Podcasts about N6

OpenMV has a new Kickstarter so CEO Kwabena Agyeman chatted with us about more powerful (and smaller!) programmable cameras.  See OpenMV's site for their existing cameras. See their (already funded!) kickstarter page for the super powerful N6 and the ridiculously small AE3. Note that OpenMV still is committed to open source. See their github if you want to know more. Edge AI is the idea of putting intelligence in the devices (instead of in the cloud). There is an advocacy and education foundation called Edge AI Foundation. This organization was formerly the TinyML Foundation. Edge Impulse and Roboflow are companies that aid in creating and training AI models that can be put on devices.  ARM talks about their Ethos-U55 NPU (and how to write software for it). Transcript

Ten people have died and about 30 inquired following an accident involving a truck and a bus on the N6 between Reddersburg and Springfield in the Free State. The road had to be closed and traffic diverted as a result. Free State Emergency Medical Services officials are attending to the trapped and injured passengers. The injured have been transported to hospitals in Bloemfontein and the nearby Springfield. Sakina Kamwendo spoke to SABC reporter, Ishmael Modiba in the Free State

In this episode of the Epigenetics Podcast, we talked with Natalia Gromak from the University of Oxford about her work on R-Loop biology in health and disease. In this interview Dr. Gromak delves into her significant research on transcription and RNA biology, particularly focusing on the molecular mechanisms involved at transcriptional pause sites. She describes her early work in understanding transcription termination and how her team investigated the role of specific RNA and DNA structures, including R-loops, that could influence polymerase progression. This exploration into R-loops—complexes formed by RNA and DNA interactions—was a key turning point in her research, as she and her colleagues identified their regulatory functions within the human genome. Discussion transitions into her findings regarding the implications of R-loops in diseases like Friedrich's ataxia and Fragile X syndrome. Dr. Gromak then elucidates how the pathological expansion of repeat sequences in these conditions interferes with normal gene expression, and how R-loops exacerbate transcriptional silencing. Throughout her reflection on these discoveries, she emphasizes the importance of studying R-loops beyond merely being a transcriptional byproduct, but as players in gene regulation and potential contributors to disease pathology. The episode also covers her innovative work in characterizing the R-loop interactome through various experimental techniques. She highlights the complexity of R-loop dynamics, including the discovery of protein factors that interact with R-loops and could influence their stability and regulatory functions. Furthermore, she discusses the exciting intersection of RNA modifications, such as m6A, which plays a role in R-loop regulation and presents new avenues for research, particularly pertaining to how disease-specific modifications might alter R-loop behavior.   References Cristini, A., Groh, M., Kristiansen, M. S., & Gromak, N. (2018). RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage. Cell reports, 23(6), 1891–1905. https://doi.org/10.1016/j.celrep.2018.04.025 Abakir, A., Giles, T. C., Cristini, A., Foster, J. M., Dai, N., Starczak, M., Rubio-Roldan, A., Li, M., Eleftheriou, M., Crutchley, J., Flatt, L., Young, L., Gaffney, D. J., Denning, C., Dalhus, B., Emes, R. D., Gackowski, D., Corrêa, I. R., Jr, Garcia-Perez, J. L., Klungland, A., … Ruzov, A. (2020). N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature genetics, 52(1), 48–55. https://doi.org/10.1038/s41588-019-0549-x   Related Episodes DNA Replication, Transcription and R-loops (Stephan Hamperl)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Yannick und Su erzählten live im Studio mehr über den Regenbogentreff für alle Kinder und Jugendlichen zwischen 7 bis 15 Jahren, die sich unter dem Regenbogen verstehen. Der Treff befindet sich in Bern im N6. Komplette Sendung: ⁠⁠⁠⁠⁠www.queerupradio.ch⁠

Nem jön ki a matek ITBusiness     2024-09-11 09:37:28     Cégvilág Infotech Még mindig tájékozatlan cégek garmadája, messze nem elegendő számú szakember, betarthatatlan határidők, hiányzó jogszabályok – a NIS2 előírásaira való felkészülés nem megy olyan zökkenőmentesen, mint ahogy azt az év elején remélték a szakértők. ◼︎ Hajrájához közeledik a NIS2 Június végén megjelent két, a NIS2-re való felkészülés szempontjából alapv Elégedetlenek és csalódottak a kínai iPhone 16 vásárlók ICT Global     2024-09-11 06:03:13     Mobiltech Kína Telefon Mesterséges intelligencia Apple Okostelefon iPhone Az új iPhone kínai verziója, amelyből most kimaradtak a mesterséges intelligenciára épülő funkciók, kimondott csalódást okozott a világ legnagyobb mobilpiacán - számolt be az Apple új telefonszériájának ázsiai fogadtatásáról a Reuters. Háromfelé hajtható telefont mutatott be a Huawei Player     2024-09-11 08:00:23     Mobiltech Telefon Huawei Ha azt hitted, hogy a hajtogatható telefonok közt már nem lehet újat mutatni, akkor nézd meg a Huawei újdonságát! A Mate Xt ugyanis háromfelé hajtható, ezért teljesen kihajtogatva tényleg képes kiváltani egy nagyobb táblagépet. Öt éven belül jöhet a színváltós BMW InStyle Men     2024-09-11 04:10:50     Infotech BMW Az autó az E-Ink technológia segítségével változtathatja a színét. Még ebben az évtizedben sorozatgyártásba mehet. A jelszómentes biztonság jövője Igényesférfi.hu     2024-09-11 10:39:21     Infotech Samsung A Samsung kiemelten fontosnak tartja, hogy az összekapcsolt eszközök ökoszisztémájának használata során nyugalmat biztosítson: a Knox Vault, a jelkulcsok és a Knox Matrix egytől egyig megvédik a felhasználókat és digitális életüket. Kicsit közelebb kerültünk hozzá, hogy a robotporszívók a lépcsőkkel is megbirkózzanak Rakéta     2024-09-11 07:54:04     Infotech Németország Kiállítás Berlin Robot A berlini IFA kiállításon a Roborock valamint a Dreame is olyan technológiát mutatott be, amellyel a robotporszívó meg tudja emelni az elejét, így akár négy centiméter magas akadalyokon is át tud kelni. Az üstökösei után új földközeli kisbolygókat talált Sárneczky Mínuszos     2024-09-11 10:33:04     Tudomány Világűr Második magyarként augusztusban választották be a Nemzetközi Csillagászati Unió (IAU) legújabb tiszteletbeli tagjai közé Sárneczky Krisztiánt, aki júliusban két üstököst fedezett fel egy héten belül, és aki a napokban több új kisbolygót is talált. Tizenöt új tiszteletbeli tagot választott az IAU, akiket az augusztusi közgyűlésükön jelentettek be. M Semmelweis: Egyre több az allergiás beteg a géllakk összetevői miatt Telex     2024-09-11 09:57:32     Tudomány Allergia A körömszépészeti termékekben előforduló vegyi anyagok közül az úgynevezett akrilátorok okozzák a legtöbb allergiás megbetegedést. A hosszú élet molekuláris titkát fedezték fel magyar tudósok PlanetZ     2024-09-11 08:00:12     Tudomány DNS Magyar kutatók felfedezték az öregedési folyamat egyik kulcsfontosságú epigenetikai összetevőjét. Ez új lehetőségeket nyit a hosszú élet és az egészséges öregedés terén. A mitokondriális DNS-ben talált N6-metiladenin (6mA) felhalmozódása forradalmasíthatja az öregedéssel összefüggő betegségek kezelését. Megmérték, hogy a magyarok mennyire kaptak rá a mesterséges intelligenciára Bitport     2024-09-11 10:46:00     Infotech Mesterséges intelligencia Generáció Egy friss hazai kutatás alacsony felkészültségi szintről és jelentős generációs, illetve felhasználási különbségekről számol be az MI technológiák hazai alkalmazásában. Kína visszautasítja az atomfegyverek feletti AI ellenőrzés tilalmát ICT Global     2024-09-11 15:33:26     Infotech Kína Mesterséges intelligencia Kína nem hajlandó aláírni azt a megállapodást, amely megtiltja a mesterséges intelligenciának az atomfegyverek ellenőrzését. Októbertől ismét indul az ösztöndíjas Net-Coach képzés Digital Hungary     2024-09-11 12:06:08     Média Oktatás Mesterséges intelligencia Katolikus NMHH Médiatanács Coach Az okoseszközök szolgáltatásai és a mesterséges intelligencia egyre nagyobb kihívást jelentenek diákoknak, szülőknek és tanároknak egyaránt. A Nemzeti Média- és Hírközlési Hatóság (NMHH) és az Apor Vilmos Katolikus Főiskola közös kezdeményezésével indult Net-Coach program a magyar pedagógusokkal és más szakemberekkel összefogva olyan tudásközössége Egy magyar építésziroda űrtechnológiával keres ellenszert a városi hőségre Roadster     2024-09-11 09:06:05     Otthon Energia Kánikula Világűr Műhold Műholdas földmegfigyelési adatokkal dolgozik a városi hőszigethatás csökkentésén, és az ingatlanfejlesztések energiahatékonyságának javításán a Paulinyi & Partners iroda az Európai Űrügynökséggel közösen. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

Nem jön ki a matek ITBusiness     2024-09-11 09:37:28     Cégvilág Infotech Még mindig tájékozatlan cégek garmadája, messze nem elegendő számú szakember, betarthatatlan határidők, hiányzó jogszabályok – a NIS2 előírásaira való felkészülés nem megy olyan zökkenőmentesen, mint ahogy azt az év elején remélték a szakértők. ◼︎ Hajrájához közeledik a NIS2 Június végén megjelent két, a NIS2-re való felkészülés szempontjából alapv Elégedetlenek és csalódottak a kínai iPhone 16 vásárlók ICT Global     2024-09-11 06:03:13     Mobiltech Kína Telefon Mesterséges intelligencia Apple Okostelefon iPhone Az új iPhone kínai verziója, amelyből most kimaradtak a mesterséges intelligenciára épülő funkciók, kimondott csalódást okozott a világ legnagyobb mobilpiacán - számolt be az Apple új telefonszériájának ázsiai fogadtatásáról a Reuters. Háromfelé hajtható telefont mutatott be a Huawei Player     2024-09-11 08:00:23     Mobiltech Telefon Huawei Ha azt hitted, hogy a hajtogatható telefonok közt már nem lehet újat mutatni, akkor nézd meg a Huawei újdonságát! A Mate Xt ugyanis háromfelé hajtható, ezért teljesen kihajtogatva tényleg képes kiváltani egy nagyobb táblagépet. Öt éven belül jöhet a színváltós BMW InStyle Men     2024-09-11 04:10:50     Infotech BMW Az autó az E-Ink technológia segítségével változtathatja a színét. Még ebben az évtizedben sorozatgyártásba mehet. A jelszómentes biztonság jövője Igényesférfi.hu     2024-09-11 10:39:21     Infotech Samsung A Samsung kiemelten fontosnak tartja, hogy az összekapcsolt eszközök ökoszisztémájának használata során nyugalmat biztosítson: a Knox Vault, a jelkulcsok és a Knox Matrix egytől egyig megvédik a felhasználókat és digitális életüket. Kicsit közelebb kerültünk hozzá, hogy a robotporszívók a lépcsőkkel is megbirkózzanak Rakéta     2024-09-11 07:54:04     Infotech Németország Kiállítás Berlin Robot A berlini IFA kiállításon a Roborock valamint a Dreame is olyan technológiát mutatott be, amellyel a robotporszívó meg tudja emelni az elejét, így akár négy centiméter magas akadalyokon is át tud kelni. Az üstökösei után új földközeli kisbolygókat talált Sárneczky Mínuszos     2024-09-11 10:33:04     Tudomány Világűr Második magyarként augusztusban választották be a Nemzetközi Csillagászati Unió (IAU) legújabb tiszteletbeli tagjai közé Sárneczky Krisztiánt, aki júliusban két üstököst fedezett fel egy héten belül, és aki a napokban több új kisbolygót is talált. Tizenöt új tiszteletbeli tagot választott az IAU, akiket az augusztusi közgyűlésükön jelentettek be. M Semmelweis: Egyre több az allergiás beteg a géllakk összetevői miatt Telex     2024-09-11 09:57:32     Tudomány Allergia A körömszépészeti termékekben előforduló vegyi anyagok közül az úgynevezett akrilátorok okozzák a legtöbb allergiás megbetegedést. A hosszú élet molekuláris titkát fedezték fel magyar tudósok PlanetZ     2024-09-11 08:00:12     Tudomány DNS Magyar kutatók felfedezték az öregedési folyamat egyik kulcsfontosságú epigenetikai összetevőjét. Ez új lehetőségeket nyit a hosszú élet és az egészséges öregedés terén. A mitokondriális DNS-ben talált N6-metiladenin (6mA) felhalmozódása forradalmasíthatja az öregedéssel összefüggő betegségek kezelését. Megmérték, hogy a magyarok mennyire kaptak rá a mesterséges intelligenciára Bitport     2024-09-11 10:46:00     Infotech Mesterséges intelligencia Generáció Egy friss hazai kutatás alacsony felkészültségi szintről és jelentős generációs, illetve felhasználási különbségekről számol be az MI technológiák hazai alkalmazásában. Kína visszautasítja az atomfegyverek feletti AI ellenőrzés tilalmát ICT Global     2024-09-11 15:33:26     Infotech Kína Mesterséges intelligencia Kína nem hajlandó aláírni azt a megállapodást, amely megtiltja a mesterséges intelligenciának az atomfegyverek ellenőrzését. Októbertől ismét indul az ösztöndíjas Net-Coach képzés Digital Hungary     2024-09-11 12:06:08     Média Oktatás Mesterséges intelligencia Katolikus NMHH Médiatanács Coach Az okoseszközök szolgáltatásai és a mesterséges intelligencia egyre nagyobb kihívást jelentenek diákoknak, szülőknek és tanároknak egyaránt. A Nemzeti Média- és Hírközlési Hatóság (NMHH) és az Apor Vilmos Katolikus Főiskola közös kezdeményezésével indult Net-Coach program a magyar pedagógusokkal és más szakemberekkel összefogva olyan tudásközössége Egy magyar építésziroda űrtechnológiával keres ellenszert a városi hőségre Roadster     2024-09-11 09:06:05     Otthon Energia Kánikula Világűr Műhold Műholdas földmegfigyelési adatokkal dolgozik a városi hőszigethatás csökkentésén, és az ingatlanfejlesztések energiahatékonyságának javításán a Paulinyi & Partners iroda az Európai Űrügynökséggel közösen. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

@nigeriasbest and @phoenix_agenda were joined by @keneike They discussed:1. Dangote responds to NMDPRA chief's claims.2. Supreme Court issues landmark judgement affirming Local Government fiscal autonomy.3. Tinubu asks NASS to increase 2024 budget by N6.2 Trillion.4. Protests planned across Nigeria from 1st August.

