Podcasts about GMP

Dr. John Sweetenham and Dr. Erika Hamilton highlight key abstracts that were presented at ASCO25, including advances in breast and pancreatic cancers as well as remarkable data from the use of structured exercise programs in cancer care. Transcript Dr. Sweetenham: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. John Sweetenham. Today, we'll be discussing some of the key advances and novel approaches in cancer care that were presented at the 2025 ASCO Annual Meeting. I'm delighted to be joined again by the chair of the Meeting's Scientific Program, Dr. Erika Hamilton. She is a medical oncologist and director of breast cancer and gynecologic cancer research at the Sarah Cannon Research Institute in Nashville, Tennessee.  Our full disclosures are available in the transcript of this episode. Dr. Hamilton, congratulations on a fantastic meeting. From the practice-changing science to the world-renowned speakers at this year's Meeting, ASCO25 really reflected the amazing progress we're seeing in oncology today and the enormous opportunities that lie ahead of us. And thanks for coming back on to the podcast today to discuss some of these advances. Dr. Hamilton: Thanks, Dr. Sweetenham. I'm happy to join you today. It really was an impactful ASCO Annual Meeting. I probably am biased, but some great research was presented this year, and I heard lots of great conversations happening while we were there. Dr. Sweetenham: Yeah, absolutely. There was a lot of buzz, as well as a lot of media buzz around the meeting this year, and I think that's probably a good place to start. So I'd like to dive into abstract number LBA3510. This was the CHALLENGE trial, which created a lot of buzz at the meeting and subsequently in the media. This is the study that was led by the NCI Canada Clinical Trials Group, which was the first randomized phase 3 trial in patients with stage III and high-risk stage II colon cancer, which demonstrated that a post-treatment structured exercise program is both feasible and effective in improving disease-free survival in this patient group. The study was performed over a long period of time and in many respects is quite remarkable. So, I wonder if you could give us your thoughts about this study and whether you think that this means that our futures are going to be full of structured exercise programs for those patients who may benefit. Dr. Hamilton: It's a fantastic question. I think that this abstract did create a lot of buzz. We were very excited when we read it. It was highlighted in one of the Clinical Science Symposium sessions. But briefly, this was a phase 3 randomized trial. It was conducted at 55 centers, so really a broad experience, and patients that had resected colon cancer who completed adjuvant therapy were allowed to participate. There were essentially 2 groups: a structured exercise program, called ‘the exercise group,' or health education materials alone, so that was called just ‘the health education group.' And this was a 3-year intervention, so very high quality. The primary end point, as you mentioned, was disease-free survival. This actually accrued from 2009 to 2024, so quite a lift, and almost 900 patients underwent randomization to the exercise group or the health education group. And at almost 8 years of follow-up, we saw that the disease-free survival was significantly longer in the exercise group than the health education group. This was essentially 80.3% of patients were disease-free in exercise and 73.9% in the health education group. So a difference of over 6 percentage points, which, you know, at least in the breast cancer world, we make decisions about whether to do chemotherapy or not based on these kind of data. We also looked at overall survival in the exercise group and health education group, and the 8-year overall survival was 90.3% in the exercise group and 83.2% in the health education group. So this was a difference of 7.1%. Still statistically significant. I think this was really a fantastic effort over more than a decade at over 50 institutions with almost 900 patients, really done in a very systematic, high-intervention way that showed a fantastic result. Absolutely generalizable for patients with colon cancer. We have hints in other cancers that this is beneficial, and frankly, for our patients for other comorbidities, such as cardiovascular, etc., I really think that this is an abstract that deserved the press that it received. Dr. Sweetenham: Yeah, absolutely, and it is going to be very interesting, I think, over the next 2 or 3 years to see how much impact this particular study might have on programs across the country and across the world actually, in terms of what they do in this kind of adjuvant setting for structured exercise. Dr. Hamilton: Absolutely.  So let's move on to Abstract 3006. This was an NCI-led effort comparing genomic testing using ctDNA and tissue from patients with less common cancers who were enrolled in but not eligible for a treatment arm of the NCI-MATCH trial. Tell us about your takeaways from this study. Dr. Sweetenham: Yeah, so I thought this was a really interesting study based, as you said, on NCI-MATCH. And many of the listeners will probably remember that the original NCI-MATCH study screened almost 6,000 patients to assess eligibility for those who had an actionable mutation. And it turned out that about 60% of the patients who went on to the study had less common tumors, which were defined as anything other than colon, rectum, breast, non–small cell lung cancer, or prostate cancer. And most of those patients lacked an eligible mutation of interest and so didn't get onto a trial therapy. But with a great deal of foresight, the study group had actually collected plasma samples from these patients so that they would have the opportunity to look at circulating tumor DNA profiles with the potential being that this might be another way for testing for clinically relevant mutations in some of these less common cancer types. So initially, they tested more than 2,000 patients, and to make a somewhat complicated story short, there was a subset of five histologies with a larger representation in terms of sample size. And these were cholangiocarcinoma, small cell lung cancer, esophageal cancer, pancreatic, and salivary gland cancer. And in those particular tumors, when they compared the ctDNA sequencing with the original tumor, there was a concordance there of around 84%, 85%. And in the presentation, the investigators go on to list the specific mutated genes that were identified in each of those tumors. But I think that the other compelling part of this study from my perspective was not just that concordance, which suggests that there's an opportunity there for the use of ctDNA instead of tumor biopsies in some of these situations, but what was also interesting was the fact that there were several clinically relevant mutations which were detected only in the circulating tumor DNA. And a couple of examples of those included IDH1 for cholangiocarcinoma, BRAF and p53 in several histologies, and microsatellite instability was most prevalent in small cell lung cancer in the ctDNA. So I think that what this demonstrates is that liquid biopsy is certainly a viable screening option for patients who are being assessed for matching for targeted therapies in clinical trials. The fact that some of these mutations were only seen in the ctDNA and not in the primary tumor specimen certainly suggests that there's some tumor heterogeneity. But I think that for me, the most compelling part of this study was the fact that many of these mutations were only picked up in the plasma. And so, as the authors concluded, they believe that a comprehensive gene profiling with circulating tumor DNA probably should be included as a primary screening modality in future trials of targeted therapy of this type. Dr. Hamilton: Yeah, I think that that's really interesting and mirrors a lot of data that we've been seeing. At least in breast cancer, you know, we still do a biopsy up front to make sure that our markers, we're still treating the right disease that we think we are. But it really speaks to the utility of using ctDNA for serial monitoring and the emergence of mutations. Dr. Sweetenham: Absolutely. And you mentioned breast cancer, and so I'd like to dwell on that for a moment here because obviously, there was a huge amount of exciting breast cancer data presented at the meeting this year. And in particular, I'd like to ask you about LBA1008, the DESTINY-Breast09 clinical trial, which I think has the potential to establish a new first-line standard of care for metastatic HER2+ breast cancer. And that's an area where we haven't seen a whole lot of innovation for around a decade now. So can you give us some of the highlights of this trial and what your thinking is, having seen the results? Dr. Hamilton: Yeah, absolutely. So this was a trial in the first-line metastatic HER2 setting. So this was looking at trastuzumab deruxtecan. We certainly have had no shortage of reports around this drug, initially approved for later lines. DESTINY-Breast03 brought it into our second-line setting for HER2+ disease and we're now looking at DESTINY-Breast09 in first-line. So this actually was a 3-arm trial where patients were randomized 1:1:1 against standard taxane/trastuzumab/pertuzumab in one arm; trastuzumab deruxtecan with pertuzumab in another arm; and then a third arm, trastuzumab deruxtecan alone. And what we did not see reported was that trastuzumab deruxtecan-alone arm. But we did have reports from the trastuzumab deruxtecan plus pertuzumab versus the chemo/trastuzumab/pertuzumab. And what we saw was a statistically significant improvement in median progression-free survival, 26.9 months up to 40.7, so an improvement of 13.8 months, over a year in PFS. Not to mention that we're now in the 40-month range for PFS in first-line disease. Really, across all subgroups, we really weren't able to pick out a subset of patients that did not benefit. We did see about a 12% ILD rate with trastuzumab deruxtecan. That really is on par with what we've seen in other studies, around 10%-15%. I think that this is going to become a new standard of care in the first-line. I think it did leave some unanswered questions. We saw some data from the PATINA trial this past San Antonio Breast, looking at the addition of endocrine therapy with or without a CDK4/6 inhibitor, palbociclib, for those patients that also have ER+ disease, after taxane has dropped out in the first-line setting. So how we're going to kind of merge all this together is, I suspect that there are going to be patients that we or they just don't have the appetite to continue 3 to 4 years of trastuzumab deruxtecan. And so we're probably going to be looking at a maintenance-type strategy for them, maybe integrating the PATINA data there. But how we really put this into practice in the first-line setting and if or when we think about de-escalating down from trastuzumab deruxtecan to antibody therapy are some lingering questions. Dr. Sweetenham: Okay, so certainly is going to influence practice, but watch this space for a little bit longer, it sounds as though that's what you're saying. Dr. Hamilton: Absolutely.  