Podcasts about Penicillin

Matters Microbial #112: Bacterial Size, Stress, and Antibiotic Resistance October 17, 2025 Today Dr. Petra Levin, the George and Irene Freiberg Professor of Biology at Washington University in St. Louis joins the #QualityQuorum to discuss her work with bacterial cell size, environmental stress on bacteria, and antibiotic resistance. Host: Mark O. Martin Guest: Petra Levin Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An overview of the periplasm, found in Gram negative bacteria. An overview of beta-lactam antibiotics. The field of quantitative microbiology. An overview of B. subtilis.  An overview of E. coli.  An overview of Klebsiella.  The biography of Barbara McClintock, “A Feeling for the Organism.” A video explanation of the lac operon of E. coli. The LTEE program (Long Term Evolution Experiment) founded by Dr. Rich Lenski. The nomenclature of monoderm and diderm bacteria. A video explanation of peptidoglycan in bacteria. Penicillin binding proteins (PBP) and antibiotic resistance. A video about cell division in E. coli. A famous article coauthored by Dr. Elio Schaechter that describes cell growth and cell size in bacteria. A related article by Dr. Levin and colleagues. An overview of ESKAPE bacteria. An article from Dr. Levin's research group describing the relationship between pH and antibiotic resistance. An article about persister cells and their relevance to antibiotic resistance. Dr. Levin's faculty website. Dr. Levin's very interesting laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog If you ever doubted your doctor because she wrote a script that you later “Googled” and found was not FDA approved, I hope you trusted your doctor enough to realize that she wouldn't recommend any medication that would hurt you…. What is an unapproved use of a drug, also called “off-label”? Unapproved use of an approved drug is often called “off-label” use. This term can mean that the drug is: Used for a disease or medical condition that it is not approved to treat, such as when a chemotherapy is approved to treat one type of cancer, but healthcare providers use it to treat a different type of cancer. The drugs that are not approved by the FDA, yet are commonly used, have been used for decades before the 1964 law that required new drugs to go through extensive and very expensive testing before their release to the public. The operative word is NEW DRUGS AFTER 1964. Today I will talk about the safety of non-FDA approved drugs because they are: Older cheaper drugs used for many diseases and conditions before 1964 and are still used Drugs that are approved for one use, or one condition, but not for other conditions that it is effective and safe for. Drugs made by compounding pharmacies for diseases that the FDA has not approved a drug for, but there is research backing the drug and years of safe use. First, before we discuss the non-FDA approved drugs, I will discuss the safety/risks of FDA approved drugs, and why FDA approval doesn't mean a drug will do no harm or even that it is effective for the use it is approved for. A little background will help you understand the problem and the reason an FDA approval does not necessarily mean a drug is safe.  Since 1964, a law was passed that established testing prior to a drug being approved by the FDA became mandatory.   Since that time several drugs that survive FDA approval and are released but are later removed or banned after their FDA release when the public finds side effects that the FDA didn't discover in their trials. One such drug is Fen-Phen, Fenfluramine/Phentermine. This drug was released during my time practicing medicine and was withdrawn after one study claimed it caused heart valve disease…In the end the “one post approval study” that claimed that heart valves were affected by this drug that caused its bann was found to be false. The withdrawal of the drug followed one study by a single cardiologist from Kansas City had reviewed all of the cardiac valve echo tests and falsified the results to make Fen-Phen appear dangerous to heart valves, when in reality it wasn't.  She lost her license, but the FDA never put Fen-Phen back on the market!  The FDA hates to be wrong twice, so they never allowed this drug back on the market after its removal. Other mistakes made by the FDA include not allowing women in the studies to approve a drug before 2014 which ignores or misses all of the side effects or lack of effectiveness for a drug when taken by women.  Despite all the expensive testing before the release of a drug by the FDA, many drugs not tested on women were later often found to have severe side effects only on women. A few examples follow: You might have heard of the FDA approved drug Ambien that causes many women to experience “night eating”, sleepwalking, and night terrors, while their male counterparts were not affected, so because they only tested men the drug was approved. In retrospect it should have been tested on women as well, and then either not passed through the FDA or should have had a black box warning for women. It takes years get action from the FDA, notifying doctors of these side effects. Women were not included in testing for any drugs except female hormones until 11 years ago, but no other drugs.   Before 2014 all (non-hormonal) drugs that passed the FDA were not tested on women so the effect on women was unknown until it was tested on the public. The FDA left women out of drug-trials because it viewed women as “mini men”, or they didn't consider us important enough to test new drugs on…OR worse, they believed we were too complicated to easily test us because of pregnancy, menopause and other hormonal swings that normal healthy women have.  In any case, we are now suffering their decisions, when a medication works one way for men and another way for women! Finally, we are tested when drugs are being evaluated for approval by the FDA. Professional women have achieved a level of authority in medicine and pharmacology (2025) and are weighing in on the inequity. Women in the medical profession and the public are pulling back the curtain on the side effects of FDA approved drugs that are experienced by women only! Slowly, study by study investigators are now publishing the side effects and problems for women with FDA approved drugs….yet these findings are not included in the warnings on most of these drugs, even now over 15 year after they became obvious to the doctors who treat women! Drugs that either don't work for women, or that have severe side effects include that were approved before 2014. All statin drugs for high cholesterol (Crestor, rosuvastatin, atorvastatin, etc.) cause women to have muscle breakdown and muscle pain. Synthroid (levothyroxine), doesn't cure the symptoms of hypothyroidism in 80% of women, but just makes the TSH lower, so it appears as if it is working! This leads doctors to tell women that their symptoms are all in their heads!! Wrong.  It is the wrong medicine. Women have enzymes that differ from men that make it difficult for them to convert the inactive form (T4) into the active form (T3), so we can't convert Synthroid (all T4) into the active form. Synthroid, the FDA approved drug for hypothyroidism, shouldn't be given to most women. Women should be given the non-FDA approved drug Armour Thyroid or NP thyroid that have both T3 and T4 in them! Ambien Prednisone and other oral steroids We have reviewed the lack of testing on women before 2014, now we will discuss safe drugs that have been used for decades even before 1964 when the FDA required testing for FDA approval? Older, yet effective and inexpensive drugs have been tested by the public, some for almost 100 years that have saved thousands of lives, yet they are not given the FDA stamp of approval!  In fact, the FDA tries to put these drugs out of circulation, replacing them with very expensive drugs that are new! Or they just shut them down, because they are not FDA approved.  Young doctors are told not to use them by their medical schoolteachers who rarely have experienced these medications in private practice…. These doctors in training don't know the history of older safer, cheaper drugs, or even why the FDA tells them avoid them. They comply not knowing why, so you are left with no drug that works for you, or you pay 3-10 times the amount for a newer FDA version of the older drug which may even have more side effects. Some of these older very effective and cheap drugs are Penicillin, Nitroglycerine for chest pain, Morphine (pain), Phenobarbital (seizures), Codeine, Armour Thyroid, hormone injections including estradiol injections and testosterone, Thorazine for psychiatric use, (Pitocin) oxytocin for labor, lactation support and Autism Colchicine:Used to treat and prevent gout. Progesterone in oil (IM) Estradiol in oil (IM) B12 for injection Testosterone Cypionate for injection Compounded Estradiol in any form Compounded Testosterone for women These drugs have been used for so long that any safety risks or side effects have been found through the use of these drugs in the population. Yet the FDA won't grandfather them in and approve them based on their history! What do doctors do when the drug the FDA has approved a drug that doesn't work for a group of their patients (gender, race, blood type, etc.)?  What happens when a doctor can't find a drug that is FDA approved needed to treat a condition she is faced with? Why do we as citizens, allow the government to have power over doctors who are already controlled by their state licensing boards as to what medications they?  Lastly Why do taxpayers allow a government agency that they fund with tax dollars control their health by banning, or not approving drugs, or banning one drug so an outrageously expensive drug is put in its place? Compounded Medications/ Compounding Pharmacies: These drugs are made by mixing ingredients to meet individual patient needs and are not subject to premarket review for safety, effectiveness, or quality. However, they ARE subject to the success or failure for which they were prescribed. If a doctor prescribes a compounded drug that doesn't work, she is apt to be confronted by her patient who is not getting the expected results.  Compounding pharmacies usually don't get paid by insurance, so patients are more invested in getting a drug that works and that is one of the big reasons that Compounded medicines are at least as good or better than big pharma or generic drugs. I absolutely could not successfully treat the thousands of women and men that I have without compounding pharmacies.  They compound hormones/drugs that are safe and effective, mostly hormones that can't be patented because they occur in nature and won't ever be made by big pharma. More than that, big producers of drugs can't produce in mass quantities many doses of a certain hormone like compounding pharmacies do.  Compounding pharmacies provide what people need and they continue to do so because patients prefer their dosing and quality.  FDA approved Generic Drugs can be legally 25 % lower dose than what they say they are.  That would be a big problem if my compounded pellets had that kind of variability. People might need pellets every 2months or every 5 months instead of every 4 months..it would be like guessing what you need ahead of time…..I believe dedicated compounding pharmacists are more accurate than any generic on the market. Compounding pharmacies: Unsung Heros Compounding pharmacies serve the public when big pharma fails and hasn't developed a safety net for production if they have a problem and the FDA shuts them down. That situation leaves patients who take their medications, without an alternative. Compounding pharmacies step into the breech when big pharma has a problem with a particular drug and stop making a drug (e.g. Lidocaine, B12 injectable, IV Fluids, to name a few shortages and no production that have occurred in the recent past). What if patients couldn't get the meds they need, and if there were no compounding pharmacies—Chaos and suffering and dying patients would closely follow! The FDA is Fickle and is not on your side! For years the FDA did not approve of Bioidentical estrogen and testosterone in any form, and just a few months ago all of a sudden, long after they scared women from taking the hormones they needed to improve their length of life and quality of life, they decided bioidentical hormones are better than the FDA approved hormones!!!  That is a little too late.  Some of us will never forget the stress lack of approval of compounded hormones caused for doctors and patients alike.  Other doctors criticized us and now most of them aren't even in practice anymore.  Maybe the FDA read my blog!!! Compounded hormones have been approved by the masses of women who have taken them under my signature! Compounded BI hormones are medications with a long track record and should not have to be tested with the bloated expense required of testing for the FDA. For Gynecological Disorders that don't have an FDA approved hormone drug because testosterone and estradiol have been used for so long that they don't need testing. If there was a significant problem with them their history of use of over 5-7 decades has proven the efficacy and safety of the female hormones for treatment and hormone replacement. For Psychiatric Disorders: Some patients need compounded ketamine products for conditions like severe depression, despite lacking FDA approval for these uses and potential risks, yet it has been used for this purpose for decades and was used for childbirth for almost a century, until epidurals and saddle blocks took their place. Testosterone for women still is not recognized as a female hormone even though women produce over twice as much Testosterone as Estradiol when they are in their fertile years.   Replacement of T with bioidentical T pellets offers a treatment for dozens of symptoms women face after age 40, and it prevents the diseases of aging: osteoporosis, heart disease, sarcopenia, frailty, diabetes and more that have not been addressed by mainstream medicine and the FDA. Over a decade ago, the FDA turned down the approval of testosterone patch after over 3 years of positive research studies, the FDA said they didn't approve T for women is because the side effect of T for women, facial hair, was dangerous for women.…I cry B—–S—-!  That is really men not wanting to share testosterone replacement with women. I say leave us alone and let women and their doctors determine what they need.  It is proven that only 5% of all professionals in any profession are not trustworthy, so give doctors their due and trust that we are looking for answers to our patients' problems that you don't even know about! The FDA is paid for by us…everyone in this country. I say hands off! Speed up the approval process or forget it for older drugs and BI hormones! ~