Eastern Cape traffic officials have closed Barkly Pass, on the R58 route between Barkly East and Elliot, this morning due to heavy snowfalls. The Eastern Cape Transport Department says some vehicles are stuck in the snow on the R58. Authorities are also keeping an eye on snowfall-prone routes such as Penhoek Pass on the N6 between Komani and Jamestown and others mainly in mountainous areas. Sakina Kamwendo spoke to Eastern Cape Transport Department spokesperson, Unathi Binqose

The National Hajj Commission of Nigeria, (NAHCON) has declared an increase in the fare for the 2024 Hajj pilgrimage to Saudi Arabia with an additional rise of N1,918,032.91 to bring the total cost to an unprecedented N6.8 million.What is the fate of those who have already made payment?Join us in this episode of our Daily podcast as we find out.

On Entrepreneur feature we talk to Seth Mulli, Allan Gray Makers Programme Director, about their The Allan Gray Makers StartUp Academy which is a fully funded 8-month incubation program for aspiring artisan entrepreneurs in the Plumbing and Electrical trades. Applications are still opened and Seth joins us to tell more about the incubation program.   The Allan Gray Makers Academy is that helping hand, empowering technically talented youth with the skills and exposure needed to embark on their entrepreneurial journey," says Seth Mulli, Programme Director at Allan Gray Makers. Who Can Apply? The Allan Gray Makers StartUp Academy welcomes applications from individuals who meet the following criteria: South African citizen or permanent resident Qualified plumber or electrician (N6 qualification) Completed or eligible to take a Trade Test Age 18 to 35 (35 at the time of graduation, 18 at the time of application) Based in Gauteng, Eastern Cape, KwaZulu-Natal, or Mpumalanga Desire to start your own business Working in the electrical or plumbing industry with a completed apprenticeship (minimum 18 months) What Participants Will Gain: Successful applicants to the programme will benefit from: Training in entrepreneurial mindset development, new venture creation, marketing and sales, business management, financial management, branding, business e-skills, and personal mastery. Opportunities to work in teams and network with other businesses.Access to personal mentorship, business shadowing, industry-expert coaches, and business advisory. Access to markets with a focus on making your first sale. Graduates will have access to life-long support. How to Apply:Applications are now open, and interested individuals are encouraged to apply by visiting www.allangraymakers.co.za  or whatsapp: 066 579 7616  The deadline for applications is midnight on February 7, 2024.See omnystudio.com/listener for privacy information.

QD264 - To Aspirate or Not https://youtu.be/ek25MJ0dI7g?si=SKLnw92gkJeFw0BM QD265 - Suspend MTX How Long  https://youtu.be/N6-m-IDrnFc QD266 - GCA & Steroid Weaning https://youtu.be/Vyzd5_lMi_k QD267 - RA, SSZ, & MI https://youtu.be/p9uzqk6VO1s QD268 - ISR Management https://youtu.be/tztFzdA_oog

Jon and Matt discuss brand communications in today's market. In the age of COVID-19, three brand communication principals to follow are: classy, smart and fast. Matt Rizzetta is the President and CEO of North 6th Agency, Inc. (N6A), a leading brand communications agency based in New York City. Under Rizzetta's leadership, N6A has been ranked as the #1 fastest-growing agency in the United States in its revenue category by O'Dwyers. N6A has been awarded several prestigious industry recognitions, including New York Observer Power Agency List, Summit International Award, PR News Marketing and PR Leader of the Year, and has been selected as one of the “coolest spaces at the hottest PR firms” by the New York Observer. Rizzetta has been instrumental in developing N6A's internal and external KPI measurement system, and has created a culture at N6A that has been lauded as one of the most rewarding, collaborative and unique in the agency landscape. Among the signature programs that Rizzetta has developed at N6A are the N6A 6PA Performance Ranking System, “N6-get-Away” vacation competition, “N6A Bucket List Weekend” competition, “N6-leg-Acy” PTO package, “N6A Chairman's Pick” award, and many more. Rizzetta serves as a board member at Iona College, and currently resides in Westchester County, NY with his wife and three daughters.   Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon's Book: The Think Big Movement: Grow your business big. Very Big!   Connect with Matt Rizzetta: Twitter: @North6thAgency Website:  www.n6a.com  www.competeandcare.com Email:  mrizetta@n6a.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.06.535853v1?rss=1 Authors: Danan, C. H., Naughton, K. E., Hayer, K. E., Vellapan, S., McMillan, E. A., Zhou, Y., Matsuda, R., Nettleford, S. K., Katada, K., Parham, L. R., Ma, X., Chowdhury, A., Wilkins, B. J., Shah, P., Weitzman, M. D., Hamilton, K. E. Abstract: The METTL3-METTL14 methyltransferase complex adds N6-methyladenosine (m6A) to mRNA with profound impacts on cell fate. Studies delete METTL3 or METTL14 interchangeably to define the role of m6A in target tissues despite a lack of data confirming that these deletions are equivalent. Intestinal epithelial METTL14 deletion triggers stem cell death in the colon with no overt phenotype in the small intestine. The effect of METTL3 deletion in the same tissues remains unknown. We report that intestinal epithelial METTL3 deletion caused unexpected severe defects in the small intestine, including crypt and villus atrophy associated with cellular senescence and death in the crypt transit amplifying zone. Ribosome profiling and m6A-sequencing demonstrated downregulated translation of hundreds of unique methylated transcripts, including genes essential to growth factor signal transduction, such as Kras. Our study suggests that METTL3 is essential for small intestinal homeostasis via enhanced translation of growth factor signaling in crypt transit amplifying cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.28.534515v1?rss=1 Authors: Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Kilci, A., Jenkins, M., Rashad, S., Sun, J., Dedon, P., Daley, S. A., Xia, W., Ortiz, A. R., Dorrian, L., Sado, T. C., Saido, T., Wolozin, B. Abstract: The study for the pathophysiology study of Alzheimers disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular {beta}-amyloid (A{beta}) deposition, intracellular aggregation of microtubule associated protein tau (MAPT), inflammation and neurodegeneration. We now report on a double transgenic APPNL-G-F MAPTP301S mouse that at 6 months of age exhibits robust A{beta} plaque accumulation, intense MAPT pathology, strong inflammation and extensive neurodegeneration. The presence of A{beta} pathology potentiated the other major pathologies, including MAPT pathology, inflammation and neurodegeneration. However, MAPT pathology neither changed levels of amyloid precursor protein nor potentiated A{beta} accumulation. The APPNL-G-F/MAPTP301S mouse model also showed strong accumulation of N6-methyladenosine (m6A), which was recently shown to be elevated in the AD brain. M6A primarily accumulated in neuronal soma, but also co-localized with a subset of astrocytes and microglia. The accumulation of m6A corresponded with increases in METTL3 and decreases in ALKBH5, which are enzymes that add or remove m6A from mRNA, respectively. Thus, the APPNL- G-F/MAPTP301S mouse recapitulates many features of AD pathology beginning at 6 months of aging. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The Federal Government's expenditure in the first six months of 2022 exceeded revenue by N6.23tn. The Federal Government recorded N3.2tn and N2.74tn fiscal deficit in the first and second quarters of 2022. It however exceeded the Federal Government's fiscal deficit budget of N1.6tn for the period under review. A breakdown revealed that recurrent expenditure, capital expenditure, and transfers accounted for 81.0 percent, 13.3 percent, and 5.7 percent of total expenditure, respectively. It noted that the fiscal operations of the Federal Government in the second quarter of 2022 remained aligned with the extant fiscal frameworks, which sought to achieve macroeconomic stability, improve revenue generation, and create fiscal space to boost infrastructural development, among other objectives.

A new review paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 19, entitled, “RNA modifications in aging-associated cardiovascular diseases.” Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide that bears an enormous healthcare burden. Aging is a major contributing factor to CVDs. Functional gene expression network during aging is regulated by mRNAs transcriptionally and by non-coding RNAs epi-transcriptionally. RNA modifications alter the stability and function of both mRNAs and non-coding RNAs and are involved in differentiation, development and diseases. In this new review paper, researchers Xinyu Yang, Priyanka Gokulnath, H. Immo Lehmann, Zhitao Hou, Sun Yang, Liangzhen You, Guoxia Zhang, Yanwei Xing, Ji Lei, Guoping Li, Shuwen Guo, and Hongcai Shang from Fangshan Hospital and Dongzhimen Hospital (affiliated with Beijing University of Chinese Medicine), Massachusetts General Hospital, Harvard Medical School, Heilongjiang University of Chinese Medicine, and Chinese Academy of Chinese Medical Sciences reviewed major chemical RNA modifications on mRNAs and non-coding RNAs, including N6-adenosine methylation, N1-adenosine methylation, 5-methylcytidine, pseudouridylation, 2′ -O-ribose-methylation, and N7-methylguanosine, in the aging process with an emphasis on cardiovascular aging. They also summarize the currently available methods to detect RNA modifications and the bioinformatic tools to study RNA modifications. “More importantly, we discussed the specific implication of the RNA modifications on mRNAs and non-coding RNAs in the pathogenesis of aging-associated CVDs, including atherosclerosis, hypertension, coronary heart diseases, congestive heart failure, atrial fibrillation, peripheral artery disease, venous insufficiency, and stroke.” DOI: https://doi.org/10.18632/aging.204311 Corresponding Authors: Guoping Li; Shuwen Guo; Hongcai Shang - Corresponding Emails: gli21@mgh.harvard.edu; guo1163@163.com; shanghongcai@bucm.edu.cn Keywords: RNA modifications, aging, aging-related cardiovascular diseases, epitranscriptome Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204311 About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Der Tech-Herbst geht weiter, Nvidia stellt die neue Grafikkartenreihe RTX 4000 vor und, zefix, die sind unverschämt teuer (und unverschämt benannt, looking at you RTX 4080 12GB).Die Playstation 5 geht einen Schritt zur nächsten Lebensphase mit einem Die-Shrink des SoC von N7- auf N6-Fertigung.Wir schauen nochmal auf den GTA6-Leak und freuen uns über unterhaltsame Einblicke in Alpha-Footage anderer Spiele.Logitech haben tatsächlich den Streaming-Handheld vorgestellt. Nächstes Thema. Twitch verbietet (teilweise) Casino- und Glücksspiel-Streams. Viel Spaß mit Folge 119! Sprecher: Mohammed Ali Dad, Michael Kister Besucht unsim Discord https://discord.gg/SneNarVCBMauf Twitter https://twitter.com/technikquatschund unserem Twitch-Kanal https://www.twitch.tv/technikquats 00:03:23 Nvidia stellt RTX 4000 vor: 4090, 4080 16GB und 4070 4080 12 GB; dazu DLSS 3 und RTX Remixhttps://www.computerbase.de/2022-09/geforce-rtx-4090-und-rtx-4080-ada-lovelace-fuer-899-dollar-bis-1-599-dollar-im-oktober-und-november/https://www.computerbase.de/2022-09/geforce-rtx-4000-dlss-3-founders-edition-technik/https://www.computerbase.de/2022-09/nvidia-rtx-remix-portal-und-morrowind-erstrahlen-im-neuen-glanz/ 00:41:01 PS5 SoC hat einen Die-Shrink von N7 auf N6 erhalten und heißt jetzt wohl Oberon Plushttps://www.angstronomics.com/p/ps5-refresh-oberon-plus 00:44:22 GTA6-Leak revisited: britischer Jugendlicher verhaftet, viel Alpha-Footage von anderen Spielenhttps://thedesk.net/2022/09/british-teen-arrested-rockstar-microsoft-uber-nvidia-hacks/https://twitter.com/InsiderGamingIG/status/1573394902939041805 00:52:22 Logitechs Ressourcenverschwendung: G Cloud Gaming Handheldhttps://www.computerbase.de/2022-09/g-cloud-gaming-handheld-logitechs-spielekonsole-startet-schon-im-oktober/ 00:59:55 Twitch beschränkt Casino- und Glücksspiel-Streamshttps://www.heise.de/news/Twitch-Einschraenkung-des-Gluecksspiels-und-Aenderung-an-Einnahmen-fuer-Streamer-7271758.html 01:04:15 Proteste in Iranhttps://snowflake.torproject.org/ Medien-Konsum01:08:57 Mortal Kombat (Film von 2019)01:15:34 Ryse: Son of Rome01:25:56 Wo Long: Fallen Dynastie Demo01:28:04 Marvel's Spider-Man PC

The Senate rejected the 2023-2025 medium-term expenditure framework and fiscal strategy paper which proposed A N6 trillion tax and import duties waivers proposed for in the N19.76 trillion 2023 budget which also contained A deficit of N12.4 trillion. The chairman of the senate panel, senator Solomon Adeola says that both the projected N12.43 trillion budget deficit and the n6trillion tax and import duty waivers should be critically reviewed downward before sending the proposals to the national assembly for consideration and approval. He also told the minister to look into the list of beneficiaries of the waivers for the required downward review to N3 trillion in order to give room for the reduction of the N12.43 trillion deficit figure.

