Podcasts about Wharton

In Part Two of our series on the dark history of Wharton County, we examine three more haunting cases that continue to leave families searching for answers.The episode begins in Ganado, Texas, with the unsolved 1999 murder of beloved English teacher Jean Schoeneberg. A respected educator known for her high standards and daily morning walks, Jean was found brutally murdered along a quiet rural road near her home. Despite decades of investigation, DNA testing, and renewed leads, her killer has never been identified.Next, we explore the 2014 disappearance of Mitchelle Deborah Hicks, a 25-year-old mother of two who vanished after leaving a residence in Wharton. Investigators believe she may have been taken against her will, but more than a decade later, few details have been released publicly, and her family is still waiting for answers.Finally, we follow the remarkable identification of Wharton County Jane Doe, whose skeletal remains were discovered in a remote field in 2021. For four years she had no name, until advances in forensic genetic genealogy revealed she was sixteen-year-old Yeimy Maciela Beltrand. Her identification led investigators to name a suspect in her murder, but he fled before he could be arrested and remains a fugitive.These cases span more than twenty-five years, yet they share the same painful reality: families whose lives were forever changed, investigations that remain incomplete, and the enduring hope that someone, somewhere, still knows the truth.If you have any information about the murder of Jean Schoeneberg or the whereabouts of Luis Omar Beltran-Mendoza, suspected in the murder of Yeimy Maciela Beltrand, please contact the Wharton County Sheriff's Office at (979) 532-1550.If you have any information about the disappearance of Mitchelle Deborah Hicks, please call the Wharton Police Department at (979) 532-3131.You can support gone cold and listen to the show ad-free at https://patreon.com/gonecoldpodcastFind us at https://www.gonecold.comFor Gone Cold merch, visit https://gonecold.dashery.comFollow gone cold on Facebook, Instagram, Threads, TikTok, YouTube, and X. Search @gonecoldpodcast at all or just click https://linknbio.com/gonecoldpodcast#JusticeForJeanSchoeneberg #JusticeForYeimyBeltrand #WhereIsMitchelleHicks #WhartonCoTX #Texas #TX #TexasTrueCrime #DarkHistory #ColdCase #TrueCrimePodcast #Podcast #Unsolved #MissingPerson #Missing #Disappeared #Disappearance #Vanished #Murder #UnsolvedMurder #UnsolvedMysteries #Homicide #CrimeStories #PodcastRecommendations #CrimeJunkie #MysteryPodcastBecome a supporter of this podcast: https://www.spreaker.com/podcast/gone-cold-texas-true-crime--3203003/support.

For more than 150 years, Wharton County, Texas, has been shaped by both prosperity and violence. In the first installment of this special series, we trace the county's darker history: from racial terror and vigilante justice in the late nineteenth and early twentieth centuries to two heartbreaking crimes in modern times that forever changed the community.In 1988, 24-year-old Juana Velasquez Moreno was brutally murdered while opening the Kwik Chek convenience store where she worked. For decades, her family believed the investigation had simply gone cold, only to later discover that a suspect had twice been indicted for her murder without their knowledge.Just over two years later, fifteen-year-old Rosemary Diaz vanished while working alone at a small country store in Danevang. Twenty-five years passed before long-hidden secrets led investigators to her grave, finally revealing what happened on the night she disappeared.This episode explores how violence has echoed across generations in Wharton County, where justice has never necessarily prevailed, sometimes failed, and sometimes arrived far too late.If you have any information about the murder of Sanjuana Velasquez Moreno, please contact the Wharton County Sheriff's Office at (979) 532-1550.You can support gone cold and listen to the show ad-free at https://patreon.com/gonecoldpodcastFind us at https://www.gonecold.comFor Gone Cold merch, visit https://gonecold.dashery.com Follow gone cold on Facebook, Instagram, Threads, TikTok, YouTube, and X. Search @gonecoldpodcast at all or just click https://linknbio.com/gonecoldpodcast#JusticeForSanjuanaVelasquezMoreno #WhartonCoTX #Texas #TX #TexasTrueCrime #DarkHistory #ColdCase #TrueCrimePodcast #Podcast #Unsolved #MissingPerson #Missing #Disappeared #Disappearance #Vanished #Murder #UnsolvedMurder #UnsolvedMysteries #Homicide #CrimeStories #PodcastRecommendations #CrimeJunkie #MysteryPodcastBecome a supporter of this podcast: https://www.spreaker.com/podcast/gone-cold-texas-true-crime--3203003/support.

We dig into misconceptions and truths about the true cost of an MBA abroad.

How are you using your relationships to discover yourself? This week, Joey and Jess talk about the Johari Window, observation, employee reviews, dudes not knowing about dudes, blind spots, and centipedes. They don't talk about Professor Joseph Harrington at Wharton. references Johari Window Human Relations Training News: 1961 published article on Johari Window 

In this episode, I sit down with Paul Hynek — entrepreneur, futurist, Wharton MBA, and Adjunct Professor of Finance at Pepperdine University. Paul is the son of legendary astronomer and UFO researcher Dr. J. Allen Hynek, creator of the Close Encounter classification system and the real figure behind History Channel's Project Blue Book. Paul has built a remarkable career of his own at the cutting edge of technology, cryptocurrency, virtual production, and startups — including playing a key role in the sale of Giant Studios to James Cameron for Avatar, launching the world's first children's online service with Bill Gates, and creating EZ Numbers, the financial projections software that has raised over $1 billion for thousands of startups. A frequent speaker at South by Southwest, Harvard, and Wharton, Paul is also a pioneering longevity researcher — one of the first people in the world to regrow his thymus gland in an FDA-approved life extension trial. Woven through all of it is a lifelong fascination with UFOs, DMT, consciousness, and the nature of reality — a path that led him, in his own words, to believe that disclosure won't come from a government podium, but from direct experience itself. If this conversation resonates, like, comment, and subscribe. Support the show: Patreon - https://www.patreon.com/dangothoughts Code of Reality (COR) - https://codeofreality.org/ Connect with Danny Goler: Website - https://dannygoler.com/ TikTok - https://www.tiktok.com/@dannygoler Instagram - https://www.instagram.com/dannygoler/ X - https://x.com/golerdanny?s=21&t=Gjcrl3ekQAHfVmhYl1OXzA Substack - https://dannygoler.substack.com/ Facebook - https://www.facebook.com/danny.goler/ Facebook COR Professional page - https://www.facebook.com/profile.php?id=61586952941889 COR Website - https://codeofreality.org/ YouTube Link - https://youtu.be/ZZWGbdli8ZU Connect with Paul Hynek: X - @paulhynek #UFO #Disclosure #DMT #AIsingularity #Consciousness #ProjectBlueBook #Psychedelics #Bitcoin Learn more about your ad choices. Visit megaphone.fm/adchoices

Spurs Chat: Discussing all Things Tottenham Hotspur: Hosted by Chris Cowlin: The Daily Tottenham/Spurs Podcast Hosted on Acast. See acast.com/privacy for more information.

