to discover how bioengineering could change our understanding of health and disease - and our lives. Show notes Shi, F., Evans, J. Surprising combinations of research contents and contexts are related to impact and emerge with scientific outsiders from distant disciplines. Nat Commun 14, 1641 (2023). https://doi.org/10.1038/s41467-023-36741-4. Moon landing: India's home-grown tech cut the costs (nature.com) Keywords: microbiome, patient, model, cells, tissue, disease, gut, biological systems, microbes, biology, pediatric gastroenterology, science, organoids

Eigentlich regnet es viel mehr als früher, sagt die Forschung. Doch das macht uns noch lange nicht immun gegen Dürre, wie wir nicht nur im Süden Europas sehen. Die Trockenheit nimmt zu, Landwirtschaft und Kommunen reagieren. Dürre, Starkregen, Klimawandel - alles hängt mit allem zusammen, sagt Wissenschaftsjournalistin Nele Rößler. Sie hat sich in der Landwirtschaft umgesehen ebenso wie im Wasserwerk und auf einem Regenwasserweg und mit zahlreichen Forschenden gesprochen. Mit Host Lucie Kluth spricht sie über ihre Beobachtungen, darüber, wie Regen entstehen kann zum Beispiel, - und immer wieder flankiert Datenjournalistin Isabel Lerch oder erhebt Einspruch: Sie berichtet von ausführlichen Abfragen in deutschen Landkreisen und kreisfreien Städten zum Thema Klimafolgenanpassung - wie schätzen die Umfrageteilnehmer die Gefahr durch Dürre ein und was tun sie dagegen? Wie hat sich der Zustand der Böden in den vergangenen Jahrzehnten verändert? DIE HINTERGRUNDINFORMATIONEN: 1. Wasserstrategie der Bundesregierung: Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz (Herausgeber). Nationale Wasserstrategie, 15. März 2023 https://www.bmuv.de/fileadmin/Daten_BMU/Download_PDF/Binnengewaesser/BMUV_Wasserstrategie_bf.pdf 2. Sinkende Grundwasserspiegel in Deutschland: Wunsch, A., Liesch, T. & Broda, S. Deep learning shows declining groundwater levels in Germany until 2100 due to climate change. Nat Commun 13, 1221 (2022). https://doi.org/10.1038/s41467-022-28770-2 3. Mehr Niederschlag und Starkregen durch Erderwärmung: Lehmann, J., Coumou, D. & Frieler, K. Increased record-breaking precipitation events under global warming. Climatic Change 132, 501–515 (2015). https://doi.org/10.1007/s10584-015-1434-y 4. Definitionen unterschiedlicher Dürreformen: Deutscher Wetterdienst. Dürre. Lexikon. https://www.dwd.de/DE/service/lexikon/Functions/glossar.html?lv2=100578&lv3=603288 [aufgerufen am 1. August 2023] 5. Desertifikation auf dem afrikanischen Kontinent: Silja Fröhlich. Wie steht es um Afrikas grüne Mauer?. Deutsche Welle; 31. März 2023. https://www.dw.com/de/die-gro%C3%9Fe-gr%C3%BCne-mauer-wie-steht-es-um-afrikas-vorzeigeprojekt/a-52970906 6. Entstehung von Grundwasser: Grundwasser. Hessisches Landesamt für Naturschutz, Umwelt und Geologie. https://www.hlnug.de/dossiers/duerre/grundwasser. [aufgerufen am 1. August 2023] 7. Messung von Bodenfeuchte: Bodenfeuchte. Landesamt für Umweltschutz Sachsen-Anhalt. https://lau.sachsen-anhalt.de/analytik-service/indikatoren-nachhaltigkeit/klimafolgen-indikatoren-fuer-sachsen-anhalt/bodenfeuchte#:~:text=Generell%20gilt%20aber%2C%20dass%20Bodenfeuchtewerte,die%20Pflanzen%20reduzieren%20ihre%20Leistungen. [aufgerufen 1. August 2023] 8. Hydrologische Dürre und ihre Folgen: Gabriele Wernecke, Anna-Dorothea Ebner von Eschenbach, Yvonne Strunck,, Lothar Kirschbauer, André Müller (Herausgeber). Wasserressourcen - Wissen in Flussgebieten vernetzen. Koblenz; 2016 März S. 131. https://www.bafg.de/DE/05_Wissen/02_Veranst/2016/2016_03_17_programm.pdf?