#AduandTheGuru Discussing the following stories in the news; 1. Again, Senate on Trial over Buhari's Nomination of INEC's RECs – Thisday 2. Buhari increases duty tour allowance for ministers, perm secs, civil servant – Daily Trust 3. How we are securing Gulf of Guinea – Nigerian Navy – Premium Times 4. Endless Tussle between IG and PSC over Police Recruitment – Thisday 5. Wike speaks on Jibrin's resignation says Atiku assured him Ayu would vacate office – Premium Times 6. Military wares, cash found in Tukur Mamu's house – SSS – Premium Times 7. We Found Military Uniforms, Huge Cash In Tukur Mamu's House – DSS – Daily Trust 8. NNPC can't justify N6.34tn petrol subsidy – Customs – Punch 9. Navy disagrees with Petroleum Ministry, others over quantity of stolen oil – Vanguard

#AduandTheGuru Discussing the following stories in the news; * Wike, Others Were Children When We Started PDP ― Ayu – Tribune * BREAKING: We will help PDP lose election – Wike – Daily Post * NNPC can't justify N6.34tn petrol subsidy – Customs – Punch * Navy disagrees with Petroleum Ministry, others over quantity of stolen oil – Vanguard * Jonathan Narrates How He Spent Whole Night to Resolve ASUU Strike – Thisday * Pandora Papers: New UK law to end secret property investments by Nigerians, others – Premium Times * Pandora Papers: What failure to investigate, prosecute suspected ‘violators' may cost Nigeria – Premium Times * Nigeria Immigration explains different passport fees in Northern, Southern states – Daily Post #newsupdate #localnews

The N6 heads straight South from Bloemfontein and skirts the Southern border of Lesotho. Little towns like Reddersburg, Smithfield, Aliwal North and Jamestown all have some history of the conflicts with the Basotho, as well as many stories of Voortrekkers and Anglo Boer War characters. A little further south and once through Queenstown you are in "Settler Country" - but these were German settlers - not British. The Road Trip SA app is available for downloadDo you want to explore South Africa? Touch Africa Safaris

The N6 heads straight South from Bloemfontein and skirts the Southern border of Lesotho. Little towns like Reddersburg, Smithfield, Aliwal North and Jamestown all have some history of the conflicts with the Basotho, as well as many stories of Voortrekkers and Anglo Boer War characters. A little further south and once through Queenstown you are in "Settler Country" - but these were German settlers - not British. The Road Trip SA app is available for downloadDo you want to explore South Africa? Touch Africa Safaris

The International Monetary Fund has warned that the Nigerian government may spend nearly 100 per cent of its revenue on debt servicing by 2026. The IMF's Resident Representative for Nigeria, Ari Aisen, says the biggest critical aspect for Nigeria is that they have done a macro-fiscal stress test, and the interest payments as a share of revenue and as you see us in terms of the baseline from the federal government of Nigeria, the revenue, almost 100 per cent, is projected by 2026 to be taken by debt service. IMF also warned that with fuel subsidy payments averaging N500 billion monthly, total expenditure on subsidy could hit a record N6 trillion by the end of the year.

The International Monetary Fund warned that with Nigeria's fuel subsidy payout averaging N500 billion monthly, total expenditure on subsidy could hit a record N6 trillion mark by year-end. IMF's Resident Representative for Nigeria, Mr Ari Aisen revealed that Nigeria received a total of $6.8 billion in facilities from the IMF following the outbreak of the COVID-19 pandemic in 2020. The IMF chief expressed worry that many African countries, including Nigeria risk sliding into critical debt servicing problems unless urgent actions were explored to significantly raise revenue. Aisen noted that over 80 per cent of the federal government's revenue was committed to debt service, a situation he described as an existential problem

Doblegar la realidad es la ley N6 de los códigos de las mentes extraordinarias, son esas personas que son capaces de crear una visión lo suficientemente poderosa para motivarlos a realizar las tareas diarias, sin sacrificar la felicidad del proceso, en este capítulo compartiremos como el autor pasó de vivir estresado y persiguiendo metas sin sentido, a crear un vida con significado propósito y logrando cuadruplicar sus ingresos en 8 meses , No te lo pierdas!! Síguenos: https://www.instagram.com/_psicologiadellogro/ --- Send in a voice message: https://anchor.fm/dario-rosas/message

Juwan Gary is N6' 6" F transfer from AlabamaAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Federal Inland Revenue Service has generated a record N6.4 trillion as revenue in 2021, the highest in its history. This year's revenue collection exceeded that of 2019 when the agency raked in N5.3 trillion under the administration of Babatunde Fowler. Spokesman to FIRS Chairman, Oluwatobi Wojuola, says that despite the limitations faced in 2020 and 2021, the service achieved over 100 per cent of its collection target. Wojuola stated that in line with the law, 2021 income tax revenue was a function of the outcome of business activities in 2020.

The earliest abduction cases, like those of Betty and Barney Hill and Antônio Villas Boas, were strange and new. Cases in which people were kidnapped by alien beings were rare. So rare, in fact, that they had never appeared in print before. But when they did cases started to emerge, slowly, into the ufological psyche.  One of the earliest cases involves the abduction of a Brazilian soldier, José Antônio da Silva, who was kidnapped by short hairy humanoids, taken to a strange room, made to consume a strange liquid, and was perhaps involved in an intergalactic arms deal? Brian Hastie from Double Density and The Order of Podcasters joins me to discuss one of the most fascinating and earliest alien abduction cases. Sources: "Forty Eight Hours Inside a Flying Saucer" by Gordon Creighton, Flying Saucer Review 1971 V17 N6  "Abduction at Bebedouro" by Húlvio Brant Alexio, Flying Saucer Review 1973 V 19 N6  "Bebedouro II: The Little Men Return for the Soldier" by Húlvio Brant Alexio, Flying Saucer Review 1975 V 21 N 3-4  Theme Song: "Ufo" by Floats, available on Soundcloud, iTunes and Spotify Logo is by The Great Desdymona Check out my links here.

Irregular Show - Men are Scum; Women are...Scam? ft. N6 by The Irregular Show Podcast

Es la pérdida espontánea de un feto antes de la semana 20 del embarazo. En Clínica Abierta, el Dr. Elmo Rodríguez, doctor en medicina, ofrece sabios consejos de salud, así como efectivos remedios basados en la medicina natural. Su co-animadora, Lorraine Vázquez, mantiene el ameno curso del programa con sus interesantes preguntas y comentarios.

Aging-US published a Special Collection on Eye Disease which included "ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma" which reported that ALKBH5, a key component of the N6-methyladenosine (m6A) methyltransferase complex, was significantly elevated in uveal melanoma cell lines and inhibited tumor growth in vitro and in vivo. EP300-induced H3K27 acetylation activation activated increased ALkbH5 expression and inhibited UM cell proliferation, migration, invasion and increased apoptosis in vitro. Besides, it may promote UM metastasis by inducing epithelial-to-mesenchymal transition (EMT) via demethylation of FOXM1 mRNA, which increases its expression and stability. It is a potential prognostic biomarker and therapeutic target in UM. Dr. Jingxiang Zhong and Dr. Lian Liu said, "Uveal melanoma (UM), which originates from melanocytes, is the most common primary intraocular malignancy in adults." Up to 50% of patients with primary malignant meningitis (UM) will develop metastatic disease. The most common sites of UM metastasis are the liver (60.5%), lungs (24.4%), skin/soft tissue (10.9%), and bone (8.4%). Unfortunately, the 1-year survival rate of UM patients with metastases is only 15% [5]. There is a pressing need to find useful prognostic biomarkers and therapeutic targets for this disease. Alkhabh5 overexpression of ALKBH5 promotes EMT of UM by upregulating FOXM1 expression via demethylating the m6A modification and further increasing the stability of FOXm1 mRNA. The Zhong/Liu Research Team concluded in their Aging-US Research Output, "we demonstrate that ALKBH5, which is positively regulated by epigenetic modifications of H3K27 acetylation, promotes tumor progression by inducing tumor EMT and increasing FOXM1 expression via m6A demethylation (Figure 7). Therefore, ALKBH5 is a potential target of UM molecular therapy." Full Text - https://www.aging-us.com/article/202371/text Correspondence to: Jingxiang Zhong email: tzjx@jnu.edu.cn and Lian Liu email: lianliu@jnu.edu.cn Keywords: uveal melanoma, ALKBH5, FOXM1, senescence-associated T cells, m6A demethylation About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

On this episode of the Dailies, the following stories were brought to you from the major newspapers to keep you abreast of the latest happening across the nation, and some of these these stories incisively treated by our seasoned analysts: · Subsidy: Nigerians to spend N6.7tn on fuel in 2022, NLC, Senate fault N5,000 palliative · 5G: Nigerians should expect smart cities, self-driving car facilities, says NCC · Vandalism: Oil sector GDP contribution drops by N270bn in nine months · Sanwo-Olu presents N1.388trn humongous budget, restates special status for Lagos · OOU, TASUED other varsities top list of illegal admission · Minister: source of funding for transport grants not yet determined · 6 states' NECO results withheld over 3-year exam fees debt · JAMB uncovers 706,189 illegal admissions by varsities, others · NLC rejects planned petrol price increase · Secret employment ongoing in federal civil service, Senate alleges These and more...

On this episode of our Yoruba news, the following stories were dished: · Secondary School Students Attack DPO In Ogun · FG Earmarks Over N190bn For 2022 Census · Kanu's detention: MASSOB tackles CNG's call for ex-minister, Igbo leaders' arrest · NLC, TUC reject N340 planned petrol price · NBA, SANs say Lai's response on #EndSARS report premature · Subsidy: Nigerians to spend N6.7tn on fuel in 2022, NLC, Senate fault N5,000 palliative · Stop Obiano from leaving Nigeria after tenure, EFCC tells Immigration · Sanwo-Olu presents N1.388trn humongous budget, restates special status for Lagos · DSS's planned extradition negates Buhari's political solution- Afenifere · Uzodinma returns lands forcibly taken from owners by Okorocha's govt

On this episode of So Kan Wa, our seasoned analysts took their time to dissect some of the news stories from the dailies. Among the treated stories were: · Subsidy: Nigerians to spend N6.7tn on fuel in 2022, NLC, Senate fault N5,000 palliative · NLC, TUC reject N340 planned petrol price · Plan To Increase Petrol Pump Price To N350 Will Plunge Nigeria Into Crisis ― Afenifere

On this episode of the Dailies, the following stories were brought to you from the major newspapers to keep you abreast of the latest happening across the nation, and some of these these stories incisively treated by our seasoned analyst: · INEC awaits president's action on electoral acts · APC Governors meet on direct primaries · ACF chieftain urges Buhari to sign bill. · Malami, DSS: El-Zakzaky's passport not in our custody · Nigerians stranded abroad over expired passport. · N19.3bn saga: Kogi alleges EFCC doing hatchet job, issues 48-hour ultimatum · IPOB: Carry out your normal activities, Ohanaeze tells transporters, others · Lagos approves 135 private hospitals for COVID-19 vaccination, okays N6,000 fee · Oyo predicts influx of investors, readies IPP December 2022 · OAU student: Family demands participation as autopsy holds today These and more stories…

To discuss the unswerving low budgetary allocations to the health sector by the federal government which have contributed to the challenges facing the sector. A breakdown of the budget in the past three years (2019-2021) shows that N6,534 was budgeted for each citizen. Is the N2,178 allocated to each citizen in a year based on the projected 2021 proposed population of the country enough to treat even malaria which is the most endemic in the country?

The Federal Government says it allocated N6trn to the Niger Delta Development Commission between 2001 and 2019. Minister of Justice and Attorney General of the Federation, Abubakar Malami says It is on record that between 2001 and 2019, the Federal Government allocated the total sum of approximately N6 trillion to the Niger Delta Development Commission.He says the figure is an indication that the Federal Government has allocated a good amount of funds to the development of Nigeria's oil-bearing region.He, however, expressed concern over uncompleted and some unverified projects in the Niger Delta despite the allocations.

The Federal Government says it allocated N6trn to the Niger Delta Development Commission between 2001 and 2019. Minister of Justice and Attorney General of the Federation, Abubakar Malami says It is on record that between 2001 and 2019, the Federal Government allocated the total sum of approximately N6 trillion to the Niger Delta Development Commission.He says the figure is an indication that the Federal Government has allocated a good amount of funds to the development of Nigeria's oil-bearing region.He, however, expressed concern over uncompleted and some unverified projects in the Niger Delta despite the allocations.

The Federal Government says it allocated N6trn to the Niger Delta Development Commission between 2001 and 2019. Minister of Justice and Attorney General of the Federation, Abubakar Malami says It is on record that between 2001 and 2019, the Federal Government allocated the total sum of approximately N6 trillion to the Niger Delta Development Commission.He says the figure is an indication that the Federal Government has allocated a good amount of funds to the development of Nigeria's oil-bearing region.He, however, expressed concern over uncompleted and some unverified projects in the Niger Delta despite the allocations.

