Podcasts about Tyrosine

Chronic myeloid leukemia is a myeloproliferative neoplasm that affects approximately 5 million people worldwide. Tyrosine kinase inhibitors, such as imatinib, have substantially improved survival in patients with chronic myeloid leukemia. In this podcast, author Elias J. Jabbour, MD, of the University of Texas MD Anderson Cancer Center, discusses diagnosis and treatment of chronic myeloid leukemia with JAMA Deputy Editor Mary McDermott, MD. Related Content: Chronic Myeloid Leukemia

Amino acids are the true building blocks of the human body. This episode of Vitality Radio focuses specifically on Lysine, Tyrosine, and Acetyl-L-Carnitine. Jared unpacks the unique impact of these powerful aminos and why they deserve a closer look. You'll learn about their impressive benefits as individual nutrients - immunity, brain boosting, energy, thyroid health, and more! Jared also explains how single amino acids work vs. protein as a whole, and additionally, the role of digestive enzymes in breaking down protein to ensure we absorb these vital amino acids. Products:Lysine, Tyrosine, and Acetyl-L-Carnitine Additional Information:#479: Amino Acid Spotlight: Glycine, Citrulline, and Glutamine#412: A Natural Approach to Supporting Your Body Through ShinglesVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

In this episode, we explore the connections between Autism and Parkinson's, focusing particularly on the basal ganglia and its substructures, notably the substantia nigra within the midbrain. We discuss how the substantia nigra, known for its high concentration of neuromelanin, plays a critical role in these disorders. The episode examines how neuromelanin, a dark pigment, not only absorbs all frequencies of light but also has antioxidant properties, binds metals, and acts as a neuroprotector. This discussion leads into the broader implications of environmental signals, particularly light, on human biology, touching on how modern changes in light exposure might affect these conditions.We examine the role of tyrosine in the synthesis of neuromelanin and its derivatives like dopamine, which are crucial for neural function. We look at how deficiencies or imbalances in these pathways could lead to the symptoms observed in Autism and Parkinson's, including motor function issues. The conversation also covers the direct and indirect pathways in the basal ganglia, explaining how these pathways facilitate or inhibit movement, respectively, and how their dysfunction can manifest in the characteristic motor symptoms of both disorders. We also touch on the significance of thyroid function, particularly the roles of T3 and T4 hormones, in brain development and neuron health, tying these elements back to the overarching theme of energy loss and transduction in both Autism and Parkinson's.Autism and Parkinson's are a lack of, or a loss of, energy.Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB: https://youtu.be/2-IA_gunXbwTree comparison https://youtube.com/shorts/cLu53oVRRjI0:00 Autism and Parkinson's; Basal Ganglia; Substantia Nigra; Neuromelanin; Internal Calculators2:15 Tyrosine; Chromophores; Aromatic Amino Acids3:50 Biological Energy; Mitochondria; Environmental Signals; Cytochrome C Oxidase; Autism Research Miss6:20 Deep Brain Stimulation6:48 Neuromelanin9:02 Reverse Engineer ATPase10:48 Tree Examples11:45 Hypoxia and loss of energy & dopamine12:26 Eyes, hair, & skin; RPE; efficiency & power; What is Light?13:58 Light; Information & Energy; electromagnetic; wave-particle duality; sunlight versus artificial light17:08 Thyroid; T3 & T4; Iodine18:31 Roles of T323:00 Loss of energy in the womb & Autism research25:00 Melanin + Water = Electrons26:40 Basal Ganglia; "Motivations" & Movements; Direct Pathway30:55 Indirect Pathway32:52 Go, No-Go; Action selection, learning & habits; fine motor skills34:18 Parkinson's and loss of timing & energy; modulating the two pathways & dopamine37:07 Reviews/Ratings & contact infoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

In Episode 155 of the PricePlow Podcast, Ben, Mike, and a panel of beta-testers from the PricePlow Discord sit down with Dan Grasso from MuscleTech to dive into the evolution of the fan-favorite pre-workout, EuphoriQ. Known for its balanced energy and smooth focus, EuphoriQ quickly became a staple in the supplement community after its initial release with paraxanthine. Dan, who has been integral to the development of EuphoriQ V2, takes us through the journey from the original formula to this newly upgraded version, revealing the thought process and customer feedback that influenced each enhancement. Beta-Testing EuphoriQ V2: How Does the Small Yohimbe Dose Hit? Throughout the episode, the team explores how V2 preserves what made EuphoriQ popular while improving on pump, endurance, and mental clarity with adjusted doses of ingredients like L-citrulline, nitrates, and tyrosine. Dan highlights MuscleTech's approach to incorporating feedback and adapting the formula to align with evolving customer expectations, while maintaining the brand's commitment to effective, scientifically-backed products. In addition to product formulation, the discussion covers EuphoriQ V2's distribution strategy, flavor development, and MuscleTech's plans for broader accessibility. Tune in for an engaging conversation on the craft of refining a premium pre-workout, along with exclusive insights into MuscleTech's vision for the future of performance supplements. https://blog.priceplow.com/podcast/muscletech-euphoriq-v2-beta-test Video: The PricePlow Discord Beta-Tests EuphoriQ V2 https://www.youtube.com/watch?v=1n9xdRdlP_E Detailed Show Notes: Beta-Testing MuscleTech EuphoriQ V2 (00:00) – Introduction to EuphoriQ V2 (00:45) – The Evolution from V1 to V2 (06:15) – User Experiences and Feedback (10:45) – Focus and Performance Insights (18:00) – Comparative Analysis with Other Pre-Workouts (22:00) – Flavor Innovations and Preferences (26:00) – Exploring Unique Flavors: Watermelon and Yuzu Lemonade (30:15) – The Future of V2: Retail Strategies and Availability (33:30) – Enhancing Focus: The Role of Tyrosine and Paraxanthine (36:15) – Expectations vs. Reality: Feedback on V2 Samples (40:45) – Potential for New Nootropic Products (42:15) – The Science Behind Beta-Alanine and User Experiences You can read our main EuphoriQ V2 article, and find deals on PricePlow in the widgets below. As always, subscribe to the PricePlow Podcast on your platform of choice, and leave us a 9000-star review!

For today's episode, Nicole Rincon, PA-C, returns to discuss the risks associated with Autism development. The conversation spans from before conception through to after birth. We'll explore how factors related to the mother can influence autism risk, and we'll look at specific tests and signs in the body (labs and biomarkers) that have been linked to Autism. Additionally, we'll cover environmental influences, dietary considerations, acute medical conditions and medications, seasonal patterns, and various other aspects to be mindful of.By the end of the episode, we hope you'll gain valuable insights to consider as you navigate pregnancy. Our goal is to educate listeners, especially those who are pregnant or planning to conceive, about these potential risk factors, equipping them with the knowledge to make informed decisions or to be more aware during these pivotal times.Nicole Rincon https://www.nicolerincon.com/nicole-rinconRossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdfTACA Talks: https://www.nicolerincon.com/videosX: https://x.com/NicoleRinconPAPublications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articlesOther Resources: Autism and the Embryo, and expanding Artificial Light as a possible cause of Autismhttps://www.youtube.com/watch?v=NOVp4mIroug(See 18:36)https://www.youtube.com/watch?v=OtA-aMN7ziYDISCLAIMER: THIS IS NOT MEDICAL ADVICE.0:00 Nicole Rincon1:00 Understanding Pre-Pregnancy Risks4:02 Maternal Risks Factors for Autism6:53 Environmental Factors for Autism9:56 Alternatives to Common Medications12:58 The Role of Light & Seasonal Factors16:02 Serotonin & Autism18:56 Inflammation & Mitochondria22:08 Infections & Antibiotics25:08 Lab Work & Biomarkers for Maternal Health27:46 Tyrosine, Thyroid, & Iodine; Depression, Fatigue31:07 Folate & Methylation in Pregnancy; Autoimmune; Pregnancy Complications40:40 Amino Acids; Dietary Types & Autism; Personal Diets49:00 Eating Seasonally & Locally51:01 Post-Pregnancy Nutrition54:00 Breastfeeding versus Formula Feeding; Environmental Factors & Toxins, Plastics, Water1:00 The Role of Sunlight on Human Biology; Leptin & Hormones, Metabolism Accountant; Red Light1:02 Sun and Sunscreen; Beta-Endorphins, Cannabinoids, Hormones1:07 Concluding Thoughts on Health & FamilyX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

This episode was recorded before July 31, 2024. Professor Marcus Maurer and Dr Sigurd Broesby-Olsen discuss similarities and differences between urticaria and mastocytosis, two mast cell diseases. They then turn their attention to treatment, sharing their thoughts on ‘killing' mast cells and the development of more targeted and less toxic therapies. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell-mediated diseases; Mast cell–targeting therapies in mast cell activation syndromes; and Tyrosine kinase inhibitors for the treatment of indolent systemic mastocytosis: Are we there yet? Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria' podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

