Podcasts about Penicillin

5.000 Einwohner, der Fluss Inn, Berge links wie rechts, Kreisverkehre, Supermärkte, die Autobahn A 12 - Kundl in Tirol lassen die meisten wohl links liegen auf ihrem Weg vom Norden in den Süden, von Deutschland etwa nach Italien, Kroatien oder die Schweiz. Dass der unscheinbare Ort aber seit 80 Jahren Leben rettet, ahnen wohl die wenigsten, die hier vorbeifahren. Denn in Kundl steht die mittlerweile letzte Fabrik in Europa, wo noch von Grund auf Penicillin hergestellt wird: vom Wirkstoff bis zur Tablette. Betrieben wird sie vom Basler Generikahersteller Sandoz. Doch der gerät zunehmend unter Druck: von Billigkonkurrenz aus Asien, besonders aus China, und den starren Vorgaben der EU-Gesundheitspolitik. Gast: Dieter Bachmann, NZZ-Wirtschaftsredaktor Host: Dominik Schottner Redaktion: Simon Schaffer Den ganzen Artikel könnt ihr [hier](https://www.nzz.ch/wirtschaft/alpenfestung-fuer-antibiotika-wie-eine-sandoz-fabrik-die-marktmacht-der-chinesen-spuert-ld.10008479) bei der NZZ lesen. Lust auf noch mehr digitale Inhalte der NZZ? [Probier`s drei Monate aus.](https://abo.nzz.ch/25077808-2/)

Group of antibiotic medications... Get cozy and relax! This podcast is funded by advertising. Info and offers from our sponsors: https://linktr.ee/EinschlafenMitPodcast Here's the Wikipedia article (revised): https://en.wikipedia.org/wiki/Penicillin Content was created or edited with the help of artificial intelligence. CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0/) Learn more about your ad choices. Visit megaphone.fm/adchoices

Good morning. After another tense night watching football in the pub, my friend reminded me of how different the experience is to when we were younger. How do you mean I asked. Well, we don't reek of smoke, he said. And I remembered what it used to be like. How after going to a gig, or a bar, everyone stank of someone else's smoke afterwards. And now we never do.It was twenty years ago this year that the Health Act passed, banning smoking in enclosed spaces… and today we take it for granted.Last month, almost under the radar, another law passed so that anyone born since January 2009 will never legally be able to buy tobacco products. Smoking will become rarer and rarer…but so gradually that we won't realise.We don't notice change as it's happening, it's absorbed into the new normal.If the morning news is immediate and dramatic, history is often incremental and invisible. It happens on the quiet.Until you stop to notice that it's hiding in plain sight. Or you measure it against a greater span than a news cycle. A life span, for example, a centurion like David Attenborough.Penicillin, discovered when Attenborough was two, has a reasonable claim to being the best invention since sliced bread… except that sliced bread was also invented in 1928.My uncle Dave, who died the other day, was the last of my mothers eleven siblings. One didn't survive into adulthood due to polio, a disease almost eradicated today. People no longer have 12 children like my grandparents, - the NHS, born when Attenborough was 22, introduced the contraceptive pill and family sizes fell.Then there's electrification or the mobile phone - when Attenborough was 50 … as well as, on the down side, the atom bomb and global warming.Just as we might wonder how our ancestors tolerated slavery or hanging maybe our descendants will wonder how we tolerated the industrial production of animals for food or tearing down rainforests. The American essayist Rebecca Solnit, who calls herself, in a winning phrase, an ‘ambient Buddhist,' says that it's not heroic leaders who change history but the seeds planted quietly by communities acting together… who may not live to see those seeds flower. Seeds of equality or justice or peace which, once planted, may seem to disappear. In her new book, The Beginning Comes After The End, Solnit calls these seeds ‘imaginal cells' which hold ‘the instructions for transformation'. Or as Jesus of Nazareth told his friends, ‘unless a grain of wheat falls into the earth and dies, it remains just a single grain; but if it dies, it bears much fruit.'

In this podcast episode... Penicillin has been around for almost 100 years, but its effectiveness against certain medical conditions is starting to fail. We catch up with a scientist whose team at UConn is looking for something better than pencillin in the war against resistant bacteria.

Paul Sloane joins James Smith to dismantle the myth of bad luck and reveal why the most successful innovations in history happened entirely by accident. A Cambridge engineer, former IBM marketer, and bestselling author, Sloane argues that what most people write off as misfortune is actually a hidden opportunity, and the people who notice it are the ones who change industries.

Episode: 3369 Small cells and microorganism that behave like living factories.  Today, tiny living factories.

Penicillin ist der vermutlich größte Lebensretter der Menschheit: das erste weithin wirksame Antibiotikum. Doch das war keineswegs so geplant. Der Mann, der es entdeckt, ist ein schüchterner, schottischer Bakteriologe, der vergessen hat, aufzuräumen: Alexander Fleming. Wir erzählen, wie aus seiner Zufallsentdeckung eine medizinische Revolution wird, warum es dreizehn Jahre dauert, bis der erste Patient mit dem Medikament behandelt wird und warum Fleming bei dieser Geschichte oft nur Nebendarsteller ist. Denn der Fortschritt verläuft häufig weniger geradlinig, als wir glauben.Du hast Feedback oder einen Themenvorschlag für Joachim und Nils? Dann melde dich gerne bei Instagram: @wasbishergeschah.podcastQuellen:Brown, Kevin: Penicillin Man: Alexander Fleming and the Antibiotic Revolution, London 2005Lax, Eric: The Mold in Dr. Florey's Coat: The Story of Penicillin and the Modern Age of Medical Miracles, New York 2004Hoffmann, Siegbert: Penicillin: Ein Zufall, der die Medizin veränderte. Von der Entdeckung durch Alexander Fleming bis zur Revolution der Antibiotika, Berlin 2024Alexander Fleming (1881–1955): Discoverer of penicillin. Singapore Med J, 2015 Jul; 56(7): 366–367 2025Doku: The Discovery of Penicillin 1964Wainwright, Milton: Hitler's Penicillin. In: Perspectives in Biology and Medicine, 47(2), S. 189–198 2004https://www.nobelprize.org/uploads/2018/06/fleming-lecture.pdfRKI: https://www.rki.de/DE/Themen/Infektionskrankheiten/Antibiotikaresistenz/Grundwissen/grundwissen-antibiotikaresistenz-node.htmltagesschau: https://www.tagesschau.de – Warnung der WHO: Immer mehr Antibiotika wirken nicht mehr++ Buchtipp des Monats ++Die verdammt blutige Geschichte der Antike, wie sie wirklich war: Hier gehts zum Buch++ Podcast-Tipp ++Riefenstahl - Influencerin des Bösen, jetzt hören in ARD Sounds. Hier gehts zum Podcast. Hosted on Acast. See acast.com/privacy for more information.

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Selena: Hi doctor Cabral, I'm looking for some insight into my body composition. I'm a 47-year-old female currently strength training 6 days/week (30-min Upper/Lower split) and averaging 20K steps daily. My intake is ~2200 kcal (150-180g Protein / 200g Carbs). While I'm lean and can feel the muscle underneath, I'm lacking visible definition. Am I potentially over-training, or do I need to adjust my intensity/recovery to see better hypertrophy? Thanks so much in advance for your answer!      Jen: Any advice! Sick w/something middle of December (maybe subclade K as it was the week that was apparently the pinnacle week in UK) , GP prescribed Penicillin as sent a pic of throat & he said maybe Strep. Didn't work so Clarathromycin which made me better but then Oral Thrush which went on weeks treated with Daktarin/Fluconazole (had to beg for it) but had 3 ever increasing doses. Now I have been told it's Burning Mouth Syndrome. Tested for Full Bloods, Diabetes & even HIV (all normal or Negative for the latter). This has been 2.5 months of hell. Saw a Oral Maxillofacial specialist on Friday who said I needed to brush HARD TOOTHBRUSH with Kingfisher (Inc Sodium Lauroul Sarconsinate) & that I'm just having Menopause! I lost my @#*& ! Bloods due for Vits/Mins. Taking vit A-Z , alpha Lapoic.      Mohamed: Hello Dr.Cabral. I enjoy watching your weekend house calls and your in-depth responses are fantastic. My question is 2 part.. if you could do 3-4 things to support healthy blood pressure (Dad's on higher side, 160/80s). What would the 4 things be? For a late 60s man. 2nd question is regarding Intracellular nutrient analysis lab? It states " The INA (Intracellular Nutrient Analysis) directly measures the effect of specific micronutrients on the ability of T and B lymphocytes to reproduce when stimulated with a mitogen (i.e., mitosis generator)". Thoughts on this? Thanks!        Maria: Dr. Cabral, thank you for all you do for everyone. Your amazing! Can you talk a little bit about hammer toe, curl toes, etc Is this curable. I didn't find anything in your podcast. again thank! Have an amazing blessed day.      Sonny: Hi Dr. Cabral, thank you for everything you do. I'm an IHP2 and had a question about my morning routine. I wake at 4:45am and do tongue scraping, oil pulling, meditation, breathwork, and drink ~500ml lemon water with sea salt. I strength train from 6:00am–7:00am (about 30 min mobility + 30 min strength), then walk outside 35–40 minutes, followed by ~25 minutes in an infrared sauna and a shower. By then it's around 9am and I'm still fasted. I usually finish dinner around 6–6:30pm, so it's a long overnight fast. As a Vata body type, is this too long given the morning activity? Would drinking my protein smoothie around 8am during the sauna blunt the sauna benefits? Also, would drinking essential amino acids before my workout be helpful, or would that break the overnight fast?      Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3718 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

A study led by Melbourne’s Austin Hospital is transforming how doctors' approach one of the world's most common medical labels - the penicillin allergy.See omnystudio.com/listener for privacy information.