On this episode of Taste Buds with Deb, host Debra Eckerling speaks with Noah Rothbaum, author of “The Whiskey Bible: A Complete Guide to the World's Greatest Spirit,” among others.    In the book - and in the interview - Rothbaum shares everything you ever wanted to know about whiskey, and more, including the pivotal role of Jewish immigrants in bringing whiskey to America.    “In many ways, American Jews invented whiskey in this country or at least helped popularize it, around the turn of the century, the late 1800s to 1900s,” Rothbaum explains. Because of the laws of kashrut, Jews were accustomed to making their own alcohol in the old country; a skill they brought with them when they started emigrating to America and Canada.   “Fortunately the rules for making spirits are a lot simpler than the rules for making wine,” he explains. “Most whiskey by its very nature is kosher … because there's only really three ingredients: water, yeast and grain. … The fourth ingredient is the barrel, because all whiskey comes off the still clear; the color and so much of the flavor comes from the barrel.”   “The Whiskey Bible” contains more than 600 pages of knowledge, history, and stellar recipes from bartenders from around the world, including one from Sam Ross, called "penicillin."    When Rothbaum asked where the name came from, Ross said that when he was smelling the cocktail - the different kinds of notes from the whiskey and the honey ginger syrup and the citrus - it reminded him of chicken soup aka Jewish penicillin.   More than anything, Rothbaum wants to elevate people's knowledge of and confidence in drinking whiskey.    “I wanted folks to feel empowered and savvy.” Rothbaum says. When someone hears something about whiskey, whether it's from their colleague, a know-it-all friend or they see a movie where somebody's drinking it, they can pull out “The Whiskey Bible, flip to that page or section and see what's what.   Noah Rothbaum shares his journey into the world of whiskey, numerous whiskey facts and points of history, and Sam Ross' penicillin recipe, which you can find at JewishJournal.com/podcasts.    Get “The Whiskey Bible” at your favorite bookstore and follow @Noah_Rothbaum on Instagram. For more from Taste Buds, subscribe on iTunes and YouTube, and follow @TheDEBMethod on social media.

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Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI  Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.

Mes chers camarades, bien le bonjour !Parfois on découvre des trucs par hasard et ça fait grave plaisir. Et quand on parle d'Histoire, on voit que c'est pas si rare que ça ! Même en science, la chance fait parfois la différence, un peu comme Christophe Colomb qui part pour les Indes, mais tombe sur l'Amérique ! Alors c'est parti pour un petit top des découvertes médicales dues au hasard !Bonne écoute !

National Double Cheeseburger day. Entertainment from 1996. 1st 8 track tape players installed in cars, Tanks used for the 1st time in battle, Penicillin discovered. Todays birthdays - Marco Polo, Roy Acuff, William Howard Taft, Agatha Christie, Fay Wray, Oliver Stone, Tommy Lee Jones, Kelly Keagy, Wendie Jo Sperber. Ric Ocasek died.Intro - God did good - Dianna Corcoran    https://www.diannacorcoran.com/McDonald's burger rap - Sherman GanMacarena - Los Del RioSo much for pretending - Bryan WhiteBirthdays - In da club - 50 Cent     http://50cent.com/The wabash canonball - Roy AcuffSister christian - Night RangerShake it up - The CarsExit - A memory I can't drown - Anthony Price    https://anthonypricemusic.com/countryundergroundradio.com History & Factoids webpage

In this continuation of their conversation, Chris Maffeo interviews Federico Riezzo about modern cocktail classics, Villa Mamo's terroir-driven approach, and scaling cocktail culture. Federico reflects on cocktail legends like Douglas Ankrah and the era that created enduring drinks like the Pornstar Martini, Penicillin , and Breakfast Martini, while exploring why new cocktails struggle to achieve lasting status in today's social media environment.Learn about Villa Mamo, Federico's renovated 1786 Tuscan farmhouse and boutique hospitality venue, where he collaborates with local foragers to create hyper-local botanical cocktails using terroir-driven ingredients. Discover Federico's lower ABV cocktail philosophy that encourages extended social drinking experiences and better guest engagement.Chris and Federico examine the cocktail industry's workforce challenges, discussing how modern bartenders increasingly prioritize technical innovation over essential hospitality skills like guest reading and relationship building.Perfect for bar managers, hospitality professionals, cocktail enthusiasts, and anyone interested in sustainable cocktail culture, terroir-driven mixology, and the future of the bar industry.Timestamps :00:00 From Douglas Ankrah's Porn Star Martini to the other Modern Classics08:15 Cocktail Culture Gap Analysis16:30 Villa Mamo's Terroir Approach24:45 Lower ABV Philosophy and Social Drinking32:20 Industry Workforce Challenges40:04 Future of Hospitality and Scaling Culture

Letzte Woche habe ich das Glück des Zufalls beschworen: Serendipity – das Finden von etwas, das man nicht gesucht hat. Alexander Fleming entdeckte so das Penicillin, weil eine Petrischale offen stehen blieb und Schimmel seine Bakterien tötete – ein glücklicher Zufall. Das dunkle Gegenstück zur Serendipity ist die Versuchung: eine Begegnung, die uns vom Weg abbringen will. Die Versuchung zieht oder lockt, meist wider besseres Wissen, in eine andere Richtung. Oft steckt in der Versuchung der Gegensatz zwischen Verstand und Gefühlen oder Trieben. Das Glück des Zufalls können wir nur nutzen, wenn wir der Serendipity offen und neugierig begegnen. Bei der Versuchung ist es gerade umgekehrt: Wir bestehen die Versuchung nur, wenn wir stark und stur auf unserem Weg bleiben. Serendipity testet unsere Flexibilität, Versuchung unsere Selbstkontrolle. Das Problem dabei: In der digitalen Welt ist die Versuchung millionenfacher Alltag. Soziale Netze leben davon – auf Kosten unserer Aufmerksamkeit und unserer Freiheit. Was tun?Matthias Zehnder ist Autor und Medienwissenschaftler in Basel. Er ist bekannt für inspirierende Texte, Vorträge und Seminare über Medien, die Digitalisierung und KI.Website: https://www.matthiaszehnder.ch/Newsletter abonnieren: https://www.matthiaszehnder.ch/abo/Unterstützen: https://www.matthiaszehnder.ch/unterstuetzen/Biografie und Publikationen: https://www.matthiaszehnder.ch/about/