Todd meets with Sammi, a friend and mother of a young man with autism, to talk about the mixed feelings that come with her son's transition to adulthood for s1. E6. N6. of the Otherness Podcast titled Part Boy, Part Man. A Kind of Transition to Autism Adulthood.Through the lens of a mother, Todd reflects on the fear and growth that come through the development from childhood to adulthood for a young man on the spectrum.As Todd was developing the Otherness Podcast, he reached out to Sammi, a friend and mother of one of his former patients. Sammi was intrigued by the first episodes and felt that the voice of those who spoke through the podcast resonated with her. Todd was also curious about how her son, Bailey, was feeling and functioning as he is now 21 and about to transition to adult services. This turned into a discussion that peels back some of the initial feelings of anxiety around “growing up” and finds richness in the acknowledgement that Bailey is not fully an adult despite the term “adult transition”. She describes how this transition is as much about missing what a wonderful community his school has been for him throughout his life, as it is about going into something new. Sammi is touring different day programs, wants Bailey to be involved in the work community, and wants him to have a sense of happiness and self. She shares her pain while seeing Bailey's non-autistic peers obtain goals that he may want, but may never have. These include driving, graduating high school and college, and forming romantic relationships. “There are always transitions for the neurotypical population that sometimes make the autism transitions a little painful.”Despite her heavy involvement in the autism community as an advocate and fundraiser, she feels there is so much to explore for Bailey in this new phase of his life. Some of these plans may work out, and some may not. However, Sammi is open to the new experience and hopes Bailey is too.The Otherness Podcast is exploring and engaging autism through experienced stories with Dr. Todd Peter Levine and is available on most places and sites where you like to listen to podcasts.Part Boy, Part Man. A Kind of Transition to Autism Adulthood is s1. E6. N6. of the Otherness Podcast.*******The Otherness Podcast is exploring and engaging autism through experienced stories with Dr. Todd Peter Levine and is available on most places and sites where you like to listen to podcasts.*******Opening Theme Song Music Credits“Otherness Podcast Intro Theme Song and Music” by Nicholas BurlingCopyright 2021 Late Leopard Publishing/Nick Burling (ASCAP)Administered by Late Leopard Publishing (ASCAP)*******Closing Theme Song Music Credits“Otherness Podcast Outro Theme Song and Music” by Nicholas BurlingCopyright 2021 Late Leopard Publishing (ASCAP)Administered by late Leopard Publishing (ASCAP)*******Part Boy, Part Man. A Kind of Transition to Autism Adulthood

Text by Kazuko Morita , Miduho Morita (2020/07/12)　　Translation and Narration by Manosha Rajapaksha N1) ජපානයේ ගිම්හාන ඍතුවේදී පරිසර උෂ්ණත්වයත් ආර්ද්‍රතාවයත් ඉහළ මට්ටමක පවතින නිසා “ශරීර උෂ්ණත්වය ඉහළ යාම"ට ලක්වන පුද්ගලයින් සංඛ්‍යාව වැඩි වේ. කොරෝනා වෛරසයෙන් වැළකීම සඳහා මුඛ ආවරණ පළඳින පුද්ගලයින් මෙන්ම මුහුණු ආවරණ පළඳින පුද්ගලයින් ද බහුලව සිටියි. උණුසුම් ගිම්හානය ගතකරන ආකාරය පිළිබඳව පෙර වසරවලට සාපේක්‍ෂව මෙම වසරේදී විවිධ උපක්‍රම භාවිතා කිරීම අත්‍යවශ්‍ය වේ. N2) ජපානයේ ගිම්හාන ඍතුව, ජූනි මාසයේ සිට අගෝස්තු මාසය දක්වා පවතියි. අධික උෂ්ණත්වය සහ ආර්ද්‍රතාවය හේතුවෙන් දෛනික ජීවිතය ගත කිරීමට අපහසුවීමත් විශේෂ ලක්ෂණයකි. තවද ගිම්හාන ඍතුවේ දී , සාමාන්‍ය උෂ්ණත්වය සෑම වසරකම ක්‍රම ක්‍රමයෙන් ඉහළ යන අතර, මෙම වසරේ ගිම්හාන ඍතුවේදිත් වඩාත් උණුසුම් වී තිබේ. N3) සෑම වසරකම මිනිසුන් 50,000කට අධික පිරිසකට “ශරීර උෂ්ණත්වය ඉහළ යාම” හේතුවෙන් , ගිලන්රථවලින් රෝහල් කරා ගෙන යනු ලබයි. එමෙන්ම, තරුණ පුද්ගලයින් මෙන්ම නිරෝගී පුද්ගලයින් ද මෙම “ශරීර උෂ්ණත්වය ඉහළ යාම”ට ලක්වනු ලබයි. N4) පරිසර උෂ්ණත්වය ඉහළ යන විට, ශරීර උෂ්ණත්වය ද ඉහළ යනු ලැබේ. ශරීරයේ උෂ්ණත්වය පාලනය කිරීමට දහඩිය පිටකළද, ආර්ද්‍රතාවය ඉහළ යන විට දහඩිය ශරීරයෙන් වාෂ්පීකරණය කිරීමට අපහසු වන නිසා, උෂ්ණත්වය ශරීරය තුළ එකතුවීම හේතුවෙන් ශාරීරික උෂ්ණත්වය ඉහළ යනු ලබයි. පරිසර උෂ්ණත්වයට අනුව ශාරීරික උෂ්ණත්වය ද හොඳින් පවත්වාගෙන යාමට වගබලාගත යුතුය. N5)ඔබට මෙවැනි ශාරීරික ලක්ෂණ පවතිනවාද? ・ක්ලාන්ත ගතිය සමග හිසරදය ・ශරීරයට අප්‍රාණික බව සහ පිළිකුල් සහගත බවක් දැනීම ・ශාරීරික උෂ්ණත්වය ඉහළ යන අතර සම රත්පැහැ ගැන්වීම ・ඇඟපත වේදනාවන් සහ මස්පිඩු වේදනාවන් ඇතිවීම ・දැඩි ලෙස දහඩිය දැමීම ・ජලය පානය කිරීමට නොහැකි වීම ・ඇවිදීමට අපහසු වීම හෝ වචන පිට නොවීම ・මානසික නිරවුල්බාවයක් නොමැතිවීම N6) සූර්යාලෝකයේ වෙනස දැඩිවන අතර, පරිසර උෂ්ණත්වය සහ ආර්ද්‍රතාවය ඉහළ යත්ම සුළං හැමීම නොවන අවස්ථාවවලදී විශේෂයෙන් සැලකිලිමත් වීම අත්‍යවශ්‍ය වේ. කාමරය තුල දී වුවත් ශාරීරික උෂ්ණත්වය ඉහළ යාම සිදු වේ. එමෙන්ම ශරීරය චලනය කිරීම, වැඩවල නිරත වීම , නිදාගැනීම ආදී අවස්ථාවල දී ද ශාරීරික උෂ්ණත්වය ඉහළ යාම සිදු වේ. N7)ස්වල්ප වශයෙන් හෝ විවේක ගෙන ශරීරය සිසිල් කරගැනීමට අවධානය යොමුකර යුතුය. හිරු බැස යන විට, හිරු එළියට නිරාවරණය වීමෙන් වැළකී සිටීම ද ශක්තිජනක පාන වර්ග පානය කිරීමට ද කාරුණික වන්න. මානසික නිරවුල්බාවයක් නොමැති වීමත්, කතාබහ කිරීම අපහසු අවස්ථාවලත් ශාරීරික උෂ්ණත්වය ඉහළ යාම අනතුරුදායක වේ. මෙවන් අවස්ථාවලදී රෝහල කරා රැගෙන යාමට ගිලන්රථයකට දැන්වීමට වගබලාගත යුතු වේ . තනිව ජීවත්වන අය ද , මහළු අය ද, කුඩා ළමුන් ද තමන් පිළිබඳව විමසිලිමත් නොවන අවස්ථාවල , ශාරීරික උෂ්ණත්වය ඉහළ යාම සිදුවිය හැකිය. එම නිසාම, පවුලේ අය සහ මිතුරන් එකිනෙකා සමග සැලකිලිමත්ව කටයුතුවල නිරත විය යුතුය. Source: 厚労省　熱中症予防行動 https://www.city.kimitsu.lg.jp/uploaded/attachment/22256.pdf ケアネット(Care net) 「withコロナの夏に5つの提言／日本感染症学会・日本救急医学会・日本臨床救急医学会・日本呼吸器学会」2020.06.11 https://www.carenet.com/news/general/carenet/50229?utm_source=m15&utm_medium=email&utm_campaign=2020061201「新型コロナウイルス感染症の流行を踏まえた熱中症予防に関する提言」 『新しい生活様式』下における熱中症予防に関する学術団体からのコンセンサス・ステートメント2020.06.01 http://www.kansensho.or.jp/uploads/files/news/gakkai/covid19_teigen_2006.pdf 「熱中症とは」ドクターズ・ファイル https://doctorsfile.jp/medication/233/ 株式会社タニタ　熱中症の原因と対策 https://www.tanita.co.jp/health/exercise/heatstroke/ 気象庁　日本の季節平均気温 https://www.data.jma.go.jp/cpdinfo/temp/sum_jpn.html

Jon and Jeff talk with Matt Rizzetta, President and CEO of North 6th Agency, Inc. (N6A), about how to grow your brand post COVID. Matt Rizzetta is the President and CEO of North 6th Agency, Inc. (N6A), a leading brand communications agency based in New York City. Under Rizzetta’s leadership, N6A has been ranked as the #1 fastest-growing agency in the United States in its revenue category by O’Dwyers. N6A has been awarded several prestigious industry recognitions, including New York Observer Power Agency List, Summit International Award, PR News Marketing and PR Leader of the Year, and has been selected as one of the “coolest spaces at the hottest PR firms” by the New York Observer. Rizzetta has been instrumental in developing N6A’s internal and external KPI measurement system, and has created a culture at N6A that has been lauded as one of the most rewarding, collaborative and unique in the agency landscape. Among the signature programs that Rizzetta has developed at N6A are the N6A 6PA Performance Ranking System, “N6-get-Away” vacation competition, “N6A Bucket List Weekend” competition, “N6-leg-Acy” PTO package, “N6A Chairman’s Pick” award, and many more. Rizzetta serves as a board member at Iona College, and currently resides in Westchester County, NY with his wife and three daughters.   Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon’s Book: The Think Big Movement: Grow your business big. Very Big!   Connect with Matt Rizzetta: Twitter: @North6thAgency Website:  www.n6a.com  www.competeandcare.com Email:  mrizetta@n6a.com  Get Matt's Book: https://www.amazon.com/Embrace-Pace-Exhilarating-Lessons-Entrepreneurship/dp/109830196X/ref=sr_1_2?dchild=1&keywords=Matt+Rizzetta&qid=1585006076&sr=8-2 

In 1938, Italian physicist Ettore Majorana vanished after taking a sudden sea journey. At first it was feared that he'd ended his life, but the perplexing circumstances left the truth uncertain. In today's show we'll review the facts of Majorana's disappearance, its meaning for physics, and a surprising modern postscript. We'll also dither over pronunciation and puzzle over why it will take three days to catch a murderer. Intro: By design, no building in Washington, D.C., is taller than the Washington Monument. The Vienna Vegetable Orchestra plays instruments made of fresh vegetables. Sources for our feature on Ettore Majorana: Erasmo Recami, The Majorana Case: Letters, Documents, Testimonies, 2019. Salvatore Esposito, Ettore Majorana: Unveiled Genius and Endless Mysteries, 2017. Salvatore Esposito, The Physics of Ettore Majorana, 2015. Salvatore Esposito et al., eds., Ettore Majorana: Notes on Theoretical Physics, 2013. Salvatore Esposito, Erasmo Recami, and Alwyn Van der Merwe, eds., Ettore Majorana: Unpublished Research Notes on Theoretical Physics, 2008. Francesco Guerra and Nadia Robotti, "Biographical Notes on Ettore Majorana," in Luisa Cifarelli, ed., Scientific Papers of Ettore Majorana, 2020. Mark Buchanan, "In Search of Majorana," Nature Physics 11:3 (March 2015), 206. Michael Brooks, "The Vanishing Particle Physicist," New Statesman 143:5233 (Oct. 24, 2014), 18-19. Francesco Guerra and Nadia Robotti, "The Disappearance and Death of Ettore Majorana," Physics in Perspective 15:2 (June 2013), 160-177. Salvatore Esposito, "The Disappearance of Ettore Majorana: An Analytic Examination," Contemporary Physics 51:3 (2010), 193-209. Ennio Arimondo, Charles W. Clark, and William C. Martin, "Colloquium: Ettore Majorana and the Birth of Autoionization," Reviews of Modern Physics 82:3 (2010), 1947. Graham Farmelo, "A Brilliant Darkness: The Extraordinary Life and Mysterious Disappearance of Ettore Majorana, the Troubled Genius of the Nuclear Age," Times Higher Education, Feb. 18, 2010. Frank Close, "Physics Mystery Peppered With Profanity," Nature 463:7277 (Jan. 7, 2010), 33. Joseph Francese, "Leonardo Sciascia and The Disappearance of Majorana," Journal of Modern Italian Studies 15:5 (2010), 715-733. Frank Wilczek, "Majorana Returns," Nature Physics 5:9 (2009), 614-618. Barry R. Holstein, "The Mysterious Disappearance of Ettore Majorana," Journal of Physics: Conference Series 173, Carolina International Symposium on Neutrino Physics, May 15–17, 2008. Joseph Farrell, "The Ethics of Science: Leonardo Sciascia and the Majorana Case," Modern Language Review 102:4 (October 2007), 1021-1034. Zeeya Merali, "The Man Who Was Both Alive and Dead," New Scientist 191:2563 (Aug. 5, 2006), 15. Erasmo Recami, "The Scientific Work of Ettore Majorana: An Introduction," Electronic Journal of Theoretical Physics 3:10 (April 2006), 1-10. Ettore Majorana and Luciano Maiani, "A Symmetric Theory of Electrons and Positrons," Ettore Majorana Scientific Papers, 2006. R. Mignani, E. Recami, and M. Baldo, "About a Dirac-Like Equation for the Photon According to Ettore Majorana," Lettere al Nuovo Cimento 11:12 (April 1974), 568-572. Angelo Paratico, "Science Focus: Italy Closes Case on Physician's Mysterious Disappearance," South China Morning Post, Feb. 15, 2015. Antonino Zichichi, "Ettore Majorana: Genius and Mystery," CERN Courier 46 (2006), N6. Peter Hebblethwaite, "Saints for Our Time," Guardian, April 17, 1987. Walter Sullivan, "Finding on Radioactivity May Upset Physics Law," New York Times, Jan. 14, 1987. Nino Lo Bello, "Is Missing Atomic Scientist Working for the Russians?" [Cedar Rapids, Iowa] Gazette, May 3, 1959. Listener mail: "Farmers Project Is Right on Time," New Zealand Herald, Feb. 6, 2012. "Farmers Opens New Napier Store," Scoop, June 6, 2013. Megan Garber, "The State of Wyoming Has 2 Escalators," Atlantic, July 17, 2013. Brandon Specktor, "Believe It or Not, This State Only Has Two Escalators -- Here's Why," Reader's Digest, Sept. 8, 2017. Audie Cornish and Melissa Block, "Where Are All of Wyomings Escalators?" NPR, July 18, 2013. Natasha Frost, "Spiral Escalators Look Cool, But Do They Make Sense?" Atlas Obscura, July 5, 2017. "Spiral Escalator," Elevatorpedia (accesssed April 17, 2021). "Aussie," Wikipedia (accessed April 16, 2021). "Sir George Cockburn, 10th Baronet," Wikipedia (accessed April 14, 2021). "Naming Cockburn," City of Cockburn (accessed April 14, 2021). This week's lateral thinking puzzle is taken from Anges Rogers' 1953 book How Come?: A Book of Riddles, sent to us by listener Jon Jerome. You can listen using the player above, download this episode directly, or subscribe on Google Podcasts, on Apple Podcasts, or via the RSS feed at https://futilitycloset.libsyn.com/rss. Please consider becoming a patron of Futility Closet -- you can choose the amount you want to pledge, and we've set up some rewards to help thank you for your support. You can also make a one-time donation on the Support Us page of the Futility Closet website. Many thanks to Doug Ross for the music in this episode. If you have any questions or comments you can reach us at podcast@futilitycloset.com. Thanks for listening!