A 360-second podcast that's full of the weird, the wonderful, the profound and the hilarious facts of life on earth.© 2026 Jonathan Clemson & Robin Crossman

Send a textDay-one decisions shape a newborn's first week, and small changes can prevent big problems. In this episode, Cara and Missi dig into what's truly evidence-based now—delayed bathing to protect vernix and temperature, uninterrupted skin-to-skin to reduce energy burn, and clear thresholds for when to check and treat low blood sugar. Along the way, we unpack how updated NRP guidance simplifies early care: extend cord clamping to at least 60 seconds when possible, start term babies on room air, broaden ventilation rates to 30–60 per minute, and skip routine suctioning unless the airway needs clearing. Less fuss means warmer babies, steadier vitals, and fewer glucose crashes.Cara and Missi clear the fog around GBS prophylaxis. Penicillin remains the standard, with cefazolin for low-risk penicillin allergy and vancomycin when high-risk reactions are present or clindamycin sensitivity isn't confirmed. That clarity matters for maternal safety and newborn outcomes, especially in units where ampicillin lingers from past shortages. If your patients report a penicillin allergy early in pregnancy, consider formal evaluation to avoid unnecessary second-line antibiotics later.Finally, we connect physiology to practice. Newborns lose the maternal glucose “buffet” at birth and lean on glycogen and brown fat to bridge the gap; cold stress accelerates that burn, making hypothermia and hypoglycemia frequent partners. We outline who needs screening—IDMs, SGA, LGA, late preterm, and resuscitated infants—and how to manage lows with a calm, stepwise approach: warm the baby, feed early and often, use donor milk or glucose gel when indicated, and escalate to IV dextrose for symptomatic cases. It's a practical, exam-friendly, and family-centered guide to safer newborn care. #Baby #Newborn #BabyBabyAreYouOkay #Resuscitation #EatingAtThePlacentaBuffet #BloodSugar #NRP #SkinToSkin #GBSProphylaxis 

Send a textDay-one decisions shape a newborn's first week, and small changes can prevent big problems. In this episode, Cara and Missi dig into what's truly evidence-based now—delayed bathing to protect vernix and temperature, uninterrupted skin-to-skin to reduce energy burn, and clear thresholds for when to check and treat low blood sugar. Along the way, we unpack how updated NRP guidance simplifies early care: extend cord clamping to at least 60 seconds when possible, start term babies on room air, broaden ventilation rates to 30–60 per minute, and skip routine suctioning unless the airway needs clearing. Less fuss means warmer babies, steadier vitals, and fewer glucose crashes.Cara and Missi clear the fog around GBS prophylaxis. Penicillin remains the standard, with cefazolin for low-risk penicillin allergy and vancomycin when high-risk reactions are present or clindamycin sensitivity isn't confirmed. That clarity matters for maternal safety and newborn outcomes, especially in units where ampicillin lingers from past shortages. If your patients report a penicillin allergy early in pregnancy, consider formal evaluation to avoid unnecessary second-line antibiotics later.Finally, we connect physiology to practice. Newborns lose the maternal glucose “buffet” at birth and lean on glycogen and brown fat to bridge the gap; cold stress accelerates that burn, making hypothermia and hypoglycemia frequent partners. We outline who needs screening—IDMs, SGA, LGA, late preterm, and resuscitated infants—and how to manage lows with a calm, stepwise approach: warm the baby, feed early and often, use donor milk or glucose gel when indicated, and escalate to IV dextrose for symptomatic cases. It's a practical, exam-friendly, and family-centered guide to safer newborn care. #Baby #Newborn #BabyBabyAreYouOkay #Resuscitation #EatingAtThePlacentaBuffet #BloodSugar #NRP #SkinToSkin #GBSProphylaxis 

Last week on Fox News Greg Gutfeld, Jesse Watters and other overpaid Fox News personalities proved there is no limit to the depravity and hypocrisy on the Murdoch owned media empire. The network seemed desperate to focus on the Nancy Guthrie abduction rather than talk about anything that might make its glorious leader, an increasingly demented cruel sociopath, look bad.Gutfeld made dismissive jokes about Nancy Guthrie, an ailing 85-year-old grandmother who was abducted from her home outside of Tucson, Arizona. Two horrifying pieces of evidence in the case include a video of a masked man approaching her front door in the middle of the night and a trail of the elderly woman's blood scattered across her entryway.The diminutive perpetually angry Gutfeld! host appeared annoyed that his employer was spending so much time on the story so he lashed out at his own network like a spoiled child.Jesse Watters joked that Jeffrey Epstein was some type of fixer who helped rich and powerful men ‘get a girl.' He could have easily substituted the word woman for girl but chose to make light of the sexual abuse of children.His co-host Kennedy joked Epstein's associates might need some penicillin presumably for sexually transmitted diseases. Never mind the abuse of children who were smuggled to Epstein's island from overseas or led to his compound under false pretenses.Some of Epstein's victims have committed suicide. A U.N. panel found Epstein could have been running a global criminal enterprise that included crimes against humanity.The hundreds of child sex trafficking victims were reduced to an inconvenience for their older and much more powerful abusers. This is after months when Watters spent more time than anyone else on Fox News condemning Epstein for his crimes. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit decodingfoxnews.substack.com/subscribe

We've all seen it: the patient whose chart is “flagged” with a penicillin allergy, but when you dig into the history, the story doesn’t quite add up. Maybe it was a stomach ache in the 90s, or maybe they're just carrying a “inherited” allergy from a parent. In this episode of EM Pulse, we sit down with ED Clinical Pharmacist Haley Burhans to discuss why these labels are more than just a nuisance—they're a clinical liability—and how a simple tool can empower you to fix them on the fly. The Hidden Danger of the “Safe” Choice Choosing a non-beta-lactam antibiotic because of a questionable allergy label feels like the path of least resistance, but the data tells a different story. We explore how “playing it safe” can actually lead to: Worse Outcomes: Why second line antibiotics often mean higher treatment failure rates. The “Superbug” Factor: The surprising link between penicillin allergy labels and the rise of MRSA and VRE in our communities. The C. diff Connection: Why alternative choices might be setting your patient up for a much more difficult recovery. The Solution: The PEN-FAST Score How do you move from “I think this might not be a true allergy” to “I am confident this antibiotic is safe”? Haley introduces the PEN-FAST score, a validated scoring tool designed to risk-stratify patients based on a few key historical questions. The Mnemonic: We break down the PEN-FAST acronym so you know exactly which three questions to ask to risk-stratify your patient in seconds. IgE vs. The Rest: Learn to distinguish between the “true” dangerous hypersensitivity and the delayed reactions that shouldn’t stop you from using the best drug for the job. The “Amoxicillin Rash”: We dive into this common pediatric “gotcha.”, why many kids end up with a lifelong allergy label after a routine ear infection, and why it often has nothing to do with the drug itself. The Bottom Line: Patients with low PEN-FAST scores are considered low risk, making an oral challenge under observation in the ED a reasonable option. Higher scores may require shared decision-making or referral. Why the ED is the Perfect Place for a “Challenge” Delabeling isn’t just for the allergist’s office. We argue that the Emergency Department is actually the ideal setting to challenge these allergies. The “Oral Challenge”: Learn the practical steps for performing a trial dose in the department. Safety First: Why your environment and expertise make you uniquely qualified to handle the “what-ifs” better than anyone else. Key Takeaways Question the Label: The vast majority of reported penicillin allergies are inaccurate due to patients outgrowing the allergy or misinterpreting common side effects as allergic reactions. History is Everything: Dig deeper than just “rash.” Ask about the timing relative to the dose, specific appearance (hives vs. flat rash), and what treatment was required (epinephrine vs. antihistamines). Use PEN-FAST: Utilize this tool to objectify the risk. Document Tolerance: Even if you don’t fully delete the allergy label, if you successfully treat the patient with another beta-lactam (like ceftriaxone), document that tolerance clearly to aid future clinicians. Cephalosporins are likely safe: Later-generation cephalosporins generally have very low cross-reactivity and are usually safe options even in truly allergic patients How do you handle documented penicillin allergies? Do you use the PEN-FAST tool? Share your experience with us on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Professor of Emergency Medicine at UC Davis Guests: Haley Burhans, PharmD, Emergency Medicine Clinical Pharmacist at UC Davis Resources: PEN-FAST Score on MDCalc Penicillin Allergy Evaluation Should Be Performed Proactively in Patients with a Penicillin Allergy Label – A Position Statement of the American Academy of Allergy, Asthma & Immunology Staicu ML, Vyles D, Shenoy ES, Stone CA, Banks T, Alvarez KS, Blumenthal KG. Penicillin Allergy Delabeling: A Multidisciplinary Opportunity. J Allergy Clin Immunol Pract. 2020 Oct;8(9):2858-2868.e16. doi: 10.1016/j.jaip.2020.04.059. PMID: 33039010; PMCID: PMC8019188. Yang C, Graham JK, Vyles D, Leonard J, Agbim C, Mistry RD. Parental perspective on penicillin allergy delabeling in a pediatric emergency department. Ann Allergy Asthma Immunol. 2023 Jul;131(1):82-88. doi: 10.1016/j.anai.2023.03.023. Epub 2023 Mar 27. PMID: 36990206. *** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.  