So let's move on to GI cancer. Abstract 4006 reported preliminary results from the randomized phase 2 study of elraglusib in combination with gemcitabine/nab-paclitaxel versus the chemo gemcitabine/nab-paclitaxel alone in patients with previously untreated metastatic pancreatic cancer. Can you tell us more about this study? Dr. Sweetenham: Yeah, absolutely. As you mentioned, elraglusib is actually a first-in-class inhibitor of GSK3-beta, which has multiple potential actions in pancreatic cancer. But the drug itself may be involved in mediating drug resistance as well as in some tumor immune response modulation. Some of that's not clearly understood, I believe, right now. But certainly, preclinical data suggests that the drug may be effective in preclinical models and may also be effective in combination with chemotherapy and potentially with immune-modulating agents as well. So this particular study, as you said, was an open-label, randomized phase 2 study in which patients with pancreatic cancer were randomized 2:1 in favor of the elraglusib plus GMP—gemcitabine and nab-paclitaxel—versus the chemotherapy alone. And upon completion of the study, which is not right now, median overall survival was the primary end point, but there are a number of other end points which I'll talk about in just a moment. But the sample size was planned to be around 207 patients. The primary analysis included 155 patients in the combination arm versus 78 patients in the gemcitabine/nab-paclitaxel arm. Overall, the 1-year overall survival rate was 44.1% for the patients in the elraglusib-containing arm versus 23.0% in the patients receiving gemcitabine/nab-paclitaxel only. When they look at the median overall survival, it was 9.3 months for the experimental arm versus 7.2 months for chemotherapy alone. So put another way, there's around a 37% reduction in the risk of death with the use of this combination arm. The treatment was overall well-tolerated. There were some issues with grade 1 to 2 transient visual impairment in a large proportion of the patients. The most common treatment-related adverse effects with the elraglusib/GMP combination was transient visual impairment, which affected around 60% of the patients. Most of the more serious treatment-related adverse events included neutropenia, anemia, and fatigue in 50%, 25%, and 16% of the patients, respectively. So the early results from this study show a significant benefit for 1-year overall survival and for median overall survival with, as I mentioned above, a significant reduction in the risk of death. The authors went on to mention that the median overall survival for the control arm in this study is somewhat lower than in other comparable trials, but they think that this may be related to a more advanced disease burden in this particular study. Of interest to me was that right now: there is no apparent difference in progression-free survival between the 2 arms of this study. The authors described this as potentially indicating that this may be related in some way to immune modulation and immune effects on the tumor, which, if I'm completely honest, I don't totally understand. And so, the improvement in overall survival, as far as I can see at the moment, is not matched by an improvement in progression-free survival. So I think we probably need to wait for more time to elapse to see what happens with the study. And so, I think it certainly is an interesting study, and the results are intriguing, but I think it's probably a little early for it to actually shift the treatment paradigm in this disease. Dr. Hamilton: Fantastic. I think we've been waiting for advances in pancreatic cancer for a long time, but this, not unlike others, we learn more and then learn more we don't realize, so. Dr. Sweetenham: Right. Let's shift gears at this point and talk about a couple of other abstracts in kind of a very different space. Let's start out with symptom management for older adults with cancer. We know that undertreated symptoms are common among the older patient population, and Abstract 11002 reported on a randomized trial that demonstrated the effects of remote monitoring for older patients with cancer in terms of kind of symptoms and so on. Can you tell us a little bit about this study and whether you think this approach will potentially improve care for older patients? Dr. Hamilton: Yeah, I really liked this abstract. It was conducted through the Veterans Affairs, and it was based in California, which I'm telling you that because it's going to have a little bit of an implication later on. But essentially, adults that were 75 years or older who were Medicare Advantage beneficiaries were eligible to participate. Forty-three clinics in Southern California and Arizona, and patients were randomized either into a control group of usual clinic care alone, or an intervention group, which was usual care plus a lay health worker-led proactive telephone-based weekly symptom assessment, and this was for 12 months using the validated Edmonton Symptom Assessment System. So, there was a planned enrollment of at least 200 patients in each group. They successfully met that. And this lay health worker reviewed assessments with a physician assistant, who conducted follow-up for symptoms that changed by 2 points from a prior assessment or were rated 4 or greater. So almost a triage system to figure out who needed to be reached out to and to kind of work on symptoms. What I thought was fantastic about this was it was very representative of where it enrolled. There were actually about 50% of patients enrolled here that were Hispanic or Latinos. So some of our underserved populations and really across a wide variety of tumor types. They found that the intervention group had 53% lower odds of emergency room use, 68% lower odds of hospital use than the control group. And when they translated this to actual total cost of care, this was a savings of about $12,000 U.S. per participant and 75% lower odds of a death in an acute care facility. So I thought this was really interesting for a variety of reasons. One, certainly health care utilization and cost, but even more so, I think any of our patients would want to prevent hospitalizations and ER visits. Normally, that's not a fantastic experience having to feel poorly enough that you're in the emergency room or the hospital. And really showing in kind of concrete metrics that we were able to decrease this with this intervention. In terms of sustainability and scalability, I think the question is really the workforce to do this. Obviously, you know, this is going to take dedicated employees to have the ability to reach out to these patients, etc., but I think in value-based care, there's definitely a possibility of having reimbursement and having the funds to institute a program like this. So, definitely thought-provoking, and I hope it leads to more interventions. Dr. Sweetenham: Yeah, we've seen, over several years now, many of these studies which have looked at remote symptom monitoring and so on in this patient population, and many of them do show benefits for that in kinds of end points, not the least in this study being hospitalization and emergency room avoidance. But I think the scalability and personnel issue is a huge one, and I do wonder at some level whether we may see some AI-based platforms coming along that could actually help with this and provide interactions with these patients outside of actual real people, or at least in combination with real people. Dr. Hamilton: Yeah, that's a fantastic point.  So let's talk a little bit about clinical trials. So eligibility assessment for oncology clinical trials, or prescreening, really relies on manual review of unstructured clinical notes. It's time-consuming, it's prone to errors, and Abstract 1508 reported on the final analysis of a randomized trial that looked at the effect of human-AI teams prescreening for clinical trial eligibility versus human-only or AI-only prescreening. So give us more good news about AI. What did the study find? Dr. Sweetenham: Yeah, this is a really, a really interesting study. And of course, any of us who have ever been involved in clinical trials will know that accrual is always a problem. And I think most centers have attempted, and some quite successfully managed to develop prescreening programs so that patients are screened by a health care provider or health care worker prior to being seen in the clinic, and the clinical investigator will then already know whether they're going to be eligible for a trial or not. But as you've already said, it's a slow process. It's typically somewhat inefficient and requires a lot of time on the part of the health care workers to actually do this in a successful way. And so, this was a study from Emory University where they took three models of ways in which they could assess the accuracy of the prescreening of charts for patients who are going to be considered for clinical trials. One of these was essentially the regular way of having two research coordinators physically abstract the charts. The second one was an AI platform which would extract longitudinal EHR data. And then the third one was a combination of the two. So the AI would be augmented by the research coordinator or the other way around. As a gold standard, they had three independent oncology reviewers who went through all of these charts to provide what they regarded as being the benchmark for accuracy. In a way, it's not a surprise to me because I think that a number of other systems which have used this combination of human verification of AI-based tools, it actually ultimately concluded that the combination of the two in terms of chart accuracy was for the most part better than either one individually, either the research coordinator or the AI alone. So I'll give you just a few examples of where specifically that mattered. The human plus AI platform was more accurate in terms of tumor staging, in terms of identifying biomarker testing and biomarker results, as well as biomarker interpretation, and was also superior in terms of listing medications. There are one or two other areas where either the AI alone was somewhat more accurate, but the significant differences were very much in favor of a combination of human + AI screening of these patient charts. So, in full disclosure, this didn't save time, but what the authors reported was that there were definite efficiency gains, and presumably this would actually become even more improved once the research coordinators were somewhat more comfortable and at home with the AI tool. So, I thought it was an interesting way of trying to enhance clinical trial accrual up front by this combination of humans and technology, and I think it's going to be interesting to see if this gets adopted at other centers in the future. Dr. Hamilton: Yeah, I think it's really fascinating, all the different places that we can be using AI, and I love the takeaway that AI and humans together are better than either individually. Dr. Sweetenham: Absolutely.  Thanks once again, Dr. Hamilton, for sharing your insights with us today and for all of the incredible work you did to build a robust program. And also, congratulations on what was, I think, a really remarkable ASCO this year, one of the most exciting for some time, I think. So thank you again for that. Dr. Hamilton: Thanks so much. It was really a pleasure to work on ASCO 2025 this year. Dr. Sweetenham: And thank you to our listeners for joining us today. You'll find links to all the abstracts we discussed today in the transcript of this episode. Be sure to catch up on all of our coverage from the Annual Meeting. You can catch up on my daily reports that were published each day of the Annual Meeting, featuring the key science and innovations presented. And we'll have wrap-up episodes publishing in June, covering the full spectrum of malignancies from ASCO25. If you value the insights you hear on the ASCO Daily News Podcast, please remember to rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   More on today's speakers: Dr. John Sweetenham   Dr. Erika Hamilton @erikahamilton9   Follow ASCO on social media:  @ASCO on Twitter  ASCO on Bluesky  ASCO on Facebook   ASCO on LinkedIn     Disclosures:     Dr. John Sweetenham:     No relationships to disclose    Dr. Erika Hamilton: Consulting or Advisory Role (Inst): Pfizer, Genentech/Roche, Lilly, Daiichi Sankyo, Mersana, AstraZeneca, Novartis, Ellipses Pharma, Olema Pharmaceuticals, Stemline Therapeutics, Tubulis, Verascity Science, Theratechnologies, Accutar Biotechnology, Entos, Fosun Pharma, Gilead Sciences, Jazz Pharmaceuticals, Medical Pharma Services, Hosun Pharma, Zentalis Pharmaceuticals, Jefferies, Tempus Labs, Arvinas, Circle Pharma, Janssen, Johnson and Johnson   Research Funding (Inst): AstraZeneca, Hutchison MediPharma, OncoMed, MedImmune, Stem CentRx, Genentech/Roche, Curis, Verastem, Zymeworks, Syndax, Lycera, Rgenix, Novartis, Millenium, TapImmune, Inc., Lilly, Pfizer, Lilly, Pfizer, Tesaro, Boehringer Ingelheim, H3 Biomedicine, Radius Health, Acerta Pharma, Macrogenics, Abbvie, Immunomedics, Fujifilm, eFFECTOR Therapeutics, Merus, Nucana, Regeneron, Leap Therapeutics, Taiho Pharmaceuticals, EMD Serono, Daiichi Sankyo, ArQule, Syros Pharmaceuticals, Clovis Oncology, CytomX Therapeutics, InventisBio, Deciphera, Sermonix Pharmaceuticals, Zenith Epigentics, Arvinas, Harpoon, Black Diamond, Orinove, Molecular Templates, Seattle Genetics, Compugen, GI Therapeutics, Karyopharm Therapeutics, Dana-Farber Cancer Hospital, Shattuck Labs, PharmaMar, Olema Pharmaceuticals, Immunogen, Plexxikon, Amgen, Akesobio Australia, ADC Therapeutics, AtlasMedx, Aravive, Ellipses Pharma, Incyte, MabSpace Biosciences, ORIC Pharmaceuticals, Pieris Pharmaceuticals, Pieris Pharmaceuticals, Pionyr, Repetoire Immune Medicines, Treadwell Therapeutics, Accutar Biotech, Artios, Bliss Biopharmaceutical, Cascadian Therapeutics, Dantari, Duality Biologics, Elucida Oncology, Infinity Pharmaceuticals, Relay Therapeutics, Tolmar, Torque, BeiGene, Context Therapeutics, K-Group Beta, Kind Pharmaceuticals, Loxo Oncology, Oncothyreon, Orum Therapeutics, Prelude Therapeutics, Profound Bio, Cullinan Oncology, Bristol-Myers Squib, Eisai, Fochon Pharmaceuticals, Gilead Sciences, Inspirna, Myriad Genetics, Silverback Therapeutics, Stemline Therapeutics