- La police verbalise les visiteurs au Bois de Hal (Braine l'Alleud) - Piétons et cyclistes autorisés dans le Bois du Hal du côté de Braine-le-Chateau - Aldi et Trafic arrivent le long de la N6 à Braine le Comte - Retour à la normale à l'administration communale de Pont-à-Celles

The Central Bank of Nigeria has imposed a 6.98 naira service charge on Nigerians for all USSD transactions.A statement jointly signed by the apex bank and the Nigerian Communications Commission says Customers will pay a flat fee of N6.98 per transaction every time they use USSD services from March 16.The deal was part of an agreement reached with banks following a disagreement between banks and telecom firms over USSD and other text message transaction requests.The statement partly read that the approach is transparent and will ensure the amount remains the same, regardless of the number of sessions per transaction.The CBN noted that the charges were part of the agreements after banks and telecommunication operators met on Monday to discuss the ₦42bn debt owed mobile operators by banks.

The Federal Government has approved N6.45 billion for the setting up of gas plants in 38 locations nationwide in a bid to enhance the treatment of COVID-19 patients who need oxygen.The Minister of Finance, Budget and National Planning, Zainab Ahmed while briefing the NEC on the release of the funds, said the President approved the release of the funds for the production of oxygen, necessitated by the increased number of patients who need oxygen due to the surge in Covid-19 infections in the country.

Ejike dreams of becoming a governor. He arrived in Lagos in January 2020, leaving his parents in Ebonyi state. His brother promised to send him to school. But he’s in Lagos, selling CDs in traffic- just like his brother. Making between N6,000-N10,000 a day, Ejike supports his brother’s family of four. Ejike wants to become a governor in Lagos state. He says his brother promised to send him to school next year. He’s told he can’t go to school this year because of COVID 19. Ejike is 14 years old. Farouk is 17 years old. His mum sells herbs in Ibadan while his dad is an Alfa (Islamic scholar). He travelled to Lagos on his own and caters to himself, calling passengers at the motor park and sometimes bearing load for money in the market in Oshodi. During the COVID19 lockdown, Farouk says he barely survived. He couldn’t make money as markets were open only temporarily and buses were not moving. He said one of the few women who came to the market fed him throughout the lockdown. --- Send in a voice message: https://anchor.fm/dnnpodcast/message

The Federal Executive Council on Wednesday approved N40 billion for the construction of road and ecological projects in different parts of the country.Minister of Works and Housing, Mr. Babatunde Fashola, said N14.528 billion was approved for the construction of Gasamu-Hamshi-Gogoram road in Yobe State. He said N991.851 million approved for the construction of a link road connecting Uneme-Tusamu-Odoga to Okpekpe in Etsako East Local Government Area of Edo State and N6.397 billion approved for the reconstruction of Mamabu-Donga road in Taraba South Local Government Area of Taraba State.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.14.382556v1?rss=1 Authors: Roy, R., Li, X., Hou, S., Fujiwara, Y., Sukegawa, M., Hong, W.-T., Oomoto, I., Ito, H., Joshi, K., Fan, R., Nagata, K.-i., Lai, K.-o., Wang, D. O. Abstract: Building and maintaining neuronal networks and cognitive functions require mRNA localization and regulated protein synthesis in neurons. RNA modification N6-methyl-adenosine (m6A) has recently been shown in axonal and synaptically localized mRNAs whose local activity is required for axon growth, synaptogenesis, and neuronal plasticity. However, no cellular pathways engaging local epitranscriptomic modulation are known to underlie these post-mitotic neuronal functions. Now we report that cytoplasmic m6A reader YTHDF1 is enriched in neurons and required for axonal, dendritic, and spine development. We show that m6A and YTHDF1 are part of a microtubule plus-end associated RNA granule that contains extensive networks of mRNAs organized by autism risk gene adenomatous polyposis coli (APC). Disrupting m6A signals by knocking down methyltransferase METTL14 or YTHDF1, or overexpressing autism or schizophrenia-associated missense mutations I311V or S399L in human METTL14, reduce expression of APC granule and tubulin, disrupt microtubule assembly and function. These results reveal a novel neuronal subcellular locus for epitranscriptomic regulation to promote post-mitotic neurodevelopment. Copy rights belong to original authors. Visit the link for more info

Jon and Jeff talk with Matt Rizzetta, President and CEO of North 6th Agency, Inc. (N6A), a leading brand communications agency based in New York City. We will be talking about how to grow your brand post COVID. Matt Rizzetta is the President and CEO of North 6th Agency, Inc. (N6A), a leading brand communications agency based in New York City. Under Rizzetta’s leadership, N6A has been ranked as the #1 fastest-growing agency in the United States in its revenue category by O’Dwyers. N6A has been awarded several prestigious industry recognitions, including the New York Observer Power Agency List, Summit International Award, PR News Marketing, and PR Leader of the Year, and has been selected as one of the “coolest spaces at the hottest PR firms” by the New York Observer. Rizzetta has been instrumental in developing N6A’s internal and external KPI measurement system and has created a culture at N6A that has been lauded as one of the most rewarding, collaborative, and unique in the agency landscape. Among the signature programs that Rizzetta has developed at N6A are the N6A 6PA Performance Ranking System, the “N6-get-Away” vacation competition, “N6A Bucket List Weekend” competition, “N6-leg-Acy” PTO package, “N6A Chairman’s Pick” award, and many more. Rizzetta serves as a board member at Iona College and currently resides in Westchester County, NY with his wife and three daughters. Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/ LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon’s Book: The Think Big Movement: Grow your business big. Very Big!   Connect with Matt Rizzetta: Twitter: @North6thAgency Website:  www.n6a.com  www.competeandcare.com Email:  mrizetta@n6a.com  Book: https://www.amazon.com/Embrace-Pace-Exhilarating-Lessons-Entrepreneurship/dp/109830196X/ref=sr_1_2?dchild=1&keywords=Matt+Rizzetta&qid=1585006076&sr=8-2

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.311803v1?rss=1 Authors: Moroz-Omori, E. V., Huang, D., Bedi, R. K., Cheriyamkunnel, S. J., Bochenkova, E., Dolbois, A., Rzeczkowski, M. D., Wiedmer, L., Sledz, P., Caflisch, A. Abstract: The methylase METTL3 is the writer enzyme of the N6-methyladenosine (m6A) modification of RNA. Using a structure-based drug discovery approach, we identified a METTL3 inhibitor (UZH1a) with potency in a biochemical assay of 280 nM, while its enantiomer UZH1b is 100 times less active. The crystal structure of the complex of METTL3 with UZH1a illustrates the interactions that make it selective against protein methyltransferases. We observed a dose-dependent reduction in m6A methylation level of mRNA in several cell lines treated with UZH1a already after 16 h of exposure, as determined by triple-quadrupole LC mass spectrometry, while its enantiomer UZH1b was essentially inactive at concentrations up to 100 M. Interestingly, the kinetics of m6A level reduction in mRNAs followed a first-order reaction model, with a half-decay time {tau} of 1.8 h and a maximum m6A inhibition level of 70%, which is in line with the previously observed shorter half-life of m6A-modified mRNAs. Notably, treatment with the compounds did not alter cellular METTL3 levels, ruling out indirect effects on m6A levels. The effect of the m6A level depletion by UZH1a directly translated into growth inhibition of MOLM-13 leukemia cells, under short-term and long-term culture. Incubation of the MOLM-13 cells with UZH1a, but not with UZH1b, resulted in increased cell apoptosis and cell cycle arrest already after 16 h of incubation. Interestingly, other cell lines sensitive to METTL3 level (U2Os, HEK293T) did not reveal statistically significant differences between UZH1a and UZH1b in a cell viability assay, confirming that the degree of reliance on m6A signalling for survival can vary between cancers/cell types. Copy rights belong to original authors. Visit the link for more info

Jochen Krisch und Marcel Weiß ziehen in den neuesten Exchanges Bilanz und schauen auf die turbulente Börsenzeit von Rocket Internet zurück, sprechen über die Errungenschaften des Berliner Inkubators und die Versäumnisse, die die Wirtschaftsregion Europa letztlich um ein wichtiges Puzzleteil gebracht haben. Werbepartner: * Unzer: Euer Partner für superflexible Bezahl-Lösungen online und am POS. Unzer. Euer Payment. https://www.unzer.com/

The National Bureau of Statistics, in its report released on Wednesday stated that the total value of transactions through electronic payment channels recorded in the second quarter of 2020 stood at N263.78 trillion with a transaction volume of 2,160,436,659. The report was titled Selected Banking Sector Data: Sectorial Breakdown of Credit, e-Payment Channels and Staff Strength (Q2 2020)’. The report stated that online transfer transactions dominated electronic payments with N72.25 trillion with 1,317,621,686 in volume of transactions. The value of cheque transactions stood at N2.29 trillion while NEFT transfers accounted for N59.55 trillion. Transactions via Automated Teller Machines (ATMs) amounted to N37.44 trillion while Point of Sale (PoS) transactions stood at N999.91 billion. The NBS said mobile app transfers amounted to N6.92 trillion, while USSD transfers totaled N1.04 trillion. --- This episode is sponsored by · Afrolit Podcast: Hosted by Ekua PM, Afrolit shares the stories of multi-faceted Africans one episode at a time. https://open.spotify.com/show/2nJxiiYRyfMQlDEXXpzlZS?si=mmgODX3NQ-yfQvR0JRH-WA Support this podcast: https://anchor.fm/newscast-africa/support

The latest data from Nigeria’s statistics agency shows that the demand for goods and services from China is still on the high as the Asian country tops the list of import trading partners by 31.41% in the second quarter of 2020. This is despite the sharp fall in the value of the country’s total trade to N6.24 billion, representing 27.30% in Q2, against the 27.46% level recorded in the corresponding quarter, and 27.46% year-on-year. According to the National Bureau of Statistics Foreign Trade in Goods Statistics released on Wednesday, the value of total imports dropped by 10.69% in the quarter in review, against the level recorded in Q1, but increased by 0.39% year-on-year. --- This episode is sponsored by · Afrolit Podcast: Hosted by Ekua PM, Afrolit shares the stories of multi-faceted Africans one episode at a time. https://open.spotify.com/show/2nJxiiYRyfMQlDEXXpzlZS?si=mmgODX3NQ-yfQvR0JRH-WA Support this podcast: https://anchor.fm/newscast-africa/support

In this episode of the Epigenetics Podcast, we caught up with Dr. Chuan He, John T. Wilson Distinguished Service Professor at the University of Chicago, to talk about his work on the influence of dynamic RNA methylation on gene expression. More than 150 structurally distinct post-transcriptional modifications of RNA have been identified at thousands of sites in cellular RNA molecules. Some RNA modifications are dynamic and may have critical regulatory roles analogous to modifications of protein and DNA. Understanding the scope and mechanisms of dynamic RNA modifications thus represents an emerging research frontier in biology and medicine. The internal N6-methyladenosine (m6A) modification in messenger RNA (mRNA) is one of the most abundant RNA modifications in eukaryotes. On average, this RNA base modification is present in approximately 3 sites in every mammalian mRNA molecule. The m6A modification has been shown to be critically important for cellular differentiation, animal development, and a range of biological signaling and stress responses. In 2011, Chuan He's lab reported that m6A in mammalian mRNA can be oxidatively demethylated in vitro and inside cells by the enzyme FTO (a fat mass and obesity-associated protein), a major obesity factor This discovery identified FTO as the first known RNA demethylase. Chuan He’s lab also subsequently identified ALKBH5 as the second RNA demethylase that controls mammalian spermatogenesis. More recent work in the He lab has focused on characterization of the YTH family proteins as the “reader” proteins that detect and bind methylated RNAs in mammalian cells to regulate their stability and translation. Functional characterizations revealed that YTHDF2 regulates cytoplasmic localization and mediates the decay of methylated mRNA, YTHDF1 promotes translation of methylated mRNA by facilitating translation initiation, and other methylated RNA readers also contribute to the regulation of mRNA storage, transport, and cellular localization.   Research in the He lab also identified a core protein complex comprised of two subunits: METTL3 and METTL14, and an accessory factor WTAP, which mediates cellular m6A RNA methylation. Cellular RNA methylation levels can have profound impacts on normal cellular differentiation and cancer cell proliferation. Their current work focuses on how the methylation selectivity is achieved. In this interview, we discuss the story on how the He lab discovered the members of the family of proteins that read, write, and erase RNA modifications and the mechanisms of how those RNA modifications act in the field of epigenetics.   References   Guifang Jia, Cai-Guang Yang, … Chuan He (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO (FEBS letters) DOI: 10.1016/j.febslet.2008.08.019 Guifang Jia, Ye Fu, … Chuan He (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO (Nature Chemical Biology) DOI: 10.1038/nchembio.687 Guanqun Zheng, John Arne Dahl, … Chuan He (2013) ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility (Molecular Cell) DOI: 10.1016/j.molcel.2012.10.015 Jianzhao Liu, Yanan Yue, … Chuan He (2014) A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation (Nature Chemical Biology) DOI: 10.1038/nchembio.1432   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on Linked-In Active Motif on Facebook eMail: podcast@activemotif.com