National plumb pudding day. Entertainment from 2007. 1st use of penicillin, 1st spacecraft to land on an asteroid, Lincoln penny went into circulation, largest sailfish ever caught. Todays birthdays - Abraham Lincoln, Lorne Greene, Moe Bandy, Maud Adams, Michael McDonald, Joanna Kerns, Arsenio Hall, Chynna Phillips, Josh Brolin, Christina Ricci. Tom Landry died.Intro - God did good - Dianna Corcoran  Dianna on SpotifyPlumb pudding - The ArchiesIrreplaceable - BeyonceWatching you - Rodney AtkinsBirthdays - In da club - 50 Cent     http://50cent.com/Ringo - Lorne GreeneShes not really cheatin (shes just gettin even) - Moe BandyI keep forgettin - Michael McDonaldArsinio Hall in Coming to AmericaHold on - Wilson PhillipsExit - Cowgirl - Buck Ford   https://www.buckford.com/ countryundergroundradio.comHistory & Factoids about today webpagecooolmedia.com

Vor 85 Jahren wurde erstmals Penicillin verabreicht - ein Meilenstein der Medizin. Viele Krankheitserreger sind inzwischen aber resistent gegen Antibiotika. Der Infektiologe Lübbert warnt vor einem schleichenden Sterben.

Matt Roeske, the master of rabbit holes, is back for our third interview and as usual, this one does not disappoint.One of my goals is to encourage everyone to rethink what they already know (I put myself in that target audience) and Matt is definitely one to cause us to do just that.Many of us are seeing that what we have been told about pretty much everything is either a flat out lie or twisted in some regard. In this mind-expanding conversation, Matt once again challenges conventional wisdom on every level—from eating raw meat to understanding the real value of silver, from mouldy berries that heal to the suppressed knowledge of a man who cured himself of C in the 1970s.We also learn of the fascinating tree resin, Dragon's Blood. Truly one of mother nature's healers.Whether you're ready to question the food pyramid, rethink precious metals, or discover why your grandparents knew more about health than modern doctors, this conversation will shake your assumptions and offer practical solutions for true independence in 2026 and beyond.In today's show:5:11 - Silver at $90/ounce, highest ever, expected to keep rising due to Federal Reserve money printing6:35 - 2026 mirrors 1890s McKinley Tariffs playbook: tariffs, farmers struggling, precious metals surging - Trump quoted McKinley as inspiration10:17 - Asia blocked silver trade agreements, creating scarcity - bullion stores sold out everywhere11:30 - Germany's currency 1933-1950s was silver after hyperinflation destroyed paper money13:36 - Copper penny eliminated a month ago because copper value exceeded penny's face value16:05 - Matt's raw diet for 11-12 months: raw meat, raw milk, raw honey18:18 - How Matt's new diet activated his super smelling sense19:15 - Chemtrails deployed most heavily during full moons20:30 - Mouldy berries pull heavy metals from body21:01 - Aajonus Vonderplanitz healed afflictions with raw diet in 1970s-80s23:43 - Vonderplanitz said viruses are fake, parasites don't harm in 1980s-90s30:30 - The mysterious stories around Aajonus's death one year after Doctor's show appearance39:38 - Dr. Pottenger study: 900 cats on raw meat/milk became lions, cats on processed food became disabled and infertile44:10 - Pork and nitric oxide content and how Viagra replaced it46:51 - 5,000 PubMed studies show parasites grow in animals to eat heavy metals, not contagious51:10 - Mouldy berries create trippy, mushroom-like detox effect51:30 - Grandmothers traditionally added mouldy berries to soup, applesauce, raw milk for health52:30 - Penicillin shots as children and allergies to natural mould54:25 - Mouldy blueberries and heavy metals60:30 - Dragon's blood and severe eczema head-to-toe, receding gums60:50 - Dentists reported patients' gums regenerating with coconut oil and dragon's blood61:05 - Testimonial: arthritis inflammation 99% gone with four dragon's blood capsules daily64:07 - Electro culture book coming spring 2026 proving no scarcity exists65:43 - AI clones of Matt's voice/image scamming people, DO NOT purchase from these fake companies!and more!If you enjoyed this episode, please share if you dare and consider going to www.sovereigncollective.org/shop to check out my offerings and get a deal while supporting the podcast. I'll be adding more great offerings there over time.Matt is highly censored, so you'll have a hard time finding him on the major mainstream channels, or you'll have to look hard to find him.Peruse his site and use code Sascha10 to save on some goodies including Dragon's Blood:https://cultivateelevate.com/Matt posts on various platforms and does a regular live every week on Monday, among other videos and posts. Find him here:https://rumble.com/user/CultivateElevatehttps://odysee.com/@CultivateElevate:e2telegram: @ElevateThyMindhttps://www.instagram.com/cultivateelevate/--------------------------------------------Find me:Facebook: https://www.facebook.com/saschakalivoda/IG: https://www.instagram.com/saschaksays/Website: www.sovereigncollective.orgYou Tube: https://www.youtube.com/@saschasays/videosBitchute: https://www.bitchute.com/channel/Tfl1Zo021FcXEmail: sascha @ sovereigncollective.org

It regulates 20 percent of the U.S. economy, and its commissioner has an aggressive agenda — faster drug approvals, healthier food, cures for diabetes and cancer. How much can he deliver? (Part two of “The Freakonomics Radio Guide to Getting Better.”) SOURCES:Marty Makary, commissioner of the Food and Drug Administration. RESOURCES:"Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health," by Vishal Patel, Michael Liu, and Anupam Jena (JAMA Internal Medicine, 2025)."What the evidence tells us about Tylenol, leucovorin, and autism," by Matthew Herper (STAT, 2025)."I Run the F.D.A. Pharma Ads Are Hurting Americans." by Marty Makary (New York Times, 2025).Blind Spots: When Medicine Gets It Wrong, and What It Means for Our Health, by Marty Makary (2024). EXTRAS:"Are You Really Allergic to Penicillin?" by Freakonomics Radio (2025)."How to Fix the Hot Mess of U.S. Healthcare," by Freakonomics Radio (2021)."Bad Medicine, Part 3: Death by Diagnosis," by Freakonomics Radio (2016). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This week we're heading to the gritty streets of Edinburgh for the visceral, high-octane 1996 masterpiece, Trainspotting! We're choosing life, choosing a job, and choosing to dive deep into Danny Boyle's groundbreaking look at Renton and his circle of friends. We'll discuss the iconic "Choose Life" opening, the pulse-pounding Britpop soundtrack, and how the film balances dark, surreal humor with the harsh realities of addiction and friendship.Since the characters in Trainspotting are often looking for a "fix" or a way to numb the world around them, we're serving up a drink that feels like a bit of a medicinal miracle: The Penicillin. This modern classic is the perfect tribute to the film's Scottish roots, featuring a base of Blended Scotch Whisky shaken with Fresh Lemon Juice and a spicy-sweet Honey-Ginger Syrup.So, grab your glasses and get ready to raise a glass to Trainspotting!Cocktail inspiration comes from Cinema Sips!!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merch Shop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drinkthemovies.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠*Please Drink Responsibly*

AKA Penicillin Allergy 3: Delabel Hard With A VengeanceA departure from our semi-annual penicillin allergy episode: one on cephalosporin allergy! Jame and Callum are joined by Fionnuala Cox to discuss Cephalosporin allergy in general, and the CEPH-FAST risk assessment tool in particular. Ever wanted to know how to deal with cephalosporin allergy? Listen on! Paper here: Cox F, Vogrin S, Sullivan RP, Stone C, Koo G, Phillips E, et al. Development and validation of a cephalosporin allergy clinical decision rule. Journal of Infection. 2025 June 1;90(6). Available from: https://www.journalofinfection.com/article/S0163-4453(25)00089-1/fulltexthttps://doi.org/10.1016/j.jinf.2025.106495(It's open access, don't worry) Audience survey: Tell us how rubbish we are here!  Sign up for the BIA Dilemmas Day on Critical Care Infections here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