Spurs Chat: Discussing all Things Tottenham Hotspur: Hosted by Chris Cowlin: The Daily Tottenham/Spurs Podcast Hosted on Acast. See acast.com/privacy for more information.

Sandro Tonali to Spurs has split the fanbase. Is he the deep-lying playmaker we've been crying out for? Or is he a £100m Bentancur replacement? In this week's Scouting Room, Enya Collins (data) and JJ (eye test, A-licence coach) break Tonali down on every metric that matters and answer the question the rest of Spurs YouTube isn't quite getting to. The verdict: Tonali is half of the midfield rebuild. Without a Stiller-or-Wharton signing to follow, the squad still has the same problem it had before. Plus: Enya's contrarian close on the squad building, and Jim's ruthless take on what Spurs need to stop being sentimental about. #KeepItLilyWhite #OhSo33 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Afternoon all,Time to go through all your latest Chelsea summer transfer news and MUCH more! Got some World Cup chatter in this too.Enjoy!Si&Jai This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sptc.news/subscribe

This week we talk test waivers, optional essays, and how big-ticket charitable gifts shape scholarship funding.

Finally, a Knick ticker-tape parade. A wild rescue in Wharton NJ. Learn more about your ad choices. Visit megaphone.fm/adchoices

I recorded this episode in the middle of one of the most emotional weeks of my life. My daughter Cora was three days from graduating high school, and I found myself at backyard parties where the conversation kept drifting to the same familiar places: the weather, work, the kids.And I felt that quiet ache I believe so many of us are carrying right now. The longing for something deeper. More real. More connected.So that's what today's episode is about: how we find the courage to have more connection.Something Is ShiftingBecause I think we all feel it. This quiet ache underneath the busyness of our lives. We reach for our phones in line for coffee instead of turning to the person next to us. We text instead of call. We scroll instead of sit. We show up to gatherings and perform a version of ourselves the edited, polished, “I'm fine” version instead of actually arriving in all our beautiful messiness.And from this? We feel less connected. More lonely. More invisible.Here's what I've learned in 25 years as a therapist: loneliness isn't about being alone. You can be surrounded by people at a party, in a marriage, in an office full of colleagues and still feel profoundly unseen. The opposite of loneliness isn't proximity. It's depth.And the data tells us loneliness is worse for your health than smoking, obesity, or high blood pressure. Anxiety and depression are the highest ever, and we are more likely to die from feeling lonely. The epidemic is real.But here's what I know after 25 years of sitting with people in my office: loneliness is not the problem. It's the symptom. Connection is the medicine. And the prescription? COURAGE.The courage to ask a real question. To say the true thing. To let someone love you back. So here are the four pillars of courage to create more connection and therefore more LOVE.The Four Pillars of Courage for Connection✨1. Ask for HelpHere's the thing about asking for help: we avoid it because we think it makes us look weak or like a burden. A Harvard and Wharton study found the number one reason people don't ask for help: it makes us feel incompetent.But here's what the research actually shows. When you ask someone for help, they see you as more competent. They trust you more. And this is the part I love so much: they feel like they matter.I have been a therapist for decades, and I still feel resistance every single time I walk into my own therapist's office. But this week, in the middle of all the graduation chaos, I asked a couple of friends for help. And I felt the weight lift. I wasn't just giving love anymore. I was letting people give me love back.Next time someone asks how you're doing, try this instead of “fine”:“I've been wrestling with something lately. Can I get your take on it?”“Honestly, I could use some advice. I've been dealing with something hard.”Watch what happens to their face. Watch their eyes change. You just told them they have something real to offer you. You just allowed them to love you.✨2. Be AuthenticI know authenticity gets thrown around so much it almost loses its meaning. So here's what I actually mean by it: tell the truth. Not the highlight reel, not the LinkedIn version. The real one.I was on a walk with a dear friend recently, and I could feel she'd been carrying something heavy for months. I kept holding back, not wanting to push. But finally I said: “I see something going on with you. I feel like you're carrying something hard. Can I be here for you?”She was honest. She cried. And then I could share my own fears about Cora leaving for college. We walked away closer than we'd been in years.Try slipping one of these into your next conversation:“What's been the hardest part of your week?”“If you're being totally honest, how are you?”People might pause. It might get a little uncomfortable. The Buddhists teach that we need to get comfortable with the uncomfortable.✨3. Make ChangeYes, the world is noisy. Yes, our phones, schedules, and the general chaos of life are real. But we still get to choose where we spend our time and if we want to connect on a deeper level.It is our responsibility to create the rituals, the invitations, the conversations for more connection. A month ago I challenged myself to walk up to a table of strangers, young, hip, athletic mountain bikers, and ask if they'd be on my podcast. My heart was pounding. But when I did, they looked up. They smiled. They felt seen.And at a graduation party recently, I stopped a new friend and said, “I'm challenging myself to go deeper at these parties. So here's my question: in a year from now, what do you want to be celebrating?”We both got quiet. Then she said: “I want to be celebrating that I don't worry as much. That I've let go of the weight I carry around my kids and my divorce. That I'm finally celebrating who I am.”That is the kind of conversation that stays with you. That's the one you remember.✨4. Be in Service: Show Up to See, Not Just to Be SeenMost of us walk into a room carrying some version of the same quiet anxiety: Do I look okay? Will people like me? Am I enough? You are not alone in that. I feel it every time too.But what if you walked in with just one question in your heart:“Who in this room needs to feel less alone today?”That is the shift. That is everything. When you become the person who asks the real questions, who listens without fixing, who makes eye contact and says “tell me more,” you become magnetic. Not because you performed well. Because you made someone feel like they mattered.Some of my favorite questions to bring to any gathering:“What's something you wish more people asked you about?”“What's the best thing that's happened to you in the last month?”“How do you want to live?”I heard that last one recently from a son speaking at his father's funeral. I haven't stopped thinking about it since.This Is the MomentWe keep waiting for the right time to have the real conversation. The right setting. The right moment. The right person to go first.There is no right time. This is the moment.By the time you read this, Cora has already graduated. The cap, the gown, the ugly crying it's all happened. And I can tell you that the conversations I will carry from this season are not the ones about the weather. They're the ones where someone looked me in the eye and asked something real.At your next gathering, be the one who goes first. Ask the brave question. Sit with the pause. Put down your phone and let it go somewhere.The world doesn't need more small talk. It needs more of you the real, brave, loving, beautifully messy, imperfect you.That is the magicxoLots of love, Molly 

Spurs' biggest gap isn't up front, it's the controller in midfield. Enya Collins ranks the five players who could fix it. After calling Van Hecke and Bohoya before either link broke, Enya turns to the deep-lying playmaker Tottenham haven't had in years. The five: Nico Gonzalez, Alex Garcia, Manuel Loccatelli, Angelo Stiller, Adam Wharton — and why one of them might quietly be the right answer over the obvious pick. Plus: why Enya took three weeks off watching Spurs last season. #KeepItLilyWhite #OhSo33 Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, Gies Business professor Eren Ahsen shares his unconventional journey from mathematics and electrical engineering to machine learning in healthcare and ultimately business education. He discusses how AI evolved from an academic pursuit into a transformative force in medicine and organizations, why combining multiple algorithms leads to better decisions, and how business leaders can thoughtfully integrate AI into real-world workflows. With insights on bias, human judgment, and the future of business schools, Eren makes the case for cross-disciplinary, human-centered AI that improves lives without removing the human touch.