Viral vectors are a cornerstone of gene therapy and many employ experts in the viral vector services space to help design and produce their specialty vectors. These service providers are experts at making sure you get the vector you want with a titer and purity you need for your application. We're joined in this episode by Dr. Cliff Froelich, Head of Analytical Development for a viral vector services provider. Cliff and his team work with AAV, lentivirus, and other vectors to support multiple, and simultaneous, client projects. Specifically, we dive into how they use various analytical and molecular methods to monitor and assess identity, strength, purity, impurities, potency, efficiency, empty/full ratios, safety, and more. As you might expect, it's not a one-method-does-it-all approach or solution. Yes, digital PCR is in the mix here, and Cliff does a great job of outlining where it shines relative to the other methods they use regularly in their GMP practice. In our career corner portion, you'll hear about Cliff's circuitous career path, which includes stints in the poultry industry and time as a clinical dietitian. Through it all, and into his current role, Cliff brings a passion and genuine interest for the science and its potential to affect lives. Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog If you have hypothyroidism (Low thyroid), fibrocystic breasts, fatigue, metabolic syndrome, diabetes, hair loss, obesity, or high cholesterol then taking supplemental Iodoral can improve these diseases.  These conditions have become an epidemic in the United States due to Iodine deficiency. My longevity medical practice is all about keeping my patients healthy so they can live not only a longer life but one with quality. In the last 20 years of my BioBalance® Health practice, I have seen a flood of new patients with conditions that are in part secondary to iodine deficiency.  Today in America, the majority of people need iodine and other supplements to their diet for many reasons: Food manufacturers don't supplement our foods as they did in the years from the 1940s to 2000. The food that we eat (even fresh food) contains less nutrition than they did 50 years ago. Fast food diets, processed foods and preservatives remove necessary vitamins and minerals that we need to be healthy. Alcohol leaches nutrients from our bodies and alcohol consumption is increasing. Chemical pollution has entered our food supply and now is stored in our bodies. We have added a chemical to our drinking water, fluoride, which displaces Iodine in our bodies leaving us Iodine deficient. Today I am going to address the symptoms and diseases of Iodine deficiency. This blog about Iodine is to inform you about the need for Iodine and what it does.  I hope to never have to remind my patients about taking this supplement again after listening to the associated podcast or reading this blog! Iodine is a micronutrient necessary for life. In a research article in the Journal, Frontiers of Nutrition, March 2024, a very succinct review of the illnesses that occur because of iodine deficiency and that can be treated (partially) with iodine supplementation. I recommend all of my patients who live in my area which has no iodine in the soil or ground water and where all the drinking water is fluorinated.  The Iodine supplement, Iodoral, is not a drug, but a nutritional supplement that is sold over the counter. The Iodoral 12.5 mg bottle of 90 is $14.50 for 3-6 months supply.  You can't afford NOT to take it! Why do we need this supplement at this time in America and many first world countries?  Governmental intervention in our basic need for water caused most of our deficiencies.  Iodine is produced naturally in the ocean by seaweed, and it is contained in the soil and ground water in areas of the country that are near the ocean and those areas that were covered by ocean water millions of years ago. So, if you think geographically, most of the US is in that “map”, except the Midwest.  However, man and government has intervened and caused our population to be iodine deprived by adding Fluoride to our water. The government and the FDA make decisions for us without looking at the subsequent damage that might be done by those decisions. In the 1949 the US government decided that EVERYONE needed to be protected from dental cavities so 75 years ago we fluorinated our water and that decision led to the epidemic of iodine deficiency. Fluoride in your drinking and cooking water literally replaces iodine, and takes its place molecularly, leading to generations of people with 25% fewer cavities and 100% increase in the list of diseases I have listed in the first paragraph!   Fluoride is the biggest cause of thyroid disease. Wouldn't it be better to use fluoride toothpaste once a day than drink it? In some areas of the country, called the “Goiter Belt”, we don't have any iodine in the natural ground water, so locally grown food does not contain Iodine.  These regions have had a history of high percentage of the population with low thyroid, and goiters, even before we added fluoride to drinking water.  This compounds the problem and the diseases from Iodine deficiency. I live in that area! Before the 1970s iodine was required to be added to bread, salt and a few other foods. Ever since I have been seeing more Eating designer salt has caused people to not even get iodine in the salt they eat,  Now we use all kinds of salt most of which don't have iodine in them,. So now you know what the problem is today as well as the answer, Iodine supplementation with Iodoral® every day! How do you know if you have low Iodine and or Hypothyroidism? Symptoms of low iodine mirror those of low thyroid: fatigue, swelling, Abdominal bloating and pain Constipation hair loss and broken frizzy hair, brittle nails, dry skin, cold body temperature BBT less than or equal to 98 degrees Fahrenheit, weight gain, depression, slow metabolism, slow pulse low BP fibrocystic breasts So what will taking Iodoral® do for you beyond reversing the symptoms above? Improved thyroid function which decreases fatigue, weight gain, hair loss, brittle nails, swelling, and slow metabolism…. The benefits to you and your thyroid gland are immense! Your thyroid hormones control your metabolism and control your thermostat. Every cell in your body requires thyroid, and therefore require Iodine.  If your body doesn't have enough heat, then your enzymes can't work and our cells can't do their jobs, heal themselves and skin, muscles and all our tissues suffer. How does that work? Thyroid hormones T1, T2, T3, and T4  are made from one amino acid, Tyrosine, an 1-4 Iodine molecules!  The molecular structure of Iodine calls for plenty of iodine nutrient in the blood stream to make thyroid hormones and  to attach to iodine receptors on each cell that uses thyroid in your body. Preserve the health and function of your thyroid gland. You will feel warmer, your pulse and blood pressure will normalize. You will lose weight. Your thyroid hormone keeps your body warm by stimulating mitochondria to burn calories.  In this way thyroid hormone controls your weight, how fast you burn calories, how energetic you are, how well you think, how your hair and nails grow just to name a few benefits of thyroid. You need to add iodine to your diet to produce thyroid hormones to maintain all these vital functions for you! Prevention of Fibrocystic Breast Disease. Women's breasts absorb a lot of iodine and need Iodine to be healthy. The absorption by the breasts of iodine steals I from the thyroid and accounts for women having a much higher incidence of Hypothyroidism.  The thyroid is starved without iodine and “dies”.  Hypothyroidism is a Woman's disease! Fibrocystic Breast Disease. Women's breasts are iodine sensitive and years of low Iodine can cause Fibrocystic Breast Disease. This is not a precancerous condition, but it makes it harder to find a cancer in a breast on a mammogram. Weight Loss/Avoid Metabolic Syndrome For both sexes Iodine is needed to maintain blood sugar control and the control of obesity.  It is one of the necessary nutrients when it comes to weight loss.  More importantly it can prevent Metabolic syndrome which is a combination of high blood sugar (diabetes/prediabetes), obesity, hypertension, and high cholesterol. If you have Metabolic Syndrome, you are at higher risk for Cancer, Heart Disease, Stroke, and early Death.  It doesn't take just iodine to treat this syndrome once you have it, but Iodine is key to making your medical treatments, diet, and exercise work to decrease your medical risks of disease and early death. Lower your LDL Cholesterol Hypothyroidism causes an increase in LDL Cholesterol; therefore it may increase the incidence of heart disease. Organ Systems Other than the Thyroid Need Iodoral: As you can see by the list above, vital organs other than the thyroid accumulate/store Iodine: salivary glands, stomach, pancreas, ovary and testes, which has led to the new realization that Iodine has effects outside of the thyroid. Other Results of Replacing Iodine to what is clinically considered a high level in the US. Blood sugar is lowered by adequate Iodine blood levels (199-299 mcg/L). Insulin resistance is improved by taking Iodoral Hypertension lowered to its lowest point when blood levels were between (300-499) Gout: the higher the iodine, the lower the uric acid in the blood, therefore fewer Gout attacks. Mortality rates increase to 33-75% higher in people with low iodine levels. Inflammation and inflammatory diseases improve with iodine supplementation Immune modulation is one of the benefits of iodine. If you have a poor immune system, it improves your resistance to communicable diseases. If you have autoimmune disease Iodine improves these diseases. How could supplementing Iodine, removing Fluoride, from our drinking water do for us individually and our country? Japan is an example of high Iodine levels that benefit health.  What happens in other countries with adequate iodine levels?  Japan has the highest level of iodine in the blood because they consume seaweed in their diet and most of their water and food has iodine in it. Of course, Japan is an island surrounded by iodized seawater! They consume 7 x the average amount of Iodine as Americans with healthy consequences. Japan has one of the lowest incidences of Metabolic syndrome and the diseases included in it.  A study on Iodine consumption revealed that obese women had a significant weight loss when eating food in Japan. Summary: We all need iodine in our food and water or if we can't get it, we must supplement it with an over the counter supplement, Iodoral ½-1 tablet a day (12.5 mg tablet). The “normal” reference ranges are skewed to the low iodine level, so many people stop taking iodine when they follow the reference ranges, however in this research paper the ideal blood levels were considered healthy up to 100- 399mcg/L while the Quest and Labcorps reference ranges are 52-109, much lower than what is considered healthy by research studies. Iodine does not cause hyperthyroidism, however if someone has hyperthyroidism there is controversy as to whether Iodine should be supplemented. Make your choice: Health with an inexpensive supplement (Iodoral) or illness with fluoride and without Iodine.

Dans cet émission spéciale de Nutricast, Alexia Mannarino, experte en communication scientifique chez NHCO Nutrition, partage des insights précieux sur des méthodes innovantes et basées sur la science pour une gestion du poids efficace et durable. Loin des régimes restrictifs et des promesses de résultats instantanés, ce podcast aborde la perte de poids sous l'angle de la micronutrition et des ajustements alimentaires raisonnés. Alexia met en lumière l'importance de substances spécifiques telles que la N-Acétyl-Cystéine et le Chardon-Marie dans le cadre d'un programme détox initial, suivi par une rééquilibration de l'alimentation avec des actifs comme le Tryptophane et la Tyrosine, essentiels pour réguler l'appétit et les émotions. Elle discute également de l'optimisation du métabolisme à travers des éléments comme le Thé vert et l'Arginine, dévoilant comment ces composés peuvent augmenter la thermogenèse et la consommation d'énergie corporelle. Ce podcast est une ressource incontournable pour tous ceux qui cherchent à comprendre les mécanismes sous-jacents de la perte de poids et à intégrer des approches nutritionnelles avancées dans leurs pratiques. Alexia propose une vision complète et éclairée sur comment des interventions ciblées et personnalisées peuvent transformer la gestion du poids. Écoutez pour explorer comment ces ingrédients clés peuvent vous aider à atteindre une santé optimale et une silhouette idéale sans compromettre votre bien-être. Bonne écoute :-)

Listener feedback link: https://form.jotform.com/240459204544050 Kunwar Jung-KC and Alba Tristán-Noguero discuss tyrosine hydroxylase deficiency and explain how the tyrosine hyodroxylase cofactor, BH4, has shown early therapeutic potential in human neurons and a knock-in mouse model. Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock-in mouse model Kunwar Jung-KC, Alba Tristán-Noguero, et al https://doi.org/10.1002/jimd.12702

Veteran holistic physician Dr. Bradley Nelson (D.C., ret.) is one of the world's foremost experts on natural methods of achieving wellness. He is the creator of The Emotion Code and The Body Code system, and the CEO of Discover Healing, a holistic education platform that provides training and certifies practitioners worldwide. His bestselling book "The Emotion Code" provides step-by-step instructions for working with the body's energy healing power. His new book is “The Body Code: Unlocking Your Body's Ability to Heal Itself" Topics covered in this episode:Personal DevelopmentMeditation BenefitsEmotional Release TechniquesOvercoming Negative ThoughtsGratitude PracticeSubconscious MindMorphic Field ConceptBody Code and Emotion CodeTrapped Emotions & Heart WallsTo learn more about Dr. Bradley Nelson and his work, head over to www.discoverhealing.com__________________________________________________________While a lot of medical professionals say that adrenal fatigue is not a real thing, we know that the adrenal glands produce cortisol and other hormones to help regulate our stress response. To shop my protocol for stress and support of the adrenals, head to http://www.lindseyelmore.com/adrenals to see my combination of Rhodiola, Tyrosine, B Vitamins, Mag Glycinate, Ashwagandha and Vitamin D3__________________________________________________________We hope you enjoyed this episode. Come check us out at https://www.spreaker.com/show/the-lindsey-elmore-show

Where do you begin with mast cell disease treatment when there is such variation among patients?  Dr. Milner is back with us to discuss the difficulties in treating mast cell activation syndrome and mastocytosis. We will discuss the different approaches to treating mast cell disease and the medications used for mastocytosis treatment. Since no single treatment plan works for everyone, we will explore multiple strategies that can be helpful in managing this condition. A note: when you hear MCAS mentioned, it stands for Mast Cell Activation Syndrome. What we cover in our episode about treating mast cell diseases: What are the steps taken to treat mast cell diseases? Histamine blockers: antihistamines for mast cell disease and H2 blockers Mast cell stabilizers: Cromolyn and Ketotifen Xolair  Other medications that have been used but not recommended: aspirin, steroids, Singulair Epinephrine and anaphylaxis Tyrosine kinase inhibitors (TKI) for Mastocytosis: Avapritinib, Midostaurin Safety concerns and side effects of Tyrosine kinase inhibitors  Multidisciplinary approach to managing mast cell disease About our guest - Dr. Josh Milner Joshua Milner, MD, is a renowned leader in discovering and understanding genetic diseases leading to allergic symptoms, including Hereditary Alpha Tryptasemia Syndrome, PLAID, PGM3 deficiency, ERBIN mutation, and others. With a background in biology from MIT and an MD with distinction in immunology from Albert Einstein College of Medicine, Dr. Milner has extensive experience in pediatrics and allergy and immunology, serving as chief of the Laboratory of Allergic Diseases at NIAID. His vision is to leverage genetic variation to improve diagnosis and care for patients with allergic diseases through comprehensive genetic sequencing and functional studies, aiming for personalized medicine and interdisciplinary collaboration in pediatric allergy, immunology, and rheumatology. More about Dr. Milner:  https://www.pediatrics.columbia.edu/profile/joshua-milner-md More resources about mast cell disease: Mast Cell Disease Overview: https://allergyasthmanetwork.org/health-a-z/mast-cell-diseases/ What is Anaphylaxis? https://allergyasthmanetwork.org/anaphylaxis/ What is Epinephrine? https://allergyasthmanetwork.org/anaphylaxis/what-is-epinephrine/ The Mast Cell Disease Society: https://tmsforacure.org/ FDA Approves AYVAKIT® (avapritinib) as the First and Only Treatment for Indolent Systemic Mastocytosis: https://ir.blueprintmedicines.com/news-releases/news-release-details/fda-approves-ayvakitr-avapritinib-first-and-only-treatment

After a brief update on amino acid supplements, Phil and Lonnie cover breaking news on the billionaire-backed, (drug-) Enhanced Games. Are these Peter Thiel-funded events a viable alternative to the Olympics? Brace yourself for frank discussion on PEDs! -------- Donate to the show: https://www.paypal.com/donate/?hosted_button_id=3J6ZFPPKG6E6N Subscribe at Apple iTunes: https://podcasts.apple.com/us/podcast/nutritionradio-org/id1688282387  Podcast on Spotify: https://open.spotify.com/show/1ECHrnjxjn33DBNWgErPtp Subscribe to our YouTube backup: https://www.youtube.com/lonman07?sub_confirmation=1 Podcast on Amazon/ Audible: https://www.audible.com/pd/NutritionRadioorg-Podcast/B0BS8LFLLX?qid=1675812257&sr=1-1&ref=a_search_c3_lProduct_1_1&pf_rd_p=83218cca-c308-412f-bfcf-90198b687a2f&pf_rd_r=YKEZ8DX192TQF0CQV8KX&pageLoadId=u3x6bJ1 Podcast network web site: https://sites.libsyn.com/455769/site IronRadio-only site: https://www.ironradio.org/ 