When should an antibiotic allergy actually be tested? In this episode of the BackTable ENT Podcast, guest host Dr. Basil Kahwash, an allergist and immunologist at Ohio ENT & Allergy, sits down with Dr. Cosby Stone, an allergist and immunologist at Vanderbilt University Medical Center, to discuss antibiotic allergies and how to distinguish true allergies from intolerances. --- SYNPOSIS Dr. Stone breaks down common misconceptions around antibiotic allergies, with a focus on penicillin and cephalosporins. The conversation explores how these allergies are evaluated, including when skin testing is appropriate, why inaccurate allergy labels matter, and how confirmed allergies should be managed long term. They also dive into more advanced topics such as drug desensitization, current research in the field, and where the future of drug allergy evaluation is headed. --- TIMESTAMPS 00:00 - Introduction 01:03 - Understanding Antibiotic Allergies07:28 - The Importance of Accurate Allergy Diagnosis10:55 - Key Questions for Diagnosing Allergies17:10 - Implementing Allergy Testing in Healthcare Settings19:06 - Identifying Severe Allergic Reactions26:31 - Interpreting Allergy Skin Testing Procedures33:17 - Penicillin and Cephalosporin Cross-Reactivity37:15 - Drug Desensitization: Indications and Process40:30 - Prognosis and Long-Term Outcomes of Drug Allergies47:22 - Conclusion and Final Thoughts --- RESOURCES Dr. Basil Kahwash https://www.ohioentandallergy.com/physicians/basil-kahwash-md/ Dr. Cosby Stonehttps://www.vanderbilthealth.com/doctors/stone-cosby

If you've got a penicillin allergy, this episode is crucial for you! That's because you can outgrow a drug allergy like this even if you developed it as an adult. Antibiotic allergies are either misdiagnosed or fade over time. Even if you avoid taking antibiotics like the plague, having a drug allergy on your medical chart can end up limiting treatment options if you find yourself truly needing them.In this episode, my guest, Dr. Mariana Castells, breaks down how drug allergies are diagnosed, how long they take to disappear, why they can appear later in life, and how “drug delabeling” could dramatically improve your care (especially when something serious happens). Dr. Mariana Castells, M.D., Ph.D., is a world-renowned expert in allergy and immunology with over 30 years of experience. Whether you have an antibiotic allergy (or you know someone who does), this is a must-listen interview!⭐️Mentioned in This Episode:- See all the references

Here's one for you: which relatively niche sport may be responsible for one of the greatest scientific discoveries in human history? Off The Ball's Cameron Hill can reveal all.

Dr. Edmund Tsui interviews Dr. Brian C. Toy on his retrospective cohort study which shows that oral doxycycline clinical and serologic outcomes are comparable to IV penicillin for syphilitic uveitis, published in Ophthalmology. From "Outpatient Oral Doxycycline versus Intravenous Penicillin for Syphilitic Uveitis." Outpatient Oral Doxycycline versus Intravenous Penicillin for Syphilitic Uveitis. Bao, Yicheng K. et al. Ophthalmology, Volume 132, Issue 12, 1457 - 1459.

Hello to you listening in Sayville, New York!Coming to you from Whidbey Island, Washington this is Stories From Women Who Walk with 60 Seconds for Motivate Your Monday and your host, Diane Wyzga.The other day I was talking with my longtime friends, colleagues and brainstormers, Tania and Leanne, about times when we set out to achieve X but an unintended, better-than-expected Y happened. You know what I mean: the mystery of unintended consequences that turns out to be amazing!Here's one: The Scottish biologist Alexander Fleming  was working on a project on Staphylococcus bacteria at St. Mary's Hospital in London. He took off on vacation leaving behind an uncovered petri dish of bacteria. When he returned he saw a blue-green mold (like what you might find growing on bread exposed to moisture) growing on the dish and that the Staph bacteria were being killed in the area of the mold. Fleming - knowing a good thing when he saw one - identified the mold as the fungus penicillin notatum, and Shazaam! developed penicillin as an antibiotic. Fleming's unintended discovery of penicillin revolutionized the treatment of infections.Click HERE to learn more about the Discovery and Development of Penicillin 1928-1945Now, as to the moldy bread in your kitchen. Yes, penicillin is an antibiotic produced by a fungus called Penicillium notatum. Yes, this fungus is commonly found on moldy bread. Yes, when the fungus grows on bread, it releases penicillin into the surrounding environment.Let me caution you! Not all moldy bread contains penicillin. Moreover, eating moldy bread is a very big “No! No!” as it can contain harmful substances. Having said that think twice before you toss out what might be an unintended answer to a problem.  Question: When did you set out to achieve X but an unintended Y turned out to be what you were looking for?  What happened next?You're always welcome: "Come for the stories - Stay for the magic!" Speaking of magic, I hope you'll subscribe, share a 5-star rating and nice review on your social media or podcast channel of choice, bring your friends and rellies, and join us! You will have wonderful company as we continue to walk our lives together. Be sure to stop by my Quarter Moon Story Arts website, check out the Communication Services, arrange a no-obligation Discovery Call, and stay current with me as "Wyzga on Words" on Substack.Stories From Women Who Walk Production TeamPodcaster: Diane F Wyzga & Quarter Moon Story ArtsMusic: Mer's Waltz from Crossing the Waters by Steve Schuch & Night Heron MusicALL content and image © 2019 to Present Quarter Moon Story Arts. All rights reserved.  If you found this podcast episode helpful, please consider sharing and attributing it to Diane Wyzga of Stories From Women Who Walk podcast with a link back to the original source.

Join Dr. Nicholas Cline and host Marcella Feathers as they discuss the reintroduction of the Penicillin Allergy Verification and Evaluation (PAVE) Act.  The PAVE Act would require physicians to verify a penicillin allergy during the "Welcome to Medicare" preventive visit and annual Medicare wellness visits.  Penicillin was discovered in 1928 by Alexander Fleming and is an inexpensive but very effective antibiotic. Dr. Cline shares why the majority of patients who believe they're allergic to penicillin may have an inaccurate diagnosis and what options are available for determining if an allergy actually exists. Whether or not you're a Medicare patient, confirming a penicillin allergy can save you money and time!

Featuring Chris Fowlie recapping the week just been of weed in the news on Marijuana Media, thanks to The Hemp Store. Later in the show Mat concotes a delicious Penicillin with a Tommy twist on Cocktail Corner, thanks to Thomson Whiskey.  Brought to you by The Beer Spot!

Episode Highlights With CarolynYeast is normal, yeast overgrowth is notWhat to know about yeast The introduction of penicillin and how this affected yeast How yeast can turn into a mycelial yeast that pokes holes in the small intestineYeast produces 78 known toxins in the body It's possible to have enough yeast overgrowth that produces alcohol byproducts that it will make a person fail a breathalyzer test How dentistry comes into play and common dental things used contribute to yeast overgrowthThe difference between SIBO and yeast overgrowth and why yeast is almost always present if there is How hormones come into play and why magnesium is so importantThe lesser known symptoms of yeast and why things like rashes can be a good signThe thyroid, yeast, and magnesium connection and how supporting magnesium and managing yeast can improve thyroid healthHow hormones, including birth control pills, can lead to yeast overgrowth Unique protocols for supporting the body in beating yeast overgrowth and getting back into balanceThe immune system is so affected by yeast that with yeast overgrowth it's easy to develop other infections and conditionsHow parasites come into play and why fixing yeast also helps the body eliminate parasitesHer protocol for addressing yeast without stressing the body outImportance of food based vitamin C and ascorbic acid Yeast overgrowth and mineral deficiency are directly related to autoimmune disease and she explains how!Resources MentionedRnA ReSetPico Silver supplementFlora Revive supplementThe Yeast Connection - book

In this podcast accompanying the November issue of DTB (https://dtb.bmj.com/content/63/11) David Phizackerley (DTB Editor) is joined by Syba Sunny (DTB Clinical Editor). David and Syba discuss the editorial that argues that NHS budgets should not be used to ensure that pharmaceutical companies invest in the UK (https://dtb.bmj.com/content/63/11/162). They talk about a DTB Select article that summarises a systematic review and meta-analysis of trials that assessed patients with a reported penicillin or beta-lactam allergy who underwent direct oral penicillin challenge (https://dtb.bmj.com/content/63/11/163). They finish by discussing the main article that explores the intersection of medication errors, prescribing errors, harms resulting from the use of medicines and some legal consequences (https://dtb.bmj.com/content/63/11/168).   Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page. If you want to contact us please email dtb@bmj.com. Thank you for listening.