Want help with your MBA applications? ⁠Book an MBAApplication Strategy Call.⁠ If you're new here, my name is Jahlen Brown. I'm a HarvardBusiness School student and former private equity analyst. I spent four years working in the industry, closed over $1 billion in transactions, and worked 80-hour weeks while building my MBA applications. Today, I create content to help ambitious professionals break into elite careers, earn admission to topbusiness schools, and create opportunities they never thought possible. How I got here... 20: Committed to breaking into private equity and became the first person in my family to work in finance21 yrs old: Finally broke into private equity and started myfirst internship at a real estate fund. Became involved with Sponsors for Educational Opportunity (SEO), helping underrepresented students break into competitive careers22 yrs old: Graduated Rutgers University Summa Cum Laude and landed three private equity job offers. Began my career in acquisitions in NYC 23 yrs old: Became the protégé of Joe Plumeri II, former CEOof Citibank, Willis Group, and Primerica24 yrs old: Private equity fund consolidated and learned Iwas getting shoved out. Experienced my first major setback and began searching for new opportunities25 yrs old: Started a new private equity role, signed myfirst M&A deal, and decided I wanted to create even bigger opportunities for myself. I began preparing for business school while working 80-hour weeks26 ys old: Accepted into 11 business schools, includingHarvard, Wharton, Columbia, Booth, and Dartmouth26 ys old: Earned approximately $910,000 in scholarships,including full-tuition scholarships to Cornell and Yale26 ys old: Became the first person in my family to attend anIvy League institution26 ys old: Achieved all of this despite having a low GMATscore while working 80-hour weeks Today: I'm attending Harvard Business School and documenting everything I learn about admissions, recruiting, entrepreneurship, investing, and career growth. I grew up in a lower-class family, attended communitycollege, transferred to Rutgers, worked my way into private equity, and eventually earned admission to the best business schools in the world. I was never the smartest applicant I just refused to quit after I got knocked down If you stick to your goals, you can do far more than youthink To everyone chasing a bigger future: Keep betting on yourself Keep moving Never quit JahlenFollow Jahlen's other platforms: ⁠YouTube⁠ | ⁠LinkedIn

Donny Deutsch breaks down the biggest brand winners and losers shaping culture right now in this week's Brands of the Week episode of On Brand with Donny Deutsch — the podcast where everything is a brand. This week Donny covers: college tuition hitting $100,000 at Duke, Georgetown, and Wash U — and what it means for the value of a college degree in the age of AI and trade careers. Amazon dethrones Walmart on the Fortune 500 after 13 years, signaling the definitive rise of e-commerce over brick-and-mortar retail. AI kills the cover letter — Wharton research confirms AI-generated applications have made cover letters meaningless for hiring managers. Clint Eastwood retires at 96 — a look back at one of Hollywood's greatest directing and acting legacies. Dwayne "The Rock" Johnson's Papatui cologne launches at Target — is a $40 celebrity fragrance a brand win or a miss? Harry Styles gives away free concert tickets to fans who volunteer through nonprofits on his Love on Tour residency. Acadia National Park tops Yellowstone and the Grand Canyon as America's best national park. Gen Z and pet ownership — why younger generations are spending big on pet care and treating pets as primary emotional relationships. Costco gas stations hit record demand as national gas prices surge past $4 a gallon. Hollywood popcorn buckets become the hottest collectible in pop culture marketing — The Devil Wears Prada 2 and Christopher Nolan's The Odyssey buckets are selling out and reselling for $250 on eBay. Taylor Swift drops a new song for Toy Story 5 — and breaks Apple Music and Spotify records within 24 hours. Caitlin Clark faces an unfair double standard as media scrutinizes her competitive sideline behavior — the same behavior celebrated in Michael Jordan and Kobe Bryant. Zebra striping — the new drinking trend of alternating alcoholic and non-alcoholic beverages driving a 22% surge in NA beverage sales. Victoria's Secret stock surges 44% as CEO Hillary Super leads a brand comeback by leaning back into the brand's identity. And the sleep divorce trend — why 1 in 3 Americans are sleeping in separate beds and what it means for the mattress industry. On Brand with Donny Deutsch drops new interviews every Thursday and Brands of the Week every week. Subscribe, rate, and review on Apple Podcasts, Spotify, and wherever you listen to podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices

Should applicants use AI in their admissions essays? With extreme caution, as we hear this week.

In this episode of The Private Equity Podcast, Alex Rawlings speaks with David Bell, former Wharton Professor of Marketing and early-stage investor in consumer companies including Diapers.com, Warby Parker, Harry's and Jet.com. David shares what he looks for in standout consumer brands, why founder insight and capital discipline matter, and how businesses can build emotional and symbolic value around everyday products.David explains why great consumer companies often begin with a simple frustration: what is wrong with the status quo? From buying diapers online to rethinking eyewear pricing, the best founders identify a clear customer problem, build a strong proposition, and execute with precision. He also discusses why overcapitalisation can damage consumer brands, using Allbirds and Casper as examples of businesses that grew quickly but struggled to sustain value.The conversation explores omnichannel distribution, brand storytelling, cultural relevance and genuine product innovation. David highlights Touchland, Warby Parker, Native, EOS, Hello and Happy, showing how founders can elevate mundane categories through design, positioning and customer experience.Key Takeaways: Great consumer investments often start with a visceral customer problem.  Capital efficiency is critical because consumer exits rarely match software-scale outcomes.  Strong brands combine functional, emotional and symbolic value.  D2C alone is rarely enough; winning brands need a measured omnichannel strategy.  The next wave of consumer winners needs real product innovation, not just better go-to-market.  Founder obsession with small details in design, scent, usability and narrative creates differentiation. Timestamps: 00:03 – Introduction to David Bell and his journey from New Zealand to New York 01:00 – David's background at Wharton and investing in consumer companies 01:28 – What attracted David to early winners like Diapers.com 02:19 – Why Diapers.com solved a fundamental customer pain point 03:15 – The importance of insight, execution and market size 03:44 – Lessons from Allbirds and the dangers of overcapitalisation 05:32 – How great consumer brands scale beyond the early stage 06:27 – The shift from pure D2C to omnichannel distribution 07:52 – Why strategic buyers value brands with retail traction 09:18 – Why some consumer brands fail to sustain momentum 10:11 – Touchland and the reinvention of hand sanitiser 11:33 – Cultural relevance, collaborations and emotional connection 12:03 – Sponsor message from Grata 12:32 – What makes a brand fundamentally strong 13:29 – Diapers.com and the power of descriptive branding 14:26 – Warby Parker's storytelling, fairness and American heritage 15:49 – Building cognitive associations through brand activations 17:40 – How much brand success is intentional versus luck 18:09 – Opportunities in legacy consumer categories 19:24 – Why obsessive attention to detail matters 20:19 – Craig Dubitsky, EOS, Hello and elevating mundane products 21:15 – Happy Coffee and design-led differentiation 22:14 – Where the consumer industry is today 22:43 – Capital-efficient growth and the Native deodorant example 23:39 – Why real product innovation now matters more than ever 24:36 – What David reads, watches and listens to 25:04 – Identifying white spaces in health, wellness and longevity 26:30 – Consumer opportunities through cultural arbitrage 27:27 – Lessons from Coca-Cola's global distribution and brand power 28:24 – How to connect with David Bell 28:52 – Closing remarksRaw Selection partners with Private Equity firms and their portfolio companies to secure exceptional executive talent. We focus on de-risking executive recruitment through meticulous search and selection processes, ensuring top-tier performance and long-term success.