Letzte Woche habe ich unseren Gartentisch neu gestrichen. Er hatte es nötig. Als Unterlage habe ich eine alte Ausgabe der «Zeit» verwendet. Beim Streichen ist mir ein Artikel über Reichsbürger aufgefallen – bald legte ich den Pinsel aus der Hand und begann zu lesen. Das ist Serendipity: das glückliche Finden von etwas, das man nicht gesucht hat. Dem Zufall verdanken wir Penicillin, Teflon und Post-it-Zettel. Wir sollten ihn also pflegen. Doch das Gegenteil geschieht: Algorithmen und künstliche Intelligenz filtern beim Surfen, beim Einkaufen, ja sogar bei der Partnersuche das Unerwartete heraus. Wir begegnen fast nur noch dem Erwartbaren und Nützlichen. Dabei verlieren wir nicht nur den Blick über den Rand, sondern auch Inspiration, Anregung – und Glück. Im doppelten Sinn.Matthias Zehnder ist Autor und Medienwissenschaftler in Basel. Er ist bekannt für inspirierende Texte, Vorträge und Seminare über Medien, die Digitalisierung und KI.Website: https://www.matthiaszehnder.ch/Newsletter abonnieren: https://www.matthiaszehnder.ch/abo/Unterstützen: https://www.matthiaszehnder.ch/unterstuetzen/Biografie und Publikationen: https://www.matthiaszehnder.ch/about/

„Benigne“? Dieser Begriff wird der Lebensrealität wahrhaftig nicht gerecht. Dr. Leila Koscher, Leitung der hämatologischen Sprechstunde und -Ambulanz der Abteilung Onkologie, Hämatologie und Hämostaseologie am Universitätsklinikum Frankfurt /Main, weiß natürlich, dass die Onkologie-Patienten akut krank sind. Kinder mit chronischen Hämoglobinopathien kommen „leiser“ daher, doch der oft verwendete Ausdruck „benigne Hämatologie“ passt nicht für diese Patientengruppe. Eltern und Patienten müssen oft erst einmal Verständnis für Sichelzellerkrankung oder Thalassämie entwickeln. Wer begreift schon ohne Weiteres, dass der vermeintlich gesunde Säugling nach dem positiven Befund im Neugeborenen-Screening nun täglich Penicillin nehmen soll? Beziehung aufzubauen hilft bei der Akzeptanz prophylaktischer Maßnahmen, damit das akute Thoraxsyndrom mit Beatmung auf Intensiv oder die Schmerzkrise, die so schlimm ist, dass nur Morphin noch hilft, möglichst selten vorkommen. Die Expertin ermutigt Niedergelassene, postinfektiöse Thrombopenien selbst zu begleiten. Eisenmangelanämien können sie sogar besser betreuen. Keine Vision mehr: Die Stammzelltherapie hilft vielen Patienten, sofern es Spender gibt. Mit der Gentherapie steht perspektivisch ein neuer kurativer Behandlungsansatz zur Verfügung. **Patientenratgeber und Servicematerial:** Den Patientenratgeber „Madenwürmer“ können Sie jederzeit unter https://www.infectopharm.de/fuer-patienten/patienten-ratgeber/madenwuermer/ herunterladen. Die erwähnten Servicematerialien zur Madenwurmdiagnose (Teststreifen und Abreißblock) können Ärzte zudem kostenlos anfordern unter servicematerial@infectopharm.com. Fachinformation Molevac **Link zum Transkript:** https://www.infectopharm.de/consilium/podcast/podcast-paediatrie/ **Kontakte:** Feedback zum Podcast? podcast@infectopharm.com Homepage zum Podcast: www.infectopharm.de/consilium/podcast/ Für Fachkreise: www.wissenwirkt.com und App „Wissen wirkt.“ für Android und iOS Homepage InfectoPharm: www.infectopharm.de **Disclaimer:** Der _consilium_ – Pädiatrie-Podcast dient der neutralen medizinischen Information und Fortbildung für Ärzte. Für die Inhalte sind der Moderator und die Gäste verantwortlich, sie unterliegen dem wissenschaftlichen Wandel des Faches. Änderungen sind vorbehalten. **Impressum:** _consilium_ ist eine Marke von InfectoPharm Arzneimittel und Consilium GmbH Von-Humboldt-Str. 1 64646 Heppenheim Tel.: 06252 957000 Fax: 06252 958844 E-Mail: kontakt@infectopharm.com Geschäftsführer: Philipp Zöller (Vors.), Michael Gilster, Dr. Markus Rudolph, Dr. Aldo Ammendola Registergericht: Darmstadt – HRB 24623 USt.-IdNr.: DE 172949642 Verantwortlich für den Inhalt: Dr. Markus Rudolph

"Ich liebe Penicillin", sagt die Infektiologin PD Dr. Dr. Katja de With. Manche Antibiotika wie Penicillin würden in Deutschland zu wenig genutzt, andere dann wieder ohne gute Begründung eingesetzt. Die Expertin spricht in dieser Folge über Wirkmechanismen, den etwas unpassenden Ausdruck "Breitbandantibiotika" und gibt Tipps, wie Antibiotika so wirksam und toxizitätsarm wie möglich eingesetzt werden können.

Ein Zahnarztbesuch bereitet mir grundsätzlich keine Sorgen. Vielleicht deshalb, weil ich noch nie große Schwierigkeiten mit meinen Zähnen hatte. Nach meinem letzten Besuch überfielen mich allerdings doch Bedenken. Wegen einer Zahnfleischentzündung durch fortschreitende Parodontose verschrieb mir die Ärztin Penicillin. Wenige Tage nach der Einnahme wachte ich am Morgen mit Juckreiz auf. Als ich in den Spiegel schaute, erschrak ich: Mein ganzer Körper war von Kopf bis Fuß übersät mit einem dunkelroten Ausschlag.Der Hausarzt meinte spaßeshalber, ich könnte mit meinem Aussehen binnen Sekunden ein Schwimmbad voller Menschen leeren. Mittels einer Blutabnahme schloss er Masern aus. Er ist ein guter Diagnostiker und kam zu dem Befund, dass ich auf ein bestimmtes Antibiotikum allergisch reagiere. Es dauerte Wochen, bis der Ausschlag sich verflüchtigte. Penicillin-Allergien können viel schwerere Konsequenzen nach sich ziehen, bis hin zum Tod. Mein juckender Ausschlag war eine relativ harmlose Reaktion.Haben Sie gewusst, dass Gott auch allergisch ist? Jede Lieblosigkeit gegenüber ihm und Menschen, jede Lüge, jeder böse Gedanke, Betrug, Diebstahl oder Ehebruch reizt den heiligen Gott. Bei ihm gibt es zwei entgegengesetzte Reaktionen darauf: Die eine ist Liebe, die andere Zorn. Gottes Zorn hat für den Menschen weitaus schlimmere Konsequenzen als Hautausschlag: ewige Strafe, ewiger Tod; das bedeutet ewige Trennung von ihm. Gottes Liebe allerdings bewirkt, dass er auf Sünder mit großer Barmherzigkeit reagiert und vergeben will. Das Gegenmittel für Sünde ist Jesu Blut, das er am Kreuz vergossen hat. Es ist notwendig, unser ganzes Vertrauen in das vollbrachte Erlösungswerk des Sohnes Gottes zu setzen.Sebastian WeißbacherDiese und viele weitere Andachten online lesenWeitere Informationen zu »Leben ist mehr« erhalten Sie unter www.lebenistmehr.deAudioaufnahmen: Radio Segenswelle

