Ancient religion that originated in India
SLAS Scientific Manager Hannah Rosen, Ph.D., is joined by Sapient Founder and CEO Mo Jain, M.D., Ph.D., for an insightful discussion on small molecule biomarkers. Did you know that methods of identifying biomarkers date all the way back to ancient Greece? You'll be surprised to hear how along with the many ways these biomarkers are shaping drug discovery and other applications. Jain also shares his background with small molecule biomarkers that led to him creating Sapient along with the company's own technology platform used for biomarker discovery. To learn more about Sapient, visit: https://sapient.bio/About Mo Jain, M.D., Ph.D.:Jain is a physician-scientist with nearly 20 years of expertise in physiology, biomedicine, engineering, computational biology and mass spectrometry-based metabolomics. Prior to founding Sapient, he formed and was director of Jain Laboratory at the University of California San Diego (UCSD), which focused on developing next-generation rapid liquid chromatography-mass spectrometry (rLC-MS) systems to probe the non-genetic landscape of disease across population-scale human studies. Stay connected with SLAS:Online at www.slas.orgFacebookTwitter @SLAS_OrgLinkedInInstagram @slas_orgYouTubeAbout SLAS:SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building. For more information about SLAS, visit www.slas.org.SLAS publishes two peer-reviewed and MEDLINE-indexed scientific journals, SLAS Discovery and SLAS Technology. For more information about SLAS and its journals, visit www.slas.org/publications.Upcoming SLAS Events:SLAS2023 International Conference and ExhibitionFebruary 25 - March 1, 2023San Diego, CA, USASLAS Europe 2023 Conference and Exhibition23-26 May 2023Brussels, Belgium
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.22.509104v1?rss=1 Authors: LeBel, A., Wagner, L., Jain, S., Adhikari-Desai, A., Gupta, B., Morgenthal, A., Tang, J., Xu, L., Huth, A. G. Abstract: Speech comprehension is a complex process that draws on humans abilities to extract lexical information, parse syntax, and form semantic understanding. These sub-processes have traditionally been studied using separate neuroimaging experiments that attempt to isolate specific effects of interest. More recently it has become possible to study all stages of language comprehension in a single neuroimaging experiment using narrative natural language stimuli. The resulting data are richly varied at every level, enabling analyses that can probe everything from spectral representations to high-level representations of semantic meaning. We provide a dataset containing BOLD fMRI responses recorded while 8 subjects each listened to 27 complete, natural, narrative stories (~6 hours). This dataset includes pre-processed and raw MRIs, as well as hand-constructed 3D cortical surfaces for each participant. To address the challenges of analyzing naturalistic data, this dataset is accompanied by a python library containing basic code for creating voxelwise encoding models. Altogether, this dataset provides a large and novel resource for understanding speech and language processing in the human brain. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
In this episode, host Shikha Jain, MD, speaks with Roberta Gebhard, DO, and Pringl Miller, MD, about empowering physicians through education and advocacy, getting the right help to overcome and protect against workplace inequities and more. Welcome to another exciting episode of Oncology Overdrive :14 About Gebhard :24 About Miller 1:12 The interview: 2:01 Dr. Miller, you went from surgeon to expert in palliative care in hospice, to advocate … What has been your path to where you are today? 2:12 Dr. Gebhard, tell us more about your journey to ascend into leadership positions and how you ended up where you are today 3:57 About Physician Just Equity (PJE) 5:42 Why do you think this is so important right now? … Why do you think now is the time to form an organization like this [PJE], and what are you hoping to accomplish? 9:22 Can you talk about some of the people you've helped? Are there any stories of individuals that you feel are especially important or that are ongoing that we should know about? 13:06 About the case of Dr. Vilasini (AKA Vilasni) Ganesh 16:55 How does something like this happen? 20:37 Is there any benefit to partnering with groups like The Innocence Project or organizations that have worked in this space before? 23:04 What can people do to help with Dr. Ganesh's case? 25:53 Who do you recommend come to PJE? … When should someone reach out to PJE? 27:06 If somebody could only listen to the last minute of today's episode, what would you want them to take away? 33:03 How to contact Miller 33:57 How to contact Gebhard 34:16 Thanks for listening 34:58 Roberta Gebhard, DO, is a family practice physician in Western New York, currently on the Board of Directors of Physician Just Equity. She was the 2019-2020 president of the American Medical Women's Association, is currently the AMWA representative to the American Medical Association Women Physician Section Governing Council and was the founder of the AMWA Gender Equity Task Force. Pringl Miller, MD, is a board-certified general surgeon and hospice and palliative medicine specialist. She is the founder and ED of Physician Just Equity (PJE) and a co-founder of the Surgical Palliative Care Society. We'd love to hear from you! Send your comments/questions to Dr. Jain at firstname.lastname@example.org. Follow us on Twitter @HemOncToday and @ShikhaJainMD. Dr. Gebhard can be reached via email at email@example.com or on Twitter @drrgebhard. Dr. Miller can be reached via email at firstname.lastname@example.org or on Twitter @pringlmillermd. Visit the Physician Just Equity website by searching physicianjustequity.org or on Twitter @equitydocs. Disclosures: Gebhard, Jain, and Miller report no relevant financial disclosures. To make a donation to the Dr. Vilasini Ganesh legal fund: bit.ly/vganesh References: https://www.beckershospitalreview.com/legal-regulatory-issues/california-physician-sentenced-to-5-years-in-prison-for-billing-fraud.html https://cdn.ca9.uscourts.gov/datastore/memoranda/2021/05/24/18-10133.pdf https://greenandassociates.blogspot.com/2018/09/sentencing-update-california-doctor.html https://indicanews.com/2021/11/09/doctor-vilasini-ganesh-claims-courts-railroaded-her-in-fraud-case/ https://www.ndtv.com/indians-abroad/indian-origin-doctor-vilasini-ganesh-her-husband-conspires-to-commit-health-care-fraud-in-california-1909639 https://www.nripulse.com/indian-american-doctor-sentenced-to-63-months-in-prison-says-the-criminal-justice-system-failed-her/ https://www2.mbc.ca.gov/BreezePDL/document.aspx?path=%5CDIDOCS%5C20190124%5CDMRAAAGL1%5C&did=AAAGL190124172444350.DID https://youarewithinthenorms.com/2021/09/11/alpha-phi-alpha-fraternity-speaks-out-against-injustice-done-to-gregory-belcher-md-orthopedic-surgeon-by-federal-government-for-wrong-date-on-a-217-00-invoice-now-faces-prison-time-a-naval-office/
Where should the mindset shift start, and how can you set yourself up for success? Our guest Saket Jain will help us learn what it takes to build a life where you don't have to worry about someone else dictating your financial situation. Gain tons of wisdom by joining us in this talk!Key Takeaways to Listen forQuestions to ask yourself that will shift your mindsetWhy you should initiate to start designing your own life pathTop reasons why people don't have control over their lifeHow to set yourself up for success in real estate The best way to get out of a poor financial situationA great piece of advice on achieving victory in your lifeResources Mentioned in This EpisodeTo get a free copy of Saket Jain's book, go to https://impactwealthbuilders.com/book-launch/ Free Apartment Syndication Due Diligence Checklist for Passive Investor About Saket JainSaket Jain is a #1 bestselling author, investor, syndicator, tech enthusiast, and philanthropist. He is the Founder and CEO of Impact Wealth Builders, where he's passionate about achieving financial freedom through real estate. He has over 15+ years of experience in real estate investing. Over the last 5 years, Saket has taken a particular interest in class B/C multifamily apartments in markets with strong fundamentals. Saket, along with his partners, has built a portfolio of over 2000 units totaling $200M in assets across several US markets, generating consistent double-digit annual returns.In addition to investing, Saket currently serves as a Business Operations leader at Airbnb Headquarters. Prior to that, Saket, in his role as a business consultant, built, launched, and led profitable new ventures in the technology and financial sectorsSaket earned his MBA at Columbia Business School and achieved his Bachelor in Engineering at IIT, India. When he is not working, Saket loves to spend time with his wife of 19 years and 2 daughters.Connect with SaketWebsite: Impact Wealth BuildersConnect With UsPlease visit our website: www.bonavestcapital.com and please click here, to leave a rating and review!SponsorsGrow Your Show, LLCThinking About Creating and Growing Your Own Podcast But Not Sure Where To Start?Visit GrowYourShow.com and Schedule a call with Adam A. Adams.