Want help with your MBA applications? Book an MBAApplication Strategy Call. If you're new here, my name is Jahlen Brown. I'm a HarvardBusiness School student and former private equity analyst. I spent four years working in the industry, closed over $1 billion in transactions, and worked 80-hour weeks while building my MBA applications. Today, I create content to help ambitious professionals break into elite careers, earn admission to topbusiness schools, and create opportunities they never thought possible. How I got here... 20: Committed to breaking into private equity and became the first person in my family to work in finance21 yrs old: Finally broke into private equity and started myfirst internship at a real estate fund. Became involved with Sponsors for Educational Opportunity (SEO), helping underrepresented students break into competitive careers22 yrs old: Graduated Rutgers University Summa Cum Laude and landed three private equity job offers. Began my career in acquisitions in NYC 23 yrs old: Became the protégé of Joe Plumeri II, former CEOof Citibank, Willis Group, and Primerica24 yrs old: Private equity fund consolidated and learned Iwas getting shoved out. Experienced my first major setback and began searching for new opportunities25 yrs old: Started a new private equity role, signed myfirst M&A deal, and decided I wanted to create even bigger opportunities for myself. I began preparing for business school while working 80-hour weeks26 ys old: Accepted into 11 business schools, includingHarvard, Wharton, Columbia, Booth, and Dartmouth26 ys old: Earned approximately $910,000 in scholarships,including full-tuition scholarships to Cornell and Yale26 ys old: Became the first person in my family to attend anIvy League institution26 ys old: Achieved all of this despite having a low GMATscore while working 80-hour weeks Today: I'm attending Harvard Business School and documenting everything I learn about admissions, recruiting, entrepreneurship, investing, and career growth. I grew up in a lower-class family, attended communitycollege, transferred to Rutgers, worked my way into private equity, and eventually earned admission to the best business schools in the world. I was never the smartest applicant I just refused to quit after I got knocked down If you stick to your goals, you can do far more than youthink To everyone chasing a bigger future: Keep betting on yourself Keep moving Never quit JahlenFollow Jahlen's other platforms: YouTube | LinkedIn

Alan's Soap https://AlansSoaps.com/ToddHonor John's memory and the legacy he created for Ian and Alan with Alan's Artisan Soaps “John's Favorites” bundle.  Get one bar of each of his favorites for only $28.99. Bulwark Capital https://KnowYourRiskPodcast.comBe confident in your portfolio with Bulwark! Schedule your free Know Your Risk Portfolio review. Go to KnowYourRiskPodcast.com today. Renue Healthcare https://Renue.Healthcare/ToddYour journey to a better life starts at Renue Healthcare. Visit https://Renue.Healthcare/Todd Bonefrog https://BonefrogCoffee.com/ToddGet the new limited release, The Sisterhood, created to honor the extraordinary women behind the heroes. Use code TODD at checkout to receive 10% off your first purchase and 15% on subscriptions.LISTEN and SUBSCRIBE at:The Todd Herman Show - Podcast - Apple PodcastsThe Todd Herman Show | Podcast on SpotifyWATCH and SUBSCRIBE at: Todd Herman - The Todd Herman Show - YouTubeA paper from the Wharton school of business says unless a specific tax is installed, AI will destroy the country. Zach Abraham of Bulwark Capital Management joins to help us break it down.Episode Links:Plans released for a $16 billion mile-long ship capable of carrying 80,000 people. The 'Freedom Ship' would be home to about 50,000 people, with space for 10,000 tourists and 20,000 crew members.

Most executives never run the math on what it really costs to stay in a career that no longer fits. They calculate what leaving would cost them, the income, the title, the security they've spent fifteen or twenty years building, but they almost never run the numbers on what staying is already taking from them.   In Part 3 of our Executive Career Change series, you'll see what the math actually looks like, including the four real costs of staying that compound year after year, the data on what really happens to income after a structured executive career change, and the three questions that surface the truth for almost every executive we've worked with.   The salary you've been protecting becomes something you've been paying for. And once you see what staying actually costs you, the math of leaving looks completely different.   What you'll learn: The four real costs of staying in a career that no longer fits, including the identity loss that almost no executive sees coming until it's too late What the Wharton data actually shows about income recovery after an executive career change, and why "leaving will cost you forever" is almost always wrong Why the income math of staying isn't safe, it's a slow leak most people never count The three questions our team uses to surface what's actually going on for executives stuck in the trap Why the first real move isn't the resignation or the announcement, it's something simpler and more important   Our book, Happen To Your Career: An Unconventional Approach To Career Change and Meaningful Work, is now available on audiobook! Visit  happentoyourcareer.com/audible to order it now! Visit happentoyourcareer.com/book for more information or buy the print or ebook here! Want to chat with our team about your unique situation? Schedule a conversation   Free Resources What career fits you? Join our free 8 Day Mini Course to figure it out! Career Change Guide - Learn how high-performers discover their ideal career and find meaningful, well-paid work without starting over.   Related Episodes Stuck in a Career You're Unhappy With? Fear Of Taking Risks Could Be Keeping You There (Spotify / Apple Podcasts) Should I Quit My Job? How to Know It's Time (Spotify / Apple Podcasts)   Mentioned Episodes: Executive Career Change Series Part 1 of 3 (Spotify / Apple Podcasts) Executive Career Change Series Part 2 of 3 (Spotify / Apple Podcasts) Katie's Career Transition Story (Spotify / Apple Podcasts)