The FMDQ Holdings Plc has listed the United Capital Plc Series 1 N10.00bn Fixed Rate Bond under its N30.00bn Bond Programme in its platform. The Exchange also admitted LAPO MFB SPV Plc Series 2 N6.20bn Fixed Rate Bond under its N20.00bn Bond Issuance Programme. FMDQ said in a statement that the Nigerian debt capital market had continued to demonstrate buoyancy and resilience in the face of the pandemic. It said this had authenticated its role and increased capacity to support domestic economic growth by providing alternative capital sources as well as the much-needed liquidity to boost working capital for corporates and governments. --- This episode is sponsored by · Afrolit Podcast: Hosted by Ekua PM, Afrolit shares the stories of multi-faceted Africans one episode at a time. https://open.spotify.com/show/2nJxiiYRyfMQlDEXXpzlZS?si=mmgODX3NQ-yfQvR0JRH-WA Support this podcast: https://anchor.fm/newscast-africa/support

The Petroleum Products Pricing Regulatory Agency on Tuesday increased the ex-depot price of petrol by N6 to N138.62/litre for the month of August 2020.Oil marketers stated that based on the latest increase in ex-depot price, the pump price of Premium Motor Spirit, popularly called petrol, could be between N149/litre and N150/litre this month.The Vice President, Independent Petroleum Marketers Association of Nigeria, Abubakar Maigandi, told our correspondent that the PPPRA, however, did not tell marketers the new pump price for petrol.He said the Pump price might be announced today.Maigandi added that with the N6/litre increase in ex-depot price, the projection is that the pump price will be around N149/litre or N150/litre, based on our usual computations.”Learn more about your ad choices. Visit podcastchoices.com/adchoices

丽莎老师讲机器人之机器人3.0时代来了！欢迎收听丽莎老师讲机器人，想要孩子参加机器人竞赛、创意编程、创客竞赛的辅导，找丽莎老师！欢迎添加微信号：153 5359 2068，或搜索微信公众号：我最爱机器人。最新的《世界机器人技术》报告显示，全球工厂中有超过240万台工业机器人在运行，全球销售总额达到了165亿美元的新记录。IFR预计，从2020年到2022年，将在全球工厂安装近200万台新的工业机器人，新技术的发展将使公司能够响应不断变化的需求。可以预见的是，全球机器人步入机器人3.0时代，物联网、机器人和AI三者融合碰撞将推动前所未有的全球跨行业领域的合作未来几年，简化、协作和数字化将是机器人领域的三个关键驱动力。趋势一：机器人变得更聪明机器人的编程和安装将变得更加容易。通过数字传感器与智能软件相结合，可以采用直观的教学方法，即所谓的“演示编程”。机器人手臂要执行的任务首先由人来执行，他实际上是抓住了机器人手臂并通过手动引导机器人运动。然后通过软件将该运动轨迹转换为机械臂的数字程序。将来，机器学习工具将进一步使机器人能够通过反复试验或视频演示来学习并自我优化其运动轨迹。聪明这一需求也使得工业机器人更小、更轻、更灵活。当前，工业机器人的应用场景愈加广泛，苛刻的生产环境对机器人的体积、重量、灵活度等提出了更高的要求。与此同时，随着研发水平不断提升、工艺设计不断创新，以及新材料相继投入使用，聪明的工业机器人必然正向着小型化、轻型化、柔性化的方向发展，类人精细化操作能力不断增强。例如日本SMC致力于为机器人研制高品质的末端执行器，研发的新型汽缸体积缩小了40%以上，质量最高减轻了69%，耗气量最高减少了29%。日本爱普生首款新型折叠手臂六轴机器人N2，可在现有同级别机械臂60%的工位空间内完成灵活操作；折叠手臂六轴机器人N6采用内部走线设计，其折叠手臂可自然进入高层设备、机器、架子等狭窄空间；T3紧凑型SCARA机器人将控制器内置，避免了在设置和维护过程中进行复杂的布线，大大提高了成本效率并保持较低的总运行成本。德国费斯托（Festo）的新型全气动驱动机械臂，将刚性的“抓取”转变为柔性的“围取”，能完成灵活抓取不同大小部件的任务。趋势二：机器人与工人的协作人机协作是机器人技术的另一个重要趋势。随着机器人易用性、稳定性以及智能水平的不断提升，机器人的应用领域逐渐由搬运、焊接、装配等操作型任务向加工型任务拓展，人机协作正在成为工业机器人研发的重要方向。传统工业机器人必须远离人类，在保护围栏或者其他屏障之后，以避免人类受到伤害，这极大的限制了工业机器人的应用效果。机器人应当具备与人类协同工作的能力，现代机器人系统便能够适应快速变化的环境。机器人制造商提供的协作应用程序范围也在不断扩大。当前，共享工作区类型的应用程序是最常见的。机器人和工人彼此并存，依次完成任务。人机协作将人的认知能力与机器人的效率结合在一起，从而使人可以安全、简便的进行使用。例如，瑞士ABB的双臂人机协作机器人YuMi可与工人一起协同工作，在感知到人的触碰后，会立刻放慢速度，最终停止运动。德国库卡（KUKA）的协作机器人LBR iiwa可以以每秒10毫米或50毫米的速度抵近物体，并在遇到阻碍后立刻停止运动。优傲e-Series协作式机器人可设定机械臂保护性停止的停止时间和停止距，并内置力传感器提高精度和灵敏度，满足更多应用场景的需求。但目前更具有挑战性的是人与机器人在同一时间同时工作。很多机器人研发团队正在致力于使机器人能够进行实时响应，就像两个人工协作一样，研发团队希望他们根据环境的变化调整动作，从而实现真正的响应式协作。这些解决方案包括语音、手势和对人类动作意图的识别。借助当今的技术，人机协作对于各种规模和行业的公司都具有巨大的潜力。趋势三：机器人走向数字化工业机器人是数字化和网络化生产的核心组件。因此对于他们而言，无论制造商是哪家，能够彼此通信就显得尤为重要。由德国机械制造联合会VDMA和OPC基金会联合工作组开发的“ OPC机器人技术规范”定义了工业机器人的标准化通用接口，并使工业机器人能够连接到工业物联网。机器人的数字连接性（例如云技术）将促成新业务模式的发展。例如，机器人租赁（称为“机器人即服务”）的业务模式，将特别适用于资金、人力匮乏但想增加效益的小型企业。可以想象，随着新一代信息技术与制造业进一步加速融合，制造业愈加显著地表现出网络化、智能化、数字化的前沿发展趋势，机器人龙头企业纷纷落子工业互联网，例如，库卡机器人可与基于云技术的库卡Connect相连，实现机器人与设备的联网，实时查看和分析工业机器人的运行状态，减少系统停机时间、进行预测性维护等，并通过大数据分析持续提高生产率、质量和灵活性。ABB推出ABB Ability工业云平台，并与华为展开合作联合研发机器人端到端的数字解决方案，实现机器人远程监控、配置和大数据应用，进一步提升生产效率和节约成本。这些趋势导致，很多重点企业也必然聚焦智能工厂解决方案。当前，全球制造业格局面临重大调整，智能工厂作为工业智能化发展的重要实践模式，已经引发行业的广泛关注。例如，发那科（Fanuc）设立Fanuc Intelligent Edge Link and Drive（FIELD）平台，能实现自动化系统中的机床、机器人、周边设备及传感器的连接并进行数据分析，提高生产过程中的生产质量、效率、灵活度以及设备的可靠性。三菱电机打造的智能工厂e-F@ctory，强调“人、机器和IT协同”，可以根据数量、品种、交货期等指标的变更，灵活调整生产节奏，削减企业总成本以达到推动高端制造和提高企业价值的效果。安川电机推出i3概念，其中 i3指的是integrated（集成）、intelligent（智能）、innovative（革新），安川电机试图通过对自身机器人、电机等自动化零件组合和集成控制，实现更智能的制造解决方案。

丽莎老师讲机器人之机器人3.0时代来了！欢迎收听丽莎老师讲机器人，想要孩子参加机器人竞赛、创意编程、创客竞赛的辅导，找丽莎老师！欢迎添加微信号：153 5359 2068，或搜索微信公众号：我最爱机器人。最新的《世界机器人技术》报告显示，全球工厂中有超过240万台工业机器人在运行，全球销售总额达到了165亿美元的新记录。IFR预计，从2020年到2022年，将在全球工厂安装近200万台新的工业机器人，新技术的发展将使公司能够响应不断变化的需求。可以预见的是，全球机器人步入机器人3.0时代，物联网、机器人和AI三者融合碰撞将推动前所未有的全球跨行业领域的合作未来几年，简化、协作和数字化将是机器人领域的三个关键驱动力。趋势一：机器人变得更聪明机器人的编程和安装将变得更加容易。通过数字传感器与智能软件相结合，可以采用直观的教学方法，即所谓的“演示编程”。机器人手臂要执行的任务首先由人来执行，他实际上是抓住了机器人手臂并通过手动引导机器人运动。然后通过软件将该运动轨迹转换为机械臂的数字程序。将来，机器学习工具将进一步使机器人能够通过反复试验或视频演示来学习并自我优化其运动轨迹。聪明这一需求也使得工业机器人更小、更轻、更灵活。当前，工业机器人的应用场景愈加广泛，苛刻的生产环境对机器人的体积、重量、灵活度等提出了更高的要求。与此同时，随着研发水平不断提升、工艺设计不断创新，以及新材料相继投入使用，聪明的工业机器人必然正向着小型化、轻型化、柔性化的方向发展，类人精细化操作能力不断增强。例如日本SMC致力于为机器人研制高品质的末端执行器，研发的新型汽缸体积缩小了40%以上，质量最高减轻了69%，耗气量最高减少了29%。日本爱普生首款新型折叠手臂六轴机器人N2，可在现有同级别机械臂60%的工位空间内完成灵活操作；折叠手臂六轴机器人N6采用内部走线设计，其折叠手臂可自然进入高层设备、机器、架子等狭窄空间；T3紧凑型SCARA机器人将控制器内置，避免了在设置和维护过程中进行复杂的布线，大大提高了成本效率并保持较低的总运行成本。德国费斯托（Festo）的新型全气动驱动机械臂，将刚性的“抓取”转变为柔性的“围取”，能完成灵活抓取不同大小部件的任务。趋势二：机器人与工人的协作人机协作是机器人技术的另一个重要趋势。随着机器人易用性、稳定性以及智能水平的不断提升，机器人的应用领域逐渐由搬运、焊接、装配等操作型任务向加工型任务拓展，人机协作正在成为工业机器人研发的重要方向。传统工业机器人必须远离人类，在保护围栏或者其他屏障之后，以避免人类受到伤害，这极大的限制了工业机器人的应用效果。机器人应当具备与人类协同工作的能力，现代机器人系统便能够适应快速变化的环境。机器人制造商提供的协作应用程序范围也在不断扩大。当前，共享工作区类型的应用程序是最常见的。机器人和工人彼此并存，依次完成任务。人机协作将人的认知能力与机器人的效率结合在一起，从而使人可以安全、简便的进行使用。例如，瑞士ABB的双臂人机协作机器人YuMi可与工人一起协同工作，在感知到人的触碰后，会立刻放慢速度，最终停止运动。德国库卡（KUKA）的协作机器人LBR iiwa可以以每秒10毫米或50毫米的速度抵近物体，并在遇到阻碍后立刻停止运动。优傲e-Series协作式机器人可设定机械臂保护性停止的停止时间和停止距，并内置力传感器提高精度和灵敏度，满足更多应用场景的需求。但目前更具有挑战性的是人与机器人在同一时间同时工作。很多机器人研发团队正在致力于使机器人能够进行实时响应，就像两个人工协作一样，研发团队希望他们根据环境的变化调整动作，从而实现真正的响应式协作。这些解决方案包括语音、手势和对人类动作意图的识别。借助当今的技术，人机协作对于各种规模和行业的公司都具有巨大的潜力。趋势三：机器人走向数字化工业机器人是数字化和网络化生产的核心组件。因此对于他们而言，无论制造商是哪家，能够彼此通信就显得尤为重要。由德国机械制造联合会VDMA和OPC基金会联合工作组开发的“ OPC机器人技术规范”定义了工业机器人的标准化通用接口，并使工业机器人能够连接到工业物联网。机器人的数字连接性（例如云技术）将促成新业务模式的发展。例如，机器人租赁（称为“机器人即服务”）的业务模式，将特别适用于资金、人力匮乏但想增加效益的小型企业。可以想象，随着新一代信息技术与制造业进一步加速融合，制造业愈加显著地表现出网络化、智能化、数字化的前沿发展趋势，机器人龙头企业纷纷落子工业互联网，例如，库卡机器人可与基于云技术的库卡Connect相连，实现机器人与设备的联网，实时查看和分析工业机器人的运行状态，减少系统停机时间、进行预测性维护等，并通过大数据分析持续提高生产率、质量和灵活性。ABB推出ABB Ability工业云平台，并与华为展开合作联合研发机器人端到端的数字解决方案，实现机器人远程监控、配置和大数据应用，进一步提升生产效率和节约成本。这些趋势导致，很多重点企业也必然聚焦智能工厂解决方案。当前，全球制造业格局面临重大调整，智能工厂作为工业智能化发展的重要实践模式，已经引发行业的广泛关注。例如，发那科（Fanuc）设立Fanuc Intelligent Edge Link and Drive（FIELD）平台，能实现自动化系统中的机床、机器人、周边设备及传感器的连接并进行数据分析，提高生产过程中的生产质量、效率、灵活度以及设备的可靠性。三菱电机打造的智能工厂e-F@ctory，强调“人、机器和IT协同”，可以根据数量、品种、交货期等指标的变更，灵活调整生产节奏，削减企业总成本以达到推动高端制造和提高企业价值的效果。安川电机推出i3概念，其中 i3指的是integrated（集成）、intelligent（智能）、innovative（革新），安川电机试图通过对自身机器人、电机等自动化零件组合和集成控制，实现更智能的制造解决方案。

Davide "FoxA" Bucci is a 22 year old Canadian esports competitor and caster, and has played various games at, including Dota 2 and CS:GO. The latter is where FoxA spent much of his early competitive time. Years later, FoxA transitioned over to Rainbow Six Siege and has played at a high level ever since.