Links mentioned in Episodewww.betterwithcarbo.com/2 - The Smart Approach: 5 Questions to ask yourself Before Trying SupplementsStress, Neurotransmitters, and Inflammation:Overview of the relationship between stress, neurotransmitters (adrenaline, norepinephrine, cortisol), and inflammation.Explanation of how prolonged stress leads to elevated levels of inflammatory cytokines and cortisol, potentially causing health problemsHPA Axis and Cortisol Tolerance:Detailed explanation of the Hypothalamus-Pituitary-Adrenal (HPA) axis and how chronic stress can lead to cortisol tolerance.Emphasis on the role of cortisol in controlling sleep, breaking down glucose, and suppressing the immune system.CRH and Gut-Brain Axis:Introduction to corticotropin-releasing hormone (CRH) triggered by stress and its impact on gut health.Discussion of how chronic stress can lead to leaky gut and inflammation through CRH.Main Points: Nutrients to Combat Stress and InflammationL-Theanine:Explanation of L-theanine as an amino acid found in tea leaves.Detailing L-theanine's ability to enhance GABA, serotonin, and dopamine production for relaxation.Suggested tea sources and timing for optimal benefits.Tyrosine:Overview of Tyrosine as an amino acid essential for neurotransmitter production.Emphasis on its significance during periods of high stress.Tyrosine-rich food sources and their incorporation into the diet.Magnesium:Explanation of magnesium's role in stress management at the cellular level.Highlighting its involvement in regulating the HPA axis and potential depletion during high stress.Magnesium-rich food sources and creative ways to include them in the diet.Probiotics:Introduction to the gut-brain axis and the bidirectional communication between gut and brain during stress.Importance of probiotics in supporting gut health, reducing inflammation, and improving mood.Probiotic-rich food sources and their incorporation into the diet.B Vitamins:Overview of the significance of B6, B9, and B12 in neurotransmitter production and myelin maintenance.Importance for individuals with conditions like MS.B vitamin-rich food sources and practical ways to include them in the diet.Vitamin C:Detailing Vitamin C's role as a cofactor for neurotransmitter synthesis during stress.Encouragement to consume Vitamin C-rich foods to support mood improvement.Vitamin C-rich food sources and delicious ways to incorporate them.Choline:Explanation of Choline's role in brain health, neurotransmitter function, and cell wall integrity.Importance of Choline-rich foods in supporting cognitive and emotional balance.Choline-rich food sources and creative ways to include them in the diet.Omega-3 Fatty Acids:Introduction to the anti-inflammatory effects of Omega-3 fatty acids.Connection between Omega-3s and reducing the production of inflammatory cytokines.Omega-3-rich food sources and simple ways to include them in the diet.Vitamin D:Emphasizing the role of Vitamin D in making the brain more efficient at managing stress.Importance of maintaining adequate Vitamin D levels.Vitamin D-rich food sources and the role of sun exposure.Follow along: https://betterwithcarbo.com/ Instagram

Have you ever wondered what drives your decisions, what fuels your motivation to stick to a workout plan, or why certain foods seem irresistible? The answer might surprise you – it's all about a powerful brain chemical called dopamine. This neurotransmitter plays a crucial role in our everyday behavior and choices, often without us even realizing it. In this article, we'll delve into how dopamine influences your adherence to exercise and nutrition programs, what causes its levels to fluctuate, and, most importantly, what you can do to optimize dopamine levels for better health and well-being. As a health and fitness enthusiast, you might already know that maintaining a healthy lifestyle isn't just about willpower – it's about understanding and working with your body's natural processes. That's what we aim to uncover here. So, whether you're looking to boost your motivation, improve your mood, or simply understand your body better, you're in the right place. Let's dive into the world of dopamine and discover how this crucial neurotransmitter can be your ally in achieving your health and fitness goals. What is Dopamine? - Understanding the Basics Dopamine, often referred to as the "feel-good" neurotransmitter, is a chemical messenger vital for conveying signals in the brain. It's produced in various parts of the brain, including the substantia nigra and the ventral tegmental area.Schultz, W. (2007). Multiple dopamine functions at different time courses. Annual Review of Neuroscience, 30, 259-288. But dopamine is more than just a messenger of pleasure; it's a critical component in your ability to think, plan, focus, and find things interesting. The production of dopamine starts with the amino acid tyrosine. Tyrosine undergoes a series of transformations, eventually becoming dopamine. Once produced, dopamine travels through different pathways in the brain, each influencing various aspects of behavior and physical function.Wise, R. A. (2004). Dopamine, learning and motivation. Nature Reviews Neuroscience, 5(6), 483-494. Interestingly, dopamine is not just confined to the brain. A substantial portion is also produced in the gut. This gut-derived dopamine is pivotal in regulating gastrointestinal motility and ensuring the proper functioning of the digestive system.Eisenhofer, G., Aneman, A., Friberg, P., Hooper, D., Fåndriks, L., Lonroth, H., … & Lundberg, J. (1997). Substantial production of dopamine in the human gastrointestinal tract. Journal of Clinical Endocrinology & Metabolism, 82(11), 3864-3871 The gut-brain axis, a communication network linking the gut and the brain, suggests that the dopamine produced in the gut could also have indirect effects on mood and behavior.Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2), 203. Dopamine doesn't work in isolation. It interacts with neurotransmitters like serotonin and norepinephrine, creating a delicate balance affecting everything from your mood to your motor skills.Carlsson, A. (1959). The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacological Reviews, 11(2), 490-493. In general, dopamine is central to motivating behavior by signaling the anticipation of a reward. It's involved in various functions, including memory, attention, mood, learning, and even motor control.Berridge, K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Research Reviews, 28(3), 309-369. Dopamine's Influence on Exercise and Nutrition Adherence As we've seen, dopamine is a key player in the brain's reward system. But how exactly does this translate to our exercise and nutrition habits? Exercise-induced dopamine release creates a feedback loop in your brain. When you exercise,

Ever wondered why ADHD makes meal planning feel overwhelming for so many of us? This week we're looking at what happens when our executive functions are put to the test with organising meals and cooking - whether that's just for one or for many.There's no need for any shame. It's about using your amazing brain differently, adding scaffolding and strategies, bringing a team on board (by stealth if necessary) and making use of things that will make daily life easier. Connect with Katherine here:WebsiteInstagramTiktokFacebookYoutubeLinkedINThreads https://www.bda.uk.com/find-a-dietitian.htmlhttps://www.bda.uk.com/resource/dietetics-in-avoidant-restrictive-food-intake-disorder-arfid.htmlhttps://www.arfidawarenessuk.org/treatmentBergwerff CE, Luman M, Blom HJ, Oosterlaan J. No Tryptophan, Tyrosine and Phenylalanine Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder. PLoS One. 2016 Mar 3;11(3):e0151100. doi: 10.1371/journal.pone.0151100. PMID: 26938936; PMCID: PMC4777504.Aarts E, Ederveen THA, Naaijen J, Zwiers MP, Boekhorst J, Timmerman HM, Smeekens SP, Netea MG, Buitelaar JK, Franke B, van Hijum SAFT, Arias Vasquez A. Gut microbiome in ADHD and its relation to neural reward anticipation. PLoS One. 2017 Sep 1;12(9):e0183509. doi: 10.1371/journal.pone.0183509. PMID: 28863139; PMCID: PMC5581161.Nigg, J. T., & Holton, K. (2014). Restriction and elimination diets in ADHD treatment. *Child and Adolescent Psychiatric Clinics*, 23(4), 937-953. [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322780/)Howard, A. L., Robinson, M., Smith, G. J., Ambrosini, G. L., Piek, J. P., & Oddy, W. H. (2011). ADHD is associated with a "Western" dietary pattern in adolescents. *Journal of Attention Disorders*, 15(5), 403-411. [Link](https://journals.sagepub.com/doi/10.1177/1087054710365990) Rucklidge, J. J. (2010). Food for thought: can nutrition improve behaviour in ADHD? *Journal of Child Psychology and Psychiatry*, 51(2), 130-133. [Link](https://acamh.onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7610.2009.02180.x)Pelsser, L. M., Frankena, K., Toorman, J., & Rodrigues Pereira, R. (2017). Diet and the role of food allergy in ADHD. *European Child & Adolescent Psychiatry*, 26(3), 355-372. [Link](https://link.springer.com/article/10.1007/s00787-016-0906-3)Ramsay, J. R. (2017). Cognitive behavioral therapy for adult ADHD: An integrative psychosocial and medical approach. *Routledge*. [Link](https://www.taylorfrancis.com/books/mono/10.4324/9781315744834/cognitive-behavioral-therapy-adult-adhd-j-russell-ramsay)Murphy, K., & Young, P. C. (2005). The role of family in dealing with ADHD. *Journal of Family Practice*, 54(10), 891-894....

Sally Adee is a freelance science writer in London. After a decade editing and writing science news and features for science and engineering magazines, she left magazine journalism to write a book on the history and future of biological electricity. We Are Electric looks at the myriad ways our cells and organs and selves are electric, and why we don't know more about them. Topics covered in this episode:BioelectricityHistorical PerspectiveNeuroscienceTools and InstrumentsGut-Brain AxisArtificial IntelligenceBrain-Computer InterfacesAging and BioelectricityRegenerationEnergy Medicine and Aging TherapiesTo learn more about Sally Adee and her work, head over to https://www.sally80.com/__________________________________________________________If you're looking for fast acting in long lasting pain relief that helps with sports recovery, joint discomfort and stiffness, as well as being able to enjoy all of your favorite activities, my favorite supplement that I use to support the bodies natural pain responses help us to balance amatory function and use a special technology that helps to ensure efficient absorption and faster Relief Plus.Relief Plus from Amari have been scientifically shown to help improve sports recovery and joint health specifically, reduce joint stiffness within three days, reduced joint discomfort within five days and an increase range of motion within seven days simply take one to three capsules ounces of water and if you are having a particularly bad day you can use up to four doses of three capsules each.Head to www.lindseyelmore.com/amari grab some Happy Juice and then bundle with Relief Plus to get all of the cortisol lowering benefits, the serotonin raising benefits and the dopamine modulating benefits of Happy Juice along side the fast acting and long long lasting pain relief of Relief Plus.  Head to www.lindseyelmore.com/amari and get $10 dollars off of your first order. __________________________________________________________While a lot of medical professionals say that adrenal fatigue is not a real thing, we know that the adrenal glands produce cortisol and other hormones to help regulate our stress response.  To shop my protocol for stress and support of the adrenals, head to http://www.lindseyelmore.com/adrenals to see my combination of Rhodiola, Tyrosine, B Vitamins, Mag Glycinate, Ashwagandha and Vitamin D3____________________________________________________________________________________________________________________We hope you enjoyed this episode. Come check us out at www.lindseyelmore.com/podcast.