Conversation #335:  Third Quarter Conversations:  All About Supplements Welcome to The Third Quarter Conversations, a space where we dive into the meaningful, insightful, educational, and downright hilarious aspects of this incredible stage of life. Each month, we'll explore the topics that truly matter—health, relationships, personal growth, and everything in between—through candid and engaging discussions. Join us as we navigate this next phase with wisdom, laughter, and a whole lot of heart!In today's conversation, Jennifer and I discuss the wild world of supplements. We take it from a professional and personal perspective. Tips to know before supplementing, what to look for when buying supplements and current supplement stacks we are both using. Please enjoy another third quarter conversation!Connect with Jennifer on Instagram Connect with Anne on Instagram and Email“Items of note” (we do not have an partnerships or affiliations with these products)Brands:  Pure Encapsulations, Thorne, Designs for Health, Nature Made, Nordic Naturals, CardioTabs, Bee Keeper's NaturalsThird Party Certification: USP's Dietary Supplement Verification Program, NSF and GMP, Consumer LabFullscript - Supplement store

More about GMP! AI Awareness month - https://www.skool.com/gmpvip/gmps-ai-awareness-month-june-2025-what-does-it-mean-to-youFind Tom at www.tomevans.coEnjoy content from Good Morning Portugal! published every day only on YouTube, please comment, like & subscribe.For 'resources for the rest of your life in Portugal', join the Portugal Club at www.theportugalclub.com for daily news, Portuguese language and culture, classroom, courses, calendar and community. Feeling lost, stuck or in need of inspiration? Or want friendly and positive support with your Portugal dream and plans? Try Carl's new consultancy service - by phone, on the web, over lunch, or enjoying a walk with him in his beloved Sao Martinho Bay.Review, evaluate and refine your Portugal Plan with Carl - for your best possible life here...https://ko-fi.com/gmp/commissionsBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

The Good Morning Portugal! Wine Club has been trying and celebrating Portuguese wines, and other nationally-loved drinks, since 2020.On this occasion, the GMP! Wine Ninjas will share their favourite personal selections from over the last five years.Thereafter at 8.30pm, GMP!VIPs are invited to an off-line, lock-in for further savouring, love-in of Portuguese life, and inevitably putting the world to rights!Join us every first Monday of the month for the GMP! WINE CLUB and become a GMP!VIP at www.gmpvip.comEnquiries: carl@goodmorningportugal.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

In this episode of Careers in Discovery, we're joined by Markus Gruell, Senior Vice President of Corporate Quality at Autolus, one of the UK's leading CAR-T therapy pioneers. Markus takes us behind the scenes of Autolus' journey from a UCL spinout to a commercial-stage Biopharma company, offering a rare look at how quality underpins every part of the drug development lifecycle. From working across GMP and GCP to collaborating with regulators on novel therapies, Markus shares what it means to lead quality in a fast-moving, high-growth Biotech business. We also explore Markus' personal journey - from pharmacist to QP, and from the NHS to senior leadership - guided by a passion for learning, a commitment to patient safety, and a belief in empowering his team through empathy and integrity. If you're curious about CAR-T, what quality looks like in a next-gen therapy company, or how to build a meaningful leadership career without a traditional plan, this episode is not to be missed.  

This is the second half of the Disaster-Proofing your Herbal Business theme.Economic uncertainty is part of business – but there's so much you can do to make sure your business stays strong throughout the ups and downs.In the previous episode, we covered the first three steps in the work of diversifying your revenue streams and your product/service offerings to make sure that your herbal business keeps growing!In this episode, we're talking about expanding both your offerings and your target audience so that you can broaden your reach into more markets. This takes some creativity and some market research, but don't worry! It's not hard to do and this episode has plenty of tips. The most important take-away is that if you stay flexible and try several different ideas at a small scale to see what gets traction, shifting your business with the economic conditions becomes a lot less challenging.Most importantly though: you don't have to do all this alone! Join our Herbal Business Program and let's do it together! Not only will i personally help you, but you'll also have access to our private community of herbal business folks – so that you get a nurturing peer support group as well!The Herbal Business Program covers every aspect of GMP compliance, as well as every other part of running your business, from getting registered, paying taxes, and getting insurance to building your website and marketing without selling out – even hiring employees!All of our courses include twice weekly live Q&A sessions and you can ask questions in the discussion thread attached to every lesson – we answer them ever day! Plus we have a student community where you can get support from other business herbies too!If you have a moment, it would help us a lot if you could subscribe, rate, & review our podcast wherever you listen. This helps others find us more easily. Thank you!!Our theme music is “Wings” by Nicolai Heidlas.Support the showYou can find all of our online herbalism courses at online.commonwealthherbs.com!

In this episode of SCW for Pharma host Evren Ozkaya sits down with Audrey Greenberg, CEO and Founder of AG Capital Advisors, to explore the evolving landscape of CDMOs in the cell and gene therapy space.Audrey, who brings a finance background and deep industry insight, outlines what it takes to build and scale a CDMO business—from managing high fixed costs and staffing GMP operations to raising capital and building trust. She explains why earning the first million dollars in this space is often the hardest, and how their end-to-end manufacturing model, housed under one roof, simplifies pharma supply chains and reduces complexity for clients.Evren and Audrey explore the headwinds facing the industry, including geopolitical uncertainty, tariffs and capital scarcity. Audrey also highlights that, for gene and cell therapies, supply is currently outpacing demand. Despite the current uncertainties, she remains optimistic about company valuations and expects a rebound in the second half of 2025. In the meantime, she argues, digital transformation is not optional — it is the foundation for resilience and future valuation.They dive into how data, automation, and AI improve efficiency, reduce errors, and increase revenue. In a high-skill, high-cost environment—where PhDs often run the production floor—robotics and standardization become essential. Audrey also makes the case that digital maturity is more than an operational upgrade: it enhances customer trust, boosts EBITDA, and improves a CDMO's standing in an M&A-driven market.The conversation also touches on reshoring and the role of digitalization in helping the U.S. expand capacity without spiking drug prices. Audrey notes that reshoring began before COVID-19 but has gained urgency with recent tariff policies.The episode wraps with career advice for rising professionals: explore broadly, stay flexible, and understand both the operational and commercial sides of the business. Adaptability, Audrey says, is the most valuable skill in today's pharma world.

I'm joined today by Oliver Amdrup-Chamby, the co-founder of Puori and a true trailblazer in supplement transparency and quality. We break down everything you need to know to become a more informed consumer, from how to avoid hidden contaminants like heavy metals, pesticides, and microplastics, to why oxidation in fish oil is such a big deal, and the real story behind protein powders—especially the plant-based ones. Listeners of this podcast get 20% off of Puori protein, a one-time purchase or if you choose the already discounted subscription, you get almost a third off the price! Visit Puori.com/NAT and use my promo code NAT.   What we discuss: Supplements: contamination, purity, and Danish regulation ... 00:08:46 Fish oil: contaminants, microplastics, and oxidation ... 00:12:37 Fish oil quality: what to look for ... 00:15:19 Protein needs, trends, and bioavailability ... 00:24:08 Whey protein vs. plant protein ... 00:27:30 Making protein accessible for families ... 00:31:56 Heavy metals in protein powders ... 00:37:04 Sourcing and batch-level testing ... 00:41:19 Flavorings, sweeteners, and ingredient transparency ... 00:52:10 Tips for selecting clean protein and fish oil ... 01:07:36 Encouraging transparency and consumer advocacy ... 01:11:14   Our Amazing Sponsors: Profound Health -  - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Whatever your health needs, there's a bioregulator for you. Head to profound-health.com and use code NAT15 for 15% off your first order. CAROL Bike - With its cutting-edge, science-backed method, CAROL Bike can boost your VO2max by 12% in just 8 weeks—essentially rewinding your fitness clock by a decade. The folks at CAROL Bike are offering a 100-day FREE trial! Visit http://carolbike.pxf.io/Nat or use code NAT100 for a free 100-day trial. Quantum Upgrade - Imagine plugging yourself into a limitless power source. It's been rigorously tested and shown to improve blood flow, reduce stress, and even boost cellular energy by up to 29%. Try it today at quantumupgrade.io/NAT and start running life, instead of life running you. Use my code NAT15 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Economic uncertainty is part of business – but there's so much you can do to disaster-proof your herbal business and make sure it stays strong throughout the ups and downs.This episode is the first three steps in the work of diversifying your revenue streams and also your product/service offerings to make sure that your herbal business keeps growing!We're focusing here on how to shift your marketing so that your products/services remain essential as people tighten their budgets, as well as shifting which products or services you offer to make sure that you really do remain essential! In order to do that, you've got to really know your customers, and so we'll talk about exercises for how to do that, too. Taking the time to gather some data will help you to stay relevant and survive the budget cuts!And if your business is still in the planning stages, that's great – that means that you can be structuring your business to be economically resilient right from the start.Most importantly though: you don't have to do all this alone! Join our Herbal Business Program and let's do it together! Not only will i personally help you, but you'll also have access to our private community of herbal business folks – so that you get a nurturing peer support group as well!The Herbal Business Program covers every aspect of GMP compliance, as well as every other part of running your business, from getting registered, paying taxes, and getting insurance to building your website and marketing without selling out – even hiring employees!All of our courses include twice weekly live Q&A sessions and you can ask questions in the discussion thread attached to every lesson – we answer them ever day! Plus we have a student community where you can get support from other business herbies too!If you have a moment, it would help us a lot if you could subscribe, rate, & review our podcast wherever you listen. This helps others find us more easily. Thank you!!Our theme music is “Wings” by Nicolai Heidlas.Support the showYou can find all of our online herbalism courses at online.commonwealthherbs.com!