Convenience and quality don't always go hand in hand, but Tip Top Cocktails is changing that perception, one perfectly crafted drink at a time. Founded in 2019, Tip Top is an Atlanta-based brand known for its spirit-forward, bar-quality offerings. Childhood friends Yoni Reisman and Neal Cohen launched the company with a simple mission: make great cocktails more accessible, no bartender required. Tip Top's lineup includes time-honored classics like the Old Fashioned, Negroni, and Margarita, as well as modern favorites such as the Paper Plane, Penicillin, and Naked & Famous. Each cocktail is precisely mixed and served in a sleek 100 mL lowball-style can. The products are available in over 25 U.S. states and Washington, D.C., and carried by national retailers such as Trader Joe's, Whole Foods, Gelson's Markets, and Total Wine & More. Amid a rapidly expanding market for RTD cocktails, Tip Top has earned high praise from The New York Times, Food & Wine, and other publications. Perhaps surprisingly, the company hasn't taken any institutional funding to date. In this episode, Yoni and Neal share how an idea sparked on the music festival circuit evolved into a fast-growing brand with national reach. Their journey is a case study in bootstrapping, brand discipline, and building loyalty through an unwavering commitment to quality and customer experience. Show notes: 0:25: Interview: Neal Cohen & Yoni Reisman, Co-Founders, Tip Top Cocktails – The co-founders discuss how Tip Top's origins stem from Yoni's time in the music festival scene, recruiting award-winning bartender Miles Macquarrie to help develop the cocktails and how they emphasized authentic, balanced flavors and supported that with retro-inspired branding and educational elements like listing ingredients. Neal and Yoni also talk about Tip Top's collaborations with renowned bartenders such as Sam Ross and Joaquín Simó and how it reinforced the brand's credibility and dedication to cocktail culture. They also explain how Tip Top has relied on grassroots marketing, standout packaging, and word-of-mouth to build its brand, with its 100 mL can seen as both stylish and practical and how the company has earned respect within the hospitality industry and among professional bartenders. They explain why they continue to personally taste each batch of cocktails and have scrapped full runs when standards weren't met and how “building a brand people would truly miss” if it left the market is their North Star. Brands in this episode: Tip Top Cocktails, Straightaway Cocktails, Post Meridiem

Alexander Fleming sah 1928 eine vergammelte Petrischale und dachte: "Das ist interessant." Andere hätten sie weggeworfen. Aus seiner Beobachtung entstand das Penicillin. In der BI-Beratung erleben wir oft ähnliche Situationen: Unternehmen stehen vor chaotischen Datenlandschaften und sehen nur Probleme. SAP-Daten, CRM-Systeme, Excel-Auswertungen - alles isoliert voneinander. Die typische Situation: • CFO wartet eine Woche auf Monatsberichte • Controller sammeln manuell Daten aus verschiedenen Systemen • IT bekommt täglich neue Sonderwünsche Der Unterschied liegt im Expertenblick: Wo andere Resignation sehen, erkennen erfahrene BI-Berater das Potenzial für integrierte Lösungen. Es geht nicht um neue Tools, sondern um die richtige Architektur. Systematische Analyse vor Tool-Auswahl. Integration statt Insellösungen. Ihre Erfahrungen? Wie gehen Sie mit fragmentierten Datenlandschaften um?

Penicillin is the go-to antibiotic for many common infections - but in the UK more than 1-in-15 adults have a penicillin allergy label on their medical record. New research suggests that many with these labels are not actually allergic. Professor Sue Pavitt explains how more accurate allergy labelling might help fight the rise of antimicrobial resistance. Both Burundi and Senegal announced last week that they had eliminated trachoma. Dr Graham Easton walks us through the long road to this milestone.A passionate debate has caused division in Maharashtra, India, over the possibility of homeopaths being allowed to practice and prescribe conventional medicine. Reporter Chhavi Sachdev explains why doctors on both sides are striking. In the UK, eight babies made with the combined genetic material of three people have been born without the hereditary mitochondrial disease. We explore the implications of this breakthrough. Sex at birth might not be as random as we once thought; a new study found that families with three children of the same sex are more likely to have another child of the same sex.Presenter: Claudia Hammond Producer: Hannah Robins Assistant Producer: Alice McKee Studio Managers: Dyfan Rose and Andrew Garrett

Don researches one of the most challenging bomb cases in FBI history, a mysterious encounter with a legendary beast and an artful scientist that accidentally uncovered a revolutionary medicine. Hosted on Acast. See acast.com/privacy for more information.

Avec Dre Marie-Frédérique Paré et Dr Samuel Sassine, résidents en pédiatrie au CHU Sainte-Justine, nous vous offrons un épisode spécial afin de: faire découvrir le goût des médicaments fréquemment prescrits, tout en résumant de façon non exhaustive le spectre d'activité des antibiotiques goûtés; discuter des enjeux entourant la haute prévalence d'une mention d'allergie à la pénicilline au dossier; soulever l'importance de prendre en compte la forme pharmaceutique des médicaments lors de leur prescription. Références:American Academy of Pediatrics. Recommended Antimicrobial Agents. Red Book: 2024-2027. (33e édition).Antimicrobial Therapy, Inc. (2025). The Sanford Guide mobile app. Disponible via l'Apple Store et PlayStore.Lebel, M. H., Roy, H., & Ovetchkine, P. (2025). AntibioPed (application mobile). Montréal, CA. Blondel-Hill, E. (2025, April). Bugs & drugs: An antimicrobial/infectious diseases reference. Disponible: https://www.bugsanddrugs.org/Khan, D. A., Banerji, A., Blumenthal, K. G., et al. (2022). Drug allergy: A 2022 practice parameter update. Journal of Allergy and Clinical Immunology, 150(6), 1333-1393.Norton, A. E., Konvinse, K., Phillips, E. J. (2018). Antibiotic allergy in pediatrics. Pediatrics, 141(5), e20172497.INESSS. (2017, June). Outil d'aide à la décision en cas d'allergie aux pénicillines. Vachon, A. (2014, January). Allergies croisées et bêtalactamines. Patterson, R. A., & Stankewicz, H. A. (2023, June 20). Penicillin allergy. Sur StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.CHU Sainte-Justine. (2025). Guide de formulations magistrales.Naître et Grandir. Médicaments: comment réussir à les administrer. (2020). Bernard, A. (réal.) Découverte: Quand le médicament a mauvais goût. (avril 2025) Montréal: Radio-Canada.Les invité(e)s et l'animatrice ne déclarent aucun conflit d'intérêt. Captation et montage: Philippe Lacroix, spécialiste en audiovisuelIdée originale, réalisation et animation: Émilie Roy-St-PierreConseillère en communication: Pascale Chatagnier (depuis mai 2025) ; Katrine Louis-Seize (janvier 2024 à mai 2025)Logo: Équipe des communications et du graphisme du CHU Sainte-JustineMusique: Samuel Ross Collègues, ami(e)s et famille, merci pour votre précieux soutien. © mgparkilo 2025 Merci pour l'écoute! Allez mettre une réaction sur vos épisodes préférés, partagez la bonne nouvelle sur Facebook/Instagram et abonnez-vous pour ne rien manquer

In this episode of Barrel Room Chronicles, host Kerry Moynahan explores two unique sides of the American spirits revolution—one driven by finance, the other by flavor.First, Kerry sits down with Ryan LaValle and Hunter Robillard, of ASM Capital Partners, a venture firm dedicated to fueling the future of American Single Malt whiskey. From Hunter's early days helping his father create a maple-infused whiskey brand to Ryan's transition from Wall Street to whiskey investment, this duo is helping bridge the gap between distilleries and capital. They discuss how whiskey becomes an asset class, what makes American Single Malt such a compelling category, and how ASM is empowering distilleries to grow through thoughtful investment and strategic support.Then, in Tavern Talk Kerry speaks with Neal Cohen, co-founder of Tip Top Proper Cocktails. From their humble beginnings inspired by the music festival circuit to landing on Delta Airlines, Tip Top is redefining what ready-to-drink (RTD) cocktails can be. Neal walks us through their whiskey-forward offerings—from their high-rye bourbon Old Fashioned to their award-winning Penicillin—and shares how they've built a brand rooted in balance, convenience, and craft.Whether you're a whiskey enthusiast, an investor, or just someone curious about the next frontier in spirits, this episode pours you a full measure of insight and inspiration.