We are chatting with Chanda Daniels all about how to work and network with luxury wedding planners. Chanda shares her thoughts and advice on how you can start authentically connecting and working with planners inside the luxury space. A little bit about Chanda is that she is recognized as one of the nation's leading LGBTQ+ Wedding Experts, she is the owner & creative director of Chanda Daniels Planning + Design and founder of A Monique Affair, one of the leading event planning companies in the San Francisco Bay area. Visit Website: https://chandadaniels.com Instagram: https://www.instagram.com/cd_chandadaniels Facebook: https://www.facebook.com/groups/1894867207198379 LinkedIn: www.linkedin.com/in/chandadaniels Podcast Sponsor - Pixpa Pixpa is an all-in-one platform for creators and small businesses to create beautiful professional websites. Whether you want to showcase your portfolio, start your business website, set up your online store, or publish a blog - Pixpa empowers creators to manage their whole web presence from one location, saving time and money. With a host of built-in tools such as an Online Store, Blog, SEO Manager, Marketing Pop-Ups, Announcement Bar, and much more, Pixpa offers you all the tools you need to start growing your business online. Pixpa's affordable, all-inclusive plans start at just $7/month and come with 24/7 support, unlimited bandwidth, SSLs, and much more. Start building your website with Pixpa's 15-day full-featured, free trial. Tea with Jainé listeners get a special 50% Discount. Use code TEAWITHJAINE when you subscribe. Love the podcast? Please leave a 5 ⭐️ review on Apple Podcasts. Our Investment Guide Template for Wedding Photographers is available in our online shop. Need help submitting your wedding to publications? We offer 1:1 and Done for You Wedding Curations + Submission Services - click here to book your spot today! Get our Wedding Submissions E-Mail Templates to help make your next online or print submission easier! Stay Connected: Follow @teawithjaine & @jainekershner on Instagram We are looking for Sponsors just like you! Visit Our Website to Apply: www.teawithjaine.com
Rishabh is the co-founder and CEO of Fermat Commerce, a distributed commerce platform built to enable creators to embed brand direct shopping experiences on their own sites.
About the author: Dharmpal Mahendra Jain Born (1952) and raised in tribal reserve of Jhabua, India, Dharm is a Toronto based Author. He writes in Hindi and English. He has seven published books- five collections of satirical essays and two collections of Poetry. He is a columnist for three prestigious journals Chankya Varta, Vishwa Gatha, Setu and Vishwa. His works have appeared in prestigious Hindi journals across the world. His poetry in English has been previously published in Poetry Pause, Fresh Voices, Harbinger Asylum, Akshara, Impspired, Piker Press, Scarlet Leaf Review, Dissident Voice, and Setu. As always, we would love to hear from you. Have you tried sending me a message on the Eh Poetry Podcast page yet? Either way, we would like to reward you for checking out these episode notes with a special limited time coupon for 15% off your next purchase of Mary's Brigadeiro's amazing chocolate, simply use the code "ehpoetrypodcast" on the checkout page of your order. If you are a poet in Canada and are interested in hearing your poem on Eh Poetry, please feel free to send me an email: jason.e.coombs[at]gmail[dot]com Eh Poetry Podcast Music by ComaStudio from Pixabay --- Send in a voice message: https://anchor.fm/ehpoetrypodcast/message
In this episode (and Jing's last for The Pulse!) we are excited to feature Erica Jain, the Co-Founder & CEO of Healthie. At Healthie, Erica empowers health and wellness organizations to launch & scale their businesses and build long-term relationships with their clients to deliver personalized, preventative care. Healthie is an API-forward platform that allows companies to build the back-office infrastructure systems necessary to support patient-centric operations. Healthie uniquely enables companies to effectively dispense longitudinal care. Healthie recently raised $16.5M in Series A funding in a round led by Velvet Sea Ventures with participation from Greymatter Capital, Watershed Capital, and Builders VC. We discussed: Designing a solution to support longitudinal care coordination between patients and their care teams, improving upon the legacy healthcare infrastructure systems geared towards one-time episodic care. Healthie's API-first, out-of-the-box offering enables healthcare companies of any size to focus their resources on developing their core product without sinking resources into creating complex backend systems. The importance of operational excellence for healthcare startups and continued interest from venture capital firms and other investors to accelerate innovation across the healthcare industry.
Places of Worship Act, 1991, Minorities Commission Act, 1992, and Waqf Act 1995 (made more draconian by 2013 amendment) is the troika that virtually makes India's Constitution bow before Islamic Law, and is further fortified by Sachar Committee recommendations. Vishnu Shankar Jain joins Sanjay Dixit to discuss.