This episode of Conversations for Health features Gray Area Drinking expert Jolene Park.  Jolene stopped drinking in 2014 and has studied the functional impact of food, emotions, environments, and movement in relationship to our physical bodies, which she speaks about in her TED talk about gray area drinking. She founded Healthy Discoveries in 2001 and created Craving Brain private coaching for individuals, the Sober Choice online course for the public, and the NOURISH Method training program for coaches and healthcare practitioners who would like to specialize in Gray Area Drinking Coaching.   In our conversation, Jolene addresses the key characteristics of gray area drinking. She offers tactics for practitioners who are supporting patients and clients as they evaluate their alcohol intake, including the questions to ask patients that will quickly and accurately assess their alcohol consumption. She highlights her personal experience with quitting alcohol, the supplements that helped her through the process, and the positive impact that sobriety has had on her health. Jolene offers resources, information, and encouragement for practitioners as they guide patients through gray area drinking toward a healthier lifestyle.   I'm your host, Evelyne Lambrecht, thank you for designing a well world with us.   Key Takeaways:   [2:15] Jolene defines gray area drinking as the space between two extremes of drinking. [4:17] Alcohol use disorder varies from alcoholism in one very specific way. [6:24] Tactics for quickly identifying patients as gray area drinkers. [8:54] Key risk factors that contribute to drinking alcohol include stress in relationships, work, or sleep. [12:05] Inappropriate advice about stress management and alcohol recommendations from therapists. [15:38] Jolene's personal experience with quitting alcohol consumption. [19:00] 80% of Jolene's clients are healthcare experts including therapists, naturopaths and nutritionists, and doctors. [20:40] The physiological response to alcohol intake and comparable substitution options. [25:00] The biggest change that Jolene has seen in her own health since abstaining from alcohol. [27:04] A comprehensive approach to supporting gray area drinkers in their non-drinking journey. [30:09] Supporting healthy neurotransmitters with nutrients and supplements. [33:10] The negative impact of alcohol on perimenopause and menopausal women. [35:00] Nutrient recommendations including inositol and Jolene's favorite herbs for anxiety support. [37:15] Additional tools including Dr. Braverman's personality questionnaire and tactics for living sober in an alcohol prominent environment. [44:33] Making connections between anxiety, overall health, and drinking alcohol. [47:28] Reframing the decision not to drink in a way that makes you feel empowered. [49:20] Jolene's personal favorite supplements, favorite health practices, and her new opinion on beans. [55:00] Jolene's practitioner training program and resources for practitioners who want to guide patients through gray area drinking.   Episode Resources:   Jolene Park   Gray Area Drinkers   Gray Area Drinking TED Talk   Dr. Braverman's Personality Questionnaire   Design for Health Resources:   Designs for Health   Blog: Alcohol and Nutrient Depletion   Blog: Impacts of Stress, Sleep, and Loneliness on Immune and Mental Health   Blog: GABA, Tyrosine, and Taurine: Amino Acids to Support a Healthy Mood   Blog: Recent Review Explores Potential Link Between Inositol and Mood Health   Blog: Lemon Balm and Its Many Uses   Blog: April Showers Bring May Flowers   Blog: The Calming Properties of L-Theanine Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.

Board-certified, Dr. Tom Hecker's concentration is on non-surgical treatments that help you feel and be like new – not just better.With a personal and educational approach, Dr. Hecker provides sports and regenerative medicine for people of all ages, abilities, and incomes. Dr. Hecker graduated from Colorado State University in Fort Collins before completing his Doctorate in Podiatric Medicine degree from the Dr. William M. Scholl College of Podiatric Medicine in Chicago. He completed a two-year podiatric surgical residency at St. Mary's of Nazareth Hospital in Chicago, before moving into private practice in 1996. Since then, he has developed effective non-surgical strategies and treatments for all types of biomechanical injuries and chronic pain.Dr. Hecker is committed to continuing medical education, equipping him to provide the latest and up-to-date care for patients. Using the most recent advancement in diagnosis and treatment of all types of injuries, including foot and ankle problems, he provides help to renew patients' strength.Topics covered in this episode:Developmental Differences in FeetImpact of Shoes on Foot StructureBunions Joint ChangesThe Challenge of Going BarefootLack of Non-Surgical AlternativesSeeking Non-Surgical SolutionsTreating Various JointsThe Importance of Finding SpecialistsTo learn more about Thomas Hecker and his work, head over to https://www.heckersportsmed.com/IG @heckersportsmed__________________________________________________________If you're looking for fast acting in long lasting pain relief that helps with sports recovery, joint discomfort and stiffness, as well as being able to enjoy all of your favorite activities, my favorite supplement that I use to support the bodies natural pain responses help us to balance amatory function and use a special technology that helps to ensure efficient absorption and faster Relief Plus.Relief Plus from Amari have been scientifically shown to help improve sports recovery and joint health specifically, reduce joint stiffness within three days, reduced joint discomfort within five days and an increase range of motion within seven days simply take one to three capsules ounces of water and if you are having a particularly bad day you can use up to four doses of three capsules each.Head to www.lindseyelmore.com/amari grab some Happy Juice and then bundle with Relief Plus to get all of the cortisol lowering benefits, the serotonin raising benefits and the dopamine modulating benefits of Happy Juice along side the fast acting and long long lasting pain relief of Relief Plus.  Head to www.lindseyelmore.com/amari and get $10 dollars off of your first order. __________________________________________________________While a lot of medical professionals say that adrenal fatigue is not a real thing, we know that the adrenal glands produce cortisol and other hormones to help regulate our stress response.  To shop my protocol for stress and support of the adrenals, head to http://www.lindseyelmore.com/adrenals to see my combination of Rhodiola, Tyrosine, B Vitamins, Mag Glycinate, Ashwagandha and Vitamin D3____________________________________________________________________________________________________________________We hope you enjoyed this episode. Come check us out at www.lindseyelmore.com/podcast.

It is summer, and you know what that means. It is summer vacation. I am taking a couple of weeks off of recording the podcast, and that means that we get to drop some of my favorite episodes that you may or may not have ever listened to. These three interviews have such a dramatically different approach on how we can heal our mental health and truly become mentally well.Dr Joseph Yi is a board certified addiction psychiatrist based in Newtown, Pennsylvania. He has been in practice for over 17 yrs and has helped thousands of people in his community get off of prescription medications and empowers his clients to become the CEO's of their own health destiny through a more integrative approach to mental wellness. He is founder of Modern Behavioral, Beyond Recovery, and his Instagram has over 200K followers. His purpose and mission has been to help individuals all around to focus on mental wellness over illness.Topics covered in this episode:Purpose through RecoveryMental HealthPsychiatryHolistic Psychiatry4 Pillars of Mental WellnessInspiration & DesperationMisbehaviorTechnology AddictionDiets DopamineAdderallAddiction & DependencyTolerance & WithdrawalDose EscalationFentanylReferenced in the episode:The Lindsey Elmore Show Ep 184 | The Silent Epidemic Of Antidepressant Addiction and How to Truly Heal Anxiety | Ellen VoraTo learn more about Joseph Yi and his work, head over to www.Modernbehavioral.comIG @Yojimd__________________________________________________________It's hard to believe that summer is almost over and that fall is right around the corner. We know that when we have shorter days and longer nights, we have an increased risk of depression. There's no reason for somebody to live in sadness.  Head to http://www.lindseyelmore.com/depression to shop my full list of supplements that have been studied and researched for helping to mitigate sadness and depression. __________________________________________________________While a lot of medical professionals say that adrenal fatigue is not a real thing, we know that the adrenal glands produce cortisol and other hormones to help regulate our stress response.  To shop my protocol for stress and support of the adrenals, head to http://www.lindseyelmore.com/adrenals to see my combination of Rhodiola, Tyrosine, B Vitamins, Mag Glycinate, Ashwagandha and Vitamin D3  ____________________________________________________________________________________________________________________We hope you enjoyed this episode. Come check us out at www.lindseyelmore.com/podcast

Timothy McMahan King is a writer, Senior Fellow for Clergy for a New Drug Policy, and the owner of Vagabond Strategies. He is the former chief strategy officer for Sojourners and has served as a consultant for national non-profits, advocacy campaigns, and political candidates. The author of Addiction Nation: What the Opioid Crisis Reveals About Us (Herald Press, 2019), he is an active advocate for those in recovery and to reform United States drug policy. His second book, What Are Drugs For? is forthcoming with Fortress Press. He has written widely for national publications, including The Wall Street Journal and CNN. A nationally sought-after speaker, he explores the intersection of faith, science, drugs, and addiction while calling for an end to a culture of punishment. He hosts a monthly webinar series on addiction and drug policy issues for the Center of Addiction and Faith, where he also serves as a board member. A graduate of North Park University with degrees in theology and philosophy, McMahan Kinghas a deep interest in what healing looks like for the individual and our culture. Growing up on a farm in New Hampshire, he has a keen awareness of the ways in which our communities and the natural environment can call us into greater wholeness. McMahan King lives with his wife, Hannah, their daughter Ruth and their dog, Hank, in North Carolina. Topics covered in this episode:Healing and RecoverySubstance Use and AddictionHarm Reduction PhilosophyEmpathy and Compassion in HealthcareRole of Psychedelics in Addiction TreatmentCultural and Historical Context of Drug UseImpact of Drugs on Human ExperiencePlacebo Effect in TreatmentMind-Body Connection in HealingEthical Considerations in MedicineRole of Religion and Spirituality in Drug UseMental Health and Substance AbuseIntegrating Ancient Wisdom with Modern SciencePersonalized Approaches to TreatmentStigma and Judgment Surrounding Drug UseReferenced in the episode:The Lindsey Elmore Show Ep 202 | Drunk: Why We Drink and How It Civilized Us | Edward Slingerland To learn more about Timothy McMahan King and his work, head over to https://www.mcmahanking.com/IG @timothymcmahanking__________________________________________________________If you haven't been feeling like your best self, maybe you've been struggling with your metabolism and weight loss, or are just not in a good mood and are stressed out all the time, maybe your sex life isn't what it once was. Enter the Amare Happy Hormones Pack.If you wanna get going and try the Happy Hormones pack head to  http://www.learnamare.com/hormones between now and the end of July, when you shop the Happy Hormones Pack, you will also receive a free bottle of Omegas. Don't worry. If you're listening to this after the end of July, just go to http://www.lindseyelmore.com/amare to save $10 at any point.__________________________________________________________While a lot of medical professionals say that adrenal fatigue is not a real thing, we know that the adrenal glands produce cortisol and other hormones to help regulate our stress response.  To shop my protocol for stress and support of the adrenals, head to http://www.lindseyelmore.com/adrenals to see my combination of Rhodiola, Tyrosine, B Vitamins, Mag Glycinate, Ashwagandha and Vitamin D3____________________________________________________________________________________________________________________We hope you enjoyed this episode. Come check us out at www.lindseyelmore.com/podcast.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.550978v1?rss=1 Authors: GARNIER, O., JEANNERET, F., DURAND, A., FERTIN, A., MARTIN, D., BERNDT, S., CARPENTIER, G., BATTAIL, C., VILGRAIN, I. Abstract: Rationale: Phosphorylation-dephosphorylation are processes involved in the adhesion of endothelial cells (ECs) to maintain vascular integrity in adults. VE-cadherin is a target for Src -mediated Y685 phosphorylation, identified in highly vascularized human glioblastoma where it is involved in the abnormal feature of tumor blood vessels . Objective: We aimed at understanding the molecular mechanisms through which Y685F-VE-cadherin triggers S1PR1 gene expression and stabilizes lung vessels in adult mice. Methods and Results: We compared lung ECs from a knock-in (KI) mouse carrying a point mutation in VE-cadherin (Tyr 685 to Phe) to Wild type . Analysis of EC parameters showed a difference in the migratory rate was between ECs from KI (22.45% +/- 5.207) and WT (13.24% +/- 5.17) (p-value=0.034). The direct adhesion of ECs from KI mice to fibronectin was significantly higher (37.625 +/- 9.23) than that of the WT (26.8 +/- 3.258, p-value=0.012). In the fibrin bead assay, ECs from KI showed a weaker angiogenic response. The transcriptome of mutated ECs showed that 884 genes were dysregulated of which 766 genes were downregulated and 118 genes were upregulated. The Gene Ontology Enrichment showed that most of the genes were related to cell-cell adhesion and angiogenesis. Focusing on angiogenic genes, we found that Sphingosine-1-phosphate-receptor was a gene upregulated in mutated ECs which was confirmed by RT-PCR and westernblotting. Mechanistically, chromatin immunoprecipitation assay (CHIPS) demonstrated that FOXF1 directly bound to the S1pr1 promoter 7 fold greater than WT. As a consequence , VE-cadherin at the membrane was higher in the mutant vs WT (100 +/- 6.52 for WT vs 189.7 +/- 21.06 for KI (p-value 0.0001). Finally, lung morphometric analysis showed less vessels and vascular remodeling with no fibrosis in mutated mice. Conclusions: These data extend our knowledge on pY-VE-cadherin mediated pathological angiogenesis and provide new therapeutic opportunities to vascular normalization through pharmacological inhibition of the Y685-VE-cadherin phosphorylation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550379v1?rss=1 Authors: Stephens, E. B., Henke, W., Kalamvoki, M. Abstract: The open reading frame 3a (ORF3a) is an accessory transmembrane protein that is important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (Yxx{Phi}; where x is any amino acid and {Phi} is a hydrophobic amino acid with a bulky -R group). They have been implicated in the trafficking of membrane proteins to the cell plasma membrane and to intracellular organelles. Previous studies have indicated that mutation of the 160YSNV163 motif abrogated plasma membrane expression and inhibited ORF3a-induced apoptosis. However, two additional canonical tyrosine-based sorting motifs (211YYQL213, 233YNKI236) exist in the cytoplasmic domain of ORF3a that have not been assessed. We removed all three potential tyrosine-based motifs and systematically restored them to assess the importance of each motif or combination of motifs that restored efficient trafficking to the cell surface and lysosomes. Our results indicate that the Yxx{Phi} motif at position 160 was insufficient for the trafficking of ORF3a to the cell surface. Our studies also showed that ORF3a proteins with an intact Yxx{Phi} at position 211 or at 160 and 211 were most important. We found that ORF3a cell surface expression correlated with the co-localization of ORF3a with LAMP-1 near the cell surface. These results suggest that Yxx{Phi} motifs within the cytoplasmic domain may act cooperatively in ORF3a transport to the plasma membrane and endocytosis to lysosomes. Further, our results indicate that certain tyrosine mutants failed to activate caspase 3 and did not correlate with autophagy functions associated with this protein. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.11.548638v1?rss=1 Authors: Kasanga, E. A., Soto, I., Centner, A., McManus, R., Shifflet, M. K., Navarrete, W., Han, Y., Lisk, J., Wheeler, K., Mhatre-Winters, I., Richardson, J. R., Bishop, C., Nejtek, V. A., Salvatore, M. F. Abstract: Background: Alleviation of motor impairment by aerobic exercise (AE) in Parkinsons disease (PD) points to a CNS response that could be targeted by therapeutic approaches, but recovery of striatal dopamine (DA) or tyrosine hydroxylase (TH) has been inconsistent in rodent studies. Objective: To increase translation of AE, 3 components were implemented into AE design to determine if recovery of established motor impairment, concomitant with greater than 80% striatal DA and TH loss, was possible. We also evaluated if serum levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP), blood-based biomarkers of disease severity in human PD, were affected. Methods: We used a 6-OHDA hemiparkinson rat model featuring progressive nigrostriatal neuron loss over 28 days, with impaired forelimb use 7 days post-lesion, and hypokinesia onset 21 days post-lesion. After establishing forelimb use deficits, moderate intensity AE began 1-3 days later, 3x per week, for 40 min/session. Motor assessments were conducted weekly for 3 wks, followed by determination of striatal DA, TH protein and mRNA, and NfL and GFAP serum levels. Results: Seven days after 6-OHDA lesion, recovery of depolarization-stimulated extracellular DA and DA tissue content was less than 10%, representing severity of DA loss in human PD, concomitant with 50% reduction in forelimb use. Despite severe DA loss, recovery of forelimb use deficits and alleviation of hypokinesia progression began after 2 weeks of AE and was maintained. Increased NfLand GFAP levels from lesion were reduced by AE. Despite these AE-driven changes, striatal DA tissue and TH protein levels were unaffected. Conclusions: This proof-of-concept study shows AE, using exercise parameters within the capabilities most PD patients, promotes recovery of established motor deficits in a rodent PD model, concomitant with reduced levels of blood-based biomarkers associated with PD severity, without commensurate increase in striatal DA or TH protein. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Recently I've reacquainted myself with Tyrosine in the N-Acetyl L-Tyrosine (NALT) form, from PureBulk.com. Here I'll tell you a little about its subjective effects and will summarize the recent science done on this well-established Nootropic. As I mentioned in my meta-analysis of it, it's an intervention worth keeping in your Biohacker armamentarium for both moderate and severe sleep deprivation.Read review