This week in a special Lobby Bar Classic, we mix up a new classic - The Penicillin and talk about pairing it with a modern classic film!Have you tried the Penicillin?⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merch Shop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drinkthemovies.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠*Please Drink Responsibly*

Matters Microbial #112: Bacterial Size, Stress, and Antibiotic Resistance October 17, 2025 Today Dr. Petra Levin, the George and Irene Freiberg Professor of Biology at Washington University in St. Louis joins the #QualityQuorum to discuss her work with bacterial cell size, environmental stress on bacteria, and antibiotic resistance. Host: Mark O. Martin Guest: Petra Levin Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An overview of the periplasm, found in Gram negative bacteria. An overview of beta-lactam antibiotics. The field of quantitative microbiology. An overview of B. subtilis.  An overview of E. coli.  An overview of Klebsiella.  The biography of Barbara McClintock, “A Feeling for the Organism.” A video explanation of the lac operon of E. coli. The LTEE program (Long Term Evolution Experiment) founded by Dr. Rich Lenski. The nomenclature of monoderm and diderm bacteria. A video explanation of peptidoglycan in bacteria. Penicillin binding proteins (PBP) and antibiotic resistance. A video about cell division in E. coli. A famous article coauthored by Dr. Elio Schaechter that describes cell growth and cell size in bacteria. A related article by Dr. Levin and colleagues. An overview of ESKAPE bacteria. An article from Dr. Levin's research group describing the relationship between pH and antibiotic resistance. An article about persister cells and their relevance to antibiotic resistance. Dr. Levin's faculty website. Dr. Levin's very interesting laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog If you ever doubted your doctor because she wrote a script that you later “Googled” and found was not FDA approved, I hope you trusted your doctor enough to realize that she wouldn't recommend any medication that would hurt you…. What is an unapproved use of a drug, also called “off-label”? Unapproved use of an approved drug is often called “off-label” use. This term can mean that the drug is: Used for a disease or medical condition that it is not approved to treat, such as when a chemotherapy is approved to treat one type of cancer, but healthcare providers use it to treat a different type of cancer. The drugs that are not approved by the FDA, yet are commonly used, have been used for decades before the 1964 law that required new drugs to go through extensive and very expensive testing before their release to the public. The operative word is NEW DRUGS AFTER 1964. Today I will talk about the safety of non-FDA approved drugs because they are: Older cheaper drugs used for many diseases and conditions before 1964 and are still used Drugs that are approved for one use, or one condition, but not for other conditions that it is effective and safe for. Drugs made by compounding pharmacies for diseases that the FDA has not approved a drug for, but there is research backing the drug and years of safe use. First, before we discuss the non-FDA approved drugs, I will discuss the safety/risks of FDA approved drugs, and why FDA approval doesn't mean a drug will do no harm or even that it is effective for the use it is approved for. A little background will help you understand the problem and the reason an FDA approval does not necessarily mean a drug is safe.  Since 1964, a law was passed that established testing prior to a drug being approved by the FDA became mandatory.   Since that time several drugs that survive FDA approval and are released but are later removed or banned after their FDA release when the public finds side effects that the FDA didn't discover in their trials. One such drug is Fen-Phen, Fenfluramine/Phentermine. This drug was released during my time practicing medicine and was withdrawn after one study claimed it caused heart valve disease…In the end the “one post approval study” that claimed that heart valves were affected by this drug that caused its bann was found to be false. The withdrawal of the drug followed one study by a single cardiologist from Kansas City had reviewed all of the cardiac valve echo tests and falsified the results to make Fen-Phen appear dangerous to heart valves, when in reality it wasn't.  She lost her license, but the FDA never put Fen-Phen back on the market!  The FDA hates to be wrong twice, so they never allowed this drug back on the market after its removal. Other mistakes made by the FDA include not allowing women in the studies to approve a drug before 2014 which ignores or misses all of the side effects or lack of effectiveness for a drug when taken by women.  Despite all the expensive testing before the release of a drug by the FDA, many drugs not tested on women were later often found to have severe side effects only on women. A few examples follow: You might have heard of the FDA approved drug Ambien that causes many women to experience “night eating”, sleepwalking, and night terrors, while their male counterparts were not affected, so because they only tested men the drug was approved. In retrospect it should have been tested on women as well, and then either not passed through the FDA or should have had a black box warning for women. It takes years get action from the FDA, notifying doctors of these side effects. Women were not included in testing for any drugs except female hormones until 11 years ago, but no other drugs.   Before 2014 all (non-hormonal) drugs that passed the FDA were not tested on women so the effect on women was unknown until it was tested on the public. The FDA left women out of drug-trials because it viewed women as “mini men”, or they didn't consider us important enough to test new drugs on…OR worse, they believed we were too complicated to easily test us because of pregnancy, menopause and other hormonal swings that normal healthy women have.  In any case, we are now suffering their decisions, when a medication works one way for men and another way for women! Finally, we are tested when drugs are being evaluated for approval by the FDA. Professional women have achieved a level of authority in medicine and pharmacology (2025) and are weighing in on the inequity. Women in the medical profession and the public are pulling back the curtain on the side effects of FDA approved drugs that are experienced by women only! Slowly, study by study investigators are now publishing the side effects and problems for women with FDA approved drugs….yet these findings are not included in the warnings on most of these drugs, even now over 15 year after they became obvious to the doctors who treat women! Drugs that either don't work for women, or that have severe side effects include that were approved before 2014. All statin drugs for high cholesterol (Crestor, rosuvastatin, atorvastatin, etc.) cause women to have muscle breakdown and muscle pain. Synthroid (levothyroxine), doesn't cure the symptoms of hypothyroidism in 80% of women, but just makes the TSH lower, so it appears as if it is working! This leads doctors to tell women that their symptoms are all in their heads!! Wrong.  It is the wrong medicine. Women have enzymes that differ from men that make it difficult for them to convert the inactive form (T4) into the active form (T3), so we can't convert Synthroid (all T4) into the active form. Synthroid, the FDA approved drug for hypothyroidism, shouldn't be given to most women. Women should be given the non-FDA approved drug Armour Thyroid or NP thyroid that have both T3 and T4 in them! Ambien Prednisone and other oral steroids We have reviewed the lack of testing on women before 2014, now we will discuss safe drugs that have been used for decades even before 1964 when the FDA required testing for FDA approval? Older, yet effective and inexpensive drugs have been tested by the public, some for almost 100 years that have saved thousands of lives, yet they are not given the FDA stamp of approval!  In fact, the FDA tries to put these drugs out of circulation, replacing them with very expensive drugs that are new! Or they just shut them down, because they are not FDA approved.  Young doctors are told not to use them by their medical schoolteachers who rarely have experienced these medications in private practice…. These doctors in training don't know the history of older safer, cheaper drugs, or even why the FDA tells them avoid them. They comply not knowing why, so you are left with no drug that works for you, or you pay 3-10 times the amount for a newer FDA version of the older drug which may even have more side effects. Some of these older very effective and cheap drugs are Penicillin, Nitroglycerine for chest pain, Morphine (pain), Phenobarbital (seizures), Codeine, Armour Thyroid, hormone injections including estradiol injections and testosterone, Thorazine for psychiatric use, (Pitocin) oxytocin for labor, lactation support and Autism Colchicine:Used to treat and prevent gout. Progesterone in oil (IM) Estradiol in oil (IM) B12 for injection Testosterone Cypionate for injection Compounded Estradiol in any form Compounded Testosterone for women These drugs have been used for so long that any safety risks or side effects have been found through the use of these drugs in the population. Yet the FDA won't grandfather them in and approve them based on their history! What do doctors do when the drug the FDA has approved a drug that doesn't work for a group of their patients (gender, race, blood type, etc.)?  What happens when a doctor can't find a drug that is FDA approved needed to treat a condition she is faced with? Why do we as citizens, allow the government to have power over doctors who are already controlled by their state licensing boards as to what medications they?  Lastly Why do taxpayers allow a government agency that they fund with tax dollars control their health by banning, or not approving drugs, or banning one drug so an outrageously expensive drug is put in its place? Compounded Medications/ Compounding Pharmacies: These drugs are made by mixing ingredients to meet individual patient needs and are not subject to premarket review for safety, effectiveness, or quality. However, they ARE subject to the success or failure for which they were prescribed. If a doctor prescribes a compounded drug that doesn't work, she is apt to be confronted by her patient who is not getting the expected results.  Compounding pharmacies usually don't get paid by insurance, so patients are more invested in getting a drug that works and that is one of the big reasons that Compounded medicines are at least as good or better than big pharma or generic drugs. I absolutely could not successfully treat the thousands of women and men that I have without compounding pharmacies.  They compound hormones/drugs that are safe and effective, mostly hormones that can't be patented because they occur in nature and won't ever be made by big pharma. More than that, big producers of drugs can't produce in mass quantities many doses of a certain hormone like compounding pharmacies do.  Compounding pharmacies provide what people need and they continue to do so because patients prefer their dosing and quality.  FDA approved Generic Drugs can be legally 25 % lower dose than what they say they are.  That would be a big problem if my compounded pellets had that kind of variability. People might need pellets every 2months or every 5 months instead of every 4 months..it would be like guessing what you need ahead of time…..I believe dedicated compounding pharmacists are more accurate than any generic on the market. Compounding pharmacies: Unsung Heros Compounding pharmacies serve the public when big pharma fails and hasn't developed a safety net for production if they have a problem and the FDA shuts them down. That situation leaves patients who take their medications, without an alternative. Compounding pharmacies step into the breech when big pharma has a problem with a particular drug and stop making a drug (e.g. Lidocaine, B12 injectable, IV Fluids, to name a few shortages and no production that have occurred in the recent past). What if patients couldn't get the meds they need, and if there were no compounding pharmacies—Chaos and suffering and dying patients would closely follow! The FDA is Fickle and is not on your side! For years the FDA did not approve of Bioidentical estrogen and testosterone in any form, and just a few months ago all of a sudden, long after they scared women from taking the hormones they needed to improve their length of life and quality of life, they decided bioidentical hormones are better than the FDA approved hormones!!!  That is a little too late.  Some of us will never forget the stress lack of approval of compounded hormones caused for doctors and patients alike.  Other doctors criticized us and now most of them aren't even in practice anymore.  Maybe the FDA read my blog!!! Compounded hormones have been approved by the masses of women who have taken them under my signature! Compounded BI hormones are medications with a long track record and should not have to be tested with the bloated expense required of testing for the FDA. For Gynecological Disorders that don't have an FDA approved hormone drug because testosterone and estradiol have been used for so long that they don't need testing. If there was a significant problem with them their history of use of over 5-7 decades has proven the efficacy and safety of the female hormones for treatment and hormone replacement. For Psychiatric Disorders: Some patients need compounded ketamine products for conditions like severe depression, despite lacking FDA approval for these uses and potential risks, yet it has been used for this purpose for decades and was used for childbirth for almost a century, until epidurals and saddle blocks took their place. Testosterone for women still is not recognized as a female hormone even though women produce over twice as much Testosterone as Estradiol when they are in their fertile years.   Replacement of T with bioidentical T pellets offers a treatment for dozens of symptoms women face after age 40, and it prevents the diseases of aging: osteoporosis, heart disease, sarcopenia, frailty, diabetes and more that have not been addressed by mainstream medicine and the FDA. Over a decade ago, the FDA turned down the approval of testosterone patch after over 3 years of positive research studies, the FDA said they didn't approve T for women is because the side effect of T for women, facial hair, was dangerous for women.…I cry B—–S—-!  That is really men not wanting to share testosterone replacement with women. I say leave us alone and let women and their doctors determine what they need.  It is proven that only 5% of all professionals in any profession are not trustworthy, so give doctors their due and trust that we are looking for answers to our patients' problems that you don't even know about! The FDA is paid for by us…everyone in this country. I say hands off! Speed up the approval process or forget it for older drugs and BI hormones! ~