The guest for this interview of Out of the Clouds is Siddha Jain, Chief Business Officer at Bombae, by Bombay Shaving Company, a premium women's personal care and grooming brand launched during the pandemic. Siddha is a savvy and creative executive who in her own words followed the expected track, first studying hard to first become an engineer, then obtaining an MBA, and later becoming a consultant at Bain & Company. Host Anne invites Siddha to talk about her story (hint: her goal is to prove herself). She explains how her mother imbued her with vision and taught her the value of being persistent. She then reveals her own vision, with the not-so-hidden aim to become an expert in other fields, essentially a ‘jack of all trades.' Siddha also brings her ikigai, the Japanese concept of having a sense of purpose, and shares how her passion for dance and creating events are extracurricular pursuits that connect her to the greater purpose of her life. The pair touch on Bombae's values and the content strategies that the brand uses to connect with its customers, including a collaboration with India's top women stand-up comedians. And, as a woman at the executive level, Siddha offers her thoughts about what helps her feel confident as well as how and why she brings her full self to work. Then Anne asks Siddha to talk about what it's like to build a brand and design products for a bold and cheeky consumer. Bombae's mission around hair removal is raised, which leads them to explore the complex relationship women in India and around the world have with their body and facial hair. A deeply engaging interview with a thoughtful and passionate woman. Happy listening!***Selected links from episode You can find Siddha Jain on Instagram @eat.dance.styleawayand on LinkedIn - https://www.linkedin.com/in/siddha-jain-65a88353/Maslow's hierarchy of needs https://www.simplypsychology.org/maslow.htmlUnmaad Festival - https://www.unmaad.com/Bain & Company India - https://www.bain.com/offices/india/Jack of all trades full quote - https://en.wikipedia.org/wiki/Jack_of_all_trades,_master_of_noneRoland Mouret - https://rolandmouret.com/Margaret Mead quote - Never doubtCoke Studio TV program - https://en.wikipedia.org/wiki/Coke_Studio_(Indian_TV_program)#BreakTheHairarchy - https://brandequity.economictimes.indiatimes.com/news/advertising/bombay-shaving-company-women-asks-women-to-breakthehairarchy-in-new-campaign/90019262?redirect=1Actress Alaya F - https://www.instagram.com/alayaf/?hl=enStarboy by the Weeknd - https://www.youtube.com/watch?v=34Na4j8AVgAA Man Called Ove, the novel https://www.goodreads.com/book/show/18774964-a-man-called-ove *** If you enjoyed this episode, click subscribe for more, and consider writing a review of the show on Apple Podcasts, we really appreciate your support and feedback, thank you so much for listening! For all notes and transcripts, please visit Out Of The Clouds on Simplecast - https://out-of-the-clouds.simplecast.com/ Sign up for Anne's email newsletter for more from Out of the Clouds at https://annevmuhlethaler.com. Follow Anne: Twitter: @annvi IG: @_outoftheclouds
Episode 131: In today's episode we are excited to give you the second installment of our conversation with guest Saket Jain. He goes deep into his experience with syndication, the lessons he learned and the kind of investor you want to be. Saket is a #1 bestselling author, investor, syndicator, tech enthusiast, and philanthropist Saket Jain is the Founder and CEO of Impact Wealth Builders where he's passionate about achieving financial freedom through real estate. He has over 15+ years of experience in real estate investing. Over the last 5 years, Saket has taken a particular interest in class B/C multifamily apartments in markets that have strong fundamentals. Saket, along with his partners, has built a portfolio of over 2000 units totaling $200M in assets across several US markets, generating consistent double digit annual returns. In addition to investing, Saket currently serves as a Business Operations leader at Airbnb Headquarters. Prior to that, Saket, in his role as a business consultant built, launched and led profitable new ventures in the technology and financial sectors. Check out this episode to find out how to come out on top in the face of uncertainty! For today's episode we will cover: [ 36:51 - 52:01 ] Syndication is a full time job, Why do it?First syndication forayBe the most active passive investorLose our emotional attachment to money [ 52:01 - 58:11 ] Rapid fireWhat do you like to do for your continued education to further your own investing?The single moment of time or maybe event that really changed the course of your business?Advice you would give the listeners to help them grow their businessesTweetable Quotes: Connect With Guest:Website: https://impactwealthbuilders.com/LinkedIn: https://www.linkedin.com/in/jainsaket/E-mail: email@example.com SUBSCRIBE & LEAVE A 5-STAR REVIEW as we create a lifetime of wealth and financial freedom through multifamily investing! Invest with us! Check out Blue Oak Investments: https://blueoakinvests.com/ Cody LaughlinLinkedIn: https://www.linkedin.com/in/cody-laughlin-35067660/Facebook: https://www.facebook.com/cody.laughlin.543 Instagram: https://www.instagram.com/codyblueoakcapital/?hl=enJohn BateyLinkedIn: https://www.linkedin.com/in/johnbatey/ Facebook: https://www.facebook.com/john.l.bateyBrian AlfaroLinkedIn: https://www.linkedin.com/in/balfaro89/Facebook: https://www.facebook.com/brian.alfaro89#activevspassiveinvesting#diversification#multifamily
It's one thing to talk about interoperability in healthcare and it's another to talk about where sharing of health data is really happening. That's the discussion I had with Anil Jain, MD, Chief Innovation Officer at Innovaccer, when I asked him where we're at when it comes to healthcare interoperability. In this video interview, Dr. Jain shares where healthcare organizations are really asking him to help with interoperability. He shares some of the practical areas that interoperability is really happening today. Learn more about Innovaccer: https://www.innovaccer.com/ Find more great health IT content: https://www.healthcareittoday.com/
In this episode, host Shikha Jain, MD, speaks with hematologist, medical educator and University of Pennsylvania director of the women's thrombosis and hemostasis program, Ariela Marshall, MD, about fertility advocacy for patients and physicians, navigating the medical system as physician parents and more. Welcome to another exciting episode of Oncology Overdrive :14 About Marshall :18 The interview: 1:44 How did you get involved and interested in doing the work in the fertility space, and what led you to that world? 3:02 Do you think that some of this is due to the fact the way our healthcare system is set up in a way where women's symptoms are often disregarded, or the way we look at our patients is riddled with implicit bias? Why do you think that this is such a huge problem? 7:30 What has been your experience with physicians and physician infertility? … Is it something that we have ideas of how we can really move the needle and change this? 11:26 Have you noticed any sort of culture shift, or do you think we still have a really long way to go in that space? 17:38 Creating and normalizing an office environment where family is a priority 22:48 Cultures and responses to reproductive health in the physician workforce 29:03 How the overturning of Roe v. Wade is going to impact infertility and fertility treatment 32:06 Is there hope for the future when we talk about these things? … Looking at the data, is this something that we can strive for or may change? 21:03 What are your future plans for this type of work and your research? What are you thinking the next steps are going to be? 26:48 If somebody could only listen to 2 minutes of today's episode, what would you want them to take away? 39:56 How to contact Marshall 41:16 Thanks for listening 43:00 Ariela Marshall, MD, is a hematologist, medical educator and the director of the Women's Thrombosis and Hemostasis program at University of Pennsylvania in Philadelphia, Pennsylvania. We'd love to hear from you! Send your comments/questions to Dr. Jain at firstname.lastname@example.org. Follow us on Twitter @HemOncToday and @ShikhaJainMD. Marshall can be reached on Twitter @AMarshallMD. Disclosures: Jain and Marshall report no relevant financial disclosures.