To watch this as a video Download it and play it from the Downloads section in the Castbox app on your device.Recently I've reacquainted myself with Tyrosine in the N-Acetyl L-Tyrosine (NALT) form, from PureBulk.com. Here I'll tell you a little about its subjective effects and will summarize the recent science done on this well-established Nootropic. As I mentioned in my meta-analysis of it, it's an intervention worth keeping in your Biohacker armamentarium for both moderate and severe sleep deprivation.Read review

L'hypothyroïdie est un dérèglement de la glande thyroïde qui cause le ralentissement de son activité. Je partagerai avec vous l'alimentation que je vous préconise si vous êtes atteints d'hypothyroïdie, ainsi que les vitamines, minéraux et oligo-éléments indispensables à l'activité thyroïdienne. Je vous donnerai aussi des noms de plantes réputées pour leur activité pro-thyroïdienne pour vous aider à enrayer vos symptômes. On parlera également d'hygiène de vie, de stress, de sommeil et de perturbateurs endocriniens car ils peuvent tous impacter la bonne régulation de la glande thyroïde. Bonne écoute !

Steph Lowe is back for our part 2 on Thyroid health - diving deeper into Hashimoto's Thyroiditis - an autoimmune condition of the thyroid.  Steph explains how autoimmune and Hashimoto's begins in the body, root causes of Hashimotos, why Thyroxine medication isn't a solution, how to help put Hashimoto's iinto remiscion, why gluten is sabotaging your immune system, symptoms of sublinical hypothyroidism, why Selenium, Iodine, Zinc and Tyrosine as 4 key nutrients to be consuming and so much more. Steph Lowe is a mentor, podcaster (Health, Happiness & Human Kind) and on IG.

Go to https://thld.co/zbiotics_siim_0123 and get 15% off your first order of ZBiotics Pre-Alcohol Probiotic by using my code SIIM at checkout. Thanks to ZBiotics for sponsoring today's video! Timestamps: 01:11 Thoughts on L-Theanine 02:27 Glycine vs Inositol for Sleep 03:30 Is Viagra Longevity Drug? 05:00 Thoughts on Finasteride 07:50 Glycine with Methionine or Alone 08:36 Carbs First Or Protein First 10:25 Do I Use Nicotine 11:25 How Much Magnesium Can Your Body Absorb 12:52 L-Theanine vs Tyrosine 14:00 How to Increase HRV 16:00 Best Non-Dairy Calcium Sources 16:43 Potatoes Fried in Olive Oil - Good or Bad 18:00 Vitamin C and Garlic Pre-Workout 20:00 Best Vegan Protein Sources 20:57 Thoughts on Bryan Johnson 23:01 Negative Effects of Too Many Antioxidants 28:14 Knee Pain Rehab Exercises Get the Biological Age Test Kit + Consultation: https://www.siimland.co/offers/FZVrSHei

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.03.526966v1?rss=1 Authors: Surana, S., Villarroel-Campos, D., Panzi, C., Novoselov, S. S., Richter, S., Zanotti, G., Schiavo, G. Abstract: Tetanus toxin is one of the most potent neurotoxins and is the causative agent of tetanus. This neurotoxin binds to the neuromuscular junction and, after internalisation into motor neurons, undergoes long-distance axonal transport and transcytosis into spinal cord inhibitory interneurons. Inside the cytoplasm of interneurons, the catalytic chain of the toxin blocks neurotransmitter release, leading to spastic paralysis. Whilst the effects of tetanus toxin intoxication have been extensively studied, the molecular composition of its receptor complex is still poorly understood. We have previously shown that the extracellular matrix proteins nidogens are essential for binding of the toxin to the neuromuscular junction. In this study, we show that the tyrosine phosphatase LAR interacts with the nidogen-tetanus toxin complex and enables its uptake into motor neurons. Binding of LAR to the toxin complex is mediated by its fibronectin III domains, which we have harnessed to inhibit tetanus toxin entry into motor neurons. Surprisingly, this function of LAR is independent of its role in regulating the neurotrophic activity of the TrkB receptor, which has previously been shown to augment the axonal transport of signalling endosomes containing tetanus neurotoxin. These findings identify a multi-subunit complex acting as a protein receptor for tetanus neurotoxin, and demonstrate a novel endocytic trafficking route for extracellular matrix proteins in neurons. Our study paves the way for dissecting the molecular mechanisms that control the recognition and uptake of physiological ligands and pathological proteins at the neuronal plasma membrane, as well as their targeting to the axonal retrograde pathway for long-distance transport within the nervous system. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518437v1?rss=1 Authors: Kasanga, E., Han, Y., Shifflet, M., Navarrete, W., McManus, R., Parry, C., Barhona, A., Nejtek, V., Richardson, J. R., Salvatore, M. F. Abstract: Mechanisms that augment dopamine (DA) signaling to compensate for tyrosine hydroxylase (TH) loss and delay motor impairment in Parkinsons disease remain unidentified. The rat nigrostriatal pathway was unilaterally-lesioned by 6-OHDA to determine whether differences in DA content, TH protein, TH phosphorylation, or D1 receptor expression in striatum or substantia nigra (SN) aligned with onset of hypokinesia at two time points. At 7 days, DA and TH loss in striatum exceeded 95%, whereas DA was unaffected in SN, despite 60% TH loss. At 28 days, hypokinesia was established. At both time points, ser31 TH phosphorylation increased only in SN, corresponding to less DA versus TH loss. ser40 TH phosphorylation was unaffected in striatum or SN. By day 28, D1 receptor expression increased only in lesioned SN. These results indicate that increased ser31 TH phosphorylation and D1 receptor in the SN, not striatum, augment DA signaling against TH loss to mitigate hypokinesia. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518657v1?rss=1 Authors: He, X.-B., Guo, F., Zhang, W., Wu, Y., Le, W., Wang, H., Zhou, Q., Huang, H. Abstract: Regulation of dopamine (DA) biosynthesis is critical for the functionalities of midbrain DA neurons. Tyrosine hydroxylase (TH) is the rate-limiting enzyme for dopamine (DA) biosynthesis in midbrain DA neurons. Here we report that DA contents are decreased in the midbrain and striatum of DA neuron-specific JMJD3 conditional knockdown mice. Consistent results are obtained from mice underwent pharmaceutical JMJD3 inhibition. Biochemical and histological experiments reveal that TH mRNA and protein levels are specifically decreased in DA neurons residing in ventral tegmental area but not substantia nigra pars compacta. On behavioral level, JMJD3 knockdown affects inflammation-induced chronic mechanical hyperalgesia but not locomotor coordination, corresponding to DA-associated behavior in ventral tegmental area and in substantia nigra pars compacta, respectively. Mechanistically, using a midbrain DA neuron culture, we demonstrate that JMJD3 transactivates TH gene expression through direct binding onto TH promoter and catalyzing H3K27 de-methylation. In summary, our findings reveal a novel role of JMJD3 in adult midbrain DA system and suggest its functional specificity with DA subtype heterogeneity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Garder le moral, ce n'est pas toujours facile avec l'arrivée de l'hiver. Les jours se raccourcissent, le froid s'intensifie et le mauvais temps est plus fréquent. Cette saison de Be Lively vous apprend à chasser le négatif pour affronter les difficultés du quotidien et remettre un peu de soleil dans vos journées. Vous vous sentez un peu stressé-es ? Faites un tour du côté de la tyrosine ! Cet acide aminé compose les protéines et est constitutif des cellules de notre corps. Elle contribue au bon fonctionnement du système nerveux, à l'équilibre général et favorise l'entrain et la motivation. Mais alors, dans quels aliments la trouver ? Comment agit concrètement la tyrosine dans notre corps ? Tous les épisodes de Be Lively sont à retrouver ici. Learn more about your ad choices. Visit megaphone.fm/adchoices

These 6 nutrient deficiencies can cause hypothyroidism and low thyroid function if present. The good thing about these nutrients is that they can be targeted and replaced which means that you may be able to reverse your thyroid condition (assuming it was caused by a nutrient deficiency!). Not all cases of hypothyroidism are caused by nutrient deficiencies but taking these supplements can still help improve thyroid function in various ways. It's well known that certain vitamins and minerals are required for your thyroid to work correctly. So it makes sense that if you don't have enough of these nutrients that your thyroid won't work properly. If you replace them then you may be able to naturally increase how well your thyroid is working so that you can start feeling better. Some of these deficiencies can be subtle and may sneak up on you over time. Over time you may start to feel hypothyroid symptoms including weight gain, hair loss, dry skin, constipation, poor digestion, low body temperature, and other hormone problems. The nutrient deficiencies outlined in this video include: #1. Zinc #2. Iron #3. Iodine #4. Selenium #5. Tyrosine #6. Vitamin A Find out how to know if you are deficient in these vitamins, how to replace them using food or supplements, and much more in this video. Download my free thyroid resources here (including hypothyroid symptoms checklist, the complete list of thyroid lab tests + optimal ranges, foods you should avoid if you have thyroid disease, and more): https://www.restartmed.com/start-here/ Disclaimer: Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/what-happe... This video is for general informational, educational, and entertainment purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Childs and you. You should not make any changes to your medications or health regimens without first consulting a physician. If you have any questions please consult with your current primary care provider. Restart Medical LLC and Dr. Westin Childs are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video. #thyroid #hypothyroidism #hashimoto's