On this episode of Taste Buds with Deb, host Debra Eckerling speaks with Noah Rothbaum, author of “The Whiskey Bible: A Complete Guide to the World's Greatest Spirit,” among others.    In the book - and in the interview - Rothbaum shares everything you ever wanted to know about whiskey, and more, including the pivotal role of Jewish immigrants in bringing whiskey to America.    “In many ways, American Jews invented whiskey in this country or at least helped popularize it, around the turn of the century, the late 1800s to 1900s,” Rothbaum explains. Because of the laws of kashrut, Jews were accustomed to making their own alcohol in the old country; a skill they brought with them when they started emigrating to America and Canada.   “Fortunately the rules for making spirits are a lot simpler than the rules for making wine,” he explains. “Most whiskey by its very nature is kosher … because there's only really three ingredients: water, yeast and grain. … The fourth ingredient is the barrel, because all whiskey comes off the still clear; the color and so much of the flavor comes from the barrel.”   “The Whiskey Bible” contains more than 600 pages of knowledge, history, and stellar recipes from bartenders from around the world, including one from Sam Ross, called "penicillin."    When Rothbaum asked where the name came from, Ross said that when he was smelling the cocktail - the different kinds of notes from the whiskey and the honey ginger syrup and the citrus - it reminded him of chicken soup aka Jewish penicillin.   More than anything, Rothbaum wants to elevate people's knowledge of and confidence in drinking whiskey.    “I wanted folks to feel empowered and savvy.” Rothbaum says. When someone hears something about whiskey, whether it's from their colleague, a know-it-all friend or they see a movie where somebody's drinking it, they can pull out “The Whiskey Bible, flip to that page or section and see what's what.   Noah Rothbaum shares his journey into the world of whiskey, numerous whiskey facts and points of history, and Sam Ross' penicillin recipe, which you can find at JewishJournal.com/podcasts.    Get “The Whiskey Bible” at your favorite bookstore and follow @Noah_Rothbaum on Instagram. For more from Taste Buds, subscribe on iTunes and YouTube, and follow @TheDEBMethod on social media.

Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI  Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.

Mes chers camarades, bien le bonjour !Parfois on découvre des trucs par hasard et ça fait grave plaisir. Et quand on parle d'Histoire, on voit que c'est pas si rare que ça ! Même en science, la chance fait parfois la différence, un peu comme Christophe Colomb qui part pour les Indes, mais tombe sur l'Amérique ! Alors c'est parti pour un petit top des découvertes médicales dues au hasard !Bonne écoute !

National Double Cheeseburger day. Entertainment from 1996. 1st 8 track tape players installed in cars, Tanks used for the 1st time in battle, Penicillin discovered. Todays birthdays - Marco Polo, Roy Acuff, William Howard Taft, Agatha Christie, Fay Wray, Oliver Stone, Tommy Lee Jones, Kelly Keagy, Wendie Jo Sperber. Ric Ocasek died.Intro - God did good - Dianna Corcoran    https://www.diannacorcoran.com/McDonald's burger rap - Sherman GanMacarena - Los Del RioSo much for pretending - Bryan WhiteBirthdays - In da club - 50 Cent     http://50cent.com/The wabash canonball - Roy AcuffSister christian - Night RangerShake it up - The CarsExit - A memory I can't drown - Anthony Price    https://anthonypricemusic.com/countryundergroundradio.com History & Factoids webpage

In this continuation of their conversation, Chris Maffeo interviews Federico Riezzo about modern cocktail classics, Villa Mamo's terroir-driven approach, and scaling cocktail culture. Federico reflects on cocktail legends like Douglas Ankrah and the era that created enduring drinks like the Pornstar Martini, Penicillin , and Breakfast Martini, while exploring why new cocktails struggle to achieve lasting status in today's social media environment.Learn about Villa Mamo, Federico's renovated 1786 Tuscan farmhouse and boutique hospitality venue, where he collaborates with local foragers to create hyper-local botanical cocktails using terroir-driven ingredients. Discover Federico's lower ABV cocktail philosophy that encourages extended social drinking experiences and better guest engagement.Chris and Federico examine the cocktail industry's workforce challenges, discussing how modern bartenders increasingly prioritize technical innovation over essential hospitality skills like guest reading and relationship building.Perfect for bar managers, hospitality professionals, cocktail enthusiasts, and anyone interested in sustainable cocktail culture, terroir-driven mixology, and the future of the bar industry.Timestamps :00:00 From Douglas Ankrah's Porn Star Martini to the other Modern Classics08:15 Cocktail Culture Gap Analysis16:30 Villa Mamo's Terroir Approach24:45 Lower ABV Philosophy and Social Drinking32:20 Industry Workforce Challenges40:04 Future of Hospitality and Scaling Culture

"Ich liebe Penicillin", sagt die Infektiologin PD Dr. Dr. Katja de With. Manche Antibiotika wie Penicillin würden in Deutschland zu wenig genutzt, andere dann wieder ohne gute Begründung eingesetzt. Die Expertin spricht in dieser Folge über Wirkmechanismen, den etwas unpassenden Ausdruck "Breitbandantibiotika" und gibt Tipps, wie Antibiotika so wirksam und toxizitätsarm wie möglich eingesetzt werden können.

Convenience and quality don't always go hand in hand, but Tip Top Cocktails is changing that perception, one perfectly crafted drink at a time. Founded in 2019, Tip Top is an Atlanta-based brand known for its spirit-forward, bar-quality offerings. Childhood friends Yoni Reisman and Neal Cohen launched the company with a simple mission: make great cocktails more accessible, no bartender required. Tip Top's lineup includes time-honored classics like the Old Fashioned, Negroni, and Margarita, as well as modern favorites such as the Paper Plane, Penicillin, and Naked & Famous. Each cocktail is precisely mixed and served in a sleek 100 mL lowball-style can. The products are available in over 25 U.S. states and Washington, D.C., and carried by national retailers such as Trader Joe's, Whole Foods, Gelson's Markets, and Total Wine & More. Amid a rapidly expanding market for RTD cocktails, Tip Top has earned high praise from The New York Times, Food & Wine, and other publications. Perhaps surprisingly, the company hasn't taken any institutional funding to date. In this episode, Yoni and Neal share how an idea sparked on the music festival circuit evolved into a fast-growing brand with national reach. Their journey is a case study in bootstrapping, brand discipline, and building loyalty through an unwavering commitment to quality and customer experience. Show notes: 0:25: Interview: Neal Cohen & Yoni Reisman, Co-Founders, Tip Top Cocktails – The co-founders discuss how Tip Top's origins stem from Yoni's time in the music festival scene, recruiting award-winning bartender Miles Macquarrie to help develop the cocktails and how they emphasized authentic, balanced flavors and supported that with retro-inspired branding and educational elements like listing ingredients. Neal and Yoni also talk about Tip Top's collaborations with renowned bartenders such as Sam Ross and Joaquín Simó and how it reinforced the brand's credibility and dedication to cocktail culture. They also explain how Tip Top has relied on grassroots marketing, standout packaging, and word-of-mouth to build its brand, with its 100 mL can seen as both stylish and practical and how the company has earned respect within the hospitality industry and among professional bartenders. They explain why they continue to personally taste each batch of cocktails and have scrapped full runs when standards weren't met and how “building a brand people would truly miss” if it left the market is their North Star. Brands in this episode: Tip Top Cocktails, Straightaway Cocktails, Post Meridiem