__blob=publicationFile 9. Kosten für Trinkwasser in Deutschland: Trinkwasser-wissen. https://www.trinkwasser-wissen.net/service/faq/kosten-leistungswasser#:~:text=1%20Liter%20Leitungswasser%20kostet%20in,2%20bis%205%20Flaschen%20Mineralwasser [aufgerufen am 18. August 2023] 9. Recherche und deutschlandweite Umfrage zur Anpassung an die Folgen des Klimawandels: Behrend, A., Lerch, I. & Hörz, M. Klimawandel: Dürre trifft Norddeutschland besonders stark. https://www.ndr.de/nachrichten/info/Klimawandel-Duerre-trifft-Norddeutschland-besonders-stark,klimafolgen106.html 10. CORRECTIV-Recherche zum sinkenden Grundwasserspiegel in Deutschland: Joeres, A., Steger, G., Huth, K., Donheiser, M. & Wörpel, S. Wo in Deutschland das Grundwasser sinkt. CORRECTIV; https://correctiv.org/aktuelles/kampf-um-wasser/2022/10/25/klimawandel-grundwasser-in-deutschland-sinkt/ [aufgerufen am 12. September 2023] 11. Dürre-Definition für Klimafolgen-Recherche: Marx, A. Dürremonitor Deutschland. https://www.ufz.de/index.php?de=37937 [aufgerufen am 12. September 2023] 12. Wasserentnahme-Fälle in Deutschland: Diemand, S. & Finsterbusch, S. Kampf ums Wasser. Frankfurter Allgemeine Zeitung; 7. August 2022. https://www.faz.net/aktuell/wirtschaft/unternehmen/deutschland-der-kampf-ums-wasser-hat-mancherorts-laengst-begonnen-18224988.html [aufgerufen am 12. September 2023] 13. CORRECTIV-Recherche zum Wasserverbrauch der Landwirtschaft: Joeres, A., Steger, G., Huth, K. & Bogdanski, D. Wassermangel: Konsum der Landwirtschaft offenbar massiv unterschätzt. CORRECTIV; 2. Februar 2023. https://correctiv.org/aktuelles/klimawandel/2023/02/02/wasser-konsum-der-landwirtschaft-unterschaetzt/#:~:text=In%20Deutschland%20kommt%20die%20Landwirtschaft,sogar%20weit%20unter%20zwei%20Prozent. [aufgerufen am 12. September 2023] 14. Wasserverbrauch in Deutschland: Umweltbundesamt. Wasserressourcen und ihre Nutzung. https://www.umweltbundesamt.de/daten/wasser/wasserressourcen-ihre-nutzung#wassernachfrage. [aufgerufen am 12. September 2023] 15. Beispiel Lausitzer Seenland: Informationen des Zweckverbandes Lausitzer Seenland Brandenburg. https://www.zweckverband-lsb.de/visioncontent/mediendatenbank/seejournal_ausgabe_november_2012.pdf. [aufgerufen am 12. September 2023] 16. Dürreresistente Bäume: Artelt, J. Diese 7 Bäume sind besonders widerstandsfähig gegen Hitze, Dürre und Stürme; 5. September 2021. https://utopia.de/ratgeber/diese-7-baeume-sind-besonders-widerstandsfaehig-gegen-hitze-duerre-und-stuerme/. [aufgerufen am 12. September 2023]

Explore the transformative role of Artificial Intelligence (AI) in the fight against COVID-19 and beyond in this episode of "The AI Frontier". We delve into how AI has been instrumental in early virus detection, diagnosis, predicting COVID-19 hotspots, and even accelerating vaccine development. But it's not just about the technological advancements; we also navigate the ethical maze that these AI applications present, from privacy concerns with contact tracing apps to the implications of AI-driven decision making in healthcare. As we look towards a post-COVID world, we discuss the lasting impact of these AI innovations and their potential role in future pandemic preparedness. Join us as we dissect AI's role in pandemic mitigation and the ethical challenges ahead. -------------------------------References used in this episode:1.    Czabanowska K, Kuhlmann E. Public health competences through the lens of the COVID‐19 pandemic: what matters for health workforce preparedness for global health emergencies. Int J Health Plann Mgmt. 2021 May;36(S1):14-9. [Link]2.    Rehman IU, Sobnath D, Nasralla MM, Winnett M, Anwar A, Asif W, et al. Features of Mobile Apps for People with Autism in a Post COVID-19 Scenario: Current Status and Recommendations for Apps Using AI. Diagnostics. 2021 Oct 17;11(10):1923 [Link]3.    Jin C, Chen W, Cao Y, Xu Z, Tan Z, Zhang X, et al. Development and evaluation of an artificial intelligence system for COVID-19 diagnosis. Nat Commun. 2020 Oct 9;11(1). [Link]4.    Kaushik AK, Dhau JS, Gohel H, Mishra YK, Kateb B, Kim N, et al. Electrochemical SARS-CoV-2 Sensing at Point-of-Care and Artificial Intelligence for Intelligent COVID-19 Management. ACS Appl Bio Mater. 2020 Nov 16;3(11):7306-25. [Link]5.    Vinay R, Baumann H, Biller-Andorno N. Ethics of ICU triage during COVID-19. British Medical Bulletin. 2021 Jun 10;138(1):5-15. [Link]6.    Anshari M, Hamdan M, Ahmad N, Ali E, Haidi H. COVID-19, artificial intelligence, ethical challenges and policy implications. AI & Soc. 2023 Apr;38(2):707-20. [Link]Support the Show.Keep AI insights flowing – become a supporter of the show!Click the link for details