Visit us at shapedbydog.com     We're geeking out the topic of dopamine in dog training and how it impacts a dog's motivation. Dopamine is a type of  neurotransmitter, and there's a lot of research on its relation to the drive to seek out happiness. Now, you might be wondering what it has to do with dog training but to make sure our dogs want to work with us, it's something we need to know, and it relates directly to my training protocols and transfer of value.   In the episode you'll hear:   • How and when dopamine gets released in a dog's brain. • About an experiment by Robert Sapolsky on dopamine spikes with a cue, behaviour, and reward. • How a dopamine spike would relate to me and vegan chocolate chip cookies. • That dopamine relates to the transfer of value in dog training (the thing before the thing). • What the research shows about the difference between luring and shaping and dopamine. • About research on blocking dopamine and how it impacts motivation. • What a suppressed level of dopamine does and how that relates to dogs. • What I've noticed with my young dog This! and how I'm particular about her training. • About foods and supplements that support healthy dopamine production. • The effects of too much dopamine and what I observed with my dog Buzz. • How I give my dogs a calm walk once a week for a dopamine detox. • Why to look at your dog training to see if your dog is getting healthy dopamine spikes.   Resources:   1. Paper (PDF): A Neural Substrate of Prediction and Reward - Authors: Schultz, W.; Dayan, P.; Montague, P.R. - http://www.gatsby.ucl.ac.uk/~dayan/papers/sdm97.pdf 2. YouTube Video: Wolfram Schultz - Dopamine: from movement via reward to rational choice - https://youtu.be/pLqgakCXW5Q 3. YouTube Video: Dopamine Jackpot! Sapolsky on the Science of Pleasure - https://youtu.be/axrywDP9Ii0 4. Paper: Dopamine reward prediction error coding- Author: Wolfram Schultz, MD, FRS - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826767/ 5. Article: Why does the brain have a reward prediction error? – Author: Mark Humphries - https://medium.com/the-spike/why-does-the-brain-have-a-reward-prediction-error-6d52773bd9e7 6. YouTube Playlist: Reinforcement, Permissions and Transfer of Value in Dog Training with Susan Garrett - https://www.youtube.com/playlist?list=PLphRRSxcMHy1IUj_4P54q2PIuLNtnXjFO 7. Paper: Dopamine Modulates Effort-Based Decision-Making in Rats – Authors: Mark E. Bardgett, Melissa Depenbrock, Nathan Downs, Megan Points, Leonard Green - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791340/ 8. Book: Shaping Success by Susan Garrett - https://dogsthat.com/product/shaping-success-2/ 9. Watch this Episode of Shaped by Dog on YouTube - https://youtu.be/FMzI6VzIU_w

Sometimes nutritional deficiencies follow gut problems and sometimes they precede them. Learn how a lack of amino acids can impact your gut health, why gut issues, including H. pylori, may be leading to protein maldigestion, and how to turn things around. We also discuss iodine, pesticides in food, PPIs, Omega 3's and how to ensure adequate nutrition with David Minkoff, MD. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

Huberman Lab Podcast Notes Key Takeaways Adequate quality and duration of sleep and experiencing all the different stages of sleep (i.e., slow wave, REM) are important in optimizing metabolic circuits for health and performanceWhen done properly (i.e., sleeping and waking at roughly the same time, bright light exposure in the morning, dim lights in the evening, etc.) study participants experienced huge benefits in mood, stress, and grip strength (among other outcomes) when switching habits from “night owl” to “morning person”Four main neuromodulators: (1) dopamine; (2) epinephrine/adrenaline; (3) serotonin; (4) acetylcholineDifferent neuromodulators are naturally present at higher or lower levels in each phase of the day – leverage these natural fluctuations to optimize your focus and outcomes“Dopamine is not about pleasure, it's about motivation, craving, and pursuit for goals or things outside our immediate experience or possession.” – Dr. Andrew HubermanTools optimize dopamine: sunlight, caffeine, tyrosine, mucuna pruriens, L-tyrosine, phenylehtylamine, cold exposure, B vitaminsTools to optimize epinephrine: exercise, breathwork (cyclic hyperventilation), caffeineTools to optimize acetylcholine: foods rich in choline, nicotine (no, don't smoke cigarettes), alpha-GPC, huperzine, narrow visual fieldTools to optimize serotonin: physical touch, gratitude, tryptophan, cissus quadrangularis, 5-HTP, myo-inositolWhen trying any of the tools listed, start with the behavioral approach, then nutrition, then supplementation, then turn to the clinical/pharmaceutical approach if all else fails or there is a medical necessityRead the full notes @ podcastnotes.orgIn this episode, I explain the biological roles of the four major neuromodulators—dopamine, epinephrine (aka adrenaline), serotonin, and acetylcholine—and describe how these neuromodulators impact a wide variety of mental states and behaviors, including focus, creativity, motivation, drive, learning, alertness, mood, relationships, and feelings of well-being. Then, with that foundational understanding in mind, I describe a potent toolkit of science-supported behavioral, nutrition, and supplementation tools that can be used to increase baseline levels of individual neuromodulators and that can be modified for specific goals. This episode summarizes low-or-no-cost, actionable, science-based tools that can benefit anyone in order to enhance their levels of brain chemicals and improve mental health, physical health, and performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Optimizing Neurochemicals to Improve Health (00:03:40) Momentous Supplements (00:05:30) Sleep & Maintaining Healthy Metabolism (00:09:52) Tools: How to Wake Up Earlier, Night Owls (00:19:32) AG1 (Athletic Greens), Thesis, InsideTracker (00:22:05) Nervous System Overview (00:31:32) How Neuromodulators Work   (00:34:24) Baseline Neuromodulator Levels, 3 Daily Phases (00:42:15) Hormones Modulate Neuromodulators (00:52:12) The 4 Major Types of Neuromodulators (01:01:45) Tool Kit 1: Increase Baseline Dopamine & Focus (01:08:52) Tyrosine-rich Foods & Dopamine (01:10:59) Dopamine Supplementation: Mucuna Pruriens, L-tyrosine & Phenylethylamine (01:16:00) Deliberate Cold Exposure & Dopamine (01:21:12) Tool Kit 2: Additional Tips to Increase Dopamine (01:26:10) Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness (01:34:34) Tool Kit 4: Increase Acetylcholine & Attention/Learning; Choline-rich Foods (01:37:29) Acetylcholine Supplements: Nicotine, Alpha GPC, Huperzine   (01:44:47) Tool Kit 5: Behavior to Increase Focus & Acetylcholine (01:46:56) Tool Kit 6: Behavior to Increase Serotonin & Feelings of Well-being   (01:50:51) Tools: Tryptophan-Rich Foods & Serotonin (01:53:31) Tools: Serotonin Supplements: Cissus Quadrangularis, 5-HTP, Myo-inositol (02:02:14) Use the Neurochemical Toolkit to Meet Individual Goals (02:06:44) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

If you have a thyroid disorder, you might have heard/seen that you should eat sea moss or seaweed. However, could these iodine containing foods and/or supplements be part of the reason your thyroid is so off? The answer is- it very could be. Over the last few months, I've seen an increase in women taking iodine containing thyroid supplements, iodine containing multivitamins, and including more iodine rich foods. I've seen people lose their appetite and just not hungry to eat because they're not eating enough zinc rich foods. Our bodies like a good balance of certain vitamins/minerals and when they get off (too much or too little), it can negatively impact thyroid hormones. In today's episode at Nutrition's My Life, I'm helping you with 3 key thyroid supporting nutrients. 1. Tyrosine 2. Iodine 3. Zinc If you'd like to learn more about how to improve your thyroid's health and overall health, join me August 6th 2022 for a Thyroid Workshop. The Healthy Thyroid Guidance Workshop is open for enrollment - learn more https://www.nutritionsmylife.com/the-healthy-thyroid-guidance-workshop

In this episode, I explain the biological roles of the four major neuromodulators—dopamine, epinephrine (aka adrenaline), serotonin, and acetylcholine—and describe how these neuromodulators impact a wide variety of mental states and behaviors, including focus, creativity, motivation, drive, learning, alertness, mood, relationships, and feelings of well-being. Then, with that foundational understanding in mind, I describe a potent toolkit of science-supported behavioral, nutrition, and supplementation tools that can be used to increase baseline levels of individual neuromodulators and that can be modified for specific goals. This episode summarizes low-or-no-cost, actionable, science-based tools that can benefit anyone in order to enhance their levels of brain chemicals and improve mental health, physical health, and performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Optimizing Neurochemicals to Improve Health (00:03:40) Momentous Supplements (00:05:30) Sleep & Maintaining Healthy Metabolism (00:09:52) Tools: How to Wake Up Earlier, Night Owls (00:19:32) AG1 (Athletic Greens), Thesis, InsideTracker (00:22:05) Nervous System Overview (00:31:32) How Neuromodulators Work   (00:34:24) Baseline Neuromodulator Levels, 3 Daily Phases (00:42:15) Hormones Modulate Neuromodulators (00:52:12) The 4 Major Types of Neuromodulators (01:01:45) Tool Kit 1: Increase Baseline Dopamine & Focus (01:08:52) Tyrosine-rich Foods & Dopamine (01:10:59) Dopamine Supplementation: Mucuna Pruriens, L-tyrosine & Phenylethylamine (01:16:00) Deliberate Cold Exposure & Dopamine (01:21:12) Tool Kit 2: Additional Tips to Increase Dopamine (01:26:10) Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness (01:34:34) Tool Kit 4: Increase Acetylcholine & Attention/Learning; Choline-rich Foods (01:37:29) Acetylcholine Supplements: Nicotine, Alpha GPC, Huperzine   (01:44:47) Tool Kit 5: Behavior to Increase Focus & Acetylcholine (01:46:56) Tool Kit 6: Behavior to Increase Serotonin & Feelings of Well-being   (01:50:51) Tools: Tryptophan-Rich Foods & Serotonin (01:53:31) Tools: Serotonin Supplements: Cissus Quadrangularis, 5-HTP, Myo-inositol (02:02:14) Use the Neurochemical Toolkit to Meet Individual Goals (02:06:44) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Your thyroid needs these 3 vitamins in order to create thyroid hormone. If you have a deficiency in ANY of these nutrients then your body will not be able to produce thyroid hormone and you may feel the symptoms of low thyroid. The good news is that you can take this information and use it to potentially help you feel better if you have low levels of any of these nutrients. The 3 main vitamins needed to create thyroid hormone include: #1. Tyrosine. Tyrosine is a protein or amino acid and it is REQUIRED to produce thyroid hormone. This is because tyrosine forms the backbone of thyroid hormone. If you don't have enough tyrosine in your body then you won't be able to put thyroid hormone together. In addition, tyrosine also combines with itself to create something called thyroglobulin. Thyroglobulin helps to smash two half of thyroid hormone together in order to complete the finished thyroid hormone. Tyrosine can become depleted because it is also used as a building block for other hormones including epinephrine and norepinephrine in your adrenals. If you feel you are low on tyrosine then supplementing with 150mg to 500mg per day is optimal. #2. Iodine. Next up is iodine! If tyrosine forms the backbone of thyroid hormone then iodine forms the arms. You can't make thyroid hormone without iodine and MANY thyroid patients are deficient in iodine. This is because many thyroid patients have an irrational fear of iodine and avoid it at all costs. Avoiding iodine may create a low thyroid state and cause hypothyroid symptoms. You can get iodine from food or supplements and the dose should be around 150 to 300mcg per day. #3. Iron. Lastly, we have iron. Iron is important because it is required for a protein called thyroid peroxidase. Thyroid peroxidase helps your body produce thyroid hormone by interacting with thyroglobulin. Put simply, if you don't have enough iron then this enzyme won't work well and you won't be able to PRODUCE thyroid hormone even if you have enough tyrosine and enough iodine. In addition, low thyroid function reduces iron absorption which causes low iron! Low iron then causes less thyroid hormone production which causes less iron absorption and so on. Download my free thyroid resources here (including hypothyroid symptoms checklist, the complete list of thyroid lab tests + optimal ranges, foods you should avoid if you have thyroid disease, and more): https://www.restartmed.com/start-here/ Disclaimer: Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/what-happe... This video is for general informational, educational, and entertainment purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Childs and you. You should not make any changes to your medications or health regimens without first consulting a physician. If you have any questions please consult with your current primary care provider. Restart Medical LLC and Dr. Westin Childs are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video. #thyroid #hypothyroidism #hashimoto's