Oil marketers under the aegis of the Major Oil Marketers Association of Nigeria have said access to the dollar at N306 will enable them to resume importation of Premium Motor Spirit (petrol). The marketers also said there was an urgent need for the Federal Government, through the Petroleum Products Pricing Regulatory Agency, to increase the margins on petrol to encourage them to make more investments. According to the petrol pricing template of the PPPRA, margins for retailers and dealers are N6 and N2.36 per litre while transporters’ allowance is N3.36 per litre. --- Support this podcast: https://anchor.fm/newscast-africa/support Learn more about your ad choices. Visit megaphone.fm/adchoices

O Timbucast #82 traz o Resumão. Renato Barros, Clauber Santana e Hathos Rildo falam sobre a estreia do Náutico na Copinha, a falha lamentável na improvisação da camisa 21 da equipe, os questionamentos em torno da N6, além de temas como a contratação de Halls, a luta na justiça pela permanência de Odilavio, a novela Kieza e a montagem do time para os amistosos dessa semana. Ouça!

Forte Oil Plc will be getting a new name very soon. This is following the shareholders’ resolution to change the name of the oil company to Ardova Plc. The company made this disclosure in a notification sent to the Nigerian Stock Exchange (NSE), where it announced its forthcoming Extraordinary General Meeting (EGM), scheduled to hold on Tuesday, December 17, 2019. The Directors of the company were empowered to draw up, sign documents and appoint advisers regarding the matter where necessary. They were also expected to comply with the directives of regulatory authorities to make the name change possible. In addition, the shareholders intend to close the Register of Members and transfer of Books of the Company from 6th December 2019 to 15th December 2019 for the purpose of attending the meeting. Revenue: Forte Oil generated N123.54 billion in revenue as of the end of the nine-month period of 2019 compared to N94.81 billion in revenue as of September 2018. This represented a 30.3% increase.Profit Before Tax: As at the end of the third quarter of September 2019, Forte Oil recorded N6.53 billion as profit before tax, up from N645.88 million recorded as at the end of the third quarter of September 2018, representing an increase of 912%.Profit After Tax: The oil firm recorded a profit of N5.25 billion for the nine-month period of 2019, compared to N348.73 million recorded at the end of the nine months period for 2018 which represents a whopping 1408% increase in profit after tax. --- Support this podcast: https://anchor.fm/newscast-africa/support Learn more about your ad choices. Visit megaphone.fm/adchoices

Graciela Lorca studies genetic systems to find positive and negative microbial interactions that lead to disease. She talks about her discovery of chemical inhibitors for the citrus greening disease bacterium, Liberibacter asiaticus,and how a specific strain of Lactobacillus johnsoniimodulates the immune system and may help prevent development of diabetes in people. Subscribe (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Also available on the ASM Podcast Network app. Julie’s Biggest Takeaways Citrus greening disease, or huanglongbing, is a disease of citrus trees causing a major epidemic among citrus farmers around the world. The disease causes trees to sicken and eventually die, and is best diagnosed by PCR amplification of the bacterial DNA from the bacterium that causes the disease, Liberibacter asiaticus. Because the disease spreads through the tree at different rates, it’s important that many samples be tested for accurate diagnosis. Quarantining the disease has proved difficult, as undiagnosed roots can transmit the disease if they are used to hybridize with canopy plants. The disease becomes even harder to contain under bad weather conditions: the high winds of recent hurricanes can scatter the insect vector, the Asian citrus psyllid, leading to infection of new orchards. Although L. asiaticuscan’t be cultured, Graciela performed a screen on L. asiaticustranscription factors that were produced by E. coli. These were tested for inhibition by a chemical library, and discovered that a common treatment for gout, benzbromarone, inhibited protein activity. This discovery was confirmed using in vivoinfected plants and by expressing the gene in related bacterial species, Graciela and her team predict the protein plays a role in responding to osmotic stress. The protein target of the chemical differs widely between citrus greening disease and gout, but the protein-chemical interaction is similar enough to allow protein inhibition. Is there a link between the microbiome and diabetes? 10 years ago, Lactobacillus johnsoniican rescue animals that are predisposed to diabetes. L. johnsoniiinactivates a host enzyme, IDO, which regulates proinflammatory responses. Activated immune cells can travel to the pancreas and attack beta cells, leading to diabetes. Regulating the proinflammatory response by administering L. johnsoniias probiotics offers the opportunity to control development of diabetes in predisposed people.   Links for This Episode MTM Listener Survey, only takes 3 minutes. Thanks! Graciela Lorca’s lab website Pagliai F.A. et al. The Transcriptional Activator LdtR from ‘Candidatus Liberibacter asiaticus’ Mediates Osmotic Stress Tolerance. PLoS Pathogens. April 2014. Lai K.K., Lorca G.L. and Gonzalez C.F. Biochemical Properties of Two Cinnamoyl Esterases Purified from a Lactobacillus johnsonii Strain Isolated from Stool Samples of Diabetes-Resistant Rats. Applied and Environmental Microbiology. August 2009. Marcial G.E. et al. Lactobacillus johnsonii N6.2 Modulates the Host Immune Response: A Double-Blind, Randomized Trial in Healthy Adults. Frontiers in Immunology. June 2017. HOM Tidbit: Hartmann A., Rothballer M., and Schmid M. Lorenz Hiltner, a Pioneer in Rhisophere Microbial Ecology and Soil Bacteriology Research. Plant and Soil November 2008.    

Federation Account Allocation Committee (FAAC) disbursed the sum of N679.7bn to the three tiers of government in June 2019 from the revenue generated in May 2019. The amount disbursed comprised of N571.73bn from the Statutory Account, N106.83bn from Valued Added Tax (VAT) and N1.41bn exchange gain differences. Federal Government received a total of N284.16bn from the N679.70bn. States received a total of N187.61bn and Local Governments received N140.10bn. The sum of N40.44bn was shared among the oil producing states as 13% derivation fund. Revenue generating agencies such as Nigeria Customs Service (NCS), Federal Inland Revenue Service (FIRS) and Department of Petroleum Resources (DPR) received N5.55bn, N11.03bn and N5.92bn respectively as cost of revenue collections. Further breakdown of revenue allocation distribution to the Federal Government of Nigeria (FGN) revealed that the sum of N227.44bn was disbursed to the FGN consolidated revenue account; N5.10bn shared as share of derivation and ecology; N2.55bn as stabilization fund; N8.57bn for the development of natural resources; and N6.09bn to the Federal Capital Territory (FCT) Abuja.--- Support this podcast: https://anchor.fm/newscast-africa/support --- Support this podcast: https://anchor.fm/newscast-africa/support Learn more about your ad choices. Visit megaphone.fm/adchoices

 Ahead of the deadline given by the National Insurance Commission (NAICOM) for insurance firms to recapitalize, Consolidated Hallmark Plc has revealed its plan to raise its capital base from N6.1 billion to N10 billion. It is seeking an additional N3.9 billion to meet the new capital requirement, after it's capital base has been increased from N3 billion to N10 billion. While maintaining that its first line of action would be to issue additional share by way of a rights issue, Consolidated Hallmark made known that it is important it shares its plans with shareholders and stakeholders to get their support to realize the new target. According to the insurance firm, the rights issue would give existing shareholders the opportunity to increase their stakes in the company and take the benefit of a lower offer price than that of a public offer. Consolidated Hallmark, however, hinted that other options available to the company to achieve the additional capital required were private placement, public offer or merger, and acquisition. Recall that NAICOM of recent announced an increment in the minimum paid-up share capital of insurance and reinsurance firms. --- Support this podcast: https://anchor.fm/newscast-africa/support --- Support this podcast: https://anchor.fm/newscast-africa/support Learn more about your ad choices. Visit megaphone.fm/adchoices

Remember those wacky songs from the 70s and 80s that made us laugh and/or annoyed the crap out of us? How about the haunting ones that gave us totally creepy feelings? We sure do, and are sharing some of our favorites on this week's episode. Also included: Do your pets sleep in your bed? Do you recall the wild hairstyles from back in the day? We discuss these topics, badassery, and more. Listen in! Enjoy these choice videos of our favorite novelty songs:   https://youtu.be/Fsj2wdFDmLk "Escape (The Pina Colada Song)" by Rupert Holmes https://youtu.be/XtzoUu7w-YM "The Streak" by Ray Stevens https://youtu.be/9vST6hVRj2A "The Wreck of The Edmund Fitzgerald" by Gordon Lightfoot https://youtu.be/nv33eaygVDQ "Ode to Billy Joe" by Bobby Gentry https://youtu.be/Qb21lsCQ3EM "Valley Girl" Frank and Moon Unit Zappa https://youtu.be/zcSlcNfThUA "Tiptoe Through the Tulips" by Tiny Tim https://youtu.be/lOfZLb33uCg Honorable 90s mention: "Amish Paradise" by "Weird" Al District https://youtu.be/N6_k_EIa87o Honorable '90s Mention: "Boogie in Your Butt" by Eddie Murphy

Cries for better services by thousands of jobless young people within the Amahlathi Municipality in the Eastern Cape have finally been heard. The municipality has been placed under provincial administration following months of violent protests which led to the torching of municipal buildings and a clinic. Officials within the municipality are accused of providing jobs in exchange of sexual favours, nepotism, fraud and corruption. The municipality, based in Stutterheim is situated along the N6 connecting East London and Johannesburg.

Norrland utgör faktiskt över halva Sverige men norrlänningar klumpas ändå ofta ihop som om alla vore lika. Hur ser din del av Norrland ut? Aldrig är väl skillnaden i livsvillkor så tydliga i vårt avlånga land som nu i januari. I söder är det snöblask, i norr rejält snödjup och bitande köld. I Naimakka var det minus 39,3 grader i veckan, ett köldrekord för i år. Men är norra Norrland och södra Sverige som två olika världar? Vad är det mer än vädret som skiljer tycker du som bor i övre halvan? Vad fick dig att flytta till Norrland? Vad fick dig att flytta därifrån? Norrland utgör 59,6 procent av Sveriges yta och det är faktiskt 80 mil mellan Gävle och Kalix. Men bara omkring 12 procent av Sveriges befolkning bor i de nio norrländska landskapen, från Gästrikland i söder till Lappland i norr. Hur är livet i där du bor? Vad gör det med samhällsservice och livsvillkor när det är så glest befolkat? Vad är charmen med att bo i Offerdal, Abborträsk, Vittangi eller Sveg? Och vad är utmaningen? Norrlänningar framställs ofta som omoderna och bakåtsträvande människor som bor i en avfolkningsbygd. I sex kommuner (Sundsvall, Östersund, Örnsköldsvik, Umeå, Skellefteå och Luleå) pågår därför det så kallade N6-initiativet där kommunledningarna tillsammans försöker förändra bilden i media och hos beslutsfattare. De vill hellre framhålla det moderna, urbana och kreativa norra Sverige. Vill du också nyansera bilden av en norrlänning och platsen där du bor? Och du som flyttat söderut - vilken är din bild nu av norr? Ring 099-110 90 till Pernilla Arvidsson ikväll och berätta om ditt Norrland. Eller mejla redan nu till karlavagnen@sverigesradio.se

The Neapolitan chord and the Neapolitan Sixth chord add a very distinctive sound to a progression. You've heard it many times and you probably LOVED it. Now you're going to learn all about it! We will discuss how to build one, how it's used in a progression and we'll play a few examples you may recognize. This ain't just some boring ice cream favor. This is good music!