On this episode of Proof-of-PR, Kelley Weaver is joined by Eve Smith Davies. She decodes complex tech and builds magnetic brands. As co-founder and Brand Director of UME—a design studio for frontier innovation—she's spent 20 years working at the intersection of technology, sustainability, and systems change across countries, sectors, and challenges. Her specialty is taking complex innovations and making them impossible to ignore. She's partnered with tech leaders and rising stars alike—from Aztec and Mina to NIKE, Hilton, Ocean Conservancy, and Whole Foods Market—to clarify their vision, position their value, and scale their impact across climate tech, tough tech, web3, and AI. A former branding and marketing instructor at Parsons and guest speaker at Columbia and Wharton business schools, she brings strategic rigor, fresh curiosity, and a systems lens to every challenge. Her work has been recognized in Forbes and It's Nice That. To stay up-to-date on upcoming guests and news by following us on Twitter at @ProofOfPR. #PRtips #TheBitcoinConference #ProofofPR #MediaRelations ●▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬● ⏰ Timestamps: 0:00 | Intro 1:25 | Who is Eve Smith Davies? 4:00 | How to build a compelling brand 8:48 | Mina story 14:11 | What metrics to measure in Web3 17:23 | How is Web3 brand building different from traditional companies? 21:23 | Research is important in brand building 25:18 | BITWIRE AD 26:33 | When Crypto marketing goes wrong 29:04 | Impact of AI on brands 32:42 | Importance of organization structure 36:35 | Power of brand & thought leadership for Founders 37:56 | Advice to Founders building a brand from scratch 42:30 | Get in touch with Eve & UME 43:13 | Outro ●▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬●

Welcome to Digital Learning Today. In this episode, Jeff Bradbury explores the strategic systems that shape the future of education, focusing on Instructional Coaching, Artificial Intelligence, Professional Learning, and the latest Educational Technology Trends. In this episode, Lydia Hall from Adobe introduces Aqua, a free creative app for kids that fosters artistic expression and innovation. We explore how Aqua supports student creativity, privacy, and future skills, along with insights on integrating AI and tech tools in education. Become a High-Impact Leader: This episode is just the beginning. To get the complete blueprint for designing and implementing high-impact systems in your district, get your copy of my book, "Impact Standards." Strategic Vision for Digital Learning:Learn how to create a district-wide vision that aligns digital learning with your educational goals, transforming how standards-based instruction is designed and supported.Curriculum Design and Implementation:Discover practical strategies for integrating digital learning into existing curricula, creating vertical alignment of skills, and mapping digital learning across grade levels.Effective Instructional Coaching:Master the art of coaching people rather than technology, building relationships that drive success, and measuring impact through student engagement rather than just technology usage. Purchase your copy of “Impact Standards” on Amazon today! Chapters: 00:00 Introduction to Aqua by Adobe03:45 The Creative Playground for Kids05:47 The Development Journey of Aqua08:46 Empowering Young Entrepreneurs11:54 Integrating AI in Education14:54 Future of Aqua and Educational Technology Resources Mentioned in This Episode: Aqua by Adobe -https://aqua.adobe.comAdobe Creative Cloud -https://www.adobe.com/creativecloud.html About our Guest: Lydia Hall Lydia Hall is Venture Lead and Co-Founder of Project Aqua at Adobe, where she co-leads the company's first-ever product for kids and families. Built within Adobe's incubator program, Project Aqua was inspired by Lydia's experience as a parent. The app extends Adobe's creative ecosystem to young creators through art, design, and play in a safe, educational mobile environment. A serial founder and growth strategist, Lydia has held executive roles across four venture-backed startups. She founded her first company, an edtech platform, while attending Penn Law and Wharton; and later served as COO at Chalkup, a content collaboration platform acquired by Microsoft. Lydia participated in Y Combinator Imagine K12, and was recognized by the Forbes 30 Under 30. Outside of work, Lydia is a lifelong sailor and U.S. Sailing Association–certified coach. Competitive racing has shaped her approach to leadership — balancing focus and adaptability amid shifting winds, changing tides, and the occasional sea monster. Links of Interest LinkedIn -https://www.linkedin.com/in/lydiahallTwitter -https://twitter.com/lydiahall Let's Work Together Contact Me Today:https://www.teachercast.net/contact Follow on Social Media LinkedIn:https://www.teachercast.net/linkedinTwitter/X:https://www.teachercast.net/twitterBlueSky:https://bsky.app/profile/jeffreybradbury.bsky.socialYouTube:http://teachercast.net/youtube Subscribe to This Podcast Apple Podcasts:https://podcasts.apple.com/us/podcast/digital-learning-today/id546631310Spotify:https://open.spotify.com/show/0n6S0WcyzQ1rpKWJ8iZPLJ?si=a1227a7c5e0b48e4 Check Out Additional TeacherCast Programming Digital Learning Today:https://podcasts.apple.com/us/podcast/digital-learning-today/id546631310Ask the Tech Coach:https://podcasts.apple.com/us/podcast/ask-the-tech-coach/id1067586243The Jeff Bradbury Showhttps://podcasts.apple.com/us/podcast/the-jeff-bradbury-show/id519685828 Book Jeff for your Next Event Jeff Bradbury (ISTE “20 to Watch” Award Winner and ISTE Certified Educator) is available for keynote speaking, workshop facilitation, and live event broadcasting. With expertise in educational technology and professional development, Jeff brings engaging content and practical strategies to conferences and professional learning events. Visit Jeff's Website:https://jeffreybradbury.comContact Jeff Directly:https://jeffreybradbury.com/contact/ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ [gravityform id="2" title="true"]