Today we're joined by Shelly Jo Whalstrom for Part 3 of our amino acids series! I'll link parts one & two below! Shelly Jo became a Hypnotherapist & Coach after years of struggling with sugar addiction, hoarding, and yo-yo dieting she found relief through these tools. As a mother, she went to the depths of Hell and back fighting for her daughter's life against addiction. She discovered how to help her daughter survive and thrive in a sober life. Now, she is passionate about helping others find the joy she and her family experience. Parts 1 & 2 of the series:https://podcasts.apple.com/us/podcast/coffee-and-tea-with-carrievee/id1514671446?i=1000545633092https://podcasts.apple.com/us/podcast/amino-acids-with-shelly-jo-whalstrom-part-2-gaba-chill/id1514671446?i=1000563502478Contact Shelly!www.hypnoaminos.comFeed Your Brain, Change Your Life Bookhttps://www.amazon.com/dp/1736217607/ref=as_sl_pc_as_ss_li_til?tag=bellavita12-20&linkCode=w00&linkId=d37dea3df0e2e86c71d1a522d9ede2e0&creativeASIN=1736217607Better Business Builder: https://www.kayla-ybanez.com/better-business-builderRadical Empowerment Method Book on Amazon: https://amzn.to/3Bdp2BCContact CarrieVee!IG: @iamcarrieveeLI and FB: Carrie Verrocchioemail: carriev@coachcarriev.com

Today we're joined by Shelly Jo Wahlstrom for Part 3 of our amino acids series! I'll link parts one & two below! Shelly Jo became a Hypnotherapist & Coach after years of struggling with sugar addiction, hoarding, and yo-yo dieting she found relief through these tools. As a mother, she went to the depths of Hell and back fighting for her daughter's life against addiction. She discovered how to help her daughter survive and thrive in a sober life. Now, she is passionate about helping others find the joy she and her family experience. Parts 1 & 2 of the series:https://podcasts.apple.com/us/podcast/coffee-and-tea-with-carrievee/id1514671446?i=1000545633092https://podcasts.apple.com/us/podcast/amino-acids-with-shelly-jo-whalstrom-part-2-gaba-chill/id1514671446?i=1000563502478Contact Shelly!www.hypnoaminos.comFeed Your Brain, Change Your Life Bookhttps://www.amazon.com/dp/1736217607/ref=as_sl_pc_as_ss_li_til?tag=bellavita12-20&linkCode=w00&linkId=d37dea3df0e2e86c71d1a522d9ede2e0&creativeASIN=1736217607Better Business Builder: https://www.kayla-ybanez.com/better-business-builderRadical Empowerment Method Book on Amazon: https://amzn.to/3Bdp2BCContact CarrieVee!IG: @iamcarrieveeLI and FB: Carrie Verrocchioemail: carriev@coachcarriev.com

In this episode, Dr Amanda Potter will share some insights into the Psychology and Neuroscience of habits and will look at simple 5 step approach for identifying and embedding healthy habits. Amanda will also look at the importance of healthy habits for managing stress and the role of Physical Intelligence in helping to make the habits unconditional or context independent.  In this episode, Amanda is being interviewed by Tim Hepworth. The Chief Psychology Officer website is now available https://www.thecpo.co.uk/To contact Amanda via LinkedIn: linkedin.com/in/amandapotterzirconTo contact Amanda via email: TheCPO@zircon-mc.co.ukTimestamps Healthy Habits 00:00 – Introduction to Healthy Habits 00:31 – Personal importance of this Podcast 01:39 – What defines a Habit? 01:57 – Most of what we do are Habits 02:23 – More than 85% of our time is habitual; requires minimal effort This Podcast is starting to become a Habit… 02:59 – How do Habits come about? 03:18 – Unconscious & Unaware 03:45 – Context Independent 04:04 – Is it difficult to make new Habits? 04:31 – It has to be intentional 04:44 – 5 simple steps 05:08 – Neuroscience; we love it 05:23 – Habits are basically learning 05:48 – Limbic Friction 06:07 – Fighting with ourselves 06:39 – Autonomic Nervous System 06:57 – Should I, or shouldn't I 07:36 – Neural circuitry and our own programming language It's all Chemical 08:10 – Getting through the day 08:31 – Dopamine 08:57 – How much does it cost? 09:11 – Tyrosine 09:30 – Workplace Habits 10:25 – Achieve a Goal 10:39 – Identity based Habit 11:06 – Walking the dog is a start 11:30 – Lynch Pin Habit 12:11 – Good vs. Bad Habits 13:12 – It comes from a good place… 13:48 – Reference to Burnout 14:46 – Balance in your life 15:04 – Strength of whether something is a Habit or not 15:52 – Context Independence II 16:10 – Tips on creating Healthy Habits 17:05 – Visualization 17:15 – Procedural Memory 18:39 – Micro-habits 19:19 – 5-6 Mini-Habits Gotta love the science; It's the start of something new… 20:43 – Starting your day 20:50 – Epinephrin, Dopamine & Cortisol 21:13 – Alert, not Anxious 21:39 – Refer back to Dopamine foods 22:17 – The Importance of Sleep; zzz 22:39 – A good nights sleep for the next day 23:14 – 21 Days 24:09 – The key to creating a habit; 21 Days 25:01 – The start of a promising experiment The Habits we want, and how they change us 25:32 – Tiny Habits by B.J. Fogg 25:49 – Habits you want, not what you should have 26:07 – Lower the bar… 26:39 – When do we practice new behaviours? 27:16 – Do I reward myself? 27:44 – New Habits = changed person 28:14 – Reflect on what we have achieved 29:02 – Save the Planet 29:47 – Reviewing our success, rewarding ourselves & changing our beliefs 30:37 – Last Tip for the day 30:59 – Do I want to do it? Can I do it? & what action will produce the greatest impact? 31:36 – The end. 

Ce mois-ci, Isabelle Rigaud consacre ses épisodes au sujet de la lumière : quels sont les bienfaits de la lumière ? Comment nourrir notre lumière intérieure ? En médecine chinoise, avril est la période où nos projets se concrétisent. Faire le plein d'énergie est nécessaire pour amorcer le début de l'été ! Entre exercices pratiques, conseils bien-être et nutritionnels, Isabelle Rigaud vous accompagne pour nourrir votre lumière. Retrouver la motivation avec la tyrosine Vous vous sentez un peu stressé-es ? Faites un tour du côté de la tyrosine ! Cet acide aminé compose les protéines et est constitutif des cellules de notre corps. Elle contribue au bon fonctionnement du système nerveux, à l'équilibre général et favorise l'entrain et la motivation. Mais alors, dans quels aliments la trouver ? Comment agit concrètement la tyrosine dans notre corps ? Ecoutez ses conseils nutrition dans cet épisode de Be Lively. Tous les épisodes de Be Lively sont à retrouver ici. Learn more about your ad choices. Visit megaphone.fm/adchoices

https://www.worldsbest.rehab/increase-dopamine-naturally/ https://www.worldsbest.rehab/es/increase-dopamine-naturally/ https://www.worldsbest.rehab/de/increase-dopamine-naturally/ How does dopamine work?  Most naturally produced dopamine is created in your midbrain. From there, it is distributed to different parts of the brain. The medical word is still unsure just how dopamine works in the brain. Dopamine has four major pathways inside the brain. Each pathway controls a different bodily process. Three of the pathways are reward pathways in the body.  Low dopamine levels are caused by a variety of aspects. You may suffer from low dopamine due to: Medical conditions like schizophrenia, Parkinson's disease, depression, and bipolar disorder Substance abuse Poor diet with inadequate nutrients for brain health Certain medications like antidepressants and antipsychotic drugs can stop the production of dopamine Increasing your dopamine naturally Dopamine reinforces your desire to do activities that create a sensation of pleasure. This can be positive and negative. You can have too much dopamine. Too much of the chemical slows your brain's production of dopamine. You may also build up a tolerance to dopamine. This is why addiction gets worse. You grow a tolerance to dopamine; therefore, you must increase the dose of your drug or alcohol of choice.  You can naturally increase your dopamine levels by participating in activities. These activities give you the chance to build up your dopamine levels and improve well-being. So, how do you increase your dopamine levels naturally? Have a healthy diet  A healthy diet can increase your dopamine levels. Foods like almonds, eggs, fish, and chicken contain tyrosine and are excellent for increasing your dopamine. Tyrosine is an amino acid that occurs naturally in the body. Dopamine is created using tyrosine and it is found in foods rich with protein.  Yogurt and kefir can increase the production of dopamine. Coffee can also boost your dopamine, but levels drop after consuming it. Drinks such as coffee can create caffeine addiction.  Sleep An inadequate amount of sleep can cause your dopamine levels to drop. It is important to get enough sleep each night to be healthy. On average, adults should get seven hours or more each night. If you don't get enough sleep at night, your dopamine receptors could be affected. Sleep deprivation may cause dopamine receptors to be suppressed.  Exercise Regular exercise doesn't just improve your body, but it improves your mental health. Exercising on a regular basis increases dopamine levels. Dopamine levels increase when you do exercise. After working out, many people feel a “high”. This may be due to increased dopamine levels.  Listen to music Music has the ability to improve your motivation. By listening to your favorite songs, you can improve your dopamine levels. Research found that listening to your favorite songs may lead to a release of dopamine in the brain.  Mindfulness and meditation Mindfulness and meditation are tools that have been used for centuries. Both have a significant impact on mental health. Meditation has been found to increase dopamine levels.  Reduce processed sugar Soda and candy contain processed sugar. Processed sugar has the ability to improve your dopamine levels, but these increases are temporary. In addition, the increase is artificial. Consuming processed sugar may make you feel great quickly, but you will crash following the sudden elation. Once you come down, you will likely feel down.  By cutting out processed sugars, your body won't experience artificial dopamine increases. Therefore, you won't experience crashes after the sugar high wears off. In addition, you won't become addicted to sugar.  Eliminate stress Stress may cause a decrease in dopamine levels. If you can control or eliminate the amount of stress in your life, you can improve your dopamine levels. There are activities you can participate in to reduce the amount of stress in your life. Activities such as meditation and exercise can reduce the stress you experience.  Get some sun A lack of sunlight can lead to poor mental health and low mood. You may even experience Seasonal Affective Disorder (SAD), which is a condition that affects an estimated 10 million men and women in America.  Just 20 minutes of sunlight per day on your skin can improve your mental health. By getting sunlight in the morning or late afternoon, you can greatly improve your mental health courtesy of increased dopamine levels.  You can increase dopamine levels naturally by making a few changes to your day. Altering your day and adding these healthy routines can be the difference you need to increase dopamine levels.  https://www.worldsbest.rehab/  

Whether you're new to the gym, an everyday athlete, or a pro at lifting weights, chances are you have heard of, tried, or religiously take pre-workout. With a forever-growing list of pre-workout formulas, how do you choose the best one for you and your fitness goals? In today's episode of the ATP project, Jeff and Steve get nitty-gritty talking about the science behind the best pre-workout ingredients and which ones you should look for depending on your goals.  The team discusses the categories and functions of pre-workouts if becoming desensitised to caffeine is really a myth, as well as the reasons as to why Saffron, Carnitine, Beta-alanine, Acetylcholine, Tyrosine, Alpha GPC, and Huperzine-A may be beneficial in a pre-workout. Whether you're looking for a pump, increased performance, more muscle strength, or focus, this episode will be for you As always, this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only - please discuss any information in this podcast with your health care professional before making any changes to your current lifestyle.   Check out ATP Science's range of products at our online store - https://bit.ly/3vIDr9z

