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Evolving with Nita Jain: Health | Science | Self-Improvement
In this episode of Evolving, Nita Jain talks with Richard Sprague, a software engineer, quantified self enthusiast, and co-founder of personal health tracking startups. Sprague discusses the complexities of the microbiome, the limitations of single-point microbiome testing, and the importance of longitudinal sampling.He shares insights from his extensive self-experimentation data collection, discussing fasting, probiotics, and the impact of alcohol on glucose levels. Sprague also touches on how personal science can empower individuals to optimize their health by tailoring approaches to fit their unique biological responses.The Journey into Personal ScienceRichard Sprague's journey into personal science began with his background in software engineering and an early fascination with computers. Observing the parallels between computer systems and human biology, he developed an interest in tracking genes and other biological markers. This led him to explore how personal experimentation can inform individual health insights—a theme central to the quantified self movement.Are We Human or Are We Computers?Sprague dives into the complexities of the human microbiome—an intricate system comprising trillions of microorganisms living in and on our bodies—and emphasizes that comparing the microbiome to a computer algorithm oversimplifies its complexity. The human microbiome is a dynamic system influenced by a myriad of factors, including genetics, environment, and lifestyle.Jain and Sprague discuss the challenges of microbiome testing and the importance of longitudinal sampling to capture a more accurate picture of the gut microbiome. Richard emphasizes that single-point microbiome tests can be misleading due to the natural diurnal variation and the inherent compositional problem in sampling.Promise & Pitfalls of Microbiome TestingOne of the key pitfalls in interpreting microbiome results is the variability introduced at multiple stages of microbiome testing, from sample collection to data processing. Sprague highlights the significance of working with the same lab using consistent protocols to ensure reliable results. He also emphasizes the importance of understanding that many factors can skew microbiome readings, leading to potentially misleading conclusions.The Power of Self-ExperimentationSprague introduces the concept of personal science, or n-of-one studies, where individuals engage in self-experimentation to find what works best for their unique biology. He shares insights from his own experiments with kombucha, probiotics, and dietary interventions like fasting, highlighting how these experiences have informed his understanding of his microbiome and overall health.Embracing Curiosity and MindfulnessSprague stresses the importance of maintaining curiosity and skepticism about health practices and recommendations and encourages listeners to be mindful of their own body and health, considering personal experimentation as a powerful tool for gaining insights and making informed decisions.Subscribe to the podcast at nitajain.com!Time Stamps00:00 Richard Sprague's Background00:45 Journey into Tech and Personal Science02:32 Complexity of Human Biochemistry vs. Computers05:24 Microbiome Testing and Its Challenges06:52 Pitfalls in Interpreting Microbiome Results16:57 Personal Science and Self-Experimentation25:06 The Impact of Microbiome on Health25:47 Personal Microbiome Discoveries27:19 Critical Windows for Microbiome Development28:00 Manipulating the Microbiome31:58 Microbiome and Disease Hypotheses36:25 Fasting and Microbiome Health39:11 Personal Science and Self-Experimentation45:17 Surprising Personal Experiment Results47:19 Conclusion and Final Thoughts Get full access to Evolving with Nita Jain at www.nitajain.com/subscribe
Book: JFK Medical Betrayal: Where The Evidence Lies by Russell Kent: Kindle Jim DiEugenio reviews Russell Kent's book JFK Medical Betrayal How Russell got interested in the JFK case www.dealeyplazauk.com Article: How Five Investigations into JFK's Medical/Autopsy Evidence Got it Wrong by Dr. Aguilar Russell Fisher of the Clark panel Dr. Pierre Finck was very inexperienced Finck became a board-certified forensic pathologist in 1961; just 2 years before the assassination Finck arrived late at the autopsy The two autopsies at Parkland and Bethesda The two sets of conflicting observations at Parkland and Bethesda Fisher changed the location of the head wound The Rockefeller panel had five doctors; two of whom were military The remaining three doctors were all associated with Fisher The HSCA medical panel The interconnections of various doctors on the medical panels: check here The disservice of Dr. Michael Baden Many of the top people of the ARRB were Warren Commission supporters Video: Tucker Carlson on JFK Assassination, Dec 15, 2022 Richard Sprague and Robert Tanenbaum of the HSCA Video: The collapse of WTC Building 7 Rage Against the War Machine Anti-war rally, Washington, D.C., Feb 19 2023 Video: Ukraine More Important Than German Suffering Says GERMAN Foreign Minister (The Jimmy Dore Show) Kent working on a new book about the Nazi war crime trials Get in touch with Russell Kent at r_kent@hotmail.com
Papers of Jim Garrison (2 gigs) Download one week only At Kennedys and King Article: Barry Ernest Replies to John Armstrong, RE: Victoria Adams Article: James Moore, JFK, and QAnon by Jim DiEugenio The JFK case does not rely on faith It relies on testimony, exhibits, logic and proof Free virtual conference titled “The National Security State and the Kennedy Assassination” by Jacob Hornberger Conference to begin on March 3rd Speakers include Jim DiEugenio, Mike Swanson, Jefferson Morley, Douglas Horne, Jacob Hornberger More details about the conference here Click here to register for the conference Watch Jim DiEugenio's presentation at the conference titled President Kennedy and the Third World Article: Randy Robertson reviews Josiah Thompson's new book Last Second in Dallas Article: Martin Hay reviews Josiah Thompson's new book Last Second in Dallas Article: MLK & Fred Hampton Versus J. Edgar Hoover by Jim DiEugenio Fred Hampton, the FBI and COINTELPRO Hampton's apartment was raided by the FBI at 4:30 am 99 bullets in the raid by the FBI Please make sure to check the news section at kennedysandking News: Deathbed Letter From Former Cop Claims NYPD, FBI Helped Kill Malcolm X News: Daughter of Former NYPD Officer Says Malcolm X Assassination Letter is Fake News: John F. Kennedy: When the US president met Africa's Independence Heroes Article: New Documents Confirm Role of Convicted Malcolm X Assassins Butler and Johnson by Karl Evanzz Article: The Purloined Letter: Daughter of Agent Provocateur Labels Book A Hoax by Karl Evanzz John Mcadams - Laughing stock of the Internet? Article: Anatomy of an Online Atrocity: Wikipedia, Gamaliel, and the Fletcher Prouty entry Article: The Real Wikipedia? Will the Real Wikipedia Please Stand Up? by J.P. Mroz Article: The Real Wikipedia? Part Two: Please, Mr. Wales, Remain Seated by J.P. Mroz Wikipedia is the same thing as The New York Times when it comes to the JFK assassination; maybe worse A five-article series reviewing the research of Fred Litwin by Jim DiEugenio Article: Litwin and the Warren Report by Jim DiEugenio Article: Fred Litwin, On the Trail of Delusion – Part One by Jim DiEugenio Article: Fred Litwin, On the Trail of Delusion – Part Two by Jim DiEugenio Article: Fred Litwin, On the Trail of Delusion – Part Three by Jim DiEugenio Article: Fred Litwin: Culture Warrior by Jim DiEugenio The first incarnation of the HSCA with Richard Sprague (lawyer), Bob Tanembaum and Al Lewis An all-day conference held by the lawyer Sprague featuring Robert Cutler, Robert Groden and Richard E. Sprague Of the 13 lawyers attending at the conference, 12 believed that the JFK case was a conspiracy Richard E. Sprague had the largest photographic collection on the JFK case "I'd much rather defend Oswald than prosecute him" - Jeremy Gunn, ARRB Jim Garrison's early days in the JFK case FREE Borrowable Ebook: On the Trail of the Assassins by Jim Garrison Oswald probably worked for both the CIA and the FBI Too many researchers think that they know about the New Orleans aspect of the case but don't Book: Destiny Betrayed: JFK, Cuba and the Garrison Case by Jim DiEugenio: Paperback, Kindle The book American Grotesque by James Kirkwood was written at the request of Clay Shaw Litwin relies on Kirkwood's book and the archives of Shaw's lawyers Litwin begins his book with the character assassination of Jim Garrison Litwin's other sources include Hugh Aynesworth, Harry Connick, Rosemary James, Patricia Lambert, et al Book: Let Justice Be Done by Bill Davy: Paperback, Kindle There is no evidence to connect Ferrie with Oswald according to Litwin !!! In the 5 days post assassination, Ferrie tried three times to confiscate evidence linking him to Oswald Ferrie's consciousness of guilt Litwin tries to say that Garrison was looking for Clay Bertrand in 19...
Richard Sprague is a veteran technologist from Apple and Microsoft who has done over 600 microbiome tests using skin, nose, and fecal samples over the last six years. His fascination with his gut microbiome has led him to start Personal Science, a personalized nutrition project to help people discover their ideal diet by helping them track their glucose responses to doctor-prescribed meals. We speak with him about the future of gut microbiome testing and personalized diets that are projected to become a $64bn market in the next two decades.
Richard Sprague from Sprague's Sports in Yuma talks with the GunGuy at SHOT Show 2020 about guns and gun rights in the great state of Arizona.