Episode 130: The road to successful investing is a winding one so today we will learn from our guest Saket Jain about his journey from corporate America, being laid off, deciding he has to take control of his life, and what it takes to be an investor. #1 bestselling author, investor, syndicator, tech enthusiast, and philanthropist Saket Jain is the Founder and CEO of Impact Wealth Builders where he's passionate about achieving financial freedom through real estate. He has over 15+ years of experience in real estate investing. Over the last 5 years, Saket has taken a particular interest in class B/C multifamily apartments in markets that have strong fundamentals. Saket, along with his partners, has built a portfolio of over 2000 units totaling $200M in assets across several US markets, generating consistent double digit annual returns. In addition to investing, Saket currently serves as a Business Operations leader at Airbnb Headquarters. Prior to that, Saket, in his role as a business consultant built, launched and led profitable new ventures in the technology and financial sectors. Check out this episode to find out how to come out on top in the face of uncertainty! For today's episode we will cover: [ 00:00 - 18:36 ] Guest Intro: Saket JainSaket's backgroundYour income cannot be a major source of cash flowTransformation is going to happen [ 18:36 - 36:51 ] Who do I need to become to invest?Diversification vs focusing on one verticalNobody invests their 401K to double next yearPassive takes the emotions out Tweetable Quotes: Connect With Guest:Website: https://impactwealthbuilders.com/LinkedIn: https://www.linkedin.com/in/jainsaket/E-mail: email@example.com SUBSCRIBE & LEAVE A 5-STAR REVIEW as we create a lifetime of wealth and financial freedom through multifamily investing! Invest with us! Check out Blue Oak Investments: https://blueoakinvests.com/ Cody LaughlinLinkedIn: https://www.linkedin.com/in/cody-laughlin-35067660/Facebook: https://www.facebook.com/cody.laughlin.543 Instagram: https://www.instagram.com/codyblueoakcapital/?hl=enJohn BateyLinkedIn: https://www.linkedin.com/in/johnbatey/ Facebook: https://www.facebook.com/john.l.bateyBrian AlfaroLinkedIn: https://www.linkedin.com/in/balfaro89/Facebook: https://www.facebook.com/brian.alfaro89#activevspassiveinvesting#diversification#multifamily
Dhiraj Jain and Steph Silver discuss digital marketing, specifically how it has changed, and what a business must do to stay connected and continue to sell products as the rules of online marketing and digital advertising continue to evolve.What you'll learn:How Dhiraj came to know the digital advertising spaceWhy social and digital advertising isn't as effective as it used to beWhat you should be doing to attract new customersHow to keep customers engaged after the first purchaseAbout Dhiraj Jain:Dhiraj is a seasoned Retail & Consumer industry leader with 20+ years of experience in building and scaling businesses at the intersection of strategy, product, and technology. His innate capability to lead and always challenge the status quo in the Retail & Consumer space led him to co-found dotkonnekt, amid the COVID-19 pandemic, with a mission to turbo-charge growth for innovative brands in this Decade of D2C. He is currently building an Experiential Commerce platform through the convergence of Content, Community, and Commerce that allows brands to deliver a great experience, attract organic traffic, and convert from within the content and community engagement. With pay-it-forward philosophy at heart, Dhiraj mentors tech startups at NASSCOM Deeptech Club. Learn More about Dhiraj Jain and dotKonnektdotKonnektConnect with Steph Silver and the MVP podcast on:WebsiteInstagramLinkedinFacebook
Welcome to the Feel Good Podcast with Kimberly Snyder. My goal is to help you develop a holistic lifestyle based on Four Cornerstone philosophy - food, body, emotional wellbeing and spiritual growth. This holistic approach will help you feel good, which I define as being connected to your most authentic, highest self. And this is the place from which your energy, confidence, creativity, true power and true beauty will start to explode. Every week we provide you with interviews from top experts in their field or a solocast from yours truly to support you in living your most beautiful, healthy and joyful life. I'm your host, Kimberly Snyder. Founder of Solluna, New York Times bestselling author, holistic wellness & spiritual teacher.
In this episode you hear from Sandeep Jain, CEO & Co-Founder of MonetizeNow. This is a company that offers a unified CPQ, Billing and Usage Solution for B2B SaaS businesses in the tech industry. Sandeep lives with his family in the San Francisco Bay Area and here he talks about their solution approach, their solution architecture, an investment they received, competitors they see, their focus on the P in CPQ and much more. web: www.monetizenow.io LinkedIn: https://www.linkedin.com/in/sandeeja/ email: Sandeep@monetizenow.io
Ajahn Brahmali discusses sutta 56 from the Majjhima Nikaya, the collection of middle-length discourses: Upali Sutta, "Discourse with Upali". "The Buddha disagrees with a Jain ascetic on the question of whether physical or mental deeds are more important. When he hears of this, the Jain disciple Upāli decides to visit the Buddha and refute him, and proceeds despite all warnings.", Sutta Central. Read MN56 on Sutta Central here. Please support the BSWA in making teachings available for free online via Patreon. To find and download more precious Dhamma teachings, visit the BSWA teachings page: https://bswa.org/teachings/, choose the teaching you want and click on the audio to open it up on Podbean.
Dreams are never static, they keep evolving, they keep changing - says our very "well read" guest of Discover Your SecondAct Podcast Episode 79, Mr. Ajay Jain, founder of Kunzum Books (formerly popular as Kunzum Travel Café). What made this conversation even more special was shooting at the beautiful Kunzum outlet in DT Mega Mall in DLF Phase 1, Gurgaon. It's a beautiful book café, where you actually don't pay for your coffee; all Ajay wants everyone to do is to read at least 30 minutes a day, and he says magic will follow. Ajay's life has been of various acts, and each act was challenging but it really evolved him as a person. He very confidently says that if one does not experiment, how will we embrace failures and grow from there, and discover the hidden second act and various acts rather! When the intention is right to create Kunzum as a space for people's growth, this initiative is unstoppable. Coming from a person who is thoughtful, believes in conscious living and is already ready for another act this conversation is definitely inspiring. --- Send in a voice message: https://anchor.fm/iiact/message
Aligarh Muslim University was the principal institution that fostered separatism among Indian Muslims. Created for providing English model of education to the Muslim elites, it led in creating the separatist doctrine of two nation theory and also in activism on the ground. Prof. MP Jain discusses AMU's epicentric contribution to India's partition.