The microbiome is the plethora of additional organisms in our bodies that perform an array of positive functions for our health. Tom takes his first look at what the microbiome is, the function and importance of good gut health, how we can maintain a healthy microbiome, and the many advantages this can offer us. KEY TAKEAWAYS Studies have shown that a healthy microbiome can result in weight loss and reduced waist size, healthier skin and less wrinkles, reduced inflammation and joint pain, faster recovery from exertion, improved sleep, increased strength and muscle mass, better bone health and density, less anxiety and better moods, improved immune response and faster healing. There are approximately 3 trillion individual microbiota (the bacteria, viruses, parasites, fungi that live on our skin and also within our bodies). A healthy microbiome is not due to sheer number of microbiota, however, but rather to do with the diversity of different species. Eat a diet including a wide variety of vegetables, pulses and fruits that are high in fibre. The less processed the better. The gut needs a healthy amount of tryptophan, found in food like turkey, eggs and chia seeds as it helps the production of serotonin and melatonin. Tyrosine helps to produce dopamine and epinephrine (adrenaline) and can be found in almonds, lentils and seeds. Increase the amount of fermented food in your diet. These act as a probiotic (‘fertiliser’) for your microbiome. Fermented teas and vegetables, kefir, and yoghurt with live cultures are good sources. Probiotics can also be acquired through pills and sachets, but look out for Bifido Bacteria Infantis (for babies and new mothers especially) and Lactobacillus Reuteri, as specialists recommend these two particularly. BEST MOMENTS ‘We are now able to make links with microbiome irregularities and different autoimmune conditions, diabetes, Alzheimer’s, rosacea (which is a type of reddening of the skin), anxiety and depression. And it's not just about improving health and reducing the risk of illness.’ ‘Leading experts believe that in the coming years scientific research will find that in order to be the most effective at protecting us, the microbiome will work in teams, or as a collective to assist each other or help each other out.’ ‘A lack of tyrosine can adversely affect our motivation and also dampen the fight or flight response.’ ‘What happens when we restore it (Lactobacillus Reuteri)? We get increased production of oxytocin, which is a real feel-good chemical that’s often known as, and this is a great name, the ‘hormone of love and empathy’’ VALUABLE RESOURCES https://youtube.com/channel/UCQXAka99a6MdZexeEJaMZbAhttps://m.facebook.com/elevatehealthuk/https://www.elevatehealthuk.com/https://instagram.com/elevate_healthuk?utm_medium=copy_link ABOUT THE HOST TOM BUTTERFIELD I have always been interested in sports, unfortunately injuries and poor training decisions curtailed my dream of becoming a professional football player. I have always been very passionate about helping people and I get a real kick out of seeing people improve and...

My AP Biology Thoughts  Unit 4 Cell Communication and Cell CycleWelcome to My AP Biology Thoughts podcast, my name is Sid and I am your host for episode #86 called Unit 4 Cell Communication and Cell Cycle: G Protein Receptors and Tyrosine Kinase Receptors. Segment 1: Introduction to G protein receptors and tyrosine kinase receptors G Protein receptors and tyrosine kinase receptors both work to mediate cell communication by binding a signaling molecule, which is also called a ligand. Then this signal is sent through a transduction pathway where the last target protein causes some response. The response for both can be a variety of things such as gene expression, apoptosis, metabolic responses, cell division, or cell growth. Despite being similar in this way, g protein receptors and tyrosine kinase receptors work in very different ways Segment 2: More About G protein receptors Let's start by discussing g protein receptors. G proteins are very diverse and can bind to many different signals. One example is odorant (or scent) receptors. G proteins receptors are located in the cell membrane which is where an extracellular ligand binds to it. The signal is eventually sent to a g protein which is located on the membrane, but on the cytoplasmic side. Before the G protein is activated, GDP is bound to it which keeps it inactive. GDP is guanosine diphosphate. After the signal binds to the receptor, the receptor slightly changes shape and becomes active. Then, the GDP binds to the g protein receptor. Since the G protein no longer has a GDP bound to it, it frees it up to accept and bind to GTP. The GTP activates the G protein. The G protein is made up of three subunits: alpha, beta, and gamma. When the GTP is bound to the G protein and activates it, the alpha subunit detaches and moves away from the receptor. Now the G protein is split into two parts: one part is the single alpha subunit and the other is the beta and gamma subunits. These two parts can go on to interact with other proteins and cause a transduction pathway that results in one of many responses. Eventually, the alpha subunit comes back and hydrolyzes the GTP which keeps the G protein active and changes it back into GDP. At this point the G protein will once again become inactive. G proteins coupled receptors are very important in the human body. Disruptions can cause diseases like cystic fibrosis or cholera.  Now let's talk about tyrosine kinase receptors. Tyrosine kinase receptors are enzyme linked receptors. Enzyme linked receptors are receptors that are associated with an enzyme. A kinase is a protein that phosphorylates other proteins. For tyrosine kinase receptors, the kinase phosphorylates tyrosine. To start the process, a signalling molecule attaches to two tyrosine kinase receptors. These come together and form a dimer. Then, each tyrosine kinase receptor phosphorylates the domains of the tyrosine kinase receptor. Then, once the tyrosine is phosphorylated, it can send signals to other molecules Segment 3: Connection to the Course G protein receptors and tyrosine kinase receptors are very important to many species. Problems with g protein receptors can cause choler, cystic fibrosis, and some bacterial infections. Problems with tyrosine kinase receptors can also cause diseases and cancers. Both of these receptors play integral parts in many different species. This can be evidence of the endosymbiotic theory. Since so many species use these receptors, they likely came from a common ancestor and had an evolutionary advantage. Thank you for listening to this episode of My AP Biology Thoughts. For more student-ran podcasts and digital content, make sure that you visit http://www.hvspn.com (www.hvspn.com).  Music Credits: "Ice Flow" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/ Subscribe to our Podcast...

Summary - Acetylcholine is not often talked about but is a necessary excitatory neurotransmitter - Acetylcholine interacts with gonadal hormones, thyroid hormones and several neurotransmitters - Acetylcholine is important for energy, memory, attention, regulation of muscle contraction and much more. - Choline is necessary to make acetylcholine - Tyrosine is necessary to make acetylcholine - Too much acetylcholine contributes to anxiety and irritability, too little contributes to anhedonia Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to The Nutritional Pearls Podcast! Focusing on topics that include digestion, adrenal fatigue, leaky gut, supplementation, electrolytes, stomach acid, and so much more, “The Nutritional Pearls Podcast” features Christine Moore, NTP and is hosted by Jimmy Moore, host of the longest running nutritional podcast on the Internet.  Sharing nuggets of wisdom from Christine's training as a Nutritional Therapy Practitioner and Jimmy's years of podcasting and authoring international bestselling health and nutrition books, they will feature a new topic of interest and fascination in the world of nutritional health each Monday. Listen in today as Christine and Jimmy talk all about protein in Episode 8. Here's what Christine and Jimmy talked about in Episode 8: 1. Review of Nutrient Classes: A. Water B. Macronutrients 1. Proteins=18% of the body 2. Fats=15% of the body 3. Carbohydrates=2% of the body C. Micronutrients 1. Minerals=4% of the body 2. Vitamins=1% of the body 2. Facts about proteins A. They make up about 18% of the body B. They are the building blocks of our body C. The human body uses about 50,000 different proteins to form 4 different things: 1. Nerves 2. Muscles 3. Organs 4. Flesh D. Some proteins have specialized functions like 1. Enzymes which help with all biochemical processes 2. Some proteins are antibodies. Antibodies help to fight infection and destroy foreign invaders that get into the body. E. Proteins are essential for normal growth. F. The help form hormones which help with regulation of metabolism and plays a role in just about every important function of the body. G. Some are hemoglobin. Hemoglobin contains red bloods cells which help deliver oxygen throughout the body. H. Proteins are needed for the blood to clot. I. Proteins even help control the pH of the tissues and blood J. Animal proteins are our only source of COMPLETE proteins. Proteins from animals contain all of the essential amino acids needed PLUS many that are nonessential, meaning the body can make those. Vegetables only contain incomplete proteins, meaning they do not have all the essential proteins our bodies need. The 2 best sources of vegetable proteins are legumes and cereal grains, neither of which we consume on a ketogenic diet. K. Proteins cannot be properly utilized without sources of animal fat. This is why you see protein AND fat in eggs, milk, fish, and meats. L. Our ancestors ate mostly meat (nose to tail) and SUPPLEMENTED their diets with vegetables, fruits, nuts, and seeds. 1. Our best source of zinc is from animal products 2. Usable vitamin B12 only occurs in animal products M. A high protein, low fat diet can cause problems 1. Causes too rapid of growth 2. Causes depletion of vitamin A and vitamin D and some minerals, too. N. Red meat contains cysteine which is essential for a healthy immune system. O. The sulfur-containing amino acid cysteine is also needed for making glutathione, which is a powerful antioxidant that helps prevent cell damage. P. Those 50,000 proteins combine to make 22 different amino acids and the amino acids are broken down into 4 different classes of amino acids 1. 10 Essential-the body can't make these so we have to get them from outside sources. 2. 10 Nonessential-the body can make these. 3. 7 Conditional-the body can usually make these under normal circumstances, but a sickness or stress might cause the body to not be able to make them. 4. 2 Nonstandard-these are not found in the human body but in a gutless marine worm List of Amino Acids 1. Essential Amino Acids 2. Nonessential Amino Acids 3. Other Amino Acids A. Isoleucine A. Alanine A. Carnitine B. Leucine B. Asparagine B. Citrulline C. Lysine C. Aspartic Acid C. Gamma-aminobutyric acid D. Methionine D. Cysteine D. Glutathione E. Phenylalanine E. Glutamine E. Ornithine F. Threonine F. Glutamic Acid F. Taurine G. Tryptophan G. Glycine G. Cystine H. Valine H. Proline I. Histidine I. Serine J. Arginine J. Tyrosine-thyroid function Q. Roles of amino acids 1. Forming proteins 2. Helping with neurotransmitter production 3. Muscle production 4. Hormone production 5. RNA and DNA regulation. 3. Sources Of Protein 1. Fish and seafood that is wild caught. These should be mainly smaller fish to help prevent exposure to heavy metals 2. Beef, lamb, buffalo, elk, goat, and more that is organic and 100% grass fed and grass finished 3. Poultry like chicken, turkey, and duck that is also organic and 100% pasture raised, and eggs 4. Dairy products from animals that are 100% pasture raised and organic. These include full fat cheeses, full fat cottage cheese, full fat raw milk and cream, full fat yogurt and full fat, grass fed butter. 5. Nuts and seeds like pumpkin seeds, sunflower seeds, almonds, pecans, macadamia nuts, pili nuts, and pistachio nuts that have been soaked and sprouted Note: These Amino Acids are not used as building blocks within the body but are still important. 4. Nonstandard Amino Acids (Not found in the human body) A. Selenocysteine-discovered in 1986 B. Pyrrolysine-discovered in 2002 (found in a gutless marine worm) Nutritional Pearl for Episode 8: Protein is essential in the right kind and the proper amounts. YOUR NEW KETO DIET ALLY NOTICE OF DISCLOSURE: Paid sponsorship BECOME A NUTRITIONAL THERAPY PRACTITIONER Sign up for the 9-month program NOTICE OF DISCLOSURE: Paid sponsorship GET A $39 BOTTLE OF OLIVE OIL FOR JUST A BUCK GET YOUR $39 BOTTLE FOR JUST $1 NOTICE OF DISCLOSURE: Paid sponsorship   LINKS MENTIONED IN EPISODE 8 – SUPPORT OUR SPONSOR: Complete nutriton for nutritional ketosis (COUPON CODE LLVLC FOR 10% OFF YOUR FIRST ORDER) – SUPPORT OUR SPONSOR: Become A Nutritional Therapy Practitioner – SUPPORT OUR SPONSOR: The world's freshest and most flavorful artisanal olive oils. Get your $39 bottle for just $1 – JIMMY'S KETO LIVING SUPPLEMENT LINE: Try the KetoEssentials Multivitamin and Berberine Plus ketogenic-enhancing supplements