Prof. Dr. Destenie Nock joins Dr. Ahlmahz Negash and Paul Dockery for a conversation about what the grid of the future *should* look like. The discussion dives deep into (1) the energy equity gap, (2) a methodology for finding the optimal expansion of a power system under the objective of maximizing social benefit, (3) the Gini coefficient, and (4) how to use the Strategic Objective Hierarchy combined with the expertise of social scientists to translate community input into rigorously measurable inputs into an optimization model!You can find the podcast on Apple Podcast, Spotify, or wherever you get your podcasts. Share with friends that are electric utility enthusiasts, like us!09:24 - A benefit maximization approach to utility planningDestenie Nock, Todd Levin, Erin Baker, Changing the policy paradigm: A benefit maximization approach to electricity planning in developing countries, Applied Energy, Volume 264, 2020, 114583, ISSN 0306-2619, https://doi.org/10.1016/j.apenergy.2020.114583.28:13 - Amplifying community leader perspectivesErin Baker, Destenie Nock, Todd Levin, Samuel A. Atarah, Anthony Afful-Dadzie, David Dodoo-Arhin, Léonce Ndikumana, Ekundayo Shittu, Edwin Muchapondwa, Charles Van-Hein Sackey, Who is marginalized in energy justice? Amplifying community leader perspectives of energy transitions in Ghana, Energy Research & Social Science, Volume 73, 2021, 101933, ISSN 2214-6296, https://doi.org/10.1016/j.erss.2021.101933.Prof. Dr. Destenie Nock explainer videos: https://www.youtube.com/@dr.destenienock4164/videos48:53 - Unveiling hidden energy poverty using the energy equity gapCong, S., Nock, D., Qiu, Y.L. et al. Unveiling hidden energy poverty using the energy equity gap. Nat Commun 13, 2456 (2022). https://doi.org/10.1038/s41467-022-30146-5 Video link to “The Energy Equity Gap: Unveiling Hidden Energy Poverty” presentation for Energy Seminar Series at UC Davis Video link to Destenie Nock: Identifying Hidden Forms of Energy Poverty Video link to Energy Nerd Show NOAA's Meteorological Development Lab's work on Wet Bulb Globe Temperatures NOAA's experimental tools for calculating Wet Bulb Globe Temperatures and how it compares to heat index Evaluating the 35°C wet-bulb temperature adaptability threshold for young healthy subjects 1:07:38 - What should the grid of the future look like?1:12:42 - Ahlmahz's insightful question of the week: What's the overlap between energy justice and energy assistance?“Jenkins et al. [49] review three core tenets of energy justice: 1) distributional justice, relating to equal distribution of both the costs and benefits of the energy system; 2), recognition justice, relating to the fair representation of individuals; and 3) procedural justice, providing equal access to decision making processes.”From Who is marginalized in energy justice? Amplifying community leader perspectives of energy transitions in Ghana, Section 1:1:18:27 - from Human Batteries to Solarpunk - a new Public Power Underground game! Ezra Klein podcast: What the heck is going on with UFO stories? Monk and Robot series by Becky Chambers Futurama The Fifth Element The Matrix Avatar Men in Black WALL-E Strange World Mad Max Iron Man Public Power Underground, for electric utility enthusiasts! Public Power Underground, it's work to watch!