Aviator is a suite of tools to avoid broken builds, manage stacked PRs, simplify cumbersome merge processes, and suppress flaky tests. Ankit Jain, Co-Founder and CEO at Aviator, joins us to talk about his experience leading high-growth teams, how Aviator is improving engineering productivity for teams, and more. Links https://www.aviator.co https://twitter.com/ankitxg https://twitter.com/Aviatorco Tell us what you think of PodRocket We want to hear from you! We want to know what you love and hate about the podcast. What do you want to hear more about? Who do you want to see on the show? Our producers want to know, and if you talk with us, we'll send you a $25 gift card! If you're interested, schedule a call with us (https://podrocket.logrocket.com/contact-us) or you can email producer Kate Trahan at firstname.lastname@example.org (mailto:email@example.com) Follow us. Get free stickers. Follow us on Apple Podcasts, fill out this form (https://podrocket.logrocket.com/get-podrocket-stickers), and we'll send you free PodRocket stickers! What does LogRocket do? LogRocket combines frontend monitoring, product analytics, and session replay to help software teams deliver the ideal product experience. Try LogRocket for free today. (https://logrocket.com/signup/?pdr) Special Guest: Ankit Jain.
FRIENDS AND ENEMIES Thanks for coming back for another episode of The Canadian Bitcoiners Podcast. Powered by Shakepay! Receive $30 CAD on your first deposit of $100 CAD. Shakepay is the service we use to buy Bitcoin, and there isn't an easier way to start your stack! And Ledn.io! We use Ledn as a way to earn a nice chunk of Bitcoin interest on our BTC, and they offer loans, B2X and other services as well - check them out! Earn 10 USDC when you deposit and hold a minimum of 75 USDC or 150K satoshis! This week we sat down with Ritesh Jain, co-founder of Pine Tree Macro, for an in depth discussion on the Canadian economy - we touch on real estate, immigration, monetary policy, GDP per capita issues, and much, much more. Ritesh was an outstanding guest, and we're looking forward to having him on again - you can follow him on Twitter @riteshmjn, or check out his long-form writing on LinkedIn. Take care, and have a great weekend. --- Send in a voice message: https://anchor.fm/canadian-bitcoiners/message
On this episode we are joined by Christopher Jain Miller, the co-founder and Vice President of Academic Affairs of Arihanta Academy, a Jain Dharma college. He completed his Ph.D. in the study of Religion at the University of California, Davis and is the academic advisor for the global Jain Vegan Initiative. Chris and Hope dig deep into the parallel philosophies of Jain dharma and vegan living. They explore the concept of Ahimsa, Sanskrit for non-violence, and how young Jains are seeing veganism as a way to practice their principle of non-harming in a modern context. They also discuss Arihanta Academy, a new online Jain college, and Hope's class in starting Sept 24 called Ahimsa, Animal Advocacy and Veganism.Resources:Arihanta AcademyHope's Class- Ahimsa, Animal Advocacy, and Veganism Chris' Classes- Jain Philosophy in Daily Life, Yoga Sūtra: The Classical Yoga of PatañjaliInstagram- @thejainveganinitiative
My guest this month is Mr Prakrit, Andrew Ollett, who teaches at the University of Chicago Perhaps his most well-known publication is the book 'Language of the Snakes', which you can download for free here.Among his teachers were Eleanor Dickey, Gary Tubb and Sheldon Pollock (whose book 'The Language of the Gods in the World of Men' Andrew mentions)He talks about his work comparing the language of Theocritus with that of Prakrit poetry, about the work of Mātṛceṭa and Aśvaghoṣa , about the rock inscription of Rudradāman, and the influence that the Sātavāhana courts had on Prakrit. Among the languages and language forms he mentions are Vedic, Pali, Apabhraṃśa, Gāndhārī and Old Gujarati or Rajasthāni . Among the Prakrit texts he talks about are the Gaha Sattasai (and its recent translation by Khoroche and Tieken), the Setubandha, the works of Kundakunda, the Rasikaprakāśana by Vairocana, the Jain niryuktis ascribed to Bhadrabāhu, and the use of Prakrit in Sanskrit plays.You can find out a little more about Madhav Deshpande's book Sanskrit and Prakrit: Sociolinguistic Issues here.For his Sanskrit Studies Podcast Research Grant Project, Andrew will work on Kannada. He recommends A. K. Ramanujan's Speaking of Śiva, the Daśakumāracarita in Isabelle Onians' translation, Tamil Sangam poetry and especially the Kuruntokai, and suggests you go read Bhavabūti's Uttararāmacarita right now. (And I apologize for the sounds of my cat beating up his toys in the background!)