本期节目来到上海的新进话题酒吧Penicillin。作为亚洲50 Best酒吧的姊妹店，在上海也注定备受关注。火爆的长队、精致的装修、有点先锋的酒饮，还有社交媒体中关于这家店的各种讨论。钱老板在Penicillin周五开档前潜入，和调酒师Chris简单聊了聊。 如果您对葡萄酒、烈酒、啤酒或其他酒精饮料有兴趣，不妨关注公众号，或联系「杯弓舌瘾小助手」进入团购群。如果您是供应商，也可以向我们推荐合适的产品。 可以尝试在SOLUTION逮捕钱老板，地址是上海市静安区常德路529号。 关注「杯弓舌瘾」公众号，或微信搜索bgsyxzs加入听众交流群，欢迎您参与互动。 - 对话成员 - 钱老板（小红书：@钱老板） Chris（Penicillin - 上海） - 本节目由 JustPod 出品 ©上海斛律网络科技有限公司 - - 互动方式 - 商务合作：ad@justpod.fm 微博：@杯弓舌瘾TipsyProof 微信公众号：杯弓舌瘾

Editors of CMI Comms, Josh Davis, Erin McCreary and Emily McDonald return for round 2 taking turns to summarise and discuss late-breaker trials presented at ESCMID Global 2025 in Vienna, and whether or not these trials should change your practice. Part 2 covers the ALABAMA trial exploring the safety of penicillin-allergy delabelling using the penicillin allergy assessment pathway, the SOLARIO trial investigating short (≤7 days!) versus long (≥4 weeks) antibiotic courses for orthopaedic infections, the EAGLE-1 trial assessing oral gepotidacin for gonorrhoea, a randomised clinical trial (RCT) from Thailand on oral fosfomycin as carbapenem-sparing, de-escalating therapy in complicated UTIs, and a double-blind RCT from Israel comparing neutralising plasma to placebo for West Nile fever.    This episode was peer reviewed by Dr. Emanuele Rando of Hospital Universitario Virgen Macarena, Seville, Spain and is the second of this two-part series covering selected clinical trials presented at ESCMID Global 2025.  Late-breaker trialsSandoe J, et al. Penicillin allergy assessment pathway versus usual clinical care for primary care patients with a penicillin allergy record to assess safety, de-labelling and antibiotic prescribing: The ALABAMA randomised controlled trialAngkanavisan K, et al. Oral fosfomycin after carbapenems as de-escalating therapy in complicated urinary tract infection: A randomisedcontrolled trialCanetti M, et al. Neutralising plasma versus placebo for hospitalised patients with West Nile fever: a double-blind randomised controlled trialDudareva M, et al. Short or long antibiotic regimes in orthopaedics: the SOLARIO multicentre randomised controlled trialWilson, J. Phase 3 randomised trial of oral gepotidacin for the treatment of uncomplicated gonorrhoea (EAGLE-1) ReferencesIDSA. Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections; 19 Feb - 19 March 2025.Mostashari F, et al. Epidemic West Nile encephalitis, New York, 1999. Lancet. 2001. doi: 10.1016/S0140-6736(01)05480-0Angus DC. Optimizing the Trade-off Between Learning and Doing in a Pandemic. JAMA. 2020. doi: 10.1001/jama.2020.4984Dudareva M. In: The 42nd Annual Meeting of the European Bone & Joint Infection Society. Barcelona, Spain: 26-28 Sept 2024. Li HK, et al. Oral versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA). NEJM. 2019 doi: 10.1056/NEJMoa1710926

On episode #81 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 5/8/25 – 5/21/25. Hosts: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo (NEJM) Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases) Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP) Impact of most promising Ebola therapies on survival (Virology Journal) Bacterial Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams (CID) Diet and Risk for Incident Diverticulitis in Women (Annals of Internal Medicine) The Dynamics of QuantiFERON-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents(American Journal of Respiratory and Critical Care Medicine) BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection(NEJM) The Impact of Diet on Clostridioides difficile Infection (JID) Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcusaureus Bacteremia (CMI: Clinical Microbiology and Infection) Fungal The Last of US Season 2 (YouTube) Candida auris is emerging as a prevalent urinary pathogen (PLoS Pathgoens A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis (Science) Outcome predictors of Candida prosthetic joint infections (OFID) Cave-Associated Histoplasmosis Outbreak Among Travelers Returning from Costa Rica — Georgia, Texas, and Washington, December 2024–January 2025 (CDC: MMWR) Parasitic COPEG 25th Anniversary (US Embassy in Panama) USDA suspends southern border livestock imports over New World screwworm threat(CIDRAP) Moxidectin combination therapies for lymphatic filariasis (LANCET: Infectious Diseases Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Event ObjectivesRecall and summarize the role of allergy testing and challenge in diagnosis of penicillin allergy.Describe the detrimental clinical consequences of being labeled penicillin allergic.Apply their knowledge to de-label penicillin allergy in their practice.Claim CME Credit here!

This week, Hackaday's Elliot Williams and Kristina Panos met up across the universe to bring you the latest news, mystery sound, and of course, a big bunch of hacks from the previous week. In Hackaday news, the 2025 Pet Hacks Contest rolls on. You have until June 10th to show us what you've got, so head over to Hackaday.IO and get started today! On What's That Sound, Kristina actually got it this time, although she couldn't quite muster the correct name for it, however at Hackaday we'll be calling it the "glassophone" from now on. Congratulations to [disaster_recovered] who fared better and wins a limited edition Hackaday Podcast t-shirt! After that, it's on to the hacks and such, beginning with a complete and completely-documented wireless USB autopsy. We take a look at a lovely 3D-printed downspout, some DIY penicillin, and a jellybean iMac that's hiding a modern PC. Finally, we explore a really cool 3D printing technology, and ask what happened to typing 'www.'. Check out the links below if you want to follow along, and as always, tell us what you think about this episode in the comments!  

In this first-ever collaboration between Communicable and Breakpoints, the podcast of the US Society of Infectious Diseases Pharmacists, hosts Angela Huttner (Geneva, Switzerland) and Erin McCreary (Pittsburgh, USA) join trial investigators Josh Davis (Newcastle, Australia) and Steve Tong (Melbourne, Australia) to unpack the first results coming from the SNAP adaptive platform trial, which were recently presented at ESCMID Global in Vienna. Learn whether penicillin and cefazolin are non-inferior to—and maybe even safer than—flucloxacillin for penicillin-susceptible and methicillin-susceptible Staphylococcus aureus, respectively.This episode was edited by Julie Anne Justo, transcribed by Katie Lambert and Sarah Groom, and peer-reviewed by Megan Klatt and Lacy Worden. Note on conflict of interest for SNAP Data Safety Monitoring Committee (DSMC) members:Conflicts of interest were evaluated when choosing individuals to serve on the SNAP DSMC. Aside from being compensated for their duties on the committee, DSMC members have no ongoing financial relationships that relate to the trial and are not involved in the conduct of the trial in any role other than that of a DSMC member. DSMC members have no intellectual conflict of interest or bias and reviewed SNAP data in a fully objective manner. Literature:Steven Y. C. Tong, Joshua S. Davis, Emily Eichenberger et al. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015 Jul;28(3):603-61.SNAP Adaptive trial platform/results of the PSSA & MSSA domains: https://www.snaptrial.com.au/ESCMID Global April 2025 presentation:www.online.escmid.org *https://www.escmid.org/congress-events/escmid-global/programme/scientific-programme/CloCeBa trial results (ESCMID Global April 2025 presentation): www.online.escmid.org *https://www.escmid.org/congress-events/escmid-global/programme/scientific-programme/Note on access to online video of ESCMID Global presentations:In the six months following the congress:Non-ESCMID members have access if they registered for ESCMID GlobalMembers have access only if they registered for ESCMID GlobalSix months after the congress:Non-members do not have access, whatever their ESCMID Global registration statusAll members have access, whatever their ESCMID Global registration statusCAMERA 2 trial: Steven Y. C. Tong, David C. Lye, Dafna Yahav, et al. Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA BacteremiaA Randomized Clinical Trial. JAMA. 2020;323(6):527-537. doi:10.1001/jama.2020.0103 POET trial: Kasper Iversen, Nikolaj Ihlemann, Sabine U. Gill et al. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis. N Engl J Med 2019;380:415-424POET trial follow-up: Mia M. Pries-Heje, Christoffer Wiingaard, Nikolaj Ihlemann. Five-Year Outcomes of the Partial Oral Treatment of Endocarditis (POET) Trial. N Engl J Med 2022;386:601-602