Contact Colin, and get help buying a vehicle here, via the GMP! WhatsApp - 00 351 913 590 303Enjoy content from Good Morning Portugal! published every day only on YouTube, please comment, like & subscribe.For 'resources for the rest of your life in Portugal', join the Portugal Club at www.theportugalclub.com for daily news, Portuguese language and culture, classroom, courses, calendar and community.Feeling lost, stuck or in need of inspiration? Or want friendly and positive support with your Portugal dream and plans? Try Carl's new consultancy service - by phone, on the web, over lunch, or enjoying a walk with him in his beloved Sao Martinho Bay.Review, evaluate and refine your Portugal Plan with Carl - for your best possible life here...Carl on Substack - https://carlmunson.substack.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

Nick Capman talks with Jesse Gillikan, President of cGMP Validation, about the challenges compounding pharmacies face with GMP compliance in 2025. After helping over 100 pharmacies navigate FDA regulations since the 2013 Drug Quality and Security Act, Jesse shares candid insights about this industry transformation.The conversation reveals how compounders have moved from resistance to acceptance of GMP requirements, though major hurdles persist. For 503B facilities, the primary challenge isn't knowledge but cost, particularly testing expenses that might be manageable for pharmaceutical giants making millions of units but become prohibitive for compounders producing just thousands.Jesse highlights practical space constraints, with many facilities not designed for GMP manufacturing. He recommends dedicating one-third of facility space to clean operations and another third to compliant warehousing, which targets many smaller operations that struggle to achieve.Jesse also sheds light on validation has shifted from qualifying individual technicians to validating entire processes, requiring completely new approaches to media fills and documentation. Despite these challenges, Jesse notes the industry's impressive information sharing and collaborative spirit.When discussing FDA inspections, Jesse emphasizes the importance of thorough deviation management — a common citation area. He also addresses the FDA shortage list volatility, sharing how clients invested in automated filling lines for GLP-1 products only to have those drugs removed from the list, creating significant business disruption.Jesse maintains that while compliance is non-negotiable, the FDA genuinely wants compounders to succeed. His practical advice focuses on risk-based prioritization, industry collaboration, and maintaining open communication with regulators._____The FDA Group connects compounding pharmacies with specialized consultants who understand the unique challenges of 503B compliance. Our experts provide practical solutions that balance regulatory requirements with business viability – from GMP implementation and environmental monitoring to documentation systems and FDA inspection support. Visit https://www.thefdagroup.com/ for more information.

Today, I'm joined by Ulrich Dempfle, the innovative mind behind the CAROL Bike. Ulrich's journey is fascinating—he started as a mechanical engineer in Europe, became a pioneer in hospital AI systems, and is now laser-focused on bringing cutting-edge fitness tech to regular people, like you and me.   What we discuss: Zone 2 training: hype, benefits, and limitations ... 00:08:00 VO2 max: definition and importance for longevity ... 00:10:00 The impracticality and issues with Zone 2 for most people ... 00:15:00 Downsides of long-duration steady-state cardio ... 00:18:00 Why strength and mobility also matter ... 00:17:00 Carol Bike and REHIT: efficient fitness for longevity ... 00:31:00 REHIT's proven VO2 max and metabolic improvements ... 00:36:00 Personalization and ease-of-use with Carol Bike ... 00:49:00 Carol Bike's versatility: multiple workouts and app integrations ... 00:57:00 Who Carol Bike is for and safety notes ... 01:10:00 Carol Bike trial info, research, and closing ... 01:12:00   Our Amazing Sponsors: Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at  troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. Timeline: Mitopure®️ is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10. Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Whatever your health needs, there's a bioregulator for you. Head to profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Join the WhatsApp group at - https://chat.whatsapp.com/FPcy5VmPWBp1ePIlu9PdmoWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

In this episode, Aouda Ouzza is helping us understand when the Regulatory Affairs person is needed during the design phase. The problem that we will uncover here is the fact that in most cases the design team are calling the Regulatory Affairs person on a project when they have finished everything and they need this person to take care of the registration before launch. But this is wrong, and we'll let you know when and why you should involve them earlier. Listen to this episode.  Who is Aouda Ouzzaa?  Aouda Ouzzaa brings over 16 years of expertise in Regulatory Affairs (RA) and Quality Assurance (QA), supporting the entire product lifecycle—from development to post-market surveillance. She has successfully led projects across pharmaceuticals, biologics, medical devices (EU MDR), cosmetics, and Software as a Medical Device (SaMD).  Her global regulatory knowledge spans EMA, FDA, GCC, and Rest of World (ROW) markets. Aouda has hands-on experience preparing IND, BLA submissions, and securing orphan drug designations.  As a certified GMP and GDP auditor, Aouda has worked closely with cross-functional teams to ensure compliance with international standards while optimizing regulatory interactions. Her methodical approach and deep understanding of complex regulatory environments make her a strategic asset for organizations navigating global compliance challenges.  Whether you're developing a new drug, launching a medical device, or scaling a digital health solution, Aouda Ouzzaa brings the insight and precision needed to achieve regulatory success.    Who is Monir El Azzouzi?  Monir El Azzouzi is the founder and CEO of Easy Medical Device a Consulting firm that is supporting Medical Device manufacturers for any Quality and Regulatory affairs activities all over the world. Monir can help you to create your Quality Management System, Technical Documentation or he can also take care of your Clinical Evaluation, Clinical Investigation through his team or partners. Easy Medical Device can also become your Authorized Representative and Independent Importer Service provider for EU, UK and Switzerland.  Monir has around 16 years of experience within the Medical Device industry working for small businesses and also big corporate companies. He has now supported around 100 clients to remain compliant on the market. His passion to the Medical Device filed pushed him to create educative contents like, blog, podcast, YouTube videos, LinkedIn Lives where he invites guests who are sharing educative information to his audience. Visit easymedicaldevice.com to know more.  Link Aouda Ouzza LinkedIn Profile: linkedin.com/in/aouda-ouzzaa-51877a32  SmartQARA website: https://smartqara.com/  Social Media to follow Monir El Azzouzi Linkedin: https://linkedin.com/in/melazzouzi Twitter: https://twitter.com/elazzouzim Pinterest: https://www.pinterest.com/easymedicaldevice Instagram: https://www.instagram.com/easymedicaldevice Authorized Representative and Importer services:https://easymedicaldevice.com/authorised-representative-and-importer/  

Full interview - https://youtu.be/RU9YNzY3Rr4Some great additional commentary following on from GMP!'s recent 'Integration Myth' interview with Simone Torres Costa - https://youtu.be/hIz_BH1U5ssEnjoy content from Good Morning Portugal! published every day only on YouTube, please comment, like & subscribe.For 'resources for the rest of your life in Portugal', join the Portugal Club at www.theportugalclub.com for daily news, Portuguese language and culture, classroom, courses, calendar and community.Are you ready for 'The Conversation' with Carl Munson? Find out more at https://www.goodmorningportugal.com/the-conversation Carl on Substack - https://carlmunson.substack.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

Great to hear from our good buddy João Do Norte, who's in America, and learn about what he's enjoying back in his native USA, whilst missing a few things he's grown to love in Portugal.Also some great additional commentary following on from GMP!'s recent 'Integration Myth' interview with Simone Torres Costa - https://youtu.be/hIz_BH1U5ssEnjoy content from Good Morning Portugal! published every day only on YouTube, please comment, like & subscribe.For 'resources for the rest of your life in Portugal', join the Portugal Club at www.theportugalclub.com for daily news, Portuguese language and culture, classroom, courses, calendar and community.Are you ready for 'The Conversation' with Carl Munson? Find out more at https://www.goodmorningportugal.com/the-conversationBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

On this episode of the Longevity Podcast, host Nathalie Niddam is joined by renowned cardiologist and bestselling author Dr. William Davis for a deep dive into the powerful connection between gut health, the microbiome, and vibrant longevity. Dr. Davis—who made waves with his groundbreaking books Wheat Belly and Super Gut—shares his journey from mainstream cardiology to pioneering work on the true drivers behind chronic disease, fat gain, and aging.   What we discuss: Meet Dr. William Davis & Wheat Belly origins ... 00:04:00 From cholesterol to calcium scoring ... 00:10:00 Dramatic health wins from removing wheat, grains, sugar ... 00:14:00 Transition to the microbiome & SIBO ... 00:19:00 Modern SIBO causes and prevalence ... 00:24:00 SIBO yogurt strategy and benefits ... 00:31:00 Women's health, pregnancy, and key microbes ... 00:47:00 Actionable gut health tips and food swaps ... 01:03:00 Fermentation: dos and don'ts ... 01:21:00 Where to find Dr. Davis and wrap-up ... 01:23:00   Our Amazing Sponsors: Peptide Pro App: can help manage every part of your peptide protocol. From smart scheduling to real-time dose checklists, note taking, and easy calculations. Listeners receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today.   Puori - 21 grams of high-quality whey protein from pasture-raised cows with no hormones, GMOs, or pesticides. Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order!   Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Head to profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Send us a textSupplements are an important tool in today's world where our food has fewer nutrients than in the past, but taking them without understanding why or choosing low-quality brands can waste money and potentially harm health. We explore the top three mistakes people make with supplements and how to choose products that genuinely support your body's needs.• Mistake #1: Relying on supplements instead of focusing on a nutrient-dense diet and lifestyle changes• Mistake #2: Buying supplements without checking brand credibility – 4 out of 5 supplements from major retailers don't contain the herbs listed on labels• Mistake #3: Taking supplements without a clear reason or understanding if they're actually helping• Look for third-party certifications like NSF, GMP, ISO, or IFOS (for fish oil) when purchasing supplements• Consider working with a practitioner who can help identify what supplements will specifically support your needs• Use lab testing to make data-backed decisions about supplementation rather than guessingFREE RESOURCE DESIGNED FOR WOMEN IN SALESUnlocking Peak Performance: A Hormonal Guide for Women in Sales