In this episode of the Epigenetics Podcast, we talked with Alistair Boettiger from Stanford University about his work on the analysis of 3D chromatin structure of single cells using super-resolution imaging. Alistair Boettiger and his team focus on developing advanced microscopy techniques to understand gene regulation at the level of 3D genome organization. They have developed Optical Reconstruction of Chromatin Architecture (ORCA), a microscopy approach to trace the 3-dimensional DNA path in the nucleus with genomic resolution down to 2 kb and a throughput of ~10,000 cells per experiment. These methods enable the identification of structural features with comparable resolution to Hi-C, while the advantages of microscopy such as single cell resolution and multimodal measurements remain.   References Boettiger, A., Bintu, B., Moffitt, J. et al. Super-resolution imaging reveals distinct chromatin folding for different epigenetic states. Nature 529, 418–422 (2016). https://doi.org/10.1038/nature16496 Bogdan Bintu et al., Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells. Science 362, eaau1783 (2018). DOI:10.1126/science.aau1783 Mateo, L.J., Sinnott-Armstrong, N. & Boettiger, A.N. Tracing DNA paths and RNA profiles in cultured cells and tissues with ORCA. Nat Protoc 16, 1647–1713 (2021). https://doi.org/10.1038/s41596-020-00478-x Rajpurkar, A.R., Mateo, L.J., Murphy, S.E. et al. Deep learning connects DNA traces to transcription to reveal predictive features beyond enhancer–promoter contact. Nat Commun 12, 3423 (2021). https://doi.org/10.1038/s41467-021-23831-4 Tzu-Chiao Hung, David M. Kingsley, & Alistair Boettiger. (2023). Boundary stacking interactions enable cross-TAD enhancer-promoter communication during limb development. BioRxiv, 2023.02.06.527380. https://doi.org/10.1101/2023.02.06.527380 Hafner, A., Park, M., Berger, S. E., Murphy, S. E., Nora, E. P., & Boettiger, A. N. (2023). Loop stacking organizes genome folding from TADs to chromosomes. Molecular cell, 83(9), 1377–1392.e6. https://doi.org/10.1016/j.molcel.2023.04.008   Related Episodes Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden) Unraveling Mechanisms of Chromosome Formation (Job Dekker) Biophysical Modeling of 3-D Genome Organization (Leonid Mirny)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

In the UK someone is diagnosed with cancer every two minutes. Every 4 minutes, someone dies of cancer. Startling statistics indeed, but did you know that human microbiomes, and the gut microbiome in particular, is pivotal to every aspect of cancer prevention, treatment response ,recovery and survivorship?Given the importance of the subject, your loyal microbiome nerds, Dr Sheena and Dr Shiv, have chosen to allocate not one , not two, but three episodes of Microbiome Medics Podcast to this rapidly evolving and complex area of research.In this first episode they get down and dirty with a cancer cell to figure out exactly how and why your resident gut micro-organisms might just be one of the most important resources you can utilise to harness the mighty power of your body's remarkable and extensive anti-cancer systems. Dr Shiv thinks she can get you to fall in love with her favourite gut microbiome research paper and Dr Sheena gets all hot under the collar about the effect of sweeteners on gut microbiome function. Enjoy.The paper discussed in this episode is:O'Keefe SJ et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun. 2015 Apr 28;6:6342. doi: 10.1038/ncomms7342.Chakalaka recipe link: https://www.wikihow.life/Make-ChakalakaThis podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.Disclaimer:The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this episode, I talk with Laura Gwilliams, soon-to-be Assistant Professor of Psychology, Neuroscience, and Data Science at Stanford University, about her recent paper ‘Neural dynamics of phoneme sequences reveal position-invariant code for content and order'.Gwilliams lab websiteGwilliams L, King JR, Marantz A, Poeppel D. Neural dynamics of phoneme sequences reveal position-invariant code for content and order. Nat Commun 2022; 13: 6606. [doi]