Contributor: Geoff Hogan MD Educational Pearls: Penicillin allergies are relatively uncommon despite their frequent reports 10% of the population reports a penicillin allergy but only 5% of these cases are clinically significant 90-95% of patients may tolerate a rechallenge after appropriate allergy evaluation Penicillin Allergy Decision Rule (PEN-FAST) on MD Calc Useful tool to assess patients for penicillin allergies Five years or less since reaction = 2 points (even if unknown) Anaphylaxis or angioedema OR Severe cutaneous reaction = 2 points  Treatment required for reaction (e.g. epinephrine) = 1 point (even if unknown) A score of 0 on PEN-FAST indicates a less than 1% risk of a positive penicillin allergy test A score of 1 or 2 indicates a 5% risk of a positive penicillin allergy test A low score on PEN-FAST should prompt clinicians to proceed with the best empiric antibiotic for the patient's infection References Broyles AD, Banerji A, Barmettler S, et al. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs [published correction appears in J Allergy Clin Immunol Pract. 2021 Jan;9(1):603. doi: 10.1016/j.jaip.2020.10.025.] [published correction appears in J Allergy Clin Immunol Pract. 2021 Jan;9(1):605. doi: 10.1016/j.jaip.2020.11.036.]. J Allergy Clin Immunol Pract. 2020;8(9S):S16-S116. doi:10.1016/j.jaip.2020.08.006 Piotin A, Godet J, Trubiano JA, et al. Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule [published correction appears in Ann Allergy Asthma Immunol. 2022 Jun;128(6):740. doi: 10.1016/j.anai.2022.04.005.]. Ann Allergy Asthma Immunol. 2022;128(1):27-32. doi:10.1016/j.anai.2021.07.005 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review. JAMA. 2019;321(2):188-199. doi:10.1001/jama.2018.19283 Trubiano JA, Vogrin S, Chua KYL, et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Intern Med. 2020;180(5):745-752. doi:10.1001/jamainternmed.2020.0403 Summarized & edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

This week's topics include a better way to treat A-fib, managing bleeding in cardiac surgery, penicillin for strep infections, and treating pulmonary hypertension.Program notes:0:55 Ablation for afib1:51 Pulsed field ablation PFA2:55 Training physicians3:23 Prothrombin complex versus frozen plasma4:24 Noninferiority outcome5:24 Documented bleeding issue6:25 New treatment for pulmonary hypertension7:25 Improve outcomes in advanced disease8:25 Well tolerated8:40 Penicillin lowest dose to prevent pharyngitis9:40 To avoid 8.1 ng/ml steady state10:40 Get secondary prophylaxis12:10 End

Bei vielen Menschen ist in der frühen Kindheit eine Penicillin-Allergie diagnostiziert worden. Oft haben sie damals mit Symptomen wie Hautausschlag oder Durchfall auf das Antibiotikum reagiert. Aber liegt deshalb gleich eine Allergie vor? Doc Esser und Anne sprechen über Symptome und Nebenwirkungen von Penicillin – und sie erklären, wie ihr testen könnt, ob ihr wirklich allergisch gegen das Antibiotikum seid. Von Anne Schneider ;Heinz-Wilhelm Esser.

Beneath your feet lies one of the most powerful, yet overlooked, health solutions—the earth itself. In this fascinating interview, The First Lady of Nutrition sits down with Clint Ober, the pioneer of grounding (earthing), to discuss why reconnecting with the earth may be the most important health discovery of the 21st century. Together, Ann Louise and Clint explore how grounding floods the body with free electrons, reducing inflammation, calming the nervous system, improving sleep, and supporting the immune system. One can feel the effects often in as little as 30 seconds! Clint shares insights on how modern shoes with rubber or plastic soles block our natural connection to the earth, why grounding is nature's original anti-inflammatory, and practical ways to get grounded—even indoors. They also discuss the real science behind grounding, its impact on blood health, autoimmune conditions, and even cancer and COVID responses. Learn more at https://earthinginstitute.net/ and https://www.earthing.com/. Tune in and discover how grounding could transform your health from the ground up! The post Grounding: The Next Best Thing to Penicillin – Episode 190: Clint Ober first appeared on Ann Louise Gittleman, PhD, CNS.

Today is the Dad Pod!!! The mature members started the pod with Elon and Trump (5:45), Coumo/Adams (9:31), Diana Taurasi retiring (17:55), NBA season ending injuries (21:35), more Justin Tucker allegations (35:35), new music (53:10), Paradise season finale (1:18:10), and so much more!!! Don't forget to follow us @BaselessBanter on Twitter and @Baseless_Banter on IG. Also follow our host's Paul @LifeOfFatPablo, Todd @iamt0dd and Gerard @GeeRock819 on Twitter. Subscribe, rate and review the show!! Email us: baselessbanterpodcast@gmail.com. Give us your thoughts, ideas, and questions.

What is up beautiful people! I might swerve in that corner woaaaOOOaaa!!! Hope you're having a lovely day and ready to tuck into a sweet lil episode of your two favorite white boys (emre and maxime!) talking about music and craving that sweet sweet bev thirst. On the chopping block today: a heavy metal CLASSIC paired with the drink that cured all my ailments (aint that the truth!). You're darn tootin straight - WERE BACK IN BLACK!!! So put your headphones on, grab some snacks, and savour this bite sized episode. And hey, have a drink on us. Peace, love, pancakes,Behind The Bar

Dr. Arun Sunny, infectious diseases attending for ID Associates of Tampa Bay, discusses antibiotic related drug intolerances. Dr. Sunny begins by reviewing the mechanisms behind types 1 through 4 immune-mediated hypersensitivity. Next, he differentiates DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms, TEN (Toxic Epidemial Necrolysis)/Stevens-Johnson Syndrome, and AGEP (Acute Generalized Exanthematous Pustulosis). Dr, Sunny then further characterizes Beta-lactam and Penicillin drug allergies. He then closes by describing antibiotic-related toxicities and provides several examples.

National plumb pudding day. Entertainment from 1975. 1st use of penicillin, 1st spacecraft to land on an asteroid, Lincoln penny went into circulation, largest sailfish ever caught. Todays birthdays - Abraham Lincoln, Lorne Greene, Moe Bandy, Maud Adams, Michael McDonald, Joanna Kerns, Arsenio Hall, Chynna Phillips, Josh Brolin, Christina Ricci. Tom Landry died.Intro - Pour some sugar on me - Def Leppard    http://defleppard.com/Plumb pudding - The ArchiesFire- Ohio PlayersDevil in a bottle - TG SheppardBirthdays - In da club - 50 Cent     http://50cent.com/Ringo - Lorne GreeneShes not really cheatin (shes just gettin even) - Moe BandyI keep forgettin - Michael McDonaldGrowing Pains TV themeArsinio Hall in Coming to AmericaHold on - Wilson PhillipsExit - Its not love - Dokken     http://dokken.net/

Most people have heard of the Tuskegee syphilis experiment, but have you heard of what the US government did in Guatemala?Email: downtherh@protonmail.com

Like tens of millions of people, Stephen Dubner thought he had a penicillin allergy. Like the vast majority, he didn't. This misdiagnosis costs billions of dollars and causes serious health problems, so why hasn't it been fixed? And how about all the other things we think we're allergic to? SOURCES:Kimberly Blumenthal, allergist-immunologist and researcher at Mass General Hospital and Harvard Medical School.Theresa MacPhail, associate professor of science and technology studies at Stevens Institute of Technology.Thomas Platts-Mills, professor of medicine at the University of Virginia.Elena Resnick, allergist and immunologist at Mount Sinai Hospital. RESOURCES:Allergic: Our Irritated Bodies in a Changing World, by Theresa MacPhail (2023)."Evaluation and Management of Penicillin Allergy: A Review," by Erica S. Shenoy, Eric Macy, and Theresa Rowe (JAMA, 2019)."The Allergy Epidemics: 1870–2010," by Thomas Platts-Mills (The Journal of Allergy and Clinical Immunology, 2016)."Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy," by George Du Toit, Graham Roberts, et al. (The New England Journal of Medicine, 2015). EXTRAS:Freakonomics, M.D.

Alright, you yacht rockers, it's time for another round of The Old Dog Pack Show! Dr. Rees, The Governor, and Jackson are still solvin' the world's problems while you sit on your couch wonderin' how life got so complicated. In This Very Special Episode: Antibiotics and STD Roulette We're takin' a dive into the world of Ivermectin and Penicillin. And if that doesn't already sound like a fun Saturday night, wait ‘til we throw in antibiotic-resistant syphilis, gonorrhea, and chlamydia. You know, there are pros and cons to everything.  Pam Bondi vs. Janet Reno Anyone see Trump's pick for attorney general? Let's just say she's a little easier on the eyes than ol' Janet Reno. No disrespect, Janet, but we gotta call it like we see it. The Role of the Attorney General Turns out, the AG is more than just a glorified hall monitor. We're breakin' it down so even the jury can understand... which brings us to— Juries: Idiots or Geniuses? Twelve strangers, one verdict. Are they really seein' through the BS, or are they just lookin' for the closest vending machine?  Christopher Cross: Yacht Rock Dealer Extraordinaire Turns out, smooth sailing wasn't just a song—it was a lifestyle. Acid drops, pot dealing, and vibes so chill you'll wonder how this guy ever made it to the studio. So grab a cold one, slap on some sunscreen, and get ready to laugh, learn, love, and question everything you thought you knew about yacht rock and the legal system. Hey, Bud, do us a solid, will ya? Head over to Apple Podcasts or Spotify, slap us with a 5-star rating, and maybe even toss in a quick review. Look, I'm not sayin' we've earned it yet, but c'mon—we're workin' on it! While you're at it, hit that ‘subscribe' button like it owes you money. And hey, swing by olddogpack.com and sign up for The Old Dog Pack newsletter. Is it gonna change your life? Nah. But it's free, so what're ya complaining about? Most importantly—and I mean this—tell a buddy about us. We're nothin' without you guys, and we wanna grow this thing into a whole pack of you maniacs. Help us out, huh?