This episode with Felipe Jain, M.D. is so full of amazing things, it's hard to know how to describe all that you'll hear. Felipe did the Hoffman Process when he was twenty-five. He was in his third year as a medical student at Harvard Medical School. He was driven and ambitious, but found relationships to be a challenge for him. One of the wonderful moments Felipe remembers from his Process is when his emotional self finally got to speak up for himself and stand up to his intellect. He shares how amazing it was to just experience the magic of this child within himself - a child who is wonderful, beautiful, and fun. Now, many years later, Felipe is a Psychiatrist, a Researcher, a Neuroscientist, and a Professor at Harvard Medical School. As you'll hear in this episode, Felipe, through the Process, found and continues to develop a beautiful balance between all four aspects of his Quadrinity. He also has been able to use aspects of his Process experience as well as some of what he learned there in his work as a Psychiatrist. One magical part of this episode is how Felipe describes his experience of Being. A meditator for over thirty years (he started at age 13 or 14), he has deepened his relationship with people and nature by coming to know how to shift perspectives and learn to truly take in what another is experiencing. Felipe describes the evolution of Being and the nature of Being through metaphor and physics. You've got to listen to and feel what he shares. Be sure to take time to discover more about Felipe's work and the resources he's made available to us all. More About Dr. Felipe Jain, M.D.: Originally from San Rafael, CA, Dr. Felipe Jain, M.D., is Director of Healthy Aging Studies at the Depression Clinical Research Program of the Massachusetts General Hospital in Boston. His research group aims to develop new guided imagery and mindfulness tools for people caring for loved ones with chronic illness. Additionally, his lab studies objective brain connectivity, stress hormones, and other biological markers of psychotherapy treatment. This research is funded by competitive grants from the National Institutes of Health and private foundations. Dr. Jain also treats patients – predominantly with treatment-resistant depression – in private practice. He is an Assistant Professor of Psychiatry at Harvard Medical School. Felipe teaches medical students tools for resilience and serves on the MD Advisory Board of the Harvard-MIT Division of Health Sciences and Technology. He also supervises psychiatry trainees in the number one ranked Massachusetts General Hospital-McLean psychiatry residency program. Dr. Jain's most recent endeavors include studying smartphone delivery of psychotherapy, researching brain activity occasioned by psychedelics, writing a book on guided imagery and mindfulness, and creating a startup based on his mobile application platform development. When not working, he enjoys meditating, crafting poetry, reading sci-fi, playing tennis with his two children (ages 7 and 9), hiking in the Middlesex Fells, and laughing for no reason on his back porch. Dr. Jain is also a Hoffman Institute Foundation Board Member. We are grateful for his willingness to share his expertise, experience, and love to further Hoffman's goal of bringing peace to the world one person at a time. As mentioned in this episode: 14 Billion years: the age of the Universe Quark: "A quark (/kwɔːrk, kwɑːrk/) is a type of elementary particle and a fundamental constituent of matter." Wikipedia Lao Tzu (or Laozi): 6th-century BC ancient Chinese philosopher and writer Lao Tzu, is believed to be the author of the Tao Te Ching. He is also "the founder of philosophical Taoism and a deity in religious Taoism and traditional Chinese religions." Wikipedia The Tao Te Ching: "The Tao Te Ching, along with the Zhuangzi, is a fundamental text for both philosophical and religious Taoism." Wikipedia FernHillCenter.org:
Rishabh is the co-founder and CEO of Fermat Commerce, a distributed commerce platform built to enable creators to embed brand direct shopping experiences on their own sites. Prior to that he was an executive at LiveRamp (NYSE:RAMP), where he led the new business teams, successfully launching 3 new businesses inside of LiveRamp. Before LiveRamp he co-founded 2 startups, one in solar energy, and the other in laboratory data sharing. He graduated Summa Cum Laude from UPenn with degrees from Wharton and the Engineering school, a Masters in Physics from Imperial College London, and a PhD in Materials Science from MIT. On this episode we discussed: Benefits of a brand-direct shopping experience Creating immersive retail experiences How brands should approach customer acquisition Tips for creating brand partnerships Get started with Fermat commerce: https://www.fermatcommerce.com/ Schedule a call now to get your startup podcasting system: https://calendly.com/thecoachchris/startup-podcasting Learn more about your ad choices. Visit megaphone.fm/adchoices
Nicole Jain has dedicated her career to public service and leadership, specifically in the realm of K-12 public education policy and management. Most recently, Nicole co-authored "Our Mom, Our Superhero - A Mental Health Journey," a children's book that provides young children with early education and tools to understand, identify, destigmatize, and manage mental health struggles from a young age. Nicole is also on the board of directors of the Pad Project, a non-profit organization focused on worldwide reproductive health. In this week's of the Liberty and Leadership Podcast, Roger and Nicole discuss her TFAS experience, the power of philanthropy, the future of education in America, and the story behind her book. The Liberty and Leadership Podcast is hosted by TFAS President Roger Ream (https://tfas.org/podcast) and produced by kglobal (https://kglobal.com/podcast-studio). If you have a comment or question for the show, please drop us an email at podcast@TFAS.org.Support the show
Season 5 Episode 22: In this episode, I interview Tarun Jain who is a Philatelist and a Numismatist. We talk about the importance of his collection and how to start a collection.Follow my Facebook page to get updates on upcoming episodes. https://www.facebook.com/curiousvedanth/To listen to earlier episodes, visit curiousvedanth.comTo listen at leisure on your phone and get notified about future episodes, subscribe by searching for 'Curious Vedanth' wherever you get podcasts, such as Apple Podcast, Stitcher, Google Podcast, Spotify, etc.
As the hearing on the maintainability of the Gyanvapi suit as regards its maintainability concluded today in the District Judge's Court, all eyes are now on 12th September. Vishnu Jain refuted all the arguments of the Muslim side. Sanjay Dixit explains.
In this episode, host Shikha Jain, MD, speaks with Ragy Girgis, MD, MS, about findings from the Columbia Mass Murder Database he co-developed, the associations between mental illness and mass shootings and more. Content Warning: This episode contains discussions of gun violence and suicide. Listener discretion is advised. Welcome to another exciting episode of Oncology Overdrive :14 About Girgis :24 The interview: 1:51 How did you find yourself working in psychiatry, and specifically, in the field of looking at mass murders and gun violence? 2:04 Do you have any thoughts on mental health in the US vs. other countries? How do you address people who give that rhetoric when they talk about these scenarios? 4:27 Why create this database? ... What do we learn from this type of work? 5:26 Why do you think people commit mass murder with guns? 8:17 Do you have any thoughts as to why we're seeing more of these happening now than we did in the past? 11:05 Is there any data or difference in violence committed by women vs. men, and whether they are more likely to be prone to violence or more likely to execute a mass shooting event? 13:11 What do we need to do make these changes and advocate for this? … How do we take this data, this information, and then move on it? 17:29 Is there hope for the future when we talk about these things? … Looking at the data, is this something that we can strive for or may change? 21:03 What are your future plans for this type of work and your research? What are you thinking the next steps are going to be? 26:48 If someone could only listen to 2 minutes of this episode, what would you want them to take away? 29:14 How to contact Girgis 30:10 Thanks for listening 31:14 References: Brucato G, et al. Psychol Med. 2021;doi:10.1017/S0033291721000076. Ragi Girgis, MD, MS, is associate professor of clinical psychiatry at the Columbia University Department of Psychiatry and New York State Psychiatric Institute. We'd love to hear from you! Send your comments/questions to Dr. Jain at firstname.lastname@example.org. Follow us on Twitter @HemOncToday and @ShikhaJainMD. Girgis can be reached by searching Ragy Girgis on Columbia University's website. Disclosures: Jain reports no relevant financial disclosures. Girgis reports he is a paid consultant for IMS Expert Services, a paid consultant for Noble Insights research firm, and receives royalties from Wipf and Stock Book.
Make sure you have a single problem that you are focused on at any given point in time and treat it as existential. It is just what is the single thing that is the most critical for your business at this point in time and actually worry about that one thing and then move on to the next thing. It is the behavior that could be the most useful. --- Send in a voice message: https://anchor.fm/the-inventive-journey/message
Prateek Jain, is our friendly Network Capital Rocket Scientist. He designed Business jets for years before, two tech startups and an MBA at Columbia Business School led him to Product Management. He now lives in San Francisco, and does Product Management at the Hypergrowth company - Twilio. Prateek is passionate about building technology, writing, and simplifying complex ideas to make an impact. Lately, he's trying to meditate more and perfect his Hakka Noodles recipe.