"Olá Bom Dia ALEGRIA! Munson here with the Good Morning Portugal! show, livestream & podcast. Tudo bem?"We start the show with the 'Bom Dia Daily' - 20 minutes of news, weather, language, culture & wellbeing in Portugal, by way of an introduction today to GMP!'s monthly business world update, with...Lighthouse Consulting's Raquel, who'll be looking at contingency and legacy in the business world, as GMP! Preparedness Week continues.Our friend Nuno Mendes also back talking about the role of insurance in the 'rest of your life in Portugal'.Comments in the chat, pics & vids to WhatsApp (00 351) 913 590 303Get more at www.goodmorningportugal.com / Support the show and join the Portugal Club at www.gmpvip.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

It's GMP! Preparedness Week (more at www.theportugalclub.com) so Munson and the Geeza *might* take a look at some of the many aspects of Maya Angelou's idea: “hoping for the best, prepared for the worst, and unsurprised by anything in between.” Where are you in this mix?And how are YOU preparing for the future in these times?Want to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

The Matt Walker Podcast✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Dr. Cheri Mah returns to the podcast today to explore a few different topics including how circadian rhythms shape athletic performance. She notes that these 24-hour cycles regulate sleep, hormones, and core temperature, with peak physical capacity often occurring between 4-8 pm—when many world records are set. Dr. Mah also discusses chronotypes, showing how tailoring training to one's natural rhythm can enhance results. She reveals research on circadian disruption in sports, notably how West Coast NFL teams outperform East Coast teams in night games due to a three-hour body clock advantage. The episode also covers jet lag strategies, sleep loading, and managing fatigue, making it a must-listen not just for athletes and high performers, but truly for us all. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Matt is only too happy to share the fact that launching his sleep-related merchandise sales was incredibly smooth, thanks to show sponsor Shopify and their integrated sales and inventory system. And now, just for you,  Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now! One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase. Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.Matt: Instagram @drmattwalker or on X @sleepdiplomatYouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Connect with Dr. Mah: https://www.drcherimah.com/ or https://linktr.ee/drcherimahCaffeine Nap Episode: https://podcasts.apple.com/us/podcast/58-caffeine-nap/id1578319619?i=1000630666364Chronotype Assessment: AutoMEQ: Automated Morningness-Eveningness Questionnaire (AutoMEQ)

The Matt Walker Podcast✓Claim Key Takeaways  For every new time zone that you cross, it takes approximately one day for your body to acclimate The difference between circadian rhythm and chronotype: Circadian rhythm is your body's internal 24-hour clock that regulates biological processes, while chronotype is your natural preference for when you feel most alert or sleepy within that rhythmTop sleep tips from the episode:Maintain the same sleep schedule on weekdays and weekendsGo to bed and wake up at the same time, or at least within a 30 min windowReduce effects of jet-lag by taking pre-flight, in-flight, and post-flight measuresKnow your chronotype so you can performance-peak at desired times Over 40 NFL seasons from 1970-2011, during night match-ups, the West coast team was two-fold more likely to beat the East coast team This is due to the West coast team's circadian advantage over the East teamLeverage “Sleep Loading”: Before going into a high-stress period or an acute period in which you will be sleeping less, increase your sleep duration in the several days leading up the period of anticipated sleep-loss or higher-stress While it is difficult to “pay back” sleep debt after-the-fact, it appears that you can build up “sleep credit” by front-loading sleep ahead of anticipated periods of high stress and sleep-lossTaking a hot shower or bath 90 minutes before bed can dramatically improve your sleep quality A study conducted using the NBA schedule was able to predict game outcomes with 76-86% accuracy based on travel-induced fatigue criteria – completely independent of strength of team Use the nappuccino to boost alertness and performance: Consume your favorite caffeinated beverage, immediately take a 20-30 minute power nap, then wake up when your alarm goes off and you will be in a heightened state of alertness Read the full notes @ podcastnotes.orgDr. Cheri Mah returns to the podcast today to explore a few different topics including how circadian rhythms shape athletic performance. She notes that these 24-hour cycles regulate sleep, hormones, and core temperature, with peak physical capacity often occurring between 4-8 pm—when many world records are set. Dr. Mah also discusses chronotypes, showing how tailoring training to one's natural rhythm can enhance results. She reveals research on circadian disruption in sports, notably how West Coast NFL teams outperform East Coast teams in night games due to a three-hour body clock advantage. The episode also covers jet lag strategies, sleep loading, and managing fatigue, making it a must-listen not just for athletes and high performers, but truly for us all. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Matt is only too happy to share the fact that launching his sleep-related merchandise sales was incredibly smooth, thanks to show sponsor Shopify and their integrated sales and inventory system. And now, just for you,  Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now! One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase. Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.Matt: Instagram @drmattwalker or on X @sleepdiplomatYouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Connect with Dr. Mah: https://www.drcherimah.com/ or https://linktr.ee/drcherimahCaffeine Nap Episode: https://podcasts.apple.com/us/podcast/58-caffeine-nap/id1578319619?i=1000630666364Chronotype Assessment: AutoMEQ: Automated Morningness-Eveningness Questionnaire (AutoMEQ)

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2948: Dr. Neal Malik breaks down how to choose safe, effective supplements in a largely unregulated industry. He explains why looking for third-party certifications like USP, NSF, and GMP can protect your health, and your wallet, by ensuring you're getting exactly what the label promises. Quotes to ponder: "One study found that 15% of protein supplements sold contain banned substances like amphetamines and anabolic steroids." "The more certifications we find on a supplement's packaging, the better." "If you can find a product that has a USP, NSF, and GMP certification, then that's a pretty safe purchase." Episode references: United States Pharmacopeia (USP): https://www.usp.org National Sanitation Foundation (NSF): https://www.nsf.org/consumer-resources/what-is-nsf-certification Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2948: Dr. Neal Malik breaks down how to choose safe, effective supplements in a largely unregulated industry. He explains why looking for third-party certifications like USP, NSF, and GMP can protect your health, and your wallet, by ensuring you're getting exactly what the label promises. Quotes to ponder: "One study found that 15% of protein supplements sold contain banned substances like amphetamines and anabolic steroids." "The more certifications we find on a supplement's packaging, the better." "If you can find a product that has a USP, NSF, and GMP certification, then that's a pretty safe purchase." Episode references: United States Pharmacopeia (USP): https://www.usp.org National Sanitation Foundation (NSF): https://www.nsf.org/consumer-resources/what-is-nsf-certification Learn more about your ad choices. Visit megaphone.fm/adchoices

"Olá Bom Dia ALEGRIA! Munson here with the Good Morning Portugal! show, livestream & podcast. Tudo bem?"We start the show with the 'Bom Dia Daily' - 20 minutes of news, weather, language, culture & wellbeing in Portugal, by way of an introduction today to... Veronica, the legendary American in Portugal (Algarve), and Carl Hyde, the Brit in Lisbon, with their professional and personal insight from their respective parts of the country.Today, on day four of GMP! Preparedness Week, they will also address the fascinating question: "where would YOU buy - for the rest of your life - in Portugal?"Comments in the chat, pics & vids to WhatsApp (00 351) 913 590 303Get more at www.goodmorningportugal.com / Support the show and join the Portugal Club at www.gmpvip.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

Dave and Ben announce their long-anticipated collaboration with wrestling legend Diamond Dallas Page on a new USDA-certified organic vegan protein powder that's been in development for over a year and a half.• Dave recounts how he initially met DDP through a cybersecurity speaking engagement• The relationship evolved from friendship to business partnership as DDP wanted to create an organic protein product• Creating the protein involved over 200 iterations to perfect the taste, ingredients, and packaging • The product is 100% GMP certified, USDA organic certified, vegan, and gluten-free• New products coming soon include a green apple pre-workout with increased AlphaGPC• Future product plans include an essentials range with properly dosed vitamins and minerals• The team discusses their commitment to transparency in ingredients and proper dosing• Ben and Dave share workout programming recommendations for beginnersIf you're interested in our organic vegan protein with DDP or other Hacking Your Health supplements, keep an eye on our website as we'll be launching these new products very soon.Check us out here: https://www.hackingyourhealth.com/ Support the showCheck out Overclock and Protein Protocol hereWant to know more about coaching? Book a call with Ben here Where to find usWe Hack Health: TwitterWe Hack Health: InstagramWe Hack Health: Discord

In this latest AMA episode, Matt and Dr. Eti Ben Simon tackle even more listener questions regarding any and all aspects of sleep. Today, they discuss sleep tracker accuracy, noting that while nightly data isn't perfect (~75-85% accurate), weekly trends are reliable. Feeling exhausted despite good tracker metrics? Potential causes include fragmented sleep, circadian issues, undiagnosed disorders (like apnea), or tracker-induced anxiety (orthosomnia). Matt and Eti stress consulting a specialist for persistent fatigue and focusing on long-term data patterns.They also explore why many wake around 3:30 AM, linking it to shifts into lighter sleep stages and hormonal changes (cortisol rise, melatonin drop). The hosts explain alpha wave intrusion's link to nonrestorative sleep, theories behind teeth-falling-out dreams (trigeminal nerve activity), and differing sleep onset times (partner variations, potential sleep debt). They also touch upon how antidepressants affect dream recall via REM sleep reduction and debunk precognitive dreams, attributing them to statistics and cognitive bias, not prophecy.Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Matt will be the first to tell you that launching his sleep-related merchandise sales was incredibly smooth, thanks to our new sponsor Shopify and their integrated sales and inventory system. And now, just for you,  Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now! Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.As always, if you have thoughts or feedback you'd like to share, please reach out to Matt or Eti:Matt: Instagram @drmattwalker, X @sleepdiplomat, YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/,  or email at etoosh@gmail.com