Ostriches are one of the strangest birds we've ever talked about. They are the world's biggest bird and toughest survivor. They nest together, have radiators for necks, and can drink saltwater. Photos and more are at our site. Primary Sources: "Strangest Bird Alive". 2016. National Geographic. Documentary. Schou, M.F., Bonato, M., Engelbrecht, A. et al. Extreme temperatures compromise male and female fertility in a large desert bird. Nat Commun 12, 666 (2021). https://doi.org/10.1038/s41467-021-20937-7 Knut Schmidt-Nielsen, John Kanwisher, Robert C. Lasiewski, Jerome E. Cohn, William L. Bretz, Temperature Regulation and Respiration in the Ostrich, The Condor, Volume 71, Issue 4, 1 October 1969, Pages 341–352, https://doi.org/10.2307/1365733 Contact Website Facebook Twitter info@grasslandgroupies.org

Over the years, I've noticed that people veer away from supplements with complicated-sounding names like nicotinamide riboside (NR). That could be what's kept people in the dark so much about this specific form of vitamin B3. I have to admit that I ignored it for a while, when research papers began emerging several years ago, as well. But the health and fitness benefits are too good to ignore, which is why I decided it was time to write a guide covering what it is, how you might benefit from using it, how much to use, and a few other details about NR. You'll quickly see how it could be helpful for you or someone you know. What is Nicotinamide Riboside (NR)? Nicotinamide Riboside (NR) is a naturally occurring form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme found in all living cells, NR maintains cellular energy and supports various biological processes.Canto, C., Menzies, K. J., & Auwerx, J. (2015). NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell metabolism, 22(1), 31-53. https://doi.org/10.1016/j.cmet.2015.05.023 NAD+ is essential for cellular metabolism, DNA repair, and proper functioning of the mitochondria, the "powerhouses of the cell." As we age, our NAD+ levels naturally decline, contributing to various age-related health issues.Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213. https://doi.org/10.1126/science.aac4854 Research suggests that supplementation with NR may help boost NAD+ levels and combat these effects, improving overall health and well-being.Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547. https://doi.org/10.1016/j.cmet.2018.02.011 You get trace levels of NR from dietary sources, such as milk, yeast, and some vegetables, but to consume NR at therapeutic levels, you need to supplement with it. Unlike other forms of vitamin B3, such as niacin and nicotinamide, NR maintains a better safety profile and produces fewer side effects.Conze, D., Brenner, C., & Kruger, C. L. (2019). Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific Reports, 9(1), 9772. https://doi.org/10.1038/s41598-019-46120-z Fitness and Performance Benefits NR supplementation can improve muscle function, increase endurance, and enhance cellular energy production, making it a valuable supplement, especially for aging athletes. Improved Muscle Function One of the key benefits of NR supplementation is its positive impact on muscle function. An animal study found that NR supplementation increased muscle strength and improved exercise capacity. This is believed to result from NR's role in boosting nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, including energy metabolism and mitochondrial function.Trammell SA, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948. doi: 10.1038/ncomms12948 By enhancing NAD+ levels, NR supplementation may help promote muscle health and function, making it a valuable addition to any fitness regimen. Increased Endurance NR supplementation increases endurance performance, too. Another animal study demonstrated that supplementation with NR increased endurance due to the activation of sirtuin 1 (SIRT1), a protein critical in regulating energy metabolism and mitochondrial biogenesis.Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., ... & Sauve, A. A. (2012). The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism, 15(6), 838-847.