Today I'm chatting with Kelly Ann Peck all about sales scripts that work every time. Kelly and I go over what is a sales script, why is it important, and how to use them in your sales call starting today. A little bit about Kelly is that she is the Founder of Emerson Reese Creative and is committed to helping event entrepreneurs create their own path in life by translating her experience into actionable strategies that turn ideas into profitable businesses. She has made it her personal mission to give back to the event industry by helping business owners avoid the mistakes she made and, ultimately, reach their full potential. Visit Website: https://emersonreesecreative.com Instagram: https://www.instagram.com/emersonreesecreative Facebook:https://www.facebook.com/emersonreesecreative LinkedIn: https://www.linkedin.com/in/kellyannpeck Podcast Sponsor - Pixpa Pixpa is an all-in-one platform for creators and small businesses to create beautiful professional websites. Whether you want to showcase your portfolio, start your business website, set up your online store, or publish a blog - Pixpa empowers creators to manage their whole web presence from one location, saving time and money. With a host of built-in tools such as an Online Store, Blog, SEO Manager, Marketing Pop-Ups, Announcement Bar, and much more, Pixpa offers you all the tools you need to start growing your business online. Pixpa's affordable, all-inclusive plans start at just $7/month and come with 24/7 support, unlimited bandwidth, SSLs, and much more. Start building your website with Pixpa's 15-day full-featured, free trial. Tea with Jainé listeners get a special 50% Discount. Use code TEAWITHJAINE when you subscribe. Love the podcast? Please leave a 5 ⭐️ review on Apple Podcasts. Our Investment Guide Template for Wedding Photographers is available in our online shop. Need help submitting your wedding to publications? We offer 1:1 and Done for You Wedding Curations + Submission Services - click here to book your spot today! Get our Wedding Submissions E-Mail Templates to help make your next online or print submission easier! Stay Connected: Follow @teawithjaine & @jainekershner on Instagram We are looking for Sponsors just like you! Visit Our Website to Apply: www.teawithjaine.com
Teen Innovator's New AI Tool Helps Create Affordable Drugs The U.S. has some of the highest prescription drug prices in the world, which can push patients into bankruptcy over medications they cannot afford. More than three in four American adults think the prices of prescription drugs are unaffordable, prompting the Senate to recently pass a bill intended to help lower prescription drug costs for seniors. One young innovator set out to find his own solution. 17 year-old Rishab Jain developed ICOR, a tool to improve the rapid production of drugs like COVID-19 vaccines. Ira talks with Jain from Portland, Oregon, about his innovation and vision for the future. When Trapping Invasive Bugs Is Science Homework The spotted lanternfly, an invasive species, was first introduced to the U.S. in Pennsylvania, around 2014. Since then, it has spread aggressively, and has now been spotted in 11 states. The bug is pretty—adult spotted lanternflies are about an inch long, and feature striking spotted forewings and a flashy red patch on the hindwings. But they are also very hungry, and pose a significant threat to agricultural crops, including grapevines. Many control efforts have focused on either stomping the insects on sight, or on spotting and destroying the egg masses that the lanternflies lay in the fall. However, researchers have been developing trapping techniques for the bugs as well. One, involving a sticky band looped around a tree, is effective—but can also snare other insects and even birds. Experts at the Penn State Extension have come up with a new style of circle trap for lanternflies, based upon an existing trap for pecan weevils. Now, STEM educators at Rutgers University are using that design as the starting point for an engineering design challenge, asking K-12 teachers and students to come up with improvements to the design. Read the rest at sciencefriday.com. Should Kids Get Vaccinated If They've Already Had COVID-19? It's nearing the end of August, which means it's back-to-school season. There's a big difference between this school year and last: All children are now eligible for the COVID-19 vaccine. This means the risk of disease will likely be way down, compared to the past two autumns, according to vaccine researcher and pediatrician Paul Offit. But for kids who have already been infected by COVID-19, will the vaccine add meaningful immunity? “My answer to that question is yes,” Dr. Offit tells Ira. “Then you can be sure that they will then develop the kind of immunity that will likely lead to fairly long-lived protection against serious illness.” Ira and Dr. Offit also discuss the risk of monkeypox and polio spreading in schools, and how to best keep our kids safe against infectious disease this fall. The Countdown Begins For Humanity's Return To The Moon NASA's largest and most powerful rocket ever began inching its way to Launch Pad 39B at Kennedy Space Center in Florida on Tuesday night. Over twelve years in the making, the long-delayed, over-budget Space Launch System rocket is finally nearing its first chance for liftoff at the end of this month. The August 29th targeted launch will mark the beginning of the Artemis program—NASA's series of missions designed to send humans to the Moon and, eventually, Mars. The multi-billion dollar orange rocket now stands taller than the Statue of Liberty, resembling a colossal upside-down carrot. Its maiden uncrewed flight will carry a trio of mannequins equipped with radiation sensor vests in preparation for crewed flights slated for 2024. These future missions will be the first to return people to the Moon since Apollo 17 in 1972. Read the rest at sciencefriday.com. Transcripts for each segment will be available the week after the show airs on sciencefriday.com.
In this episode, Tanmay Mathur and Abhishek Jain join us to discuss engineering diabetes with personalized and vascularized organ-chips. Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe! https://thesugarscience.org/ask-the-expert/
About our Guest: Priyanka Jain of Evvy Women weren't required to be included in U.S. clinical trials until 1993, meaning we don't know nearly as much about their bodies as we do about men's bodies. Evvy is working to change that. Priyanka Jain is the Co-Founder & CEO of Evvy. Evvy is on a mission to radically reinvent how we understand and treat the female body, starting with the vaginal microbiome. Evvy's first product — the Evvy Vaginal Health Test — is the first-ever at-home vaginal microbiome test to use metagenomic sequencing to tell you what's up down there, why it matters, and what you can do about it.