Today's guest, Dr. Gregory Kelly, creator of Qualia Mind, has spent years studying how to help people think faster, age better, and avoid that 3 p.m. crash that turns you into a zombie.  If you've ever wished for an extra gear in your mental engine, this is the episode for you! And if you are interested in giving it a try, visit qualialife.com/nathalie and use promo code NATHALIE to save 15% on your order.    What we discuss: Difference Between Brain and Mind ... 00:07:03 Mental Energy and Brain Function ... 00:09:49 Glucose and Ketones as Brain Fuel ... 00:17:45 Nootropic Supplements and Their Impact ... 00:24:53 Stacking Compounds for Cognitive Performance ... 00:34:07 Short-term and Long-term Benefits of Ingredients ... 00:43:18 Using Nootropics Like Qualia Mind for Performance ... 00:52:28 Safety and Effectiveness of Ingredient Stacking ... 01:16:40 Five Tips for Maintaining Cognitive Energy ... 01:19:15 Conclusion and Final Thoughts ... 01:26:28   Our Amazing Sponsors: STEMREGEN - Triggers the release of 10 million of your own stem cells, supporting tissue repair, recovery, and overall longevity. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   BEAM - These minerals come from humate, a natural substance formed over millions of years as freshwater plants broke down and deposited their nutrients into the soil. Over time, those minerals concentrated into this black, crystalline material that's now one of the most mineral-dense substances on earth. Visit https://www.beamminerals.com/NAT20 and use code NAT20 for 20% off.   Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Head to profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

A GMP! outside broadcast..."Olá Bom Dia ALEGRIA! Munson here with the Good Morning Portugal! show, livestream & podcast. Tudo bem?"We start the show with the 'Bom Dia Daily' - 20 minutes of news, weather, language, culture & wellbeing in Portugal, by way of an introduction today to... A LIVE show the Storytellers Palace in Carl's hometown this morning, home of a warm family welcome in a 5-star ambience!Get a sense of the leisurely luxury on offer as the show comes LIVE from the hotel, after a legendary Storytellers breakfast.What's YOUR favourite hotel in Portugal?Comments in the chat, pics & vids to WhatsApp (00 351) 913 590 303Get more value at www.goodmorningportugal.com / Support the show and join the Portugal Club at www.gmpvip.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

The Good Morning Portugal! Wine Club has been trying and celebrating Portuguese wines, and other nationally-loved drinks, since 2020.On this occasion, we will meet online at 8pm for a live tasting of what the GMP! Wine Ninjas have chosen for a Portuguese white wine for €10 or more.Does the added expenditure add up in quality and taste?Thereafter at 8.30pm, GMP!VIPs are invited to an off-line, lock-in for further savouring and putting the world to rights!Join us every first Monday of the month for the GMP! WINE CLUB and become a GMP!VIP at www.gmpvip.comEnquiries: carl@goodmorningportugal.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

In this episode, we're joined by Chelsea Burkett, Deputy Program Director with AECOM[00:01:13] Meet Chelsea BurkettChelsea introduces her role with Aecom and the scope of Austin ISD's massive bond program.[00:02:29] GMP 101A foundational look at GMP pricing and how it supports collaborative delivery models.[00:03:37] Early GC InvolvementWhy selecting general contractors early creates synergy and reduces surprises.[00:05:23] Community-Driven Design = Scope Creep?How community input shapes schools—and complicates budgets.[00:06:38] What's in a GMP?Chelsea walks through what the contract amendment includes and how it's executed.[00:08:49] Staying in BudgetThe bond book, voter expectations, and how cost alignment is maintained.[00:11:13] Supply Chain ChaosMaterial pricing, long lead times, and how GCs manage risk today.[00:15:24] The Open Book AdvantageFull transparency into sub bids, contingencies, and value engineering.[00:17:02] The Grading GameHow GCs and subs are evaluated—points, interviews, and all.[00:20:28] Risk, Clarifications & AllowancesUnpacking who owns what risk in complex multi-GMP projects.[00:24:07] Liquidated Damages & DeadlinesWhy hitting school opening day is non-negotiable—and risky.[00:30:12] The Art of NegotiationNavigating owner–GC–architect dynamics for long-term project health.[00:34:08] Tariffs & Steel ShockwavesThe ripple effects of global politics on your jobsite.[00:36:09] Fee StrategyHow GCs compete on cost and credentials—and when they ask for more.[00:37:03] Chelsea's Pain PointsWhy early communication is everything in GMP negotiations.[00:41:19] Use the PMIS!Advice to subs: use project management systems to get seen and heard.[00:43:14] People MatterHow staffing and turnover shape success across multiple projects.[00:46:00] Smart Strategy ≠ Low BidThe delicate dance of rewarding excellence while staying fair.[00:48:35] Megaphone MomentChelsea's call to the industry: prioritize relationships over ego.Go build something awesome!CHECK OUT THE PARTNERS THAT MAKE OUR SHOW POSSIBLE: https://www.brospodcast.com/partnersFIND US ONLINE: -Our website: https://www.brospodcast.com -LinkedIn:   / constructionbrospodcast   -Instagram:   / constructionbrospodcast    -TikTok: https://www.tiktok.com/@constructionbrothers?lang=en-Eddie on LinkedIn:   / eddie-c-057b3b11   -Tyler on LinkedIn:   / tylerscottcampbell  If you enjoy the podcast, please rate us on Apple Podcasts or wherever you listen to us! Thanks for listening!

What's Good Famiglia?! How we doin out there?! We're changing it up a little bit this week. I got a chance to chop it up with the homie Ryan, CEO and founder of Doja Pak, at Hall of Flowers in Ventura a couple weeks ago. We had a real dope conversation about the future of worldwide cannabis, and all of the possibilities that come with the new wave on the global scene. It was a very inspiring conversation and shed a lot of light on what's happening outside of California cannabis. We covered everything from the importance of stacking your genetic IP, Doja BCN, what it takes to build a worldwide brand, and how cannabis will be sold from country to country through the GMP.  Watch this one all the way to the end, trust me! Y'all know what time it is… Roll em fat, torch your rigs, pack your bongs, bag up some work, water your plants, do what you gotta do because we're about to take this journey around the world with the homie Ryan from Doja Pak!✌

Dr. Cheri Mah returns to the podcast today to explore a few different topics including how circadian rhythms shape athletic performance. She notes that these 24-hour cycles regulate sleep, hormones, and core temperature, with peak physical capacity often occurring between 4-8 pm—when many world records are set. Dr. Mah also discusses chronotypes, showing how tailoring training to one's natural rhythm can enhance results. She reveals research on circadian disruption in sports, notably how West Coast NFL teams outperform East Coast teams in night games due to a three-hour body clock advantage. The episode also covers jet lag strategies, sleep loading, and managing fatigue, making it a must-listen not just for athletes and high performers, but truly for us all. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Matt is only too happy to share the fact that launching his sleep-related merchandise sales was incredibly smooth, thanks to show sponsor Shopify and their integrated sales and inventory system. And now, just for you,  Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now! One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase. Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.Matt: Instagram @drmattwalker or on X @sleepdiplomatYouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Connect with Dr. Mah: https://www.drcherimah.com/ or https://linktr.ee/drcherimahCaffeine Nap Episode: https://podcasts.apple.com/us/podcast/58-caffeine-nap/id1578319619?i=1000630666364Chronotype Assessment: AutoMEQ: Automated Morningness-Eveningness Questionnaire (AutoMEQ)

In this episode of SCW for Pharma, host Evren Ozkaya welcomes Fabrice Le Garrec, Founder of The OSICS Network and a global authority on Lean manufacturing and operational excellence.Fabrice sheds light on the inefficiencies plaguing the pharmaceutical industry, particularly its heavy reliance on outdated processes, paper, and spreadsheets. Drawing comparisons with advanced industries like automotive, he argues that GMP regulations shouldn't be an excuse for inefficiency.The conversation emphasizes the critical role of Lean manufacturing in boosting performance, productivity, and cost savings. Evren and Fabrice point out the shocking disparity in Overall Equipment Effectiveness (OEE): just 35% in pharma compared to 80-85% in consumer industries. Fabrice claims with existing maturity levels almost any pharma manufacturer can achieve a 20-30% productivity boost within the first year of Lean implementation, even without significant investment.  He claims the ROI is clear—optimizing changeovers, eliminating paperwork, and enhancing visibility through digital tools can generate millions in savings annually for medium-sized pharma factories.Fabrice highlights the synergy between Lean practices and digital transformation, noting that their combination can significantly amplify their impact. However, he cautions that digital tools are ineffective unless paired with a problem-solving culture. His advice for digital factory transformation is to start with simple, integrated systems, beginning with enhancing shop floor visibility, and then building execution, scheduling, and compliance systems upon that foundation.With rising tariffs and escalating costs, Fabrice underscores the urgency of optimizing existing sites rather than building new ones. Boosting OEE from 35% to 70% can double output without additional facilities—offering a cost-effective, time-efficient path forward. He also added, tariffs can negatively impact drug prices and availability.