In this episode of Mommy Brain Revisited I talk with Dr. Elseline Hoekzema, Assistant Professor, Adult Psychiatry and Amsterdam Neuroscience at Amsterdam University Medical Centers. We talk about her recent research published Nature Communications on how pregnancy impacts brain structure and function. This is a fascinating area of research! Download the publication here: https://www.nature.com/articles/s41467-022-33884-8 For more information about Dr. Hoekzema see: https://www.amsterdamumc.org/en/research/researchers/elseline-a.-hoekzema.htm Citation: Hoekzema, E., van Steenbergen, H., Straathof, M. et al. Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture. Nat Commun 13, 6931 (2022). https://doi.org/10.1038/s41467-022-33884-8 For more about Dr. Jodi Pawluski see: www.jodipawluski.com --- Support this podcast: https://anchor.fm/mommybrainrevisited/support

Jacob Mays, PhD, Matt Schroettnig, Ahlmahz Negash, PhD, and Paul Dockery discuss a paper Prof. Mays co-authored on contractual form in electricity reliability obligations, how it applies to the program getting developed in the Northwest, and what perspective he has on electric market development in the Northwest.06:52 - discuss recently published article by Professor Mays and Han Shu Shu, Han, and Jacob Mays. "Beyond capacity: contractual form in electricity reliability obligations." arXiv preprint arXiv:2210.10858 (2022). episode from the last time Prof. Mays was on Public Power Underground 23:54 - applying Prof. Mays insights to the Western Power Pool's Western Resource Adequacy Program47:27 - thoughts on the NYT article on electric utility deregulation Why are Energy Prices so High? Some Experts Blame Deregulation by Ivan Penn twitter thread by @MichaelGiberso3 in response to the article substack post on  Knowledge Problem by Lynn Kiesling RTO Insider article in response to the NY Times piece Ari Pesckoe twitter thread in response to the article 54:56 - New Segment!: Ahlmahz's Insightful Question of the Week!1:01:43 - Short to Ground; where we TL;DR our way through the rest of the news NWPCC: NW Needs More Reserves to Maintain Resource Adequacy Pause in Storms Allows Utilities, State Responders Valuable Time to Regroup Washington State Report: Salmon Remain ‘In Crisis' IOUs Report Significant Demand Reduction With Time-of-Use Rates With EVs PG&E, Energy Vault Seek OK for Biggest U.S. Long-Duration Storage System Eugene Board Votes to Develop Decommissioning Plan Goforth, T., Nock, D. Air pollution disparities and equality assessments of US national decarbonization strategies. Nat Commun 13, 7488 (2022). https://doi.org/10.1038/s41467-022-35098-4 Texas PUC nears market redesign decision amid criticism performance credit will not spur new generation Rachel Dibble has been named the vice president of bulk marketing at the Bonneville Power Administration Spot Market Power La Nina NOAA Climate Forecasts WY2023 Water Supply Forecast 1:11:53 - we talk a lot more about Texas's controversial Performance Credit MechanismYou can find the podcast on Apple Podcast, Spotify, or wherever you get your podcasts. Remember to share this with any friends you have that are electric utility enthusiasts like us!Public Power Underground, for electric utility enthusiasts! Public Power Underground, where you're valued and appreciated.

In this episode of the Epigenetics Podcast, we caught up with Melissa Harrison from the University of Wisconsin-Madison to talk about her work on the “Pioneer” Transcription Factors - Zelda and Grainyhead - and their role at the maternal-to-zygotic transition. The Harrison lab studies how differentiation and development are driven by coordinated changes in gene expression. To do this, the targets of choice are the transcription factors Zelda and Grainyhead that bind to the genome at specific and crucial points in development and differentiation. These specialised transcription factors have the ability to bind to DNA in the context of nucleosomes which defines regulatory elements and leads to subsequent binding of additional classical transcription factors. These properties allow pioneer factors to act at the top of gene regulatory networks and control developmental transitions.   References Harrison, M. M., Botchan, M. R., & Cline, T. W. (2010). Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Developmental biology, 345(2), 248–255. https://doi.org/10.1016/j.ydbio.2010.06.026 Harrison, M. M., Li, X. Y., Kaplan, T., Botchan, M. R., & Eisen, M. B. (2011). Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS genetics, 7(10), e1002266. https://doi.org/10.1371/journal.pgen.1002266 McDaniel, S. L., Gibson, T. J., Schulz, K. N., Fernandez Garcia, M., Nevil, M., Jain, S. U., Lewis, P. W., Zaret, K. S., & Harrison, M. M. (2019). Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Molecular cell, 74(1), 185–195.e4. https://doi.org/10.1016/j.molcel.2019.01.014 McDaniel, S. L., & Harrison, M. M. (2019). Optogenetic Inactivation of Transcription Factors in the Early Embryo of Drosophila. Bio-protocol, 9(13), e3296. https://doi.org/10.21769/BioProtoc.3296 Larson, E.D., Komori, H., Gibson, T.J. et al. Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila. Nat Commun 12, 7153 (2021). https://doi.org/10.1038/s41467-021-27506-y   Related Episodes Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

What if tackling the world's biggest problem, climate change, was not actually the world's biggest problem? What if solving happiness was - and in restoring happiness we would create a healthier planet? In episode #175 Environmental Scientist Nicholas Carter returns to give us an update on the health of our planet, explain what COP26 is, and offer a suggestion for what we may actually need to consider if we are going to create a brighter future for humanity. Hope you enjoy it. Resources: World Resources Institute: Half a Degree and a World Apart: The Difference in Climate Impacts Between 1.5˚C and 2˚C of Warminghttps://www.wri.org/insights/half-degree-and-world-apart-difference-climate-impacts-between-15c-and-2c-warming Animal Agriculture is the predominant source of methane accounting for roughly 32 percent of human-caused methane emissions. https://www.unep.org/news-and-stories/story/methane-emissions-are-driving-climate-change-heres-how-reduce-them 30% of historical cumulative CO₂ emissions are from land-use change. If the starting point is 1750 or earlier, this share just goes up (2020 Global Carbon Budget https://essd.copernicus.org/articles/12/3269/2020/) | https://ourworldindata.org/carbon-opportunity-costs-food Wiedmann, T., Lenzen, M., Keyßer, L.T. et al. Scientists' warning on affluence. Nat Commun 11, 3107 (2020). https://www.nature.com/articles/s41467-020-16941-y?fbclid=IwAR0AG6Lz_CcR2XY0uxVvKNmjnlWP0YLXl6iBcUfl8gcZmTjR7-ZVb3W3oes#citeas Jason Hickel (2019) Is it possible to achieve a good life for all within planetary boundaries?, Third World Quarterly, 40:1, 18-35, DOI: 10.1080/01436597.2018.1535895 https://www.tandfonline.com/doi/abs/10.1080/01436597.2018.1535895 O'Neill et al (2018). A good life for all within planetary boundaries. Nature Sustainability, 1, 88. https://www.nature.com/articles/s41893-018-0021-4 Is Green Growth Possible? https://www.tandfonline.com/doi/abs/10.1080/13563467.2019.1598964?journalCode=cnpe20 Jason Hickel (2021) What does degrowth mean? A few points of clarification, Globalizations, 18:7, 1105-1111, DOI: 10.1080/14747731.2020.1812222 https://www.tandfonline.com/doi/full/10.1080/14747731.2020.1812222 77–100% of marginal agricultural lands (in New Zealand) could financially benefit from afforestation. West, Thales AP, et al. "Promotion of afforestation in New Zealand's marginal agricultural lands through payments for environmental services." Ecosystem Services 46 (2020): 101212. ~80% of soy goes to animal agriculture https://ourworldindata.org/soy "All undisturbed natural ecosystems contain more soil organic carbon than their agricultural counterparts that, on average, sequester 25–75% less." Rattan Lal, Managing Soils and Ecosystems for Mitigating Anthropogenic Carbon Emissions and Advancing Global Food Security, BioScience, Volume 60, Issue 9, October 2010, Pages 708–721, https://doi.org/10.1525/bio.2010.60.9.8 University of Alberta meta-analysis on grazing vs. removing grazing: Filazzola, Alessandro, et al. "The effects of livestock grazing on biodiversity are multi‐trophic: a meta‐analysis." Ecology letters 23.8 (2020): 1298-1309. https://onlinelibrary.wiley.com/doi/epdf/10.1111/ele.13527 You want to reduce the carbon footprint of your food? Focus on what you eat, not whether your food is local https://ourworldindata.org/food-choice-vs-eating-local Want to support the show? If you are enjoying the Plant Proof podcast a great way to support the show is by leaving a review on the Apple podcast app. It only takes a few minutes and helps more people find the episodes. It's also helpful to subscribe on Apple Podcast app and/or follow on the Spotify Podcast app. Simon Hill, Nutritionist, Sports Physiotherapist Creator of Plantproof.com and host of the Plant Proof Podcast Author of The Proof is in the Plants Connect with me on Instagram and Twitter Download my FREE two week meal plan Download my FREE blood test and supplement guides here