Key Topics Covered: 1. Defining True Wealth Wealth is about creating predictable income and financial security. The goal is freedom, experiences, and a low-stress lifestyle. 2. From Corporate Career to Property Entrepreneur Transitioning from employment to financial independence through property. Recognising when a traditional career path no longer aligns with personal goals. 3. The Impact of Rich Dad Poor Dad How financial education can change perspectives on wealth building. The importance of developing an investor mindset. 4. Learning Through Failure Early mistakes in serviced accommodation created valuable lessons. Setbacks can become turning points for future success. 5. The Demand-Led Investment Approach Find the demand before choosing the property. Reverse-engineering investments around proven market needs. 6. Understanding Serviced Accommodation The opportunities and risks of short-term rental strategies. Why demand is critical for long-term profitability. 7. Building Multiple Income Streams Combining trading, investment, and coaching businesses. Creating diversified sources of recurring income. 8. Wealth, Family, and Lifestyle Using wealth as a tool to create time, experiences, and flexibility. Balancing financial success with family, health, and personal fulfilment. Actionable Takeaways Focus on building assets that generate predictable, recurring income rather than chasing quick wins. Identify genuine market demand before investing in a property or launching a new venture. Treat mistakes as learning opportunities and use them to improve future decision-making. Invest in your financial education to develop a stronger wealth-building mindset. Build multiple income streams to reduce risk and increase financial resilience. Align your wealth-building activities with your personal values, family goals, and desired lifestyle. Review your current investments and ask whether they are driven by demand or by assumptions. Prioritise long-term consistency over short-term excitement when creating wealth. Resources & Next Steps WealthBuilders Membership: Free access to guides, webinars, and community Download our FREE Pensions and Inheritance Tax Guide Devenir Plus - Become more in every area of your life Connect with Us: Listen on Spotify, Apple Podcasts, YouTube, and all major platforms. Next Steps On Your WealthBuilding Journey:   Join the WealthBuilders Facebook Community Schedule a 1:1 call with one of our team Become a member of WealthBuilders If you have been enjoying listening to WealthTalk - Please Leave Us A Review!

El P. Mark Wharton crece en una familia protestante en Reino Unido. Durante su infancia crece así hasta que llega a la universidad y comienza a sentirse como un pez en una gran pecera; las preguntas existenciales comienzan a aparecer en su mente y su corazón y un buen día le invitan a ir a Misa. Desde ese momento, dichas preguntas cobrarán más profundidad y será en la Iglesia Católica donde vaya encontrando respuesta. Finalmente, decidirá, tras un encuentro con las reliquias de santa Teresita y con la Eucaristía, hacerse católico. A partir de ahí, el Señor comenzará a entrar en su vida y a pedirle todo. Descubre cómo el P. Mark llega a ser católico y cómo el Señor le pide que sea sacerdote de su Corazón en este nuevo «Cambio de Agujas».

As we enter summer, we talk about how applicants can strategically approach those early MBA application dates. Plus, we demystify the ‘career vision'. 

In this episode of The Yegi Project, Barbie Wharton shares her journey from experiencing Bell's palsy to becoming a motivational coach and podcast host. She discusses the importance of using your voice, handling life's seasons, and building authentic connections to live a fulfilled life.Connect with Barbie!Instagram: https://www.instagram.com/realtalkbarbie/Website: https://www.barbiewharton.com/ Takeaways* Using your voice for personal growth* Handling life's seasons and challenges* Building authentic relationships and communityIf you would like to be a guest on a future episode of The Yegi Project, please email info@yegiproject.comThe Yegi Project is available on Apple Podcasts, Spotify, Stitcher and more!https://linktr.ee/theyegiprojectDisclaimer: This podcast or any other The Yegi Project episodes on this platform or other podcast streaming platforms is not legal business or tax advice. I make this content based on my own experience as a business owner and MBA for educational and entertainment purposes only. #theyegiproject Podcast Audio & Video Edited by Elizabeth HadjinianInstagram - https://www.instagram.com/theyegiprojectTikTok - https://www.tiktok.com/@theyegiproject YouTube - https://www.youtube.com/@theyegiproject

We'll be back soon with new episodes. In the meantime, enjoy this episode about Jho Low, the fraudster who charmed Hollywood's elite while allegedly stealing over $4 billion from one of Malaysia's sovereign wealth funds.Jho Low, a Malaysian-born businessman, will do anything to climb the social ladder. After attending Wharton business school, he establishes himself as a globe-trotting playboy with a celebrity entourage. He uses his money to get near Leonardo DiCaprio, Miranda Kerr, Paris Hilton, Britney Spears, and Kim Kardashian. But the source of Jho Low's seemingly endless cash is a mystery…. Until one of his former associates decides to blow the whistle.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What makes a podcast feel authentic?In this episode, we sit down with Jennifer Moss, Co-Founder and Chief Creative Officer of JAR Podcast Solutions, one of the world's leading branded podcast agencies. Jennifer has helped organizations ranging from Amazon and Cirque du Soleil to Wharton create podcasts that do more than promote a brand—they tell stories that audiences genuinely want to hear.The conversation explores why so many brand podcasts fail to connect, what separates great storytelling from corporate messaging, and how brands can create audio content that builds trust, engagement, and long-term audience relationships.Jennifer also shares her perspective on the growing role of AI in content creation, why human-centered storytelling matters more than ever, and what she has learned leading creative teams at the forefront of the podcast industry.The PR Podcast is a show about how the news gets made. We talk with great PR people, reporters, and communicators about how the news gets made and strategies for publicity that drive business goals. Host ⁠⁠Jody Fisher⁠⁠ is the founder of Jody Fisher PR and works with clients across the healthcare, higher education, financial services, real estate, entertainment, and non-profit verticals. JAR Podcast Solutionswebsite: https://jarpodcastsolutions.comThe PR Podcast Facebook: https://www.facebook.com/ThePRPodcast/Twitter: https://x.com/ThePRPodcast1Instagram: https://www.instagram.com/theprpodcast_/TikTok: https://www.tiktok.com/@theprpodcast?

Most clinic owners lose 40 to 60% of their patients in the first 8 weeks. The enthusiasm fades, the patient self-discharges, and the practice quietly bleeds revenue it already paid to acquire.Dr. Jay Greenstein knows the math better than almost anyone. In 2003, his practices were growing fast and he was still going broke, because he understood clinical care but not systems, process, or collections. That crisis sent him to Wharton's small business program, into Jack Welch's playbook and Six Sigma, and eventually to building EMBODI: a platform that uses behavioral science, gamification, and AI to turn patient follow-through into measurable outcomes and practice income.In this episode, Jeff pushes Jay past the pitch and into the operational reality. You get the data, the billing mechanics, the hiring lessons, and the version that failed before any of it worked.What You'll Learn:- The exact retention numbers from 7 independent practices and over 4,000 patients (40.48% more visits, 36.12% more revenue for EMBODI users versus non-users)- How EMBODI qualifies as software as a medical device and opens 6 Remote Therapeutic Monitoring billing codes most owners are leaving on the table- Why rising patient acquisition costs make lifetime value the only number that matters, and how to engineer it- The "first who, then what" hiring philosophy Jay learned the hard way, and the resume-first mistake that cost him for years- What Jay would do to rebuild from zero in 30 days using today's AI toolsIf you got value from today's show, you know the only fee we ask: hit share and send this to one clinic owner who needs it.Want to talk through your own growth bottleneck? Book a call: https://api.leadconnectorhq.com/widget/bookings/discoveryroadmapcallpodcastyoutubeLearn more about EMBODI: https://embodihealth.com/Connect with Dr. Jay Greenstein: https://www.instagram.com/drjaygreenstein/Earnings disclaimer: Results discussed reflect the experiences of the guest and the specific practices studied. Individual results vary and are not guaranteed. Nothing in this episode is financial, legal, or medical advice.

What if luck is not random, but designed? In this episode of Leveraging Thought Leadership, Peter Winick sits down with Judd Kessler, Wharton professor and author of "Lucky by Design: The Hidden Economics You Need to Get More of What You Want." Judd's work brings market design out of the academic journal and into daily life. He studies the hidden systems that determine who gets access, who gets opportunity, and who gets left waiting. These systems are everywhere. School programs. Job assignments. Consulting projects. Ticketing platforms. Government services. Nonprofit resources. Even your own time and attention. Judd's thought leadership gives leaders a new lens. First, see the market. Then understand the rules. Then decide whether those rules are helping or hurting the outcomes you want. For organizations, this is not theoretical. Poorly designed internal markets create frustration, waste, and inequity. Better rules can improve allocation, retention, performance, and trust. Peter and Judd explore how a book can move academic insight into practical use. They also dig into the harder work after publication: building an audience, entering the cultural conversation, and turning expertise into influence. This conversation is a sharp look at how thought leadership scales when it makes invisible systems visible. And when it gives people the tools to redesign them. Three Key Takeaways: • See the hidden market. Many opportunities are shaped by invisible systems, from school programs and job assignments to access, attention, and scarce resources. • Design better rules. Poorly built systems create frustration, waste, and unfairness. Better rules lead to smarter outcomes. • Make ideas practical. Strong thought leadership turns complex concepts into tools people and organizations can actually use. If this conversation made you think differently about the hidden rules that shape behavior, go back and listen to our episode with Luke Battye. Both episodes explore how people make decisions inside systems they often do not see. Judd Kessler looks at hidden markets, scarcity, and the rules that determine who gets what. Luke Battye looks at behavior change, design thinking, and how small shifts in context can change what people do next. Together, these episodes give you a sharper lens for understanding systems, incentives, and behavior. You'll walk away with practical ways to design better outcomes for customers, teams, and organizations.

Ste is joined by Andy and Ian for our Liverpool Transfer Podcast to discuss the Reds targeting Adam Wharton from Crystal Palace and Yan Diomande from RB Leipzig, as well as the potential sale of Curtis Jones to Inter Milan.Get an exclusive 15% discount on Saily data plans! Use the code redmentv at checkout. Download the Saily app or go to: https://saily.com/redmentv ⛵ Hosted on Acast. See acast.com/privacy for more information.

I WAS THINKING:  The Difference Between Hobo and Homeless Cultures // Spotify CEO defends AI music, wants you to stop calling it 'slop'. David Solomon even played an AI-generated house track at Wharton. The No. 1 Song On U.S. iTunes—And Several Other Countries—Is AI Generated // “Star-Studded” Lineup Announced for Freedom 250 Celebration

I WAS THINKING:  The Difference Between Hobo and Homeless Cultures // Spotify CEO defends AI music, wants you to stop calling it 'slop'. David Solomon even played an AI-generated house track at Wharton. The No. 1 Song On U.S. iTunes—And Several Other Countries—Is AI Generated // “Star-Studded” Lineup Announced for Freedom 250 Celebration

A fire sale? An arms race? However you term it, business schools are slashing rates – we look at how applicants can score a scholarship.

Hilary Dubin is co-CEO and head of Jones' digital product & behavioral support program. She graduated from the University of Pennsylvania magna cum laude, majoring in cognitive science with a concentration in computation and cognition, an honors thesis on the effects of gender, realism, and role of virtual agents, and a minor from Wharton in consumer psychology.  She worked in David Brainard's visual neuroscience lab for 3 years and published 4 papers and supplementary materials on illumination discrimination (color perception). After Penn, she was selected as one of ten Americans to be a Ventures Fellow in the Excel Ventures incubator program in Tel Aviv, and continued on to be the inaugural member, and later program lead, of the US Associate Product Manager Program at Atlassian.  She worked as a product manager at Atlassian for 5 years, ultimately as Head of Confluence Editions & Admin Experience where she launched Confluence Premium & Free into multi-million dollar product offerings with 2M+ users. She hired & managed two PMs and lead a team of over 30 developers.  Prior to founding Jones, she and Caroline founded Cozier together, a sleep & loungewear brand designing ethical, effortlessly chic garments for every/body. Hilary started vaping casually in 2017 when the JUUL seemed relatively harmless and fun.  When the world went on lockdown in 2020, her casual vaping habit became a daily crutch for coping with stress and working from home. After over a year of unsuccessful cold-turkey quit attempts, she finally kicked her vaping habit in 2022 when Caroline suggested she try NRT.  Outside of work, Hilary loves hiking, backcountry skiing, trying to find the best burger in NYC, and playing with other people's dogs. In This Conversation We Discuss: [00:00] Intro [02:34] Creating products from personal pain points [06:52] Sponsor: Klaviyo  [08:59] Meeting potential customers where they are [10:47] Adapting products based on user feedback [13:48] Testing market demand with waitlists [16:02] Sponsor: Electric Eye [17:10] Maximizing personal networks for growth [18:34] Gathering behavioral data in early days [19:52] Callouts [20:02] Launching a product to engaged audiences  [22:09] Sponsor: Intelligems [24:09] Pivoting marketing to bridge early limitations [26:24] Driving organic traffic with relatable content  [30:33] Adding modern value to traditional products Resources: Subscribe to Honest Ecommerce on Youtube Nicotime mints and social app to quit vaping quitwithjones.com/ Follow Hilary Dubin linkedin.com/in/hilary-dubin-374156b4/ Follow Caroline Vasquez Huber linkedin.com/in/caroline-vasquez-huber Book a demo today at intelligems.io/ Schedule an intro call with one of our experts electriceye.io/connect Get your free demo klaviyo.com/honest If you're enjoying the show, we'd love it if you left Honest Ecommerce a review on Apple Podcasts. It makes a huge impact on the success of the podcast, and we love reading every one of your reviews!

Hour 2 of the show starts with us recapping how our favorite drivers performed in the Coke 600. We then talk about the upcoming OTA's for the Panthers and who they could use to replace Turk Wharton. We end the hour by reviewing the NBA playoffs from the weekend.See omnystudio.com/listener for privacy information.

This podcast was taped at a conference where I hosted several Penn Professors on a variety of topics. The audience included my friends who will join me in asking questions.Our speaker is Phil Tetlock who is a Professor at Wharton and the author of a book entitled Superforecasting. Often, we get our news and analysis from experts who make predictions that are terribly wrong. Phil has analyzed methods of forecasting and has found individuals and groups who are fantastic predictors of politics, war, and sports.I want to learn how AI and superforecasters working together will revolutionize the prediction process and why that is helpful to markets and mankind. Get full access to What Happens Next in 6 Minutes with Larry Bernstein at www.whathappensnextin6minutes.com/subscribe

To speak with an advisor and build a smarter college admissions strategy, book a Complimentary Strategy Call at:

Adam Wharton scored his first goal for Crystal Palace at Brentford, much to the delight of his Mum who danced to the tune of the Selhurst sound in the away end. Terence, Albert and Hesketh look back at the 2-2 draw in West London, look ahead to Arsenal's visit to South London and cover 'Spygate', Mother doing very Well and whether or not the latest managerial shuffle points Iraola towards the Palace dugout. Hosted on Acast. See acast.com/privacy for more information.

Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.

Charlotte Observer's Carolina Panthers beat reporters Mike Kaye and Alex Zietlow offer thoughts on what the Turk Wharton injury means for the team (0:50) and whether a free agent option makes sense (9:05) Then, they go over some of the favorite match-ups (11:10) and least favorite match-ups (15:10) from last week's schedule release before outlining the OTA battles to watch (18:10). Learn more about your ad choices. Visit megaphone.fm/adchoices

Should we think of AI as a co-intelligence and digital coworker rather than just a chatbot? Ethan Mollick, a professor at Wharton and author of numerous books including the New York Times bestseller “Co-Intelligence: Living and Working with AI,” says so. He joins WITHpod to discuss the practical application, adoption, and transformative impact of AI on work. Sign up for MS NOW Premium on Apple Podcasts to listen to this show and other MS podcasts without ads. You'll also get exclusive bonus content from this and other shows. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The day before Mother's Day, we're looking at the mixed emotions many moms feel: love, gratitude… and exhaustion. Dr. Corinne Low, a Wharton professor and author of Having It All, explains what the data shows about the pressures of modern motherhood — from how much time parents spend with kids today compared to decades ago, to the invisible work many moms still carry. Plus, how families can think differently about outsourcing help, and how even overwhelmed moms can make sure joy is still on the to-do list.   Learn more about our guest(s): https://www.theNewsWorthy.com/shownotes Join us again for our 10-minute daily news roundups every Mon-Fri!  Become an INSIDER and get ad-free episodes here: https://www.theNewsWorthy.com/insider Get The NewsWorthy MERCH here: https://www.theNewsWorthy.com/merch Sponsors: Get 20% off your DeleteMe plan when you go to JoinDeleteMe.com/newsworthy and use promo code NEWSWORTHY at checkout! Refresh your everyday with luxury you'll actually use. Head to Quince.com/newsworthy for free shipping on your order and 365-day returns! To advertise on our podcast, please email: ad-sales@libsyn.com

In this clip from Transfer Insight, Dan is joined by Liverpool Journalist David Lynch to discuss links to Crystal Palace's Adam Wharton and the likelihood of The Reds signing him this summer. Hosted on Acast. See acast.com/privacy for more information.

AI – and coverage of it – is everywhere. But what is artificial intelligence, really, beyond the buzzword? Each week, in a special new miniseries - ‘The AI End Game' - Chris Hayes is joined by preeminent experts on AI and its effects to help make sense of this revolutionary time in history. The series will feature in-depth conversations with experts, including: The Atlantic journalist Derek Thompson; professor at Wharton and New York Times bestselling author Ethan Mollick, professor of psychology at UC Berkeley and member of the Berkeley AI Research Group Alison Gopnik; former co-lead of the Ethical Artificial Intelligence Team at Google and co-founder of Black in AI Timnit Gebru; philosopher and cognitive scientist David Chalmers; author, host of the “Better Offline” podcast and writer of the “Where's Your Ed At” newsletter, Ed Zitron; The New York Times journalist and author, Michael Pollan, and more. The first episode is available now wherever you get your podcasts.  Want more of Rachel? Check out the "Rachel Maddow Presents" feed to listen to all of her chart-topping original podcasts.To listen to all of your favorite MS podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

AI – and coverage of it – is everywhere. But what is artificial intelligence, really, beyond the buzzword? Each week, in a special new miniseries - ‘The AI End Game' - Chris Hayes is joined by preeminent experts on AI and its effects to help make sense of this revolutionary time in history. The series will feature in-depth conversations with experts, including: The Atlantic journalist Derek Thompson; professor at Wharton and New York Times bestselling author Ethan Mollick, professor of psychology at UC Berkeley and member of the Berkeley AI Research Group Alison Gopnik; former co-lead of the Ethical Artificial Intelligence Team at Google and co-founder of Black in AI Timnit Gebru; philosopher and cognitive scientist David Chalmers; author, host of the “Better Offline” podcast and writer of the “Where's Your Ed At” newsletter, Ed Zitron; The New York Times journalist and author, Michael Pollan, and more. The first episode is available now wherever you get your podcasts.  Sign up for MS NOW Premium on Apple Podcasts to listen to this show and other MS podcasts without ads. You'll also get exclusive bonus content from this and other shows. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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We're excited to announce a new special WITHpod series, "The AI End Game: Power, Profit, and Progress." AI – and coverage of it – is everywhere. But what is artificial intelligence, really, beyond the buzzword? Each week, we'll be joined by preeminent experts on AI and its effects to help make sense of this revolutionary time in history. The series will feature in-depth conversations with experts, including: The Atlantic journalist Derek Thompson; professor at Wharton and New York Times bestselling author Ethan Mollick, professor of psychology at UC Berkeley and member of the Berkeley AI Research Group Alison Gopnik; former co-lead of the Ethical Artificial Intelligence Team at Google and co-founder of Black in AI Timnit Gebru; philosopher and cognitive scientist David Chalmers; author, host of the “Better Offline” podcast and writer of the “Where's Your Ed At” newsletter, Ed Zitron; The New York Times journalist and author, Michael Pollan, and more.    Sign up for MS NOW Premium on Apple Podcasts to listen to this show and other MS podcasts without ads. You'll also get exclusive bonus content from this and other shows. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We're excited to announce a new special WITHpod series, "The AI End Game: Power, Profit, and Progress." AI – and coverage of it – is everywhere. But what is artificial intelligence, really, beyond the buzzword? Each week, we'll be joined by preeminent experts on AI and its effects to help make sense of this revolutionary time in history. The series will feature in-depth conversations with experts, including: The Atlantic journalist Derek Thompson; professor at Wharton and New York Times bestselling author Ethan Mollick, professor of psychology at UC Berkeley and member of the Berkeley AI Research Group Alison Gopnik; former co-lead of the Ethical Artificial Intelligence Team at Google and co-founder of Black in AI Timnit Gebru; philosopher and cognitive scientist David Chalmers; author, host of the “Better Offline” podcast and writer of the “Where's Your Ed At” newsletter, Ed Zitron; The New York Times journalist and author, Michael Pollan, and more.  Want more of Chris? Download and follow his podcast, “Why Is This Happening? The Chris Hayes podcast” wherever you get your podcasts.To listen to this show and other MS podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.