Penicillin is the go-to antibiotic for many common infections - but in the UK more than 1-in-15 adults have a penicillin allergy label on their medical record. New research suggests that many with these labels are not actually allergic. Professor Sue Pavitt explains how more accurate allergy labelling might help fight the rise of antimicrobial resistance. Both Burundi and Senegal announced last week that they had eliminated trachoma. Dr Graham Easton walks us through the long road to this milestone.A passionate debate has caused division in Maharashtra, India, over the possibility of homeopaths being allowed to practice and prescribe conventional medicine. Reporter Chhavi Sachdev explains why doctors on both sides are striking. In the UK, eight babies made with the combined genetic material of three people have been born without the hereditary mitochondrial disease. We explore the implications of this breakthrough. Sex at birth might not be as random as we once thought; a new study found that families with three children of the same sex are more likely to have another child of the same sex.Presenter: Claudia Hammond Producer: Hannah Robins Assistant Producer: Alice McKee Studio Managers: Dyfan Rose and Andrew Garrett

Don researches one of the most challenging bomb cases in FBI history, a mysterious encounter with a legendary beast and an artful scientist that accidentally uncovered a revolutionary medicine. Hosted on Acast. See acast.com/privacy for more information.

In this episode of Barrel Room Chronicles, host Kerry Moynahan explores two unique sides of the American spirits revolution—one driven by finance, the other by flavor.First, Kerry sits down with Ryan LaValle and Hunter Robillard, of ASM Capital Partners, a venture firm dedicated to fueling the future of American Single Malt whiskey. From Hunter's early days helping his father create a maple-infused whiskey brand to Ryan's transition from Wall Street to whiskey investment, this duo is helping bridge the gap between distilleries and capital. They discuss how whiskey becomes an asset class, what makes American Single Malt such a compelling category, and how ASM is empowering distilleries to grow through thoughtful investment and strategic support.Then, in Tavern Talk Kerry speaks with Neal Cohen, co-founder of Tip Top Proper Cocktails. From their humble beginnings inspired by the music festival circuit to landing on Delta Airlines, Tip Top is redefining what ready-to-drink (RTD) cocktails can be. Neal walks us through their whiskey-forward offerings—from their high-rye bourbon Old Fashioned to their award-winning Penicillin—and shares how they've built a brand rooted in balance, convenience, and craft.Whether you're a whiskey enthusiast, an investor, or just someone curious about the next frontier in spirits, this episode pours you a full measure of insight and inspiration.

本期节目来到上海的新进话题酒吧Penicillin。作为亚洲50 Best酒吧的姊妹店，在上海也注定备受关注。火爆的长队、精致的装修、有点先锋的酒饮，还有社交媒体中关于这家店的各种讨论。钱老板在Penicillin周五开档前潜入，和调酒师Chris简单聊了聊。 如果您对葡萄酒、烈酒、啤酒或其他酒精饮料有兴趣，不妨关注公众号，或联系「杯弓舌瘾小助手」进入团购群。如果您是供应商，也可以向我们推荐合适的产品。 可以尝试在SOLUTION逮捕钱老板，地址是上海市静安区常德路529号。 关注「杯弓舌瘾」公众号，或微信搜索bgsyxzs加入听众交流群，欢迎您参与互动。 - 对话成员 - 钱老板（小红书：@钱老板） Chris（Penicillin - 上海） - 本节目由 JustPod 出品 ©上海斛律网络科技有限公司 - - 互动方式 - 商务合作：ad@justpod.fm 微博：@杯弓舌瘾TipsyProof 微信公众号：杯弓舌瘾

On episode #81 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 5/8/25 – 5/21/25. Hosts: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo (NEJM) Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases) Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP) Impact of most promising Ebola therapies on survival (Virology Journal) Bacterial Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams (CID) Diet and Risk for Incident Diverticulitis in Women (Annals of Internal Medicine) The Dynamics of QuantiFERON-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents(American Journal of Respiratory and Critical Care Medicine) BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection(NEJM) The Impact of Diet on Clostridioides difficile Infection (JID) Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcusaureus Bacteremia (CMI: Clinical Microbiology and Infection) Fungal The Last of US Season 2 (YouTube) Candida auris is emerging as a prevalent urinary pathogen (PLoS Pathgoens A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis (Science) Outcome predictors of Candida prosthetic joint infections (OFID) Cave-Associated Histoplasmosis Outbreak Among Travelers Returning from Costa Rica — Georgia, Texas, and Washington, December 2024–January 2025 (CDC: MMWR) Parasitic COPEG 25th Anniversary (US Embassy in Panama) USDA suspends southern border livestock imports over New World screwworm threat(CIDRAP) Moxidectin combination therapies for lymphatic filariasis (LANCET: Infectious Diseases Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

This week, Hackaday's Elliot Williams and Kristina Panos met up across the universe to bring you the latest news, mystery sound, and of course, a big bunch of hacks from the previous week. In Hackaday news, the 2025 Pet Hacks Contest rolls on. You have until June 10th to show us what you've got, so head over to Hackaday.IO and get started today! On What's That Sound, Kristina actually got it this time, although she couldn't quite muster the correct name for it, however at Hackaday we'll be calling it the "glassophone" from now on. Congratulations to [disaster_recovered] who fared better and wins a limited edition Hackaday Podcast t-shirt! After that, it's on to the hacks and such, beginning with a complete and completely-documented wireless USB autopsy. We take a look at a lovely 3D-printed downspout, some DIY penicillin, and a jellybean iMac that's hiding a modern PC. Finally, we explore a really cool 3D printing technology, and ask what happened to typing 'www.'. Check out the links below if you want to follow along, and as always, tell us what you think about this episode in the comments!  