This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. Article highlights: Jain, et al. Role of UPR in Platelets Orlich et al: SRF Function in Mural Cells of the CNS Xue et al: Gut Microbial IPA Inhibits Atherosclerosis Wang et al: Endothelial ETS1 on Heart Development Cindy St. Hilaire: Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function. They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients. Cindy St. Hilaire: The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics. To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning. Cindy St. Hilaire: The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity. This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression. Cindy St. Hilaire: The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known. Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects. Cindy St. Hilaire: Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today. Annet Kirabo: Yeah, thank you so much for having us. Ashley Pitzer: Yeah, thank you for having us. Cindy St. Hilaire: Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis. Annet Kirabo: Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension. Annet Kirabo: We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation. So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process. Cindy St. Hilaire: That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others. Annet Kirabo: Yeah. Cindy St. Hilaire: What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive? Annet Kirabo: Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up. Cindy St. Hilaire: Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day? Annet Kirabo: Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table. Cindy St. Hilaire: Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background? Ashley Pitzer: No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people. Cindy St. Hilaire: I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things. Cindy St. Hilaire: What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening? Ashley Pitzer: That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney. Annet Kirabo: Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney. We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension. Cindy St. Hilaire: Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype? Annet Kirabo: That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach. Cindy St. Hilaire: Always smart. Annet Kirabo: Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different. The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans. Cindy St. Hilaire: And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work? Ashley Pitzer: That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them. Cindy St. Hilaire: How much is a salt load? Like a Big Mac? What's a salt load? Ashley Pitzer: Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal. Annet Kirabo: And then in addition, we also infuse saline too. Cindy St. Hilaire: Oh, wow. Annet Kirabo: Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead. Ashley Pitzer: With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data. Cindy St. Hilaire: How long did it take you to sort through? Ashley Pitzer: Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta. Annet Kirabo: As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression. Annet Kirabo: We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients. Cindy St. Hilaire: This was samples obviously taken from a blood draw, right? So they're circulating. Annet Kirabo: It was a blood draw, yes. Cindy St. Hilaire: What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think? Annet Kirabo: When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most. Cindy St. Hilaire: You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential? Ashley Pitzer: Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor. Ashley Pitzer: So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that. Annet Kirabo: To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent. As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people. So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension? Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs. Cindy St. Hilaire: What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part? Ashley Pitzer: You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it. Ashley Pitzer: Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea. Annet Kirabo: I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them. Cindy St. Hilaire: Yeah. Annet Kirabo: They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone. Annet Kirabo: Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up. Cindy St. Hilaire: So, what's next? What's the next question? Annet Kirabo: We have so many. Cindy St. Hilaire: That means it was a great study. If you have more, that means it was a great study. Annet Kirabo: Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that. Cindy St. Hilaire: Yeah, very cool. Annet Kirabo: Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating. Cindy St. Hilaire: It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta. Annet Kirabo: Thank you. Thank you so much. Ashley Pitzer: Thank you for having us. Cindy St. Hilaire: That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.
We use our smartphones to communicate, shop, navigate, watch videos, take pictures, share our lives on social media, track our exercise, and listen to music and podcasts. So why shouldn't they also be the main interface to our healthcare experiences? That's the question P.J. Jain started out with in 2010 when he left behind a career in networking and telecommunications to start a company dedicated to mobile health. Called Vibrent Health, the company went on to win a game-changing contract in 2015 to help the National Institutes of Health build a mobile data-gathering infrastructure for a giant research program called All of Us.That's a 10-year project designed to gather medical data from more than a million people around the United States to help doctors make more customized health recommendations based on a patient's environment, lifestyle, family history, and genetic makeup. If you're going to try to recruit a million people into your research study and keep tabs on their health, and if those people are going to be from diverse backgrounds, and if they're going to be distributed around the country, then there's only one practical way to reach them, and that's on their smartphones. NIH asked Vibrent to build a mobile app and an online portal that would become the communications backbone and the central data gathering repository for the whole project. And now that NIH is six or seven years into the All of Us project, it's clear that in some ways the project, and Vibrent's front end, have leapfrogged over the rest of the US healthcare ecosystem. The app provides an easy way to gather and manage data from patients in the study, and to monitor and interact with them, while still protecting their privacy. As Jain puts it, it meets All of Us participants "where they are" – meaning, on their phones. Technology like that still isn't part of the offering at most big health plans or hospital networks. But Vibrent is working to change that by partnering with health systems, academic health centers, pharmaceutical companies, public health organizations, and research organizations to get its mobile apps distributed more widely. If you believe that our phones are going to be a key element of personalized and precision medicine for everyone, then the work Vibrent is doing with NIH and its other customers is worth watching.For a full transcript of this episode, please visit our episode page at http://www.glorikian.com/podcast Please rate and review The Harry Glorikian Show on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:1. Open the Podcasts app on your iPhone, iPad, or Mac. 2. Navigate to The Harry Glorikian Show podcast. You can find it by searching for it or selecting it from your library. Just note that you'll have to go to the series page which shows all the episodes, not just the page for a single episode.3. Scroll down to find the subhead titled "Ratings & Reviews."4. Under one of the highlighted reviews, select "Write a Review."5. Next, select a star rating at the top — you have the option of choosing between one and five stars. 6. Using the text box at the top, write a title for your review. Then, in the lower text box, write your review. Your review can be up to 300 words long.7. Once you've finished, select "Send" or "Save" in the top-right corner. 8. If you've never left a podcast review before, enter a nickname. Your nickname will be displayed next to any reviews you leave from here on out. 9. After selecting a nickname, tap OK. Your review may not be immediately visible.That's it! Thanks so much.
Christopher Jain Miller is the VP of Academic Affairs and Professor of Jain and Yoga Studies at Arihanta Academy. He completed his Ph.D. in the study of Religion at the University of California, Davis, and his current research focuses on applied Jain dharma and the ways by which Jain principles can be lived in daily life. Christopher is the author of a number of articles and book chapters concerned with Jain dharma, Jain veganism, the history and practice of modern yoga, yoga and politics, and yoga philosophy and is a co-editor of the volume Beacons of Dharma: Spiritual Exemplars for the Modern Age (Lexington 2019). He lectures internationally on Jain and yoga topics and is a certified continuing education provider for the Yoga Alliance. He is the academic advisor for the global Jain Vegan Initiative to promote a vegan lifestyle in light of the Jain principles of non-violence, compassion, and karma.In this episode Yoga is Vegan's Holly Skodis and Christopher Jain Miller discuss the following:Ahimsa and its role in both Yoga and the Jain religion. History of contemporary JainismKarma and its relationship to samskarasHatha Yoga Pradipika Jain Vegan InitativeArihanta AcademyConnect with Christopher Jain Miller:Instagram: @theyogaprofessorFacebook: @ChristopherJainMillerWebsite: arihanta-academy.com Fall 2022 Classes:Ahimsa, Animal Advocacy, and Veganism with Hope BohanecBeyond Vegetarianism: Jain Veganism and the Promotion of Ahimsa - Nisha Mehta, Pratik Bhansali, Sunny Jain Modern Yoga Studies: Critical History, Anthropology and Methodology- Professor Christopher Jain Miller, PhD