Welcome to another episode of Biotechnology Focus radio. I am your host – Michelle Currie – here to give you the rundown on the Canadian biotech scene! Coming up we have some inspiring research from the University of Alberta regarding viral pathogen treatment; McMaster researchers have a new hypothesis on Huntington’s Disease; RepliCel solidifies co-development deal in Greater China; scientists discover a way to genetically screen for acute myeloid leukemia; and putting Canada in the limelight when it comes down to artificial intelligence and deep learning.   Keep on listening to find out more of the details!  +++++  The University of Alberta appears to have hit the nail on the head yet again. With so much inspiring research coming out of this campus, it should come as no surprise that they have made a significant discovery that has the potential to treat viral pathogens such as the Zika virus and respiratory syncytial virus (RSV).  Scientists from UofA discovered a new and promising class of chemical compounds that is comparable to the naturally occurring isatisine A, an antiviral originally found in traditional Chinese herbal medicine.  Fred West, a professor in the Department of Chemistry, who led the discovery along with RSV researcher David Marchant, a professor in the Department of Medical Microbiology and Immunology, says, “This is both a remarkable scientific discovery and also something that has the potential to positively affect not only global health but also the economy of Canada.”   West and Marchant worked in conjunction with Zika expert and cell biologist Tob Hobman, who is also a professor in the Faculty of Medicine & Dentistry at the University of Alberta. They tested the compound against potent viruses, such as Zika and respiratory syncytial virus , that yielded remarkable results. The compound was active and effective against both viral infections.  The Zika virus, which is a mosquito-borne pathogen, began wreaking havoc in May of 2015 after it had been identified as the culprit behind an outbreak of prenatal defects across South America. It coincided with a 2,700 per cent increase in Brazil from reported cases of microcephaly, an often fatal congenital condition associated with incomplete brain development in newborns.  Whereas, relatively unheard of respiratory syncytial virus poses a greater threat to infants, the elderly and those with compromised immune systems. This virus is responsible for up to 30 per cent of hospitalized respiratory cases in any given year.   West adds, “What we aim to do is further refine this compound to keep the elements that make it medically active and build in the structural components that make it possible for patients to consume in drug form. We are approaching that point.”  The next stage of drug development is already underway, and with Marchant’s new company Antibiddes Technologies Inc. ready to license the intellectual property and begin commercialisation, this is a promising development that could change the face of viral pathogen treatment.  ++++++  McMaster researchers develop a new theory regarding Huntington’s Disease that may shape the future of drug development for the disease.  A team of researchers from the university found that a unique type of signalling found in damaged DNA signals huntingtin – a harmful mutant protein found in the genes of those diagnosed with Huntington’s Disease – to aid in DNA repair is defective for those with the condition.  The new hypothesis was published in the Proceedings of the National Academy of Science (PNAS).  Laura Bowie, a PhD student in the Department of Biochemistry and Biomedical Sciences at McMaster, says, “The concept was that if we applied the signalling molecule back in excess, even orally, this signalling can be restored in the Huntington’s disease mouse brain. The net result was that we fixed the modification of huntingtin not seen in mutant huntingtin in Huntington’s disease.”  Using this hypothesis, the study team discovered a molecule called N6-furfuryladenine, derived from the repair of DNA damage, which corrected the defect seen in mutant huntingtin.  “Based on dosing by different ways of this molecule in mouse Huntington’s disease models, Huntington’s disease symptoms were reversed,” says Bowie. “The mutant huntingtin protein levels were also restored to normal, which was a surprise to us.”  Ray Truant, senior author on the study, has dedicated his career to Huntington’s disease research and how mutation leads to Huntington’s disease. It was his lab that was the first to demonstrate that normal huntingtin was involved in DNA repair.  Truant argues that the traditional and controversial amyloid/protein misfolding hypothesis, where a group of proteins stick together forming brain deposits, is likely the result of the disease, rather than its cause.  He also stated that he considers this paper the most significant of his career, and that “This is an important new lead and a new hypothesis, but it is important for people to know this is not a drug or cure. This is the first new hypothesis for Huntington’s disease in 25 years that does not rely on the version of the amyloid hypothesis which has consistently failed in drug development for other diseases.”  Huntington’s Disease is an inherited, neurodegenerative illness that comes with dire physical, cognitive and emotional symptoms that often hit around middle age. The mutant huntingtin protein causes certain parts of the brain to die – specifically the caudate, the putamen and, as the disease progresses, the cerebral cortex.  Bev Heim-Myers, CEO of the Huntington Society of Canada adds “Innovative research initiatives, such as the work led by the team in Dr. Truant’s lab, including PhD student Laurie Bowie, has the potential to transform HD research. The answers we find for Huntington’s disease will likely lead to better understanding of treatments for other neurological diseases and it is important that we continue this cross-talk amongst neurodegenerative diseases.”  The study was conducted in partnership with the University of Alberta, Western University, Johns Hopkins University, and a collaboration with a U.S. biotech firm, Mitokinin LLC. Their work now continues in developing better derivatives of N6-furfuryladenine towards developing a drug.  This study was funded by the Canadian Institutes of Health Research, the Krembil Foundation, and the Huntington Society of Canada.  +++++  Vancouver-based Replicel Life Sciences announces that they have signed definitive agreements with YOFOTO, a Chinese company, solidifying their partnership to commercialise three of Replicel’s programs in Greater China.    The collaboration focuses on the development and commercialization in Greater China of RepliCel’s tendon regeneration cell therapy (RCT-01), skin rejuvenation cell therapy (RCS-01), and its injection technology in development for dermal applications (RCI-02) (excluding hair-related treatments).  YOFOTO Chairman states, “YOFOTO is a fast-growing company built on values related to beauty and healthy, active lifestyles. As a key part of developing and commercializing products related to these core values for our consumers, we are committed to being a leader in China in the commercialization of regenerative medicines.  The RepliCel cell therapy and injection technologies focused on skin rejuvenation and tendon repair are important building blocks in YOFOTO’s strategic healthcare vision. We are pleased to have structured a deal with RepliCel which results in YOFOTO not only being a development partner and commercial licensee but also an investor committed to contributing to RepliCel’s global success.”  YOFOTO’s investment in Replicel will include milestone payments, minimum program funding commitments, and sales royalties in exchange for an exclusive 15-year license to three of RepliCel products for Greater China (Mainland China, Hong Kong, Macau, and Taiwan). Additionally, YOFOTO commits to spending a minimum of C$7 million on Replicel’s programs and associated cell processing manufacturing facility over the next five years in Greater China.  RepliCel president & CEO, Lee Buckler says, “In 2017 RepliCel delivered successful phase I data in all three of its cell therapy programs and functioning prototypes of its next-generation dermal injector,” says “We were committed to delivering a landmark partnership to RepliCel shareholders in 2018. The partnership with YOFOTO represents such a deal and provides RepliCel with not only an outstanding partner in Greater China but capital to move our programs forward in Europe and North America,” he adds.  The deposit of over $5 million has been paid by YOFOTO, but remains in escrow following the closing of the transaction. Once YOFOTO has met certain conditions and once relevant Chinese patents are issued in China, they will be assigned a YOFOTO-owned Canadian subsidiary.  This is very exciting news for Replicel and Canada alike, as Canadian biotech companies begin to spread across the Pacific, with more foreign companies seeking to invest in Canadian innovation and research.  +++++  An international team of scientists discovers a technique that predicts healthy individuals who are at risk of developing acute myeloid leukemia (AML), which is an aggressive and often deadly form of blood cancer.  The findings, published in Nature, illuminate the ‘black box of leukemia’ and answer the question of where, when and how the disease begins, says co-principal investigator Dr. John Dick, Senior Scientist at Princess Margaret Cancer Centre, University Health Network.  Dr. Dick, who is a professor, Department of Molecular Genetics, University of Toronto, holds the Canada Research Chair in Stem Cell Biology, and is co-leader of the Acute Leukemia Translational Research Initiative at the Ontario Institute for Cancer Research, says, “We have been able to identify people in the general population who have traces of mutations in their blood that represent the first steps in how normal blood cells begin on a pathway of becoming increasingly abnormal and puts them at risk of progressing to acute myeloid leukemia. We can find these traces up to 10 years before acute myeloid leukemia actually develops. This long-time window gives us the first opportunity to think about how to prevent acute myeloid leukemia.”  Study author Dr. Sagi Abelson, a post-doctoral fellow in the Dick lab, says: “acute myeloid leukemia is a devastating disease diagnosed too late, with a 90 per cent mortality rate after the age of 65. Our findings show it is possible to identify individuals in the general population who are at high risk of developing acute myeloid leukemia through a genetic test on a blood sample. The ultimate goal is to identify these individuals and study how we can target the mutated blood cells long before the disease actually begins.”  The study stems from Dr. Dick’s 2014 discovery that a pre-leukemic stem cell could be found hiding amongst all the leukemia cells that are present in the blood sample taken when a person is first diagnosed with acute myeloid leukemia. The pre-leukemic stem cell still functions normally but it has taken the first step in generating pathway of cells that became more and more abnormal resulting in acute myeloid leukemia (Nature, February 12, 2014).  Dr. Dick says, “Our 2014 study predicted that people with early mutations in their blood stem cells, long before the disease appears and makes them sick, should be able to be detected within the general population by testing a blood sample for the presence of the mutation.”  The team extracted the data from more than 100 participants who developed acute myeloid leukemia six to 10 years after joining the study, plus the data from an age-matched cohort of more than 400 who did not develop the disease.  Dick adds, “We wanted to know if there was any difference between these two groups in the genetics of their ‘normal’ blood samples taken at enrollment. To find out, we developed a gene sequencing tool that captured the most common genes that get altered in acute myeloid leukemia and sequenced all the 500 blood samples.”  The gene sequencing tool was a success and picked up mutations years before an individual was diagnosed with acute myeloid leukemia to accurately predict those at risk. Moreover, the team used advanced computational technology to assay the information obtained from routinely collected blood tests taken over 15 years in Israel and housed in a massive database of 3.4 million electronic health records.  The study has linked acute myeloid leukemia with a common feature of aging called ARCH-age related clonal hematopoiesis, whereby blood stem cells acquire mutations and become a little more proliferative. The majority of people that have ARCH will not develop acute myeloid leukemia. It is a requirement to have acute myeloid leukemia, but not the other way around.  +++++  Machine learning is augmenting human ability and drastically changing possibilities. It is restructuring businesses and rewiring brains for transformative thinking. Whether it be to develop vaccines for deadly diseases or combat climate change, Canada is at the forefront of this monumental shift.  Canada has been on the vanguard of machine learning long before it became a popular headline. The growth and brilliant minds from around the country have led the way for Canada to place its mark with AI on the world and build a more promising ecosystem for the future.  Across the country, there have been several companies lending a hand in this newer and multi-faceted industry that will reshape history. Among those, innovative researchers are developing imaging devices for skin cancer, diagnostic platforms that analyse natural speech to detect dementia and mental decline, advanced signal analysis to diagnose coronary artery disease, just to name a few, and numerous others that stem to topics unrelated to health care, but keep Canada at the forefront of change.  This year Canada had its 31st Canadian Conference in Artificial Intelligence that stands to show how long Canada has been involved with this game-changing technology. Events like this bring together hundreds of leaders in research, industry, and government that provide a melting pot of inquisitive and like-minded people.  Life sciences is an industry that is filled with innovation and offers much economic promise for governments who desire to grow a knowledge-based economy. Therefore, Biotechnology Focus, in support of Global Biotech Week, is conducting a survey to gauge Canada’s innovation culture. The results will be featured in a special report in the September issue.  The report will highlight trends, identify areas of strengths that can be leveraged as well as opportunities for improvement to support growth for the Canadian life sciences industry.  Artificial intelligence and deep learning have the potential to revolutionize healthcare, and with Canada as a global frontrunner, we can expect to see exponential shifts in the upcoming years to come.  Add your voice to the survey at https://www.surveymonkey.com/r/BioFocus2018.   ++++++  Well, that wraps up another episode of Biotechnology Focus radio! Thanks for tuning in! And let’s remember that with Canada in the limelight it is important for everybody in the life sciences industry to make their voice heard, so please fill out the quick innovation survey so we can continue to enhance this spectacular industry and elevate health care. Until next time, from my desk to yours – this is Michelle Currie.  

Chegamos ao terceiro episódio do Podcast Microbiando e nele discutimos um artigo que demonstra como bactérias que vivem na nossa pele podem produzir uma molécula que protege contra o câncer de pele. Esse artigo foi publicado na revista científica Science Advances em fevereiro de 2018 com o título “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia”. No quadro Microlitros de Notícias: uma breve pipetada de novidades da Microbiologia e Imunologia, abordamos os seguintes assuntos: a atividade do leite materno no combate à células tumorais; a utilização de bactérias vampiras contra infecções bacterianas; a descoberta de uma enzima bacteriana capaz de degradar plásticos; e algumas dicas sobre a febre amarela. Na Filogenia da Ciência, iremos trazer a história de um pesquisador muito importante para nós do Instituto de Microbiologia, o professor Paulo de Góes.   Tópicos comentados nesse episódio Microbiota Staphyloccocus epidermidis Atividade antimicrobiana Molécula 6-HAP Fármacos antitumorais Quimioterápico Tumores Prevenção do câncer de pele Leite materno no combate à células tumorais Bactérias vampiras contra infecções bacterianas Enzima bacteriana capaz de degradar plásticos Dicas sobre a febre amarela A vida de Paulo de Góes e do Instituto de Microbiologia/UFRJ   Referências desse episódio Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018 Feb 28;4(2) Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017 Feb 22;9(378). Plitzko B1, Havemeyer A1, Kunze T1, Clement B2. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol. 2002 Jul;3(7):415-24. Review. James C. S. Ho, Aftab Nadeem e Catharina Svanborg. HAMLET – A protein-lipid complex with broad tumoricidal activity. Biochemical and Biophysical Research Communications. 482: 3, 15 January 2017. Ines Ambite. HAMLET, a new concept for cancer therapy. 2017. Shatzkes, K. et al. Predatory bacteria: a new therapeutic approach for a post-antibiotic era. Future Microbiology. Maio de 2017. Shatzkes, K. et al. Examining the efficacy of intravenous administration of predatory bacteria in rats. Scientific Reports. Maio de 2017. Shatzkes, K. et al. Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model. Nature. Março de 2015. Yoshida et al. A bacterium that degrades and assimilates poly(ethylene terephthalate). Science. Março de 2016 Austin, H. P. et al. Characterization and engineering of a plastic-degrading aromatic polyesterase. PNAS.  Abril de 2018   Sobre o Podcast Microbiando A ideia do Microbiando é discutir artigos científicos de ponta em todas as áreas da microbiologia e imunologia. Vamos utilizar uma linguagem bem acessível para destrinchar esses artigos para vocês, mas sem perder o rigor científico e analítico necessário para essa tarefa. Além de discutir artigos nós teremos o quadro Microlitros de Notícias, onde nossos microbiologistas e imunologistas de plantão irão abordar pequenas reportagens e trazer novidades para vocês. No quadro filogenia da Ciência vamos contar um pouco sobre a vida de grandes personalidades que revolucionar...

Last month, live on Facebook, self-styled biohacker, Tristan Roberts injected himself with a gene called N6. He hopes it will help his body produce an antibody that fights the virus that causes AIDS. But not everyone is on board. Why? Because it's untested and unregulated. Roberts is part of a growing community of bio-hackers. They believe they can get medical cures to the market, faster and cheaper than others held back by regulations. But many in the medical community are outraged. They call Robert's behaviour delusional, risky and frightening.

Tracklist: 01. Edward Artemiev — Station (MIR 100708) 02. Gedankenexperiment — Conclusion (WeMe 313.5) 03. Zwischenwelt — Clairvoyant (Rephlex CAT 214 CD) 04. The Exaltics — Compressed Thoughts (Electronic Explorations 248) 05. Privacy — No Way Back (Klasse Wrecks 004) 06. Umwelt — Structur Noir (forth. Mosaique MSQ001) 07. 2000 And One — Shift 3 (Intacto INTAC054) 08. Juras Lietus — UFOL (Studio R003) 09. Leiras — Emisario (Ownlife OWN001) 10. Qindek — Modu (Wolfskuil WOLF031) 11. Max M — Exceeding Brightness (M_RECLTD24) 12. Harry Light — Tube (Studio R003) 13. Hupnosaurus — Muru (Bookworms Remix) (Wicked Bass WB017) 14. Benjamin Brunn — Gamma Delta Epsilon (ARMA10) 15. Журнал «Кругозор» 1973 N6. Электронная музыка (Журнал с гибкими грампластинками)

What does it mean to love wholeheartedly? This week, Jen shares her real love story and shows us the importance of being yourself in a relationship and not sweating the small stuff! She also shares some great advice for singles who are looking for a healthy and happy relationship. As well as some pretty wise words…“Never hold back in love” We couldn’t agree more… Recorded at The Greenhouse studio, N6