Revolutionary €8 Million EU-Funded Project Aims to Restore Vision for Millions with Cutting-Edge Bioprinting Technology to tackle Corneal Blindness A groundbreaking initiative is set to transform the future of vision restoration with the launch of KeratOPrinter, an €8 million EU-funded project pioneering an advanced bioprinting suite capable of producing fully functional, biocompatible, full-thickness human corneas. A Global Solution to Corneal Blindness Corneal blindness is the third leading cause of blindness worldwide, affecting millions of people. Yet, due to an alarming shortage of donor tissue, many patients remain unable to access life-changing corneal transplants. The KeratOPrinter project is tackling this urgent healthcare challenge by developing an innovative 3D bioprinting technology that can replicate the complex structure and functionality of the human cornea - bringing hope to millions in need. Why KeratOPrinter is a Game-Changer Bridging the Global Cornea Shortage: By bioprinting full-thickness, optomechanicallyfunctional corneas, this project has the potential to revolutionize the field of ophthalmology, offering an alternative to limited donor tissues. Real-World Clinical Application: The project integrates Good Manufacturing Practice (GMP)-compliant workflows and AI-driven quality control mechanisms to ensure consistency, reliability, and safe clinical translation. Economic and Societal Impact: By delivering a scalable, cost-effective solution to corneal transplantation, KeratOPrinter will lower production costs, improve access to treatment, and enhance the quality of life for millions, particularly in vulnerable populations. A European Collaboration Driving Innovation The KeratOPrinter project brings together a powerhouse consortium of nine partners from five EU countries - Finland, Germany, Spain, the Netherlands, and Ireland. This multidisciplinary collaboration includes leading research institutes, small and medium-sized enterprises (SMEs), and industry specialists in stem cell differentiation, biomaterials, bioprinter devices, regulatory affairs, and clinical ophthalmology. The project also features state-of-the-art transport solutions, including portable incubators with active CO? and temperature control, ensuring the safe delivery of living cells and biological samples under optimal conditions. Expert Insights: A Visionary Approach to Bioprinting Professor Heli Skottman, KeratOPrinter coordinator from the Faculty of Medicine and Health Technology at Tampere University, Finland, highlights the significance of this initiative: "The KeratOPrinter project has strategically assembled a world-class consortium to develop an innovative bioprinting technology capable of producing standardized, biocompatible, and hypoimmunogenic full-thickness corneas in a scalable, GMP-compliant manner." She further adds: "Corneal blindness is driven by a wide spectrum of ophthalmic conditions requiring corneal transplants. However, the severe global shortage of donor tissue is a major barrier to effective treatment. The KeratOPrinter project presents a revolutionary solution, using cutting-edge technology to address this critical medical challenge." A Bold Step Towards Restoring Vision By harnessing the power of advanced bioprinting technology, the KeratOPrinter project is set to redefine corneal transplantation, making vision-restoring therapy more accessible, efficient, and sustainable. With its transformative impact on ophthalmology, this project marks a new era in regenerative medicine. About KeratOPrinter KeratOPrinter is an EU-funded research project dedicated to developing cutting-edge bioprinting solutions for corneal transplantation. By combining expertise from multiple disciplines, the project aims to produce a scalable, clinically viable solution to address the global challenge of corneal blindness. For more information about the KeratOPrinter project and its initiatives, visit the official project website at htt...

What if I told you that one of the biggest secrets to staying young, fighting disease, and even keeping your heart and arteries in top shape isn't just about hitting the gym or eating clean?   Products mentioned in this episode: Lypo-Spheric® Vitamin C Sodium Ascorbate Powder   What we discuss: The Role of Oxidative Stress and Vitamin C ... 00:03 Introduction of Dr. Thomas Levy and His Journey ... 00:07 Oxidative Stress and Its Impact on Health ... 00:08 Exercise, Hormones, and Antioxidants ... 00:19 Critical Importance of Oral Health ... 00:30 Heavy Metals and Heart Health ... 00:45 Chelation and Detoxification Methods ... 00:47 Long COVID, Spike Protein, and Vitamin C Protocol ... 00:52 Discussion on Vitamin C Sources and Supplementation ... 01:00 Conclusion and Contact Information for Dr. Levy ... 01:06   Our Amazing Sponsors: Mitolux - Most therapy lamps just blast bright light at you, but Mitolux actually mimics real sunlight and includes red light therapy for extra wellness perks. Get a Mitolux Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout.   Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're GMP and HACCP certified and FDA-compliant. Visit profound-health.com and use code NAT15 for 15% off your first order. Timeline: Mitopure is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

"Olá Bom Dia ALEGRIA! Munson here with the Good Morning Portugal! show, livestream & podcast. Tudo bem?" We start the show with the 'Bom Dia Daily' - 20 minutes of news, weather, language, culture & wellbeing in Portugal, by way of an introduction today to...GMP!'s monthly business world update, and... Coach Turner joins us from the UK with his view on the best approach to gentle fitness for bon-viveurs. Ian's GOD Squad program can now be found at - www.gmpvip.comAlso with us, Astrid of Expats Portugal, with an EP premium member benefit update AND a Coimbra reminder! Let's look at the weekend ahead too with a Feelgood Friday vibe (-:Comments in the chat, pics & vids to WhatsApp (00 351) 913 590 303Get more at www.goodmorningportugal.com / Support the show and join the Portugal Club at www.gmpvip.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

"Olá Bom Dia ALEGRIA! Munson here with the Good Morning Portugal! show, livestream & podcast. Tudo bem?"We start the show with the 'Bom Dia Daily' - 20 minutes of news, weather, language, culture & wellbeing in Portugal, by way of an introduction today to...GMP!'s monthly business world update, and... Lighthouse Consulting's Raquel, who'll be looking at how to cope when the proverbial hits the fan, and sharing news of her new mini-series about entrepreneurship in Portugal.Our mate Nuno Mendes also back talking about AI and digital interventions in business that don't dispense with the 'personal touch' - the best of both worlds.Comments in the chat, pics & vids to WhatsApp (00 351) 913 590 303Get more at www.goodmorningportugal.com / Support the show and join the Portugal Club at www.gmpvip.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

Please join us as I interview Gary LIVE on a special evening GMP! session.GMP! Mastermind group members will enjoy a private audience with Gary from 8.30pm, join them here - https://ko-fi.com/gmpWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

In today's episode, I'm thrilled to share a captivating conversation with Dr. Robert Lufkin, a distinguished physician and medical school professor.  Dr. Lufkin, the author of the groundbreaking book "Lies I Taught in Medical School," offers unique insights from his perspective within the medical establishment. We dive deep into the shortcomings of modern medicine, especially when it comes to addressing chronic diseases like obesity, diabetes, and cardiovascular issues.    What We discuss: Dr. Lufkin's Background and Perspective ... 00:07:21 Modern Medicine and Chronic Disease Challenges ... 00:11:48 Dr. Lufkin's Personal Health Journey ... 00:13:37 Importance of Lifestyle in Medical Treatment ... 00:17:39 Type 2 Diabetes and Aging ... 00:28:11 Perspective on Cardiovascular Health ... 01:01:16 Discussion on Statins ... 01:04:16 General Practitioner Role and Medical System ... 00:21:33 Diet and Nutritional Insights ... 00:43:23 Fasting and Metabolic Health ... 00:51:15 Stress Management and Childhood Events Impact ... 00:38:45 Dr. Lufkin's Views on Supplements ... 01:09:35 Where to Find Dr. Robert Lufkin's Book ... 01:12:25   Our Amazing Sponsors: Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Whatever your health needs, there's a bioregulator for you. Head to profound-health.com and use code NAT15 for 15% off your first order.  Puori - 21 grams of high-quality whey protein from pasture-raised cows with no hormones, GMOs, or pesticides. Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order! Timeline - Improve your cellular energy, strengthen muscle, and boost endurance by taking Mitopure daily. Mitopure unlocks 6x more Urolithin A than diet alone. Visit timeline.com/nat10 for 10% off.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Our host, Gareth McGlynn, welcomes back Bob Kovacs, Director of Preconstruction at Albion General Contractors, for another insightful conversation. Having previously joined us in 2022, Bob returns to discuss his career shift and key industry topics shaping preconstruction today.Discussion Highlights:

Matt and Dr. Eti Ben Simon team up to answer more audience questions today, and begin by delving into the subjective experience of time during dreams, exploring how our perception stretches and compresses during REM sleep and whether we can hack our dreams. They also explain the cognitive, emotional, hormonal, and immunological consequences of pulling an all-nighter, highlighting the dramatic impact on memory consolidation, stress hormones, appetite regulation, and immune function. The cardiovascular and metabolic repercussions are also addressed underscoring the serious health risks associated with chronic sleep deprivation.The discussion shifts to the societal bias favoring morning types, challenging the notion that evening types are simply lazy. Our hosts examine chronotypes, the “sentinel hypothesis”, and the importance of aligning sleep schedules with individual preferences for optimal health. Matt and Eti then draw the episode to a close by addressing the common phenomenon of night sweats, differentiating between pathological causes and the normal thermoregulatory disconnect during REM sleep.Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of protein. Ready to experience the Puori difference? Matt's listeners get 20% off, so visit puori.com/mattwalker today!Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.As a health fanatic, Matt's kryptonite has always been bread. Then he discovered Hero Bread: zero net carbs, zero sugar, and packed with fiber! For years, he's enjoyed their fluffy loaves (his favorite topped with tomatoes, balsamic, and parmesan). Now, you can try it too! Hero Bread offers a delicious variety of healthy bread options, from tortillas and wraps to bagels and dinner rolls. Ready to enjoy bread again? Get 10% off your order at hero.co using code MATTWALKER.As always, if you have thoughts or feedback you'd like to share, please reach out to Matt or Eti:Matt: Instagram @drmattwalker, X @sleepdiplomat, YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/,  or email at etoosh@gmail.com

CF Dad Bob Coughlin see's a cure in the future for his son, and all of our kids. His high energy in this podcast is contagious. In this conversation, Laura Bonnell and Bob Coughlin discuss the journey of Bob's son, Bobby, who has cystic fibrosis. They explore the advancements in treatment, the importance of advocacy, and the intersection of policy and innovation in the biotechnology sector. Bob shares his personal experiences as a caregiver and advocate, emphasizing the need for continued support and education in the medical community. The conversation highlights the emotional rollercoaster of living with a chronic illness and the hope brought by new therapies. In this conversation, Bob Coughlin shares his emotional journey as a parent of a child with cystic fibrosis, detailing the transformative impact of new treatments and the importance of community support. He discusses the hope brought by advancements in gene therapy and the future of cystic fibrosis treatment, emphasizing the need for continued advocacy and innovation in healthcare. The conversation highlights the emotional highs and lows experienced by families dealing with chronic illness and the importance of maintaining a positive outlook.Bob aligns real estate strategies with scientific business objectives. Which is very cool if you ask me. He's on numerous boards and is extremely involved in work, life and organizations.___________________________Bob Coughlin is a Managing Director at JLL and is the New England's Life Science and Healthcare Practice Group lead. He specializes in the representation of lab, GMP manufacturing and technology space. Robert delivers creative solutions that align real estate strategies with scientific business objectives. ExperienceRobert most recently operated as the President & CEO of the Massachusetts Biotechnology Council, where his mission was to advance Massachusetts's leadership in the life sciences to grow the industry. Robert has spent his career in both the public and private sectors. Before joining MassBio, he served as the Undersecretary of Economic Development within Governor Deval Patrick's administration, where he prioritized both healthcare and economic development issues and was a strong advocate for the life sciences industry in Massachusetts. Prior to that, he was elected as State Representative to the 11th Norfolk district for three terms. Robert has also held senior executive positions in the environmental services, capital management and venture capital industries.Board InvolvementFranciscan Children's Hospital, Vice Chair, Board of TrusteesTeam Impact,  Member of National Board of DirectorsMassBio, Member, Board of DirectorsBA Sciences, Member, Board of DirectorsAnagram, Member, Board of DirectorsNuvara, Member, Board of DirectorsCystic Fibrosis Foundation, Chair, MA/RI Board of DirectorsSchwartz Center for Compassionate Care, Lifetime Board Member Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Thanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en

Note: This episode originally aired in September 2024. Are your dietary supplements third-party certified? John Travis, technical manager and spokesperson at NSF, an independent non-governmental organization dedicated to improving global health, joins the podcast to explain the different NSF certifications and why third-party testing matters for supplement safety. During this episode you'll learn about: What is NSF? An international not-for-profit organization that serves public health [0:54] What does NSF stand for? [5:11] The dietary supplement industry and the need for third-party testing [7:01] Certifications that NSF provides for dietary supplements: GMP, NSF Contents Certified, and NSF Certified for Sport® [10:12] NSF's requirements for certification: Annual audits and testing [11:51] How does NSF Certified for Sport® keep athletes safe? [19:08] What tests does NSF perform? [23:29] Questions from the community What's the difference between NSF and FDA? [28:32] What should coaches tell their athletes, especially young athletes, about supplement safety? [30:14] Why should nonathletes care about NSF Certified for Sport®? [32:54] How many tests or test methods does NSF perform? [36:18] Resources to topics mentioned in this episode: Got questions? Connect with John Travis via email at travis@nsf.org Learn more about NSF at NSF.org. Are you a professional athlete? Explore the ins and outs of NSF Certified for Sport® Taylor Hooton Foundation: Educating youth athletes and coaches about supplement safety What is NSF Certified? What Thorne's NSF Certifications Mean for You Thorne Supplements are 3rd-Party Contents Certified Unparalleled Quality: Thorne's Promise From Start to Finish Why the Best Supplements for Athletes Are NSF Certified for Sport® For Peak Performance, Start with a Strong Foundation How to Build a Supplement “Stack” for Athletic Performance How Thorne Supports U.S. National Teams and Their Athletes How to Build a Human Powered Health Routine What NSF Certified for Sport ® Means to Human Powered Health Cycling Athletes The Training Bundle: Best Supplements to Take While Working Out Manufactured by Thorne: Why You Should Know Who Makes Your Supplements From the podcast archives: Why NSF Certified for Sport® Supplements Are Important for All Athletes Products related to this episode: NSF Certified for Sport® Supplements Subscribe to More Content Subscribe to the show wherever you listen to podcasts so you never miss an episode. You can also learn more about the topics in the episode by checking out the latest news, videos, and stories on Thorne's Take 5 Daily blog.

In this episode of The Health Fix Podcast, Dr. Jannine Krause sits down with Jared St. Clair, an herbalist, supplement formulator, and host of the Vitality Radio Podcast. With over 30 years of experience running Vitality Nutrition, Jared is a leading expert on natural supplements and their role in hormone balance, digestion, immunity, and emotional wellness. Together, they break down how to read supplement labels, identify high-quality products, and avoid counterfeit supplements online. If you've ever felt overwhelmed by the supplement aisle, this episode is for you!

Today we're talking about methylene blue—aka the stuff that biohackers love, and journalists love to call "fish tank cleaner."  Discover how methylene blue functions as a redox cycling agent, enhancing mitochondrial function, supporting immune health, and even boosting mood.   What We discuss:  Focus on methylene blue and its benefits ... 00:04:33 Introduction to delivery systems and troches ... 00:09:00 Mitochondria's role in health ... 00:17:49 Methylene blue's impact on mitochondria ... 00:26:31 Dosage and its effects on different health issues ... 00:33:45 Cordycepin and immune support ... 00:50:39 GABAergic system and TroZ ... 01:00:59 Travel stack and recommendations ... 01:19:49 Closing thoughts and top tips for longevity ... 01:24:01   Our Amazing Sponsors: Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Whatever your health needs, there's a bioregulator for you. Head to profound-health.com and use code LONGEVITY15 for 15% off your first order.   LVLUP: The secret to CREvolution? It's all about GAA. This powerful compound helps you get more creatine into your cells faster than traditional creatine. Ready to crush your next workout? Head to lvluphealth.com and use the code NAT for 15% off.   BiOptimizers - Magnesium Breakthrough: It's the only full-spectrum magnesium supplement with 7 unique forms of magnesium that your body can actually use and absorb. Go to  bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Train with Matt: https://sweatelitecoaching.com/matt-fox/ Tune into the Private Podcast Feed and Join Our Discord Discussions:  https://www.sweatelite.co/shareholders/ Contact: matt@sweatelite.co Matt Instagram: https://www.instagram.com/mattinglisfox/ Matt Training Log - Strava: https://www.strava.com/athletes/6248359 In this 25th episode of the IMO on the Sweat Elite podcast, Matt shares updates about his recent experiences, including fascinating and challenging stories related to U.S. immigration and USCIS regulations. The episode covers various topics such as the journey towards obtaining a green card, dealing with unexpected delays and secondary screenings, and the decision to temporarily relocate to Japan and Europe due to visa issues. Plans for participating in the Osaka Marathon are also discussed, alongside a deep dive into the importance of running workouts, recovery strategies, and the potential benefits of substances like bicarb, creatine, and Ozempic. Additional segments include addressing listener questions, discussing the controversial Nick Bester situation, and speculating on the future performance of runner Shelby Houlihan post-doping ban. The host also makes a heartfelt appeal for support via their private podcast feed and community Discord channel. Topics: 00:00 Welcome to the Sweat Elite Podcast00:45 The Wild Immigration Story - Osaka Marathon18:58 Listener Comment: THC, CBD, and Pain Management22:15 Listener Question: Nick Bester Banned?31:01 Listener Question: BiCarb31:50 Listener Question: Training/Work Balance36:25 Listener Question: Recovery Supplements/Ratios41:49 Workouts Of The Week47:32 Controversial Topics: Ozempic and Shelby Houlihan59:07 Conclusion and Upcoming Plans WORKOUTS OF THE WEEK 5-10k: 5 or 6 x (1k @ 10km effort (1min) 500m @ 5k effort), R: 30sec/90sec. HM: 10k at HME, 2min rest, 2k @ goal pace M: 20k @ Marathon effort + 5k @ GMP inspired by Jake Barraclough      

In their latest AMA episode, Matt and Eti address listener questions ranging from "beauty sleep" to 3 AM awakenings. They explore the scientific evidence supporting sleep's crucial role in skin health and perceived attractiveness, citing studies on the effects of sleep deprivation. The cognitive benefits of napping are discussed, highlighting its ability to enhance learning and memory consolidation. They also delve into the remarkable neural activity of deep non-REM sleep, including synchronized neuron firing and accelerated memory replay. The common concern of sleep debt is also a key topic.The discussion then turns to practical strategies for managing disruptive midnight awakenings. Our hosts debunk common myths and explain the physiological factors involved, such as body temperature fluctuations and adenosine clearance. They provide evidence-based techniques to quiet the mind and promote a return to sleep, including controlled breathing, non-sleep deep rest, and cognitive approaches. Finally, they touch on the concept of "hypnopedia" (in-sleep learning), largely refuted by research, and the more promising technique of targeted memory reactivation, which uses sleep cues to enhance memory. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of protein. Ready to experience the Puori difference? Matt's listeners get 20% off, so visit puori.com/mattwalker today!Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.Another sponsor, 23andMe, provides genetic insights into health and sleep, and Matt, who has used it for eight years to understand genetic risks, is impressed by their sleep-focused data. With details on chronotype—whether you're genetically more inclined to be a morning person or night owl—along with insights on sleep quality, depth, and insomnia risk, 23andMe's reports offer valuable understanding of your unique sleep patterns. Explore your sleep genetics at 23andMe.com/MattWalker for 10% off your service.As always, if you have thoughts or feedback you'd like to share, please reach out to Matt or Eti:Matt: Instagram @drmattwalker, X @sleepdiplomat, YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/,  or email at etoosh@gmail.com

In his latest "Ask Me Anything" episode, Matt is once again joined by Dr. Eti Ben Simon to respond to a variety of audience questions, beginning with the role of AI in sleep medicine. Together, they explore how AI is currently being used to improve the accuracy and efficiency of sleep stage scoring, and how it shows promise in diagnosing sleep apnea and personalizing treatment plans. Matt highlights the potential for AI to integrate with smart home technology and predict an individual's risk of developing sleep disorders based on genetics, lifestyle, and environmental data. He also discusses the development of AI-driven therapeutic interventions like digital therapists and brain-computer interfaces to modulate sleep.Further responses touch upon the impact of sleep deprivation on ethical decision-making and the unique sleep challenges faced by astronauts in space. Matt and Dr. Ben Simon go on to consider the effects of disrupted circadian rhythms, microgravity, and CO2 buildup on astronauts' sleep quality. Finally, they engage in a playful thought experiment, each sharing their desired sleep superpower, ranging from sleep exchange to insightful dreams that provide instant solutions upon waking.Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of protein. Ready to experience the Puori difference? Matt's listeners get 20% off, so visit puori.com/mattwalker today!Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.Matt is only too happy to share the fact that launching his sleep-related merchandise sales was incredibly smooth, thanks to show sponsor Shopify and their integrated sales and inventory system. And now, just for you,  Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now! As always, if you have thoughts or feedback you'd like to share, please reach out to Matt on Instagram.Matt: Instagram @drmattwalker or on X @sleepdiplomatEti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/,  or email at etoosh@gmail.com