What is the best diet? This question remains the million (probably billion) dollar question in health, nutrition and medicine. The winner will likely be the healthy diet is one that prevents the most disease and weight gain. Now there seems to be an approach that has caught the attention of patients and providers internationally and that looking at individualized post-meal glucose response as a guide to one’s individualized diet. And guess what? The researchers say that the post meal glucose response is largely dependent as to what kinds of bugs are growing in our gut. Listen in on today’s episode as we explore the individualized diet and post meal glucose response. Some back ground information. Post meal glucose response is defined classically as the rises in blood glucose measured in ng/dl. Why does it matter? As a biomarker it predicts one’s ability to regulate glucose. Glucose regulated means less inflammation in the body, less risk for heart disease, less risk for diabetes, less risk for kidney disease, less risk for eye disease, and less risk for obesity…you get the picture. Typically in a non-diabetic a fasting blood glucose will range from 70 ng/dl to 99 ng/dl and after eating a carbohydrate containing meal the blood glucose will rise between 100 ng/dl-140ng/dl. This can be influenced by protein and fat content in the food source however it is largely driven by carbohydrate intake. Until researchers started looking to the gut microbiome, the large dietary agencies that be would look at glucose content of foods and make predictions as to how these foods would spike blood sugar. This list is called the glycemic index of foods. Then later they looked at how combinations of foods might spike one’s glucose and this is called glycemic load. Now a group out of the Weizmann Institute developed a test and algorithm of post meal glucose response based on DNA sequencing of the bugs that are growing in human guts. By monitoring glucose response in human subjects, they were able to predict that one’s own signature gut microbiome, can largely influence ones glucose response to food. about our guest Richard Sprague is a heath technology executive, biohacker, citizen scientist and engineer. He is quite the interesting man. He is the CEO of Airdoc (a medical technology company). He has been quite involved with Stool Microbiome testing using 16s rRnA metabolome sequencing. At one point he worked with Ubiome one of the pioneers in stool microbiome testing. He must own the record for the number of times he has tested his own stool microbiome (over 300). With this background he brings an interesting perspective on what is actionable within gut microbiome data. --- Support this podcast: https://anchor.fm/adam-rinde/support
Richard Sprague is an experienced technology executive and biohacking enthusiast. He’s served as a high-level executive at both Apple and Microsoft, and worked for numerous startups, including WebTV Networks. He also co-founded Ensembio, a personal health tracking startup. He has a degree in computational linguistics from Stanford and an MBA from Wharton. Recently, he’s been focused on the gut microbiome -- the ecosystem of bacteria that’s present in the intestines of every human being. Richard has been cataloging and analyzing his own gut microbiome for over a year and is working on an initiative to help others track and analyze the bacteria living inside them. In this episode, we answer questions on the gut microbiome. Should you care about your microbiome? How can you test your microbiome? How does your microbiome change over time? Why are there differences in the microbiome between people? How can you improve your microbiome? We hope you enjoy! P.S. You can get your own uBiome testing using the Personal Science referral program. We recommend you use one of the Explorer kits and use “personalscience” during checkout for 15% discount. About Richard richardsprague.com Richard Sprague Twitter Show Links www.personalscience.com www.ubiome.com The Personal Science Guide to the Microbiome Ken Lassesen’s CFS site How bifidobacterium relates to sleep Bob’s Red Mill potato starch American Gut Project Cavities and microbes
Lauder Japanese Program alum Richard Sprague discusses his career within the Apple/Macintosh Business Unit at Microsoft, as well as his experience working and living and China.
If you want to REALLY know about what is coming in the near(ish) future on Microsoft Response Point - you will want to listen to this. In this weeks podcast I speak with Richard Sprague, Senior Director on the Microsoft Response Point team. We went bullet point by bullet point over the Response Point Roadmap. I think a lot of VAR's (resellers) and customers are going to like what they hear. I know a lot of requests that I hear about from the customers and the community are addressed in the features included in the upcoming Roadmap.
This week I talked about the recent Microsoft Response Point Town Hall meeting attended by about 100 VAR's or interested parties.Microsoft is redesigning the Response Point website and it should be online the first week of November at www.Microsoft.com/responsepointThere was a fair amount of ROAD MAP information that was included in the Town Hall Meeting.VAR Demo Unit Program - Send an email to rpoint@microsoft.com. Include Name, Company Name, Address, Business Phone, Cell Phone, Company URL, MSFT Partner ID #, Date Needed, Description (Sales, Trade Show, etc.)Next weeks show will include an interview with Richard Sprague of the Response Point Team. This conference call is scheduled for Tuesday, November 11 at 7pm Eastern time.