We meet back up with the founder of Klaris, Chase Haider to talk about making ice. Yeah, we know, sounds easy – but there is a science here. Chase gives us the in's and out's of making clear ice (with or without a Klaris machine). Jules outs the budding bromance between Uncle Brad and Chase. Uncle Brad and Jules spin up a couple of cocktails; Brad makes the classic Penicillin and Jules puts here riffy-do on it.   Penicillin Glass: Double Rocks Glass  Garnish: Candied Ginger Directions & Ingredients In your shaker tin add 1.5oz Blended Scotch whisky  1 tsp. Peated Scotch whisky (Laphroaig)  2 tsp fresh lemon juice  0.5 oz Ginger liqueur  2 tsp Honey syrup (3:1 - acacia honey is best) Double strain over ice Add garnish: skewered piece of candied ginger   Riffy-do Glass: Coupe Garnish: Candied Ginger Directions & Ingredients In your shaker tin add Egg whilte   0.75 fresh lemon juice  0.5 oz cinnamon syrup  0.5 oz ginger syrup   0.5 oz Blended Scotch  1.5 oz bacon fat washed Cognac Dry shake Shake again with ice Double strain in chilled coupe glass   TIP: When and why we use ice   Get 10% off your Klaris Ice Machine using ARTOFDRINKING10 at checkout Go to www.craftklaris.com   Get your Zbiotics Pre-Alcohol Probiotic here: zbiotics.com/ARTOFDRINKING Be sure to enter the code ARTOFDRINKING for 15% off your first order   The Art of Drinking IG: @theartofdrinkingpodcast    Jules IG: @join_jules TikTok: @join_jules Website: joinjules.com   Brad IG: @favorite_uncle_brad   This is a Redd Rock Music Podcast IG: @reddrockmusic www.reddrockmusic.com Learn more about your ad choices. Visit megaphone.fm/adchoices

The age of antibiotics began in September 1928, with the discovery of penicillin by Alexander Fleming (1881-1955), then a professor of bacteriology at St. Mary's Hospital in London. Previously there were no effective treatments against a range of bacterial infections from pneumonia to sepsis.

Hello to you listening in Laxa, Sweden!Coming to you from Whidbey Island, Washington this is Stories From Women Who Walk with 60 Seconds for Wednesdays on Whidbey and your host, Diane Wyzga.The other night I was watching Episode 16 of Season 3 of the TV series The West Wing. Sam Seaborn is visited by his former physics professor, Dr. Dalton Millgate, who wants Sam to put in a good word for the funding of the superconducting supercollider - a controversial scientific project that would cost billions. Senator Enlow from Illinois is holding up the project for political reasons. A short exchange happens in Sam's office between Dalgate, Enlow and Seaborn about what this costly project “does":   Sen. Jack Enlow, D-IL: If we can only say what benefit this thing has. No one's been able to do that.Dr. Dalton Millgate: That's because great achievement has no road map. The X-Ray is pretty good, and so is penicillin, and neither were discovered with a practical objective in mind. I mean, when the electron was discovered in 1897, it was useless. And now we have an entire world run by electronics. Haydn and Mozart never studied the classics. They couldn't. They invented them.Sam Seaborn: Discovery.Dr. Dalton Millgate: What?Sam Seaborn: Discovery is what. That's what this is used for. It's for discovery!Practical Tip: When we lose hope or direction or get discouraged about what we're about, about what our project does or is good for, remember this: it's for discovery!  And that's the road map to great achievement.Click HERE to watch the scene on YouTubeYou're always invited: “Come for the stories - stay for the magic!” Speaking of magic, would you subscribe and spread the word with a generous 5-star review and comment - it helps us all - and join us next time!Meanwhile, stop by my Quarter Moon Story Arts website to:✓ Check out Services I Offer,✓ For a no-obligation conversation about your communication challenges, get in touch with me today✓ Stay current with me as “Wyzga on Words” on Substack and on LinkedInStories From Women Who Walk Production TeamPodcaster: Diane F Wyzga & Quarter Moon Story ArtsMusic: Mer's Waltz from Crossing the Waters by Steve Schuch & Night Heron MusicAll content and image © 2019 to Present Quarter Moon Story Arts. All rights reserved.

This episode discusses five recent articles on syphilis including the effectiveness of linezolid and azithromycin, a new penicillin allergy testing algorithm, and a successful integrated response to address a syphilis epidemic in a rural American Indian community. View episode transcript and references at www.std.uw.edu.This podcast is dedicated to an STD [sexually transmitted disease] review for health care professionals who are interested in remaining up-to-date on the diagnosis, management, and prevention of STDs. Editor and host Dr. Meena Ramchandani is an Assistant Professor of Medicine at the University of Washington (UW) and Program Director of the UW Infectious Diseases Fellowship Program. 

Check out our recap and breakdown of Season 3 Episode 23 of the Big Bang Theory! We found 5 IQ Points!00:00:00 - Intro00:12:52 - Summary Begins00:14:33 - What is Lunar Ranging? 00:40:08 - Graphic Design is Science!00:53:13 - That wasn't in Frankenstein! 01:05:11 - Penicillin, life's greatest mistake01:38:25 - Did Leonard do the math right? Find us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) Music by Alex Grohl. Find official podcast on Apple and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

Bomani Jones starts today's show by recapping the Cowboys vs Lions matchup. (0:50) He reiterates his Day 1 fandom of the Detroit Lions, while reveling in the blow out win over the Dallas Cowboys. Bomani explains that he had Super Bowl aspirations for this team right until the Aidan Hutchinson injury, which has certainly hurt the teams morale. Speaking of morale, the Cowboys look terrible following that loss and Bo discusses why they showed zero fight in that game. (9:30) From there, Bomani transitions to Nick Sirianni and the Eagles, who despite the win over the Browns, have a coach who should be fired. Bo stresses his disdain for bringing your kids up to the podium during a press conference especially when they're being used as human shields. (16:40) Then Bomani briefly talks about Lincoln Riley who has lead the USC Trojans to three straight losses. And finally, another round of If You Haven't Heard stories and your Al Bundy voicemail stories. (34:00) IYHH Contributors:  Matteo Wong, Staff Writer at The Atlantic: “AI's Penicillin and X-Ray Moment” https://bit.ly/4eI8je2  Oshan Jarow, Staff Writer at Vox: “Nitrous, one of the oldest mind-altering drugs, is back" https://bit.ly/3NKRnb7  Allie Kelly, Reporter at Business Insider: “A major curveball in retirement preparedness: divorce” https://bit.ly/3BCFzEL  . . . Subscribe to The Right Time with Bomani Jones on Spotify, Apple or wherever you get your podcasts and follow the show on Instagram, Twitter, and Tik Tok for all the best moments from the show. Download Full Podcast Here: Spotify:  https://open.spotify.com/show/6N7fDvgNz2EPDIOm49aj7M?si=FCb5EzTyTYuIy9-fWs4rQA&nd=1&utm_source=hoobe&utm_medium=social Apple:  https://podcasts.apple.com/us/podcast/the-right-time-with-bomani-jones/id982639043?utm_source=hoobe&utm_medium=social Follow The Right Time with Bomani Jones on Social Media:  http://lnk.to/therighttime Support the Show:  PrizePicks: Daily Fantasy Made Easy! Visit PrizePicks.com/BOMANI and use code BOMANI for a first deposit match up to $100! Download the Viator app now to use code VIATOR10 for 10% off your first booking in the app. Cut your wireless bill to 15 bucks a month at MintMobile.com/Bomani. Learn more about your ad choices. Visit megaphone.fm/adchoices

It's not always easy to make friends, but in this week's episode, both of our storytellers take us on heartwarming and sometimes unexpected journeys to find true friendship and meaningful connections.Part 1: Eva Chebishev gets voted “Most Organized” in first grade and struggles to fit in with her peers.Part 2: Morgan Roberts is worried about how people will see her if she enters a high school math competition.Eva Chebishev (she/her) is a microbiology PhD candidate in the lab of Dr. Ana Fernandez-Sesma at the Icahn School of Medicine at Mount Sinai (ISMMS). Her research focuses on the immune response to Dengue virus (DENV) with hopes of creating a safe, effective vaccine that is protective against all four serotypes of DENV. When she finally finishes this PhD, she aims to combine her enthusiasm for science communication and public outreach with her life-long passion for musical theatre. To this end, she recently had the incredible opportunity to perform in the limited, Off-Broadway run of “Lifeline” an original musical which tells the story of Alexander Fleming's discovery of Penicillin and the ongoing, rising global public health threat of antimicrobial resistance. She was also an attendee of ComSciCon-Flagship-2024, a science communication conference for graduate students, and has guest starred on the podcast “Mattsplaining” by Matthew Storrs. Outside of the lab, she performs in, directs, and produces “The Sinai Story Project”, a student-run showcase of original stories from the ISMMS student body. Finally, she is a diversity and disability advocate for equal opportunities in science and would like to thank The Story Collider for this opportunity and her Story Collider Workshop instructors for helping her find and craft her story.Morgan Roberts is a Mechanical Engineering major in her junior year at Boise State University. She is currently pursuing aerospace engineering and has had wonderful opportunities interning for various aerospace companies in the US and is hopeful to get more! She loves playing volleyball, reading, spending time with friends and family, and working in the machine shop on campus. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It's not always easy to make friends, but in this week's episode, both of our storytellers take us on heartwarming and sometimes unexpected journeys to find true friendship and meaningful connections. Part 1: Eva Chebishev gets voted “Most Organized” in first grade and struggles to fit in with her peers. Part 2: Morgan Roberts is worried about how people will see her if she enters a high school math competition. Eva Chebishev (she/her) is a microbiology PhD candidate in the lab of Dr. Ana Fernandez-Sesma at the Icahn School of Medicine at Mount Sinai (ISMMS). Her research focuses on the immune response to Dengue virus (DENV) with hopes of creating a safe, effective vaccine that is protective against all four serotypes of DENV. When she finally finishes this PhD, she aims to combine her enthusiasm for science communication and public outreach with her life-long passion for musical theatre. To this end, she recently had the incredible opportunity to perform in the limited, Off-Broadway run of “Lifeline” an original musical which tells the story of Alexander Fleming's discovery of Penicillin and the ongoing, rising global public health threat of antimicrobial resistance. She was also an attendee of ComSciCon-Flagship-2024, a science communication conference for graduate students, and has guest starred on the podcast “Mattsplaining” by Matthew Storrs. Outside of the lab, she performs in, directs, and produces “The Sinai Story Project”, a student-run showcase of original stories from the ISMMS student body. Finally, she is a diversity and disability advocate for equal opportunities in science and would like to thank The Story Collider for this opportunity and her Story Collider Workshop instructors for helping her find and craft her story. Morgan Roberts is a Mechanical Engineering major in her junior year at Boise State University. She is currently pursuing aerospace engineering and has had wonderful opportunities interning for various aerospace companies in the US and is hopeful to get more! She loves playing volleyball, reading, spending time with friends and family, and working in the machine shop on campus. Learn more about your ad choices. Visit megaphone.fm/adchoices

The BanterThe Guys discuss the pros and cons of “Best of” lists and how they would rank some colorful local watering holes.The ConversationThe Restaurant Guys welcome acclaimed writer Robert Simonson,  a cocktail enthusiast and expert. They devise a dream team of restaurant reviewers, bond over a love of hot dogs and discuss an exclusive gin that might be worth its price.See below for The Guys' newest mashup cocktail:The Presidential Stormy Porn Star MartiniA mash up of three cocktails★ El Presidente (Rum, Curacao)★ Dark and Stormy (Black Seal Rum, Ginger)★ Pornstar Martini (Passion Fruit, Vanilla Vodka)Ingredients1    oz  Goslings Black Seal Bermuda Rum.75 oz  Chinoa Passion Fruit Liqueur.75 oz  Pierre Ferrand Orange Curacao.5   oz  Stolichnaya Vanilla Vodka.25 oz  Poire Williams (Purkhart).5   oz Ginger Syrup (same as for Penicillin - see sub recipe below)Combine all above ingredients in a mixing glass.Stir over ice until completely chilled.  Strain into coup.Dash Regan's Orange BittersDash DeGroff Bitters (Sub Angostura Bitters if necessary)Garnish: Flag of Candied Ginger and Cherry                     The Inside TrackThe Guys have known Robert for a long time and have hosted a couple of book signings to share Robert's knowledge and expertise with others. After much research, Robert has deemed The Guys' restaurant Stage Left Steak the oldest continuously running craft cocktail bar.“Cocktails come with an attached culture and I don't think I would have spent so many years writing about cocktails if that culture wasn't so fascinating,” Robert Simonson on The Restaurant Guys Podcast 2024BioRobert Simonson writes about cocktails, spirits, bars, and bartenders for the New York Times and is the creator and author of the Substack newsletter The Mix with Robert Simonson. His books include The Old-Fashioned (2014), the first single-drink cocktail book of its kind; A Proper Drink (2016), the first (and so far only) history of the modern cocktail revival; 3-Ingredient Cocktails (2017), which was nominated for a 2018 James Beard Award; The Martini Cocktail (2019), which was nominated for a 2020 James Beard Award and IACP Award and won that year's Spirited AwardReach out to The Restaurant GuysOur Sponsors The Heldrich Hotel & Conference Centerhttps://www.theheldrich.com/ Magyar Bankhttps://www.magbank.com/ Withum Accountinghttps://www.withum.com/ Our Places Stage Left Steakhttps://www.stageleft.com/ Catherine Lombardi Restauranthttps://www.catherinelombardi.com/ Stage Left Wineshophttps://www.stageleftwineshop.com/ To hear more about food, wine and the finer things in life:https://www.instagram.com/restaurantguyspodcast/https://www.facebook.com/restaurantguys**Become a Restaurant Guys Regular and get two bonus episodes per month, bonus content and Regulars Only events.**Click Below! https://www.buzzsprout.com/2401692/subscribe

HIV specialist and former punk rock musician, Eamonn Vitt, MD, joins Paul Sax MD, FIDSA, to discuss running a small private practice in NYC and his efforts to seek lower drug costs for his patients.General registration is now open for the premier ID meeting! Register for IDWeek for the opportunity to surround yourself with the ID experts who are advancing the field. Join ID professionals who want to stay current, apply state-of-the-art science to clinical care and excel in their own careers with CME/CPE/CNE/MOC credit available. Find your why and find your way to IDWeek, Oct. 16-19! https://idweek.org/registration/

In episode 585, Mike and James invite Émélie Braschi back to the podcast to talk about the tricky issue of how to deal with a potential penicillin allergy. Believe it or not there are a couple of RCTs looking at this issue. These two trials compared oral challenge alone to skin testing followed (if negative) […]

Sam Ross, of Attaboy, Milk & Honey, Temple Bar, Good Guy's, and general cocktail creation fame joins us to discuss one of said creations: the Paper Plane. Vying for position with the Penicillin as one of Ross's most famous and beloved drinks, the Paper Plane took off by employing the Last Word template and introducing some then-little-known ingredients, including non-negotiable Amaro Nonino. Listen on (or read below) to learn Ross's Paper Plane recipe — and don't forget to leave a rating, review, and subscribe! Sam Ross's Paper Plane Recipe Ingredients - ¾ ounce fresh lemon juice - ¾ ounce Aperol - ¾ ounce Amaro Nonino - ¾ ounce bourbon (above 90 proof) Directions 1. Add all ingredients to a cocktail shake with one large cube of ice. 2. Hard shake until chilled. 3. Strain into a frosted coupe glass.

NP Pulse returns this week with guest Alexander Wrynn, whose presentation at the 2024 AANP National Conference was entitled “Don't be Rash: Mastering Penicillin Allergies.” With host Sophia Thomas, Wrynn discusses classifying and managing penicillin allergies, and walks us through what he has learned in his practice about self-reported allergies to this antibiotic.  

In 1980s Berkeley, an eccentric chemist and his wife, a self-taught therapist, experimented with MDMA. Their work would kickstart a decades-long campaign to mainstream psychedelics as a therapeutic tool — one that's coming to a head this month, with a decision due from the FDA. This episode was reported and produced by Haleema Shah, edited by Lissa Soep and Matt Collette, fact-checked by Laura Bullard, engineered by Andrea Kristinsdottir and Rob Byers, and hosted by Sean Rameswaram. It's the second in a series supported with a grant from the Ferriss–UC Berkeley Psychedelic Journalism Fellowship. Transcript at vox.com/today-explained-podcast Support Today, Explained by becoming a Vox Member today: http://www.vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices