Podcasts about X-ray crystallography

Viral vectors are a cornerstone of gene therapy and many employ experts in the viral vector services space to help design and produce their specialty vectors. These service providers are experts at making sure you get the vector you want with a titer and purity you need for your application. We're joined in this episode by Dr. Cliff Froelich, Head of Analytical Development for a viral vector services provider. Cliff and his team work with AAV, lentivirus, and other vectors to support multiple, and simultaneous, client projects. Specifically, we dive into how they use various analytical and molecular methods to monitor and assess identity, strength, purity, impurities, potency, efficiency, empty/full ratios, safety, and more. As you might expect, it's not a one-method-does-it-all approach or solution. Yes, digital PCR is in the mix here, and Cliff does a great job of outlining where it shines relative to the other methods they use regularly in their GMP practice. In our career corner portion, you'll hear about Cliff's circuitous career path, which includes stints in the poultry industry and time as a clinical dietitian. Through it all, and into his current role, Cliff brings a passion and genuine interest for the science and its potential to affect lives. Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

On this ID the Future, philosopher of biology Paul Nelson further explores AlphaFold 2, a cutting edge computer program from Google's DeepMind designed to rapidly suss out important secrets in the realm of proteins, indispensable molecular biological workhorses that come in thousands of different shapes and sizes. Nelson enthuses about AlphaFold 2 but also explains why he is convinced that AlphaFold's creators have hit a series of immovable obstacles. The watchword here—orphans. Tune in to learn what these mischievous orphan proteins are about, and what they suggest for AlphaFold, evolution, and intelligent design. Source

On today's ID the Future, Lehigh University biologist Michael Behe argues that Darwinism was built on a foundation of ignorance. Through no fault of Darwin's, neither he nor anyone else in his day had a clue about the nature of cellular life and biological information, says Behe. Even the biologists of the Neo-Darwinian synthesis in the first half of the twentieth century were fairly clueless about the foundation of life, Behe says. When researchers did finally begin to unravel the sophisticated foundations of life, earlier notions of how evolutionary processes might have invented the great diversity of life forms on earth were exposed as causally inadequate. Behe says that in fact all the attempts to rescue the idea of mindless Read More › Source

This week we're celebrating the hundredth birthday of DNA pioneer Rosalind Franklin and how her work helped to unravel the DNA helix. Plus, in the news: COVID causes heart damage, water shortages in England thanks to climate change, and magic bullets to make shellfish more nutritious... Like this podcast? Please help us by supporting the Naked Scientists

The 2019 Haldane Lecture was delivered by Sir Venki Ramakrishnan, President of the Royal Society, on February 7th at Wolfson College, Oxford. The lecture was introduced by College President Sir Tim Hitchens. The thousands of genes in our DNA are translated by ribosomes - ancient, enormous molecular machines that read the genetic code to make the thousands of proteins that carry out the functions of life. Although the ribosome was discovered in the 1950s, unravelling its million atom structure took over four decades. Venki Ramakrishnan will frame this in term of his career and show how science does not proceed in a series of logical steps but in fits and starts, with many characters and their egos, rivalries, competition and collaboration, blunders and dead ends. Sir Venki is a structural biologist who in 2009 received the Nobel Prize in Chemistry and was knighted in 2012. In 2015, he was elected as President of the Royal Society.

Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. In the process of drug discovery, X-ray crystallography is the most sensitive way to find out which compounds bind to a target protein. Recent advances in technology allow researchers to test many more compounds, much more rapidly. The ultimate aim is to bring much needed new treatments to patients.

Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. In the process of drug discovery, X-ray crystallography is the most sensitive way to find out which compounds bind to a target protein. Recent advances in technology allow researchers to test many more compounds, much more rapidly. The ultimate aim is to bring much needed new treatments to patients.

Richard Neutze discusses a structural analysis of light-induced structural changes in the visual pigment rhodopsin.

Oxford Sparks presents an adventure in X-ray crystallography. Find out more and read about the science behind the animation at www.oxfordsparks.net/crystal.

Dr Richard Cooper on x-ray crystallography - an incredibly powerful technique for determining the 3D structure of crystals.

Diomedes Logothetis and Rahul Mahajan explain how G proteins activate a potassium channel to slow heart rate.

Andrew Cairns and Ines Collings, DPhil students in the Goodwin Group, explain how they make single crystals in the lab and study their unusual properties. By showing how to break the rules governing 'normal' materials, this research could lead to the design of brand new and useful substances in future.

Andrew Cairns and Ines Collings, DPhil students in the Goodwin Group, explain how they make single crystals in the lab and study their unusual properties. By showing how to break the rules governing 'normal' materials, this research could lead to the design of brand new and useful substances in future.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

Structural analysis reveals how a Wnt binds to its receptor.

Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Prof. Yvonne Jones is director of the Cancer Research UK Receptor Structure Research Group. Her research focuses on the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer.

Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Cells communicate through receptors on their surface; however, when these finely tuned systems don't work correctly, diseases can be triggered. Professor Yvonne Jones has been working to identify the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer. Professor Jones is director of the Cancer Research UK Receptor Structure Research Group.

Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Prof. Yvonne Jones is director of the Cancer Research UK Receptor Structure Research Group. Her research focuses on the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer.

Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Cells communicate through receptors on their surface; however, when these finely tuned systems don't work correctly, diseases can be triggered. Professor Yvonne Jones has been working to identify the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer. Professor Jones is director of the Cancer Research UK Receptor Structure Research Group.

Drug Discovery: On this week's Naked Scientists, drug development goes under the microscope as we explore two new ways to find the treatments of tomorrow. We find out why size is important when it comes to chemicals that can kill superbugs, and how soil bacteria hold the chemical clues to the next generation of antibiotics. Plus, how sheets of carbon can be used to reveal single atoms of hydrogen beneath the microscope, how scientists have homed in on the part of the brain linked to obsessive compulsive disorder, and why electronically tagging jellyfish can tell us a sea turtle's secrets.... Like this podcast? Please help us by supporting the Naked Scientists

Drug Discovery: On this week's Naked Scientists, drug development goes under the microscope as we explore two new ways to find the treatments of tomorrow. We find out why size is important when it comes to chemicals that can kill superbugs, and how soil bacteria hold the chemical clues to the next generation of antibiotics. Plus, how sheets of carbon can be used to reveal single atoms of hydrogen beneath the microscope, how scientists have homed in on the part of the brain linked to obsessive compulsive disorder, and why electronically tagging jellyfish can tell us a sea turtle's secrets.... Like this podcast? Please help us by supporting the Naked Scientists