Our ability to solve complex problems without AI has plummeted 30% in just five years. That's not just a statistic – it's the sound of your brain cells surrendering. We are announcing a new series we are calling –  Creative Thinking in the AI Age – on strengthening your uniquely human creativity while using AI as a partner, not a replacement. Today, we will explore how AI dependency is creating a pandemic of reduced creative thinking and why this matters more than you might realize. Look around. We've all seen it – colleagues endlessly prompting AI for answers, friends asking their devices the same questions with slight variations, and kids who reach for ChatGPT before trying to solve a problem themselves. It's happening everywhere. We're witnessing a slow, subtle decline in our collective ability to think deeply, creatively, and independently. This cognitive shift is measurable. Recent research from the University of Toronto found that college students today show a 42% decrease in divergent thinking scores – our ability to generate multiple solutions to problems – compared to students just five years ago. The difference? The widespread adoption of AI tools. This isn't just happening in schools. Creative professionals show similar patterns. Marketing agencies report that junior staff increasingly struggle to generate original campaign concepts without AI prompting. Engineering teams face growing difficulties when asked to ideate without computational assistance. But this isn't a rant against technology. AI is here to stay, and it offers tremendous benefits. The real issue is how our relationship with these tools is reshaping our cognitive capabilities. Remember when calculators became widespread? Many feared we'd lose our ability to do basic math. They weren't entirely wrong, but we adapted. The difference now is that AI doesn't just handle calculations – it's beginning to think for us. This surrender of our thinking faculties brings us to an uncomfortable but powerful concept from theologian Dietrich Bonhoeffer. Writing from a Nazi prison in 1943, he described a phenomenon he called "stupidity" – not as a lack of intelligence, but as a social contagion where independent thinking is surrendered to external forces. Bonhoeffer wasn't talking about AI, obviously. But his insight that humans will easily surrender their thinking faculties to external authorities is profoundly relevant today. We're increasingly outsourcing our cognitive heavy lifting to algorithms, and our brains are adapting accordingly. Let me show you what I mean with a quick demonstration. Take 30 seconds right now to list five uncommon uses for a paperclip. No use of AI. I'll wait. How'd you do? If you struggled, you're not alone. In tests conducted before widespread AI adoption, the average person could generate 8-12 unique ideas. Today, that number has dropped to 3-5. This decline in creative thinking ability is not only disappointing – it has neurological implications. When we regularly outsource thinking, the neural pathways associated with creative problem-solving literally weaken. It's cognitive atrophy – it's like any other muscle, use it or lose it. And with AI, you aren't using it. The consequences are more serious than you might think. Here's what's happening: AI is great at finding the optimal solution within defined boundaries using "convergent thinking." Give AI the parameters of a problem, and it'll efficiently identify the best answers within a set of constraints. But what humans uniquely excel at is "divergent thinking" – our ability to break through boundaries, reimagine the entire problem, and make unexpected connections between seemingly unrelated ideas. This is where breakthroughs happen. Recent research from the University of Bergen shows that while AI can generate more ideas than the average person, the most creative human solutions significantly outperform AI in originality and innovation. Here's the paradox: the more we rely on AI, the more we get trapped in what psychologists call "AI-reinforced conventional thinking." Let me demonstrate. In a creative thinking workshop I ran not long ago, I asked participants to design a new coffee cup. Most drew variants of the same cylindrical container with a handle. When asked why, they couldn't explain – they'd simply imposed an invisible constraint. But when one participant suggested a coffee cup that could be worn as a ring, the floodgates opened. Suddenly, people were designing coffee cups that doubled as plant holders, that changed color with temperature, and that folded flat for storage. This mental breakthrough reveals what neuroscientists call the "first insight phenomenon" – that moment when one disruptive idea shatters the invisible walls of conventional thinking and unleashes a cascade of creative possibilities. We're not just limited by what we know, but by what we don't realize we're assuming. When we look at history's greatest innovations, this ability to think beyond self-imposed constraints becomes even more critical. The transistor. Penicillin. The theory of relativity. The internet itself. None of these came from incremental optimization. They required creative leaps that defied conventional thinking – precisely the kind of thinking we're at risk of losing in our growing dependency on AI. But here's the good news – research from cognitive neuroscience and psychology confirms what I've seen firsthand: our thinking skills can be systematically improved. We can rebuild and strengthen these creative pathways with the right techniques. This is where the concept of neuroplasticity becomes crucial. Like muscles, cognitive abilities respond to consistent, targeted exercise. And just as we've developed scientific approaches to physical fitness, we now have evidence-based methods for improving creative thinking skills. The research findings are encouraging: In just minutes a day of targeted practice, people show measurable improvements in creative output. And unlike many skills that decline with age, creative thinking can actually improve throughout our lives – if we nurture it. We stand at a crossroads. One path – cognitive surrender – is seductively easy. The other path requires effort but leads to something extraordinary: a partnership where AI handles the routine while we cultivate our uniquely human capacity to imagine what has never existed before. Here's what gives me tremendous hope: our brains remain remarkably adaptable throughout our entire lives. In the next episode, we'll dive into this revolutionary science and learn how to rewire our thinking for an AI-augmented world without losing what makes us human. Join me for "Creative Neuroplasticity: The Science of Enhanced Creative Thinking." Until then, I'm Phil McKinney, and remember – in an age of artificial intelligence, authentic human thinking has never been more important. Your support means everything to this channel. And if you're passionate about creativity and innovation, consider becoming a patron on Patreon or a subscriber on Substack. Your support helps make this content possible.

Contributor: Geoff Hogan MD Educational Pearls: Penicillin allergies are relatively uncommon despite their frequent reports 10% of the population reports a penicillin allergy but only 5% of these cases are clinically significant 90-95% of patients may tolerate a rechallenge after appropriate allergy evaluation Penicillin Allergy Decision Rule (PEN-FAST) on MD Calc Useful tool to assess patients for penicillin allergies Five years or less since reaction = 2 points (even if unknown) Anaphylaxis or angioedema OR Severe cutaneous reaction = 2 points  Treatment required for reaction (e.g. epinephrine) = 1 point (even if unknown) A score of 0 on PEN-FAST indicates a less than 1% risk of a positive penicillin allergy test A score of 1 or 2 indicates a 5% risk of a positive penicillin allergy test A low score on PEN-FAST should prompt clinicians to proceed with the best empiric antibiotic for the patient's infection References Broyles AD, Banerji A, Barmettler S, et al. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs [published correction appears in J Allergy Clin Immunol Pract. 2021 Jan;9(1):603. doi: 10.1016/j.jaip.2020.10.025.] [published correction appears in J Allergy Clin Immunol Pract. 2021 Jan;9(1):605. doi: 10.1016/j.jaip.2020.11.036.]. J Allergy Clin Immunol Pract. 2020;8(9S):S16-S116. doi:10.1016/j.jaip.2020.08.006 Piotin A, Godet J, Trubiano JA, et al. Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule [published correction appears in Ann Allergy Asthma Immunol. 2022 Jun;128(6):740. doi: 10.1016/j.anai.2022.04.005.]. Ann Allergy Asthma Immunol. 2022;128(1):27-32. doi:10.1016/j.anai.2021.07.005 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review. JAMA. 2019;321(2):188-199. doi:10.1001/jama.2018.19283 Trubiano JA, Vogrin S, Chua KYL, et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Intern Med. 2020;180(5):745-752. doi:10.1001/jamainternmed.2020.0403 Summarized & edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

Like tens of millions of people, Stephen Dubner thought he had a penicillin allergy. Like the vast majority, he didn't. This misdiagnosis costs billions of dollars and causes serious health problems, so why hasn't it been fixed? And how about all the other things we think we're allergic to? SOURCES:Kimberly Blumenthal, allergist-immunologist and researcher at Mass General Hospital and Harvard Medical School.Theresa MacPhail, associate professor of science and technology studies at Stevens Institute of Technology.Thomas Platts-Mills, professor of medicine at the University of Virginia.Elena Resnick, allergist and immunologist at Mount Sinai Hospital. RESOURCES:Allergic: Our Irritated Bodies in a Changing World, by Theresa MacPhail (2023)."Evaluation and Management of Penicillin Allergy: A Review," by Erica S. Shenoy, Eric Macy, and Theresa Rowe (JAMA, 2019)."The Allergy Epidemics: 1870–2010," by Thomas Platts-Mills (The Journal of Allergy and Clinical Immunology, 2016)."Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy," by George Du Toit, Graham Roberts, et al. (The New England Journal of Medicine, 2015). EXTRAS:Freakonomics, M.D.

Bomani Jones starts today's show by recapping the Cowboys vs Lions matchup. (0:50) He reiterates his Day 1 fandom of the Detroit Lions, while reveling in the blow out win over the Dallas Cowboys. Bomani explains that he had Super Bowl aspirations for this team right until the Aidan Hutchinson injury, which has certainly hurt the teams morale. Speaking of morale, the Cowboys look terrible following that loss and Bo discusses why they showed zero fight in that game. (9:30) From there, Bomani transitions to Nick Sirianni and the Eagles, who despite the win over the Browns, have a coach who should be fired. Bo stresses his disdain for bringing your kids up to the podium during a press conference especially when they're being used as human shields. (16:40) Then Bomani briefly talks about Lincoln Riley who has lead the USC Trojans to three straight losses. And finally, another round of If You Haven't Heard stories and your Al Bundy voicemail stories. (34:00) IYHH Contributors:  Matteo Wong, Staff Writer at The Atlantic: “AI's Penicillin and X-Ray Moment” https://bit.ly/4eI8je2  Oshan Jarow, Staff Writer at Vox: “Nitrous, one of the oldest mind-altering drugs, is back" https://bit.ly/3NKRnb7  Allie Kelly, Reporter at Business Insider: “A major curveball in retirement preparedness: divorce” https://bit.ly/3BCFzEL  . . . Subscribe to The Right Time with Bomani Jones on Spotify, Apple or wherever you get your podcasts and follow the show on Instagram, Twitter, and Tik Tok for all the best moments from the show. Download Full Podcast Here: Spotify:  https://open.spotify.com/show/6N7fDvgNz2EPDIOm49aj7M?si=FCb5EzTyTYuIy9-fWs4rQA&nd=1&utm_source=hoobe&utm_medium=social Apple:  https://podcasts.apple.com/us/podcast/the-right-time-with-bomani-jones/id982639043?utm_source=hoobe&utm_medium=social Follow The Right Time with Bomani Jones on Social Media:  http://lnk.to/therighttime Support the Show:  PrizePicks: Daily Fantasy Made Easy! Visit PrizePicks.com/BOMANI and use code BOMANI for a first deposit match up to $100! Download the Viator app now to use code VIATOR10 for 10% off your first booking in the app. Cut your wireless bill to 15 bucks a month at MintMobile.com/Bomani. Learn more about your ad choices. Visit megaphone.fm/adchoices

In 1980s Berkeley, an eccentric chemist and his wife, a self-taught therapist, experimented with MDMA. Their work would kickstart a decades-long campaign to mainstream psychedelics as a therapeutic tool — one that's coming to a head this month, with a decision due from the FDA. This episode was reported and produced by Haleema Shah, edited by Lissa Soep and Matt Collette, fact-checked by Laura Bullard, engineered by Andrea Kristinsdottir and Rob Byers, and hosted by Sean Rameswaram. It's the second in a series supported with a grant from the Ferriss–UC Berkeley Psychedelic Journalism Fellowship. Transcript at vox.com/today-explained-podcast Support Today, Explained by becoming a Vox Member today: http://www.vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices